data_7VZF
# 
_entry.id   7VZF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.359 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7VZF         pdb_00007vzf 10.2210/pdb7vzf/pdb 
WWPDB D_1300025698 ?            ?                   
EMDB  EMD-32227    ?            ?                   
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of amyloid fibril formed by full-length human SOD1' 
_pdbx_database_related.db_id          EMD-32227 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7VZF 
_pdbx_database_status.recvd_initial_deposition_date   2021-11-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Wang, L.Q.'  1  ? 
'Ma, Y.Y.'    2  ? 
'Yuan, H.Y.'  3  ? 
'Zhao, K.'    4  ? 
'Zhang, M.Y.' 5  ? 
'Wang, Q.'    6  ? 
'Huang, X.'   7  ? 
'Xu, W.C.'    8  ? 
'Chen, J.'    9  ? 
'Li, D.'      10 ? 
'Zhang, D.L.' 11 ? 
'Zou, L.Y.'   12 ? 
'Yin, P.'     13 ? 
'Liu, C.'     14 ? 
'Liang, Y.'   15 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            13 
_citation.language                  ? 
_citation.page_first                3491 
_citation.page_last                 3491 
_citation.title                     
'Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion.' 
_citation.year                      2022 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-022-31240-4 
_citation.pdbx_database_id_PubMed   35715417 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wang, L.Q.'  1  0000-0002-5377-3168 
primary 'Ma, Y.'      2  0000-0002-7498-110X 
primary 'Yuan, H.Y.'  3  0000-0003-1658-5130 
primary 'Zhao, K.'    4  0000-0002-6524-8715 
primary 'Zhang, M.Y.' 5  0000-0002-4901-3860 
primary 'Wang, Q.'    6  0000-0002-7048-638X 
primary 'Huang, X.'   7  0000-0001-6321-3124 
primary 'Xu, W.C.'    8  ?                   
primary 'Dai, B.'     9  ?                   
primary 'Chen, J.'    10 ?                   
primary 'Li, D.'      11 0000-0002-1609-1539 
primary 'Zhang, D.'   12 0000-0002-5299-0718 
primary 'Wang, Z.'    13 0000-0001-5699-8330 
primary 'Zou, L.'     14 0000-0001-8066-8892 
primary 'Yin, P.'     15 0000-0001-8001-221X 
primary 'Liu, C.'     16 0000-0003-3425-6672 
primary 'Liang, Y.'   17 0000-0002-7349-8300 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7VZF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7VZF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Superoxide dismutase [Cu-Zn]' 
_entity.formula_weight             15958.757 
_entity.pdbx_number_of_molecules   3 
_entity.pdbx_ec                    1.15.1.1 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Superoxide dismutase 1,hSod1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEER
HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEER
HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   THR n 
1 4   LYS n 
1 5   ALA n 
1 6   VAL n 
1 7   CYS n 
1 8   VAL n 
1 9   LEU n 
1 10  LYS n 
1 11  GLY n 
1 12  ASP n 
1 13  GLY n 
1 14  PRO n 
1 15  VAL n 
1 16  GLN n 
1 17  GLY n 
1 18  ILE n 
1 19  ILE n 
1 20  ASN n 
1 21  PHE n 
1 22  GLU n 
1 23  GLN n 
1 24  LYS n 
1 25  GLU n 
1 26  SER n 
1 27  ASN n 
1 28  GLY n 
1 29  PRO n 
1 30  VAL n 
1 31  LYS n 
1 32  VAL n 
1 33  TRP n 
1 34  GLY n 
1 35  SER n 
1 36  ILE n 
1 37  LYS n 
1 38  GLY n 
1 39  LEU n 
1 40  THR n 
1 41  GLU n 
1 42  GLY n 
1 43  LEU n 
1 44  HIS n 
1 45  GLY n 
1 46  PHE n 
1 47  HIS n 
1 48  VAL n 
1 49  HIS n 
1 50  GLU n 
1 51  PHE n 
1 52  GLY n 
1 53  ASP n 
1 54  ASN n 
1 55  THR n 
1 56  ALA n 
1 57  GLY n 
1 58  CYS n 
1 59  THR n 
1 60  SER n 
1 61  ALA n 
1 62  GLY n 
1 63  PRO n 
1 64  HIS n 
1 65  PHE n 
1 66  ASN n 
1 67  PRO n 
1 68  LEU n 
1 69  SER n 
1 70  ARG n 
1 71  LYS n 
1 72  HIS n 
1 73  GLY n 
1 74  GLY n 
1 75  PRO n 
1 76  LYS n 
1 77  ASP n 
1 78  GLU n 
1 79  GLU n 
1 80  ARG n 
1 81  HIS n 
1 82  VAL n 
1 83  GLY n 
1 84  ASP n 
1 85  LEU n 
1 86  GLY n 
1 87  ASN n 
1 88  VAL n 
1 89  THR n 
1 90  ALA n 
1 91  ASP n 
1 92  LYS n 
1 93  ASP n 
1 94  GLY n 
1 95  VAL n 
1 96  ALA n 
1 97  ASP n 
1 98  VAL n 
1 99  SER n 
1 100 ILE n 
1 101 GLU n 
1 102 ASP n 
1 103 SER n 
1 104 VAL n 
1 105 ILE n 
1 106 SER n 
1 107 LEU n 
1 108 SER n 
1 109 GLY n 
1 110 ASP n 
1 111 HIS n 
1 112 CYS n 
1 113 ILE n 
1 114 ILE n 
1 115 GLY n 
1 116 ARG n 
1 117 THR n 
1 118 LEU n 
1 119 VAL n 
1 120 VAL n 
1 121 HIS n 
1 122 GLU n 
1 123 LYS n 
1 124 ALA n 
1 125 ASP n 
1 126 ASP n 
1 127 LEU n 
1 128 GLY n 
1 129 LYS n 
1 130 GLY n 
1 131 GLY n 
1 132 ASN n 
1 133 GLU n 
1 134 GLU n 
1 135 SER n 
1 136 THR n 
1 137 LYS n 
1 138 THR n 
1 139 GLY n 
1 140 ASN n 
1 141 ALA n 
1 142 GLY n 
1 143 SER n 
1 144 ARG n 
1 145 LEU n 
1 146 ALA n 
1 147 CYS n 
1 148 GLY n 
1 149 VAL n 
1 150 ILE n 
1 151 GLY n 
1 152 ILE n 
1 153 ALA n 
1 154 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   154 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SOD1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SODC_HUMAN 
_struct_ref.pdbx_db_accession          P00441 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEER
HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 7VZF A 1 ? 154 ? P00441 1 ? 154 ? 0 153 
2 1 7VZF B 1 ? 154 ? P00441 1 ? 154 ? 0 153 
3 1 7VZF C 1 ? 154 ? P00441 1 ? 154 ? 0 153 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7VZF 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                                   7VZF 
_struct.title                                      'Cryo-EM structure of amyloid fibril formed by full-length human SOD1' 
_struct.pdbx_structure_determination_methodology   ? 
_struct.pdbx_model_details                         ? 
_struct.pdbx_formula_weight                        ? 
_struct.pdbx_formula_weight_method                 ? 
_struct.pdbx_model_type_details                    ? 
_struct.pdbx_CASP_flag                             N 
# 
_struct_keywords.entry_id        7VZF 
_struct_keywords.text            'Amyloid fibril, PROTEIN FIBRIL' 
_struct_keywords.pdbx_keywords   'PROTEIN FIBRIL' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 3 ? 
AA3 ? 3 ? 
AA4 ? 3 ? 
AA5 ? 3 ? 
AA6 ? 3 ? 
AA7 ? 3 ? 
AA8 ? 3 ? 
AA9 ? 3 ? 
AB1 ? 3 ? 
AB2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA3 1 2 ? parallel 
AA3 2 3 ? parallel 
AA4 1 2 ? parallel 
AA4 2 3 ? parallel 
AA5 1 2 ? parallel 
AA5 2 3 ? parallel 
AA6 1 2 ? parallel 
AA6 2 3 ? parallel 
AA7 1 2 ? parallel 
AA7 2 3 ? parallel 
AA8 1 2 ? parallel 
AA8 2 3 ? parallel 
AA9 1 2 ? parallel 
AA9 2 3 ? parallel 
AB1 1 2 ? parallel 
AB1 2 3 ? parallel 
AB2 1 2 ? parallel 
AB2 2 3 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 CYS A 7   ? LEU A 9   ? CYS A 6   LEU A 8   
AA1 2 CYS B 7   ? LEU B 9   ? CYS B 6   LEU B 8   
AA1 3 CYS C 7   ? LEU C 9   ? CYS C 6   LEU C 8   
AA2 1 ILE A 18  ? ILE A 19  ? ILE A 17  ILE A 18  
AA2 2 ILE B 18  ? ILE B 19  ? ILE B 17  ILE B 18  
AA2 3 ILE C 18  ? ILE C 19  ? ILE C 17  ILE C 18  
AA3 1 LYS A 24  ? SER A 26  ? LYS A 23  SER A 25  
AA3 2 LYS B 24  ? SER B 26  ? LYS B 23  SER B 25  
AA3 3 LYS C 24  ? SER C 26  ? LYS C 23  SER C 25  
AA4 1 TRP A 33  ? GLY A 42  ? TRP A 32  GLY A 41  
AA4 2 TRP B 33  ? GLY B 42  ? TRP B 32  GLY B 41  
AA4 3 TRP C 33  ? GLY C 42  ? TRP C 32  GLY C 41  
AA5 1 ASP A 53  ? ASN A 54  ? ASP A 52  ASN A 53  
AA5 2 ASP B 53  ? ASN B 54  ? ASP B 52  ASN B 53  
AA5 3 ASP C 53  ? ASN C 54  ? ASP C 52  ASN C 53  
AA6 1 VAL A 88  ? ALA A 90  ? VAL A 87  ALA A 89  
AA6 2 VAL B 88  ? ALA B 90  ? VAL B 87  ALA B 89  
AA6 3 VAL C 88  ? ALA C 90  ? VAL C 87  ALA C 89  
AA7 1 ALA A 96  ? VAL A 98  ? ALA A 95  VAL A 97  
AA7 2 ALA B 96  ? VAL B 98  ? ALA B 95  VAL B 97  
AA7 3 ALA C 96  ? VAL C 98  ? ALA C 95  VAL C 97  
AA8 1 SER A 103 ? SER A 106 ? SER A 102 SER A 105 
AA8 2 SER B 103 ? SER B 106 ? SER B 102 SER B 105 
AA8 3 SER C 103 ? SER C 106 ? SER C 102 SER C 105 
AA9 1 ILE A 113 ? ILE A 114 ? ILE A 112 ILE A 113 
AA9 2 ILE B 113 ? ILE B 114 ? ILE B 112 ILE B 113 
AA9 3 ILE C 113 ? ILE C 114 ? ILE C 112 ILE C 113 
AB1 1 GLU A 133 ? GLU A 134 ? GLU A 132 GLU A 133 
AB1 2 GLU B 133 ? GLU B 134 ? GLU B 132 GLU B 133 
AB1 3 GLU C 133 ? GLU C 134 ? GLU C 132 GLU C 133 
AB2 1 ALA A 146 ? ALA A 153 ? ALA A 145 ALA A 152 
AB2 2 ALA B 146 ? ALA B 153 ? ALA B 145 ALA B 152 
AB2 3 ALA C 146 ? ALA C 153 ? ALA C 145 ALA C 152 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 8   ? N VAL A 7   O LEU B 9   ? O LEU B 8   
AA1 2 3 N VAL B 8   ? N VAL B 7   O LEU C 9   ? O LEU C 8   
AA2 1 2 N ILE A 19  ? N ILE A 18  O ILE B 18  ? O ILE B 17  
AA2 2 3 N ILE B 19  ? N ILE B 18  O ILE C 18  ? O ILE C 17  
AA3 1 2 N GLU A 25  ? N GLU A 24  O LYS B 24  ? O LYS B 23  
AA3 2 3 N GLU B 25  ? N GLU B 24  O LYS C 24  ? O LYS C 23  
AA4 1 2 N LEU A 39  ? N LEU A 38  O GLY B 38  ? O GLY B 37  
AA4 2 3 N LEU B 39  ? N LEU B 38  O GLY C 38  ? O GLY C 37  
AA5 1 2 N ASN A 54  ? N ASN A 53  O ASP B 53  ? O ASP B 52  
AA5 2 3 N ASN B 54  ? N ASN B 53  O ASP C 53  ? O ASP C 52  
AA6 1 2 N THR A 89  ? N THR A 88  O VAL B 88  ? O VAL B 87  
AA6 2 3 N THR B 89  ? N THR B 88  O VAL C 88  ? O VAL C 87  
AA7 1 2 N ASP A 97  ? N ASP A 96  O ASP B 97  ? O ASP B 96  
AA7 2 3 N ASP B 97  ? N ASP B 96  O ASP C 97  ? O ASP C 96  
AA8 1 2 N ILE A 105 ? N ILE A 104 O SER B 106 ? O SER B 105 
AA8 2 3 N ILE B 105 ? N ILE B 104 O SER C 106 ? O SER C 105 
AA9 1 2 N ILE A 114 ? N ILE A 113 O ILE B 113 ? O ILE B 112 
AA9 2 3 N ILE B 114 ? N ILE B 113 O ILE C 113 ? O ILE C 112 
AB1 1 2 N GLU A 134 ? N GLU A 133 O GLU B 133 ? O GLU B 132 
AB1 2 3 N GLU B 134 ? N GLU B 133 O GLU C 133 ? O GLU C 132 
AB2 1 2 N GLY A 148 ? N GLY A 147 O VAL B 149 ? O VAL B 148 
AB2 2 3 N GLY B 148 ? N GLY B 147 O VAL C 149 ? O VAL C 148 
# 
_atom_sites.entry_id                    7VZF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . LYS A 1 4   ? 191.528 130.460 173.188 1.00 76.16  ? 3   LYS A N   1 
ATOM 2    C CA  . LYS A 1 4   ? 190.369 131.131 173.769 1.00 76.16  ? 3   LYS A CA  1 
ATOM 3    C C   . LYS A 1 4   ? 190.746 132.479 174.365 1.00 76.16  ? 3   LYS A C   1 
ATOM 4    O O   . LYS A 1 4   ? 190.845 132.615 175.580 1.00 76.16  ? 3   LYS A O   1 
ATOM 5    C CB  . LYS A 1 4   ? 189.732 130.250 174.840 1.00 76.16  ? 3   LYS A CB  1 
ATOM 6    C CG  . LYS A 1 4   ? 188.382 130.733 175.304 1.00 76.16  ? 3   LYS A CG  1 
ATOM 7    C CD  . LYS A 1 4   ? 187.414 130.799 174.145 1.00 76.16  ? 3   LYS A CD  1 
ATOM 8    C CE  . LYS A 1 4   ? 187.138 129.422 173.589 1.00 76.16  ? 3   LYS A CE  1 
ATOM 9    N NZ  . LYS A 1 4   ? 186.393 128.592 174.561 1.00 76.16  ? 3   LYS A NZ  1 
ATOM 10   N N   . ALA A 1 5   ? 190.962 133.471 173.510 1.00 74.48  ? 4   ALA A N   1 
ATOM 11   C CA  . ALA A 1 5   ? 191.350 134.801 173.958 1.00 74.48  ? 4   ALA A CA  1 
ATOM 12   C C   . ALA A 1 5   ? 191.098 135.778 172.820 1.00 74.48  ? 4   ALA A C   1 
ATOM 13   O O   . ALA A 1 5   ? 190.538 135.414 171.783 1.00 74.48  ? 4   ALA A O   1 
ATOM 14   C CB  . ALA A 1 5   ? 192.809 134.823 174.419 1.00 74.48  ? 4   ALA A CB  1 
ATOM 15   N N   . VAL A 1 6   ? 191.503 137.028 173.017 1.00 71.78  ? 5   VAL A N   1 
ATOM 16   C CA  . VAL A 1 6   ? 191.371 138.063 172.006 1.00 71.78  ? 5   VAL A CA  1 
ATOM 17   C C   . VAL A 1 6   ? 192.711 138.398 171.372 1.00 71.78  ? 5   VAL A C   1 
ATOM 18   O O   . VAL A 1 6   ? 192.790 138.633 170.166 1.00 71.78  ? 5   VAL A O   1 
ATOM 19   C CB  . VAL A 1 6   ? 190.712 139.321 172.607 1.00 71.78  ? 5   VAL A CB  1 
ATOM 20   C CG1 . VAL A 1 6   ? 190.460 140.356 171.547 1.00 71.78  ? 5   VAL A CG1 1 
ATOM 21   C CG2 . VAL A 1 6   ? 189.410 138.946 173.258 1.00 71.78  ? 5   VAL A CG2 1 
ATOM 22   N N   . CYS A 1 7   ? 193.773 138.424 172.169 1.00 81.48  ? 6   CYS A N   1 
ATOM 23   C CA  . CYS A 1 7   ? 195.127 138.535 171.656 1.00 81.48  ? 6   CYS A CA  1 
ATOM 24   C C   . CYS A 1 7   ? 196.001 137.528 172.379 1.00 81.48  ? 6   CYS A C   1 
ATOM 25   O O   . CYS A 1 7   ? 195.758 137.195 173.541 1.00 81.48  ? 6   CYS A O   1 
ATOM 26   C CB  . CYS A 1 7   ? 195.708 139.934 171.851 1.00 81.48  ? 6   CYS A CB  1 
ATOM 27   S SG  . CYS A 1 7   ? 196.355 140.220 173.512 1.00 81.48  ? 6   CYS A SG  1 
ATOM 28   N N   . VAL A 1 8   ? 197.011 137.030 171.678 1.00 81.53  ? 7   VAL A N   1 
ATOM 29   C CA  . VAL A 1 8   ? 198.068 136.243 172.292 1.00 81.53  ? 7   VAL A CA  1 
ATOM 30   C C   . VAL A 1 8   ? 199.380 136.955 172.012 1.00 81.53  ? 7   VAL A C   1 
ATOM 31   O O   . VAL A 1 8   ? 199.624 137.403 170.886 1.00 81.53  ? 7   VAL A O   1 
ATOM 32   C CB  . VAL A 1 8   ? 198.082 134.790 171.782 1.00 81.53  ? 7   VAL A CB  1 
ATOM 33   C CG1 . VAL A 1 8   ? 196.694 134.193 171.879 1.00 81.53  ? 7   VAL A CG1 1 
ATOM 34   C CG2 . VAL A 1 8   ? 198.587 134.707 170.367 1.00 81.53  ? 7   VAL A CG2 1 
ATOM 35   N N   . LEU A 1 9   ? 200.197 137.109 173.045 1.00 84.87  ? 8   LEU A N   1 
ATOM 36   C CA  . LEU A 1 9   ? 201.421 137.887 172.940 1.00 84.87  ? 8   LEU A CA  1 
ATOM 37   C C   . LEU A 1 9   ? 202.614 137.008 173.270 1.00 84.87  ? 8   LEU A C   1 
ATOM 38   O O   . LEU A 1 9   ? 202.683 136.424 174.356 1.00 84.87  ? 8   LEU A O   1 
ATOM 39   C CB  . LEU A 1 9   ? 201.380 139.107 173.856 1.00 84.87  ? 8   LEU A CB  1 
ATOM 40   C CG  . LEU A 1 9   ? 202.551 140.069 173.649 1.00 84.87  ? 8   LEU A CG  1 
ATOM 41   C CD1 . LEU A 1 9   ? 202.902 140.179 172.197 1.00 84.87  ? 8   LEU A CD1 1 
ATOM 42   C CD2 . LEU A 1 9   ? 202.245 141.435 174.183 1.00 84.87  ? 8   LEU A CD2 1 
ATOM 43   N N   . LYS A 1 10  ? 203.544 136.924 172.337 1.00 87.17  ? 9   LYS A N   1 
ATOM 44   C CA  . LYS A 1 10  ? 204.787 136.199 172.525 1.00 87.17  ? 9   LYS A CA  1 
ATOM 45   C C   . LYS A 1 10  ? 206.004 137.096 172.445 1.00 87.17  ? 9   LYS A C   1 
ATOM 46   O O   . LYS A 1 10  ? 206.882 137.006 173.300 1.00 87.17  ? 9   LYS A O   1 
ATOM 47   C CB  . LYS A 1 10  ? 204.896 135.088 171.484 1.00 87.17  ? 9   LYS A CB  1 
ATOM 48   C CG  . LYS A 1 10  ? 203.648 134.238 171.397 1.00 87.17  ? 9   LYS A CG  1 
ATOM 49   C CD  . LYS A 1 10  ? 203.697 133.292 170.218 1.00 87.17  ? 9   LYS A CD  1 
ATOM 50   C CE  . LYS A 1 10  ? 202.442 132.452 170.167 1.00 87.17  ? 9   LYS A CE  1 
ATOM 51   N NZ  . LYS A 1 10  ? 202.069 131.969 171.527 1.00 87.17  ? 9   LYS A NZ  1 
ATOM 52   N N   . GLY A 1 11  ? 206.070 137.973 171.451 1.00 84.80  ? 10  GLY A N   1 
ATOM 53   C CA  . GLY A 1 11  ? 207.164 138.916 171.344 1.00 84.80  ? 10  GLY A CA  1 
ATOM 54   C C   . GLY A 1 11  ? 207.181 139.942 172.456 1.00 84.80  ? 10  GLY A C   1 
ATOM 55   O O   . GLY A 1 11  ? 206.547 139.753 173.497 1.00 84.80  ? 10  GLY A O   1 
ATOM 56   N N   . ASP A 1 12  ? 207.895 141.039 172.251 1.00 85.26  ? 11  ASP A N   1 
ATOM 57   C CA  . ASP A 1 12  ? 208.101 142.023 173.302 1.00 85.26  ? 11  ASP A CA  1 
ATOM 58   C C   . ASP A 1 12  ? 207.167 143.215 173.141 1.00 85.26  ? 11  ASP A C   1 
ATOM 59   O O   . ASP A 1 12  ? 206.675 143.511 172.050 1.00 85.26  ? 11  ASP A O   1 
ATOM 60   C CB  . ASP A 1 12  ? 209.549 142.503 173.303 1.00 85.26  ? 11  ASP A CB  1 
ATOM 61   C CG  . ASP A 1 12  ? 210.003 142.950 171.945 1.00 85.26  ? 11  ASP A CG  1 
ATOM 62   O OD1 . ASP A 1 12  ? 209.454 143.952 171.445 1.00 85.26  ? 11  ASP A OD1 1 
ATOM 63   O OD2 . ASP A 1 12  ? 210.902 142.301 171.376 1.00 85.26  ? 11  ASP A OD2 1 
ATOM 64   N N   . GLY A 1 13  ? 206.939 143.908 174.254 1.00 84.00  ? 12  GLY A N   1 
ATOM 65   C CA  . GLY A 1 13  ? 206.158 145.121 174.249 1.00 84.00  ? 12  GLY A CA  1 
ATOM 66   C C   . GLY A 1 13  ? 205.027 145.085 175.251 1.00 84.00  ? 12  GLY A C   1 
ATOM 67   O O   . GLY A 1 13  ? 204.389 144.053 175.463 1.00 84.00  ? 12  GLY A O   1 
ATOM 68   N N   . PRO A 1 14  ? 204.762 146.213 175.896 1.00 77.84  ? 13  PRO A N   1 
ATOM 69   C CA  . PRO A 1 14  ? 203.605 146.304 176.784 1.00 77.84  ? 13  PRO A CA  1 
ATOM 70   C C   . PRO A 1 14  ? 202.329 146.577 175.999 1.00 77.84  ? 13  PRO A C   1 
ATOM 71   O O   . PRO A 1 14  ? 202.350 147.024 174.853 1.00 77.84  ? 13  PRO A O   1 
ATOM 72   C CB  . PRO A 1 14  ? 203.967 147.478 177.693 1.00 77.84  ? 13  PRO A CB  1 
ATOM 73   C CG  . PRO A 1 14  ? 204.797 148.339 176.829 1.00 77.84  ? 13  PRO A CG  1 
ATOM 74   C CD  . PRO A 1 14  ? 205.575 147.435 175.928 1.00 77.84  ? 13  PRO A CD  1 
ATOM 75   N N   . VAL A 1 15  ? 201.198 146.307 176.650 1.00 72.39  ? 14  VAL A N   1 
ATOM 76   C CA  . VAL A 1 15  ? 199.921 146.269 175.949 1.00 72.39  ? 14  VAL A CA  1 
ATOM 77   C C   . VAL A 1 15  ? 199.008 147.407 176.375 1.00 72.39  ? 14  VAL A C   1 
ATOM 78   O O   . VAL A 1 15  ? 199.341 148.196 177.262 1.00 72.39  ? 14  VAL A O   1 
ATOM 79   C CB  . VAL A 1 15  ? 199.216 144.924 176.163 1.00 72.39  ? 14  VAL A CB  1 
ATOM 80   C CG1 . VAL A 1 15  ? 200.122 143.796 175.776 1.00 72.39  ? 14  VAL A CG1 1 
ATOM 81   C CG2 . VAL A 1 15  ? 198.805 144.797 177.581 1.00 72.39  ? 14  VAL A CG2 1 
ATOM 82   N N   . GLN A 1 16  ? 197.832 147.463 175.766 1.00 65.70  ? 15  GLN A N   1 
ATOM 83   C CA  . GLN A 1 16  ? 196.949 148.622 175.790 1.00 65.70  ? 15  GLN A CA  1 
ATOM 84   C C   . GLN A 1 16  ? 195.525 148.075 175.783 1.00 65.70  ? 15  GLN A C   1 
ATOM 85   O O   . GLN A 1 16  ? 195.270 146.948 176.218 1.00 65.70  ? 15  GLN A O   1 
ATOM 86   C CB  . GLN A 1 16  ? 197.280 149.558 174.616 1.00 65.70  ? 15  GLN A CB  1 
ATOM 87   C CG  . GLN A 1 16  ? 196.598 150.925 174.604 1.00 65.70  ? 15  GLN A CG  1 
ATOM 88   C CD  . GLN A 1 16  ? 197.161 151.909 175.599 1.00 65.70  ? 15  GLN A CD  1 
ATOM 89   O OE1 . GLN A 1 16  ? 197.442 151.568 176.740 1.00 65.70  ? 15  GLN A OE1 1 
ATOM 90   N NE2 . GLN A 1 16  ? 197.309 153.152 175.170 1.00 65.70  ? 15  GLN A NE2 1 
ATOM 91   N N   . GLY A 1 17  ? 194.565 148.882 175.359 1.00 60.82  ? 16  GLY A N   1 
ATOM 92   C CA  . GLY A 1 17  ? 193.191 148.432 175.298 1.00 60.82  ? 16  GLY A CA  1 
ATOM 93   C C   . GLY A 1 17  ? 192.921 147.265 174.372 1.00 60.82  ? 16  GLY A C   1 
ATOM 94   O O   . GLY A 1 17  ? 193.027 147.381 173.149 1.00 60.82  ? 16  GLY A O   1 
ATOM 95   N N   . ILE A 1 18  ? 192.582 146.126 174.966 1.00 61.16  ? 17  ILE A N   1 
ATOM 96   C CA  . ILE A 1 18  ? 191.994 144.989 174.272 1.00 61.16  ? 17  ILE A CA  1 
ATOM 97   C C   . ILE A 1 18  ? 190.707 144.651 175.004 1.00 61.16  ? 17  ILE A C   1 
ATOM 98   O O   . ILE A 1 18  ? 190.723 144.474 176.225 1.00 61.16  ? 17  ILE A O   1 
ATOM 99   C CB  . ILE A 1 18  ? 192.943 143.777 174.250 1.00 61.16  ? 17  ILE A CB  1 
ATOM 100  C CG1 . ILE A 1 18  ? 194.385 144.218 174.042 1.00 61.16  ? 17  ILE A CG1 1 
ATOM 101  C CG2 . ILE A 1 18  ? 192.553 142.813 173.156 1.00 61.16  ? 17  ILE A CG2 1 
ATOM 102  C CD1 . ILE A 1 18  ? 194.652 144.726 172.668 1.00 61.16  ? 17  ILE A CD1 1 
ATOM 103  N N   . ILE A 1 19  ? 189.589 144.579 174.280 1.00 55.40  ? 18  ILE A N   1 
ATOM 104  C CA  . ILE A 1 19  ? 188.302 144.428 174.946 1.00 55.40  ? 18  ILE A CA  1 
ATOM 105  C C   . ILE A 1 19  ? 187.496 143.308 174.304 1.00 55.40  ? 18  ILE A C   1 
ATOM 106  O O   . ILE A 1 19  ? 187.575 143.084 173.093 1.00 55.40  ? 18  ILE A O   1 
ATOM 107  C CB  . ILE A 1 19  ? 187.462 145.723 174.903 1.00 55.40  ? 18  ILE A CB  1 
ATOM 108  C CG1 . ILE A 1 19  ? 188.303 146.969 175.159 1.00 55.40  ? 18  ILE A CG1 1 
ATOM 109  C CG2 . ILE A 1 19  ? 186.413 145.676 175.986 1.00 55.40  ? 18  ILE A CG2 1 
ATOM 110  C CD1 . ILE A 1 19  ? 188.734 147.675 173.897 1.00 55.40  ? 18  ILE A CD1 1 
ATOM 111  N N   . ASN A 1 20  ? 186.687 142.621 175.124 1.00 56.86  ? 19  ASN A N   1 
ATOM 112  C CA  . ASN A 1 20  ? 185.481 141.956 174.641 1.00 56.86  ? 19  ASN A CA  1 
ATOM 113  C C   . ASN A 1 20  ? 184.295 142.320 175.525 1.00 56.86  ? 19  ASN A C   1 
ATOM 114  O O   . ASN A 1 20  ? 184.446 142.628 176.708 1.00 56.86  ? 19  ASN A O   1 
ATOM 115  C CB  . ASN A 1 20  ? 185.569 140.436 174.579 1.00 56.86  ? 19  ASN A CB  1 
ATOM 116  C CG  . ASN A 1 20  ? 185.763 139.825 175.907 1.00 56.86  ? 19  ASN A CG  1 
ATOM 117  O OD1 . ASN A 1 20  ? 186.092 140.511 176.856 1.00 56.86  ? 19  ASN A OD1 1 
ATOM 118  N ND2 . ASN A 1 20  ? 185.460 138.543 176.019 1.00 56.86  ? 19  ASN A ND2 1 
ATOM 119  N N   . PHE A 1 21  ? 183.104 142.247 174.938 1.00 57.48  ? 20  PHE A N   1 
ATOM 120  C CA  . PHE A 1 21  ? 181.883 142.741 175.554 1.00 57.48  ? 20  PHE A CA  1 
ATOM 121  C C   . PHE A 1 21  ? 180.725 141.970 174.943 1.00 57.48  ? 20  PHE A C   1 
ATOM 122  O O   . PHE A 1 21  ? 180.773 141.604 173.769 1.00 57.48  ? 20  PHE A O   1 
ATOM 123  C CB  . PHE A 1 21  ? 181.782 144.236 175.297 1.00 57.48  ? 20  PHE A CB  1 
ATOM 124  C CG  . PHE A 1 21  ? 180.870 144.985 176.214 1.00 57.48  ? 20  PHE A CG  1 
ATOM 125  C CD1 . PHE A 1 21  ? 179.554 145.187 175.882 1.00 57.48  ? 20  PHE A CD1 1 
ATOM 126  C CD2 . PHE A 1 21  ? 181.353 145.569 177.350 1.00 57.48  ? 20  PHE A CD2 1 
ATOM 127  C CE1 . PHE A 1 21  ? 178.741 145.902 176.683 1.00 57.48  ? 20  PHE A CE1 1 
ATOM 128  C CE2 . PHE A 1 21  ? 180.532 146.290 178.152 1.00 57.48  ? 20  PHE A CE2 1 
ATOM 129  C CZ  . PHE A 1 21  ? 179.225 146.449 177.821 1.00 57.48  ? 20  PHE A CZ  1 
ATOM 130  N N   . GLU A 1 22  ? 179.681 141.725 175.730 1.00 61.85  ? 21  GLU A N   1 
ATOM 131  C CA  . GLU A 1 22  ? 178.745 140.666 175.377 1.00 61.85  ? 21  GLU A CA  1 
ATOM 132  C C   . GLU A 1 22  ? 177.382 141.157 174.909 1.00 61.85  ? 21  GLU A C   1 
ATOM 133  O O   . GLU A 1 22  ? 177.059 140.999 173.729 1.00 61.85  ? 21  GLU A O   1 
ATOM 134  C CB  . GLU A 1 22  ? 178.576 139.744 176.582 1.00 61.85  ? 21  GLU A CB  1 
ATOM 135  C CG  . GLU A 1 22  ? 179.567 138.630 176.599 1.00 61.85  ? 21  GLU A CG  1 
ATOM 136  C CD  . GLU A 1 22  ? 179.315 137.649 175.491 1.00 61.85  ? 21  GLU A CD  1 
ATOM 137  O OE1 . GLU A 1 22  ? 180.088 137.654 174.518 1.00 61.85  ? 21  GLU A OE1 1 
ATOM 138  O OE2 . GLU A 1 22  ? 178.336 136.882 175.589 1.00 61.85  ? 21  GLU A OE2 1 
ATOM 139  N N   . GLN A 1 23  ? 176.600 141.807 175.766 1.00 55.87  ? 22  GLN A N   1 
ATOM 140  C CA  . GLN A 1 23  ? 175.260 142.258 175.393 1.00 55.87  ? 22  GLN A CA  1 
ATOM 141  C C   . GLN A 1 23  ? 174.456 141.135 174.734 1.00 55.87  ? 22  GLN A C   1 
ATOM 142  O O   . GLN A 1 23  ? 174.207 141.128 173.534 1.00 55.87  ? 22  GLN A O   1 
ATOM 143  C CB  . GLN A 1 23  ? 175.333 143.483 174.483 1.00 55.87  ? 22  GLN A CB  1 
ATOM 144  C CG  . GLN A 1 23  ? 175.430 144.765 175.252 1.00 55.87  ? 22  GLN A CG  1 
ATOM 145  C CD  . GLN A 1 23  ? 175.661 145.952 174.374 1.00 55.87  ? 22  GLN A CD  1 
ATOM 146  O OE1 . GLN A 1 23  ? 175.632 145.851 173.155 1.00 55.87  ? 22  GLN A OE1 1 
ATOM 147  N NE2 . GLN A 1 23  ? 175.899 147.094 174.988 1.00 55.87  ? 22  GLN A NE2 1 
ATOM 148  N N   . LYS A 1 24  ? 174.116 140.147 175.545 1.00 62.36  ? 23  LYS A N   1 
ATOM 149  C CA  . LYS A 1 24  ? 173.304 139.019 175.111 1.00 62.36  ? 23  LYS A CA  1 
ATOM 150  C C   . LYS A 1 24  ? 171.851 139.264 175.505 1.00 62.36  ? 23  LYS A C   1 
ATOM 151  O O   . LYS A 1 24  ? 171.535 139.368 176.694 1.00 62.36  ? 23  LYS A O   1 
ATOM 152  C CB  . LYS A 1 24  ? 173.838 137.730 175.729 1.00 62.36  ? 23  LYS A CB  1 
ATOM 153  C CG  . LYS A 1 24  ? 172.850 136.601 175.818 1.00 62.36  ? 23  LYS A CG  1 
ATOM 154  C CD  . LYS A 1 24  ? 173.566 135.287 176.095 1.00 62.36  ? 23  LYS A CD  1 
ATOM 155  C CE  . LYS A 1 24  ? 174.694 135.465 177.098 1.00 62.36  ? 23  LYS A CE  1 
ATOM 156  N NZ  . LYS A 1 24  ? 175.433 134.195 177.329 1.00 62.36  ? 23  LYS A NZ  1 
ATOM 157  N N   . GLU A 1 25  ? 170.973 139.358 174.507 1.00 64.35  ? 24  GLU A N   1 
ATOM 158  C CA  . GLU A 1 25  ? 169.589 139.775 174.703 1.00 64.35  ? 24  GLU A CA  1 
ATOM 159  C C   . GLU A 1 25  ? 168.638 138.838 173.979 1.00 64.35  ? 24  GLU A C   1 
ATOM 160  O O   . GLU A 1 25  ? 168.749 138.654 172.765 1.00 64.35  ? 24  GLU A O   1 
ATOM 161  C CB  . GLU A 1 25  ? 169.370 141.193 174.195 1.00 64.35  ? 24  GLU A CB  1 
ATOM 162  C CG  . GLU A 1 25  ? 167.925 141.596 174.160 1.00 64.35  ? 24  GLU A CG  1 
ATOM 163  C CD  . GLU A 1 25  ? 167.364 141.804 175.539 1.00 64.35  ? 24  GLU A CD  1 
ATOM 164  O OE1 . GLU A 1 25  ? 167.608 142.875 176.125 1.00 64.35  ? 24  GLU A OE1 1 
ATOM 165  O OE2 . GLU A 1 25  ? 166.683 140.893 176.045 1.00 64.35  ? 24  GLU A OE2 1 
ATOM 166  N N   . SER A 1 26  ? 167.682 138.281 174.717 1.00 66.49  ? 25  SER A N   1 
ATOM 167  C CA  . SER A 1 26  ? 166.728 137.320 174.181 1.00 66.49  ? 25  SER A CA  1 
ATOM 168  C C   . SER A 1 26  ? 165.320 137.762 174.531 1.00 66.49  ? 25  SER A C   1 
ATOM 169  O O   . SER A 1 26  ? 164.947 137.783 175.708 1.00 66.49  ? 25  SER A O   1 
ATOM 170  C CB  . SER A 1 26  ? 166.982 135.922 174.736 1.00 66.49  ? 25  SER A CB  1 
ATOM 171  O OG  . SER A 1 26  ? 166.777 135.907 176.133 1.00 66.49  ? 25  SER A OG  1 
ATOM 172  N N   . ASN A 1 27  ? 164.536 138.085 173.508 1.00 68.95  ? 26  ASN A N   1 
ATOM 173  C CA  . ASN A 1 27  ? 163.134 138.430 173.686 1.00 68.95  ? 26  ASN A CA  1 
ATOM 174  C C   . ASN A 1 27  ? 162.319 137.165 173.875 1.00 68.95  ? 26  ASN A C   1 
ATOM 175  O O   . ASN A 1 27  ? 162.868 136.100 174.166 1.00 68.95  ? 26  ASN A O   1 
ATOM 176  C CB  . ASN A 1 27  ? 162.611 139.211 172.488 1.00 68.95  ? 26  ASN A CB  1 
ATOM 177  C CG  . ASN A 1 27  ? 163.242 140.571 172.364 1.00 68.95  ? 26  ASN A CG  1 
ATOM 178  O OD1 . ASN A 1 27  ? 163.592 141.197 173.358 1.00 68.95  ? 26  ASN A OD1 1 
ATOM 179  N ND2 . ASN A 1 27  ? 163.385 141.042 171.135 1.00 68.95  ? 26  ASN A ND2 1 
ATOM 180  N N   . GLY A 1 28  ? 161.008 137.277 173.758 1.00 72.88  ? 27  GLY A N   1 
ATOM 181  C CA  . GLY A 1 28  ? 160.152 136.122 173.775 1.00 72.88  ? 27  GLY A CA  1 
ATOM 182  C C   . GLY A 1 28  ? 158.913 136.381 172.954 1.00 72.88  ? 27  GLY A C   1 
ATOM 183  O O   . GLY A 1 28  ? 158.954 137.034 171.907 1.00 72.88  ? 27  GLY A O   1 
ATOM 184  N N   . PRO A 1 29  ? 157.786 135.837 173.400 1.00 72.51  ? 28  PRO A N   1 
ATOM 185  C CA  . PRO A 1 29  ? 156.488 136.303 172.910 1.00 72.51  ? 28  PRO A CA  1 
ATOM 186  C C   . PRO A 1 29  ? 155.936 137.387 173.823 1.00 72.51  ? 28  PRO A C   1 
ATOM 187  O O   . PRO A 1 29  ? 156.153 137.375 175.033 1.00 72.51  ? 28  PRO A O   1 
ATOM 188  C CB  . PRO A 1 29  ? 155.642 135.028 172.957 1.00 72.51  ? 28  PRO A CB  1 
ATOM 189  C CG  . PRO A 1 29  ? 156.232 134.244 174.086 1.00 72.51  ? 28  PRO A CG  1 
ATOM 190  C CD  . PRO A 1 29  ? 157.675 134.603 174.195 1.00 72.51  ? 28  PRO A CD  1 
ATOM 191  N N   . VAL A 1 30  ? 155.234 138.360 173.245 1.00 67.92  ? 29  VAL A N   1 
ATOM 192  C CA  . VAL A 1 30  ? 154.722 139.500 174.009 1.00 67.92  ? 29  VAL A CA  1 
ATOM 193  C C   . VAL A 1 30  ? 153.191 139.504 174.086 1.00 67.92  ? 29  VAL A C   1 
ATOM 194  O O   . VAL A 1 30  ? 152.622 139.468 175.177 1.00 67.92  ? 29  VAL A O   1 
ATOM 195  C CB  . VAL A 1 30  ? 155.272 140.840 173.468 1.00 67.92  ? 29  VAL A CB  1 
ATOM 196  C CG1 . VAL A 1 30  ? 156.741 140.960 173.791 1.00 67.92  ? 29  VAL A CG1 1 
ATOM 197  C CG2 . VAL A 1 30  ? 155.073 140.973 172.005 1.00 67.92  ? 29  VAL A CG2 1 
ATOM 198  N N   . LYS A 1 31  ? 152.511 139.552 172.938 1.00 65.11  ? 30  LYS A N   1 
ATOM 199  C CA  . LYS A 1 31  ? 151.054 139.404 172.857 1.00 65.11  ? 30  LYS A CA  1 
ATOM 200  C C   . LYS A 1 31  ? 150.318 140.482 173.665 1.00 65.11  ? 30  LYS A C   1 
ATOM 201  O O   . LYS A 1 31  ? 149.746 140.232 174.725 1.00 65.11  ? 30  LYS A O   1 
ATOM 202  C CB  . LYS A 1 31  ? 150.625 137.995 173.287 1.00 65.11  ? 30  LYS A CB  1 
ATOM 203  C CG  . LYS A 1 31  ? 150.682 136.982 172.156 1.00 65.11  ? 30  LYS A CG  1 
ATOM 204  C CD  . LYS A 1 31  ? 150.246 135.608 172.610 1.00 65.11  ? 30  LYS A CD  1 
ATOM 205  C CE  . LYS A 1 31  ? 150.026 134.701 171.416 1.00 65.11  ? 30  LYS A CE  1 
ATOM 206  N NZ  . LYS A 1 31  ? 149.133 133.553 171.728 1.00 65.11  ? 30  LYS A NZ  1 
ATOM 207  N N   . VAL A 1 32  ? 150.384 141.705 173.150 1.00 56.05  ? 31  VAL A N   1 
ATOM 208  C CA  . VAL A 1 32  ? 149.596 142.822 173.661 1.00 56.05  ? 31  VAL A CA  1 
ATOM 209  C C   . VAL A 1 32  ? 148.500 143.151 172.655 1.00 56.05  ? 31  VAL A C   1 
ATOM 210  O O   . VAL A 1 32  ? 148.721 143.075 171.443 1.00 56.05  ? 31  VAL A O   1 
ATOM 211  C CB  . VAL A 1 32  ? 150.485 144.049 173.944 1.00 56.05  ? 31  VAL A CB  1 
ATOM 212  C CG1 . VAL A 1 32  ? 151.301 144.399 172.729 1.00 56.05  ? 31  VAL A CG1 1 
ATOM 213  C CG2 . VAL A 1 32  ? 149.651 145.242 174.342 1.00 56.05  ? 31  VAL A CG2 1 
ATOM 214  N N   . TRP A 1 33  ? 147.313 143.500 173.151 1.00 54.47  ? 32  TRP A N   1 
ATOM 215  C CA  . TRP A 1 33  ? 146.178 143.831 172.292 1.00 54.47  ? 32  TRP A CA  1 
ATOM 216  C C   . TRP A 1 33  ? 145.866 145.311 172.402 1.00 54.47  ? 32  TRP A C   1 
ATOM 217  O O   . TRP A 1 33  ? 145.503 145.798 173.476 1.00 54.47  ? 32  TRP A O   1 
ATOM 218  C CB  . TRP A 1 33  ? 144.944 143.016 172.646 1.00 54.47  ? 32  TRP A CB  1 
ATOM 219  C CG  . TRP A 1 33  ? 144.914 141.730 171.972 1.00 54.47  ? 32  TRP A CG  1 
ATOM 220  C CD1 . TRP A 1 33  ? 144.318 141.445 170.794 1.00 54.47  ? 32  TRP A CD1 1 
ATOM 221  C CD2 . TRP A 1 33  ? 145.515 140.526 172.427 1.00 54.47  ? 32  TRP A CD2 1 
ATOM 222  N NE1 . TRP A 1 33  ? 144.504 140.129 170.481 1.00 54.47  ? 32  TRP A NE1 1 
ATOM 223  C CE2 . TRP A 1 33  ? 145.244 139.544 171.473 1.00 54.47  ? 32  TRP A CE2 1 
ATOM 224  C CE3 . TRP A 1 33  ? 146.267 140.187 173.547 1.00 54.47  ? 32  TRP A CE3 1 
ATOM 225  C CZ2 . TRP A 1 33  ? 145.687 138.247 171.607 1.00 54.47  ? 32  TRP A CZ2 1 
ATOM 226  C CZ3 . TRP A 1 33  ? 146.704 138.906 173.677 1.00 54.47  ? 32  TRP A CZ3 1 
ATOM 227  C CH2 . TRP A 1 33  ? 146.418 137.948 172.715 1.00 54.47  ? 32  TRP A CH2 1 
ATOM 228  N N   . GLY A 1 34  ? 145.973 146.006 171.280 1.00 54.99  ? 33  GLY A N   1 
ATOM 229  C CA  . GLY A 1 34  ? 145.790 147.436 171.254 1.00 54.99  ? 33  GLY A CA  1 
ATOM 230  C C   . GLY A 1 34  ? 146.808 148.116 170.371 1.00 54.99  ? 33  GLY A C   1 
ATOM 231  O O   . GLY A 1 34  ? 146.919 147.808 169.184 1.00 54.99  ? 33  GLY A O   1 
ATOM 232  N N   . SER A 1 35  ? 147.564 149.048 170.935 1.00 54.00  ? 34  SER A N   1 
ATOM 233  C CA  . SER A 1 35  ? 148.541 149.767 170.137 1.00 54.00  ? 34  SER A CA  1 
ATOM 234  C C   . SER A 1 35  ? 149.752 150.067 170.996 1.00 54.00  ? 34  SER A C   1 
ATOM 235  O O   . SER A 1 35  ? 149.647 150.169 172.219 1.00 54.00  ? 34  SER A O   1 
ATOM 236  C CB  . SER A 1 35  ? 147.958 151.064 169.574 1.00 54.00  ? 34  SER A CB  1 
ATOM 237  O OG  . SER A 1 35  ? 147.977 152.084 170.552 1.00 54.00  ? 34  SER A OG  1 
ATOM 238  N N   . ILE A 1 36  ? 150.901 150.180 170.349 1.00 50.05  ? 35  ILE A N   1 
ATOM 239  C CA  . ILE A 1 36  ? 152.107 150.686 170.980 1.00 50.05  ? 35  ILE A CA  1 
ATOM 240  C C   . ILE A 1 36  ? 152.629 151.801 170.096 1.00 50.05  ? 35  ILE A C   1 
ATOM 241  O O   . ILE A 1 36  ? 152.612 151.680 168.868 1.00 50.05  ? 35  ILE A O   1 
ATOM 242  C CB  . ILE A 1 36  ? 153.160 149.582 171.169 1.00 50.05  ? 35  ILE A CB  1 
ATOM 243  C CG1 . ILE A 1 36  ? 152.498 148.275 171.571 1.00 50.05  ? 35  ILE A CG1 1 
ATOM 244  C CG2 . ILE A 1 36  ? 154.125 149.956 172.262 1.00 50.05  ? 35  ILE A CG2 1 
ATOM 245  C CD1 . ILE A 1 36  ? 153.440 147.119 171.600 1.00 50.05  ? 35  ILE A CD1 1 
ATOM 246  N N   . LYS A 1 37  ? 153.055 152.898 170.705 1.00 48.85  ? 36  LYS A N   1 
ATOM 247  C CA  . LYS A 1 37  ? 153.616 154.001 169.943 1.00 48.85  ? 36  LYS A CA  1 
ATOM 248  C C   . LYS A 1 37  ? 154.861 154.510 170.638 1.00 48.85  ? 36  LYS A C   1 
ATOM 249  O O   . LYS A 1 37  ? 155.004 154.391 171.855 1.00 48.85  ? 36  LYS A O   1 
ATOM 250  C CB  . LYS A 1 37  ? 152.624 155.143 169.768 1.00 48.85  ? 36  LYS A CB  1 
ATOM 251  C CG  . LYS A 1 37  ? 152.189 155.771 171.057 1.00 48.85  ? 36  LYS A CG  1 
ATOM 252  C CD  . LYS A 1 37  ? 151.059 156.737 170.827 1.00 48.85  ? 36  LYS A CD  1 
ATOM 253  C CE  . LYS A 1 37  ? 151.403 157.731 169.751 1.00 48.85  ? 36  LYS A CE  1 
ATOM 254  N NZ  . LYS A 1 37  ? 150.685 159.003 169.979 1.00 48.85  ? 36  LYS A NZ  1 
ATOM 255  N N   . GLY A 1 38  ? 155.752 155.093 169.855 1.00 51.15  ? 37  GLY A N   1 
ATOM 256  C CA  . GLY A 1 38  ? 157.023 155.494 170.401 1.00 51.15  ? 37  GLY A CA  1 
ATOM 257  C C   . GLY A 1 38  ? 157.857 154.277 170.714 1.00 51.15  ? 37  GLY A C   1 
ATOM 258  O O   . GLY A 1 38  ? 158.036 153.939 171.885 1.00 51.15  ? 37  GLY A O   1 
ATOM 259  N N   . LEU A 1 39  ? 158.334 153.589 169.677 1.00 53.78  ? 38  LEU A N   1 
ATOM 260  C CA  . LEU A 1 39  ? 159.079 152.342 169.830 1.00 53.78  ? 38  LEU A CA  1 
ATOM 261  C C   . LEU A 1 39  ? 160.346 152.386 168.987 1.00 53.78  ? 38  LEU A C   1 
ATOM 262  O O   . LEU A 1 39  ? 160.280 152.352 167.757 1.00 53.78  ? 38  LEU A O   1 
ATOM 263  C CB  . LEU A 1 39  ? 158.218 151.145 169.438 1.00 53.78  ? 38  LEU A CB  1 
ATOM 264  C CG  . LEU A 1 39  ? 158.993 149.837 169.350 1.00 53.78  ? 38  LEU A CG  1 
ATOM 265  C CD1 . LEU A 1 39  ? 159.588 149.516 170.702 1.00 53.78  ? 38  LEU A CD1 1 
ATOM 266  C CD2 . LEU A 1 39  ? 158.097 148.727 168.877 1.00 53.78  ? 38  LEU A CD2 1 
ATOM 267  N N   . THR A 1 40  ? 161.501 152.408 169.639 1.00 54.81  ? 39  THR A N   1 
ATOM 268  C CA  . THR A 1 40  ? 162.780 152.498 168.950 1.00 54.81  ? 39  THR A CA  1 
ATOM 269  C C   . THR A 1 40  ? 163.563 151.205 169.119 1.00 54.81  ? 39  THR A C   1 
ATOM 270  O O   . THR A 1 40  ? 163.608 150.643 170.214 1.00 54.81  ? 39  THR A O   1 
ATOM 271  C CB  . THR A 1 40  ? 163.583 153.675 169.490 1.00 54.81  ? 39  THR A CB  1 
ATOM 272  O OG1 . THR A 1 40  ? 163.949 153.415 170.850 1.00 54.81  ? 39  THR A OG1 1 
ATOM 273  C CG2 . THR A 1 40  ? 162.730 154.929 169.447 1.00 54.81  ? 39  THR A CG2 1 
ATOM 274  N N   . GLU A 1 41  ? 164.175 150.730 168.032 1.00 58.82  ? 40  GLU A N   1 
ATOM 275  C CA  . GLU A 1 41  ? 164.973 149.501 168.065 1.00 58.82  ? 40  GLU A CA  1 
ATOM 276  C C   . GLU A 1 41  ? 166.275 149.736 167.308 1.00 58.82  ? 40  GLU A C   1 
ATOM 277  O O   . GLU A 1 41  ? 166.313 149.647 166.081 1.00 58.82  ? 40  GLU A O   1 
ATOM 278  C CB  . GLU A 1 41  ? 164.215 148.320 167.477 1.00 58.82  ? 40  GLU A CB  1 
ATOM 279  C CG  . GLU A 1 41  ? 163.270 147.640 168.446 1.00 58.82  ? 40  GLU A CG  1 
ATOM 280  C CD  . GLU A 1 41  ? 163.978 146.723 169.410 1.00 58.82  ? 40  GLU A CD  1 
ATOM 281  O OE1 . GLU A 1 41  ? 165.222 146.764 169.470 1.00 58.82  ? 40  GLU A OE1 1 
ATOM 282  O OE2 . GLU A 1 41  ? 163.286 145.956 170.112 1.00 58.82  ? 40  GLU A OE2 1 
ATOM 283  N N   . GLY A 1 42  ? 167.336 150.005 168.038 1.00 59.87  ? 41  GLY A N   1 
ATOM 284  C CA  . GLY A 1 42  ? 168.629 150.262 167.431 1.00 59.87  ? 41  GLY A CA  1 
ATOM 285  C C   . GLY A 1 42  ? 169.719 149.435 168.072 1.00 59.87  ? 41  GLY A C   1 
ATOM 286  O O   . GLY A 1 42  ? 169.720 149.217 169.281 1.00 59.87  ? 41  GLY A O   1 
ATOM 287  N N   . LEU A 1 43  ? 170.645 148.973 167.243 1.00 53.84  ? 42  LEU A N   1 
ATOM 288  C CA  . LEU A 1 43  ? 171.751 148.152 167.724 1.00 53.84  ? 42  LEU A CA  1 
ATOM 289  C C   . LEU A 1 43  ? 172.973 148.497 166.871 1.00 53.84  ? 42  LEU A C   1 
ATOM 290  O O   . LEU A 1 43  ? 173.181 147.914 165.811 1.00 53.84  ? 42  LEU A O   1 
ATOM 291  C CB  . LEU A 1 43  ? 171.360 146.684 167.638 1.00 53.84  ? 42  LEU A CB  1 
ATOM 292  C CG  . LEU A 1 43  ? 172.234 145.462 167.857 1.00 53.84  ? 42  LEU A CG  1 
ATOM 293  C CD1 . LEU A 1 43  ? 172.483 145.237 169.292 1.00 53.84  ? 42  LEU A CD1 1 
ATOM 294  C CD2 . LEU A 1 43  ? 171.508 144.270 167.311 1.00 53.84  ? 42  LEU A CD2 1 
ATOM 295  N N   . HIS A 1 44  ? 173.733 149.499 167.310 1.00 54.71  ? 43  HIS A N   1 
ATOM 296  C CA  . HIS A 1 44  ? 175.023 149.801 166.690 1.00 54.71  ? 43  HIS A CA  1 
ATOM 297  C C   . HIS A 1 44  ? 175.830 150.720 167.593 1.00 54.71  ? 43  HIS A C   1 
ATOM 298  O O   . HIS A 1 44  ? 175.473 151.893 167.732 1.00 54.71  ? 43  HIS A O   1 
ATOM 299  C CB  . HIS A 1 44  ? 174.829 150.446 165.336 1.00 54.71  ? 43  HIS A CB  1 
ATOM 300  C CG  . HIS A 1 44  ? 173.806 151.538 165.304 1.00 54.71  ? 43  HIS A CG  1 
ATOM 301  N ND1 . HIS A 1 44  ? 173.805 152.589 166.192 1.00 54.71  ? 43  HIS A ND1 1 
ATOM 302  C CD2 . HIS A 1 44  ? 172.779 151.767 164.452 1.00 54.71  ? 43  HIS A CD2 1 
ATOM 303  C CE1 . HIS A 1 44  ? 172.800 153.399 165.913 1.00 54.71  ? 43  HIS A CE1 1 
ATOM 304  N NE2 . HIS A 1 44  ? 172.163 152.924 164.859 1.00 54.71  ? 43  HIS A NE2 1 
ATOM 305  N N   . GLY A 1 45  ? 176.901 150.214 168.206 1.00 54.09  ? 44  GLY A N   1 
ATOM 306  C CA  . GLY A 1 45  ? 177.787 151.131 168.903 1.00 54.09  ? 44  GLY A CA  1 
ATOM 307  C C   . GLY A 1 45  ? 179.268 150.898 168.700 1.00 54.09  ? 44  GLY A C   1 
ATOM 308  O O   . GLY A 1 45  ? 179.801 149.905 169.197 1.00 54.09  ? 44  GLY A O   1 
ATOM 309  N N   . PHE A 1 46  ? 179.953 151.817 168.002 1.00 50.84  ? 45  PHE A N   1 
ATOM 310  C CA  . PHE A 1 46  ? 181.412 151.752 167.877 1.00 50.84  ? 45  PHE A CA  1 
ATOM 311  C C   . PHE A 1 46  ? 181.945 153.112 167.429 1.00 50.84  ? 45  PHE A C   1 
ATOM 312  O O   . PHE A 1 46  ? 181.953 153.392 166.229 1.00 50.84  ? 45  PHE A O   1 
ATOM 313  C CB  . PHE A 1 46  ? 181.808 150.670 166.891 1.00 50.84  ? 45  PHE A CB  1 
ATOM 314  C CG  . PHE A 1 46  ? 183.247 150.289 166.962 1.00 50.84  ? 45  PHE A CG  1 
ATOM 315  C CD1 . PHE A 1 46  ? 183.677 149.350 167.862 1.00 50.84  ? 45  PHE A CD1 1 
ATOM 316  C CD2 . PHE A 1 46  ? 184.167 150.868 166.121 1.00 50.84  ? 45  PHE A CD2 1 
ATOM 317  C CE1 . PHE A 1 46  ? 184.980 149.005 167.917 1.00 50.84  ? 45  PHE A CE1 1 
ATOM 318  C CE2 . PHE A 1 46  ? 185.474 150.521 166.183 1.00 50.84  ? 45  PHE A CE2 1 
ATOM 319  C CZ  . PHE A 1 46  ? 185.879 149.592 167.080 1.00 50.84  ? 45  PHE A CZ  1 
ATOM 320  N N   . HIS A 1 47  ? 182.464 153.905 168.366 1.00 52.86  ? 46  HIS A N   1 
ATOM 321  C CA  . HIS A 1 47  ? 183.030 155.205 168.011 1.00 52.86  ? 46  HIS A CA  1 
ATOM 322  C C   . HIS A 1 47  ? 184.314 155.441 168.785 1.00 52.86  ? 46  HIS A C   1 
ATOM 323  O O   . HIS A 1 47  ? 184.314 155.436 170.017 1.00 52.86  ? 46  HIS A O   1 
ATOM 324  C CB  . HIS A 1 47  ? 182.023 156.322 168.251 1.00 52.86  ? 46  HIS A CB  1 
ATOM 325  C CG  . HIS A 1 47  ? 180.757 156.143 167.478 1.00 52.86  ? 46  HIS A CG  1 
ATOM 326  N ND1 . HIS A 1 47  ? 179.512 156.174 168.064 1.00 52.86  ? 46  HIS A ND1 1 
ATOM 327  C CD2 . HIS A 1 47  ? 180.547 155.893 166.165 1.00 52.86  ? 46  HIS A CD2 1 
ATOM 328  C CE1 . HIS A 1 47  ? 178.589 155.969 167.141 1.00 52.86  ? 46  HIS A CE1 1 
ATOM 329  N NE2 . HIS A 1 47  ? 179.191 155.796 165.980 1.00 52.86  ? 46  HIS A NE2 1 
ATOM 330  N N   . VAL A 1 48  ? 185.405 155.614 168.041 1.00 48.75  ? 47  VAL A N   1 
ATOM 331  C CA  . VAL A 1 48  ? 186.776 155.520 168.528 1.00 48.75  ? 47  VAL A CA  1 
ATOM 332  C C   . VAL A 1 48  ? 187.623 156.723 168.127 1.00 48.75  ? 47  VAL A C   1 
ATOM 333  O O   . VAL A 1 48  ? 188.650 156.550 167.471 1.00 48.75  ? 47  VAL A O   1 
ATOM 334  C CB  . VAL A 1 48  ? 187.437 154.214 168.066 1.00 48.75  ? 47  VAL A CB  1 
ATOM 335  C CG1 . VAL A 1 48  ? 188.697 153.966 168.851 1.00 48.75  ? 47  VAL A CG1 1 
ATOM 336  C CG2 . VAL A 1 48  ? 186.502 153.066 168.269 1.00 48.75  ? 47  VAL A CG2 1 
ATOM 337  N N   . HIS A 1 49  ? 187.164 157.940 168.400 1.00 50.96  ? 48  HIS A N   1 
ATOM 338  C CA  . HIS A 1 49  ? 187.762 159.165 167.859 1.00 50.96  ? 48  HIS A CA  1 
ATOM 339  C C   . HIS A 1 49  ? 189.259 159.137 167.586 1.00 50.96  ? 48  HIS A C   1 
ATOM 340  O O   . HIS A 1 49  ? 189.697 159.578 166.522 1.00 50.96  ? 48  HIS A O   1 
ATOM 341  C CB  . HIS A 1 49  ? 187.515 160.328 168.813 1.00 50.96  ? 48  HIS A CB  1 
ATOM 342  C CG  . HIS A 1 49  ? 186.089 160.752 168.886 1.00 50.96  ? 48  HIS A CG  1 
ATOM 343  N ND1 . HIS A 1 49  ? 185.555 161.372 169.994 1.00 50.96  ? 48  HIS A ND1 1 
ATOM 344  C CD2 . HIS A 1 49  ? 185.080 160.634 167.993 1.00 50.96  ? 48  HIS A CD2 1 
ATOM 345  C CE1 . HIS A 1 49  ? 184.277 161.619 169.779 1.00 50.96  ? 48  HIS A CE1 1 
ATOM 346  N NE2 . HIS A 1 49  ? 183.964 161.178 168.574 1.00 50.96  ? 48  HIS A NE2 1 
ATOM 347  N N   . GLU A 1 50  ? 190.059 158.633 168.519 1.00 52.69  ? 49  GLU A N   1 
ATOM 348  C CA  . GLU A 1 50  ? 191.503 158.660 168.331 1.00 52.69  ? 49  GLU A CA  1 
ATOM 349  C C   . GLU A 1 50  ? 192.159 157.570 169.157 1.00 52.69  ? 49  GLU A C   1 
ATOM 350  O O   . GLU A 1 50  ? 191.850 157.422 170.340 1.00 52.69  ? 49  GLU A O   1 
ATOM 351  C CB  . GLU A 1 50  ? 192.068 160.018 168.725 1.00 52.69  ? 49  GLU A CB  1 
ATOM 352  C CG  . GLU A 1 50  ? 193.433 160.306 168.182 1.00 52.69  ? 49  GLU A CG  1 
ATOM 353  C CD  . GLU A 1 50  ? 193.383 161.125 166.920 1.00 52.69  ? 49  GLU A CD  1 
ATOM 354  O OE1 . GLU A 1 50  ? 192.347 161.773 166.673 1.00 52.69  ? 49  GLU A OE1 1 
ATOM 355  O OE2 . GLU A 1 50  ? 194.392 161.143 166.189 1.00 52.69  ? 49  GLU A OE2 1 
ATOM 356  N N   . PHE A 1 51  ? 193.078 156.829 168.540 1.00 51.99  ? 50  PHE A N   1 
ATOM 357  C CA  . PHE A 1 51  ? 193.749 155.723 169.207 1.00 51.99  ? 50  PHE A CA  1 
ATOM 358  C C   . PHE A 1 51  ? 194.972 156.134 170.004 1.00 51.99  ? 50  PHE A C   1 
ATOM 359  O O   . PHE A 1 51  ? 195.444 155.345 170.822 1.00 51.99  ? 50  PHE A O   1 
ATOM 360  C CB  . PHE A 1 51  ? 194.178 154.676 168.197 1.00 51.99  ? 50  PHE A CB  1 
ATOM 361  C CG  . PHE A 1 51  ? 193.135 153.665 167.893 1.00 51.99  ? 50  PHE A CG  1 
ATOM 362  C CD1 . PHE A 1 51  ? 193.003 152.546 168.675 1.00 51.99  ? 50  PHE A CD1 1 
ATOM 363  C CD2 . PHE A 1 51  ? 192.304 153.817 166.809 1.00 51.99  ? 50  PHE A CD2 1 
ATOM 364  C CE1 . PHE A 1 51  ? 192.055 151.611 168.395 1.00 51.99  ? 50  PHE A CE1 1 
ATOM 365  C CE2 . PHE A 1 51  ? 191.356 152.877 166.524 1.00 51.99  ? 50  PHE A CE2 1 
ATOM 366  C CZ  . PHE A 1 51  ? 191.234 151.774 167.320 1.00 51.99  ? 50  PHE A CZ  1 
ATOM 367  N N   . GLY A 1 52  ? 195.511 157.319 169.781 1.00 58.29  ? 51  GLY A N   1 
ATOM 368  C CA  . GLY A 1 52  ? 196.728 157.741 170.452 1.00 58.29  ? 51  GLY A CA  1 
ATOM 369  C C   . GLY A 1 52  ? 197.943 157.554 169.556 1.00 58.29  ? 51  GLY A C   1 
ATOM 370  O O   . GLY A 1 52  ? 197.972 158.054 168.436 1.00 58.29  ? 51  GLY A O   1 
ATOM 371  N N   . ASP A 1 53  ? 198.939 156.823 170.054 1.00 62.77  ? 52  ASP A N   1 
ATOM 372  C CA  . ASP A 1 53  ? 200.136 156.568 169.262 1.00 62.77  ? 52  ASP A CA  1 
ATOM 373  C C   . ASP A 1 53  ? 200.978 155.491 169.915 1.00 62.77  ? 52  ASP A C   1 
ATOM 374  O O   . ASP A 1 53  ? 201.012 155.366 171.139 1.00 62.77  ? 52  ASP A O   1 
ATOM 375  C CB  . ASP A 1 53  ? 200.971 157.831 169.090 1.00 62.77  ? 52  ASP A CB  1 
ATOM 376  C CG  . ASP A 1 53  ? 201.085 158.608 170.357 1.00 62.77  ? 52  ASP A CG  1 
ATOM 377  O OD1 . ASP A 1 53  ? 200.379 158.247 171.314 1.00 62.77  ? 52  ASP A OD1 1 
ATOM 378  O OD2 . ASP A 1 53  ? 201.867 159.576 170.399 1.00 62.77  ? 52  ASP A OD2 1 
ATOM 379  N N   . ASN A 1 54  ? 201.674 154.736 169.076 1.00 68.08  ? 53  ASN A N   1 
ATOM 380  C CA  . ASN A 1 54  ? 202.631 153.727 169.501 1.00 68.08  ? 53  ASN A CA  1 
ATOM 381  C C   . ASN A 1 54  ? 204.038 154.224 169.214 1.00 68.08  ? 53  ASN A C   1 
ATOM 382  O O   . ASN A 1 54  ? 204.288 154.799 168.151 1.00 68.08  ? 53  ASN A O   1 
ATOM 383  C CB  . ASN A 1 54  ? 202.398 152.415 168.762 1.00 68.08  ? 53  ASN A CB  1 
ATOM 384  C CG  . ASN A 1 54  ? 201.355 151.580 169.404 1.00 68.08  ? 53  ASN A CG  1 
ATOM 385  O OD1 . ASN A 1 54  ? 201.383 151.343 170.608 1.00 68.08  ? 53  ASN A OD1 1 
ATOM 386  N ND2 . ASN A 1 54  ? 200.417 151.120 168.609 1.00 68.08  ? 53  ASN A ND2 1 
ATOM 387  N N   . THR A 1 55  ? 204.958 153.977 170.142 1.00 73.34  ? 54  THR A N   1 
ATOM 388  C CA  . THR A 1 55  ? 206.324 154.459 170.017 1.00 73.34  ? 54  THR A CA  1 
ATOM 389  C C   . THR A 1 55  ? 207.275 153.287 169.854 1.00 73.34  ? 54  THR A C   1 
ATOM 390  O O   . THR A 1 55  ? 207.243 152.347 170.652 1.00 73.34  ? 54  THR A O   1 
ATOM 391  C CB  . THR A 1 55  ? 206.747 155.265 171.229 1.00 73.34  ? 54  THR A CB  1 
ATOM 392  O OG1 . THR A 1 55  ? 206.942 154.364 172.312 1.00 73.34  ? 54  THR A OG1 1 
ATOM 393  C CG2 . THR A 1 55  ? 205.673 156.254 171.606 1.00 73.34  ? 54  THR A CG2 1 
ATOM 394  N N   . ALA A 1 56  ? 208.130 153.360 168.838 1.00 71.45  ? 55  ALA A N   1 
ATOM 395  C CA  . ALA A 1 56  ? 209.206 152.394 168.647 1.00 71.45  ? 55  ALA A CA  1 
ATOM 396  C C   . ALA A 1 56  ? 210.191 152.892 167.598 1.00 71.45  ? 55  ALA A C   1 
ATOM 397  O O   . ALA A 1 56  ? 210.847 153.914 167.785 1.00 71.45  ? 55  ALA A O   1 
ATOM 398  C CB  . ALA A 1 56  ? 208.654 151.046 168.250 1.00 71.45  ? 55  ALA A CB  1 
ATOM 399  N N   . ASN A 1 87  ? 193.054 175.476 170.133 1.00 64.71  ? 86  ASN A N   1 
ATOM 400  C CA  . ASN A 1 87  ? 192.608 176.753 169.598 1.00 64.71  ? 86  ASN A CA  1 
ATOM 401  C C   . ASN A 1 87  ? 191.149 176.687 169.179 1.00 64.71  ? 86  ASN A C   1 
ATOM 402  O O   . ASN A 1 87  ? 190.832 176.802 167.997 1.00 64.71  ? 86  ASN A O   1 
ATOM 403  C CB  . ASN A 1 87  ? 193.473 177.165 168.411 1.00 64.71  ? 86  ASN A CB  1 
ATOM 404  C CG  . ASN A 1 87  ? 193.485 178.659 168.199 1.00 64.71  ? 86  ASN A CG  1 
ATOM 405  O OD1 . ASN A 1 87  ? 193.163 179.423 169.104 1.00 64.71  ? 86  ASN A OD1 1 
ATOM 406  N ND2 . ASN A 1 87  ? 193.859 179.086 167.003 1.00 64.71  ? 86  ASN A ND2 1 
ATOM 407  N N   . VAL A 1 88  ? 190.259 176.504 170.151 1.00 65.24  ? 87  VAL A N   1 
ATOM 408  C CA  . VAL A 1 88  ? 188.831 176.354 169.894 1.00 65.24  ? 87  VAL A CA  1 
ATOM 409  C C   . VAL A 1 88  ? 188.081 177.425 170.669 1.00 65.24  ? 87  VAL A C   1 
ATOM 410  O O   . VAL A 1 88  ? 188.235 177.547 171.891 1.00 65.24  ? 87  VAL A O   1 
ATOM 411  C CB  . VAL A 1 88  ? 188.326 174.939 170.228 1.00 65.24  ? 87  VAL A CB  1 
ATOM 412  C CG1 . VAL A 1 88  ? 188.662 174.554 171.626 1.00 65.24  ? 87  VAL A CG1 1 
ATOM 413  C CG2 . VAL A 1 88  ? 186.841 174.859 170.019 1.00 65.24  ? 87  VAL A CG2 1 
ATOM 414  N N   . THR A 1 89  ? 187.278 178.204 169.949 1.00 66.33  ? 88  THR A N   1 
ATOM 415  C CA  . THR A 1 89  ? 186.678 179.415 170.497 1.00 66.33  ? 88  THR A CA  1 
ATOM 416  C C   . THR A 1 89  ? 185.312 179.644 169.867 1.00 66.33  ? 88  THR A C   1 
ATOM 417  O O   . THR A 1 89  ? 185.205 179.902 168.664 1.00 66.33  ? 88  THR A O   1 
ATOM 418  C CB  . THR A 1 89  ? 187.597 180.619 170.283 1.00 66.33  ? 88  THR A CB  1 
ATOM 419  O OG1 . THR A 1 89  ? 186.927 181.819 170.686 1.00 66.33  ? 88  THR A OG1 1 
ATOM 420  C CG2 . THR A 1 89  ? 188.078 180.722 168.844 1.00 66.33  ? 88  THR A CG2 1 
ATOM 421  N N   . ALA A 1 90  ? 184.272 179.543 170.685 1.00 67.98  ? 89  ALA A N   1 
ATOM 422  C CA  . ALA A 1 90  ? 182.920 179.900 170.293 1.00 67.98  ? 89  ALA A CA  1 
ATOM 423  C C   . ALA A 1 90  ? 182.619 181.254 170.902 1.00 67.98  ? 89  ALA A C   1 
ATOM 424  O O   . ALA A 1 90  ? 182.726 181.420 172.120 1.00 67.98  ? 89  ALA A O   1 
ATOM 425  C CB  . ALA A 1 90  ? 181.919 178.858 170.772 1.00 67.98  ? 89  ALA A CB  1 
ATOM 426  N N   . ASP A 1 91  ? 182.255 182.221 170.067 1.00 76.17  ? 90  ASP A N   1 
ATOM 427  C CA  . ASP A 1 91  ? 182.358 183.605 170.511 1.00 76.17  ? 90  ASP A CA  1 
ATOM 428  C C   . ASP A 1 91  ? 181.059 184.141 171.107 1.00 76.17  ? 90  ASP A C   1 
ATOM 429  O O   . ASP A 1 91  ? 181.007 184.476 172.292 1.00 76.17  ? 90  ASP A O   1 
ATOM 430  C CB  . ASP A 1 91  ? 182.829 184.481 169.348 1.00 76.17  ? 90  ASP A CB  1 
ATOM 431  C CG  . ASP A 1 91  ? 182.692 185.952 169.643 1.00 76.17  ? 90  ASP A CG  1 
ATOM 432  O OD1 . ASP A 1 91  ? 183.251 186.406 170.663 1.00 76.17  ? 90  ASP A OD1 1 
ATOM 433  O OD2 . ASP A 1 91  ? 182.029 186.655 168.859 1.00 76.17  ? 90  ASP A OD2 1 
ATOM 434  N N   . LYS A 1 92  ? 180.002 184.218 170.321 1.00 76.80  ? 91  LYS A N   1 
ATOM 435  C CA  . LYS A 1 92  ? 178.746 184.748 170.825 1.00 76.80  ? 91  LYS A CA  1 
ATOM 436  C C   . LYS A 1 92  ? 177.819 183.592 171.153 1.00 76.80  ? 91  LYS A C   1 
ATOM 437  O O   . LYS A 1 92  ? 177.651 182.678 170.344 1.00 76.80  ? 91  LYS A O   1 
ATOM 438  C CB  . LYS A 1 92  ? 178.101 185.692 169.818 1.00 76.80  ? 91  LYS A CB  1 
ATOM 439  C CG  . LYS A 1 92  ? 178.920 186.932 169.568 1.00 76.80  ? 91  LYS A CG  1 
ATOM 440  C CD  . LYS A 1 92  ? 179.454 187.504 170.867 1.00 76.80  ? 91  LYS A CD  1 
ATOM 441  C CE  . LYS A 1 92  ? 180.287 188.751 170.622 1.00 76.80  ? 91  LYS A CE  1 
ATOM 442  N NZ  . LYS A 1 92  ? 180.979 189.218 171.853 1.00 76.80  ? 91  LYS A NZ  1 
ATOM 443  N N   . ASP A 1 93  ? 177.305 183.586 172.376 1.00 74.97  ? 92  ASP A N   1 
ATOM 444  C CA  . ASP A 1 93  ? 176.282 182.643 172.804 1.00 74.97  ? 92  ASP A CA  1 
ATOM 445  C C   . ASP A 1 93  ? 176.769 181.200 172.761 1.00 74.97  ? 92  ASP A C   1 
ATOM 446  O O   . ASP A 1 93  ? 176.046 180.295 173.174 1.00 74.97  ? 92  ASP A O   1 
ATOM 447  C CB  . ASP A 1 93  ? 175.035 182.790 171.939 1.00 74.97  ? 92  ASP A CB  1 
ATOM 448  C CG  . ASP A 1 93  ? 174.445 184.176 172.002 1.00 74.97  ? 92  ASP A CG  1 
ATOM 449  O OD1 . ASP A 1 93  ? 174.687 184.886 172.995 1.00 74.97  ? 92  ASP A OD1 1 
ATOM 450  O OD2 . ASP A 1 93  ? 173.722 184.552 171.061 1.00 74.97  ? 92  ASP A OD2 1 
ATOM 451  N N   . GLY A 1 94  ? 177.992 180.968 172.317 1.00 67.22  ? 93  GLY A N   1 
ATOM 452  C CA  . GLY A 1 94  ? 178.382 179.641 171.903 1.00 67.22  ? 93  GLY A CA  1 
ATOM 453  C C   . GLY A 1 94  ? 178.923 178.769 173.005 1.00 67.22  ? 93  GLY A C   1 
ATOM 454  O O   . GLY A 1 94  ? 179.389 179.245 174.026 1.00 67.22  ? 93  GLY A O   1 
ATOM 455  N N   . VAL A 1 95  ? 178.894 177.466 172.755 1.00 60.96  ? 94  VAL A N   1 
ATOM 456  C CA  . VAL A 1 95  ? 179.246 176.474 173.752 1.00 60.96  ? 94  VAL A CA  1 
ATOM 457  C C   . VAL A 1 95  ? 180.608 175.892 173.405 1.00 60.96  ? 94  VAL A C   1 
ATOM 458  O O   . VAL A 1 95  ? 181.161 176.146 172.339 1.00 60.96  ? 94  VAL A O   1 
ATOM 459  C CB  . VAL A 1 95  ? 178.187 175.370 173.846 1.00 60.96  ? 94  VAL A CB  1 
ATOM 460  C CG1 . VAL A 1 95  ? 176.889 175.942 174.350 1.00 60.96  ? 94  VAL A CG1 1 
ATOM 461  C CG2 . VAL A 1 95  ? 177.986 174.753 172.508 1.00 60.96  ? 94  VAL A CG2 1 
ATOM 462  N N   . ALA A 1 96  ? 181.144 175.081 174.314 1.00 60.38  ? 95  ALA A N   1 
ATOM 463  C CA  . ALA A 1 96  ? 182.476 174.516 174.125 1.00 60.38  ? 95  ALA A CA  1 
ATOM 464  C C   . ALA A 1 96  ? 182.623 173.218 174.900 1.00 60.38  ? 95  ALA A C   1 
ATOM 465  O O   . ALA A 1 96  ? 182.471 173.207 176.123 1.00 60.38  ? 95  ALA A O   1 
ATOM 466  C CB  . ALA A 1 96  ? 183.549 175.510 174.563 1.00 60.38  ? 95  ALA A CB  1 
ATOM 467  N N   . ASP A 1 97  ? 182.938 172.135 174.192 1.00 62.83  ? 96  ASP A N   1 
ATOM 468  C CA  . ASP A 1 97  ? 183.404 170.890 174.797 1.00 62.83  ? 96  ASP A CA  1 
ATOM 469  C C   . ASP A 1 97  ? 182.390 170.312 175.788 1.00 62.83  ? 96  ASP A C   1 
ATOM 470  O O   . ASP A 1 97  ? 182.609 170.273 176.988 1.00 62.83  ? 96  ASP A O   1 
ATOM 471  C CB  . ASP A 1 97  ? 184.768 171.087 175.456 1.00 62.83  ? 96  ASP A CB  1 
ATOM 472  C CG  . ASP A 1 97  ? 185.890 170.558 174.604 1.00 62.83  ? 96  ASP A CG  1 
ATOM 473  O OD1 . ASP A 1 97  ? 185.630 170.246 173.426 1.00 62.83  ? 96  ASP A OD1 1 
ATOM 474  O OD2 . ASP A 1 97  ? 187.023 170.433 175.110 1.00 62.83  ? 96  ASP A OD2 1 
ATOM 475  N N   . VAL A 1 98  ? 181.264 169.867 175.253 1.00 55.73  ? 97  VAL A N   1 
ATOM 476  C CA  . VAL A 1 98  ? 180.294 169.126 176.045 1.00 55.73  ? 97  VAL A CA  1 
ATOM 477  C C   . VAL A 1 98  ? 179.968 167.829 175.318 1.00 55.73  ? 97  VAL A C   1 
ATOM 478  O O   . VAL A 1 98  ? 179.933 167.793 174.083 1.00 55.73  ? 97  VAL A O   1 
ATOM 479  C CB  . VAL A 1 98  ? 179.031 169.969 176.317 1.00 55.73  ? 97  VAL A CB  1 
ATOM 480  C CG1 . VAL A 1 98  ? 177.931 169.127 176.906 1.00 55.73  ? 97  VAL A CG1 1 
ATOM 481  C CG2 . VAL A 1 98  ? 179.363 171.076 177.275 1.00 55.73  ? 97  VAL A CG2 1 
ATOM 482  N N   . SER A 1 99  ? 179.754 166.759 176.083 1.00 52.80  ? 98  SER A N   1 
ATOM 483  C CA  . SER A 1 99  ? 179.525 165.441 175.505 1.00 52.80  ? 98  SER A CA  1 
ATOM 484  C C   . SER A 1 99  ? 178.644 164.628 176.437 1.00 52.80  ? 98  SER A C   1 
ATOM 485  O O   . SER A 1 99  ? 179.018 164.397 177.585 1.00 52.80  ? 98  SER A O   1 
ATOM 486  C CB  . SER A 1 99  ? 180.858 164.732 175.264 1.00 52.80  ? 98  SER A CB  1 
ATOM 487  O OG  . SER A 1 99  ? 180.706 163.588 174.446 1.00 52.80  ? 98  SER A OG  1 
ATOM 488  N N   . ILE A 1 100 ? 177.494 164.174 175.956 1.00 50.04  ? 99  ILE A N   1 
ATOM 489  C CA  . ILE A 1 100 ? 176.536 163.450 176.783 1.00 50.04  ? 99  ILE A CA  1 
ATOM 490  C C   . ILE A 1 100 ? 176.285 162.080 176.170 1.00 50.04  ? 99  ILE A C   1 
ATOM 491  O O   . ILE A 1 100 ? 176.234 161.946 174.943 1.00 50.04  ? 99  ILE A O   1 
ATOM 492  C CB  . ILE A 1 100 ? 175.209 164.228 176.926 1.00 50.04  ? 99  ILE A CB  1 
ATOM 493  C CG1 . ILE A 1 100 ? 175.429 165.567 177.616 1.00 50.04  ? 99  ILE A CG1 1 
ATOM 494  C CG2 . ILE A 1 100 ? 174.186 163.433 177.689 1.00 50.04  ? 99  ILE A CG2 1 
ATOM 495  C CD1 . ILE A 1 100 ? 175.334 166.717 176.683 1.00 50.04  ? 99  ILE A CD1 1 
ATOM 496  N N   . GLU A 1 101 ? 176.133 161.065 177.028 1.00 53.78  ? 100 GLU A N   1 
ATOM 497  C CA  . GLU A 1 101 ? 175.659 159.745 176.622 1.00 53.78  ? 100 GLU A CA  1 
ATOM 498  C C   . GLU A 1 101 ? 174.782 159.152 177.717 1.00 53.78  ? 100 GLU A C   1 
ATOM 499  O O   . GLU A 1 101 ? 174.654 159.713 178.800 1.00 53.78  ? 100 GLU A O   1 
ATOM 500  C CB  . GLU A 1 101 ? 176.817 158.803 176.294 1.00 53.78  ? 100 GLU A CB  1 
ATOM 501  C CG  . GLU A 1 101 ? 177.677 159.262 175.144 1.00 53.78  ? 100 GLU A CG  1 
ATOM 502  C CD  . GLU A 1 101 ? 178.952 158.486 175.051 1.00 53.78  ? 100 GLU A CD  1 
ATOM 503  O OE1 . GLU A 1 101 ? 178.896 157.334 174.585 1.00 53.78  ? 100 GLU A OE1 1 
ATOM 504  O OE2 . GLU A 1 101 ? 180.006 159.020 175.453 1.00 53.78  ? 100 GLU A OE2 1 
ATOM 505  N N   . ASP A 1 102 ? 174.138 158.024 177.409 1.00 54.29  ? 101 ASP A N   1 
ATOM 506  C CA  . ASP A 1 102 ? 173.353 157.246 178.376 1.00 54.29  ? 101 ASP A CA  1 
ATOM 507  C C   . ASP A 1 102 ? 172.267 158.097 179.038 1.00 54.29  ? 101 ASP A C   1 
ATOM 508  O O   . ASP A 1 102 ? 172.250 158.300 180.251 1.00 54.29  ? 101 ASP A O   1 
ATOM 509  C CB  . ASP A 1 102 ? 174.267 156.610 179.428 1.00 54.29  ? 101 ASP A CB  1 
ATOM 510  C CG  . ASP A 1 102 ? 173.716 155.310 179.981 1.00 54.29  ? 101 ASP A CG  1 
ATOM 511  O OD1 . ASP A 1 102 ? 172.486 155.187 180.126 1.00 54.29  ? 101 ASP A OD1 1 
ATOM 512  O OD2 . ASP A 1 102 ? 174.522 154.404 180.272 1.00 54.29  ? 101 ASP A OD2 1 
ATOM 513  N N   . SER A 1 103 ? 171.344 158.580 178.214 1.00 48.42  ? 102 SER A N   1 
ATOM 514  C CA  . SER A 1 103 ? 170.333 159.530 178.652 1.00 48.42  ? 102 SER A CA  1 
ATOM 515  C C   . SER A 1 103 ? 169.042 159.297 177.889 1.00 48.42  ? 102 SER A C   1 
ATOM 516  O O   . SER A 1 103 ? 169.039 159.303 176.658 1.00 48.42  ? 102 SER A O   1 
ATOM 517  C CB  . SER A 1 103 ? 170.815 160.963 178.439 1.00 48.42  ? 102 SER A CB  1 
ATOM 518  O OG  . SER A 1 103 ? 171.181 161.174 177.090 1.00 48.42  ? 102 SER A OG  1 
ATOM 519  N N   . VAL A 1 104 ? 167.951 159.113 178.620 1.00 43.23  ? 103 VAL A N   1 
ATOM 520  C CA  . VAL A 1 104 ? 166.645 158.830 178.042 1.00 43.23  ? 103 VAL A CA  1 
ATOM 521  C C   . VAL A 1 104 ? 165.624 159.802 178.613 1.00 43.23  ? 103 VAL A C   1 
ATOM 522  O O   . VAL A 1 104 ? 165.600 160.044 179.824 1.00 43.23  ? 103 VAL A O   1 
ATOM 523  C CB  . VAL A 1 104 ? 166.226 157.369 178.292 1.00 43.23  ? 103 VAL A CB  1 
ATOM 524  C CG1 . VAL A 1 104 ? 166.372 157.029 179.727 1.00 43.23  ? 103 VAL A CG1 1 
ATOM 525  C CG2 . VAL A 1 104 ? 164.792 157.162 177.893 1.00 43.23  ? 103 VAL A CG2 1 
ATOM 526  N N   . ILE A 1 105 ? 164.790 160.362 177.739 1.00 40.58  ? 104 ILE A N   1 
ATOM 527  C CA  . ILE A 1 105 ? 163.756 161.321 178.111 1.00 40.58  ? 104 ILE A CA  1 
ATOM 528  C C   . ILE A 1 105 ? 162.455 160.902 177.451 1.00 40.58  ? 104 ILE A C   1 
ATOM 529  O O   . ILE A 1 105 ? 162.362 160.874 176.221 1.00 40.58  ? 104 ILE A O   1 
ATOM 530  C CB  . ILE A 1 105 ? 164.124 162.750 177.691 1.00 40.58  ? 104 ILE A CB  1 
ATOM 531  C CG1 . ILE A 1 105 ? 165.089 163.356 178.691 1.00 40.58  ? 104 ILE A CG1 1 
ATOM 532  C CG2 . ILE A 1 105 ? 162.899 163.609 177.607 1.00 40.58  ? 104 ILE A CG2 1 
ATOM 533  C CD1 . ILE A 1 105 ? 165.486 164.733 178.332 1.00 40.58  ? 104 ILE A CD1 1 
ATOM 534  N N   . SER A 1 106 ? 161.450 160.596 178.260 1.00 43.08  ? 105 SER A N   1 
ATOM 535  C CA  . SER A 1 106 ? 160.138 160.203 177.767 1.00 43.08  ? 105 SER A CA  1 
ATOM 536  C C   . SER A 1 106 ? 159.095 161.161 178.319 1.00 43.08  ? 105 SER A C   1 
ATOM 537  O O   . SER A 1 106 ? 158.924 161.262 179.539 1.00 43.08  ? 105 SER A O   1 
ATOM 538  C CB  . SER A 1 106 ? 159.801 158.773 178.179 1.00 43.08  ? 105 SER A CB  1 
ATOM 539  O OG  . SER A 1 106 ? 159.160 158.763 179.443 1.00 43.08  ? 105 SER A OG  1 
ATOM 540  N N   . LEU A 1 107 ? 158.424 161.884 177.426 1.00 43.86  ? 106 LEU A N   1 
ATOM 541  C CA  . LEU A 1 107 ? 157.330 162.770 177.804 1.00 43.86  ? 106 LEU A CA  1 
ATOM 542  C C   . LEU A 1 107 ? 156.226 162.748 176.749 1.00 43.86  ? 106 LEU A C   1 
ATOM 543  O O   . LEU A 1 107 ? 155.737 163.789 176.312 1.00 43.86  ? 106 LEU A O   1 
ATOM 544  C CB  . LEU A 1 107 ? 157.858 164.178 178.067 1.00 43.86  ? 106 LEU A CB  1 
ATOM 545  C CG  . LEU A 1 107 ? 158.349 165.111 176.964 1.00 43.86  ? 106 LEU A CG  1 
ATOM 546  C CD1 . LEU A 1 107 ? 158.523 166.467 177.556 1.00 43.86  ? 106 LEU A CD1 1 
ATOM 547  C CD2 . LEU A 1 107 ? 159.643 164.650 176.366 1.00 43.86  ? 106 LEU A CD2 1 
ATOM 548  N N   . SER A 1 108 ? 155.822 161.556 176.310 1.00 47.51  ? 107 SER A N   1 
ATOM 549  C CA  . SER A 1 108 ? 154.959 161.463 175.134 1.00 47.51  ? 107 SER A CA  1 
ATOM 550  C C   . SER A 1 108 ? 153.644 162.212 175.341 1.00 47.51  ? 107 SER A C   1 
ATOM 551  O O   . SER A 1 108 ? 153.365 163.202 174.658 1.00 47.51  ? 107 SER A O   1 
ATOM 552  C CB  . SER A 1 108 ? 154.706 160.001 174.774 1.00 47.51  ? 107 SER A CB  1 
ATOM 553  O OG  . SER A 1 108 ? 153.991 159.914 173.557 1.00 47.51  ? 107 SER A OG  1 
ATOM 554  N N   . GLY A 1 109 ? 152.828 161.771 176.288 1.00 53.75  ? 108 GLY A N   1 
ATOM 555  C CA  . GLY A 1 109 ? 151.614 162.512 176.578 1.00 53.75  ? 108 GLY A CA  1 
ATOM 556  C C   . GLY A 1 109 ? 150.600 162.470 175.448 1.00 53.75  ? 108 GLY A C   1 
ATOM 557  O O   . GLY A 1 109 ? 150.768 161.778 174.454 1.00 53.75  ? 108 GLY A O   1 
ATOM 558  N N   . ASP A 1 110 ? 149.524 163.238 175.629 1.00 54.70  ? 109 ASP A N   1 
ATOM 559  C CA  . ASP A 1 110 ? 148.440 163.309 174.655 1.00 54.70  ? 109 ASP A CA  1 
ATOM 560  C C   . ASP A 1 110 ? 147.727 164.645 174.763 1.00 54.70  ? 109 ASP A C   1 
ATOM 561  O O   . ASP A 1 110 ? 147.618 165.214 175.852 1.00 54.70  ? 109 ASP A O   1 
ATOM 562  C CB  . ASP A 1 110 ? 147.429 162.180 174.849 1.00 54.70  ? 109 ASP A CB  1 
ATOM 563  C CG  . ASP A 1 110 ? 147.841 160.914 174.163 1.00 54.70  ? 109 ASP A CG  1 
ATOM 564  O OD1 . ASP A 1 110 ? 148.415 161.004 173.064 1.00 54.70  ? 109 ASP A OD1 1 
ATOM 565  O OD2 . ASP A 1 110 ? 147.607 159.829 174.723 1.00 54.70  ? 109 ASP A OD2 1 
ATOM 566  N N   . HIS A 1 111 ? 147.222 165.121 173.621 1.00 56.65  ? 110 HIS A N   1 
ATOM 567  C CA  . HIS A 1 111 ? 146.414 166.336 173.557 1.00 56.65  ? 110 HIS A CA  1 
ATOM 568  C C   . HIS A 1 111 ? 147.169 167.514 174.172 1.00 56.65  ? 110 HIS A C   1 
ATOM 569  O O   . HIS A 1 111 ? 146.828 168.025 175.238 1.00 56.65  ? 110 HIS A O   1 
ATOM 570  C CB  . HIS A 1 111 ? 145.065 166.131 174.251 1.00 56.65  ? 110 HIS A CB  1 
ATOM 571  C CG  . HIS A 1 111 ? 144.111 165.290 173.470 1.00 56.65  ? 110 HIS A CG  1 
ATOM 572  N ND1 . HIS A 1 111 ? 143.634 165.666 172.233 1.00 56.65  ? 110 HIS A ND1 1 
ATOM 573  C CD2 . HIS A 1 111 ? 143.557 164.086 173.738 1.00 56.65  ? 110 HIS A CD2 1 
ATOM 574  C CE1 . HIS A 1 111 ? 142.823 164.732 171.775 1.00 56.65  ? 110 HIS A CE1 1 
ATOM 575  N NE2 . HIS A 1 111 ? 142.758 163.763 172.669 1.00 56.65  ? 110 HIS A NE2 1 
ATOM 576  N N   . CYS A 1 112 ? 148.240 167.895 173.496 1.00 57.39  ? 111 CYS A N   1 
ATOM 577  C CA  . CYS A 1 112 ? 149.185 168.839 174.055 1.00 57.39  ? 111 CYS A CA  1 
ATOM 578  C C   . CYS A 1 112 ? 149.391 170.015 173.117 1.00 57.39  ? 111 CYS A C   1 
ATOM 579  O O   . CYS A 1 112 ? 149.235 169.898 171.902 1.00 57.39  ? 111 CYS A O   1 
ATOM 580  C CB  . CYS A 1 112 ? 150.521 168.158 174.344 1.00 57.39  ? 111 CYS A CB  1 
ATOM 581  S SG  . CYS A 1 112 ? 150.535 167.211 175.873 1.00 57.39  ? 111 CYS A SG  1 
ATOM 582  N N   . ILE A 1 113 ? 149.744 171.155 173.694 1.00 56.45  ? 112 ILE A N   1 
ATOM 583  C CA  . ILE A 1 113 ? 150.014 172.369 172.938 1.00 56.45  ? 112 ILE A CA  1 
ATOM 584  C C   . ILE A 1 113 ? 151.445 172.781 173.222 1.00 56.45  ? 112 ILE A C   1 
ATOM 585  O O   . ILE A 1 113 ? 151.800 173.057 174.373 1.00 56.45  ? 112 ILE A O   1 
ATOM 586  C CB  . ILE A 1 113 ? 149.043 173.495 173.302 1.00 56.45  ? 112 ILE A CB  1 
ATOM 587  C CG1 . ILE A 1 113 ? 147.622 172.958 173.323 1.00 56.45  ? 112 ILE A CG1 1 
ATOM 588  C CG2 . ILE A 1 113 ? 149.127 174.591 172.286 1.00 56.45  ? 112 ILE A CG2 1 
ATOM 589  C CD1 . ILE A 1 113 ? 146.665 173.827 174.077 1.00 56.45  ? 112 ILE A CD1 1 
ATOM 590  N N   . ILE A 1 114 ? 152.261 172.830 172.180 1.00 56.54  ? 113 ILE A N   1 
ATOM 591  C CA  . ILE A 1 114 ? 153.681 173.111 172.309 1.00 56.54  ? 113 ILE A CA  1 
ATOM 592  C C   . ILE A 1 114 ? 153.963 174.393 171.551 1.00 56.54  ? 113 ILE A C   1 
ATOM 593  O O   . ILE A 1 114 ? 153.846 174.430 170.322 1.00 56.54  ? 113 ILE A O   1 
ATOM 594  C CB  . ILE A 1 114 ? 154.540 171.962 171.774 1.00 56.54  ? 113 ILE A CB  1 
ATOM 595  C CG1 . ILE A 1 114 ? 154.395 170.738 172.663 1.00 56.54  ? 113 ILE A CG1 1 
ATOM 596  C CG2 . ILE A 1 114 ? 155.970 172.370 171.726 1.00 56.54  ? 113 ILE A CG2 1 
ATOM 597  C CD1 . ILE A 1 114 ? 154.456 169.453 171.911 1.00 56.54  ? 113 ILE A CD1 1 
ATOM 598  N N   . GLY A 1 115 ? 154.330 175.433 172.266 1.00 61.35  ? 114 GLY A N   1 
ATOM 599  C CA  . GLY A 1 115 ? 154.647 176.692 171.631 1.00 61.35  ? 114 GLY A CA  1 
ATOM 600  C C   . GLY A 1 115 ? 154.215 177.847 172.503 1.00 61.35  ? 114 GLY A C   1 
ATOM 601  O O   . GLY A 1 115 ? 153.762 177.666 173.627 1.00 61.35  ? 114 GLY A O   1 
ATOM 602  N N   . ARG A 1 116 ? 154.370 179.046 171.957 1.00 65.48  ? 115 ARG A N   1 
ATOM 603  C CA  . ARG A 1 116 ? 153.998 180.248 172.681 1.00 65.48  ? 115 ARG A CA  1 
ATOM 604  C C   . ARG A 1 116 ? 152.515 180.522 172.529 1.00 65.48  ? 115 ARG A C   1 
ATOM 605  O O   . ARG A 1 116 ? 151.941 180.309 171.459 1.00 65.48  ? 115 ARG A O   1 
ATOM 606  C CB  . ARG A 1 116 ? 154.788 181.451 172.186 1.00 65.48  ? 115 ARG A CB  1 
ATOM 607  C CG  . ARG A 1 116 ? 154.714 182.623 173.136 1.00 65.48  ? 115 ARG A CG  1 
ATOM 608  C CD  . ARG A 1 116 ? 155.237 183.867 172.491 1.00 65.48  ? 115 ARG A CD  1 
ATOM 609  N NE  . ARG A 1 116 ? 156.664 183.766 172.231 1.00 65.48  ? 115 ARG A NE  1 
ATOM 610  C CZ  . ARG A 1 116 ? 157.306 184.521 171.352 1.00 65.48  ? 115 ARG A CZ  1 
ATOM 611  N NH1 . ARG A 1 116 ? 158.610 184.369 171.173 1.00 65.48  ? 115 ARG A NH1 1 
ATOM 612  N NH2 . ARG A 1 116 ? 156.638 185.425 170.647 1.00 65.48  ? 115 ARG A NH2 1 
ATOM 613  N N   . THR A 1 117 ? 151.898 181.003 173.607 1.00 75.24  ? 116 THR A N   1 
ATOM 614  C CA  . THR A 1 117 ? 150.470 181.273 173.614 1.00 75.24  ? 116 THR A CA  1 
ATOM 615  C C   . THR A 1 117 ? 150.171 182.501 174.461 1.00 75.24  ? 116 THR A C   1 
ATOM 616  O O   . THR A 1 117 ? 150.815 182.738 175.485 1.00 75.24  ? 116 THR A O   1 
ATOM 617  C CB  . THR A 1 117 ? 149.684 180.076 174.150 1.00 75.24  ? 116 THR A CB  1 
ATOM 618  O OG1 . THR A 1 117 ? 150.288 178.866 173.690 1.00 75.24  ? 116 THR A OG1 1 
ATOM 619  C CG2 . THR A 1 117 ? 148.261 180.122 173.643 1.00 75.24  ? 116 THR A CG2 1 
ATOM 620  N N   . LEU A 1 118 ? 149.185 183.277 174.029 1.00 81.42  ? 117 LEU A N   1 
ATOM 621  C CA  . LEU A 1 118 ? 148.708 184.425 174.784 1.00 81.42  ? 117 LEU A CA  1 
ATOM 622  C C   . LEU A 1 118 ? 147.302 184.734 174.302 1.00 81.42  ? 117 LEU A C   1 
ATOM 623  O O   . LEU A 1 118 ? 147.012 184.628 173.110 1.00 81.42  ? 117 LEU A O   1 
ATOM 624  C CB  . LEU A 1 118 ? 149.630 185.633 174.608 1.00 81.42  ? 117 LEU A CB  1 
ATOM 625  C CG  . LEU A 1 118 ? 149.081 187.024 174.919 1.00 81.42  ? 117 LEU A CG  1 
ATOM 626  C CD1 . LEU A 1 118 ? 148.758 187.164 176.356 1.00 81.42  ? 117 LEU A CD1 1 
ATOM 627  C CD2 . LEU A 1 118 ? 150.078 188.079 174.503 1.00 81.42  ? 117 LEU A CD2 1 
ATOM 628  N N   . VAL A 1 119 ? 146.427 185.072 175.239 1.00 87.27  ? 118 VAL A N   1 
ATOM 629  C CA  . VAL A 1 119 ? 144.998 185.134 174.959 1.00 87.27  ? 118 VAL A CA  1 
ATOM 630  C C   . VAL A 1 119 ? 144.423 186.469 175.426 1.00 87.27  ? 118 VAL A C   1 
ATOM 631  O O   . VAL A 1 119 ? 143.338 186.530 176.010 1.00 87.27  ? 118 VAL A O   1 
ATOM 632  C CB  . VAL A 1 119 ? 144.300 183.888 175.547 1.00 87.27  ? 118 VAL A CB  1 
ATOM 633  C CG1 . VAL A 1 119 ? 144.542 183.780 176.994 1.00 87.27  ? 118 VAL A CG1 1 
ATOM 634  C CG2 . VAL A 1 119 ? 142.799 183.820 175.205 1.00 87.27  ? 118 VAL A CG2 1 
ATOM 635  N N   . VAL A 1 120 ? 145.192 187.543 175.248 1.00 90.50  ? 119 VAL A N   1 
ATOM 636  C CA  . VAL A 1 120 ? 144.661 188.883 175.468 1.00 90.50  ? 119 VAL A CA  1 
ATOM 637  C C   . VAL A 1 120 ? 143.330 189.056 174.747 1.00 90.50  ? 119 VAL A C   1 
ATOM 638  O O   . VAL A 1 120 ? 143.120 188.535 173.648 1.00 90.50  ? 119 VAL A O   1 
ATOM 639  C CB  . VAL A 1 120 ? 145.690 189.933 175.016 1.00 90.50  ? 119 VAL A CB  1 
ATOM 640  C CG1 . VAL A 1 120 ? 145.994 189.760 173.557 1.00 90.50  ? 119 VAL A CG1 1 
ATOM 641  C CG2 . VAL A 1 120 ? 145.177 191.332 175.282 1.00 90.50  ? 119 VAL A CG2 1 
ATOM 642  N N   . HIS A 1 121 ? 142.423 189.797 175.376 1.00 97.88  ? 120 HIS A N   1 
ATOM 643  C CA  . HIS A 1 121 ? 141.038 189.879 174.927 1.00 97.88  ? 120 HIS A CA  1 
ATOM 644  C C   . HIS A 1 121 ? 140.542 191.284 175.234 1.00 97.88  ? 120 HIS A C   1 
ATOM 645  O O   . HIS A 1 121 ? 140.518 191.678 176.403 1.00 97.88  ? 120 HIS A O   1 
ATOM 646  C CB  . HIS A 1 121 ? 140.195 188.826 175.652 1.00 97.88  ? 120 HIS A CB  1 
ATOM 647  C CG  . HIS A 1 121 ? 139.155 188.171 174.802 1.00 97.88  ? 120 HIS A CG  1 
ATOM 648  N ND1 . HIS A 1 121 ? 139.417 187.057 174.035 1.00 97.88  ? 120 HIS A ND1 1 
ATOM 649  C CD2 . HIS A 1 121 ? 137.843 188.450 174.624 1.00 97.88  ? 120 HIS A CD2 1 
ATOM 650  C CE1 . HIS A 1 121 ? 138.315 186.687 173.408 1.00 97.88  ? 120 HIS A CE1 1 
ATOM 651  N NE2 . HIS A 1 121 ? 137.345 187.516 173.749 1.00 97.88  ? 120 HIS A NE2 1 
ATOM 652  N N   . GLU A 1 122 ? 140.160 192.047 174.209 1.00 110.31 ? 121 GLU A N   1 
ATOM 653  C CA  . GLU A 1 122 ? 139.836 193.447 174.445 1.00 110.31 ? 121 GLU A CA  1 
ATOM 654  C C   . GLU A 1 122 ? 138.746 193.943 173.507 1.00 110.31 ? 121 GLU A C   1 
ATOM 655  O O   . GLU A 1 122 ? 138.467 193.344 172.469 1.00 110.31 ? 121 GLU A O   1 
ATOM 656  C CB  . GLU A 1 122 ? 141.077 194.327 174.320 1.00 110.31 ? 121 GLU A CB  1 
ATOM 657  C CG  . GLU A 1 122 ? 141.726 194.618 175.652 1.00 110.31 ? 121 GLU A CG  1 
ATOM 658  C CD  . GLU A 1 122 ? 143.005 195.400 175.515 1.00 110.31 ? 121 GLU A CD  1 
ATOM 659  O OE1 . GLU A 1 122 ? 143.598 195.377 174.418 1.00 110.31 ? 121 GLU A OE1 1 
ATOM 660  O OE2 . GLU A 1 122 ? 143.418 196.039 176.503 1.00 110.31 ? 121 GLU A OE2 1 
ATOM 661  N N   . LYS A 1 123 ? 138.135 195.060 173.903 1.00 121.42 ? 122 LYS A N   1 
ATOM 662  C CA  . LYS A 1 123 ? 137.054 195.727 173.183 1.00 121.42 ? 122 LYS A CA  1 
ATOM 663  C C   . LYS A 1 123 ? 137.022 197.175 173.646 1.00 121.42 ? 122 LYS A C   1 
ATOM 664  O O   . LYS A 1 123 ? 137.506 197.498 174.732 1.00 121.42 ? 122 LYS A O   1 
ATOM 665  C CB  . LYS A 1 123 ? 135.707 195.051 173.439 1.00 121.42 ? 122 LYS A CB  1 
ATOM 666  C CG  . LYS A 1 123 ? 135.497 194.648 174.894 1.00 121.42 ? 122 LYS A CG  1 
ATOM 667  C CD  . LYS A 1 123 ? 134.173 193.936 175.090 1.00 121.42 ? 122 LYS A CD  1 
ATOM 668  C CE  . LYS A 1 123 ? 133.894 193.652 176.552 1.00 121.42 ? 122 LYS A CE  1 
ATOM 669  N NZ  . LYS A 1 123 ? 134.981 192.862 177.184 1.00 121.42 ? 122 LYS A NZ  1 
ATOM 670  N N   . ALA A 1 124 ? 136.429 198.048 172.830 1.00 133.72 ? 123 ALA A N   1 
ATOM 671  C CA  . ALA A 1 124 ? 136.609 199.483 173.027 1.00 133.72 ? 123 ALA A CA  1 
ATOM 672  C C   . ALA A 1 124 ? 135.358 200.211 173.508 1.00 133.72 ? 123 ALA A C   1 
ATOM 673  O O   . ALA A 1 124 ? 135.394 200.839 174.569 1.00 133.72 ? 123 ALA A O   1 
ATOM 674  C CB  . ALA A 1 124 ? 137.124 200.103 171.721 1.00 133.72 ? 123 ALA A CB  1 
ATOM 675  N N   . ASP A 1 125 ? 134.266 200.186 172.738 1.00 141.05 ? 124 ASP A N   1 
ATOM 676  C CA  . ASP A 1 125 ? 132.923 200.624 173.139 1.00 141.05 ? 124 ASP A CA  1 
ATOM 677  C C   . ASP A 1 125 ? 132.816 201.813 174.099 1.00 141.05 ? 124 ASP A C   1 
ATOM 678  O O   . ASP A 1 125 ? 132.230 201.677 175.177 1.00 141.05 ? 124 ASP A O   1 
ATOM 679  C CB  . ASP A 1 125 ? 132.150 199.436 173.728 1.00 141.05 ? 124 ASP A CB  1 
ATOM 680  C CG  . ASP A 1 125 ? 132.990 198.574 174.645 1.00 141.05 ? 124 ASP A CG  1 
ATOM 681  O OD1 . ASP A 1 125 ? 133.600 199.113 175.586 1.00 141.05 ? 124 ASP A OD1 1 
ATOM 682  O OD2 . ASP A 1 125 ? 133.050 197.350 174.412 1.00 141.05 ? 124 ASP A OD2 1 
ATOM 683  N N   . ASP A 1 126 ? 133.339 202.978 173.724 1.00 144.20 ? 125 ASP A N   1 
ATOM 684  C CA  . ASP A 1 126 ? 133.184 204.181 174.536 1.00 144.20 ? 125 ASP A CA  1 
ATOM 685  C C   . ASP A 1 126 ? 131.934 204.952 174.121 1.00 144.20 ? 125 ASP A C   1 
ATOM 686  O O   . ASP A 1 126 ? 131.447 204.835 172.994 1.00 144.20 ? 125 ASP A O   1 
ATOM 687  C CB  . ASP A 1 126 ? 134.413 205.089 174.412 1.00 144.20 ? 125 ASP A CB  1 
ATOM 688  C CG  . ASP A 1 126 ? 134.418 206.235 175.426 1.00 144.20 ? 125 ASP A CG  1 
ATOM 689  O OD1 . ASP A 1 126 ? 133.386 206.914 175.596 1.00 144.20 ? 125 ASP A OD1 1 
ATOM 690  O OD2 . ASP A 1 126 ? 135.472 206.466 176.049 1.00 144.20 ? 125 ASP A OD2 1 
ATOM 691  N N   . LEU A 1 127 ? 131.419 205.761 175.055 1.00 144.12 ? 126 LEU A N   1 
ATOM 692  C CA  . LEU A 1 127 ? 130.235 206.576 174.778 1.00 144.12 ? 126 LEU A CA  1 
ATOM 693  C C   . LEU A 1 127 ? 130.224 207.797 175.703 1.00 144.12 ? 126 LEU A C   1 
ATOM 694  O O   . LEU A 1 127 ? 129.794 207.703 176.853 1.00 144.12 ? 126 LEU A O   1 
ATOM 695  C CB  . LEU A 1 127 ? 128.961 205.747 174.908 1.00 144.12 ? 126 LEU A CB  1 
ATOM 696  C CG  . LEU A 1 127 ? 128.529 205.091 176.221 1.00 144.12 ? 126 LEU A CG  1 
ATOM 697  C CD1 . LEU A 1 127 ? 127.044 204.794 176.198 1.00 144.12 ? 126 LEU A CD1 1 
ATOM 698  C CD2 . LEU A 1 127 ? 129.319 203.815 176.453 1.00 144.12 ? 126 LEU A CD2 1 
ATOM 699  N N   . GLY A 1 128 ? 130.654 208.940 175.178 1.00 142.22 ? 127 GLY A N   1 
ATOM 700  C CA  . GLY A 1 128 ? 130.735 210.135 175.994 1.00 142.22 ? 127 GLY A CA  1 
ATOM 701  C C   . GLY A 1 128 ? 131.823 211.080 175.534 1.00 142.22 ? 127 GLY A C   1 
ATOM 702  O O   . GLY A 1 128 ? 131.837 211.493 174.373 1.00 142.22 ? 127 GLY A O   1 
ATOM 703  N N   . LYS A 1 129 ? 132.728 211.445 176.439 1.00 141.15 ? 128 LYS A N   1 
ATOM 704  C CA  . LYS A 1 129 ? 133.900 212.258 176.129 1.00 141.15 ? 128 LYS A CA  1 
ATOM 705  C C   . LYS A 1 129 ? 135.158 211.579 176.645 1.00 141.15 ? 128 LYS A C   1 
ATOM 706  O O   . LYS A 1 129 ? 135.978 212.174 177.346 1.00 141.15 ? 128 LYS A O   1 
ATOM 707  C CB  . LYS A 1 129 ? 133.783 213.660 176.714 1.00 141.15 ? 128 LYS A CB  1 
ATOM 708  C CG  . LYS A 1 129 ? 132.598 214.445 176.207 1.00 141.15 ? 128 LYS A CG  1 
ATOM 709  C CD  . LYS A 1 129 ? 132.908 215.118 174.889 1.00 141.15 ? 128 LYS A CD  1 
ATOM 710  C CE  . LYS A 1 129 ? 131.740 215.975 174.430 1.00 141.15 ? 128 LYS A CE  1 
ATOM 711  N NZ  . LYS A 1 129 ? 132.013 216.646 173.130 1.00 141.15 ? 128 LYS A NZ  1 
ATOM 712  N N   . GLY A 1 130 ? 135.319 210.305 176.305 1.00 141.36 ? 129 GLY A N   1 
ATOM 713  C CA  . GLY A 1 130 ? 136.419 209.514 176.817 1.00 141.36 ? 129 GLY A CA  1 
ATOM 714  C C   . GLY A 1 130 ? 137.555 209.366 175.830 1.00 141.36 ? 129 GLY A C   1 
ATOM 715  O O   . GLY A 1 130 ? 138.414 210.246 175.720 1.00 141.36 ? 129 GLY A O   1 
ATOM 716  N N   . GLY A 1 131 ? 137.577 208.241 175.123 1.00 140.09 ? 130 GLY A N   1 
ATOM 717  C CA  . GLY A 1 131 ? 138.628 207.945 174.171 1.00 140.09 ? 130 GLY A CA  1 
ATOM 718  C C   . GLY A 1 131 ? 139.366 206.684 174.556 1.00 140.09 ? 130 GLY A C   1 
ATOM 719  O O   . GLY A 1 131 ? 140.187 206.682 175.477 1.00 140.09 ? 130 GLY A O   1 
ATOM 720  N N   . ASN A 1 132 ? 139.090 205.605 173.836 1.00 134.70 ? 131 ASN A N   1 
ATOM 721  C CA  . ASN A 1 132 ? 139.489 204.262 174.233 1.00 134.70 ? 131 ASN A CA  1 
ATOM 722  C C   . ASN A 1 132 ? 140.680 203.774 173.417 1.00 134.70 ? 131 ASN A C   1 
ATOM 723  O O   . ASN A 1 132 ? 140.599 203.631 172.191 1.00 134.70 ? 131 ASN A O   1 
ATOM 724  C CB  . ASN A 1 132 ? 138.290 203.323 174.141 1.00 134.70 ? 131 ASN A CB  1 
ATOM 725  C CG  . ASN A 1 132 ? 137.407 203.636 172.963 1.00 134.70 ? 131 ASN A CG  1 
ATOM 726  O OD1 . ASN A 1 132 ? 137.726 204.504 172.160 1.00 134.70 ? 131 ASN A OD1 1 
ATOM 727  N ND2 . ASN A 1 132 ? 136.269 202.970 172.880 1.00 134.70 ? 131 ASN A ND2 1 
ATOM 728  N N   . GLU A 1 133 ? 141.777 203.515 174.123 1.00 123.96 ? 132 GLU A N   1 
ATOM 729  C CA  . GLU A 1 133 ? 143.055 203.084 173.584 1.00 123.96 ? 132 GLU A CA  1 
ATOM 730  C C   . GLU A 1 133 ? 143.516 201.891 174.404 1.00 123.96 ? 132 GLU A C   1 
ATOM 731  O O   . GLU A 1 133 ? 143.256 201.829 175.607 1.00 123.96 ? 132 GLU A O   1 
ATOM 732  C CB  . GLU A 1 133 ? 144.084 204.206 173.702 1.00 123.96 ? 132 GLU A CB  1 
ATOM 733  C CG  . GLU A 1 133 ? 145.425 203.949 173.083 1.00 123.96 ? 132 GLU A CG  1 
ATOM 734  C CD  . GLU A 1 133 ? 145.420 204.223 171.613 1.00 123.96 ? 132 GLU A CD  1 
ATOM 735  O OE1 . GLU A 1 133 ? 144.609 205.073 171.192 1.00 123.96 ? 132 GLU A OE1 1 
ATOM 736  O OE2 . GLU A 1 133 ? 146.229 203.606 170.890 1.00 123.96 ? 132 GLU A OE2 1 
ATOM 737  N N   . GLU A 1 134 ? 144.193 200.941 173.766 1.00 117.01 ? 133 GLU A N   1 
ATOM 738  C CA  . GLU A 1 134 ? 144.674 199.774 174.495 1.00 117.01 ? 133 GLU A CA  1 
ATOM 739  C C   . GLU A 1 134 ? 145.934 199.228 173.842 1.00 117.01 ? 133 GLU A C   1 
ATOM 740  O O   . GLU A 1 134 ? 146.035 199.174 172.613 1.00 117.01 ? 133 GLU A O   1 
ATOM 741  C CB  . GLU A 1 134 ? 143.600 198.688 174.582 1.00 117.01 ? 133 GLU A CB  1 
ATOM 742  C CG  . GLU A 1 134 ? 142.967 198.298 173.265 1.00 117.01 ? 133 GLU A CG  1 
ATOM 743  C CD  . GLU A 1 134 ? 141.637 198.984 173.029 1.00 117.01 ? 133 GLU A CD  1 
ATOM 744  O OE1 . GLU A 1 134 ? 141.411 200.062 173.614 1.00 117.01 ? 133 GLU A OE1 1 
ATOM 745  O OE2 . GLU A 1 134 ? 140.811 198.431 172.274 1.00 117.01 ? 133 GLU A OE2 1 
ATOM 746  N N   . SER A 1 135 ? 146.890 198.827 174.676 1.00 106.23 ? 134 SER A N   1 
ATOM 747  C CA  . SER A 1 135 ? 148.237 198.502 174.216 1.00 106.23 ? 134 SER A CA  1 
ATOM 748  C C   . SER A 1 135 ? 148.761 197.157 174.700 1.00 106.23 ? 134 SER A C   1 
ATOM 749  O O   . SER A 1 135 ? 149.505 196.504 173.968 1.00 106.23 ? 134 SER A O   1 
ATOM 750  C CB  . SER A 1 135 ? 149.186 199.622 174.654 1.00 106.23 ? 134 SER A CB  1 
ATOM 751  O OG  . SER A 1 135 ? 148.970 199.963 176.011 1.00 106.23 ? 134 SER A OG  1 
ATOM 752  N N   . THR A 1 136 ? 148.434 196.759 175.926 1.00 101.21 ? 135 THR A N   1 
ATOM 753  C CA  . THR A 1 136 ? 148.796 195.468 176.529 1.00 101.21 ? 135 THR A CA  1 
ATOM 754  C C   . THR A 1 136 ? 150.177 194.959 176.109 1.00 101.21 ? 135 THR A C   1 
ATOM 755  O O   . THR A 1 136 ? 150.338 193.854 175.595 1.00 101.21 ? 135 THR A O   1 
ATOM 756  C CB  . THR A 1 136 ? 147.722 194.403 176.282 1.00 101.21 ? 135 THR A CB  1 
ATOM 757  O OG1 . THR A 1 136 ? 148.159 193.156 176.836 1.00 101.21 ? 135 THR A OG1 1 
ATOM 758  C CG2 . THR A 1 136 ? 147.413 194.217 174.838 1.00 101.21 ? 135 THR A CG2 1 
ATOM 759  N N   . LYS A 1 137 ? 151.190 195.770 176.382 1.00 99.58  ? 136 LYS A N   1 
ATOM 760  C CA  . LYS A 1 137 ? 152.554 195.339 176.119 1.00 99.58  ? 136 LYS A CA  1 
ATOM 761  C C   . LYS A 1 137 ? 152.978 194.275 177.128 1.00 99.58  ? 136 LYS A C   1 
ATOM 762  O O   . LYS A 1 137 ? 152.392 194.141 178.203 1.00 99.58  ? 136 LYS A O   1 
ATOM 763  C CB  . LYS A 1 137 ? 153.504 196.534 176.168 1.00 99.58  ? 136 LYS A CB  1 
ATOM 764  C CG  . LYS A 1 137 ? 154.317 196.674 177.444 1.00 99.58  ? 136 LYS A CG  1 
ATOM 765  C CD  . LYS A 1 137 ? 155.214 197.901 177.367 1.00 99.58  ? 136 LYS A CD  1 
ATOM 766  C CE  . LYS A 1 137 ? 156.179 197.986 178.534 1.00 99.58  ? 136 LYS A CE  1 
ATOM 767  N NZ  . LYS A 1 137 ? 157.017 196.767 178.687 1.00 99.58  ? 136 LYS A NZ  1 
ATOM 768  N N   . THR A 1 138 ? 154.011 193.506 176.776 1.00 97.72  ? 137 THR A N   1 
ATOM 769  C CA  . THR A 1 138 ? 154.519 192.470 177.670 1.00 97.72  ? 137 THR A CA  1 
ATOM 770  C C   . THR A 1 138 ? 155.899 192.800 178.223 1.00 97.72  ? 137 THR A C   1 
ATOM 771  O O   . THR A 1 138 ? 156.068 192.922 179.438 1.00 97.72  ? 137 THR A O   1 
ATOM 772  C CB  . THR A 1 138 ? 154.578 191.116 176.956 1.00 97.72  ? 137 THR A CB  1 
ATOM 773  O OG1 . THR A 1 138 ? 155.712 191.103 176.084 1.00 97.72  ? 137 THR A OG1 1 
ATOM 774  C CG2 . THR A 1 138 ? 153.326 190.876 176.141 1.00 97.72  ? 137 THR A CG2 1 
ATOM 775  N N   . GLY A 1 139 ? 156.892 192.977 177.364 1.00 96.13  ? 138 GLY A N   1 
ATOM 776  C CA  . GLY A 1 139 ? 158.244 193.139 177.856 1.00 96.13  ? 138 GLY A CA  1 
ATOM 777  C C   . GLY A 1 139 ? 159.222 192.232 177.148 1.00 96.13  ? 138 GLY A C   1 
ATOM 778  O O   . GLY A 1 139 ? 158.918 191.066 176.889 1.00 96.13  ? 138 GLY A O   1 
ATOM 779  N N   . ASN A 1 140 ? 160.402 192.756 176.832 1.00 96.03  ? 139 ASN A N   1 
ATOM 780  C CA  . ASN A 1 140 ? 161.357 192.018 176.025 1.00 96.03  ? 139 ASN A CA  1 
ATOM 781  C C   . ASN A 1 140 ? 161.991 190.884 176.826 1.00 96.03  ? 139 ASN A C   1 
ATOM 782  O O   . ASN A 1 140 ? 161.894 190.808 178.053 1.00 96.03  ? 139 ASN A O   1 
ATOM 783  C CB  . ASN A 1 140 ? 162.451 192.943 175.499 1.00 96.03  ? 139 ASN A CB  1 
ATOM 784  C CG  . ASN A 1 140 ? 161.935 193.940 174.497 1.00 96.03  ? 139 ASN A CG  1 
ATOM 785  O OD1 . ASN A 1 140 ? 160.827 193.806 173.983 1.00 96.03  ? 139 ASN A OD1 1 
ATOM 786  N ND2 . ASN A 1 140 ? 162.744 194.950 174.203 1.00 96.03  ? 139 ASN A ND2 1 
ATOM 787  N N   . ALA A 1 141 ? 162.658 189.994 176.100 1.00 89.36  ? 140 ALA A N   1 
ATOM 788  C CA  . ALA A 1 141 ? 163.428 188.929 176.716 1.00 89.36  ? 140 ALA A CA  1 
ATOM 789  C C   . ALA A 1 141 ? 164.605 188.604 175.814 1.00 89.36  ? 140 ALA A C   1 
ATOM 790  O O   . ALA A 1 141 ? 164.607 188.921 174.624 1.00 89.36  ? 140 ALA A O   1 
ATOM 791  C CB  . ALA A 1 141 ? 162.577 187.681 176.960 1.00 89.36  ? 140 ALA A CB  1 
ATOM 792  N N   . GLY A 1 142 ? 165.606 187.965 176.396 1.00 81.74  ? 141 GLY A N   1 
ATOM 793  C CA  . GLY A 1 142 ? 166.749 187.537 175.619 1.00 81.74  ? 141 GLY A CA  1 
ATOM 794  C C   . GLY A 1 142 ? 167.703 186.767 176.495 1.00 81.74  ? 141 GLY A C   1 
ATOM 795  O O   . GLY A 1 142 ? 167.450 186.544 177.682 1.00 81.74  ? 141 GLY A O   1 
ATOM 796  N N   . SER A 1 143 ? 168.824 186.370 175.891 1.00 76.09  ? 142 SER A N   1 
ATOM 797  C CA  . SER A 1 143 ? 169.895 185.660 176.587 1.00 76.09  ? 142 SER A CA  1 
ATOM 798  C C   . SER A 1 143 ? 169.369 184.362 177.206 1.00 76.09  ? 142 SER A C   1 
ATOM 799  O O   . SER A 1 143 ? 169.268 184.199 178.425 1.00 76.09  ? 142 SER A O   1 
ATOM 800  C CB  . SER A 1 143 ? 170.558 186.549 177.643 1.00 76.09  ? 142 SER A CB  1 
ATOM 801  O OG  . SER A 1 143 ? 169.624 186.960 178.620 1.00 76.09  ? 142 SER A OG  1 
ATOM 802  N N   . ARG A 1 144 ? 168.983 183.461 176.307 1.00 69.87  ? 143 ARG A N   1 
ATOM 803  C CA  . ARG A 1 144 ? 168.750 182.068 176.653 1.00 69.87  ? 143 ARG A CA  1 
ATOM 804  C C   . ARG A 1 144 ? 169.351 181.195 175.570 1.00 69.87  ? 143 ARG A C   1 
ATOM 805  O O   . ARG A 1 144 ? 169.421 181.590 174.411 1.00 69.87  ? 143 ARG A O   1 
ATOM 806  C CB  . ARG A 1 144 ? 167.266 181.745 176.820 1.00 69.87  ? 143 ARG A CB  1 
ATOM 807  C CG  . ARG A 1 144 ? 166.475 181.805 175.544 1.00 69.87  ? 143 ARG A CG  1 
ATOM 808  C CD  . ARG A 1 144 ? 165.021 181.566 175.831 1.00 69.87  ? 143 ARG A CD  1 
ATOM 809  N NE  . ARG A 1 144 ? 164.174 182.378 174.974 1.00 69.87  ? 143 ARG A NE  1 
ATOM 810  C CZ  . ARG A 1 144 ? 162.872 182.539 175.158 1.00 69.87  ? 143 ARG A CZ  1 
ATOM 811  N NH1 . ARG A 1 144 ? 162.268 181.940 176.174 1.00 69.87  ? 143 ARG A NH1 1 
ATOM 812  N NH2 . ARG A 1 144 ? 162.178 183.299 174.327 1.00 69.87  ? 143 ARG A NH2 1 
ATOM 813  N N   . LEU A 1 145 ? 169.811 180.014 175.956 1.00 65.55  ? 144 LEU A N   1 
ATOM 814  C CA  . LEU A 1 145 ? 170.260 179.071 174.948 1.00 65.55  ? 144 LEU A CA  1 
ATOM 815  C C   . LEU A 1 145 ? 170.091 177.671 175.504 1.00 65.55  ? 144 LEU A C   1 
ATOM 816  O O   . LEU A 1 145 ? 170.126 177.464 176.718 1.00 65.55  ? 144 LEU A O   1 
ATOM 817  C CB  . LEU A 1 145 ? 171.706 179.338 174.530 1.00 65.55  ? 144 LEU A CB  1 
ATOM 818  C CG  . LEU A 1 145 ? 172.248 178.610 173.303 1.00 65.55  ? 144 LEU A CG  1 
ATOM 819  C CD1 . LEU A 1 145 ? 173.242 179.474 172.594 1.00 65.55  ? 144 LEU A CD1 1 
ATOM 820  C CD2 . LEU A 1 145 ? 172.906 177.324 173.690 1.00 65.55  ? 144 LEU A CD2 1 
ATOM 821  N N   . ALA A 1 146 ? 169.872 176.721 174.605 1.00 60.89  ? 145 ALA A N   1 
ATOM 822  C CA  . ALA A 1 146 ? 169.632 175.335 174.974 1.00 60.89  ? 145 ALA A CA  1 
ATOM 823  C C   . ALA A 1 146 ? 170.724 174.479 174.364 1.00 60.89  ? 145 ALA A C   1 
ATOM 824  O O   . ALA A 1 146 ? 170.910 174.491 173.144 1.00 60.89  ? 145 ALA A O   1 
ATOM 825  C CB  . ALA A 1 146 ? 168.260 174.876 174.492 1.00 60.89  ? 145 ALA A CB  1 
ATOM 826  N N   . CYS A 1 147 ? 171.443 173.740 175.202 1.00 60.51  ? 146 CYS A N   1 
ATOM 827  C CA  . CYS A 1 147 ? 172.530 172.914 174.707 1.00 60.51  ? 146 CYS A CA  1 
ATOM 828  C C   . CYS A 1 147 ? 172.389 171.491 175.214 1.00 60.51  ? 146 CYS A C   1 
ATOM 829  O O   . CYS A 1 147 ? 172.073 171.264 176.384 1.00 60.51  ? 146 CYS A O   1 
ATOM 830  C CB  . CYS A 1 147 ? 173.897 173.474 175.110 1.00 60.51  ? 146 CYS A CB  1 
ATOM 831  S SG  . CYS A 1 147 ? 174.539 172.941 176.696 1.00 60.51  ? 146 CYS A SG  1 
ATOM 832  N N   . GLY A 1 148 ? 172.615 170.537 174.318 1.00 52.64  ? 147 GLY A N   1 
ATOM 833  C CA  . GLY A 1 148 ? 172.686 169.147 174.712 1.00 52.64  ? 147 GLY A CA  1 
ATOM 834  C C   . GLY A 1 148 ? 171.540 168.282 174.246 1.00 52.64  ? 147 GLY A C   1 
ATOM 835  O O   . GLY A 1 148 ? 171.277 168.172 173.048 1.00 52.64  ? 147 GLY A O   1 
ATOM 836  N N   . VAL A 1 149 ? 170.862 167.647 175.195 1.00 47.61  ? 148 VAL A N   1 
ATOM 837  C CA  . VAL A 1 149 ? 169.743 166.759 174.916 1.00 47.61  ? 148 VAL A CA  1 
ATOM 838  C C   . VAL A 1 149 ? 168.565 167.204 175.776 1.00 47.61  ? 148 VAL A C   1 
ATOM 839  O O   . VAL A 1 149 ? 168.608 167.104 177.006 1.00 47.61  ? 148 VAL A O   1 
ATOM 840  C CB  . VAL A 1 149 ? 170.103 165.285 175.150 1.00 47.61  ? 148 VAL A CB  1 
ATOM 841  C CG1 . VAL A 1 149 ? 170.695 165.065 176.531 1.00 47.61  ? 148 VAL A CG1 1 
ATOM 842  C CG2 . VAL A 1 149 ? 168.894 164.412 174.931 1.00 47.61  ? 148 VAL A CG2 1 
ATOM 843  N N   . ILE A 1 150 ? 167.519 167.718 175.129 1.00 47.20  ? 149 ILE A N   1 
ATOM 844  C CA  . ILE A 1 150 ? 166.484 168.454 175.837 1.00 47.20  ? 149 ILE A CA  1 
ATOM 845  C C   . ILE A 1 150 ? 165.103 167.835 175.684 1.00 47.20  ? 149 ILE A C   1 
ATOM 846  O O   . ILE A 1 150 ? 164.491 167.433 176.672 1.00 47.20  ? 149 ILE A O   1 
ATOM 847  C CB  . ILE A 1 150 ? 166.455 169.915 175.383 1.00 47.20  ? 149 ILE A CB  1 
ATOM 848  C CG1 . ILE A 1 150 ? 167.857 170.500 175.415 1.00 47.20  ? 149 ILE A CG1 1 
ATOM 849  C CG2 . ILE A 1 150 ? 165.588 170.700 176.317 1.00 47.20  ? 149 ILE A CG2 1 
ATOM 850  C CD1 . ILE A 1 150 ? 168.372 170.731 176.795 1.00 47.20  ? 149 ILE A CD1 1 
ATOM 851  N N   . GLY A 1 151 ? 164.592 167.739 174.469 1.00 46.58  ? 150 GLY A N   1 
ATOM 852  C CA  . GLY A 1 151 ? 163.173 167.464 174.364 1.00 46.58  ? 150 GLY A CA  1 
ATOM 853  C C   . GLY A 1 151 ? 162.424 168.670 173.845 1.00 46.58  ? 150 GLY A C   1 
ATOM 854  O O   . GLY A 1 151 ? 162.410 168.916 172.636 1.00 46.58  ? 150 GLY A O   1 
ATOM 855  N N   . ILE A 1 152 ? 161.767 169.411 174.729 1.00 47.26  ? 151 ILE A N   1 
ATOM 856  C CA  . ILE A 1 152 ? 161.224 170.719 174.392 1.00 47.26  ? 151 ILE A CA  1 
ATOM 857  C C   . ILE A 1 152 ? 162.181 171.774 174.906 1.00 47.26  ? 151 ILE A C   1 
ATOM 858  O O   . ILE A 1 152 ? 162.430 171.862 176.113 1.00 47.26  ? 151 ILE A O   1 
ATOM 859  C CB  . ILE A 1 152 ? 159.832 170.934 174.989 1.00 47.26  ? 151 ILE A CB  1 
ATOM 860  C CG1 . ILE A 1 152 ? 158.932 169.754 174.685 1.00 47.26  ? 151 ILE A CG1 1 
ATOM 861  C CG2 . ILE A 1 152 ? 159.240 172.181 174.423 1.00 47.26  ? 151 ILE A CG2 1 
ATOM 862  C CD1 . ILE A 1 152 ? 158.012 169.451 175.806 1.00 47.26  ? 151 ILE A CD1 1 
ATOM 863  N N   . ALA A 1 153 ? 162.715 172.578 173.997 1.00 51.29  ? 152 ALA A N   1 
ATOM 864  C CA  . ALA A 1 153 ? 163.575 173.700 174.342 1.00 51.29  ? 152 ALA A CA  1 
ATOM 865  C C   . ALA A 1 153 ? 162.916 174.965 173.833 1.00 51.29  ? 152 ALA A C   1 
ATOM 866  O O   . ALA A 1 153 ? 162.706 175.113 172.627 1.00 51.29  ? 152 ALA A O   1 
ATOM 867  C CB  . ALA A 1 153 ? 164.966 173.542 173.737 1.00 51.29  ? 152 ALA A CB  1 
ATOM 868  N N   . GLN A 1 154 ? 162.588 175.866 174.745 1.00 54.79  ? 153 GLN A N   1 
ATOM 869  C CA  . GLN A 1 154 ? 161.926 177.103 174.376 1.00 54.79  ? 153 GLN A CA  1 
ATOM 870  C C   . GLN A 1 154 ? 162.235 178.210 175.376 1.00 54.79  ? 153 GLN A C   1 
ATOM 871  O O   . GLN A 1 154 ? 162.781 179.254 175.014 1.00 54.79  ? 153 GLN A O   1 
ATOM 872  C CB  . GLN A 1 154 ? 160.424 176.883 174.280 1.00 54.79  ? 153 GLN A CB  1 
ATOM 873  C CG  . GLN A 1 154 ? 159.827 176.322 175.537 1.00 54.79  ? 153 GLN A CG  1 
ATOM 874  C CD  . GLN A 1 154 ? 158.451 175.757 175.319 1.00 54.79  ? 153 GLN A CD  1 
ATOM 875  O OE1 . GLN A 1 154 ? 158.025 175.547 174.187 1.00 54.79  ? 153 GLN A OE1 1 
ATOM 876  N NE2 . GLN A 1 154 ? 157.741 175.510 176.406 1.00 54.79  ? 153 GLN A NE2 1 
ATOM 877  N N   . LYS B 1 4   ? 192.288 130.957 168.284 1.00 73.43  ? 3   LYS B N   1 
ATOM 878  C CA  . LYS B 1 4   ? 191.116 131.602 168.867 1.00 73.43  ? 3   LYS B CA  1 
ATOM 879  C C   . LYS B 1 4   ? 191.466 132.957 169.465 1.00 73.43  ? 3   LYS B C   1 
ATOM 880  O O   . LYS B 1 4   ? 191.562 133.094 170.680 1.00 73.43  ? 3   LYS B O   1 
ATOM 881  C CB  . LYS B 1 4   ? 190.498 130.707 169.938 1.00 73.43  ? 3   LYS B CB  1 
ATOM 882  C CG  . LYS B 1 4   ? 189.139 131.161 170.403 1.00 73.43  ? 3   LYS B CG  1 
ATOM 883  C CD  . LYS B 1 4   ? 188.169 131.209 169.245 1.00 73.43  ? 3   LYS B CD  1 
ATOM 884  C CE  . LYS B 1 4   ? 187.921 129.827 168.687 1.00 73.43  ? 3   LYS B CE  1 
ATOM 885  N NZ  . LYS B 1 4   ? 187.193 128.981 169.659 1.00 73.43  ? 3   LYS B NZ  1 
ATOM 886  N N   . ALA B 1 5   ? 191.660 133.954 168.611 1.00 70.99  ? 4   ALA B N   1 
ATOM 887  C CA  . ALA B 1 5   ? 192.021 135.292 169.061 1.00 70.99  ? 4   ALA B CA  1 
ATOM 888  C C   . ALA B 1 5   ? 191.747 136.264 167.924 1.00 70.99  ? 4   ALA B C   1 
ATOM 889  O O   . ALA B 1 5   ? 191.195 135.890 166.887 1.00 70.99  ? 4   ALA B O   1 
ATOM 890  C CB  . ALA B 1 5   ? 193.480 135.343 169.520 1.00 70.99  ? 4   ALA B CB  1 
ATOM 891  N N   . VAL B 1 6   ? 192.127 137.522 168.122 1.00 69.41  ? 5   VAL B N   1 
ATOM 892  C CA  . VAL B 1 6   ? 191.973 138.556 167.113 1.00 69.41  ? 5   VAL B CA  1 
ATOM 893  C C   . VAL B 1 6   ? 193.306 138.920 166.479 1.00 69.41  ? 5   VAL B C   1 
ATOM 894  O O   . VAL B 1 6   ? 193.378 139.158 165.272 1.00 69.41  ? 5   VAL B O   1 
ATOM 895  C CB  . VAL B 1 6   ? 191.289 139.800 167.716 1.00 69.41  ? 5   VAL B CB  1 
ATOM 896  C CG1 . VAL B 1 6   ? 191.014 140.830 166.658 1.00 69.41  ? 5   VAL B CG1 1 
ATOM 897  C CG2 . VAL B 1 6   ? 189.995 139.396 168.367 1.00 69.41  ? 5   VAL B CG2 1 
ATOM 898  N N   . CYS B 1 7   ? 194.367 138.966 167.275 1.00 78.23  ? 6   CYS B N   1 
ATOM 899  C CA  . CYS B 1 7   ? 195.718 139.106 166.761 1.00 78.23  ? 6   CYS B CA  1 
ATOM 900  C C   . CYS B 1 7   ? 196.613 138.116 167.481 1.00 78.23  ? 6   CYS B C   1 
ATOM 901  O O   . CYS B 1 7   ? 196.378 137.776 168.643 1.00 78.23  ? 6   CYS B O   1 
ATOM 902  C CB  . CYS B 1 7   ? 196.270 140.516 166.957 1.00 78.23  ? 6   CYS B CB  1 
ATOM 903  S SG  . CYS B 1 7   ? 196.912 140.813 168.618 1.00 78.23  ? 6   CYS B SG  1 
ATOM 904  N N   . VAL B 1 8   ? 197.633 137.640 166.779 1.00 78.93  ? 7   VAL B N   1 
ATOM 905  C CA  . VAL B 1 8   ? 198.707 136.874 167.391 1.00 78.93  ? 7   VAL B CA  1 
ATOM 906  C C   . VAL B 1 8   ? 200.003 137.613 167.111 1.00 78.93  ? 7   VAL B C   1 
ATOM 907  O O   . VAL B 1 8   ? 200.237 138.068 165.986 1.00 78.93  ? 7   VAL B O   1 
ATOM 908  C CB  . VAL B 1 8   ? 198.750 135.423 166.880 1.00 78.93  ? 7   VAL B CB  1 
ATOM 909  C CG1 . VAL B 1 8   ? 197.375 134.797 166.976 1.00 78.93  ? 7   VAL B CG1 1 
ATOM 910  C CG2 . VAL B 1 8   ? 199.255 135.352 165.464 1.00 78.93  ? 7   VAL B CG2 1 
ATOM 911  N N   . LEU B 1 9   ? 200.818 137.783 168.144 1.00 82.92  ? 8   LEU B N   1 
ATOM 912  C CA  . LEU B 1 9   ? 202.025 138.587 168.039 1.00 82.92  ? 8   LEU B CA  1 
ATOM 913  C C   . LEU B 1 9   ? 203.236 137.732 168.367 1.00 82.92  ? 8   LEU B C   1 
ATOM 914  O O   . LEU B 1 9   ? 203.318 137.148 169.452 1.00 82.92  ? 8   LEU B O   1 
ATOM 915  C CB  . LEU B 1 9   ? 201.959 139.804 168.957 1.00 82.92  ? 8   LEU B CB  1 
ATOM 916  C CG  . LEU B 1 9   ? 203.111 140.791 168.749 1.00 82.92  ? 8   LEU B CG  1 
ATOM 917  C CD1 . LEU B 1 9   ? 203.458 140.910 167.297 1.00 82.92  ? 8   LEU B CD1 1 
ATOM 918  C CD2 . LEU B 1 9   ? 202.777 142.150 169.286 1.00 82.92  ? 8   LEU B CD2 1 
ATOM 919  N N   . LYS B 1 10  ? 204.167 137.668 167.433 1.00 84.58  ? 9   LYS B N   1 
ATOM 920  C CA  . LYS B 1 10  ? 205.425 136.969 167.618 1.00 84.58  ? 9   LYS B CA  1 
ATOM 921  C C   . LYS B 1 10  ? 206.623 137.891 167.539 1.00 84.58  ? 9   LYS B C   1 
ATOM 922  O O   . LYS B 1 10  ? 207.503 137.818 168.393 1.00 84.58  ? 9   LYS B O   1 
ATOM 923  C CB  . LYS B 1 10  ? 205.557 135.862 166.576 1.00 84.58  ? 9   LYS B CB  1 
ATOM 924  C CG  . LYS B 1 10  ? 204.326 134.987 166.490 1.00 84.58  ? 9   LYS B CG  1 
ATOM 925  C CD  . LYS B 1 10  ? 204.393 134.043 165.308 1.00 84.58  ? 9   LYS B CD  1 
ATOM 926  C CE  . LYS B 1 10  ? 203.156 133.177 165.258 1.00 84.58  ? 9   LYS B CE  1 
ATOM 927  N NZ  . LYS B 1 10  ? 202.794 132.685 166.618 1.00 84.58  ? 9   LYS B NZ  1 
ATOM 928  N N   . GLY B 1 11  ? 206.671 138.771 166.546 1.00 82.67  ? 10  GLY B N   1 
ATOM 929  C CA  . GLY B 1 11  ? 207.745 139.736 166.440 1.00 82.67  ? 10  GLY B CA  1 
ATOM 930  C C   . GLY B 1 11  ? 207.741 140.761 167.553 1.00 82.67  ? 10  GLY B C   1 
ATOM 931  O O   . GLY B 1 11  ? 207.112 140.557 168.594 1.00 82.67  ? 10  GLY B O   1 
ATOM 932  N N   . ASP B 1 12  ? 208.432 141.872 167.349 1.00 85.00  ? 11  ASP B N   1 
ATOM 933  C CA  . ASP B 1 12  ? 208.619 142.859 168.401 1.00 85.00  ? 11  ASP B CA  1 
ATOM 934  C C   . ASP B 1 12  ? 207.660 144.032 168.243 1.00 85.00  ? 11  ASP B C   1 
ATOM 935  O O   . ASP B 1 12  ? 207.161 144.319 167.153 1.00 85.00  ? 11  ASP B O   1 
ATOM 936  C CB  . ASP B 1 12  ? 210.057 143.369 168.402 1.00 85.00  ? 11  ASP B CB  1 
ATOM 937  C CG  . ASP B 1 12  ? 210.500 143.827 167.044 1.00 85.00  ? 11  ASP B CG  1 
ATOM 938  O OD1 . ASP B 1 12  ? 209.930 144.819 166.545 1.00 85.00  ? 11  ASP B OD1 1 
ATOM 939  O OD2 . ASP B 1 12  ? 211.412 143.197 166.473 1.00 85.00  ? 11  ASP B OD2 1 
ATOM 940  N N   . GLY B 1 13  ? 207.418 144.719 169.356 1.00 81.46  ? 12  GLY B N   1 
ATOM 941  C CA  . GLY B 1 13  ? 206.612 145.915 169.353 1.00 81.46  ? 12  GLY B CA  1 
ATOM 942  C C   . GLY B 1 13  ? 205.483 145.855 170.356 1.00 81.46  ? 12  GLY B C   1 
ATOM 943  O O   . GLY B 1 13  ? 204.867 144.809 170.568 1.00 81.46  ? 12  GLY B O   1 
ATOM 944  N N   . PRO B 1 14  ? 205.196 146.975 171.003 1.00 74.30  ? 13  PRO B N   1 
ATOM 945  C CA  . PRO B 1 14  ? 204.038 147.042 171.892 1.00 74.30  ? 13  PRO B CA  1 
ATOM 946  C C   . PRO B 1 14  ? 202.755 147.289 171.109 1.00 74.30  ? 13  PRO B C   1 
ATOM 947  O O   . PRO B 1 14  ? 202.767 147.738 169.963 1.00 74.30  ? 13  PRO B O   1 
ATOM 948  C CB  . PRO B 1 14  ? 204.376 148.221 172.802 1.00 74.30  ? 13  PRO B CB  1 
ATOM 949  C CG  . PRO B 1 14  ? 205.187 149.101 171.938 1.00 74.30  ? 13  PRO B CG  1 
ATOM 950  C CD  . PRO B 1 14  ? 205.983 148.215 171.036 1.00 74.30  ? 13  PRO B CD  1 
ATOM 951  N N   . VAL B 1 15  ? 201.632 146.995 171.760 1.00 66.63  ? 14  VAL B N   1 
ATOM 952  C CA  . VAL B 1 15  ? 200.355 146.932 171.060 1.00 66.63  ? 14  VAL B CA  1 
ATOM 953  C C   . VAL B 1 15  ? 199.419 148.050 171.488 1.00 66.63  ? 14  VAL B C   1 
ATOM 954  O O   . VAL B 1 15  ? 199.736 148.844 172.376 1.00 66.63  ? 14  VAL B O   1 
ATOM 955  C CB  . VAL B 1 15  ? 199.678 145.572 171.272 1.00 66.63  ? 14  VAL B CB  1 
ATOM 956  C CG1 . VAL B 1 15  ? 200.606 144.464 170.883 1.00 66.63  ? 14  VAL B CG1 1 
ATOM 957  C CG2 . VAL B 1 15  ? 199.270 145.435 172.691 1.00 66.63  ? 14  VAL B CG2 1 
ATOM 958  N N   . GLN B 1 16  ? 198.241 148.082 170.880 1.00 58.55  ? 15  GLN B N   1 
ATOM 959  C CA  . GLN B 1 16  ? 197.334 149.223 170.907 1.00 58.55  ? 15  GLN B CA  1 
ATOM 960  C C   . GLN B 1 16  ? 195.922 148.646 170.899 1.00 58.55  ? 15  GLN B C   1 
ATOM 961  O O   . GLN B 1 16  ? 195.691 147.514 171.334 1.00 58.55  ? 15  GLN B O   1 
ATOM 962  C CB  . GLN B 1 16  ? 197.645 150.167 169.733 1.00 58.55  ? 15  GLN B CB  1 
ATOM 963  C CG  . GLN B 1 16  ? 196.935 151.520 169.724 1.00 58.55  ? 15  GLN B CG  1 
ATOM 964  C CD  . GLN B 1 16  ? 197.479 152.514 170.719 1.00 58.55  ? 15  GLN B CD  1 
ATOM 965  O OE1 . GLN B 1 16  ? 197.767 152.177 171.860 1.00 58.55  ? 15  GLN B OE1 1 
ATOM 966  N NE2 . GLN B 1 16  ? 197.600 153.760 170.292 1.00 58.55  ? 15  GLN B NE2 1 
ATOM 967  N N   . GLY B 1 17  ? 194.945 149.434 170.478 1.00 54.42  ? 16  GLY B N   1 
ATOM 968  C CA  . GLY B 1 17  ? 193.581 148.956 170.417 1.00 54.42  ? 16  GLY B CA  1 
ATOM 969  C C   . GLY B 1 17  ? 193.334 147.785 169.490 1.00 54.42  ? 16  GLY B C   1 
ATOM 970  O O   . GLY B 1 17  ? 193.437 147.904 168.267 1.00 54.42  ? 16  GLY B O   1 
ATOM 971  N N   . ILE B 1 18  ? 193.019 146.638 170.083 1.00 55.76  ? 17  ILE B N   1 
ATOM 972  C CA  . ILE B 1 18  ? 192.454 145.490 169.388 1.00 55.76  ? 17  ILE B CA  1 
ATOM 973  C C   . ILE B 1 18  ? 191.175 145.124 170.120 1.00 55.76  ? 17  ILE B C   1 
ATOM 974  O O   . ILE B 1 18  ? 191.196 144.946 171.341 1.00 55.76  ? 17  ILE B O   1 
ATOM 975  C CB  . ILE B 1 18  ? 193.428 144.298 169.363 1.00 55.76  ? 17  ILE B CB  1 
ATOM 976  C CG1 . ILE B 1 18  ? 194.861 144.769 169.154 1.00 55.76  ? 17  ILE B CG1 1 
ATOM 977  C CG2 . ILE B 1 18  ? 193.058 143.328 168.268 1.00 55.76  ? 17  ILE B CG2 1 
ATOM 978  C CD1 . ILE B 1 18  ? 195.116 145.284 167.781 1.00 55.76  ? 17  ILE B CD1 1 
ATOM 979  N N   . ILE B 1 19  ? 190.059 145.031 169.396 1.00 52.25  ? 18  ILE B N   1 
ATOM 980  C CA  . ILE B 1 19  ? 188.775 144.852 170.063 1.00 52.25  ? 18  ILE B CA  1 
ATOM 981  C C   . ILE B 1 19  ? 187.992 143.716 169.421 1.00 52.25  ? 18  ILE B C   1 
ATOM 982  O O   . ILE B 1 19  ? 188.075 143.496 168.209 1.00 52.25  ? 18  ILE B O   1 
ATOM 983  C CB  . ILE B 1 19  ? 187.909 146.130 170.023 1.00 52.25  ? 18  ILE B CB  1 
ATOM 984  C CG1 . ILE B 1 19  ? 188.724 147.392 170.280 1.00 52.25  ? 18  ILE B CG1 1 
ATOM 985  C CG2 . ILE B 1 19  ? 186.862 146.060 171.107 1.00 52.25  ? 18  ILE B CG2 1 
ATOM 986  C CD1 . ILE B 1 19  ? 189.140 148.109 169.019 1.00 52.25  ? 18  ILE B CD1 1 
ATOM 987  N N   . ASN B 1 20  ? 187.198 143.012 170.240 1.00 54.17  ? 19  ASN B N   1 
ATOM 988  C CA  . ASN B 1 20  ? 186.005 142.323 169.758 1.00 54.17  ? 19  ASN B CA  1 
ATOM 989  C C   . ASN B 1 20  ? 184.813 142.661 170.643 1.00 54.17  ? 19  ASN B C   1 
ATOM 990  O O   . ASN B 1 20  ? 184.959 142.970 171.826 1.00 54.17  ? 19  ASN B O   1 
ATOM 991  C CB  . ASN B 1 20  ? 186.125 140.805 169.693 1.00 54.17  ? 19  ASN B CB  1 
ATOM 992  C CG  . ASN B 1 20  ? 186.333 140.196 171.021 1.00 54.17  ? 19  ASN B CG  1 
ATOM 993  O OD1 . ASN B 1 20  ? 186.649 140.888 171.971 1.00 54.17  ? 19  ASN B OD1 1 
ATOM 994  N ND2 . ASN B 1 20  ? 186.056 138.909 171.131 1.00 54.17  ? 19  ASN B ND2 1 
ATOM 995  N N   . PHE B 1 21  ? 183.623 142.565 170.057 1.00 53.94  ? 20  PHE B N   1 
ATOM 996  C CA  . PHE B 1 21  ? 182.393 143.032 170.674 1.00 53.94  ? 20  PHE B CA  1 
ATOM 997  C C   . PHE B 1 21  ? 181.251 142.238 170.063 1.00 53.94  ? 20  PHE B C   1 
ATOM 998  O O   . PHE B 1 21  ? 181.306 141.874 168.889 1.00 53.94  ? 20  PHE B O   1 
ATOM 999  C CB  . PHE B 1 21  ? 182.261 144.525 170.419 1.00 53.94  ? 20  PHE B CB  1 
ATOM 1000 C CG  . PHE B 1 21  ? 181.334 145.254 171.338 1.00 53.94  ? 20  PHE B CG  1 
ATOM 1001 C CD1 . PHE B 1 21  ? 180.014 145.429 171.007 1.00 53.94  ? 20  PHE B CD1 1 
ATOM 1002 C CD2 . PHE B 1 21  ? 181.807 145.846 172.475 1.00 53.94  ? 20  PHE B CD2 1 
ATOM 1003 C CE1 . PHE B 1 21  ? 179.188 146.126 171.810 1.00 53.94  ? 20  PHE B CE1 1 
ATOM 1004 C CE2 . PHE B 1 21  ? 180.971 146.549 173.278 1.00 53.94  ? 20  PHE B CE2 1 
ATOM 1005 C CZ  . PHE B 1 21  ? 179.661 146.682 172.949 1.00 53.94  ? 20  PHE B CZ  1 
ATOM 1006 N N   . GLU B 1 22  ? 180.212 141.970 170.851 1.00 58.86  ? 21  GLU B N   1 
ATOM 1007 C CA  . GLU B 1 22  ? 179.299 140.892 170.497 1.00 58.86  ? 21  GLU B CA  1 
ATOM 1008 C C   . GLU B 1 22  ? 177.925 141.356 170.031 1.00 58.86  ? 21  GLU B C   1 
ATOM 1009 O O   . GLU B 1 22  ? 177.605 141.193 168.851 1.00 58.86  ? 21  GLU B O   1 
ATOM 1010 C CB  . GLU B 1 22  ? 179.149 139.966 171.701 1.00 58.86  ? 21  GLU B CB  1 
ATOM 1011 C CG  . GLU B 1 22  ? 180.164 138.873 171.716 1.00 58.86  ? 21  GLU B CG  1 
ATOM 1012 C CD  . GLU B 1 22  ? 179.931 137.888 170.607 1.00 58.86  ? 21  GLU B CD  1 
ATOM 1013 O OE1 . GLU B 1 22  ? 180.703 137.910 169.633 1.00 58.86  ? 21  GLU B OE1 1 
ATOM 1014 O OE2 . GLU B 1 22  ? 178.968 137.100 170.705 1.00 58.86  ? 21  GLU B OE2 1 
ATOM 1015 N N   . GLN B 1 23  ? 177.130 141.989 170.890 1.00 52.64  ? 22  GLN B N   1 
ATOM 1016 C CA  . GLN B 1 23  ? 175.781 142.413 170.518 1.00 52.64  ? 22  GLN B CA  1 
ATOM 1017 C C   . GLN B 1 23  ? 175.000 141.274 169.858 1.00 52.64  ? 22  GLN B C   1 
ATOM 1018 O O   . GLN B 1 23  ? 174.751 141.263 168.658 1.00 52.64  ? 22  GLN B O   1 
ATOM 1019 C CB  . GLN B 1 23  ? 175.828 143.640 169.609 1.00 52.64  ? 22  GLN B CB  1 
ATOM 1020 C CG  . GLN B 1 23  ? 175.899 144.922 170.380 1.00 52.64  ? 22  GLN B CG  1 
ATOM 1021 C CD  . GLN B 1 23  ? 176.105 146.115 169.503 1.00 52.64  ? 22  GLN B CD  1 
ATOM 1022 O OE1 . GLN B 1 23  ? 176.077 146.015 168.285 1.00 52.64  ? 22  GLN B OE1 1 
ATOM 1023 N NE2 . GLN B 1 23  ? 176.320 147.261 170.119 1.00 52.64  ? 22  GLN B NE2 1 
ATOM 1024 N N   . LYS B 1 24  ? 174.681 140.278 170.668 1.00 56.13  ? 23  LYS B N   1 
ATOM 1025 C CA  . LYS B 1 24  ? 173.893 139.134 170.234 1.00 56.13  ? 23  LYS B CA  1 
ATOM 1026 C C   . LYS B 1 24  ? 172.436 139.349 170.629 1.00 56.13  ? 23  LYS B C   1 
ATOM 1027 O O   . LYS B 1 24  ? 172.118 139.444 171.818 1.00 56.13  ? 23  LYS B O   1 
ATOM 1028 C CB  . LYS B 1 24  ? 174.454 137.855 170.849 1.00 56.13  ? 23  LYS B CB  1 
ATOM 1029 C CG  . LYS B 1 24  ? 173.490 136.706 170.937 1.00 56.13  ? 23  LYS B CG  1 
ATOM 1030 C CD  . LYS B 1 24  ? 174.232 135.407 171.212 1.00 56.13  ? 23  LYS B CD  1 
ATOM 1031 C CE  . LYS B 1 24  ? 175.358 135.607 172.214 1.00 56.13  ? 23  LYS B CE  1 
ATOM 1032 N NZ  . LYS B 1 24  ? 176.122 134.352 172.443 1.00 56.13  ? 23  LYS B NZ  1 
ATOM 1033 N N   . GLU B 1 25  ? 171.555 139.425 169.631 1.00 60.25  ? 24  GLU B N   1 
ATOM 1034 C CA  . GLU B 1 25  ? 170.162 139.813 169.830 1.00 60.25  ? 24  GLU B CA  1 
ATOM 1035 C C   . GLU B 1 25  ? 169.230 138.858 169.105 1.00 60.25  ? 24  GLU B C   1 
ATOM 1036 O O   . GLU B 1 25  ? 169.345 138.678 167.890 1.00 60.25  ? 24  GLU B O   1 
ATOM 1037 C CB  . GLU B 1 25  ? 169.914 141.228 169.323 1.00 60.25  ? 24  GLU B CB  1 
ATOM 1038 C CG  . GLU B 1 25  ? 168.460 141.601 169.290 1.00 60.25  ? 24  GLU B CG  1 
ATOM 1039 C CD  . GLU B 1 25  ? 167.897 141.795 170.670 1.00 60.25  ? 24  GLU B CD  1 
ATOM 1040 O OE1 . GLU B 1 25  ? 168.119 142.870 171.257 1.00 60.25  ? 24  GLU B OE1 1 
ATOM 1041 O OE2 . GLU B 1 25  ? 167.235 140.870 171.174 1.00 60.25  ? 24  GLU B OE2 1 
ATOM 1042 N N   . SER B 1 26  ? 168.287 138.281 169.842 1.00 63.44  ? 25  SER B N   1 
ATOM 1043 C CA  . SER B 1 26  ? 167.352 137.300 169.306 1.00 63.44  ? 25  SER B CA  1 
ATOM 1044 C C   . SER B 1 26  ? 165.936 137.713 169.657 1.00 63.44  ? 25  SER B C   1 
ATOM 1045 O O   . SER B 1 26  ? 165.564 137.724 170.835 1.00 63.44  ? 25  SER B O   1 
ATOM 1046 C CB  . SER B 1 26  ? 167.636 135.907 169.859 1.00 63.44  ? 25  SER B CB  1 
ATOM 1047 O OG  . SER B 1 26  ? 167.432 135.886 171.256 1.00 63.44  ? 25  SER B OG  1 
ATOM 1048 N N   . ASN B 1 27  ? 165.144 138.021 168.636 1.00 66.45  ? 26  ASN B N   1 
ATOM 1049 C CA  . ASN B 1 27  ? 163.736 138.337 168.815 1.00 66.45  ? 26  ASN B CA  1 
ATOM 1050 C C   . ASN B 1 27  ? 162.947 137.055 169.003 1.00 66.45  ? 26  ASN B C   1 
ATOM 1051 O O   . ASN B 1 27  ? 163.518 136.001 169.292 1.00 66.45  ? 26  ASN B O   1 
ATOM 1052 C CB  . ASN B 1 27  ? 163.196 139.108 167.618 1.00 66.45  ? 26  ASN B CB  1 
ATOM 1053 C CG  . ASN B 1 27  ? 163.798 140.481 167.496 1.00 66.45  ? 26  ASN B CG  1 
ATOM 1054 O OD1 . ASN B 1 27  ? 164.137 141.113 168.491 1.00 66.45  ? 26  ASN B OD1 1 
ATOM 1055 N ND2 . ASN B 1 27  ? 163.931 140.956 166.267 1.00 66.45  ? 26  ASN B ND2 1 
ATOM 1056 N N   . GLY B 1 28  ? 161.634 137.140 168.888 1.00 69.54  ? 27  GLY B N   1 
ATOM 1057 C CA  . GLY B 1 28  ? 160.802 135.967 168.904 1.00 69.54  ? 27  GLY B CA  1 
ATOM 1058 C C   . GLY B 1 28  ? 159.558 136.202 168.084 1.00 69.54  ? 27  GLY B C   1 
ATOM 1059 O O   . GLY B 1 28  ? 159.584 136.857 167.037 1.00 69.54  ? 27  GLY B O   1 
ATOM 1060 N N   . PRO B 1 29  ? 158.442 135.634 168.530 1.00 67.30  ? 28  PRO B N   1 
ATOM 1061 C CA  . PRO B 1 29  ? 157.134 136.074 168.042 1.00 67.30  ? 28  PRO B CA  1 
ATOM 1062 C C   . PRO B 1 29  ? 156.561 137.144 168.957 1.00 67.30  ? 28  PRO B C   1 
ATOM 1063 O O   . PRO B 1 29  ? 156.779 137.136 170.166 1.00 67.30  ? 28  PRO B O   1 
ATOM 1064 C CB  . PRO B 1 29  ? 156.315 134.782 168.088 1.00 67.30  ? 28  PRO B CB  1 
ATOM 1065 C CG  . PRO B 1 29  ? 156.922 134.008 169.215 1.00 67.30  ? 28  PRO B CG  1 
ATOM 1066 C CD  . PRO B 1 29  ? 158.358 134.397 169.323 1.00 67.30  ? 28  PRO B CD  1 
ATOM 1067 N N   . VAL B 1 30  ? 155.838 138.104 168.381 1.00 63.47  ? 29  VAL B N   1 
ATOM 1068 C CA  . VAL B 1 30  ? 155.304 139.232 169.146 1.00 63.47  ? 29  VAL B CA  1 
ATOM 1069 C C   . VAL B 1 30  ? 153.773 139.204 169.225 1.00 63.47  ? 29  VAL B C   1 
ATOM 1070 O O   . VAL B 1 30  ? 153.206 139.155 170.316 1.00 63.47  ? 29  VAL B O   1 
ATOM 1071 C CB  . VAL B 1 30  ? 155.826 140.584 168.607 1.00 63.47  ? 29  VAL B CB  1 
ATOM 1072 C CG1 . VAL B 1 30  ? 157.292 140.733 168.929 1.00 63.47  ? 29  VAL B CG1 1 
ATOM 1073 C CG2 . VAL B 1 30  ? 155.623 140.715 167.144 1.00 63.47  ? 29  VAL B CG2 1 
ATOM 1074 N N   . LYS B 1 31  ? 153.091 139.240 168.077 1.00 60.03  ? 30  LYS B N   1 
ATOM 1075 C CA  . LYS B 1 31  ? 151.637 139.062 167.997 1.00 60.03  ? 30  LYS B CA  1 
ATOM 1076 C C   . LYS B 1 31  ? 150.880 140.123 168.807 1.00 60.03  ? 30  LYS B C   1 
ATOM 1077 O O   . LYS B 1 31  ? 150.315 139.861 169.867 1.00 60.03  ? 30  LYS B O   1 
ATOM 1078 C CB  . LYS B 1 31  ? 151.238 137.644 168.426 1.00 60.03  ? 30  LYS B CB  1 
ATOM 1079 C CG  . LYS B 1 31  ? 151.315 136.634 167.294 1.00 60.03  ? 30  LYS B CG  1 
ATOM 1080 C CD  . LYS B 1 31  ? 150.908 135.251 167.746 1.00 60.03  ? 30  LYS B CD  1 
ATOM 1081 C CE  . LYS B 1 31  ? 150.706 134.341 166.551 1.00 60.03  ? 30  LYS B CE  1 
ATOM 1082 N NZ  . LYS B 1 31  ? 149.837 133.174 166.862 1.00 60.03  ? 30  LYS B NZ  1 
ATOM 1083 N N   . VAL B 1 32  ? 150.920 141.348 168.294 1.00 52.32  ? 31  VAL B N   1 
ATOM 1084 C CA  . VAL B 1 32  ? 150.110 142.448 168.807 1.00 52.32  ? 31  VAL B CA  1 
ATOM 1085 C C   . VAL B 1 32  ? 149.007 142.756 167.802 1.00 52.32  ? 31  VAL B C   1 
ATOM 1086 O O   . VAL B 1 32  ? 149.228 142.686 166.590 1.00 52.32  ? 31  VAL B O   1 
ATOM 1087 C CB  . VAL B 1 32  ? 150.974 143.693 169.091 1.00 52.32  ? 31  VAL B CB  1 
ATOM 1088 C CG1 . VAL B 1 32  ? 151.781 144.061 167.875 1.00 52.32  ? 31  VAL B CG1 1 
ATOM 1089 C CG2 . VAL B 1 32  ? 150.116 144.867 169.491 1.00 52.32  ? 31  VAL B CG2 1 
ATOM 1090 N N   . TRP B 1 33  ? 147.813 143.079 168.299 1.00 50.12  ? 32  TRP B N   1 
ATOM 1091 C CA  . TRP B 1 33  ? 146.671 143.388 167.442 1.00 50.12  ? 32  TRP B CA  1 
ATOM 1092 C C   . TRP B 1 33  ? 146.328 144.861 167.553 1.00 50.12  ? 32  TRP B C   1 
ATOM 1093 O O   . TRP B 1 33  ? 145.956 145.339 168.628 1.00 50.12  ? 32  TRP B O   1 
ATOM 1094 C CB  . TRP B 1 33  ? 145.454 142.547 167.796 1.00 50.12  ? 32  TRP B CB  1 
ATOM 1095 C CG  . TRP B 1 33  ? 145.451 141.262 167.120 1.00 50.12  ? 32  TRP B CG  1 
ATOM 1096 C CD1 . TRP B 1 33  ? 144.859 140.966 165.942 1.00 50.12  ? 32  TRP B CD1 1 
ATOM 1097 C CD2 . TRP B 1 33  ? 146.076 140.070 167.572 1.00 50.12  ? 32  TRP B CD2 1 
ATOM 1098 N NE1 . TRP B 1 33  ? 145.072 139.654 165.628 1.00 50.12  ? 32  TRP B NE1 1 
ATOM 1099 C CE2 . TRP B 1 33  ? 145.825 139.083 166.618 1.00 50.12  ? 32  TRP B CE2 1 
ATOM 1100 C CE3 . TRP B 1 33  ? 146.836 139.744 168.692 1.00 50.12  ? 32  TRP B CE3 1 
ATOM 1101 C CZ2 . TRP B 1 33  ? 146.295 137.795 166.749 1.00 50.12  ? 32  TRP B CZ2 1 
ATOM 1102 C CZ3 . TRP B 1 33  ? 147.299 138.473 168.820 1.00 50.12  ? 32  TRP B CZ3 1 
ATOM 1103 C CH2 . TRP B 1 33  ? 147.032 137.510 167.856 1.00 50.12  ? 32  TRP B CH2 1 
ATOM 1104 N N   . GLY B 1 34  ? 146.419 145.559 166.432 1.00 50.35  ? 33  GLY B N   1 
ATOM 1105 C CA  . GLY B 1 34  ? 146.207 146.985 166.409 1.00 50.35  ? 33  GLY B CA  1 
ATOM 1106 C C   . GLY B 1 34  ? 147.211 147.688 165.526 1.00 50.35  ? 33  GLY B C   1 
ATOM 1107 O O   . GLY B 1 34  ? 147.327 147.383 164.339 1.00 50.35  ? 33  GLY B O   1 
ATOM 1108 N N   . SER B 1 35  ? 147.947 148.634 166.091 1.00 49.86  ? 34  SER B N   1 
ATOM 1109 C CA  . SER B 1 35  ? 148.908 149.375 165.293 1.00 49.86  ? 34  SER B CA  1 
ATOM 1110 C C   . SER B 1 35  ? 150.114 149.698 166.151 1.00 49.86  ? 34  SER B C   1 
ATOM 1111 O O   . SER B 1 35  ? 150.008 149.796 167.375 1.00 49.86  ? 34  SER B O   1 
ATOM 1112 C CB  . SER B 1 35  ? 148.298 150.660 164.732 1.00 49.86  ? 34  SER B CB  1 
ATOM 1113 O OG  . SER B 1 35  ? 148.297 151.678 165.711 1.00 49.86  ? 34  SER B OG  1 
ATOM 1114 N N   . ILE B 1 36  ? 151.260 149.836 165.504 1.00 46.94  ? 35  ILE B N   1 
ATOM 1115 C CA  . ILE B 1 36  ? 152.456 150.366 166.134 1.00 46.94  ? 35  ILE B CA  1 
ATOM 1116 C C   . ILE B 1 36  ? 152.954 151.493 165.251 1.00 46.94  ? 35  ILE B C   1 
ATOM 1117 O O   . ILE B 1 36  ? 152.938 151.372 164.023 1.00 46.94  ? 35  ILE B O   1 
ATOM 1118 C CB  . ILE B 1 36  ? 153.532 149.284 166.321 1.00 46.94  ? 35  ILE B CB  1 
ATOM 1119 C CG1 . ILE B 1 36  ? 152.897 147.962 166.721 1.00 46.94  ? 35  ILE B CG1 1 
ATOM 1120 C CG2 . ILE B 1 36  ? 154.489 149.675 167.413 1.00 46.94  ? 35  ILE B CG2 1 
ATOM 1121 C CD1 . ILE B 1 36  ? 153.862 146.826 166.749 1.00 46.94  ? 35  ILE B CD1 1 
ATOM 1122 N N   . LYS B 1 37  ? 153.357 152.597 165.861 1.00 46.42  ? 36  LYS B N   1 
ATOM 1123 C CA  . LYS B 1 37  ? 153.895 153.712 165.100 1.00 46.42  ? 36  LYS B CA  1 
ATOM 1124 C C   . LYS B 1 37  ? 155.129 154.247 165.795 1.00 46.42  ? 36  LYS B C   1 
ATOM 1125 O O   . LYS B 1 37  ? 155.276 154.128 167.012 1.00 46.42  ? 36  LYS B O   1 
ATOM 1126 C CB  . LYS B 1 37  ? 152.879 154.834 164.927 1.00 46.42  ? 36  LYS B CB  1 
ATOM 1127 C CG  . LYS B 1 37  ? 152.433 155.452 166.218 1.00 46.42  ? 36  LYS B CG  1 
ATOM 1128 C CD  . LYS B 1 37  ? 151.282 156.394 165.990 1.00 46.42  ? 36  LYS B CD  1 
ATOM 1129 C CE  . LYS B 1 37  ? 151.605 157.396 164.915 1.00 46.42  ? 36  LYS B CE  1 
ATOM 1130 N NZ  . LYS B 1 37  ? 150.862 158.653 165.145 1.00 46.42  ? 36  LYS B NZ  1 
ATOM 1131 N N   . GLY B 1 38  ? 156.008 154.848 165.012 1.00 49.06  ? 37  GLY B N   1 
ATOM 1132 C CA  . GLY B 1 38  ? 157.270 155.275 165.557 1.00 49.06  ? 37  GLY B CA  1 
ATOM 1133 C C   . GLY B 1 38  ? 158.130 154.075 165.868 1.00 49.06  ? 37  GLY B C   1 
ATOM 1134 O O   . GLY B 1 38  ? 158.317 153.739 167.039 1.00 49.06  ? 37  GLY B O   1 
ATOM 1135 N N   . LEU B 1 39  ? 158.621 153.398 164.830 1.00 52.31  ? 38  LEU B N   1 
ATOM 1136 C CA  . LEU B 1 39  ? 159.391 152.167 164.981 1.00 52.31  ? 38  LEU B CA  1 
ATOM 1137 C C   . LEU B 1 39  ? 160.656 152.238 164.137 1.00 52.31  ? 38  LEU B C   1 
ATOM 1138 O O   . LEU B 1 39  ? 160.589 152.204 162.906 1.00 52.31  ? 38  LEU B O   1 
ATOM 1139 C CB  . LEU B 1 39  ? 158.555 150.953 164.588 1.00 52.31  ? 38  LEU B CB  1 
ATOM 1140 C CG  . LEU B 1 39  ? 159.357 149.661 164.498 1.00 52.31  ? 38  LEU B CG  1 
ATOM 1141 C CD1 . LEU B 1 39  ? 159.959 149.351 165.849 1.00 52.31  ? 38  LEU B CD1 1 
ATOM 1142 C CD2 . LEU B 1 39  ? 158.483 148.534 164.024 1.00 52.31  ? 38  LEU B CD2 1 
ATOM 1143 N N   . THR B 1 40  ? 161.810 152.283 164.788 1.00 55.87  ? 39  THR B N   1 
ATOM 1144 C CA  . THR B 1 40  ? 163.087 152.401 164.098 1.00 55.87  ? 39  THR B CA  1 
ATOM 1145 C C   . THR B 1 40  ? 163.897 151.124 164.265 1.00 55.87  ? 39  THR B C   1 
ATOM 1146 O O   . THR B 1 40  ? 163.954 150.561 165.359 1.00 55.87  ? 39  THR B O   1 
ATOM 1147 C CB  . THR B 1 40  ? 163.866 153.593 164.639 1.00 55.87  ? 39  THR B CB  1 
ATOM 1148 O OG1 . THR B 1 40  ? 164.238 153.339 165.999 1.00 55.87  ? 39  THR B OG1 1 
ATOM 1149 C CG2 . THR B 1 40  ? 162.988 154.830 164.599 1.00 55.87  ? 39  THR B CG2 1 
ATOM 1150 N N   . GLU B 1 41  ? 164.517 150.663 163.176 1.00 59.34  ? 40  GLU B N   1 
ATOM 1151 C CA  . GLU B 1 41  ? 165.341 149.451 163.207 1.00 59.34  ? 40  GLU B CA  1 
ATOM 1152 C C   . GLU B 1 41  ? 166.637 149.714 162.450 1.00 59.34  ? 40  GLU B C   1 
ATOM 1153 O O   . GLU B 1 41  ? 166.676 149.627 161.223 1.00 59.34  ? 40  GLU B O   1 
ATOM 1154 C CB  . GLU B 1 41  ? 164.607 148.255 162.619 1.00 59.34  ? 40  GLU B CB  1 
ATOM 1155 C CG  . GLU B 1 41  ? 163.677 147.554 163.588 1.00 59.34  ? 40  GLU B CG  1 
ATOM 1156 C CD  . GLU B 1 41  ? 164.405 146.651 164.549 1.00 59.34  ? 40  GLU B CD  1 
ATOM 1157 O OE1 . GLU B 1 41  ? 165.648 146.717 164.608 1.00 59.34  ? 40  GLU B OE1 1 
ATOM 1158 O OE2 . GLU B 1 41  ? 163.729 145.869 165.251 1.00 59.34  ? 40  GLU B OE2 1 
ATOM 1159 N N   . GLY B 1 42  ? 167.693 150.003 163.180 1.00 59.43  ? 41  GLY B N   1 
ATOM 1160 C CA  . GLY B 1 42  ? 168.980 150.287 162.572 1.00 59.43  ? 41  GLY B CA  1 
ATOM 1161 C C   . GLY B 1 42  ? 170.087 149.483 163.211 1.00 59.43  ? 41  GLY B C   1 
ATOM 1162 O O   . GLY B 1 42  ? 170.094 149.263 164.419 1.00 59.43  ? 41  GLY B O   1 
ATOM 1163 N N   . LEU B 1 43  ? 171.021 149.041 162.380 1.00 55.24  ? 42  LEU B N   1 
ATOM 1164 C CA  . LEU B 1 43  ? 172.145 148.242 162.860 1.00 55.24  ? 42  LEU B CA  1 
ATOM 1165 C C   . LEU B 1 43  ? 173.359 148.614 162.006 1.00 55.24  ? 42  LEU B C   1 
ATOM 1166 O O   . LEU B 1 43  ? 173.578 148.037 160.945 1.00 55.24  ? 42  LEU B O   1 
ATOM 1167 C CB  . LEU B 1 43  ? 171.784 146.767 162.772 1.00 55.24  ? 42  LEU B CB  1 
ATOM 1168 C CG  . LEU B 1 43  ? 172.684 145.563 162.989 1.00 55.24  ? 42  LEU B CG  1 
ATOM 1169 C CD1 . LEU B 1 43  ? 172.938 145.341 164.423 1.00 55.24  ? 42  LEU B CD1 1 
ATOM 1170 C CD2 . LEU B 1 43  ? 171.982 144.357 162.442 1.00 55.24  ? 42  LEU B CD2 1 
ATOM 1171 N N   . HIS B 1 44  ? 174.098 149.631 162.446 1.00 55.10  ? 43  HIS B N   1 
ATOM 1172 C CA  . HIS B 1 44  ? 175.381 149.960 161.825 1.00 55.10  ? 43  HIS B CA  1 
ATOM 1173 C C   . HIS B 1 44  ? 176.170 150.894 162.729 1.00 55.10  ? 43  HIS B C   1 
ATOM 1174 O O   . HIS B 1 44  ? 175.789 152.060 162.870 1.00 55.10  ? 43  HIS B O   1 
ATOM 1175 C CB  . HIS B 1 44  ? 175.173 150.603 160.472 1.00 55.10  ? 43  HIS B CB  1 
ATOM 1176 C CG  . HIS B 1 44  ? 174.127 151.673 160.442 1.00 55.10  ? 43  HIS B CG  1 
ATOM 1177 N ND1 . HIS B 1 44  ? 174.106 152.723 161.332 1.00 55.10  ? 43  HIS B ND1 1 
ATOM 1178 C CD2 . HIS B 1 44  ? 173.096 151.883 159.592 1.00 55.10  ? 43  HIS B CD2 1 
ATOM 1179 C CE1 . HIS B 1 44  ? 173.084 153.512 161.055 1.00 55.10  ? 43  HIS B CE1 1 
ATOM 1180 N NE2 . HIS B 1 44  ? 172.456 153.026 160.001 1.00 55.10  ? 43  HIS B NE2 1 
ATOM 1181 N N   . GLY B 1 45  ? 177.252 150.410 163.340 1.00 53.55  ? 44  GLY B N   1 
ATOM 1182 C CA  . GLY B 1 45  ? 178.119 151.344 164.038 1.00 53.55  ? 44  GLY B CA  1 
ATOM 1183 C C   . GLY B 1 45  ? 179.604 151.142 163.833 1.00 53.55  ? 44  GLY B C   1 
ATOM 1184 O O   . GLY B 1 45  ? 180.158 150.159 164.329 1.00 53.55  ? 44  GLY B O   1 
ATOM 1185 N N   . PHE B 1 46  ? 180.269 152.076 163.136 1.00 50.11  ? 45  PHE B N   1 
ATOM 1186 C CA  . PHE B 1 46  ? 181.729 152.041 163.010 1.00 50.11  ? 45  PHE B CA  1 
ATOM 1187 C C   . PHE B 1 46  ? 182.234 153.413 162.563 1.00 50.11  ? 45  PHE B C   1 
ATOM 1188 O O   . PHE B 1 46  ? 182.235 153.694 161.363 1.00 50.11  ? 45  PHE B O   1 
ATOM 1189 C CB  . PHE B 1 46  ? 182.147 150.969 162.022 1.00 50.11  ? 45  PHE B CB  1 
ATOM 1190 C CG  . PHE B 1 46  ? 183.594 150.618 162.091 1.00 50.11  ? 45  PHE B CG  1 
ATOM 1191 C CD1 . PHE B 1 46  ? 184.044 149.687 162.990 1.00 50.11  ? 45  PHE B CD1 1 
ATOM 1192 C CD2 . PHE B 1 46  ? 184.501 151.217 161.250 1.00 50.11  ? 45  PHE B CD2 1 
ATOM 1193 C CE1 . PHE B 1 46  ? 185.354 149.368 163.043 1.00 50.11  ? 45  PHE B CE1 1 
ATOM 1194 C CE2 . PHE B 1 46  ? 185.815 150.896 161.311 1.00 50.11  ? 45  PHE B CE2 1 
ATOM 1195 C CZ  . PHE B 1 46  ? 186.240 149.975 162.206 1.00 50.11  ? 45  PHE B CZ  1 
ATOM 1196 N N   . HIS B 1 47  ? 182.738 154.215 163.500 1.00 51.38  ? 46  HIS B N   1 
ATOM 1197 C CA  . HIS B 1 47  ? 183.276 155.527 163.147 1.00 51.38  ? 46  HIS B CA  1 
ATOM 1198 C C   . HIS B 1 47  ? 184.556 155.788 163.921 1.00 51.38  ? 46  HIS B C   1 
ATOM 1199 O O   . HIS B 1 47  ? 184.557 155.782 165.153 1.00 51.38  ? 46  HIS B O   1 
ATOM 1200 C CB  . HIS B 1 47  ? 182.247 156.622 163.389 1.00 51.38  ? 46  HIS B CB  1 
ATOM 1201 C CG  . HIS B 1 47  ? 180.984 156.418 162.616 1.00 51.38  ? 46  HIS B CG  1 
ATOM 1202 N ND1 . HIS B 1 47  ? 179.738 156.423 163.203 1.00 51.38  ? 46  HIS B ND1 1 
ATOM 1203 C CD2 . HIS B 1 47  ? 180.778 156.166 161.303 1.00 51.38  ? 46  HIS B CD2 1 
ATOM 1204 C CE1 . HIS B 1 47  ? 178.819 156.200 162.281 1.00 51.38  ? 46  HIS B CE1 1 
ATOM 1205 N NE2 . HIS B 1 47  ? 179.424 156.041 161.119 1.00 51.38  ? 46  HIS B NE2 1 
ATOM 1206 N N   . VAL B 1 48  ? 185.642 155.985 163.176 1.00 47.70  ? 47  VAL B N   1 
ATOM 1207 C CA  . VAL B 1 48  ? 187.016 155.919 163.661 1.00 47.70  ? 47  VAL B CA  1 
ATOM 1208 C C   . VAL B 1 48  ? 187.837 157.140 163.261 1.00 47.70  ? 47  VAL B C   1 
ATOM 1209 O O   . VAL B 1 48  ? 188.867 156.988 162.604 1.00 47.70  ? 47  VAL B O   1 
ATOM 1210 C CB  . VAL B 1 48  ? 187.703 154.627 163.197 1.00 47.70  ? 47  VAL B CB  1 
ATOM 1211 C CG1 . VAL B 1 48  ? 188.968 154.404 163.981 1.00 47.70  ? 47  VAL B CG1 1 
ATOM 1212 C CG2 . VAL B 1 48  ? 186.792 153.460 163.400 1.00 47.70  ? 47  VAL B CG2 1 
ATOM 1213 N N   . HIS B 1 49  ? 187.353 158.347 163.536 1.00 48.52  ? 48  HIS B N   1 
ATOM 1214 C CA  . HIS B 1 49  ? 187.925 159.584 162.997 1.00 48.52  ? 48  HIS B CA  1 
ATOM 1215 C C   . HIS B 1 49  ? 189.423 159.587 162.723 1.00 48.52  ? 48  HIS B C   1 
ATOM 1216 O O   . HIS B 1 49  ? 189.850 160.039 161.658 1.00 48.52  ? 48  HIS B O   1 
ATOM 1217 C CB  . HIS B 1 49  ? 187.655 160.741 163.953 1.00 48.52  ? 48  HIS B CB  1 
ATOM 1218 C CG  . HIS B 1 49  ? 186.220 161.135 164.027 1.00 48.52  ? 48  HIS B CG  1 
ATOM 1219 N ND1 . HIS B 1 49  ? 185.675 161.742 165.136 1.00 48.52  ? 48  HIS B ND1 1 
ATOM 1220 C CD2 . HIS B 1 49  ? 185.213 160.997 163.135 1.00 48.52  ? 48  HIS B CD2 1 
ATOM 1221 C CE1 . HIS B 1 49  ? 184.391 161.963 164.922 1.00 48.52  ? 48  HIS B CE1 1 
ATOM 1222 N NE2 . HIS B 1 49  ? 184.087 161.518 163.717 1.00 48.52  ? 48  HIS B NE2 1 
ATOM 1223 N N   . GLU B 1 50  ? 190.233 159.098 163.654 1.00 51.47  ? 49  GLU B N   1 
ATOM 1224 C CA  . GLU B 1 50  ? 191.676 159.155 163.465 1.00 51.47  ? 49  GLU B CA  1 
ATOM 1225 C C   . GLU B 1 50  ? 192.355 158.079 164.289 1.00 51.47  ? 49  GLU B C   1 
ATOM 1226 O O   . GLU B 1 50  ? 192.050 157.922 165.472 1.00 51.47  ? 49  GLU B O   1 
ATOM 1227 C CB  . GLU B 1 50  ? 192.213 160.525 163.860 1.00 51.47  ? 49  GLU B CB  1 
ATOM 1228 C CG  . GLU B 1 50  ? 193.572 160.841 163.316 1.00 51.47  ? 49  GLU B CG  1 
ATOM 1229 C CD  . GLU B 1 50  ? 193.504 161.661 162.056 1.00 51.47  ? 49  GLU B CD  1 
ATOM 1230 O OE1 . GLU B 1 50  ? 192.454 162.288 161.811 1.00 51.47  ? 49  GLU B OE1 1 
ATOM 1231 O OE2 . GLU B 1 50  ? 194.511 161.700 161.324 1.00 51.47  ? 49  GLU B OE2 1 
ATOM 1232 N N   . PHE B 1 51  ? 193.289 157.358 163.670 1.00 51.37  ? 50  PHE B N   1 
ATOM 1233 C CA  . PHE B 1 51  ? 193.983 156.264 164.336 1.00 51.37  ? 50  PHE B CA  1 
ATOM 1234 C C   . PHE B 1 51  ? 195.198 156.700 165.131 1.00 51.37  ? 50  PHE B C   1 
ATOM 1235 O O   . PHE B 1 51  ? 195.686 155.920 165.948 1.00 51.37  ? 50  PHE B O   1 
ATOM 1236 C CB  . PHE B 1 51  ? 194.433 155.228 163.323 1.00 51.37  ? 50  PHE B CB  1 
ATOM 1237 C CG  . PHE B 1 51  ? 193.411 154.196 163.019 1.00 51.37  ? 50  PHE B CG  1 
ATOM 1238 C CD1 . PHE B 1 51  ? 193.303 153.074 163.799 1.00 51.37  ? 50  PHE B CD1 1 
ATOM 1239 C CD2 . PHE B 1 51  ? 192.576 154.333 161.936 1.00 51.37  ? 50  PHE B CD2 1 
ATOM 1240 C CE1 . PHE B 1 51  ? 192.374 152.120 163.519 1.00 51.37  ? 50  PHE B CE1 1 
ATOM 1241 C CE2 . PHE B 1 51  ? 191.647 153.374 161.650 1.00 51.37  ? 50  PHE B CE2 1 
ATOM 1242 C CZ  . PHE B 1 51  ? 191.548 152.267 162.445 1.00 51.37  ? 50  PHE B CZ  1 
ATOM 1243 N N   . GLY B 1 52  ? 195.713 157.897 164.910 1.00 56.95  ? 51  GLY B N   1 
ATOM 1244 C CA  . GLY B 1 52  ? 196.921 158.343 165.581 1.00 56.95  ? 51  GLY B CA  1 
ATOM 1245 C C   . GLY B 1 52  ? 198.138 158.182 164.684 1.00 56.95  ? 51  GLY B C   1 
ATOM 1246 O O   . GLY B 1 52  ? 198.157 158.683 163.564 1.00 56.95  ? 51  GLY B O   1 
ATOM 1247 N N   . ASP B 1 53  ? 199.150 157.471 165.180 1.00 61.98  ? 52  ASP B N   1 
ATOM 1248 C CA  . ASP B 1 53  ? 200.351 157.241 164.386 1.00 61.98  ? 52  ASP B CA  1 
ATOM 1249 C C   . ASP B 1 53  ? 201.216 156.181 165.038 1.00 61.98  ? 52  ASP B C   1 
ATOM 1250 O O   . ASP B 1 53  ? 201.253 156.055 166.262 1.00 61.98  ? 52  ASP B O   1 
ATOM 1251 C CB  . ASP B 1 53  ? 201.160 158.522 164.215 1.00 61.98  ? 52  ASP B CB  1 
ATOM 1252 C CG  . ASP B 1 53  ? 201.259 159.299 165.483 1.00 61.98  ? 52  ASP B CG  1 
ATOM 1253 O OD1 . ASP B 1 53  ? 200.561 158.923 166.440 1.00 61.98  ? 52  ASP B OD1 1 
ATOM 1254 O OD2 . ASP B 1 53  ? 202.021 160.284 165.526 1.00 61.98  ? 52  ASP B OD2 1 
ATOM 1255 N N   . ASN B 1 54  ? 201.926 155.442 164.197 1.00 67.66  ? 53  ASN B N   1 
ATOM 1256 C CA  . ASN B 1 54  ? 202.905 154.453 164.619 1.00 67.66  ? 53  ASN B CA  1 
ATOM 1257 C C   . ASN B 1 54  ? 204.301 154.979 164.333 1.00 67.66  ? 53  ASN B C   1 
ATOM 1258 O O   . ASN B 1 54  ? 204.538 155.560 163.269 1.00 67.66  ? 53  ASN B O   1 
ATOM 1259 C CB  . ASN B 1 54  ? 202.698 153.137 163.879 1.00 67.66  ? 53  ASN B CB  1 
ATOM 1260 C CG  . ASN B 1 54  ? 201.673 152.279 164.521 1.00 67.66  ? 53  ASN B CG  1 
ATOM 1261 O OD1 . ASN B 1 54  ? 201.707 152.041 165.724 1.00 67.66  ? 53  ASN B OD1 1 
ATOM 1262 N ND2 . ASN B 1 54  ? 200.744 151.801 163.726 1.00 67.66  ? 53  ASN B ND2 1 
ATOM 1263 N N   . THR B 1 55  ? 205.226 154.750 165.259 1.00 69.82  ? 54  THR B N   1 
ATOM 1264 C CA  . THR B 1 55  ? 206.582 155.260 165.134 1.00 69.82  ? 54  THR B CA  1 
ATOM 1265 C C   . THR B 1 55  ? 207.557 154.108 164.969 1.00 69.82  ? 54  THR B C   1 
ATOM 1266 O O   . THR B 1 55  ? 207.545 153.166 165.765 1.00 69.82  ? 54  THR B O   1 
ATOM 1267 C CB  . THR B 1 55  ? 206.990 156.073 166.346 1.00 69.82  ? 54  THR B CB  1 
ATOM 1268 O OG1 . THR B 1 55  ? 207.204 155.175 167.428 1.00 69.82  ? 54  THR B OG1 1 
ATOM 1269 C CG2 . THR B 1 55  ? 205.896 157.039 166.726 1.00 69.82  ? 54  THR B CG2 1 
ATOM 1270 N N   . ALA B 1 56  ? 208.409 154.200 163.952 1.00 65.00  ? 55  ALA B N   1 
ATOM 1271 C CA  . ALA B 1 56  ? 209.505 153.257 163.759 1.00 65.00  ? 55  ALA B CA  1 
ATOM 1272 C C   . ALA B 1 56  ? 210.478 153.776 162.710 1.00 65.00  ? 55  ALA B C   1 
ATOM 1273 O O   . ALA B 1 56  ? 211.113 154.811 162.898 1.00 65.00  ? 55  ALA B O   1 
ATOM 1274 C CB  . ALA B 1 56  ? 208.981 151.898 163.360 1.00 65.00  ? 55  ALA B CB  1 
ATOM 1275 N N   . ASN B 1 87  ? 192.880 175.998 165.287 1.00 64.41  ? 86  ASN B N   1 
ATOM 1276 C CA  . ASN B 1 87  ? 192.407 177.266 164.755 1.00 64.41  ? 86  ASN B CA  1 
ATOM 1277 C C   . ASN B 1 87  ? 190.950 177.171 164.337 1.00 64.41  ? 86  ASN B C   1 
ATOM 1278 O O   . ASN B 1 87  ? 190.630 177.281 163.156 1.00 64.41  ? 86  ASN B O   1 
ATOM 1279 C CB  . ASN B 1 87  ? 193.263 177.698 163.568 1.00 64.41  ? 86  ASN B CB  1 
ATOM 1280 C CG  . ASN B 1 87  ? 193.244 179.191 163.358 1.00 64.41  ? 86  ASN B CG  1 
ATOM 1281 O OD1 . ASN B 1 87  ? 192.907 179.948 164.264 1.00 64.41  ? 86  ASN B OD1 1 
ATOM 1282 N ND2 . ASN B 1 87  ? 193.608 179.628 162.162 1.00 64.41  ? 86  ASN B ND2 1 
ATOM 1283 N N   . VAL B 1 88  ? 190.065 176.968 165.310 1.00 64.68  ? 87  VAL B N   1 
ATOM 1284 C CA  . VAL B 1 88  ? 188.640 176.789 165.053 1.00 64.68  ? 87  VAL B CA  1 
ATOM 1285 C C   . VAL B 1 88  ? 187.868 177.843 165.830 1.00 64.68  ? 87  VAL B C   1 
ATOM 1286 O O   . VAL B 1 88  ? 188.021 177.967 167.052 1.00 64.68  ? 87  VAL B O   1 
ATOM 1287 C CB  . VAL B 1 88  ? 188.165 175.363 165.386 1.00 64.68  ? 87  VAL B CB  1 
ATOM 1288 C CG1 . VAL B 1 88  ? 188.509 174.983 166.783 1.00 64.68  ? 87  VAL B CG1 1 
ATOM 1289 C CG2 . VAL B 1 88  ? 186.682 175.253 165.178 1.00 64.68  ? 87  VAL B CG2 1 
ATOM 1290 N N   . THR B 1 89  ? 187.050 178.607 165.112 1.00 66.76  ? 88  THR B N   1 
ATOM 1291 C CA  . THR B 1 89  ? 186.424 179.804 165.662 1.00 66.76  ? 88  THR B CA  1 
ATOM 1292 C C   . THR B 1 89  ? 185.053 180.005 165.033 1.00 66.76  ? 88  THR B C   1 
ATOM 1293 O O   . THR B 1 89  ? 184.941 180.263 163.831 1.00 66.76  ? 88  THR B O   1 
ATOM 1294 C CB  . THR B 1 89  ? 187.318 181.027 165.449 1.00 66.76  ? 88  THR B CB  1 
ATOM 1295 O OG1 . THR B 1 89  ? 186.624 182.212 165.854 1.00 66.76  ? 88  THR B OG1 1 
ATOM 1296 C CG2 . THR B 1 89  ? 187.796 181.141 164.009 1.00 66.76  ? 88  THR B CG2 1 
ATOM 1297 N N   . ALA B 1 90  ? 184.017 179.882 165.852 1.00 68.72  ? 89  ALA B N   1 
ATOM 1298 C CA  . ALA B 1 90  ? 182.657 180.211 165.461 1.00 68.72  ? 89  ALA B CA  1 
ATOM 1299 C C   . ALA B 1 90  ? 182.329 181.558 166.073 1.00 68.72  ? 89  ALA B C   1 
ATOM 1300 O O   . ALA B 1 90  ? 182.434 181.725 167.291 1.00 68.72  ? 89  ALA B O   1 
ATOM 1301 C CB  . ALA B 1 90  ? 181.678 179.148 165.940 1.00 68.72  ? 89  ALA B CB  1 
ATOM 1302 N N   . ASP B 1 91  ? 181.945 182.518 165.239 1.00 76.07  ? 90  ASP B N   1 
ATOM 1303 C CA  . ASP B 1 91  ? 182.020 183.903 165.685 1.00 76.07  ? 90  ASP B CA  1 
ATOM 1304 C C   . ASP B 1 91  ? 180.710 184.412 166.283 1.00 76.07  ? 90  ASP B C   1 
ATOM 1305 O O   . ASP B 1 91  ? 180.652 184.744 167.468 1.00 76.07  ? 90  ASP B O   1 
ATOM 1306 C CB  . ASP B 1 91  ? 182.471 184.791 164.522 1.00 76.07  ? 90  ASP B CB  1 
ATOM 1307 C CG  . ASP B 1 91  ? 182.304 186.258 164.820 1.00 76.07  ? 90  ASP B CG  1 
ATOM 1308 O OD1 . ASP B 1 91  ? 182.854 186.722 165.840 1.00 76.07  ? 90  ASP B OD1 1 
ATOM 1309 O OD2 . ASP B 1 91  ? 181.625 186.949 164.037 1.00 76.07  ? 90  ASP B OD2 1 
ATOM 1310 N N   . LYS B 1 92  ? 179.650 184.468 165.497 1.00 75.98  ? 91  LYS B N   1 
ATOM 1311 C CA  . LYS B 1 92  ? 178.384 184.971 166.003 1.00 75.98  ? 91  LYS B CA  1 
ATOM 1312 C C   . LYS B 1 92  ? 177.482 183.796 166.331 1.00 75.98  ? 91  LYS B C   1 
ATOM 1313 O O   . LYS B 1 92  ? 177.332 182.880 165.521 1.00 75.98  ? 91  LYS B O   1 
ATOM 1314 C CB  . LYS B 1 92  ? 177.719 185.903 164.998 1.00 75.98  ? 91  LYS B CB  1 
ATOM 1315 C CG  . LYS B 1 92  ? 178.513 187.160 164.749 1.00 75.98  ? 91  LYS B CG  1 
ATOM 1316 C CD  . LYS B 1 92  ? 179.036 187.741 166.049 1.00 75.98  ? 91  LYS B CD  1 
ATOM 1317 C CE  . LYS B 1 92  ? 179.842 189.006 165.804 1.00 75.98  ? 91  LYS B CE  1 
ATOM 1318 N NZ  . LYS B 1 92  ? 180.525 189.485 167.036 1.00 75.98  ? 91  LYS B NZ  1 
ATOM 1319 N N   . ASP B 1 93  ? 176.969 183.778 167.554 1.00 73.35  ? 92  ASP B N   1 
ATOM 1320 C CA  . ASP B 1 93  ? 175.966 182.814 167.982 1.00 73.35  ? 92  ASP B CA  1 
ATOM 1321 C C   . ASP B 1 93  ? 176.483 181.381 167.936 1.00 73.35  ? 92  ASP B C   1 
ATOM 1322 O O   . ASP B 1 93  ? 175.779 180.460 168.349 1.00 73.35  ? 92  ASP B O   1 
ATOM 1323 C CB  . ASP B 1 93  ? 174.716 182.935 167.118 1.00 73.35  ? 92  ASP B CB  1 
ATOM 1324 C CG  . ASP B 1 93  ? 174.097 184.309 167.183 1.00 73.35  ? 92  ASP B CG  1 
ATOM 1325 O OD1 . ASP B 1 93  ? 174.325 185.023 168.177 1.00 73.35  ? 92  ASP B OD1 1 
ATOM 1326 O OD2 . ASP B 1 93  ? 173.366 184.671 166.243 1.00 73.35  ? 92  ASP B OD2 1 
ATOM 1327 N N   . GLY B 1 94  ? 177.710 181.175 167.491 1.00 65.96  ? 93  GLY B N   1 
ATOM 1328 C CA  . GLY B 1 94  ? 178.127 179.856 167.074 1.00 65.96  ? 93  GLY B CA  1 
ATOM 1329 C C   . GLY B 1 94  ? 178.687 178.994 168.175 1.00 65.96  ? 93  GLY B C   1 
ATOM 1330 O O   . GLY B 1 94  ? 179.144 179.478 169.196 1.00 65.96  ? 93  GLY B O   1 
ATOM 1331 N N   . VAL B 1 95  ? 178.685 177.691 167.923 1.00 59.59  ? 94  VAL B N   1 
ATOM 1332 C CA  . VAL B 1 95  ? 179.058 176.705 168.919 1.00 59.59  ? 94  VAL B CA  1 
ATOM 1333 C C   . VAL B 1 95  ? 180.431 176.152 168.570 1.00 59.59  ? 94  VAL B C   1 
ATOM 1334 O O   . VAL B 1 95  ? 180.978 176.419 167.504 1.00 59.59  ? 94  VAL B O   1 
ATOM 1335 C CB  . VAL B 1 95  ? 178.022 175.579 169.012 1.00 59.59  ? 94  VAL B CB  1 
ATOM 1336 C CG1 . VAL B 1 95  ? 176.712 176.124 169.518 1.00 59.59  ? 94  VAL B CG1 1 
ATOM 1337 C CG2 . VAL B 1 95  ? 177.833 174.960 167.674 1.00 59.59  ? 94  VAL B CG2 1 
ATOM 1338 N N   . ALA B 1 96  ? 180.984 175.351 169.478 1.00 59.06  ? 95  ALA B N   1 
ATOM 1339 C CA  . ALA B 1 96  ? 182.328 174.814 169.287 1.00 59.06  ? 95  ALA B CA  1 
ATOM 1340 C C   . ALA B 1 96  ? 182.502 173.518 170.060 1.00 59.06  ? 95  ALA B C   1 
ATOM 1341 O O   . ALA B 1 96  ? 182.351 173.502 171.283 1.00 59.06  ? 95  ALA B O   1 
ATOM 1342 C CB  . ALA B 1 96  ? 183.380 175.829 169.725 1.00 59.06  ? 95  ALA B CB  1 
ATOM 1343 N N   . ASP B 1 97  ? 182.839 172.444 169.350 1.00 60.39  ? 96  ASP B N   1 
ATOM 1344 C CA  . ASP B 1 97  ? 183.331 171.207 169.954 1.00 60.39  ? 96  ASP B CA  1 
ATOM 1345 C C   . ASP B 1 97  ? 182.330 170.607 170.944 1.00 60.39  ? 96  ASP B C   1 
ATOM 1346 O O   . ASP B 1 97  ? 182.551 170.571 172.144 1.00 60.39  ? 96  ASP B O   1 
ATOM 1347 C CB  . ASP B 1 97  ? 184.691 171.432 170.611 1.00 60.39  ? 96  ASP B CB  1 
ATOM 1348 C CG  . ASP B 1 97  ? 185.823 170.927 169.758 1.00 60.39  ? 96  ASP B CG  1 
ATOM 1349 O OD1 . ASP B 1 97  ? 185.569 170.612 168.580 1.00 60.39  ? 96  ASP B OD1 1 
ATOM 1350 O OD2 . ASP B 1 97  ? 186.959 170.825 170.263 1.00 60.39  ? 96  ASP B OD2 1 
ATOM 1351 N N   . VAL B 1 98  ? 181.213 170.139 170.410 1.00 52.41  ? 97  VAL B N   1 
ATOM 1352 C CA  . VAL B 1 98  ? 180.259 169.378 171.201 1.00 52.41  ? 97  VAL B CA  1 
ATOM 1353 C C   . VAL B 1 98  ? 179.960 168.076 170.473 1.00 52.41  ? 97  VAL B C   1 
ATOM 1354 O O   . VAL B 1 98  ? 179.924 168.040 169.238 1.00 52.41  ? 97  VAL B O   1 
ATOM 1355 C CB  . VAL B 1 98  ? 178.980 170.194 171.475 1.00 52.41  ? 97  VAL B CB  1 
ATOM 1356 C CG1 . VAL B 1 98  ? 177.898 169.329 172.064 1.00 52.41  ? 97  VAL B CG1 1 
ATOM 1357 C CG2 . VAL B 1 98  ? 179.289 171.307 172.435 1.00 52.41  ? 97  VAL B CG2 1 
ATOM 1358 N N   . SER B 1 99  ? 179.768 167.001 171.236 1.00 49.50  ? 98  SER B N   1 
ATOM 1359 C CA  . SER B 1 99  ? 179.566 165.679 170.657 1.00 49.50  ? 98  SER B CA  1 
ATOM 1360 C C   . SER B 1 99  ? 178.703 164.846 171.589 1.00 49.50  ? 98  SER B C   1 
ATOM 1361 O O   . SER B 1 99  ? 179.083 164.622 172.736 1.00 49.50  ? 98  SER B O   1 
ATOM 1362 C CB  . SER B 1 99  ? 180.913 164.997 170.414 1.00 49.50  ? 98  SER B CB  1 
ATOM 1363 O OG  . SER B 1 99  ? 180.784 163.852 169.595 1.00 49.50  ? 98  SER B OG  1 
ATOM 1364 N N   . ILE B 1 100 ? 177.562 164.369 171.108 1.00 46.87  ? 99  ILE B N   1 
ATOM 1365 C CA  . ILE B 1 100 ? 176.620 163.624 171.935 1.00 46.87  ? 99  ILE B CA  1 
ATOM 1366 C C   . ILE B 1 100 ? 176.397 162.251 171.321 1.00 46.87  ? 99  ILE B C   1 
ATOM 1367 O O   . ILE B 1 100 ? 176.348 162.117 170.093 1.00 46.87  ? 99  ILE B O   1 
ATOM 1368 C CB  . ILE B 1 100 ? 175.278 164.375 172.080 1.00 46.87  ? 99  ILE B CB  1 
ATOM 1369 C CG1 . ILE B 1 100 ? 175.470 165.716 172.772 1.00 46.87  ? 99  ILE B CG1 1 
ATOM 1370 C CG2 . ILE B 1 100 ? 174.271 163.557 172.842 1.00 46.87  ? 99  ILE B CG2 1 
ATOM 1371 C CD1 . ILE B 1 100 ? 175.351 166.866 171.840 1.00 46.87  ? 99  ILE B CD1 1 
ATOM 1372 N N   . GLU B 1 101 ? 176.266 161.231 172.177 1.00 50.93  ? 100 GLU B N   1 
ATOM 1373 C CA  . GLU B 1 101 ? 175.820 159.903 171.769 1.00 50.93  ? 100 GLU B CA  1 
ATOM 1374 C C   . GLU B 1 101 ? 174.956 159.290 172.864 1.00 50.93  ? 100 GLU B C   1 
ATOM 1375 O O   . GLU B 1 101 ? 174.818 159.847 173.948 1.00 50.93  ? 100 GLU B O   1 
ATOM 1376 C CB  . GLU B 1 101 ? 176.996 158.985 171.439 1.00 50.93  ? 100 GLU B CB  1 
ATOM 1377 C CG  . GLU B 1 101 ? 177.846 159.463 170.289 1.00 50.93  ? 100 GLU B CG  1 
ATOM 1378 C CD  . GLU B 1 101 ? 179.137 158.714 170.195 1.00 50.93  ? 100 GLU B CD  1 
ATOM 1379 O OE1 . GLU B 1 101 ? 179.105 157.562 169.727 1.00 50.93  ? 100 GLU B OE1 1 
ATOM 1380 O OE2 . GLU B 1 101 ? 180.179 159.269 170.596 1.00 50.93  ? 100 GLU B OE2 1 
ATOM 1381 N N   . ASP B 1 102 ? 174.336 158.149 172.556 1.00 49.13  ? 101 ASP B N   1 
ATOM 1382 C CA  . ASP B 1 102 ? 173.567 157.353 173.522 1.00 49.13  ? 101 ASP B CA  1 
ATOM 1383 C C   . ASP B 1 102 ? 172.464 158.181 174.187 1.00 49.13  ? 101 ASP B C   1 
ATOM 1384 O O   . ASP B 1 102 ? 172.444 158.382 175.399 1.00 49.13  ? 101 ASP B O   1 
ATOM 1385 C CB  . ASP B 1 102 ? 174.495 156.736 174.572 1.00 49.13  ? 101 ASP B CB  1 
ATOM 1386 C CG  . ASP B 1 102 ? 173.972 155.424 175.124 1.00 49.13  ? 101 ASP B CG  1 
ATOM 1387 O OD1 . ASP B 1 102 ? 172.745 155.275 175.270 1.00 49.13  ? 101 ASP B OD1 1 
ATOM 1388 O OD2 . ASP B 1 102 ? 174.796 154.534 175.414 1.00 49.13  ? 101 ASP B OD2 1 
ATOM 1389 N N   . SER B 1 103 ? 171.531 158.646 173.363 1.00 45.36  ? 102 SER B N   1 
ATOM 1390 C CA  . SER B 1 103 ? 170.501 159.574 173.803 1.00 45.36  ? 102 SER B CA  1 
ATOM 1391 C C   . SER B 1 103 ? 169.215 159.316 173.042 1.00 45.36  ? 102 SER B C   1 
ATOM 1392 O O   . SER B 1 103 ? 169.210 159.324 171.811 1.00 45.36  ? 102 SER B O   1 
ATOM 1393 C CB  . SER B 1 103 ? 170.953 161.017 173.592 1.00 45.36  ? 102 SER B CB  1 
ATOM 1394 O OG  . SER B 1 103 ? 171.313 161.238 172.243 1.00 45.36  ? 102 SER B OG  1 
ATOM 1395 N N   . VAL B 1 104 ? 168.128 159.109 173.773 1.00 39.79  ? 103 VAL B N   1 
ATOM 1396 C CA  . VAL B 1 104 ? 166.828 158.799 173.195 1.00 39.79  ? 103 VAL B CA  1 
ATOM 1397 C C   . VAL B 1 104 ? 165.788 159.749 173.769 1.00 39.79  ? 103 VAL B C   1 
ATOM 1398 O O   . VAL B 1 104 ? 165.760 159.989 174.980 1.00 39.79  ? 103 VAL B O   1 
ATOM 1399 C CB  . VAL B 1 104 ? 166.439 157.330 173.444 1.00 39.79  ? 103 VAL B CB  1 
ATOM 1400 C CG1 . VAL B 1 104 ? 166.594 156.991 174.878 1.00 39.79  ? 103 VAL B CG1 1 
ATOM 1401 C CG2 . VAL B 1 104 ? 165.010 157.093 173.046 1.00 39.79  ? 103 VAL B CG2 1 
ATOM 1402 N N   . ILE B 1 105 ? 164.941 160.293 172.896 1.00 38.29  ? 104 ILE B N   1 
ATOM 1403 C CA  . ILE B 1 105 ? 163.888 161.230 173.270 1.00 38.29  ? 104 ILE B CA  1 
ATOM 1404 C C   . ILE B 1 105 ? 162.595 160.785 172.611 1.00 38.29  ? 104 ILE B C   1 
ATOM 1405 O O   . ILE B 1 105 ? 162.502 160.756 171.380 1.00 38.29  ? 104 ILE B O   1 
ATOM 1406 C CB  . ILE B 1 105 ? 164.226 162.666 172.851 1.00 38.29  ? 104 ILE B CB  1 
ATOM 1407 C CG1 . ILE B 1 105 ? 165.180 163.291 173.852 1.00 38.29  ? 104 ILE B CG1 1 
ATOM 1408 C CG2 . ILE B 1 105 ? 162.983 163.501 172.770 1.00 38.29  ? 104 ILE B CG2 1 
ATOM 1409 C CD1 . ILE B 1 105 ? 165.547 164.676 173.494 1.00 38.29  ? 104 ILE B CD1 1 
ATOM 1410 N N   . SER B 1 106 ? 161.597 160.457 173.420 1.00 40.15  ? 105 SER B N   1 
ATOM 1411 C CA  . SER B 1 106 ? 160.294 160.038 172.928 1.00 40.15  ? 105 SER B CA  1 
ATOM 1412 C C   . SER B 1 106 ? 159.231 160.974 173.481 1.00 40.15  ? 105 SER B C   1 
ATOM 1413 O O   . SER B 1 106 ? 159.059 161.069 174.702 1.00 40.15  ? 105 SER B O   1 
ATOM 1414 C CB  . SER B 1 106 ? 159.986 158.600 173.338 1.00 40.15  ? 105 SER B CB  1 
ATOM 1415 O OG  . SER B 1 106 ? 159.347 158.576 174.602 1.00 40.15  ? 105 SER B OG  1 
ATOM 1416 N N   . LEU B 1 107 ? 158.545 161.683 172.590 1.00 40.13  ? 106 LEU B N   1 
ATOM 1417 C CA  . LEU B 1 107 ? 157.433 162.546 172.970 1.00 40.13  ? 106 LEU B CA  1 
ATOM 1418 C C   . LEU B 1 107 ? 156.329 162.503 171.916 1.00 40.13  ? 106 LEU B C   1 
ATOM 1419 O O   . LEU B 1 107 ? 155.819 163.533 171.480 1.00 40.13  ? 106 LEU B O   1 
ATOM 1420 C CB  . LEU B 1 107 ? 157.932 163.965 173.235 1.00 40.13  ? 106 LEU B CB  1 
ATOM 1421 C CG  . LEU B 1 107 ? 158.403 164.909 172.132 1.00 40.13  ? 106 LEU B CG  1 
ATOM 1422 C CD1 . LEU B 1 107 ? 158.549 166.268 172.726 1.00 40.13  ? 106 LEU B CD1 1 
ATOM 1423 C CD2 . LEU B 1 107 ? 159.706 164.475 171.533 1.00 40.13  ? 106 LEU B CD2 1 
ATOM 1424 N N   . SER B 1 108 ? 155.949 161.303 171.476 1.00 44.59  ? 107 SER B N   1 
ATOM 1425 C CA  . SER B 1 108 ? 155.087 161.194 170.300 1.00 44.59  ? 107 SER B CA  1 
ATOM 1426 C C   . SER B 1 108 ? 153.757 161.916 170.509 1.00 44.59  ? 107 SER B C   1 
ATOM 1427 O O   . SER B 1 108 ? 153.458 162.900 169.827 1.00 44.59  ? 107 SER B O   1 
ATOM 1428 C CB  . SER B 1 108 ? 154.864 159.727 169.939 1.00 44.59  ? 107 SER B CB  1 
ATOM 1429 O OG  . SER B 1 108 ? 154.150 159.627 168.722 1.00 44.59  ? 107 SER B OG  1 
ATOM 1430 N N   . GLY B 1 109 ? 152.951 161.456 171.456 1.00 48.81  ? 108 GLY B N   1 
ATOM 1431 C CA  . GLY B 1 109 ? 151.723 162.172 171.748 1.00 48.81  ? 108 GLY B CA  1 
ATOM 1432 C C   . GLY B 1 109 ? 150.709 162.110 170.619 1.00 48.81  ? 108 GLY B C   1 
ATOM 1433 O O   . GLY B 1 109 ? 150.891 161.423 169.623 1.00 48.81  ? 108 GLY B O   1 
ATOM 1434 N N   . ASP B 1 110 ? 149.617 162.856 170.801 1.00 49.90  ? 109 ASP B N   1 
ATOM 1435 C CA  . ASP B 1 110 ? 148.531 162.906 169.829 1.00 49.90  ? 109 ASP B CA  1 
ATOM 1436 C C   . ASP B 1 110 ? 147.791 164.226 169.939 1.00 49.90  ? 109 ASP B C   1 
ATOM 1437 O O   . ASP B 1 110 ? 147.671 164.792 171.029 1.00 49.90  ? 109 ASP B O   1 
ATOM 1438 C CB  . ASP B 1 110 ? 147.544 161.755 170.021 1.00 49.90  ? 109 ASP B CB  1 
ATOM 1439 C CG  . ASP B 1 110 ? 147.981 160.499 169.334 1.00 49.90  ? 109 ASP B CG  1 
ATOM 1440 O OD1 . ASP B 1 110 ? 148.552 160.602 168.235 1.00 49.90  ? 109 ASP B OD1 1 
ATOM 1441 O OD2 . ASP B 1 110 ? 147.770 159.409 169.892 1.00 49.90  ? 109 ASP B OD2 1 
ATOM 1442 N N   . HIS B 1 111 ? 147.275 164.693 168.798 1.00 51.81  ? 110 HIS B N   1 
ATOM 1443 C CA  . HIS B 1 111 ? 146.442 165.891 168.736 1.00 51.81  ? 110 HIS B CA  1 
ATOM 1444 C C   . HIS B 1 111 ? 147.173 167.084 169.353 1.00 51.81  ? 110 HIS B C   1 
ATOM 1445 O O   . HIS B 1 111 ? 146.823 167.586 170.419 1.00 51.81  ? 110 HIS B O   1 
ATOM 1446 C CB  . HIS B 1 111 ? 145.098 165.657 169.431 1.00 51.81  ? 110 HIS B CB  1 
ATOM 1447 C CG  . HIS B 1 111 ? 144.161 164.798 168.649 1.00 51.81  ? 110 HIS B CG  1 
ATOM 1448 N ND1 . HIS B 1 111 ? 143.676 165.166 167.413 1.00 51.81  ? 110 HIS B ND1 1 
ATOM 1449 C CD2 . HIS B 1 111 ? 143.632 163.582 168.916 1.00 51.81  ? 110 HIS B CD2 1 
ATOM 1450 C CE1 . HIS B 1 111 ? 142.884 164.216 166.954 1.00 51.81  ? 110 HIS B CE1 1 
ATOM 1451 N NE2 . HIS B 1 111 ? 142.839 163.244 167.847 1.00 51.81  ? 110 HIS B NE2 1 
ATOM 1452 N N   . CYS B 1 112 ? 148.235 167.487 168.676 1.00 53.26  ? 111 CYS B N   1 
ATOM 1453 C CA  . CYS B 1 112 ? 149.162 168.451 169.236 1.00 53.26  ? 111 CYS B CA  1 
ATOM 1454 C C   . CYS B 1 112 ? 149.342 169.631 168.298 1.00 53.26  ? 111 CYS B C   1 
ATOM 1455 O O   . CYS B 1 112 ? 149.188 169.512 167.084 1.00 53.26  ? 111 CYS B O   1 
ATOM 1456 C CB  . CYS B 1 112 ? 150.511 167.797 169.522 1.00 53.26  ? 111 CYS B CB  1 
ATOM 1457 S SG  . CYS B 1 112 ? 150.546 166.848 171.050 1.00 53.26  ? 111 CYS B SG  1 
ATOM 1458 N N   . ILE B 1 113 ? 149.672 170.778 168.877 1.00 54.83  ? 112 ILE B N   1 
ATOM 1459 C CA  . ILE B 1 113 ? 149.916 171.998 168.122 1.00 54.83  ? 112 ILE B CA  1 
ATOM 1460 C C   . ILE B 1 113 ? 151.339 172.439 168.406 1.00 54.83  ? 112 ILE B C   1 
ATOM 1461 O O   . ILE B 1 113 ? 151.689 172.721 169.557 1.00 54.83  ? 112 ILE B O   1 
ATOM 1462 C CB  . ILE B 1 113 ? 148.923 173.103 168.489 1.00 54.83  ? 112 ILE B CB  1 
ATOM 1463 C CG1 . ILE B 1 113 ? 147.513 172.537 168.510 1.00 54.83  ? 112 ILE B CG1 1 
ATOM 1464 C CG2 . ILE B 1 113 ? 148.983 174.202 167.474 1.00 54.83  ? 112 ILE B CG2 1 
ATOM 1465 C CD1 . ILE B 1 113 ? 146.539 173.385 169.266 1.00 54.83  ? 112 ILE B CD1 1 
ATOM 1466 N N   . ILE B 1 114 ? 152.153 172.506 167.363 1.00 55.39  ? 113 ILE B N   1 
ATOM 1467 C CA  . ILE B 1 114 ? 153.566 172.816 167.491 1.00 55.39  ? 113 ILE B CA  1 
ATOM 1468 C C   . ILE B 1 114 ? 153.821 174.105 166.735 1.00 55.39  ? 113 ILE B C   1 
ATOM 1469 O O   . ILE B 1 114 ? 153.703 174.141 165.506 1.00 55.39  ? 113 ILE B O   1 
ATOM 1470 C CB  . ILE B 1 114 ? 154.448 171.686 166.954 1.00 55.39  ? 113 ILE B CB  1 
ATOM 1471 C CG1 . ILE B 1 114 ? 154.330 170.458 167.841 1.00 55.39  ? 113 ILE B CG1 1 
ATOM 1472 C CG2 . ILE B 1 114 ? 155.870 172.124 166.906 1.00 55.39  ? 113 ILE B CG2 1 
ATOM 1473 C CD1 . ILE B 1 114 ? 154.417 169.176 167.088 1.00 55.39  ? 113 ILE B CD1 1 
ATOM 1474 N N   . GLY B 1 115 ? 154.167 175.152 167.451 1.00 58.61  ? 114 GLY B N   1 
ATOM 1475 C CA  . GLY B 1 115 ? 154.458 176.418 166.818 1.00 58.61  ? 114 GLY B CA  1 
ATOM 1476 C C   . GLY B 1 115 ? 154.003 177.562 167.692 1.00 58.61  ? 114 GLY B C   1 
ATOM 1477 O O   . GLY B 1 115 ? 153.555 177.371 168.815 1.00 58.61  ? 114 GLY B O   1 
ATOM 1478 N N   . ARG B 1 116 ? 154.133 178.765 167.146 1.00 63.63  ? 115 ARG B N   1 
ATOM 1479 C CA  . ARG B 1 116 ? 153.737 179.958 167.873 1.00 63.63  ? 115 ARG B CA  1 
ATOM 1480 C C   . ARG B 1 116 ? 152.248 180.202 167.722 1.00 63.63  ? 115 ARG B C   1 
ATOM 1481 O O   . ARG B 1 116 ? 151.677 179.978 166.652 1.00 63.63  ? 115 ARG B O   1 
ATOM 1482 C CB  . ARG B 1 116 ? 154.500 181.178 167.378 1.00 63.63  ? 115 ARG B CB  1 
ATOM 1483 C CG  . ARG B 1 116 ? 154.403 182.346 168.330 1.00 63.63  ? 115 ARG B CG  1 
ATOM 1484 C CD  . ARG B 1 116 ? 154.900 183.602 167.686 1.00 63.63  ? 115 ARG B CD  1 
ATOM 1485 N NE  . ARG B 1 116 ? 156.328 183.531 167.425 1.00 63.63  ? 115 ARG B NE  1 
ATOM 1486 C CZ  . ARG B 1 116 ? 156.954 184.300 166.547 1.00 63.63  ? 115 ARG B CZ  1 
ATOM 1487 N NH1 . ARG B 1 116 ? 158.260 184.175 166.367 1.00 63.63  ? 115 ARG B NH1 1 
ATOM 1488 N NH2 . ARG B 1 116 ? 156.267 185.191 165.843 1.00 63.63  ? 115 ARG B NH2 1 
ATOM 1489 N N   . THR B 1 117 ? 151.622 180.668 168.801 1.00 72.12  ? 116 THR B N   1 
ATOM 1490 C CA  . THR B 1 117 ? 150.189 180.909 168.810 1.00 72.12  ? 116 THR B CA  1 
ATOM 1491 C C   . THR B 1 117 ? 149.865 182.130 169.659 1.00 72.12  ? 116 THR B C   1 
ATOM 1492 O O   . THR B 1 117 ? 150.505 182.378 170.682 1.00 72.12  ? 116 THR B O   1 
ATOM 1493 C CB  . THR B 1 117 ? 149.428 179.695 169.345 1.00 72.12  ? 116 THR B CB  1 
ATOM 1494 O OG1 . THR B 1 117 ? 150.057 178.498 168.883 1.00 72.12  ? 116 THR B OG1 1 
ATOM 1495 C CG2 . THR B 1 117 ? 148.004 179.712 168.839 1.00 72.12  ? 116 THR B CG2 1 
ATOM 1496 N N   . LEU B 1 118 ? 148.863 182.885 169.228 1.00 80.48  ? 117 LEU B N   1 
ATOM 1497 C CA  . LEU B 1 118 ? 148.362 184.022 169.985 1.00 80.48  ? 117 LEU B CA  1 
ATOM 1498 C C   . LEU B 1 118 ? 146.950 184.303 169.505 1.00 80.48  ? 117 LEU B C   1 
ATOM 1499 O O   . LEU B 1 118 ? 146.661 184.192 168.313 1.00 80.48  ? 117 LEU B O   1 
ATOM 1500 C CB  . LEU B 1 118 ? 149.259 185.249 169.810 1.00 80.48  ? 117 LEU B CB  1 
ATOM 1501 C CG  . LEU B 1 118 ? 148.683 186.628 170.123 1.00 80.48  ? 117 LEU B CG  1 
ATOM 1502 C CD1 . LEU B 1 118 ? 148.357 186.760 171.561 1.00 80.48  ? 117 LEU B CD1 1 
ATOM 1503 C CD2 . LEU B 1 118 ? 149.657 187.704 169.708 1.00 80.48  ? 117 LEU B CD2 1 
ATOM 1504 N N   . VAL B 1 119 ? 146.069 184.621 170.443 1.00 84.64  ? 118 VAL B N   1 
ATOM 1505 C CA  . VAL B 1 119 ? 144.639 184.654 170.164 1.00 84.64  ? 118 VAL B CA  1 
ATOM 1506 C C   . VAL B 1 119 ? 144.037 185.976 170.633 1.00 84.64  ? 118 VAL B C   1 
ATOM 1507 O O   . VAL B 1 119 ? 142.952 186.014 171.219 1.00 84.64  ? 118 VAL B O   1 
ATOM 1508 C CB  . VAL B 1 119 ? 143.968 183.393 170.751 1.00 84.64  ? 118 VAL B CB  1 
ATOM 1509 C CG1 . VAL B 1 119 ? 144.213 183.288 172.197 1.00 84.64  ? 118 VAL B CG1 1 
ATOM 1510 C CG2 . VAL B 1 119 ? 142.468 183.294 170.410 1.00 84.64  ? 118 VAL B CG2 1 
ATOM 1511 N N   . VAL B 1 120 ? 144.783 187.066 170.456 1.00 88.86  ? 119 VAL B N   1 
ATOM 1512 C CA  . VAL B 1 120 ? 144.225 188.394 170.679 1.00 88.86  ? 119 VAL B CA  1 
ATOM 1513 C C   . VAL B 1 120 ? 142.891 188.541 169.959 1.00 88.86  ? 119 VAL B C   1 
ATOM 1514 O O   . VAL B 1 120 ? 142.690 188.018 168.859 1.00 88.86  ? 119 VAL B O   1 
ATOM 1515 C CB  . VAL B 1 120 ? 145.232 189.466 170.226 1.00 88.86  ? 119 VAL B CB  1 
ATOM 1516 C CG1 . VAL B 1 120 ? 145.538 189.302 168.768 1.00 88.86  ? 119 VAL B CG1 1 
ATOM 1517 C CG2 . VAL B 1 120 ? 144.690 190.854 170.495 1.00 88.86  ? 119 VAL B CG2 1 
ATOM 1518 N N   . HIS B 1 121 ? 141.969 189.262 170.589 1.00 96.80  ? 120 HIS B N   1 
ATOM 1519 C CA  . HIS B 1 121 ? 140.582 189.316 170.142 1.00 96.80  ? 120 HIS B CA  1 
ATOM 1520 C C   . HIS B 1 121 ? 140.057 190.710 170.451 1.00 96.80  ? 120 HIS B C   1 
ATOM 1521 O O   . HIS B 1 121 ? 140.026 191.102 171.621 1.00 96.80  ? 120 HIS B O   1 
ATOM 1522 C CB  . HIS B 1 121 ? 139.762 188.245 170.866 1.00 96.80  ? 120 HIS B CB  1 
ATOM 1523 C CG  . HIS B 1 121 ? 138.735 187.570 170.015 1.00 96.80  ? 120 HIS B CG  1 
ATOM 1524 N ND1 . HIS B 1 121 ? 139.019 186.463 169.247 1.00 96.80  ? 120 HIS B ND1 1 
ATOM 1525 C CD2 . HIS B 1 121 ? 137.417 187.822 169.839 1.00 96.80  ? 120 HIS B CD2 1 
ATOM 1526 C CE1 . HIS B 1 121 ? 137.924 186.071 168.621 1.00 96.80  ? 120 HIS B CE1 1 
ATOM 1527 N NE2 . HIS B 1 121 ? 136.938 186.879 168.963 1.00 96.80  ? 120 HIS B NE2 1 
ATOM 1528 N N   . GLU B 1 122 ? 139.659 191.466 169.427 1.00 110.58 ? 121 GLU B N   1 
ATOM 1529 C CA  . GLU B 1 122 ? 139.306 192.859 169.665 1.00 110.58 ? 121 GLU B CA  1 
ATOM 1530 C C   . GLU B 1 122 ? 138.205 193.334 168.728 1.00 110.58 ? 121 GLU B C   1 
ATOM 1531 O O   . GLU B 1 122 ? 137.938 192.731 167.690 1.00 110.58 ? 121 GLU B O   1 
ATOM 1532 C CB  . GLU B 1 122 ? 140.528 193.765 169.540 1.00 110.58 ? 121 GLU B CB  1 
ATOM 1533 C CG  . GLU B 1 122 ? 141.172 194.068 170.872 1.00 110.58 ? 121 GLU B CG  1 
ATOM 1534 C CD  . GLU B 1 122 ? 142.435 194.876 170.735 1.00 110.58 ? 121 GLU B CD  1 
ATOM 1535 O OE1 . GLU B 1 122 ? 143.027 194.866 169.638 1.00 110.58 ? 121 GLU B OE1 1 
ATOM 1536 O OE2 . GLU B 1 122 ? 142.835 195.522 171.723 1.00 110.58 ? 121 GLU B OE2 1 
ATOM 1537 N N   . LYS B 1 123 ? 137.571 194.437 169.127 1.00 121.51 ? 122 LYS B N   1 
ATOM 1538 C CA  . LYS B 1 123 ? 136.476 195.083 168.409 1.00 121.51 ? 122 LYS B CA  1 
ATOM 1539 C C   . LYS B 1 123 ? 136.415 196.530 168.873 1.00 121.51 ? 122 LYS B C   1 
ATOM 1540 O O   . LYS B 1 123 ? 136.893 196.861 169.959 1.00 121.51 ? 122 LYS B O   1 
ATOM 1541 C CB  . LYS B 1 123 ? 135.144 194.379 168.664 1.00 121.51 ? 122 LYS B CB  1 
ATOM 1542 C CG  . LYS B 1 123 ? 134.944 193.970 170.119 1.00 121.51 ? 122 LYS B CG  1 
ATOM 1543 C CD  . LYS B 1 123 ? 133.635 193.230 170.315 1.00 121.51 ? 122 LYS B CD  1 
ATOM 1544 C CE  . LYS B 1 123 ? 133.362 192.939 171.777 1.00 121.51 ? 122 LYS B CE  1 
ATOM 1545 N NZ  . LYS B 1 123 ? 134.466 192.171 172.407 1.00 121.51 ? 122 LYS B NZ  1 
ATOM 1546 N N   . ALA B 1 124 ? 135.803 197.390 168.059 1.00 134.74 ? 123 ALA B N   1 
ATOM 1547 C CA  . ALA B 1 124 ? 135.954 198.829 168.257 1.00 134.74 ? 123 ALA B CA  1 
ATOM 1548 C C   . ALA B 1 124 ? 134.688 199.531 168.741 1.00 134.74 ? 123 ALA B C   1 
ATOM 1549 O O   . ALA B 1 124 ? 134.712 200.158 169.803 1.00 134.74 ? 123 ALA B O   1 
ATOM 1550 C CB  . ALA B 1 124 ? 136.455 199.461 166.952 1.00 134.74 ? 123 ALA B CB  1 
ATOM 1551 N N   . ASP B 1 125 ? 133.597 199.484 167.971 1.00 142.39 ? 124 ASP B N   1 
ATOM 1552 C CA  . ASP B 1 125 ? 132.245 199.893 168.374 1.00 142.39 ? 124 ASP B CA  1 
ATOM 1553 C C   . ASP B 1 125 ? 132.115 201.078 169.336 1.00 142.39 ? 124 ASP B C   1 
ATOM 1554 O O   . ASP B 1 125 ? 131.532 200.930 170.414 1.00 142.39 ? 124 ASP B O   1 
ATOM 1555 C CB  . ASP B 1 125 ? 131.497 198.688 168.962 1.00 142.39 ? 124 ASP B CB  1 
ATOM 1556 C CG  . ASP B 1 125 ? 132.356 197.844 169.878 1.00 142.39 ? 124 ASP B CG  1 
ATOM 1557 O OD1 . ASP B 1 125 ? 132.955 198.394 170.819 1.00 142.39 ? 124 ASP B OD1 1 
ATOM 1558 O OD2 . ASP B 1 125 ? 132.440 196.621 169.642 1.00 142.39 ? 124 ASP B OD2 1 
ATOM 1559 N N   . ASP B 1 126 ? 132.613 202.255 168.962 1.00 144.14 ? 125 ASP B N   1 
ATOM 1560 C CA  . ASP B 1 126 ? 132.433 203.454 169.775 1.00 144.14 ? 125 ASP B CA  1 
ATOM 1561 C C   . ASP B 1 126 ? 131.167 204.198 169.362 1.00 144.14 ? 125 ASP B C   1 
ATOM 1562 O O   . ASP B 1 126 ? 130.682 204.073 168.236 1.00 144.14 ? 125 ASP B O   1 
ATOM 1563 C CB  . ASP B 1 126 ? 133.643 204.386 169.652 1.00 144.14 ? 125 ASP B CB  1 
ATOM 1564 C CG  . ASP B 1 126 ? 133.626 205.531 170.667 1.00 144.14 ? 125 ASP B CG  1 
ATOM 1565 O OD1 . ASP B 1 126 ? 132.580 206.188 170.839 1.00 144.14 ? 125 ASP B OD1 1 
ATOM 1566 O OD2 . ASP B 1 126 ? 134.675 205.784 171.290 1.00 144.14 ? 125 ASP B OD2 1 
ATOM 1567 N N   . LEU B 1 127 ? 130.637 204.996 170.298 1.00 144.38 ? 126 LEU B N   1 
ATOM 1568 C CA  . LEU B 1 127 ? 129.436 205.787 170.022 1.00 144.38 ? 126 LEU B CA  1 
ATOM 1569 C C   . LEU B 1 127 ? 129.401 207.006 170.949 1.00 144.38 ? 126 LEU B C   1 
ATOM 1570 O O   . LEU B 1 127 ? 128.973 206.901 172.099 1.00 144.38 ? 126 LEU B O   1 
ATOM 1571 C CB  . LEU B 1 127 ? 128.180 204.931 170.152 1.00 144.38 ? 126 LEU B CB  1 
ATOM 1572 C CG  . LEU B 1 127 ? 127.762 204.265 171.465 1.00 144.38 ? 126 LEU B CG  1 
ATOM 1573 C CD1 . LEU B 1 127 ? 126.283 203.937 171.443 1.00 144.38 ? 126 LEU B CD1 1 
ATOM 1574 C CD2 . LEU B 1 127 ? 128.579 203.005 171.695 1.00 144.38 ? 126 LEU B CD2 1 
ATOM 1575 N N   . GLY B 1 128 ? 129.806 208.158 170.426 1.00 142.90 ? 127 GLY B N   1 
ATOM 1576 C CA  . GLY B 1 128 ? 129.863 209.353 171.244 1.00 142.90 ? 127 GLY B CA  1 
ATOM 1577 C C   . GLY B 1 128 ? 130.931 210.321 170.784 1.00 142.90 ? 127 GLY B C   1 
ATOM 1578 O O   . GLY B 1 128 ? 130.935 210.736 169.624 1.00 142.90 ? 127 GLY B O   1 
ATOM 1579 N N   . LYS B 1 129 ? 131.829 210.703 171.688 1.00 140.86 ? 128 LYS B N   1 
ATOM 1580 C CA  . LYS B 1 129 ? 132.984 211.541 171.379 1.00 140.86 ? 128 LYS B CA  1 
ATOM 1581 C C   . LYS B 1 129 ? 134.256 210.887 171.893 1.00 140.86 ? 128 LYS B C   1 
ATOM 1582 O O   . LYS B 1 129 ? 135.064 211.498 172.594 1.00 140.86 ? 128 LYS B O   1 
ATOM 1583 C CB  . LYS B 1 129 ? 132.839 212.940 171.965 1.00 140.86 ? 128 LYS B CB  1 
ATOM 1584 C CG  . LYS B 1 129 ? 131.637 213.701 171.460 1.00 140.86 ? 128 LYS B CG  1 
ATOM 1585 C CD  . LYS B 1 129 ? 131.932 214.382 170.143 1.00 140.86 ? 128 LYS B CD  1 
ATOM 1586 C CE  . LYS B 1 129 ? 130.746 215.215 169.686 1.00 140.86 ? 128 LYS B CE  1 
ATOM 1587 N NZ  . LYS B 1 129 ? 131.004 215.893 168.386 1.00 140.86 ? 128 LYS B NZ  1 
ATOM 1588 N N   . GLY B 1 130 ? 134.443 209.618 171.551 1.00 139.65 ? 129 GLY B N   1 
ATOM 1589 C CA  . GLY B 1 130 ? 135.559 208.849 172.061 1.00 139.65 ? 129 GLY B CA  1 
ATOM 1590 C C   . GLY B 1 130 ? 136.697 208.726 171.073 1.00 139.65 ? 129 GLY B C   1 
ATOM 1591 O O   . GLY B 1 130 ? 137.538 209.623 170.963 1.00 139.65 ? 129 GLY B O   1 
ATOM 1592 N N   . GLY B 1 131 ? 136.742 207.603 170.365 1.00 138.16 ? 130 GLY B N   1 
ATOM 1593 C CA  . GLY B 1 131 ? 137.798 207.329 169.411 1.00 138.16 ? 130 GLY B CA  1 
ATOM 1594 C C   . GLY B 1 131 ? 138.562 206.083 169.793 1.00 138.16 ? 130 GLY B C   1 
ATOM 1595 O O   . GLY B 1 131 ? 139.384 206.097 170.714 1.00 138.16 ? 130 GLY B O   1 
ATOM 1596 N N   . ASN B 1 132 ? 138.308 205.000 169.073 1.00 134.72 ? 131 ASN B N   1 
ATOM 1597 C CA  . ASN B 1 132 ? 138.736 203.665 169.467 1.00 134.72 ? 131 ASN B CA  1 
ATOM 1598 C C   . ASN B 1 132 ? 139.935 203.203 168.650 1.00 134.72 ? 131 ASN B C   1 
ATOM 1599 O O   . ASN B 1 132 ? 139.857 203.060 167.424 1.00 134.72 ? 131 ASN B O   1 
ATOM 1600 C CB  . ASN B 1 132 ? 137.556 202.701 169.375 1.00 134.72 ? 131 ASN B CB  1 
ATOM 1601 C CG  . ASN B 1 132 ? 136.666 202.998 168.199 1.00 134.72 ? 131 ASN B CG  1 
ATOM 1602 O OD1 . ASN B 1 132 ? 136.966 203.873 167.396 1.00 134.72 ? 131 ASN B OD1 1 
ATOM 1603 N ND2 . ASN B 1 132 ? 135.541 202.309 168.115 1.00 134.72 ? 131 ASN B ND2 1 
ATOM 1604 N N   . GLU B 1 133 ? 141.038 202.965 169.355 1.00 124.78 ? 132 GLU B N   1 
ATOM 1605 C CA  . GLU B 1 133 ? 142.324 202.562 168.814 1.00 124.78 ? 132 GLU B CA  1 
ATOM 1606 C C   . GLU B 1 133 ? 142.810 201.377 169.632 1.00 124.78 ? 132 GLU B C   1 
ATOM 1607 O O   . GLU B 1 133 ? 142.553 201.309 170.835 1.00 124.78 ? 132 GLU B O   1 
ATOM 1608 C CB  . GLU B 1 133 ? 143.330 203.704 168.933 1.00 124.78 ? 132 GLU B CB  1 
ATOM 1609 C CG  . GLU B 1 133 ? 144.676 203.476 168.312 1.00 124.78 ? 132 GLU B CG  1 
ATOM 1610 C CD  . GLU B 1 133 ? 144.663 203.752 166.843 1.00 124.78 ? 132 GLU B CD  1 
ATOM 1611 O OE1 . GLU B 1 133 ? 143.835 204.585 166.424 1.00 124.78 ? 132 GLU B OE1 1 
ATOM 1612 O OE2 . GLU B 1 133 ? 145.484 203.153 166.118 1.00 124.78 ? 132 GLU B OE2 1 
ATOM 1613 N N   . GLU B 1 134 ? 143.507 200.442 168.992 1.00 117.43 ? 133 GLU B N   1 
ATOM 1614 C CA  . GLU B 1 134 ? 144.012 199.284 169.719 1.00 117.43 ? 133 GLU B CA  1 
ATOM 1615 C C   . GLU B 1 134 ? 145.283 198.765 169.064 1.00 117.43 ? 133 GLU B C   1 
ATOM 1616 O O   . GLU B 1 134 ? 145.384 198.715 167.836 1.00 117.43 ? 133 GLU B O   1 
ATOM 1617 C CB  . GLU B 1 134 ? 142.961 198.177 169.806 1.00 117.43 ? 133 GLU B CB  1 
ATOM 1618 C CG  . GLU B 1 134 ? 142.335 197.776 168.489 1.00 117.43 ? 133 GLU B CG  1 
ATOM 1619 C CD  . GLU B 1 134 ? 140.991 198.434 168.255 1.00 117.43 ? 133 GLU B CD  1 
ATOM 1620 O OE1 . GLU B 1 134 ? 140.743 199.506 168.841 1.00 117.43 ? 133 GLU B OE1 1 
ATOM 1621 O OE2 . GLU B 1 134 ? 140.176 197.865 167.500 1.00 117.43 ? 133 GLU B OE2 1 
ATOM 1622 N N   . SER B 1 135 ? 146.247 198.383 169.897 1.00 107.28 ? 134 SER B N   1 
ATOM 1623 C CA  . SER B 1 135 ? 147.600 198.087 169.436 1.00 107.28 ? 134 SER B CA  1 
ATOM 1624 C C   . SER B 1 135 ? 148.153 196.752 169.918 1.00 107.28 ? 134 SER B C   1 
ATOM 1625 O O   . SER B 1 135 ? 148.909 196.116 169.185 1.00 107.28 ? 134 SER B O   1 
ATOM 1626 C CB  . SER B 1 135 ? 148.526 199.226 169.875 1.00 107.28 ? 134 SER B CB  1 
ATOM 1627 O OG  . SER B 1 135 ? 148.305 199.560 171.233 1.00 107.28 ? 134 SER B OG  1 
ATOM 1628 N N   . THR B 1 136 ? 147.835 196.347 171.144 1.00 101.85 ? 135 THR B N   1 
ATOM 1629 C CA  . THR B 1 136 ? 148.224 195.062 171.744 1.00 101.85 ? 135 THR B CA  1 
ATOM 1630 C C   . THR B 1 136 ? 149.614 194.583 171.323 1.00 101.85 ? 135 THR B C   1 
ATOM 1631 O O   . THR B 1 136 ? 149.798 193.482 170.807 1.00 101.85 ? 135 THR B O   1 
ATOM 1632 C CB  . THR B 1 136 ? 147.172 193.975 171.497 1.00 101.85 ? 135 THR B CB  1 
ATOM 1633 O OG1 . THR B 1 136 ? 147.635 192.737 172.049 1.00 101.85 ? 135 THR B OG1 1 
ATOM 1634 C CG2 . THR B 1 136 ? 146.865 193.785 170.053 1.00 101.85 ? 135 THR B CG2 1 
ATOM 1635 N N   . LYS B 1 137 ? 150.611 195.414 171.596 1.00 99.68  ? 136 LYS B N   1 
ATOM 1636 C CA  . LYS B 1 137 ? 151.983 195.012 171.332 1.00 99.68  ? 136 LYS B CA  1 
ATOM 1637 C C   . LYS B 1 137 ? 152.430 193.955 172.339 1.00 99.68  ? 136 LYS B C   1 
ATOM 1638 O O   . LYS B 1 137 ? 151.848 193.808 173.414 1.00 99.68  ? 136 LYS B O   1 
ATOM 1639 C CB  . LYS B 1 137 ? 152.908 196.226 171.382 1.00 99.68  ? 136 LYS B CB  1 
ATOM 1640 C CG  . LYS B 1 137 ? 153.719 196.381 172.658 1.00 99.68  ? 136 LYS B CG  1 
ATOM 1641 C CD  . LYS B 1 137 ? 154.591 197.626 172.581 1.00 99.68  ? 136 LYS B CD  1 
ATOM 1642 C CE  . LYS B 1 137 ? 155.555 197.730 173.747 1.00 99.68  ? 136 LYS B CE  1 
ATOM 1643 N NZ  . LYS B 1 137 ? 156.418 196.528 173.898 1.00 99.68  ? 136 LYS B NZ  1 
ATOM 1644 N N   . THR B 1 138 ? 153.478 193.208 171.985 1.00 96.43  ? 137 THR B N   1 
ATOM 1645 C CA  . THR B 1 138 ? 154.009 192.182 172.877 1.00 96.43  ? 137 THR B CA  1 
ATOM 1646 C C   . THR B 1 138 ? 155.382 192.540 173.430 1.00 96.43  ? 137 THR B C   1 
ATOM 1647 O O   . THR B 1 138 ? 155.549 192.664 174.645 1.00 96.43  ? 137 THR B O   1 
ATOM 1648 C CB  . THR B 1 138 ? 154.095 190.830 172.162 1.00 96.43  ? 137 THR B CB  1 
ATOM 1649 O OG1 . THR B 1 138 ? 155.228 190.842 171.288 1.00 96.43  ? 137 THR B OG1 1 
ATOM 1650 C CG2 . THR B 1 138 ? 152.848 190.566 171.347 1.00 96.43  ? 137 THR B CG2 1 
ATOM 1651 N N   . GLY B 1 139 ? 156.371 192.738 172.571 1.00 93.09  ? 138 GLY B N   1 
ATOM 1652 C CA  . GLY B 1 139 ? 157.719 192.927 173.061 1.00 93.09  ? 138 GLY B CA  1 
ATOM 1653 C C   . GLY B 1 139 ? 158.715 192.041 172.352 1.00 93.09  ? 138 GLY B C   1 
ATOM 1654 O O   . GLY B 1 139 ? 158.435 190.870 172.091 1.00 93.09  ? 138 GLY B O   1 
ATOM 1655 N N   . ASN B 1 140 ? 159.884 192.590 172.035 1.00 93.29  ? 139 ASN B N   1 
ATOM 1656 C CA  . ASN B 1 140 ? 160.853 191.873 171.227 1.00 93.29  ? 139 ASN B CA  1 
ATOM 1657 C C   . ASN B 1 140 ? 161.511 190.752 172.025 1.00 93.29  ? 139 ASN B C   1 
ATOM 1658 O O   . ASN B 1 140 ? 161.416 190.672 173.252 1.00 93.29  ? 139 ASN B O   1 
ATOM 1659 C CB  . ASN B 1 140 ? 161.927 192.821 170.700 1.00 93.29  ? 139 ASN B CB  1 
ATOM 1660 C CG  . ASN B 1 140 ? 161.390 193.809 169.700 1.00 93.29  ? 139 ASN B CG  1 
ATOM 1661 O OD1 . ASN B 1 140 ? 160.284 193.653 169.188 1.00 93.29  ? 139 ASN B OD1 1 
ATOM 1662 N ND2 . ASN B 1 140 ? 162.177 194.836 169.407 1.00 93.29  ? 139 ASN B ND2 1 
ATOM 1663 N N   . ALA B 1 141 ? 162.196 189.876 171.298 1.00 87.48  ? 140 ALA B N   1 
ATOM 1664 C CA  . ALA B 1 141 ? 162.988 188.827 171.911 1.00 87.48  ? 140 ALA B CA  1 
ATOM 1665 C C   . ALA B 1 141 ? 164.170 188.528 171.009 1.00 87.48  ? 140 ALA B C   1 
ATOM 1666 O O   . ALA B 1 141 ? 164.165 188.847 169.818 1.00 87.48  ? 140 ALA B O   1 
ATOM 1667 C CB  . ALA B 1 141 ? 162.163 187.561 172.155 1.00 87.48  ? 140 ALA B CB  1 
ATOM 1668 N N   . GLY B 1 142 ? 165.185 187.908 171.589 1.00 78.83  ? 141 GLY B N   1 
ATOM 1669 C CA  . GLY B 1 142 ? 166.337 187.505 170.810 1.00 78.83  ? 141 GLY B CA  1 
ATOM 1670 C C   . GLY B 1 142 ? 167.307 186.754 171.684 1.00 78.83  ? 141 GLY B C   1 
ATOM 1671 O O   . GLY B 1 142 ? 167.059 186.525 172.871 1.00 78.83  ? 141 GLY B O   1 
ATOM 1672 N N   . SER B 1 143 ? 168.435 186.381 171.079 1.00 73.42  ? 142 SER B N   1 
ATOM 1673 C CA  . SER B 1 143 ? 169.522 185.692 171.773 1.00 73.42  ? 142 SER B CA  1 
ATOM 1674 C C   . SER B 1 143 ? 169.023 184.383 172.391 1.00 73.42  ? 142 SER B C   1 
ATOM 1675 O O   . SER B 1 143 ? 168.926 184.217 173.610 1.00 73.42  ? 142 SER B O   1 
ATOM 1676 C CB  . SER B 1 143 ? 170.166 186.594 172.830 1.00 73.42  ? 142 SER B CB  1 
ATOM 1677 O OG  . SER B 1 143 ? 169.225 186.984 173.808 1.00 73.42  ? 142 SER B OG  1 
ATOM 1678 N N   . ARG B 1 144 ? 168.655 183.475 171.491 1.00 66.79  ? 143 ARG B N   1 
ATOM 1679 C CA  . ARG B 1 144 ? 168.451 182.078 171.835 1.00 66.79  ? 143 ARG B CA  1 
ATOM 1680 C C   . ARG B 1 144 ? 169.069 181.218 170.751 1.00 66.79  ? 143 ARG B C   1 
ATOM 1681 O O   . ARG B 1 144 ? 169.130 181.617 169.592 1.00 66.79  ? 143 ARG B O   1 
ATOM 1682 C CB  . ARG B 1 144 ? 166.974 181.724 172.003 1.00 66.79  ? 143 ARG B CB  1 
ATOM 1683 C CG  . ARG B 1 144 ? 166.180 181.769 170.727 1.00 66.79  ? 143 ARG B CG  1 
ATOM 1684 C CD  . ARG B 1 144 ? 164.732 181.500 171.016 1.00 66.79  ? 143 ARG B CD  1 
ATOM 1685 N NE  . ARG B 1 144 ? 163.868 182.295 170.160 1.00 66.79  ? 143 ARG B NE  1 
ATOM 1686 C CZ  . ARG B 1 144 ? 162.564 182.429 170.346 1.00 66.79  ? 143 ARG B CZ  1 
ATOM 1687 N NH1 . ARG B 1 144 ? 161.972 181.816 171.361 1.00 66.79  ? 143 ARG B NH1 1 
ATOM 1688 N NH2 . ARG B 1 144 ? 161.853 183.175 169.517 1.00 66.79  ? 143 ARG B NH2 1 
ATOM 1689 N N   . LEU B 1 145 ? 169.554 180.047 171.135 1.00 63.52  ? 144 LEU B N   1 
ATOM 1690 C CA  . LEU B 1 145 ? 170.021 179.114 170.126 1.00 63.52  ? 144 LEU B CA  1 
ATOM 1691 C C   . LEU B 1 145 ? 169.881 177.711 170.680 1.00 63.52  ? 144 LEU B C   1 
ATOM 1692 O O   . LEU B 1 145 ? 169.922 177.503 171.893 1.00 63.52  ? 144 LEU B O   1 
ATOM 1693 C CB  . LEU B 1 145 ? 171.460 179.412 169.706 1.00 63.52  ? 144 LEU B CB  1 
ATOM 1694 C CG  . LEU B 1 145 ? 172.016 178.697 168.479 1.00 63.52  ? 144 LEU B CG  1 
ATOM 1695 C CD1 . LEU B 1 145 ? 172.992 179.582 167.769 1.00 63.52  ? 144 LEU B CD1 1 
ATOM 1696 C CD2 . LEU B 1 145 ? 172.701 177.425 168.863 1.00 63.52  ? 144 LEU B CD2 1 
ATOM 1697 N N   . ALA B 1 146 ? 169.681 176.758 169.779 1.00 59.53  ? 145 ALA B N   1 
ATOM 1698 C CA  . ALA B 1 146 ? 169.470 175.367 170.147 1.00 59.53  ? 145 ALA B CA  1 
ATOM 1699 C C   . ALA B 1 146 ? 170.579 174.534 169.535 1.00 59.53  ? 145 ALA B C   1 
ATOM 1700 O O   . ALA B 1 146 ? 170.764 174.552 168.314 1.00 59.53  ? 145 ALA B O   1 
ATOM 1701 C CB  . ALA B 1 146 ? 168.108 174.880 169.665 1.00 59.53  ? 145 ALA B CB  1 
ATOM 1702 N N   . CYS B 1 147 ? 171.314 173.809 170.372 1.00 58.89  ? 146 CYS B N   1 
ATOM 1703 C CA  . CYS B 1 147 ? 172.418 173.006 169.875 1.00 58.89  ? 146 CYS B CA  1 
ATOM 1704 C C   . CYS B 1 147 ? 172.306 171.580 170.380 1.00 58.89  ? 146 CYS B C   1 
ATOM 1705 O O   . CYS B 1 147 ? 171.996 171.345 171.550 1.00 58.89  ? 146 CYS B O   1 
ATOM 1706 C CB  . CYS B 1 147 ? 173.773 173.594 170.277 1.00 58.89  ? 146 CYS B CB  1 
ATOM 1707 S SG  . CYS B 1 147 ? 174.427 173.072 171.862 1.00 58.89  ? 146 CYS B SG  1 
ATOM 1708 N N   . GLY B 1 148 ? 172.551 170.632 169.482 1.00 50.76  ? 147 GLY B N   1 
ATOM 1709 C CA  . GLY B 1 148 ? 172.652 169.243 169.874 1.00 50.76  ? 147 GLY B CA  1 
ATOM 1710 C C   . GLY B 1 148 ? 171.523 168.355 169.408 1.00 50.76  ? 147 GLY B C   1 
ATOM 1711 O O   . GLY B 1 148 ? 171.261 168.241 168.210 1.00 50.76  ? 147 GLY B O   1 
ATOM 1712 N N   . VAL B 1 149 ? 170.860 167.705 170.357 1.00 45.32  ? 148 VAL B N   1 
ATOM 1713 C CA  . VAL B 1 149 ? 169.759 166.795 170.078 1.00 45.32  ? 148 VAL B CA  1 
ATOM 1714 C C   . VAL B 1 149 ? 168.572 167.214 170.939 1.00 45.32  ? 148 VAL B C   1 
ATOM 1715 O O   . VAL B 1 149 ? 168.619 167.113 172.169 1.00 45.32  ? 148 VAL B O   1 
ATOM 1716 C CB  . VAL B 1 149 ? 170.149 165.329 170.309 1.00 45.32  ? 148 VAL B CB  1 
ATOM 1717 C CG1 . VAL B 1 149 ? 170.746 165.119 171.690 1.00 45.32  ? 148 VAL B CG1 1 
ATOM 1718 C CG2 . VAL B 1 149 ? 168.958 164.431 170.090 1.00 45.32  ? 148 VAL B CG2 1 
ATOM 1719 N N   . ILE B 1 150 ? 167.516 167.707 170.294 1.00 45.42  ? 149 ILE B N   1 
ATOM 1720 C CA  . ILE B 1 150 ? 166.466 168.421 171.004 1.00 45.42  ? 149 ILE B CA  1 
ATOM 1721 C C   . ILE B 1 150 ? 165.098 167.773 170.851 1.00 45.42  ? 149 ILE B C   1 
ATOM 1722 O O   . ILE B 1 150 ? 164.495 167.357 171.839 1.00 45.42  ? 149 ILE B O   1 
ATOM 1723 C CB  . ILE B 1 150 ? 166.407 169.881 170.552 1.00 45.42  ? 149 ILE B CB  1 
ATOM 1724 C CG1 . ILE B 1 150 ? 167.796 170.495 170.583 1.00 45.42  ? 149 ILE B CG1 1 
ATOM 1725 C CG2 . ILE B 1 150 ? 165.524 170.647 171.487 1.00 45.42  ? 149 ILE B CG2 1 
ATOM 1726 C CD1 . ILE B 1 150 ? 168.308 170.735 171.963 1.00 45.42  ? 149 ILE B CD1 1 
ATOM 1727 N N   . GLY B 1 151 ? 164.588 167.669 169.636 1.00 45.36  ? 150 GLY B N   1 
ATOM 1728 C CA  . GLY B 1 151 ? 163.175 167.365 169.532 1.00 45.36  ? 150 GLY B CA  1 
ATOM 1729 C C   . GLY B 1 151 ? 162.400 168.556 169.014 1.00 45.36  ? 150 GLY B C   1 
ATOM 1730 O O   . GLY B 1 151 ? 162.381 168.803 167.806 1.00 45.36  ? 150 GLY B O   1 
ATOM 1731 N N   . ILE B 1 152 ? 161.729 169.281 169.900 1.00 45.33  ? 151 ILE B N   1 
ATOM 1732 C CA  . ILE B 1 152 ? 161.159 170.578 169.565 1.00 45.33  ? 151 ILE B CA  1 
ATOM 1733 C C   . ILE B 1 152 ? 162.095 171.652 170.080 1.00 45.33  ? 151 ILE B C   1 
ATOM 1734 O O   . ILE B 1 152 ? 162.343 171.744 171.287 1.00 45.33  ? 151 ILE B O   1 
ATOM 1735 C CB  . ILE B 1 152 ? 159.763 170.763 170.163 1.00 45.33  ? 151 ILE B CB  1 
ATOM 1736 C CG1 . ILE B 1 152 ? 158.888 169.566 169.859 1.00 45.33  ? 151 ILE B CG1 1 
ATOM 1737 C CG2 . ILE B 1 152 ? 159.145 171.999 169.600 1.00 45.33  ? 151 ILE B CG2 1 
ATOM 1738 C CD1 . ILE B 1 152 ? 157.975 169.242 170.980 1.00 45.33  ? 151 ILE B CD1 1 
ATOM 1739 N N   . ALA B 1 153 ? 162.611 172.468 169.172 1.00 48.39  ? 152 ALA B N   1 
ATOM 1740 C CA  . ALA B 1 153 ? 163.448 173.607 169.518 1.00 48.39  ? 152 ALA B CA  1 
ATOM 1741 C C   . ALA B 1 153 ? 162.762 174.859 169.011 1.00 48.39  ? 152 ALA B C   1 
ATOM 1742 O O   . ALA B 1 153 ? 162.548 175.004 167.805 1.00 48.39  ? 152 ALA B O   1 
ATOM 1743 C CB  . ALA B 1 153 ? 164.841 173.479 168.911 1.00 48.39  ? 152 ALA B CB  1 
ATOM 1744 N N   . GLN B 1 154 ? 162.417 175.752 169.924 1.00 52.34  ? 153 GLN B N   1 
ATOM 1745 C CA  . GLN B 1 154 ? 161.729 176.975 169.557 1.00 52.34  ? 153 GLN B CA  1 
ATOM 1746 C C   . GLN B 1 154 ? 162.016 178.087 170.558 1.00 52.34  ? 153 GLN B C   1 
ATOM 1747 O O   . GLN B 1 154 ? 162.540 179.143 170.198 1.00 52.34  ? 153 GLN B O   1 
ATOM 1748 C CB  . GLN B 1 154 ? 160.231 176.725 169.462 1.00 52.34  ? 153 GLN B CB  1 
ATOM 1749 C CG  . GLN B 1 154 ? 159.648 176.149 170.719 1.00 52.34  ? 153 GLN B CG  1 
ATOM 1750 C CD  . GLN B 1 154 ? 158.284 175.557 170.501 1.00 52.34  ? 153 GLN B CD  1 
ATOM 1751 O OE1 . GLN B 1 154 ? 157.861 175.340 169.369 1.00 52.34  ? 153 GLN B OE1 1 
ATOM 1752 N NE2 . GLN B 1 154 ? 157.580 175.293 171.589 1.00 52.34  ? 153 GLN B NE2 1 
ATOM 1753 N N   . LYS C 1 4   ? 192.999 131.482 163.446 1.00 75.25  ? 3   LYS C N   1 
ATOM 1754 C CA  . LYS C 1 4   ? 191.816 132.105 164.032 1.00 75.25  ? 3   LYS C CA  1 
ATOM 1755 C C   . LYS C 1 4   ? 192.141 133.467 164.627 1.00 75.25  ? 3   LYS C C   1 
ATOM 1756 O O   . LYS C 1 4   ? 192.237 133.607 165.842 1.00 75.25  ? 3   LYS C O   1 
ATOM 1757 C CB  . LYS C 1 4   ? 191.219 131.198 165.105 1.00 75.25  ? 3   LYS C CB  1 
ATOM 1758 C CG  . LYS C 1 4   ? 189.852 131.626 165.573 1.00 75.25  ? 3   LYS C CG  1 
ATOM 1759 C CD  . LYS C 1 4   ? 188.878 131.653 164.417 1.00 75.25  ? 3   LYS C CD  1 
ATOM 1760 C CE  . LYS C 1 4   ? 188.657 130.266 163.861 1.00 75.25  ? 3   LYS C CE  1 
ATOM 1761 N NZ  . LYS C 1 4   ? 187.949 129.406 164.836 1.00 75.25  ? 3   LYS C NZ  1 
ATOM 1762 N N   . ALA C 1 5   ? 192.313 134.467 163.773 1.00 74.10  ? 4   ALA C N   1 
ATOM 1763 C CA  . ALA C 1 5   ? 192.648 135.812 164.220 1.00 74.10  ? 4   ALA C CA  1 
ATOM 1764 C C   . ALA C 1 5   ? 192.352 136.778 163.083 1.00 74.10  ? 4   ALA C C   1 
ATOM 1765 O O   . ALA C 1 5   ? 191.804 136.392 162.048 1.00 74.10  ? 4   ALA C O   1 
ATOM 1766 C CB  . ALA C 1 5   ? 194.106 135.893 164.676 1.00 74.10  ? 4   ALA C CB  1 
ATOM 1767 N N   . VAL C 1 6   ? 192.707 138.043 163.279 1.00 72.68  ? 5   VAL C N   1 
ATOM 1768 C CA  . VAL C 1 6   ? 192.529 139.073 162.270 1.00 72.68  ? 5   VAL C CA  1 
ATOM 1769 C C   . VAL C 1 6   ? 193.853 139.463 161.632 1.00 72.68  ? 5   VAL C C   1 
ATOM 1770 O O   . VAL C 1 6   ? 193.918 139.701 160.425 1.00 72.68  ? 5   VAL C O   1 
ATOM 1771 C CB  . VAL C 1 6   ? 191.822 140.303 162.873 1.00 72.68  ? 5   VAL C CB  1 
ATOM 1772 C CG1 . VAL C 1 6   ? 191.524 141.327 161.815 1.00 72.68  ? 5   VAL C CG1 1 
ATOM 1773 C CG2 . VAL C 1 6   ? 190.538 139.874 163.529 1.00 72.68  ? 5   VAL C CG2 1 
ATOM 1774 N N   . CYS C 1 7   ? 194.915 139.531 162.425 1.00 80.09  ? 6   CYS C N   1 
ATOM 1775 C CA  . CYS C 1 7   ? 196.262 139.697 161.908 1.00 80.09  ? 6   CYS C CA  1 
ATOM 1776 C C   . CYS C 1 7   ? 197.179 138.726 162.627 1.00 80.09  ? 6   CYS C C   1 
ATOM 1777 O O   . CYS C 1 7   ? 196.953 138.383 163.790 1.00 80.09  ? 6   CYS C O   1 
ATOM 1778 C CB  . CYS C 1 7   ? 196.786 141.119 162.101 1.00 80.09  ? 6   CYS C CB  1 
ATOM 1779 S SG  . CYS C 1 7   ? 197.427 141.430 163.760 1.00 80.09  ? 6   CYS C SG  1 
ATOM 1780 N N   . VAL C 1 8   ? 198.206 138.270 161.922 1.00 79.77  ? 7   VAL C N   1 
ATOM 1781 C CA  . VAL C 1 8   ? 199.296 137.526 162.532 1.00 79.77  ? 7   VAL C CA  1 
ATOM 1782 C C   . VAL C 1 8   ? 200.577 138.291 162.249 1.00 79.77  ? 7   VAL C C   1 
ATOM 1783 O O   . VAL C 1 8   ? 200.799 138.749 161.122 1.00 79.77  ? 7   VAL C O   1 
ATOM 1784 C CB  . VAL C 1 8   ? 199.367 136.076 162.022 1.00 79.77  ? 7   VAL C CB  1 
ATOM 1785 C CG1 . VAL C 1 8   ? 198.005 135.423 162.122 1.00 79.77  ? 7   VAL C CG1 1 
ATOM 1786 C CG2 . VAL C 1 8   ? 199.870 136.014 160.605 1.00 79.77  ? 7   VAL C CG2 1 
ATOM 1787 N N   . LEU C 1 9   ? 201.391 138.478 163.278 1.00 84.63  ? 8   LEU C N   1 
ATOM 1788 C CA  . LEU C 1 9   ? 202.581 139.306 163.170 1.00 84.63  ? 8   LEU C CA  1 
ATOM 1789 C C   . LEU C 1 9   ? 203.810 138.476 163.495 1.00 84.63  ? 8   LEU C C   1 
ATOM 1790 O O   . LEU C 1 9   ? 203.907 137.894 164.581 1.00 84.63  ? 8   LEU C O   1 
ATOM 1791 C CB  . LEU C 1 9   ? 202.494 140.522 164.087 1.00 84.63  ? 8   LEU C CB  1 
ATOM 1792 C CG  . LEU C 1 9   ? 203.624 141.532 163.876 1.00 84.63  ? 8   LEU C CG  1 
ATOM 1793 C CD1 . LEU C 1 9   ? 203.966 141.656 162.423 1.00 84.63  ? 8   LEU C CD1 1 
ATOM 1794 C CD2 . LEU C 1 9   ? 203.265 142.884 164.412 1.00 84.63  ? 8   LEU C CD2 1 
ATOM 1795 N N   . LYS C 1 10  ? 204.740 138.430 162.560 1.00 86.06  ? 9   LYS C N   1 
ATOM 1796 C CA  . LYS C 1 10  ? 206.012 137.756 162.742 1.00 86.06  ? 9   LYS C CA  1 
ATOM 1797 C C   . LYS C 1 10  ? 207.191 138.702 162.658 1.00 86.06  ? 9   LYS C C   1 
ATOM 1798 O O   . LYS C 1 10  ? 208.075 138.647 163.511 1.00 86.06  ? 9   LYS C O   1 
ATOM 1799 C CB  . LYS C 1 10  ? 206.163 136.651 161.701 1.00 86.06  ? 9   LYS C CB  1 
ATOM 1800 C CG  . LYS C 1 10  ? 204.949 135.751 161.618 1.00 86.06  ? 9   LYS C CG  1 
ATOM 1801 C CD  . LYS C 1 10  ? 205.033 134.808 160.437 1.00 86.06  ? 9   LYS C CD  1 
ATOM 1802 C CE  . LYS C 1 10  ? 203.813 133.918 160.390 1.00 86.06  ? 9   LYS C CE  1 
ATOM 1803 N NZ  . LYS C 1 10  ? 203.465 133.419 161.751 1.00 86.06  ? 9   LYS C NZ  1 
ATOM 1804 N N   . GLY C 1 11  ? 207.218 139.581 161.665 1.00 87.06  ? 10  GLY C N   1 
ATOM 1805 C CA  . GLY C 1 11  ? 208.273 140.568 161.555 1.00 87.06  ? 10  GLY C CA  1 
ATOM 1806 C C   . GLY C 1 11  ? 208.251 141.593 162.668 1.00 87.06  ? 10  GLY C C   1 
ATOM 1807 O O   . GLY C 1 11  ? 207.629 141.378 163.711 1.00 87.06  ? 10  GLY C O   1 
ATOM 1808 N N   . ASP C 1 12  ? 208.919 142.718 162.461 1.00 90.29  ? 11  ASP C N   1 
ATOM 1809 C CA  . ASP C 1 12  ? 209.089 143.709 163.511 1.00 90.29  ? 11  ASP C CA  1 
ATOM 1810 C C   . ASP C 1 12  ? 208.106 144.863 163.355 1.00 90.29  ? 11  ASP C C   1 
ATOM 1811 O O   . ASP C 1 12  ? 207.599 145.139 162.266 1.00 90.29  ? 11  ASP C O   1 
ATOM 1812 C CB  . ASP C 1 12  ? 210.516 144.248 163.508 1.00 90.29  ? 11  ASP C CB  1 
ATOM 1813 C CG  . ASP C 1 12  ? 210.947 144.714 162.150 1.00 90.29  ? 11  ASP C CG  1 
ATOM 1814 O OD1 . ASP C 1 12  ? 210.356 145.693 161.651 1.00 90.29  ? 11  ASP C OD1 1 
ATOM 1815 O OD2 . ASP C 1 12  ? 211.870 144.102 161.576 1.00 90.29  ? 11  ASP C OD2 1 
ATOM 1816 N N   . GLY C 1 13  ? 207.854 145.545 164.469 1.00 84.28  ? 12  GLY C N   1 
ATOM 1817 C CA  . GLY C 1 13  ? 207.024 146.725 164.467 1.00 84.28  ? 12  GLY C CA  1 
ATOM 1818 C C   . GLY C 1 13  ? 205.899 146.643 165.473 1.00 84.28  ? 12  GLY C C   1 
ATOM 1819 O O   . GLY C 1 13  ? 205.305 145.586 165.687 1.00 84.28  ? 12  GLY C O   1 
ATOM 1820 N N   . PRO C 1 14  ? 205.591 147.759 166.120 1.00 75.68  ? 13  PRO C N   1 
ATOM 1821 C CA  . PRO C 1 14  ? 204.435 147.802 167.012 1.00 75.68  ? 13  PRO C CA  1 
ATOM 1822 C C   . PRO C 1 14  ? 203.145 148.024 166.232 1.00 75.68  ? 13  PRO C C   1 
ATOM 1823 O O   . PRO C 1 14  ? 203.145 148.472 165.085 1.00 75.68  ? 13  PRO C O   1 
ATOM 1824 C CB  . PRO C 1 14  ? 204.751 148.989 167.920 1.00 75.68  ? 13  PRO C CB  1 
ATOM 1825 C CG  . PRO C 1 14  ? 205.542 149.884 167.053 1.00 75.68  ? 13  PRO C CG  1 
ATOM 1826 C CD  . PRO C 1 14  ? 206.353 149.013 166.149 1.00 75.68  ? 13  PRO C CD  1 
ATOM 1827 N N   . VAL C 1 15  ? 202.029 147.708 166.885 1.00 65.94  ? 14  VAL C N   1 
ATOM 1828 C CA  . VAL C 1 15  ? 200.752 147.618 166.189 1.00 65.94  ? 14  VAL C CA  1 
ATOM 1829 C C   . VAL C 1 15  ? 199.795 148.718 166.619 1.00 65.94  ? 14  VAL C C   1 
ATOM 1830 O O   . VAL C 1 15  ? 200.099 149.519 167.505 1.00 65.94  ? 14  VAL C O   1 
ATOM 1831 C CB  . VAL C 1 15  ? 200.103 146.245 166.404 1.00 65.94  ? 14  VAL C CB  1 
ATOM 1832 C CG1 . VAL C 1 15  ? 201.052 145.155 166.014 1.00 65.94  ? 14  VAL C CG1 1 
ATOM 1833 C CG2 . VAL C 1 15  ? 199.702 146.101 167.824 1.00 65.94  ? 14  VAL C CG2 1 
ATOM 1834 N N   . GLN C 1 16  ? 198.615 148.726 166.014 1.00 57.61  ? 15  GLN C N   1 
ATOM 1835 C CA  . GLN C 1 16  ? 197.686 149.848 166.042 1.00 57.61  ? 15  GLN C CA  1 
ATOM 1836 C C   . GLN C 1 16  ? 196.285 149.243 166.038 1.00 57.61  ? 15  GLN C C   1 
ATOM 1837 O O   . GLN C 1 16  ? 196.078 148.107 166.474 1.00 57.61  ? 15  GLN C O   1 
ATOM 1838 C CB  . GLN C 1 16  ? 197.975 150.797 164.867 1.00 57.61  ? 15  GLN C CB  1 
ATOM 1839 C CG  . GLN C 1 16  ? 197.237 152.136 164.858 1.00 57.61  ? 15  GLN C CG  1 
ATOM 1840 C CD  . GLN C 1 16  ? 197.764 153.142 165.851 1.00 57.61  ? 15  GLN C CD  1 
ATOM 1841 O OE1 . GLN C 1 16  ? 198.062 152.811 166.991 1.00 57.61  ? 15  GLN C OE1 1 
ATOM 1842 N NE2 . GLN C 1 16  ? 197.860 154.389 165.423 1.00 57.61  ? 15  GLN C NE2 1 
ATOM 1843 N N   . GLY C 1 17  ? 195.292 150.011 165.619 1.00 54.82  ? 16  GLY C N   1 
ATOM 1844 C CA  . GLY C 1 17  ? 193.938 149.506 165.562 1.00 54.82  ? 16  GLY C CA  1 
ATOM 1845 C C   . GLY C 1 17  ? 193.712 148.329 164.636 1.00 54.82  ? 16  GLY C C   1 
ATOM 1846 O O   . GLY C 1 17  ? 193.809 148.450 163.413 1.00 54.82  ? 16  GLY C O   1 
ATOM 1847 N N   . ILE C 1 18  ? 193.421 147.177 165.231 1.00 55.29  ? 17  ILE C N   1 
ATOM 1848 C CA  . ILE C 1 18  ? 192.878 146.017 164.538 1.00 55.29  ? 17  ILE C CA  1 
ATOM 1849 C C   . ILE C 1 18  ? 191.608 145.626 165.274 1.00 55.29  ? 17  ILE C C   1 
ATOM 1850 O O   . ILE C 1 18  ? 191.636 145.450 166.495 1.00 55.29  ? 17  ILE C O   1 
ATOM 1851 C CB  . ILE C 1 18  ? 193.875 144.844 164.511 1.00 55.29  ? 17  ILE C CB  1 
ATOM 1852 C CG1 . ILE C 1 18  ? 195.298 145.345 164.299 1.00 55.29  ? 17  ILE C CG1 1 
ATOM 1853 C CG2 . ILE C 1 18  ? 193.521 143.866 163.418 1.00 55.29  ? 17  ILE C CG2 1 
ATOM 1854 C CD1 . ILE C 1 18  ? 195.539 145.864 162.925 1.00 55.29  ? 17  ILE C CD1 1 
ATOM 1855 N N   . ILE C 1 19  ? 190.492 145.510 164.553 1.00 52.29  ? 18  ILE C N   1 
ATOM 1856 C CA  . ILE C 1 19  ? 189.214 145.306 165.224 1.00 52.29  ? 18  ILE C CA  1 
ATOM 1857 C C   . ILE C 1 19  ? 188.452 144.154 164.584 1.00 52.29  ? 18  ILE C C   1 
ATOM 1858 O O   . ILE C 1 19  ? 188.536 143.935 163.372 1.00 52.29  ? 18  ILE C O   1 
ATOM 1859 C CB  . ILE C 1 19  ? 188.322 146.566 165.184 1.00 52.29  ? 18  ILE C CB  1 
ATOM 1860 C CG1 . ILE C 1 19  ? 189.112 147.845 165.438 1.00 52.29  ? 18  ILE C CG1 1 
ATOM 1861 C CG2 . ILE C 1 19  ? 187.279 146.476 166.271 1.00 52.29  ? 18  ILE C CG2 1 
ATOM 1862 C CD1 . ILE C 1 19  ? 189.511 148.569 164.176 1.00 52.29  ? 18  ILE C CD1 1 
ATOM 1863 N N   . ASN C 1 20  ? 187.674 143.435 165.406 1.00 53.73  ? 19  ASN C N   1 
ATOM 1864 C CA  . ASN C 1 20  ? 186.495 142.722 164.927 1.00 53.73  ? 19  ASN C CA  1 
ATOM 1865 C C   . ASN C 1 20  ? 185.298 143.036 165.815 1.00 53.73  ? 19  ASN C C   1 
ATOM 1866 O O   . ASN C 1 20  ? 185.441 143.350 166.997 1.00 53.73  ? 19  ASN C O   1 
ATOM 1867 C CB  . ASN C 1 20  ? 186.644 141.206 164.863 1.00 53.73  ? 19  ASN C CB  1 
ATOM 1868 C CG  . ASN C 1 20  ? 186.868 140.603 166.191 1.00 53.73  ? 19  ASN C CG  1 
ATOM 1869 O OD1 . ASN C 1 20  ? 187.172 141.301 167.139 1.00 53.73  ? 19  ASN C OD1 1 
ATOM 1870 N ND2 . ASN C 1 20  ? 186.617 139.310 166.303 1.00 53.73  ? 19  ASN C ND2 1 
ATOM 1871 N N   . PHE C 1 21  ? 184.109 142.916 165.232 1.00 52.78  ? 20  PHE C N   1 
ATOM 1872 C CA  . PHE C 1 21  ? 182.871 143.359 165.852 1.00 52.78  ? 20  PHE C CA  1 
ATOM 1873 C C   . PHE C 1 21  ? 181.744 142.542 165.245 1.00 52.78  ? 20  PHE C C   1 
ATOM 1874 O O   . PHE C 1 21  ? 181.803 142.178 164.070 1.00 52.78  ? 20  PHE C O   1 
ATOM 1875 C CB  . PHE C 1 21  ? 182.708 144.849 165.596 1.00 52.78  ? 20  PHE C CB  1 
ATOM 1876 C CG  . PHE C 1 21  ? 181.770 145.560 166.517 1.00 52.78  ? 20  PHE C CG  1 
ATOM 1877 C CD1 . PHE C 1 21  ? 180.445 145.708 166.190 1.00 52.78  ? 20  PHE C CD1 1 
ATOM 1878 C CD2 . PHE C 1 21  ? 182.233 146.162 167.652 1.00 52.78  ? 20  PHE C CD2 1 
ATOM 1879 C CE1 . PHE C 1 21  ? 179.607 146.389 166.994 1.00 52.78  ? 20  PHE C CE1 1 
ATOM 1880 C CE2 . PHE C 1 21  ? 181.386 146.849 168.457 1.00 52.78  ? 20  PHE C CE2 1 
ATOM 1881 C CZ  . PHE C 1 21  ? 180.072 146.955 168.131 1.00 52.78  ? 20  PHE C CZ  1 
ATOM 1882 N N   . GLU C 1 22  ? 180.712 142.254 166.036 1.00 58.72  ? 21  GLU C N   1 
ATOM 1883 C CA  . GLU C 1 22  ? 179.820 141.158 165.685 1.00 58.72  ? 21  GLU C CA  1 
ATOM 1884 C C   . GLU C 1 22  ? 178.436 141.594 165.222 1.00 58.72  ? 21  GLU C C   1 
ATOM 1885 O O   . GLU C 1 22  ? 178.116 141.423 164.043 1.00 58.72  ? 21  GLU C O   1 
ATOM 1886 C CB  . GLU C 1 22  ? 179.692 140.230 166.889 1.00 58.72  ? 21  GLU C CB  1 
ATOM 1887 C CG  . GLU C 1 22  ? 180.728 139.157 166.903 1.00 58.72  ? 21  GLU C CG  1 
ATOM 1888 C CD  . GLU C 1 22  ? 180.512 138.167 165.795 1.00 58.72  ? 21  GLU C CD  1 
ATOM 1889 O OE1 . GLU C 1 22  ? 181.282 138.203 164.819 1.00 58.72  ? 21  GLU C OE1 1 
ATOM 1890 O OE2 . GLU C 1 22  ? 179.566 137.360 165.896 1.00 58.72  ? 21  GLU C OE2 1 
ATOM 1891 N N   . GLN C 1 23  ? 177.631 142.211 166.082 1.00 53.66  ? 22  GLN C N   1 
ATOM 1892 C CA  . GLN C 1 23  ? 176.272 142.607 165.714 1.00 53.66  ? 22  GLN C CA  1 
ATOM 1893 C C   . GLN C 1 23  ? 175.513 141.453 165.056 1.00 53.66  ? 22  GLN C C   1 
ATOM 1894 O O   . GLN C 1 23  ? 175.260 141.436 163.857 1.00 53.66  ? 22  GLN C O   1 
ATOM 1895 C CB  . GLN C 1 23  ? 176.292 143.834 164.804 1.00 53.66  ? 22  GLN C CB  1 
ATOM 1896 C CG  . GLN C 1 23  ? 176.340 145.119 165.574 1.00 53.66  ? 22  GLN C CG  1 
ATOM 1897 C CD  . GLN C 1 23  ? 176.519 146.315 164.695 1.00 53.66  ? 22  GLN C CD  1 
ATOM 1898 O OE1 . GLN C 1 23  ? 176.491 146.214 163.477 1.00 53.66  ? 22  GLN C OE1 1 
ATOM 1899 N NE2 . GLN C 1 23  ? 176.713 147.465 165.309 1.00 53.66  ? 22  GLN C NE2 1 
ATOM 1900 N N   . LYS C 1 24  ? 175.216 140.451 165.868 1.00 54.52  ? 23  LYS C N   1 
ATOM 1901 C CA  . LYS C 1 24  ? 174.449 139.291 165.436 1.00 54.52  ? 23  LYS C CA  1 
ATOM 1902 C C   . LYS C 1 24  ? 172.989 139.477 165.835 1.00 54.52  ? 23  LYS C C   1 
ATOM 1903 O O   . LYS C 1 24  ? 172.673 139.567 167.025 1.00 54.52  ? 23  LYS C O   1 
ATOM 1904 C CB  . LYS C 1 24  ? 175.038 138.025 166.051 1.00 54.52  ? 23  LYS C CB  1 
ATOM 1905 C CG  . LYS C 1 24  ? 174.097 136.856 166.143 1.00 54.52  ? 23  LYS C CG  1 
ATOM 1906 C CD  . LYS C 1 24  ? 174.866 135.573 166.417 1.00 54.52  ? 23  LYS C CD  1 
ATOM 1907 C CE  . LYS C 1 24  ? 175.989 135.796 167.416 1.00 54.52  ? 23  LYS C CE  1 
ATOM 1908 N NZ  . LYS C 1 24  ? 176.780 134.557 167.644 1.00 54.52  ? 23  LYS C NZ  1 
ATOM 1909 N N   . GLU C 1 25  ? 172.104 139.535 164.840 1.00 60.80  ? 24  GLU C N   1 
ATOM 1910 C CA  . GLU C 1 25  ? 170.705 139.896 165.041 1.00 60.80  ? 24  GLU C CA  1 
ATOM 1911 C C   . GLU C 1 25  ? 169.790 138.921 164.320 1.00 60.80  ? 24  GLU C C   1 
ATOM 1912 O O   . GLU C 1 25  ? 169.905 138.743 163.105 1.00 60.80  ? 24  GLU C O   1 
ATOM 1913 C CB  . GLU C 1 25  ? 170.427 141.304 164.535 1.00 60.80  ? 24  GLU C CB  1 
ATOM 1914 C CG  . GLU C 1 25  ? 168.966 141.648 164.505 1.00 60.80  ? 24  GLU C CG  1 
ATOM 1915 C CD  . GLU C 1 25  ? 168.403 141.832 165.886 1.00 60.80  ? 24  GLU C CD  1 
ATOM 1916 O OE1 . GLU C 1 25  ? 168.605 142.912 166.472 1.00 60.80  ? 24  GLU C OE1 1 
ATOM 1917 O OE2 . GLU C 1 25  ? 167.761 140.894 166.393 1.00 60.80  ? 24  GLU C OE2 1 
ATOM 1918 N N   . SER C 1 26  ? 168.861 138.326 165.060 1.00 65.72  ? 25  SER C N   1 
ATOM 1919 C CA  . SER C 1 26  ? 167.944 137.326 164.527 1.00 65.72  ? 25  SER C CA  1 
ATOM 1920 C C   . SER C 1 26  ? 166.521 137.711 164.882 1.00 65.72  ? 25  SER C C   1 
ATOM 1921 O O   . SER C 1 26  ? 166.152 137.716 166.060 1.00 65.72  ? 25  SER C O   1 
ATOM 1922 C CB  . SER C 1 26  ? 168.257 135.940 165.080 1.00 65.72  ? 25  SER C CB  1 
ATOM 1923 O OG  . SER C 1 26  ? 168.058 135.916 166.478 1.00 65.72  ? 25  SER C OG  1 
ATOM 1924 N N   . ASN C 1 27  ? 165.721 138.002 163.862 1.00 69.46  ? 26  ASN C N   1 
ATOM 1925 C CA  . ASN C 1 27  ? 164.307 138.290 164.045 1.00 69.46  ? 26  ASN C CA  1 
ATOM 1926 C C   . ASN C 1 27  ? 163.544 136.993 164.236 1.00 69.46  ? 26  ASN C C   1 
ATOM 1927 O O   . ASN C 1 27  ? 164.137 135.950 164.524 1.00 69.46  ? 26  ASN C O   1 
ATOM 1928 C CB  . ASN C 1 27  ? 163.748 139.049 162.849 1.00 69.46  ? 26  ASN C CB  1 
ATOM 1929 C CG  . ASN C 1 27  ? 164.323 140.434 162.723 1.00 69.46  ? 26  ASN C CG  1 
ATOM 1930 O OD1 . ASN C 1 27  ? 164.651 141.073 163.717 1.00 69.46  ? 26  ASN C OD1 1 
ATOM 1931 N ND2 . ASN C 1 27  ? 164.443 140.911 161.494 1.00 69.46  ? 26  ASN C ND2 1 
ATOM 1932 N N   . GLY C 1 28  ? 162.230 137.052 164.124 1.00 71.20  ? 27  GLY C N   1 
ATOM 1933 C CA  . GLY C 1 28  ? 161.421 135.862 164.143 1.00 71.20  ? 27  GLY C CA  1 
ATOM 1934 C C   . GLY C 1 28  ? 160.170 136.071 163.326 1.00 71.20  ? 27  GLY C C   1 
ATOM 1935 O O   . GLY C 1 28  ? 160.181 136.726 162.279 1.00 71.20  ? 27  GLY C O   1 
ATOM 1936 N N   . PRO C 1 29  ? 159.068 135.481 163.775 1.00 67.15  ? 28  PRO C N   1 
ATOM 1937 C CA  . PRO C 1 29  ? 157.750 135.895 163.290 1.00 67.15  ? 28  PRO C CA  1 
ATOM 1938 C C   . PRO C 1 29  ? 157.158 136.954 164.205 1.00 67.15  ? 28  PRO C C   1 
ATOM 1939 O O   . PRO C 1 29  ? 157.379 136.951 165.414 1.00 67.15  ? 28  PRO C O   1 
ATOM 1940 C CB  . PRO C 1 29  ? 156.957 134.586 163.339 1.00 67.15  ? 28  PRO C CB  1 
ATOM 1941 C CG  . PRO C 1 29  ? 157.582 133.826 164.465 1.00 67.15  ? 28  PRO C CG  1 
ATOM 1942 C CD  . PRO C 1 29  ? 159.010 134.244 164.570 1.00 67.15  ? 28  PRO C CD  1 
ATOM 1943 N N   . VAL C 1 30  ? 156.414 137.899 163.631 1.00 63.86  ? 29  VAL C N   1 
ATOM 1944 C CA  . VAL C 1 30  ? 155.860 139.017 164.396 1.00 63.86  ? 29  VAL C CA  1 
ATOM 1945 C C   . VAL C 1 30  ? 154.330 138.958 164.479 1.00 63.86  ? 29  VAL C C   1 
ATOM 1946 O O   . VAL C 1 30  ? 153.766 138.898 165.572 1.00 63.86  ? 29  VAL C O   1 
ATOM 1947 C CB  . VAL C 1 30  ? 156.353 140.378 163.855 1.00 63.86  ? 29  VAL C CB  1 
ATOM 1948 C CG1 . VAL C 1 30  ? 157.816 140.557 164.173 1.00 63.86  ? 29  VAL C CG1 1 
ATOM 1949 C CG2 . VAL C 1 30  ? 156.144 140.504 162.392 1.00 63.86  ? 29  VAL C CG2 1 
ATOM 1950 N N   . LYS C 1 31  ? 153.644 138.979 163.333 1.00 59.49  ? 30  LYS C N   1 
ATOM 1951 C CA  . LYS C 1 31  ? 152.194 138.772 163.257 1.00 59.49  ? 30  LYS C CA  1 
ATOM 1952 C C   . LYS C 1 31  ? 151.418 139.819 164.068 1.00 59.49  ? 30  LYS C C   1 
ATOM 1953 O O   . LYS C 1 31  ? 150.861 139.546 165.130 1.00 59.49  ? 30  LYS C O   1 
ATOM 1954 C CB  . LYS C 1 31  ? 151.824 137.347 163.688 1.00 59.49  ? 30  LYS C CB  1 
ATOM 1955 C CG  . LYS C 1 31  ? 151.919 136.337 162.556 1.00 59.49  ? 30  LYS C CG  1 
ATOM 1956 C CD  . LYS C 1 31  ? 151.540 134.947 163.011 1.00 59.49  ? 30  LYS C CD  1 
ATOM 1957 C CE  . LYS C 1 31  ? 151.354 134.032 161.817 1.00 59.49  ? 30  LYS C CE  1 
ATOM 1958 N NZ  . LYS C 1 31  ? 150.509 132.848 162.131 1.00 59.49  ? 30  LYS C NZ  1 
ATOM 1959 N N   . VAL C 1 32  ? 151.432 141.044 163.554 1.00 53.16  ? 31  VAL C N   1 
ATOM 1960 C CA  . VAL C 1 32  ? 150.601 142.127 164.068 1.00 53.16  ? 31  VAL C CA  1 
ATOM 1961 C C   . VAL C 1 32  ? 149.490 142.412 163.066 1.00 53.16  ? 31  VAL C C   1 
ATOM 1962 O O   . VAL C 1 32  ? 149.709 142.346 161.854 1.00 53.16  ? 31  VAL C O   1 
ATOM 1963 C CB  . VAL C 1 32  ? 151.441 143.390 164.349 1.00 53.16  ? 31  VAL C CB  1 
ATOM 1964 C CG1 . VAL C 1 32  ? 152.237 143.773 163.131 1.00 53.16  ? 31  VAL C CG1 1 
ATOM 1965 C CG2 . VAL C 1 32  ? 150.560 144.547 164.750 1.00 53.16  ? 31  VAL C CG2 1 
ATOM 1966 N N   . TRP C 1 33  ? 148.291 142.712 163.566 1.00 52.45  ? 32  TRP C N   1 
ATOM 1967 C CA  . TRP C 1 33  ? 147.141 142.997 162.712 1.00 52.45  ? 32  TRP C CA  1 
ATOM 1968 C C   . TRP C 1 33  ? 146.769 144.463 162.823 1.00 52.45  ? 32  TRP C C   1 
ATOM 1969 O O   . TRP C 1 33  ? 146.390 144.935 163.898 1.00 52.45  ? 32  TRP C O   1 
ATOM 1970 C CB  . TRP C 1 33  ? 145.942 142.132 163.069 1.00 52.45  ? 32  TRP C CB  1 
ATOM 1971 C CG  . TRP C 1 33  ? 145.962 140.847 162.394 1.00 52.45  ? 32  TRP C CG  1 
ATOM 1972 C CD1 . TRP C 1 33  ? 145.374 140.538 161.218 1.00 52.45  ? 32  TRP C CD1 1 
ATOM 1973 C CD2 . TRP C 1 33  ? 146.613 139.668 162.846 1.00 52.45  ? 32  TRP C CD2 1 
ATOM 1974 N NE1 . TRP C 1 33  ? 145.612 139.231 160.904 1.00 52.45  ? 32  TRP C NE1 1 
ATOM 1975 C CE2 . TRP C 1 33  ? 146.379 138.676 161.893 1.00 52.45  ? 32  TRP C CE2 1 
ATOM 1976 C CE3 . TRP C 1 33  ? 147.382 139.359 163.964 1.00 52.45  ? 32  TRP C CE3 1 
ATOM 1977 C CZ2 . TRP C 1 33  ? 146.875 137.398 162.024 1.00 52.45  ? 32  TRP C CZ2 1 
ATOM 1978 C CZ3 . TRP C 1 33  ? 147.871 138.097 164.092 1.00 52.45  ? 32  TRP C CZ3 1 
ATOM 1979 C CH2 . TRP C 1 33  ? 147.621 137.128 163.130 1.00 52.45  ? 32  TRP C CH2 1 
ATOM 1980 N N   . GLY C 1 34  ? 146.843 145.162 161.701 1.00 51.45  ? 33  GLY C N   1 
ATOM 1981 C CA  . GLY C 1 34  ? 146.602 146.584 161.677 1.00 51.45  ? 33  GLY C CA  1 
ATOM 1982 C C   . GLY C 1 34  ? 147.590 147.305 160.791 1.00 51.45  ? 33  GLY C C   1 
ATOM 1983 O O   . GLY C 1 34  ? 147.709 147.003 159.604 1.00 51.45  ? 33  GLY C O   1 
ATOM 1984 N N   . SER C 1 35  ? 148.308 148.267 161.353 1.00 50.99  ? 34  SER C N   1 
ATOM 1985 C CA  . SER C 1 35  ? 149.252 149.026 160.552 1.00 50.99  ? 34  SER C CA  1 
ATOM 1986 C C   . SER C 1 35  ? 150.453 149.374 161.407 1.00 50.99  ? 34  SER C C   1 
ATOM 1987 O O   . SER C 1 35  ? 150.349 149.471 162.631 1.00 50.99  ? 34  SER C O   1 
ATOM 1988 C CB  . SER C 1 35  ? 148.615 150.298 159.991 1.00 50.99  ? 34  SER C CB  1 
ATOM 1989 O OG  . SER C 1 35  ? 148.596 151.317 160.970 1.00 50.99  ? 34  SER C OG  1 
ATOM 1990 N N   . ILE C 1 36  ? 151.595 149.534 160.757 1.00 49.92  ? 35  ILE C N   1 
ATOM 1991 C CA  . ILE C 1 36  ? 152.781 150.088 161.383 1.00 49.92  ? 35  ILE C CA  1 
ATOM 1992 C C   . ILE C 1 36  ? 153.255 151.224 160.498 1.00 49.92  ? 35  ILE C C   1 
ATOM 1993 O O   . ILE C 1 36  ? 153.238 151.103 159.270 1.00 49.92  ? 35  ILE C O   1 
ATOM 1994 C CB  . ILE C 1 36  ? 153.879 149.028 161.569 1.00 49.92  ? 35  ILE C CB  1 
ATOM 1995 C CG1 . ILE C 1 36  ? 153.272 147.695 161.971 1.00 49.92  ? 35  ILE C CG1 1 
ATOM 1996 C CG2 . ILE C 1 36  ? 154.831 149.440 162.658 1.00 49.92  ? 35  ILE C CG2 1 
ATOM 1997 C CD1 . ILE C 1 36  ? 154.260 146.578 161.997 1.00 49.92  ? 35  ILE C CD1 1 
ATOM 1998 N N   . LYS C 1 37  ? 153.638 152.337 161.106 1.00 50.63  ? 36  LYS C N   1 
ATOM 1999 C CA  . LYS C 1 37  ? 154.151 153.463 160.343 1.00 50.63  ? 36  LYS C CA  1 
ATOM 2000 C C   . LYS C 1 37  ? 155.376 154.022 161.034 1.00 50.63  ? 36  LYS C C   1 
ATOM 2001 O O   . LYS C 1 37  ? 155.528 153.908 162.251 1.00 50.63  ? 36  LYS C O   1 
ATOM 2002 C CB  . LYS C 1 37  ? 153.112 154.563 160.172 1.00 50.63  ? 36  LYS C CB  1 
ATOM 2003 C CG  . LYS C 1 37  ? 152.657 155.173 161.464 1.00 50.63  ? 36  LYS C CG  1 
ATOM 2004 C CD  . LYS C 1 37  ? 151.487 156.092 161.238 1.00 50.63  ? 36  LYS C CD  1 
ATOM 2005 C CE  . LYS C 1 37  ? 151.787 157.099 160.161 1.00 50.63  ? 36  LYS C CE  1 
ATOM 2006 N NZ  . LYS C 1 37  ? 151.019 158.341 160.392 1.00 50.63  ? 36  LYS C NZ  1 
ATOM 2007 N N   . GLY C 1 38  ? 156.240 154.640 160.249 1.00 54.23  ? 37  GLY C N   1 
ATOM 2008 C CA  . GLY C 1 38  ? 157.495 155.093 160.791 1.00 54.23  ? 37  GLY C CA  1 
ATOM 2009 C C   . GLY C 1 38  ? 158.379 153.910 161.100 1.00 54.23  ? 37  GLY C C   1 
ATOM 2010 O O   . GLY C 1 38  ? 158.576 153.579 162.271 1.00 54.23  ? 37  GLY C O   1 
ATOM 2011 N N   . LEU C 1 39  ? 158.881 153.242 160.061 1.00 57.74  ? 38  LEU C N   1 
ATOM 2012 C CA  . LEU C 1 39  ? 159.676 152.027 160.212 1.00 57.74  ? 38  LEU C CA  1 
ATOM 2013 C C   . LEU C 1 39  ? 160.938 152.123 159.364 1.00 57.74  ? 38  LEU C C   1 
ATOM 2014 O O   . LEU C 1 39  ? 160.868 152.087 158.134 1.00 57.74  ? 38  LEU C O   1 
ATOM 2015 C CB  . LEU C 1 39  ? 158.864 150.796 159.821 1.00 57.74  ? 38  LEU C CB  1 
ATOM 2016 C CG  . LEU C 1 39  ? 159.691 149.521 159.730 1.00 57.74  ? 38  LEU C CG  1 
ATOM 2017 C CD1 . LEU C 1 39  ? 160.303 149.224 161.080 1.00 57.74  ? 38  LEU C CD1 1 
ATOM 2018 C CD2 . LEU C 1 39  ? 158.839 148.376 159.259 1.00 57.74  ? 38  LEU C CD2 1 
ATOM 2019 N N   . THR C 1 40  ? 162.092 152.191 160.012 1.00 62.22  ? 39  THR C N   1 
ATOM 2020 C CA  . THR C 1 40  ? 163.364 152.334 159.319 1.00 62.22  ? 39  THR C CA  1 
ATOM 2021 C C   . THR C 1 40  ? 164.201 151.074 159.484 1.00 62.22  ? 39  THR C C   1 
ATOM 2022 O O   . THR C 1 40  ? 164.272 150.513 160.578 1.00 62.22  ? 39  THR C O   1 
ATOM 2023 C CB  . THR C 1 40  ? 164.121 153.542 159.857 1.00 62.22  ? 39  THR C CB  1 
ATOM 2024 O OG1 . THR C 1 40  ? 164.501 153.297 161.216 1.00 62.22  ? 39  THR C OG1 1 
ATOM 2025 C CG2 . THR C 1 40  ? 163.218 154.761 159.818 1.00 62.22  ? 39  THR C CG2 1 
ATOM 2026 N N   . GLU C 1 41  ? 164.827 150.625 158.395 1.00 65.76  ? 40  GLU C N   1 
ATOM 2027 C CA  . GLU C 1 41  ? 165.675 149.430 158.424 1.00 65.76  ? 40  GLU C CA  1 
ATOM 2028 C C   . GLU C 1 41  ? 166.963 149.718 157.664 1.00 65.76  ? 40  GLU C C   1 
ATOM 2029 O O   . GLU C 1 41  ? 167.001 149.630 156.436 1.00 65.76  ? 40  GLU C O   1 
ATOM 2030 C CB  . GLU C 1 41  ? 164.964 148.218 157.839 1.00 65.76  ? 40  GLU C CB  1 
ATOM 2031 C CG  . GLU C 1 41  ? 164.050 147.500 158.811 1.00 65.76  ? 40  GLU C CG  1 
ATOM 2032 C CD  . GLU C 1 41  ? 164.798 146.612 159.771 1.00 65.76  ? 40  GLU C CD  1 
ATOM 2033 O OE1 . GLU C 1 41  ? 166.040 146.703 159.827 1.00 65.76  ? 40  GLU C OE1 1 
ATOM 2034 O OE2 . GLU C 1 41  ? 164.140 145.818 160.475 1.00 65.76  ? 40  GLU C OE2 1 
ATOM 2035 N N   . GLY C 1 42  ? 168.015 150.029 158.390 1.00 62.80  ? 41  GLY C N   1 
ATOM 2036 C CA  . GLY C 1 42  ? 169.295 150.338 157.779 1.00 62.80  ? 41  GLY C CA  1 
ATOM 2037 C C   . GLY C 1 42  ? 170.419 149.556 158.415 1.00 62.80  ? 41  GLY C C   1 
ATOM 2038 O O   . GLY C 1 42  ? 170.434 149.338 159.624 1.00 62.80  ? 41  GLY C O   1 
ATOM 2039 N N   . LEU C 1 43  ? 171.360 149.133 157.583 1.00 57.24  ? 42  LEU C N   1 
ATOM 2040 C CA  . LEU C 1 43  ? 172.501 148.357 158.060 1.00 57.24  ? 42  LEU C CA  1 
ATOM 2041 C C   . LEU C 1 43  ? 173.705 148.752 157.203 1.00 57.24  ? 42  LEU C C   1 
ATOM 2042 O O   . LEU C 1 43  ? 173.932 148.179 156.142 1.00 57.24  ? 42  LEU C O   1 
ATOM 2043 C CB  . LEU C 1 43  ? 172.169 146.875 157.975 1.00 57.24  ? 42  LEU C CB  1 
ATOM 2044 C CG  . LEU C 1 43  ? 173.094 145.689 158.190 1.00 57.24  ? 42  LEU C CG  1 
ATOM 2045 C CD1 . LEU C 1 43  ? 173.356 145.474 159.624 1.00 57.24  ? 42  LEU C CD1 1 
ATOM 2046 C CD2 . LEU C 1 43  ? 172.415 144.469 157.646 1.00 57.24  ? 42  LEU C CD2 1 
ATOM 2047 N N   . HIS C 1 44  ? 174.425 149.784 157.640 1.00 57.27  ? 43  HIS C N   1 
ATOM 2048 C CA  . HIS C 1 44  ? 175.699 150.139 157.016 1.00 57.27  ? 43  HIS C CA  1 
ATOM 2049 C C   . HIS C 1 44  ? 176.472 151.089 157.917 1.00 57.27  ? 43  HIS C C   1 
ATOM 2050 O O   . HIS C 1 44  ? 176.068 152.246 158.058 1.00 57.27  ? 43  HIS C O   1 
ATOM 2051 C CB  . HIS C 1 44  ? 175.475 150.776 155.663 1.00 57.27  ? 43  HIS C CB  1 
ATOM 2052 C CG  . HIS C 1 44  ? 174.408 151.825 155.635 1.00 57.27  ? 43  HIS C CG  1 
ATOM 2053 N ND1 . HIS C 1 44  ? 174.367 152.875 156.524 1.00 57.27  ? 43  HIS C ND1 1 
ATOM 2054 C CD2 . HIS C 1 44  ? 173.370 152.013 154.787 1.00 57.27  ? 43  HIS C CD2 1 
ATOM 2055 C CE1 . HIS C 1 44  ? 173.329 153.643 156.249 1.00 57.27  ? 43  HIS C CE1 1 
ATOM 2056 N NE2 . HIS C 1 44  ? 172.709 153.143 155.197 1.00 57.27  ? 43  HIS C NE2 1 
ATOM 2057 N N   . GLY C 1 45  ? 177.565 150.627 158.525 1.00 55.91  ? 44  GLY C N   1 
ATOM 2058 C CA  . GLY C 1 45  ? 178.414 151.579 159.221 1.00 55.91  ? 44  GLY C CA  1 
ATOM 2059 C C   . GLY C 1 45  ? 179.903 151.406 159.012 1.00 55.91  ? 44  GLY C C   1 
ATOM 2060 O O   . GLY C 1 45  ? 180.478 150.435 159.507 1.00 55.91  ? 44  GLY C O   1 
ATOM 2061 N N   . PHE C 1 46  ? 180.548 152.353 158.313 1.00 53.70  ? 45  PHE C N   1 
ATOM 2062 C CA  . PHE C 1 46  ? 182.007 152.347 158.183 1.00 53.70  ? 45  PHE C CA  1 
ATOM 2063 C C   . PHE C 1 46  ? 182.484 153.728 157.734 1.00 53.70  ? 45  PHE C C   1 
ATOM 2064 O O   . PHE C 1 46  ? 182.476 154.009 156.533 1.00 53.70  ? 45  PHE C O   1 
ATOM 2065 C CB  . PHE C 1 46  ? 182.444 151.283 157.195 1.00 53.70  ? 45  PHE C CB  1 
ATOM 2066 C CG  . PHE C 1 46  ? 183.898 150.960 157.261 1.00 53.70  ? 45  PHE C CG  1 
ATOM 2067 C CD1 . PHE C 1 46  ? 184.369 150.039 158.159 1.00 53.70  ? 45  PHE C CD1 1 
ATOM 2068 C CD2 . PHE C 1 46  ? 184.791 151.577 156.417 1.00 53.70  ? 45  PHE C CD2 1 
ATOM 2069 C CE1 . PHE C 1 46  ? 185.685 149.747 158.209 1.00 53.70  ? 45  PHE C CE1 1 
ATOM 2070 C CE2 . PHE C 1 46  ? 186.111 151.283 156.474 1.00 53.70  ? 45  PHE C CE2 1 
ATOM 2071 C CZ  . PHE C 1 46  ? 186.556 150.371 157.369 1.00 53.70  ? 45  PHE C CZ  1 
ATOM 2072 N N   . HIS C 1 47  ? 182.973 154.541 158.669 1.00 55.19  ? 46  HIS C N   1 
ATOM 2073 C CA  . HIS C 1 47  ? 183.485 155.863 158.313 1.00 55.19  ? 46  HIS C CA  1 
ATOM 2074 C C   . HIS C 1 47  ? 184.761 156.151 159.084 1.00 55.19  ? 46  HIS C C   1 
ATOM 2075 O O   . HIS C 1 47  ? 184.765 156.146 160.316 1.00 55.19  ? 46  HIS C O   1 
ATOM 2076 C CB  . HIS C 1 47  ? 182.434 156.938 158.557 1.00 55.19  ? 46  HIS C CB  1 
ATOM 2077 C CG  . HIS C 1 47  ? 181.173 156.708 157.788 1.00 55.19  ? 46  HIS C CG  1 
ATOM 2078 N ND1 . HIS C 1 47  ? 179.930 156.688 158.378 1.00 55.19  ? 46  HIS C ND1 1 
ATOM 2079 C CD2 . HIS C 1 47  ? 180.969 156.451 156.476 1.00 55.19  ? 46  HIS C CD2 1 
ATOM 2080 C CE1 . HIS C 1 47  ? 179.013 156.446 157.459 1.00 55.19  ? 46  HIS C CE1 1 
ATOM 2081 N NE2 . HIS C 1 47  ? 179.618 156.299 156.295 1.00 55.19  ? 46  HIS C NE2 1 
ATOM 2082 N N   . VAL C 1 48  ? 185.841 156.369 158.336 1.00 51.68  ? 47  VAL C N   1 
ATOM 2083 C CA  . VAL C 1 48  ? 187.217 156.330 158.818 1.00 51.68  ? 47  VAL C CA  1 
ATOM 2084 C C   . VAL C 1 48  ? 188.012 157.567 158.414 1.00 51.68  ? 47  VAL C C   1 
ATOM 2085 O O   . VAL C 1 48  ? 189.044 157.436 157.755 1.00 51.68  ? 47  VAL C O   1 
ATOM 2086 C CB  . VAL C 1 48  ? 187.928 155.052 158.352 1.00 51.68  ? 47  VAL C CB  1 
ATOM 2087 C CG1 . VAL C 1 48  ? 189.200 154.855 159.134 1.00 51.68  ? 47  VAL C CG1 1 
ATOM 2088 C CG2 . VAL C 1 48  ? 187.042 153.867 158.559 1.00 51.68  ? 47  VAL C CG2 1 
ATOM 2089 N N   . HIS C 1 49  ? 187.505 158.764 158.690 1.00 52.31  ? 48  HIS C N   1 
ATOM 2090 C CA  . HIS C 1 49  ? 188.051 160.012 158.148 1.00 52.31  ? 48  HIS C CA  1 
ATOM 2091 C C   . HIS C 1 49  ? 189.547 160.045 157.870 1.00 52.31  ? 48  HIS C C   1 
ATOM 2092 O O   . HIS C 1 49  ? 189.963 160.504 156.804 1.00 52.31  ? 48  HIS C O   1 
ATOM 2093 C CB  . HIS C 1 49  ? 187.761 161.164 159.104 1.00 52.31  ? 48  HIS C CB  1 
ATOM 2094 C CG  . HIS C 1 49  ? 186.318 161.529 159.182 1.00 52.31  ? 48  HIS C CG  1 
ATOM 2095 N ND1 . HIS C 1 49  ? 185.763 162.126 160.291 1.00 52.31  ? 48  HIS C ND1 1 
ATOM 2096 C CD2 . HIS C 1 49  ? 185.312 161.371 158.292 1.00 52.31  ? 48  HIS C CD2 1 
ATOM 2097 C CE1 . HIS C 1 49  ? 184.475 162.322 160.081 1.00 52.31  ? 48  HIS C CE1 1 
ATOM 2098 N NE2 . HIS C 1 49  ? 184.176 161.869 158.876 1.00 52.31  ? 48  HIS C NE2 1 
ATOM 2099 N N   . GLU C 1 50  ? 190.370 159.574 158.799 1.00 55.33  ? 49  GLU C N   1 
ATOM 2100 C CA  . GLU C 1 50  ? 191.811 159.659 158.607 1.00 55.33  ? 49  GLU C CA  1 
ATOM 2101 C C   . GLU C 1 50  ? 192.514 158.597 159.430 1.00 55.33  ? 49  GLU C C   1 
ATOM 2102 O O   . GLU C 1 50  ? 192.215 158.435 160.614 1.00 55.33  ? 49  GLU C O   1 
ATOM 2103 C CB  . GLU C 1 50  ? 192.322 161.040 159.000 1.00 55.33  ? 49  GLU C CB  1 
ATOM 2104 C CG  . GLU C 1 50  ? 193.672 161.383 158.452 1.00 55.33  ? 49  GLU C CG  1 
ATOM 2105 C CD  . GLU C 1 50  ? 193.585 162.200 157.191 1.00 55.33  ? 49  GLU C CD  1 
ATOM 2106 O OE1 . GLU C 1 50  ? 192.522 162.805 156.948 1.00 55.33  ? 49  GLU C OE1 1 
ATOM 2107 O OE2 . GLU C 1 50  ? 194.589 162.259 156.457 1.00 55.33  ? 49  GLU C OE2 1 
ATOM 2108 N N   . PHE C 1 51  ? 193.460 157.895 158.809 1.00 55.25  ? 50  PHE C N   1 
ATOM 2109 C CA  . PHE C 1 51  ? 194.178 156.816 159.474 1.00 55.25  ? 50  PHE C CA  1 
ATOM 2110 C C   . PHE C 1 51  ? 195.386 157.276 160.266 1.00 55.25  ? 50  PHE C C   1 
ATOM 2111 O O   . PHE C 1 51  ? 195.892 156.507 161.083 1.00 55.25  ? 50  PHE C O   1 
ATOM 2112 C CB  . PHE C 1 51  ? 194.646 155.788 158.461 1.00 55.25  ? 50  PHE C CB  1 
ATOM 2113 C CG  . PHE C 1 51  ? 193.644 154.736 158.160 1.00 55.25  ? 50  PHE C CG  1 
ATOM 2114 C CD1 . PHE C 1 51  ? 193.560 153.612 158.942 1.00 55.25  ? 50  PHE C CD1 1 
ATOM 2115 C CD2 . PHE C 1 51  ? 192.804 154.855 157.079 1.00 55.25  ? 50  PHE C CD2 1 
ATOM 2116 C CE1 . PHE C 1 51  ? 192.649 152.639 158.665 1.00 55.25  ? 50  PHE C CE1 1 
ATOM 2117 C CE2 . PHE C 1 51  ? 191.893 153.877 156.797 1.00 55.25  ? 50  PHE C CE2 1 
ATOM 2118 C CZ  . PHE C 1 51  ? 191.819 152.769 157.592 1.00 55.25  ? 50  PHE C CZ  1 
ATOM 2119 N N   . GLY C 1 52  ? 195.876 158.483 160.043 1.00 60.68  ? 51  GLY C N   1 
ATOM 2120 C CA  . GLY C 1 52  ? 197.076 158.953 160.710 1.00 60.68  ? 51  GLY C CA  1 
ATOM 2121 C C   . GLY C 1 52  ? 198.294 158.816 159.810 1.00 60.68  ? 51  GLY C C   1 
ATOM 2122 O O   . GLY C 1 52  ? 198.300 159.317 158.690 1.00 60.68  ? 51  GLY C O   1 
ATOM 2123 N N   . ASP C 1 53  ? 199.322 158.126 160.304 1.00 66.10  ? 52  ASP C N   1 
ATOM 2124 C CA  . ASP C 1 53  ? 200.525 157.920 159.507 1.00 66.10  ? 52  ASP C CA  1 
ATOM 2125 C C   . ASP C 1 53  ? 201.412 156.878 160.157 1.00 66.10  ? 52  ASP C C   1 
ATOM 2126 O O   . ASP C 1 53  ? 201.455 156.754 161.381 1.00 66.10  ? 52  ASP C O   1 
ATOM 2127 C CB  . ASP C 1 53  ? 201.308 159.216 159.333 1.00 66.10  ? 52  ASP C CB  1 
ATOM 2128 C CG  . ASP C 1 53  ? 201.394 159.996 160.601 1.00 66.10  ? 52  ASP C CG  1 
ATOM 2129 O OD1 . ASP C 1 53  ? 200.706 159.607 161.559 1.00 66.10  ? 52  ASP C OD1 1 
ATOM 2130 O OD2 . ASP C 1 53  ? 202.136 160.996 160.641 1.00 66.10  ? 52  ASP C OD2 1 
ATOM 2131 N N   . ASN C 1 54  ? 202.135 156.153 159.316 1.00 71.12  ? 53  ASN C N   1 
ATOM 2132 C CA  . ASN C 1 54  ? 203.135 155.183 159.736 1.00 71.12  ? 53  ASN C CA  1 
ATOM 2133 C C   . ASN C 1 54  ? 204.519 155.737 159.445 1.00 71.12  ? 53  ASN C C   1 
ATOM 2134 O O   . ASN C 1 54  ? 204.742 156.322 158.381 1.00 71.12  ? 53  ASN C O   1 
ATOM 2135 C CB  . ASN C 1 54  ? 202.952 153.863 158.998 1.00 71.12  ? 53  ASN C CB  1 
ATOM 2136 C CG  . ASN C 1 54  ? 201.946 152.986 159.643 1.00 71.12  ? 53  ASN C CG  1 
ATOM 2137 O OD1 . ASN C 1 54  ? 201.988 152.749 160.846 1.00 71.12  ? 53  ASN C OD1 1 
ATOM 2138 N ND2 . ASN C 1 54  ? 201.025 152.488 158.851 1.00 71.12  ? 53  ASN C ND2 1 
ATOM 2139 N N   . THR C 1 55  ? 205.451 155.527 160.369 1.00 69.50  ? 54  THR C N   1 
ATOM 2140 C CA  . THR C 1 55  ? 206.797 156.065 160.240 1.00 69.50  ? 54  THR C CA  1 
ATOM 2141 C C   . THR C 1 55  ? 207.794 154.932 160.074 1.00 69.50  ? 54  THR C C   1 
ATOM 2142 O O   . THR C 1 55  ? 207.802 153.991 160.871 1.00 69.50  ? 54  THR C O   1 
ATOM 2143 C CB  . THR C 1 55  ? 207.191 156.886 161.451 1.00 69.50  ? 54  THR C CB  1 
ATOM 2144 O OG1 . THR C 1 55  ? 207.425 155.994 162.533 1.00 69.50  ? 54  THR C OG1 1 
ATOM 2145 C CG2 . THR C 1 55  ? 206.079 157.831 161.833 1.00 69.50  ? 54  THR C CG2 1 
ATOM 2146 N N   . ALA C 1 56  ? 208.641 155.040 159.055 1.00 68.33  ? 55  ALA C N   1 
ATOM 2147 C CA  . ALA C 1 56  ? 209.755 154.119 158.860 1.00 68.33  ? 55  ALA C CA  1 
ATOM 2148 C C   . ALA C 1 56  ? 210.715 154.657 157.808 1.00 68.33  ? 55  ALA C C   1 
ATOM 2149 O O   . ALA C 1 56  ? 211.330 155.704 157.993 1.00 68.33  ? 55  ALA C O   1 
ATOM 2150 C CB  . ALA C 1 56  ? 209.258 152.750 158.463 1.00 68.33  ? 55  ALA C CB  1 
ATOM 2151 N N   . ASN C 1 87  ? 192.682 176.524 160.414 1.00 67.35  ? 86  ASN C N   1 
ATOM 2152 C CA  . ASN C 1 87  ? 192.183 177.782 159.881 1.00 67.35  ? 86  ASN C CA  1 
ATOM 2153 C C   . ASN C 1 87  ? 190.727 177.657 159.467 1.00 67.35  ? 86  ASN C C   1 
ATOM 2154 O O   . ASN C 1 87  ? 190.401 177.760 158.287 1.00 67.35  ? 86  ASN C O   1 
ATOM 2155 C CB  . ASN C 1 87  ? 193.027 178.230 158.692 1.00 67.35  ? 86  ASN C CB  1 
ATOM 2156 C CG  . ASN C 1 87  ? 192.977 179.723 158.481 1.00 67.35  ? 86  ASN C CG  1 
ATOM 2157 O OD1 . ASN C 1 87  ? 192.628 180.473 159.387 1.00 67.35  ? 86  ASN C OD1 1 
ATOM 2158 N ND2 . ASN C 1 87  ? 193.330 180.165 157.284 1.00 67.35  ? 86  ASN C ND2 1 
ATOM 2159 N N   . VAL C 1 88  ? 189.849 177.437 160.442 1.00 67.92  ? 87  VAL C N   1 
ATOM 2160 C CA  . VAL C 1 88  ? 188.427 177.230 160.190 1.00 67.92  ? 87  VAL C CA  1 
ATOM 2161 C C   . VAL C 1 88  ? 187.636 178.268 160.968 1.00 67.92  ? 87  VAL C C   1 
ATOM 2162 O O   . VAL C 1 88  ? 187.789 178.397 162.189 1.00 67.92  ? 87  VAL C O   1 
ATOM 2163 C CB  . VAL C 1 88  ? 187.981 175.795 160.525 1.00 67.92  ? 87  VAL C CB  1 
ATOM 2164 C CG1 . VAL C 1 88  ? 188.337 175.423 161.921 1.00 67.92  ? 87  VAL C CG1 1 
ATOM 2165 C CG2 . VAL C 1 88  ? 186.500 175.655 160.321 1.00 67.92  ? 87  VAL C CG2 1 
ATOM 2166 N N   . THR C 1 89  ? 186.800 179.015 160.251 1.00 71.31  ? 88  THR C N   1 
ATOM 2167 C CA  . THR C 1 89  ? 186.153 180.201 160.801 1.00 71.31  ? 88  THR C CA  1 
ATOM 2168 C C   . THR C 1 89  ? 184.776 180.374 160.176 1.00 71.31  ? 88  THR C C   1 
ATOM 2169 O O   . THR C 1 89  ? 184.656 180.628 158.974 1.00 71.31  ? 88  THR C O   1 
ATOM 2170 C CB  . THR C 1 89  ? 187.021 181.441 160.585 1.00 71.31  ? 88  THR C CB  1 
ATOM 2171 O OG1 . THR C 1 89  ? 186.305 182.612 160.991 1.00 71.31  ? 88  THR C OG1 1 
ATOM 2172 C CG2 . THR C 1 89  ? 187.493 181.564 159.145 1.00 71.31  ? 88  THR C CG2 1 
ATOM 2173 N N   . ALA C 1 90  ? 183.745 180.230 160.998 1.00 73.90  ? 89  ALA C N   1 
ATOM 2174 C CA  . ALA C 1 90  ? 182.378 180.532 160.610 1.00 73.90  ? 89  ALA C CA  1 
ATOM 2175 C C   . ALA C 1 90  ? 182.024 181.873 161.222 1.00 73.90  ? 89  ALA C C   1 
ATOM 2176 O O   . ALA C 1 90  ? 182.129 182.042 162.440 1.00 73.90  ? 89  ALA C O   1 
ATOM 2177 C CB  . ALA C 1 90  ? 181.421 179.450 161.092 1.00 73.90  ? 89  ALA C CB  1 
ATOM 2178 N N   . ASP C 1 91  ? 181.618 182.824 160.389 1.00 79.82  ? 90  ASP C N   1 
ATOM 2179 C CA  . ASP C 1 91  ? 181.667 184.211 160.833 1.00 79.82  ? 90  ASP C CA  1 
ATOM 2180 C C   . ASP C 1 91  ? 180.349 184.693 161.434 1.00 79.82  ? 90  ASP C C   1 
ATOM 2181 O O   . ASP C 1 91  ? 180.287 185.026 162.619 1.00 79.82  ? 90  ASP C O   1 
ATOM 2182 C CB  . ASP C 1 91  ? 182.097 185.106 159.669 1.00 79.82  ? 90  ASP C CB  1 
ATOM 2183 C CG  . ASP C 1 91  ? 181.902 186.570 159.965 1.00 79.82  ? 90  ASP C CG  1 
ATOM 2184 O OD1 . ASP C 1 91  ? 182.445 187.046 160.984 1.00 79.82  ? 90  ASP C OD1 1 
ATOM 2185 O OD2 . ASP C 1 91  ? 181.207 187.246 159.184 1.00 79.82  ? 90  ASP C OD2 1 
ATOM 2186 N N   . LYS C 1 92  ? 179.286 184.728 160.651 1.00 78.81  ? 91  LYS C N   1 
ATOM 2187 C CA  . LYS C 1 92  ? 178.012 185.206 161.159 1.00 78.81  ? 91  LYS C CA  1 
ATOM 2188 C C   . LYS C 1 92  ? 177.134 184.013 161.490 1.00 78.81  ? 91  LYS C C   1 
ATOM 2189 O O   . LYS C 1 92  ? 177.000 183.094 160.681 1.00 78.81  ? 91  LYS C O   1 
ATOM 2190 C CB  . LYS C 1 92  ? 177.325 186.124 160.155 1.00 78.81  ? 91  LYS C CB  1 
ATOM 2191 C CG  . LYS C 1 92  ? 178.093 187.396 159.904 1.00 78.81  ? 91  LYS C CG  1 
ATOM 2192 C CD  . LYS C 1 92  ? 178.608 187.988 161.201 1.00 78.81  ? 91  LYS C CD  1 
ATOM 2193 C CE  . LYS C 1 92  ? 179.388 189.269 160.954 1.00 78.81  ? 91  LYS C CE  1 
ATOM 2194 N NZ  . LYS C 1 92  ? 180.064 189.763 162.183 1.00 78.81  ? 91  LYS C NZ  1 
ATOM 2195 N N   . ASP C 1 93  ? 176.624 183.986 162.715 1.00 77.11  ? 92  ASP C N   1 
ATOM 2196 C CA  . ASP C 1 93  ? 175.642 183.002 163.146 1.00 77.11  ? 92  ASP C CA  1 
ATOM 2197 C C   . ASP C 1 93  ? 176.187 181.580 163.100 1.00 77.11  ? 92  ASP C C   1 
ATOM 2198 O O   . ASP C 1 93  ? 175.503 180.645 163.515 1.00 77.11  ? 92  ASP C O   1 
ATOM 2199 C CB  . ASP C 1 93  ? 174.387 183.098 162.285 1.00 77.11  ? 92  ASP C CB  1 
ATOM 2200 C CG  . ASP C 1 93  ? 173.742 184.459 162.351 1.00 77.11  ? 92  ASP C CG  1 
ATOM 2201 O OD1 . ASP C 1 93  ? 173.958 185.178 163.343 1.00 77.11  ? 92  ASP C OD1 1 
ATOM 2202 O OD2 . ASP C 1 93  ? 173.001 184.805 161.413 1.00 77.11  ? 92  ASP C OD2 1 
ATOM 2203 N N   . GLY C 1 94  ? 177.417 181.398 162.652 1.00 70.17  ? 93  GLY C N   1 
ATOM 2204 C CA  . GLY C 1 94  ? 177.860 180.088 162.235 1.00 70.17  ? 93  GLY C CA  1 
ATOM 2205 C C   . GLY C 1 94  ? 178.439 179.238 163.335 1.00 70.17  ? 93  GLY C C   1 
ATOM 2206 O O   . GLY C 1 94  ? 178.889 179.732 164.355 1.00 70.17  ? 93  GLY C O   1 
ATOM 2207 N N   . VAL C 1 95  ? 178.463 177.935 163.085 1.00 63.03  ? 94  VAL C N   1 
ATOM 2208 C CA  . VAL C 1 95  ? 178.858 176.957 164.080 1.00 63.03  ? 94  VAL C CA  1 
ATOM 2209 C C   . VAL C 1 95  ? 180.241 176.431 163.728 1.00 63.03  ? 94  VAL C C   1 
ATOM 2210 O O   . VAL C 1 95  ? 180.780 176.709 162.660 1.00 63.03  ? 94  VAL C O   1 
ATOM 2211 C CB  . VAL C 1 95  ? 177.845 175.811 164.176 1.00 63.03  ? 94  VAL C CB  1 
ATOM 2212 C CG1 . VAL C 1 95  ? 176.526 176.330 164.686 1.00 63.03  ? 94  VAL C CG1 1 
ATOM 2213 C CG2 . VAL C 1 95  ? 177.665 175.187 162.839 1.00 63.03  ? 94  VAL C CG2 1 
ATOM 2214 N N   . ALA C 1 96  ? 180.812 175.643 164.635 1.00 60.82  ? 95  ALA C N   1 
ATOM 2215 C CA  . ALA C 1 96  ? 182.166 175.133 164.441 1.00 60.82  ? 95  ALA C CA  1 
ATOM 2216 C C   . ALA C 1 96  ? 182.368 173.841 165.215 1.00 60.82  ? 95  ALA C C   1 
ATOM 2217 O O   . ALA C 1 96  ? 182.221 173.823 166.438 1.00 60.82  ? 95  ALA C O   1 
ATOM 2218 C CB  . ALA C 1 96  ? 183.199 176.169 164.876 1.00 60.82  ? 95  ALA C CB  1 
ATOM 2219 N N   . ASP C 1 97  ? 182.725 172.773 164.505 1.00 62.26  ? 96  ASP C N   1 
ATOM 2220 C CA  . ASP C 1 97  ? 183.243 171.547 165.108 1.00 62.26  ? 96  ASP C CA  1 
ATOM 2221 C C   . ASP C 1 97  ? 182.257 170.928 166.102 1.00 62.26  ? 96  ASP C C   1 
ATOM 2222 O O   . ASP C 1 97  ? 182.481 170.897 167.301 1.00 62.26  ? 96  ASP C O   1 
ATOM 2223 C CB  . ASP C 1 97  ? 184.600 171.799 165.762 1.00 62.26  ? 96  ASP C CB  1 
ATOM 2224 C CG  . ASP C 1 97  ? 185.740 171.317 164.906 1.00 62.26  ? 96  ASP C CG  1 
ATOM 2225 O OD1 . ASP C 1 97  ? 185.489 170.995 163.729 1.00 62.26  ? 96  ASP C OD1 1 
ATOM 2226 O OD2 . ASP C 1 97  ? 186.878 171.238 165.408 1.00 62.26  ? 96  ASP C OD2 1 
ATOM 2227 N N   . VAL C 1 98  ? 181.148 170.437 165.570 1.00 54.72  ? 97  VAL C N   1 
ATOM 2228 C CA  . VAL C 1 98  ? 180.212 169.657 166.365 1.00 54.72  ? 97  VAL C CA  1 
ATOM 2229 C C   . VAL C 1 98  ? 179.937 168.349 165.638 1.00 54.72  ? 97  VAL C C   1 
ATOM 2230 O O   . VAL C 1 98  ? 179.898 168.312 164.404 1.00 54.72  ? 97  VAL C O   1 
ATOM 2231 C CB  . VAL C 1 98  ? 178.916 170.448 166.641 1.00 54.72  ? 97  VAL C CB  1 
ATOM 2232 C CG1 . VAL C 1 98  ? 177.854 169.562 167.234 1.00 54.72  ? 97  VAL C CG1 1 
ATOM 2233 C CG2 . VAL C 1 98  ? 179.206 171.568 167.599 1.00 54.72  ? 97  VAL C CG2 1 
ATOM 2234 N N   . SER C 1 99  ? 179.768 167.271 166.403 1.00 52.69  ? 98  SER C N   1 
ATOM 2235 C CA  . SER C 1 99  ? 179.591 165.945 165.825 1.00 52.69  ? 98  SER C CA  1 
ATOM 2236 C C   . SER C 1 99  ? 178.747 165.096 166.760 1.00 52.69  ? 98  SER C C   1 
ATOM 2237 O O   . SER C 1 99  ? 179.135 164.880 167.906 1.00 52.69  ? 98  SER C O   1 
ATOM 2238 C CB  . SER C 1 99  ? 180.951 165.290 165.579 1.00 52.69  ? 98  SER C CB  1 
ATOM 2239 O OG  . SER C 1 99  ? 180.843 164.142 164.761 1.00 52.69  ? 98  SER C OG  1 
ATOM 2240 N N   . ILE C 1 100 ? 177.615 164.595 166.282 1.00 49.17  ? 99  ILE C N   1 
ATOM 2241 C CA  . ILE C 1 100 ? 176.690 163.832 167.112 1.00 49.17  ? 99  ILE C CA  1 
ATOM 2242 C C   . ILE C 1 100 ? 176.493 162.454 166.500 1.00 49.17  ? 99  ILE C C   1 
ATOM 2243 O O   . ILE C 1 100 ? 176.444 162.319 165.272 1.00 49.17  ? 99  ILE C O   1 
ATOM 2244 C CB  . ILE C 1 100 ? 175.333 164.556 167.260 1.00 49.17  ? 99  ILE C CB  1 
ATOM 2245 C CG1 . ILE C 1 100 ? 175.501 165.902 167.950 1.00 49.17  ? 99  ILE C CG1 1 
ATOM 2246 C CG2 . ILE C 1 100 ? 174.346 163.720 168.026 1.00 49.17  ? 99  ILE C CG2 1 
ATOM 2247 C CD1 . ILE C 1 100 ? 175.356 167.048 167.018 1.00 49.17  ? 99  ILE C CD1 1 
ATOM 2248 N N   . GLU C 1 101 ? 176.385 161.433 167.357 1.00 52.20  ? 100 GLU C N   1 
ATOM 2249 C CA  . GLU C 1 101 ? 175.964 160.096 166.951 1.00 52.20  ? 100 GLU C CA  1 
ATOM 2250 C C   . GLU C 1 101 ? 175.115 159.467 168.049 1.00 52.20  ? 100 GLU C C   1 
ATOM 2251 O O   . GLU C 1 101 ? 174.969 160.022 169.133 1.00 52.20  ? 100 GLU C O   1 
ATOM 2252 C CB  . GLU C 1 101 ? 177.158 159.201 166.619 1.00 52.20  ? 100 GLU C CB  1 
ATOM 2253 C CG  . GLU C 1 101 ? 177.995 159.695 165.467 1.00 52.20  ? 100 GLU C CG  1 
ATOM 2254 C CD  . GLU C 1 101 ? 179.300 158.972 165.369 1.00 52.20  ? 100 GLU C CD  1 
ATOM 2255 O OE1 . GLU C 1 101 ? 179.290 157.819 164.902 1.00 52.20  ? 100 GLU C OE1 1 
ATOM 2256 O OE2 . GLU C 1 101 ? 180.333 159.548 165.768 1.00 52.20  ? 100 GLU C OE2 1 
ATOM 2257 N N   . ASP C 1 102 ? 174.517 158.313 167.743 1.00 50.47  ? 101 ASP C N   1 
ATOM 2258 C CA  . ASP C 1 102 ? 173.767 157.503 168.712 1.00 50.47  ? 101 ASP C CA  1 
ATOM 2259 C C   . ASP C 1 102 ? 172.650 158.309 169.379 1.00 50.47  ? 101 ASP C C   1 
ATOM 2260 O O   . ASP C 1 102 ? 172.629 158.511 170.591 1.00 50.47  ? 101 ASP C O   1 
ATOM 2261 C CB  . ASP C 1 102 ? 174.710 156.905 169.760 1.00 50.47  ? 101 ASP C CB  1 
ATOM 2262 C CG  . ASP C 1 102 ? 174.215 155.583 170.314 1.00 50.47  ? 101 ASP C CG  1 
ATOM 2263 O OD1 . ASP C 1 102 ? 172.992 155.410 170.463 1.00 50.47  ? 101 ASP C OD1 1 
ATOM 2264 O OD2 . ASP C 1 102 ? 175.057 154.710 170.603 1.00 50.47  ? 101 ASP C OD2 1 
ATOM 2265 N N   . SER C 1 103 ? 171.706 158.755 168.557 1.00 49.06  ? 102 SER C N   1 
ATOM 2266 C CA  . SER C 1 103 ? 170.658 159.663 168.999 1.00 49.06  ? 102 SER C CA  1 
ATOM 2267 C C   . SER C 1 103 ? 169.375 159.378 168.241 1.00 49.06  ? 102 SER C C   1 
ATOM 2268 O O   . SER C 1 103 ? 169.367 159.385 167.010 1.00 49.06  ? 102 SER C O   1 
ATOM 2269 C CB  . SER C 1 103 ? 171.081 161.114 168.786 1.00 49.06  ? 102 SER C CB  1 
ATOM 2270 O OG  . SER C 1 103 ? 171.433 161.341 167.436 1.00 49.06  ? 102 SER C OG  1 
ATOM 2271 N N   . VAL C 1 104 ? 168.295 159.150 168.976 1.00 41.80  ? 103 VAL C N   1 
ATOM 2272 C CA  . VAL C 1 104 ? 167.000 158.814 168.401 1.00 41.80  ? 103 VAL C CA  1 
ATOM 2273 C C   . VAL C 1 104 ? 165.942 159.743 168.977 1.00 41.80  ? 103 VAL C C   1 
ATOM 2274 O O   . VAL C 1 104 ? 165.913 159.983 170.188 1.00 41.80  ? 103 VAL C O   1 
ATOM 2275 C CB  . VAL C 1 104 ? 166.641 157.337 168.652 1.00 41.80  ? 103 VAL C CB  1 
ATOM 2276 C CG1 . VAL C 1 104 ? 166.806 157.002 170.086 1.00 41.80  ? 103 VAL C CG1 1 
ATOM 2277 C CG2 . VAL C 1 104 ? 165.216 157.072 168.258 1.00 41.80  ? 103 VAL C CG2 1 
ATOM 2278 N N   . ILE C 1 105 ? 165.083 160.269 168.106 1.00 41.01  ? 104 ILE C N   1 
ATOM 2279 C CA  . ILE C 1 105 ? 164.012 161.185 168.481 1.00 41.01  ? 104 ILE C CA  1 
ATOM 2280 C C   . ILE C 1 105 ? 162.726 160.714 167.826 1.00 41.01  ? 104 ILE C C   1 
ATOM 2281 O O   . ILE C 1 105 ? 162.631 160.682 166.596 1.00 41.01  ? 104 ILE C O   1 
ATOM 2282 C CB  . ILE C 1 105 ? 164.321 162.628 168.061 1.00 41.01  ? 104 ILE C CB  1 
ATOM 2283 C CG1 . ILE C 1 105 ? 165.264 163.272 169.059 1.00 41.01  ? 104 ILE C CG1 1 
ATOM 2284 C CG2 . ILE C 1 105 ? 163.061 163.437 167.982 1.00 41.01  ? 104 ILE C CG2 1 
ATOM 2285 C CD1 . ILE C 1 105 ? 165.602 164.664 168.699 1.00 41.01  ? 104 ILE C CD1 1 
ATOM 2286 N N   . SER C 1 106 ? 161.738 160.367 168.638 1.00 42.02  ? 105 SER C N   1 
ATOM 2287 C CA  . SER C 1 106 ? 160.441 159.921 168.150 1.00 42.02  ? 105 SER C CA  1 
ATOM 2288 C C   . SER C 1 106 ? 159.362 160.836 168.705 1.00 42.02  ? 105 SER C C   1 
ATOM 2289 O O   . SER C 1 106 ? 159.191 160.928 169.926 1.00 42.02  ? 105 SER C O   1 
ATOM 2290 C CB  . SER C 1 106 ? 160.164 158.478 168.562 1.00 42.02  ? 105 SER C CB  1 
ATOM 2291 O OG  . SER C 1 106 ? 159.528 158.442 169.827 1.00 42.02  ? 105 SER C OG  1 
ATOM 2292 N N   . LEU C 1 107 ? 158.659 161.531 167.815 1.00 41.12  ? 106 LEU C N   1 
ATOM 2293 C CA  . LEU C 1 107 ? 157.532 162.372 168.198 1.00 41.12  ? 106 LEU C CA  1 
ATOM 2294 C C   . LEU C 1 107 ? 156.426 162.306 167.146 1.00 41.12  ? 106 LEU C C   1 
ATOM 2295 O O   . LEU C 1 107 ? 155.894 163.325 166.711 1.00 41.12  ? 106 LEU C O   1 
ATOM 2296 C CB  . LEU C 1 107 ? 158.003 163.800 168.460 1.00 41.12  ? 106 LEU C CB  1 
ATOM 2297 C CG  . LEU C 1 107 ? 158.452 164.753 167.355 1.00 41.12  ? 106 LEU C CG  1 
ATOM 2298 C CD1 . LEU C 1 107 ? 158.572 166.115 167.947 1.00 41.12  ? 106 LEU C CD1 1 
ATOM 2299 C CD2 . LEU C 1 107 ? 159.761 164.345 166.753 1.00 41.12  ? 106 LEU C CD2 1 
ATOM 2300 N N   . SER C 1 108 ? 156.069 161.098 166.708 1.00 45.88  ? 107 SER C N   1 
ATOM 2301 C CA  . SER C 1 108 ? 155.206 160.970 165.534 1.00 45.88  ? 107 SER C CA  1 
ATOM 2302 C C   . SER C 1 108 ? 153.862 161.666 165.747 1.00 45.88  ? 107 SER C C   1 
ATOM 2303 O O   . SER C 1 108 ? 153.542 162.643 165.064 1.00 45.88  ? 107 SER C O   1 
ATOM 2304 C CB  . SER C 1 108 ? 155.012 159.499 165.175 1.00 45.88  ? 107 SER C CB  1 
ATOM 2305 O OG  . SER C 1 108 ? 154.297 159.384 163.960 1.00 45.88  ? 107 SER C OG  1 
ATOM 2306 N N   . GLY C 1 109 ? 153.069 161.191 166.696 1.00 49.72  ? 108 GLY C N   1 
ATOM 2307 C CA  . GLY C 1 109 ? 151.826 161.882 166.991 1.00 49.72  ? 108 GLY C CA  1 
ATOM 2308 C C   . GLY C 1 109 ? 150.811 161.799 165.864 1.00 49.72  ? 108 GLY C C   1 
ATOM 2309 O O   . GLY C 1 109 ? 151.004 161.115 164.868 1.00 49.72  ? 108 GLY C O   1 
ATOM 2310 N N   . ASP C 1 110 ? 149.706 162.523 166.049 1.00 51.38  ? 109 ASP C N   1 
ATOM 2311 C CA  . ASP C 1 110 ? 148.616 162.550 165.079 1.00 51.38  ? 109 ASP C CA  1 
ATOM 2312 C C   . ASP C 1 110 ? 147.850 163.856 165.190 1.00 51.38  ? 109 ASP C C   1 
ATOM 2313 O O   . ASP C 1 110 ? 147.721 164.420 166.280 1.00 51.38  ? 109 ASP C O   1 
ATOM 2314 C CB  . ASP C 1 110 ? 147.653 161.381 165.275 1.00 51.38  ? 109 ASP C CB  1 
ATOM 2315 C CG  . ASP C 1 110 ? 148.113 160.133 164.587 1.00 51.38  ? 109 ASP C CG  1 
ATOM 2316 O OD1 . ASP C 1 110 ? 148.679 160.247 163.486 1.00 51.38  ? 109 ASP C OD1 1 
ATOM 2317 O OD2 . ASP C 1 110 ? 147.926 159.039 165.147 1.00 51.38  ? 109 ASP C OD2 1 
ATOM 2318 N N   . HIS C 1 111 ? 147.322 164.311 164.050 1.00 55.05  ? 110 HIS C N   1 
ATOM 2319 C CA  . HIS C 1 111 ? 146.465 165.492 163.989 1.00 55.05  ? 110 HIS C CA  1 
ATOM 2320 C C   . HIS C 1 111 ? 147.173 166.700 164.603 1.00 55.05  ? 110 HIS C C   1 
ATOM 2321 O O   . HIS C 1 111 ? 146.816 167.196 165.669 1.00 55.05  ? 110 HIS C O   1 
ATOM 2322 C CB  . HIS C 1 111 ? 145.128 165.232 164.688 1.00 55.05  ? 110 HIS C CB  1 
ATOM 2323 C CG  . HIS C 1 111 ? 144.206 164.354 163.909 1.00 55.05  ? 110 HIS C CG  1 
ATOM 2324 N ND1 . HIS C 1 111 ? 143.711 164.711 162.674 1.00 55.05  ? 110 HIS C ND1 1 
ATOM 2325 C CD2 . HIS C 1 111 ? 143.702 163.128 164.178 1.00 55.05  ? 110 HIS C CD2 1 
ATOM 2326 C CE1 . HIS C 1 111 ? 142.936 163.745 162.218 1.00 55.05  ? 110 HIS C CE1 1 
ATOM 2327 N NE2 . HIS C 1 111 ? 142.913 162.773 163.112 1.00 55.05  ? 110 HIS C NE2 1 
ATOM 2328 N N   . CYS C 1 112 ? 148.226 167.124 163.923 1.00 56.90  ? 111 CYS C N   1 
ATOM 2329 C CA  . CYS C 1 112 ? 149.134 168.106 164.480 1.00 56.90  ? 111 CYS C CA  1 
ATOM 2330 C C   . CYS C 1 112 ? 149.288 169.290 163.541 1.00 56.90  ? 111 CYS C C   1 
ATOM 2331 O O   . CYS C 1 112 ? 149.133 169.167 162.327 1.00 56.90  ? 111 CYS C O   1 
ATOM 2332 C CB  . CYS C 1 112 ? 150.497 167.480 164.764 1.00 56.90  ? 111 CYS C CB  1 
ATOM 2333 S SG  . CYS C 1 112 ? 150.554 166.534 166.292 1.00 56.90  ? 111 CYS C SG  1 
ATOM 2334 N N   . ILE C 1 113 ? 149.597 170.443 164.118 1.00 58.26  ? 112 ILE C N   1 
ATOM 2335 C CA  . ILE C 1 113 ? 149.815 171.667 163.361 1.00 58.26  ? 112 ILE C CA  1 
ATOM 2336 C C   . ILE C 1 113 ? 151.229 172.137 163.641 1.00 58.26  ? 112 ILE C C   1 
ATOM 2337 O O   . ILE C 1 113 ? 151.576 172.427 164.791 1.00 58.26  ? 112 ILE C O   1 
ATOM 2338 C CB  . ILE C 1 113 ? 148.800 172.753 163.730 1.00 58.26  ? 112 ILE C CB  1 
ATOM 2339 C CG1 . ILE C 1 113 ? 147.402 172.158 163.755 1.00 58.26  ? 112 ILE C CG1 1 
ATOM 2340 C CG2 . ILE C 1 113 ? 148.836 173.852 162.714 1.00 58.26  ? 112 ILE C CG2 1 
ATOM 2341 C CD1 . ILE C 1 113 ? 146.413 172.987 164.513 1.00 58.26  ? 112 ILE C CD1 1 
ATOM 2342 N N   . ILE C 1 114 ? 152.039 172.219 162.597 1.00 60.48  ? 113 ILE C N   1 
ATOM 2343 C CA  . ILE C 1 114 ? 153.446 172.558 162.720 1.00 60.48  ? 113 ILE C CA  1 
ATOM 2344 C C   . ILE C 1 114 ? 153.673 173.851 161.963 1.00 60.48  ? 113 ILE C C   1 
ATOM 2345 O O   . ILE C 1 114 ? 153.551 173.884 160.734 1.00 60.48  ? 113 ILE C O   1 
ATOM 2346 C CB  . ILE C 1 114 ? 154.349 171.445 162.183 1.00 60.48  ? 113 ILE C CB  1 
ATOM 2347 C CG1 . ILE C 1 114 ? 154.258 170.216 163.071 1.00 60.48  ? 113 ILE C CG1 1 
ATOM 2348 C CG2 . ILE C 1 114 ? 155.762 171.911 162.130 1.00 60.48  ? 113 ILE C CG2 1 
ATOM 2349 C CD1 . ILE C 1 114 ? 154.368 168.935 162.318 1.00 60.48  ? 113 ILE C CD1 1 
ATOM 2350 N N   . GLY C 1 115 ? 154.000 174.905 162.677 1.00 63.66  ? 114 GLY C N   1 
ATOM 2351 C CA  . GLY C 1 115 ? 154.263 176.176 162.042 1.00 63.66  ? 114 GLY C CA  1 
ATOM 2352 C C   . GLY C 1 115 ? 153.788 177.312 162.916 1.00 63.66  ? 114 GLY C C   1 
ATOM 2353 O O   . GLY C 1 115 ? 153.346 177.112 164.041 1.00 63.66  ? 114 GLY C O   1 
ATOM 2354 N N   . ARG C 1 116 ? 153.892 178.517 162.370 1.00 67.33  ? 115 ARG C N   1 
ATOM 2355 C CA  . ARG C 1 116 ? 153.474 179.702 163.097 1.00 67.33  ? 115 ARG C CA  1 
ATOM 2356 C C   . ARG C 1 116 ? 151.980 179.915 162.949 1.00 67.33  ? 115 ARG C C   1 
ATOM 2357 O O   . ARG C 1 116 ? 151.412 179.680 161.881 1.00 67.33  ? 115 ARG C O   1 
ATOM 2358 C CB  . ARG C 1 116 ? 154.212 180.936 162.599 1.00 67.33  ? 115 ARG C CB  1 
ATOM 2359 C CG  . ARG C 1 116 ? 154.094 182.104 163.550 1.00 67.33  ? 115 ARG C CG  1 
ATOM 2360 C CD  . ARG C 1 116 ? 154.564 183.368 162.904 1.00 67.33  ? 115 ARG C CD  1 
ATOM 2361 N NE  . ARG C 1 116 ? 155.993 183.325 162.640 1.00 67.33  ? 115 ARG C NE  1 
ATOM 2362 C CZ  . ARG C 1 116 ? 156.600 184.106 161.759 1.00 67.33  ? 115 ARG C CZ  1 
ATOM 2363 N NH1 . ARG C 1 116 ? 157.909 184.007 161.575 1.00 67.33  ? 115 ARG C NH1 1 
ATOM 2364 N NH2 . ARG C 1 116 ? 155.894 184.983 161.056 1.00 67.33  ? 115 ARG C NH2 1 
ATOM 2365 N N   . THR C 1 117 ? 151.348 180.370 164.029 1.00 73.93  ? 116 THR C N   1 
ATOM 2366 C CA  . THR C 1 117 ? 149.910 180.582 164.042 1.00 73.93  ? 116 THR C CA  1 
ATOM 2367 C C   . THR C 1 117 ? 149.564 181.797 164.891 1.00 73.93  ? 116 THR C C   1 
ATOM 2368 O O   . THR C 1 117 ? 150.201 182.059 165.912 1.00 73.93  ? 116 THR C O   1 
ATOM 2369 C CB  . THR C 1 117 ? 149.176 179.354 164.580 1.00 73.93  ? 116 THR C CB  1 
ATOM 2370 O OG1 . THR C 1 117 ? 149.827 178.169 164.117 1.00 73.93  ? 116 THR C OG1 1 
ATOM 2371 C CG2 . THR C 1 117 ? 147.750 179.342 164.077 1.00 73.93  ? 116 THR C CG2 1 
ATOM 2372 N N   . LEU C 1 118 ? 148.546 182.532 164.462 1.00 82.27  ? 117 LEU C N   1 
ATOM 2373 C CA  . LEU C 1 118 ? 148.025 183.659 165.219 1.00 82.27  ? 117 LEU C CA  1 
ATOM 2374 C C   . LEU C 1 118 ? 146.606 183.911 164.743 1.00 82.27  ? 117 LEU C C   1 
ATOM 2375 O O   . LEU C 1 118 ? 146.317 183.794 163.551 1.00 82.27  ? 117 LEU C O   1 
ATOM 2376 C CB  . LEU C 1 118 ? 148.896 184.904 165.041 1.00 82.27  ? 117 LEU C CB  1 
ATOM 2377 C CG  . LEU C 1 118 ? 148.293 186.272 165.355 1.00 82.27  ? 117 LEU C CG  1 
ATOM 2378 C CD1 . LEU C 1 118 ? 147.969 186.398 166.793 1.00 82.27  ? 117 LEU C CD1 1 
ATOM 2379 C CD2 . LEU C 1 118 ? 149.244 187.367 164.937 1.00 82.27  ? 117 LEU C CD2 1 
ATOM 2380 N N   . VAL C 1 119 ? 145.721 184.212 165.682 1.00 85.54  ? 118 VAL C N   1 
ATOM 2381 C CA  . VAL C 1 119 ? 144.291 184.217 165.407 1.00 85.54  ? 118 VAL C CA  1 
ATOM 2382 C C   . VAL C 1 119 ? 143.663 185.527 165.877 1.00 85.54  ? 118 VAL C C   1 
ATOM 2383 O O   . VAL C 1 119 ? 142.579 185.544 166.465 1.00 85.54  ? 118 VAL C O   1 
ATOM 2384 C CB  . VAL C 1 119 ? 143.646 182.943 165.997 1.00 85.54  ? 118 VAL C CB  1 
ATOM 2385 C CG1 . VAL C 1 119 ? 143.896 182.844 167.443 1.00 85.54  ? 118 VAL C CG1 1 
ATOM 2386 C CG2 . VAL C 1 119 ? 142.148 182.814 165.660 1.00 85.54  ? 118 VAL C CG2 1 
ATOM 2387 N N   . VAL C 1 120 ? 144.387 186.631 165.697 1.00 90.07  ? 119 VAL C N   1 
ATOM 2388 C CA  . VAL C 1 120 ? 143.803 187.948 165.920 1.00 90.07  ? 119 VAL C CA  1 
ATOM 2389 C C   . VAL C 1 120 ? 142.464 188.068 165.204 1.00 90.07  ? 119 VAL C C   1 
ATOM 2390 O O   . VAL C 1 120 ? 142.271 187.540 164.105 1.00 90.07  ? 119 VAL C O   1 
ATOM 2391 C CB  . VAL C 1 120 ? 144.786 189.040 165.465 1.00 90.07  ? 119 VAL C CB  1 
ATOM 2392 C CG1 . VAL C 1 120 ? 145.092 188.880 164.005 1.00 90.07  ? 119 VAL C CG1 1 
ATOM 2393 C CG2 . VAL C 1 120 ? 144.218 190.417 165.734 1.00 90.07  ? 119 VAL C CG2 1 
ATOM 2394 N N   . HIS C 1 121 ? 141.529 188.770 165.836 1.00 98.38  ? 120 HIS C N   1 
ATOM 2395 C CA  . HIS C 1 121 ? 140.140 188.797 165.392 1.00 98.38  ? 120 HIS C CA  1 
ATOM 2396 C C   . HIS C 1 121 ? 139.589 190.180 165.702 1.00 98.38  ? 120 HIS C C   1 
ATOM 2397 O O   . HIS C 1 121 ? 139.553 190.572 166.871 1.00 98.38  ? 120 HIS C O   1 
ATOM 2398 C CB  . HIS C 1 121 ? 139.344 187.710 166.119 1.00 98.38  ? 120 HIS C CB  1 
ATOM 2399 C CG  . HIS C 1 121 ? 138.328 187.014 165.272 1.00 98.38  ? 120 HIS C CG  1 
ATOM 2400 N ND1 . HIS C 1 121 ? 138.633 185.912 164.503 1.00 98.38  ? 120 HIS C ND1 1 
ATOM 2401 C CD2 . HIS C 1 121 ? 137.006 187.239 165.098 1.00 98.38  ? 120 HIS C CD2 1 
ATOM 2402 C CE1 . HIS C 1 121 ? 137.544 185.498 163.880 1.00 98.38  ? 120 HIS C CE1 1 
ATOM 2403 N NE2 . HIS C 1 121 ? 136.543 186.286 164.224 1.00 98.38  ? 120 HIS C NE2 1 
ATOM 2404 N N   . GLU C 1 122 ? 139.173 190.927 164.678 1.00 111.33 ? 121 GLU C N   1 
ATOM 2405 C CA  . GLU C 1 122 ? 138.792 192.313 164.916 1.00 111.33 ? 121 GLU C CA  1 
ATOM 2406 C C   . GLU C 1 122 ? 137.680 192.765 163.981 1.00 111.33 ? 121 GLU C C   1 
ATOM 2407 O O   . GLU C 1 122 ? 137.423 192.156 162.944 1.00 111.33 ? 121 GLU C O   1 
ATOM 2408 C CB  . GLU C 1 122 ? 139.996 193.243 164.787 1.00 111.33 ? 121 GLU C CB  1 
ATOM 2409 C CG  . GLU C 1 122 ? 140.637 193.560 166.117 1.00 111.33 ? 121 GLU C CG  1 
ATOM 2410 C CD  . GLU C 1 122 ? 141.883 194.393 165.976 1.00 111.33 ? 121 GLU C CD  1 
ATOM 2411 O OE1 . GLU C 1 122 ? 142.473 194.394 164.878 1.00 111.33 ? 121 GLU C OE1 1 
ATOM 2412 O OE2 . GLU C 1 122 ? 142.273 195.048 166.963 1.00 111.33 ? 121 GLU C OE2 1 
ATOM 2413 N N   . LYS C 1 123 ? 137.025 193.856 164.381 1.00 121.65 ? 122 LYS C N   1 
ATOM 2414 C CA  . LYS C 1 123 ? 135.916 194.479 163.665 1.00 121.65 ? 122 LYS C CA  1 
ATOM 2415 C C   . LYS C 1 123 ? 135.827 195.924 164.128 1.00 121.65 ? 122 LYS C C   1 
ATOM 2416 O O   . LYS C 1 123 ? 136.301 196.266 165.213 1.00 121.65 ? 122 LYS C O   1 
ATOM 2417 C CB  . LYS C 1 123 ? 134.598 193.748 163.924 1.00 121.65 ? 122 LYS C CB  1 
ATOM 2418 C CG  . LYS C 1 123 ? 134.410 193.337 165.380 1.00 121.65 ? 122 LYS C CG  1 
ATOM 2419 C CD  . LYS C 1 123 ? 133.117 192.571 165.580 1.00 121.65 ? 122 LYS C CD  1 
ATOM 2420 C CE  . LYS C 1 123 ? 132.854 192.275 167.042 1.00 121.65 ? 122 LYS C CE  1 
ATOM 2421 N NZ  . LYS C 1 123 ? 133.975 191.530 167.671 1.00 121.65 ? 122 LYS C NZ  1 
ATOM 2422 N N   . ALA C 1 124 ? 135.196 196.772 163.315 1.00 134.55 ? 123 ALA C N   1 
ATOM 2423 C CA  . ALA C 1 124 ? 135.318 198.214 163.512 1.00 134.55 ? 123 ALA C CA  1 
ATOM 2424 C C   . ALA C 1 124 ? 134.039 198.890 163.998 1.00 134.55 ? 123 ALA C C   1 
ATOM 2425 O O   . ALA C 1 124 ? 134.054 199.518 165.060 1.00 134.55 ? 123 ALA C O   1 
ATOM 2426 C CB  . ALA C 1 124 ? 135.803 198.855 162.205 1.00 134.55 ? 123 ALA C CB  1 
ATOM 2427 N N   . ASP C 1 125 ? 132.948 198.821 163.231 1.00 141.20 ? 124 ASP C N   1 
ATOM 2428 C CA  . ASP C 1 125 ? 131.589 199.203 163.637 1.00 141.20 ? 124 ASP C CA  1 
ATOM 2429 C C   . ASP C 1 125 ? 131.437 200.386 164.599 1.00 141.20 ? 124 ASP C C   1 
ATOM 2430 O O   . ASP C 1 125 ? 130.861 200.227 165.678 1.00 141.20 ? 124 ASP C O   1 
ATOM 2431 C CB  . ASP C 1 125 ? 130.867 197.984 164.228 1.00 141.20 ? 124 ASP C CB  1 
ATOM 2432 C CG  . ASP C 1 125 ? 131.745 197.158 165.142 1.00 141.20 ? 124 ASP C CG  1 
ATOM 2433 O OD1 . ASP C 1 125 ? 132.335 197.721 166.082 1.00 141.20 ? 124 ASP C OD1 1 
ATOM 2434 O OD2 . ASP C 1 125 ? 131.853 195.937 164.908 1.00 141.20 ? 124 ASP C OD2 1 
ATOM 2435 N N   . ASP C 1 126 ? 131.911 201.572 164.223 1.00 142.63 ? 125 ASP C N   1 
ATOM 2436 C CA  . ASP C 1 126 ? 131.710 202.768 165.036 1.00 142.63 ? 125 ASP C CA  1 
ATOM 2437 C C   . ASP C 1 126 ? 130.428 203.487 164.625 1.00 142.63 ? 125 ASP C C   1 
ATOM 2438 O O   . ASP C 1 126 ? 129.942 203.351 163.500 1.00 142.63 ? 125 ASP C O   1 
ATOM 2439 C CB  . ASP C 1 126 ? 132.900 203.724 164.909 1.00 142.63 ? 125 ASP C CB  1 
ATOM 2440 C CG  . ASP C 1 126 ? 132.862 204.869 165.923 1.00 142.63 ? 125 ASP C CG  1 
ATOM 2441 O OD1 . ASP C 1 126 ? 131.804 205.506 166.097 1.00 142.63 ? 125 ASP C OD1 1 
ATOM 2442 O OD2 . ASP C 1 126 ? 133.908 205.143 166.543 1.00 142.63 ? 125 ASP C OD2 1 
ATOM 2443 N N   . LEU C 1 127 ? 129.884 204.274 165.562 1.00 144.64 ? 126 LEU C N   1 
ATOM 2444 C CA  . LEU C 1 127 ? 128.667 205.041 165.289 1.00 144.64 ? 126 LEU C CA  1 
ATOM 2445 C C   . LEU C 1 127 ? 128.609 206.260 166.215 1.00 144.64 ? 126 LEU C C   1 
ATOM 2446 O O   . LEU C 1 127 ? 128.187 206.148 167.366 1.00 144.64 ? 126 LEU C O   1 
ATOM 2447 C CB  . LEU C 1 127 ? 127.428 204.160 165.422 1.00 144.64 ? 126 LEU C CB  1 
ATOM 2448 C CG  . LEU C 1 127 ? 127.027 203.487 166.737 1.00 144.64 ? 126 LEU C CG  1 
ATOM 2449 C CD1 . LEU C 1 127 ? 125.555 203.130 166.718 1.00 144.64 ? 126 LEU C CD1 1 
ATOM 2450 C CD2 . LEU C 1 127 ? 127.870 202.244 166.965 1.00 144.64 ? 126 LEU C CD2 1 
ATOM 2451 N N   . GLY C 1 128 ? 128.990 207.419 165.689 1.00 142.09 ? 127 GLY C N   1 
ATOM 2452 C CA  . GLY C 1 128 ? 129.025 208.616 166.506 1.00 142.09 ? 127 GLY C CA  1 
ATOM 2453 C C   . GLY C 1 128 ? 130.073 209.605 166.043 1.00 142.09 ? 127 GLY C C   1 
ATOM 2454 O O   . GLY C 1 128 ? 130.065 210.019 164.882 1.00 142.09 ? 127 GLY C O   1 
ATOM 2455 N N   . LYS C 1 129 ? 130.965 210.006 166.944 1.00 141.55 ? 128 LYS C N   1 
ATOM 2456 C CA  . LYS C 1 129 ? 132.102 210.866 166.631 1.00 141.55 ? 128 LYS C CA  1 
ATOM 2457 C C   . LYS C 1 129 ? 133.388 210.238 167.142 1.00 141.55 ? 128 LYS C C   1 
ATOM 2458 O O   . LYS C 1 129 ? 134.186 210.866 167.842 1.00 141.55 ? 128 LYS C O   1 
ATOM 2459 C CB  . LYS C 1 129 ? 131.930 212.262 167.217 1.00 141.55 ? 128 LYS C CB  1 
ATOM 2460 C CG  . LYS C 1 129 ? 130.713 212.998 166.715 1.00 141.55 ? 128 LYS C CG  1 
ATOM 2461 C CD  . LYS C 1 129 ? 130.990 213.684 165.396 1.00 141.55 ? 128 LYS C CD  1 
ATOM 2462 C CE  . LYS C 1 129 ? 129.787 214.493 164.942 1.00 141.55 ? 128 LYS C CE  1 
ATOM 2463 N NZ  . LYS C 1 129 ? 130.028 215.175 163.641 1.00 141.55 ? 128 LYS C NZ  1 
ATOM 2464 N N   . GLY C 1 130 ? 133.600 208.973 166.801 1.00 139.57 ? 129 GLY C N   1 
ATOM 2465 C CA  . GLY C 1 130 ? 134.733 208.226 167.309 1.00 139.57 ? 129 GLY C CA  1 
ATOM 2466 C C   . GLY C 1 130 ? 135.871 208.126 166.318 1.00 139.57 ? 129 GLY C C   1 
ATOM 2467 O O   . GLY C 1 130 ? 136.692 209.039 166.205 1.00 139.57 ? 129 GLY C O   1 
ATOM 2468 N N   . GLY C 1 131 ? 135.936 207.003 165.611 1.00 137.21 ? 130 GLY C N   1 
ATOM 2469 C CA  . GLY C 1 131 ? 136.995 206.750 164.655 1.00 137.21 ? 130 GLY C CA  1 
ATOM 2470 C C   . GLY C 1 131 ? 137.785 205.520 165.036 1.00 137.21 ? 130 GLY C C   1 
ATOM 2471 O O   . GLY C 1 131 ? 138.609 205.551 165.954 1.00 137.21 ? 130 GLY C O   1 
ATOM 2472 N N   . ASN C 1 132 ? 137.550 204.431 164.317 1.00 133.33 ? 131 ASN C N   1 
ATOM 2473 C CA  . ASN C 1 132 ? 138.005 203.105 164.711 1.00 133.33 ? 131 ASN C CA  1 
ATOM 2474 C C   . ASN C 1 132 ? 139.212 202.666 163.891 1.00 133.33 ? 131 ASN C C   1 
ATOM 2475 O O   . ASN C 1 132 ? 139.133 202.521 162.665 1.00 133.33 ? 131 ASN C O   1 
ATOM 2476 C CB  . ASN C 1 132 ? 136.845 202.118 164.623 1.00 133.33 ? 131 ASN C CB  1 
ATOM 2477 C CG  . ASN C 1 132 ? 135.947 202.395 163.449 1.00 133.33 ? 131 ASN C CG  1 
ATOM 2478 O OD1 . ASN C 1 132 ? 136.227 203.276 162.645 1.00 133.33 ? 131 ASN C OD1 1 
ATOM 2479 N ND2 . ASN C 1 132 ? 134.836 201.684 163.368 1.00 133.33 ? 131 ASN C ND2 1 
ATOM 2480 N N   . GLU C 1 133 ? 140.321 202.452 164.594 1.00 125.85 ? 132 GLU C N   1 
ATOM 2481 C CA  . GLU C 1 133 ? 141.614 202.073 164.050 1.00 125.85 ? 132 GLU C CA  1 
ATOM 2482 C C   . GLU C 1 133 ? 142.126 200.900 164.868 1.00 125.85 ? 132 GLU C C   1 
ATOM 2483 O O   . GLU C 1 133 ? 141.873 200.827 166.071 1.00 125.85 ? 132 GLU C O   1 
ATOM 2484 C CB  . GLU C 1 133 ? 142.597 203.236 164.165 1.00 125.85 ? 132 GLU C CB  1 
ATOM 2485 C CG  . GLU C 1 133 ? 143.946 203.034 163.541 1.00 125.85 ? 132 GLU C CG  1 
ATOM 2486 C CD  . GLU C 1 133 ? 143.924 203.308 162.072 1.00 125.85 ? 132 GLU C CD  1 
ATOM 2487 O OE1 . GLU C 1 133 ? 143.077 204.125 161.654 1.00 125.85 ? 132 GLU C OE1 1 
ATOM 2488 O OE2 . GLU C 1 133 ? 144.755 202.725 161.345 1.00 125.85 ? 132 GLU C OE2 1 
ATOM 2489 N N   . GLU C 1 134 ? 142.839 199.978 164.226 1.00 119.28 ? 133 GLU C N   1 
ATOM 2490 C CA  . GLU C 1 134 ? 143.369 198.831 164.953 1.00 119.28 ? 133 GLU C CA  1 
ATOM 2491 C C   . GLU C 1 134 ? 144.648 198.337 164.295 1.00 119.28 ? 133 GLU C C   1 
ATOM 2492 O O   . GLU C 1 134 ? 144.747 198.288 163.066 1.00 119.28 ? 133 GLU C O   1 
ATOM 2493 C CB  . GLU C 1 134 ? 142.341 197.703 165.044 1.00 119.28 ? 133 GLU C CB  1 
ATOM 2494 C CG  . GLU C 1 134 ? 141.720 197.288 163.728 1.00 119.28 ? 133 GLU C CG  1 
ATOM 2495 C CD  . GLU C 1 134 ? 140.363 197.919 163.497 1.00 119.28 ? 133 GLU C CD  1 
ATOM 2496 O OE1 . GLU C 1 134 ? 140.094 198.987 164.083 1.00 119.28 ? 133 GLU C OE1 1 
ATOM 2497 O OE2 . GLU C 1 134 ? 139.556 197.334 162.744 1.00 119.28 ? 133 GLU C OE2 1 
ATOM 2498 N N   . SER C 1 135 ? 145.623 197.975 165.126 1.00 109.44 ? 134 SER C N   1 
ATOM 2499 C CA  . SER C 1 135 ? 146.980 197.706 164.662 1.00 109.44 ? 134 SER C CA  1 
ATOM 2500 C C   . SER C 1 135 ? 147.560 196.383 165.143 1.00 109.44 ? 134 SER C C   1 
ATOM 2501 O O   . SER C 1 135 ? 148.327 195.761 164.408 1.00 109.44 ? 134 SER C O   1 
ATOM 2502 C CB  . SER C 1 135 ? 147.884 198.863 165.098 1.00 109.44 ? 134 SER C CB  1 
ATOM 2503 O OG  . SER C 1 135 ? 147.660 199.194 166.456 1.00 109.44 ? 134 SER C OG  1 
ATOM 2504 N N   . THR C 1 136 ? 147.254 195.972 166.370 1.00 104.31 ? 135 THR C N   1 
ATOM 2505 C CA  . THR C 1 136 ? 147.670 194.696 166.970 1.00 104.31 ? 135 THR C CA  1 
ATOM 2506 C C   . THR C 1 136 ? 149.069 194.244 166.546 1.00 104.31 ? 135 THR C C   1 
ATOM 2507 O O   . THR C 1 136 ? 149.273 193.147 166.031 1.00 104.31 ? 135 THR C O   1 
ATOM 2508 C CB  . THR C 1 136 ? 146.639 193.588 166.726 1.00 104.31 ? 135 THR C CB  1 
ATOM 2509 O OG1 . THR C 1 136 ? 147.128 192.359 167.278 1.00 104.31 ? 135 THR C OG1 1 
ATOM 2510 C CG2 . THR C 1 136 ? 146.333 193.390 165.284 1.00 104.31 ? 135 THR C CG2 1 
ATOM 2511 N N   . LYS C 1 137 ? 150.049 195.095 166.816 1.00 100.59 ? 136 LYS C N   1 
ATOM 2512 C CA  . LYS C 1 137 ? 151.428 194.720 166.549 1.00 100.59 ? 136 LYS C CA  1 
ATOM 2513 C C   . LYS C 1 137 ? 151.899 193.674 167.556 1.00 100.59 ? 136 LYS C C   1 
ATOM 2514 O O   . LYS C 1 137 ? 151.323 193.515 168.632 1.00 100.59 ? 136 LYS C O   1 
ATOM 2515 C CB  . LYS C 1 137 ? 152.329 195.953 166.595 1.00 100.59 ? 136 LYS C CB  1 
ATOM 2516 C CG  . LYS C 1 137 ? 153.140 196.125 167.869 1.00 100.59 ? 136 LYS C CG  1 
ATOM 2517 C CD  . LYS C 1 137 ? 153.986 197.387 167.789 1.00 100.59 ? 136 LYS C CD  1 
ATOM 2518 C CE  . LYS C 1 137 ? 154.951 197.511 168.953 1.00 100.59 ? 136 LYS C CE  1 
ATOM 2519 N NZ  . LYS C 1 137 ? 155.838 196.327 169.102 1.00 100.59 ? 136 LYS C NZ  1 
ATOM 2520 N N   . THR C 1 138 ? 152.961 192.947 167.199 1.00 96.51  ? 137 THR C N   1 
ATOM 2521 C CA  . THR C 1 138 ? 153.514 191.933 168.091 1.00 96.51  ? 137 THR C CA  1 
ATOM 2522 C C   . THR C 1 138 ? 154.881 192.318 168.640 1.00 96.51  ? 137 THR C C   1 
ATOM 2523 O O   . THR C 1 138 ? 155.049 192.447 169.854 1.00 96.51  ? 137 THR C O   1 
ATOM 2524 C CB  . THR C 1 138 ? 153.626 190.582 167.376 1.00 96.51  ? 137 THR C CB  1 
ATOM 2525 O OG1 . THR C 1 138 ? 154.756 190.616 166.500 1.00 96.51  ? 137 THR C OG1 1 
ATOM 2526 C CG2 . THR C 1 138 ? 152.382 190.293 166.565 1.00 96.51  ? 137 THR C CG2 1 
ATOM 2527 N N   . GLY C 1 139 ? 155.864 192.536 167.778 1.00 92.15  ? 138 GLY C N   1 
ATOM 2528 C CA  . GLY C 1 139 ? 157.209 192.752 168.264 1.00 92.15  ? 138 GLY C CA  1 
ATOM 2529 C C   . GLY C 1 139 ? 158.221 191.886 167.553 1.00 92.15  ? 138 GLY C C   1 
ATOM 2530 O O   . GLY C 1 139 ? 157.964 190.710 167.294 1.00 92.15  ? 138 GLY C O   1 
ATOM 2531 N N   . ASN C 1 140 ? 159.377 192.458 167.233 1.00 92.74  ? 139 ASN C N   1 
ATOM 2532 C CA  . ASN C 1 140 ? 160.359 191.760 166.423 1.00 92.74  ? 139 ASN C CA  1 
ATOM 2533 C C   . ASN C 1 140 ? 161.041 190.652 167.221 1.00 92.74  ? 139 ASN C C   1 
ATOM 2534 O O   . ASN C 1 140 ? 160.951 190.571 168.448 1.00 92.74  ? 139 ASN C O   1 
ATOM 2535 C CB  . ASN C 1 140 ? 161.412 192.729 165.893 1.00 92.74  ? 139 ASN C CB  1 
ATOM 2536 C CG  . ASN C 1 140 ? 160.853 193.705 164.894 1.00 92.74  ? 139 ASN C CG  1 
ATOM 2537 O OD1 . ASN C 1 140 ? 159.750 193.526 164.384 1.00 92.74  ? 139 ASN C OD1 1 
ATOM 2538 N ND2 . ASN C 1 140 ? 161.619 194.747 164.597 1.00 92.74  ? 139 ASN C ND2 1 
ATOM 2539 N N   . ALA C 1 141 ? 161.741 189.790 166.492 1.00 86.72  ? 140 ALA C N   1 
ATOM 2540 C CA  . ALA C 1 141 ? 162.556 188.757 167.104 1.00 86.72  ? 140 ALA C CA  1 
ATOM 2541 C C   . ALA C 1 141 ? 163.742 188.481 166.199 1.00 86.72  ? 140 ALA C C   1 
ATOM 2542 O O   . ALA C 1 141 ? 163.728 188.799 165.008 1.00 86.72  ? 140 ALA C O   1 
ATOM 2543 C CB  . ALA C 1 141 ? 161.758 187.475 167.351 1.00 86.72  ? 140 ALA C CB  1 
ATOM 2544 N N   . GLY C 1 142 ? 164.771 187.883 166.777 1.00 77.66  ? 141 GLY C N   1 
ATOM 2545 C CA  . GLY C 1 142 ? 165.928 187.502 165.996 1.00 77.66  ? 141 GLY C CA  1 
ATOM 2546 C C   . GLY C 1 142 ? 166.915 186.771 166.868 1.00 77.66  ? 141 GLY C C   1 
ATOM 2547 O O   . GLY C 1 142 ? 166.675 186.538 168.055 1.00 77.66  ? 141 GLY C O   1 
ATOM 2548 N N   . SER C 1 143 ? 168.049 186.420 166.260 1.00 71.79  ? 142 SER C N   1 
ATOM 2549 C CA  . SER C 1 143 ? 169.151 185.754 166.952 1.00 71.79  ? 142 SER C CA  1 
ATOM 2550 C C   . SER C 1 143 ? 168.680 184.436 167.572 1.00 71.79  ? 142 SER C C   1 
ATOM 2551 O O   . SER C 1 143 ? 168.590 184.269 168.791 1.00 71.79  ? 142 SER C O   1 
ATOM 2552 C CB  . SER C 1 143 ? 169.780 186.669 168.007 1.00 71.79  ? 142 SER C CB  1 
ATOM 2553 O OG  . SER C 1 143 ? 168.833 187.041 168.986 1.00 71.79  ? 142 SER C OG  1 
ATOM 2554 N N   . ARG C 1 144 ? 168.328 183.520 166.673 1.00 68.53  ? 143 ARG C N   1 
ATOM 2555 C CA  . ARG C 1 144 ? 168.153 182.119 167.019 1.00 68.53  ? 143 ARG C CA  1 
ATOM 2556 C C   . ARG C 1 144 ? 168.785 181.271 165.934 1.00 68.53  ? 143 ARG C C   1 
ATOM 2557 O O   . ARG C 1 144 ? 168.835 181.670 164.775 1.00 68.53  ? 143 ARG C O   1 
ATOM 2558 C CB  . ARG C 1 144 ? 166.684 181.736 167.191 1.00 68.53  ? 143 ARG C CB  1 
ATOM 2559 C CG  . ARG C 1 144 ? 165.886 181.764 165.918 1.00 68.53  ? 143 ARG C CG  1 
ATOM 2560 C CD  . ARG C 1 144 ? 164.444 181.466 166.210 1.00 68.53  ? 143 ARG C CD  1 
ATOM 2561 N NE  . ARG C 1 144 ? 163.563 182.243 165.356 1.00 68.53  ? 143 ARG C NE  1 
ATOM 2562 C CZ  . ARG C 1 144 ? 162.256 182.351 165.545 1.00 68.53  ? 143 ARG C CZ  1 
ATOM 2563 N NH1 . ARG C 1 144 ? 161.679 181.727 166.562 1.00 68.53  ? 143 ARG C NH1 1 
ATOM 2564 N NH2 . ARG C 1 144 ? 161.528 183.082 164.717 1.00 68.53  ? 143 ARG C NH2 1 
ATOM 2565 N N   . LEU C 1 145 ? 169.294 180.110 166.318 1.00 66.03  ? 144 LEU C N   1 
ATOM 2566 C CA  . LEU C 1 145 ? 169.778 179.186 165.308 1.00 66.03  ? 144 LEU C CA  1 
ATOM 2567 C C   . LEU C 1 145 ? 169.667 177.781 165.863 1.00 66.03  ? 144 LEU C C   1 
ATOM 2568 O O   . LEU C 1 145 ? 169.715 177.574 167.077 1.00 66.03  ? 144 LEU C O   1 
ATOM 2569 C CB  . LEU C 1 145 ? 171.210 179.512 164.885 1.00 66.03  ? 144 LEU C CB  1 
ATOM 2570 C CG  . LEU C 1 145 ? 171.777 178.808 163.656 1.00 66.03  ? 144 LEU C CG  1 
ATOM 2571 C CD1 . LEU C 1 145 ? 172.733 179.711 162.944 1.00 66.03  ? 144 LEU C CD1 1 
ATOM 2572 C CD2 . LEU C 1 145 ? 172.488 177.550 164.040 1.00 66.03  ? 144 LEU C CD2 1 
ATOM 2573 N N   . ALA C 1 146 ? 169.484 176.823 164.964 1.00 64.56  ? 145 ALA C N   1 
ATOM 2574 C CA  . ALA C 1 146 ? 169.302 175.428 165.333 1.00 64.56  ? 145 ALA C CA  1 
ATOM 2575 C C   . ALA C 1 146 ? 170.426 174.617 164.720 1.00 64.56  ? 145 ALA C C   1 
ATOM 2576 O O   . ALA C 1 146 ? 170.608 174.638 163.498 1.00 64.56  ? 145 ALA C O   1 
ATOM 2577 C CB  . ALA C 1 146 ? 167.949 174.914 164.856 1.00 64.56  ? 145 ALA C CB  1 
ATOM 2578 N N   . CYS C 1 147 ? 171.177 173.908 165.555 1.00 64.03  ? 146 CYS C N   1 
ATOM 2579 C CA  . CYS C 1 147 ? 172.296 173.127 165.056 1.00 64.03  ? 146 CYS C CA  1 
ATOM 2580 C C   . CYS C 1 147 ? 172.214 171.700 165.562 1.00 64.03  ? 146 CYS C C   1 
ATOM 2581 O O   . CYS C 1 147 ? 171.912 171.459 166.733 1.00 64.03  ? 146 CYS C O   1 
ATOM 2582 C CB  . CYS C 1 147 ? 173.640 173.742 165.454 1.00 64.03  ? 146 CYS C CB  1 
ATOM 2583 S SG  . CYS C 1 147 ? 174.308 173.235 167.038 1.00 64.03  ? 146 CYS C SG  1 
ATOM 2584 N N   . GLY C 1 148 ? 172.476 170.756 164.665 1.00 56.66  ? 147 GLY C N   1 
ATOM 2585 C CA  . GLY C 1 148 ? 172.605 169.369 165.058 1.00 56.66  ? 147 GLY C CA  1 
ATOM 2586 C C   . GLY C 1 148 ? 171.493 168.459 164.595 1.00 56.66  ? 147 GLY C C   1 
ATOM 2587 O O   . GLY C 1 148 ? 171.231 168.339 163.397 1.00 56.66  ? 147 GLY C O   1 
ATOM 2588 N N   . VAL C 1 149 ? 170.845 167.796 165.545 1.00 48.57  ? 148 VAL C N   1 
ATOM 2589 C CA  . VAL C 1 149 ? 169.762 166.864 165.270 1.00 48.57  ? 148 VAL C CA  1 
ATOM 2590 C C   . VAL C 1 149 ? 168.569 167.260 166.134 1.00 48.57  ? 148 VAL C C   1 
ATOM 2591 O O   . VAL C 1 149 ? 168.621 167.161 167.364 1.00 48.57  ? 148 VAL C O   1 
ATOM 2592 C CB  . VAL C 1 149 ? 170.182 165.406 165.502 1.00 48.57  ? 148 VAL C CB  1 
ATOM 2593 C CG1 . VAL C 1 149 ? 170.787 165.209 166.881 1.00 48.57  ? 148 VAL C CG1 1 
ATOM 2594 C CG2 . VAL C 1 149 ? 169.009 164.484 165.286 1.00 48.57  ? 148 VAL C CG2 1 
ATOM 2595 N N   . ILE C 1 150 ? 167.502 167.731 165.491 1.00 48.75  ? 149 ILE C N   1 
ATOM 2596 C CA  . ILE C 1 150 ? 166.440 168.425 166.203 1.00 48.75  ? 149 ILE C CA  1 
ATOM 2597 C C   . ILE C 1 150 ? 165.085 167.749 166.054 1.00 48.75  ? 149 ILE C C   1 
ATOM 2598 O O   . ILE C 1 150 ? 164.492 167.322 167.044 1.00 48.75  ? 149 ILE C O   1 
ATOM 2599 C CB  . ILE C 1 150 ? 166.350 169.883 165.750 1.00 48.75  ? 149 ILE C CB  1 
ATOM 2600 C CG1 . ILE C 1 150 ? 167.727 170.525 165.778 1.00 48.75  ? 149 ILE C CG1 1 
ATOM 2601 C CG2 . ILE C 1 150 ? 165.454 170.632 166.687 1.00 48.75  ? 149 ILE C CG2 1 
ATOM 2602 C CD1 . ILE C 1 150 ? 168.237 170.775 167.156 1.00 48.75  ? 149 ILE C CD1 1 
ATOM 2603 N N   . GLY C 1 151 ? 164.574 167.634 164.841 1.00 48.94  ? 150 GLY C N   1 
ATOM 2604 C CA  . GLY C 1 151 ? 163.167 167.301 164.741 1.00 48.94  ? 150 GLY C CA  1 
ATOM 2605 C C   . GLY C 1 151 ? 162.367 168.476 164.224 1.00 48.94  ? 150 GLY C C   1 
ATOM 2606 O O   . GLY C 1 151 ? 162.340 168.722 163.016 1.00 48.94  ? 150 GLY C O   1 
ATOM 2607 N N   . ILE C 1 152 ? 161.684 169.189 165.111 1.00 48.58  ? 151 ILE C N   1 
ATOM 2608 C CA  . ILE C 1 152 ? 161.087 170.474 164.777 1.00 48.58  ? 151 ILE C CA  1 
ATOM 2609 C C   . ILE C 1 152 ? 162.003 171.567 165.289 1.00 48.58  ? 151 ILE C C   1 
ATOM 2610 O O   . ILE C 1 152 ? 162.252 171.664 166.494 1.00 48.58  ? 151 ILE C O   1 
ATOM 2611 C CB  . ILE C 1 152 ? 159.689 170.632 165.379 1.00 48.58  ? 151 ILE C CB  1 
ATOM 2612 C CG1 . ILE C 1 152 ? 158.838 169.417 165.077 1.00 48.58  ? 151 ILE C CG1 1 
ATOM 2613 C CG2 . ILE C 1 152 ? 159.045 171.854 164.816 1.00 48.58  ? 151 ILE C CG2 1 
ATOM 2614 C CD1 . ILE C 1 152 ? 157.934 169.075 166.201 1.00 48.58  ? 151 ILE C CD1 1 
ATOM 2615 N N   . ALA C 1 153 ? 162.500 172.392 164.378 1.00 51.74  ? 152 ALA C N   1 
ATOM 2616 C CA  . ALA C 1 153 ? 163.314 173.548 164.721 1.00 51.74  ? 152 ALA C CA  1 
ATOM 2617 C C   . ALA C 1 153 ? 162.603 174.786 164.215 1.00 51.74  ? 152 ALA C C   1 
ATOM 2618 O O   . ALA C 1 153 ? 162.383 174.925 163.010 1.00 51.74  ? 152 ALA C O   1 
ATOM 2619 C CB  . ALA C 1 153 ? 164.709 173.447 164.111 1.00 51.74  ? 152 ALA C CB  1 
ATOM 2620 N N   . GLN C 1 154 ? 162.242 175.672 165.129 1.00 52.69  ? 153 GLN C N   1 
ATOM 2621 C CA  . GLN C 1 154 ? 161.528 176.881 164.763 1.00 52.69  ? 153 GLN C CA  1 
ATOM 2622 C C   . GLN C 1 154 ? 161.796 177.999 165.762 1.00 52.69  ? 153 GLN C C   1 
ATOM 2623 O O   . GLN C 1 154 ? 162.298 179.065 165.399 1.00 52.69  ? 153 GLN C O   1 
ATOM 2624 C CB  . GLN C 1 154 ? 160.036 176.600 164.671 1.00 52.69  ? 153 GLN C CB  1 
ATOM 2625 C CG  . GLN C 1 154 ? 159.468 176.015 165.930 1.00 52.69  ? 153 GLN C CG  1 
ATOM 2626 C CD  . GLN C 1 154 ? 158.115 175.395 165.717 1.00 52.69  ? 153 GLN C CD  1 
ATOM 2627 O OE1 . GLN C 1 154 ? 157.694 175.168 164.586 1.00 52.69  ? 153 GLN C OE1 1 
ATOM 2628 N NE2 . GLN C 1 154 ? 157.419 175.118 166.806 1.00 52.69  ? 153 GLN C NE2 1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   0   ?   ?   ?   A . n 
A 1 2   ALA 2   1   ?   ?   ?   A . n 
A 1 3   THR 3   2   ?   ?   ?   A . n 
A 1 4   LYS 4   3   3   LYS LYS A . n 
A 1 5   ALA 5   4   4   ALA ALA A . n 
A 1 6   VAL 6   5   5   VAL VAL A . n 
A 1 7   CYS 7   6   6   CYS CYS A . n 
A 1 8   VAL 8   7   7   VAL VAL A . n 
A 1 9   LEU 9   8   8   LEU LEU A . n 
A 1 10  LYS 10  9   9   LYS LYS A . n 
A 1 11  GLY 11  10  10  GLY GLY A . n 
A 1 12  ASP 12  11  11  ASP ASP A . n 
A 1 13  GLY 13  12  12  GLY GLY A . n 
A 1 14  PRO 14  13  13  PRO PRO A . n 
A 1 15  VAL 15  14  14  VAL VAL A . n 
A 1 16  GLN 16  15  15  GLN GLN A . n 
A 1 17  GLY 17  16  16  GLY GLY A . n 
A 1 18  ILE 18  17  17  ILE ILE A . n 
A 1 19  ILE 19  18  18  ILE ILE A . n 
A 1 20  ASN 20  19  19  ASN ASN A . n 
A 1 21  PHE 21  20  20  PHE PHE A . n 
A 1 22  GLU 22  21  21  GLU GLU A . n 
A 1 23  GLN 23  22  22  GLN GLN A . n 
A 1 24  LYS 24  23  23  LYS LYS A . n 
A 1 25  GLU 25  24  24  GLU GLU A . n 
A 1 26  SER 26  25  25  SER SER A . n 
A 1 27  ASN 27  26  26  ASN ASN A . n 
A 1 28  GLY 28  27  27  GLY GLY A . n 
A 1 29  PRO 29  28  28  PRO PRO A . n 
A 1 30  VAL 30  29  29  VAL VAL A . n 
A 1 31  LYS 31  30  30  LYS LYS A . n 
A 1 32  VAL 32  31  31  VAL VAL A . n 
A 1 33  TRP 33  32  32  TRP TRP A . n 
A 1 34  GLY 34  33  33  GLY GLY A . n 
A 1 35  SER 35  34  34  SER SER A . n 
A 1 36  ILE 36  35  35  ILE ILE A . n 
A 1 37  LYS 37  36  36  LYS LYS A . n 
A 1 38  GLY 38  37  37  GLY GLY A . n 
A 1 39  LEU 39  38  38  LEU LEU A . n 
A 1 40  THR 40  39  39  THR THR A . n 
A 1 41  GLU 41  40  40  GLU GLU A . n 
A 1 42  GLY 42  41  41  GLY GLY A . n 
A 1 43  LEU 43  42  42  LEU LEU A . n 
A 1 44  HIS 44  43  43  HIS HIS A . n 
A 1 45  GLY 45  44  44  GLY GLY A . n 
A 1 46  PHE 46  45  45  PHE PHE A . n 
A 1 47  HIS 47  46  46  HIS HIS A . n 
A 1 48  VAL 48  47  47  VAL VAL A . n 
A 1 49  HIS 49  48  48  HIS HIS A . n 
A 1 50  GLU 50  49  49  GLU GLU A . n 
A 1 51  PHE 51  50  50  PHE PHE A . n 
A 1 52  GLY 52  51  51  GLY GLY A . n 
A 1 53  ASP 53  52  52  ASP ASP A . n 
A 1 54  ASN 54  53  53  ASN ASN A . n 
A 1 55  THR 55  54  54  THR THR A . n 
A 1 56  ALA 56  55  55  ALA ALA A . n 
A 1 57  GLY 57  56  ?   ?   ?   A . n 
A 1 58  CYS 58  57  ?   ?   ?   A . n 
A 1 59  THR 59  58  ?   ?   ?   A . n 
A 1 60  SER 60  59  ?   ?   ?   A . n 
A 1 61  ALA 61  60  ?   ?   ?   A . n 
A 1 62  GLY 62  61  ?   ?   ?   A . n 
A 1 63  PRO 63  62  ?   ?   ?   A . n 
A 1 64  HIS 64  63  ?   ?   ?   A . n 
A 1 65  PHE 65  64  ?   ?   ?   A . n 
A 1 66  ASN 66  65  ?   ?   ?   A . n 
A 1 67  PRO 67  66  ?   ?   ?   A . n 
A 1 68  LEU 68  67  ?   ?   ?   A . n 
A 1 69  SER 69  68  ?   ?   ?   A . n 
A 1 70  ARG 70  69  ?   ?   ?   A . n 
A 1 71  LYS 71  70  ?   ?   ?   A . n 
A 1 72  HIS 72  71  ?   ?   ?   A . n 
A 1 73  GLY 73  72  ?   ?   ?   A . n 
A 1 74  GLY 74  73  ?   ?   ?   A . n 
A 1 75  PRO 75  74  ?   ?   ?   A . n 
A 1 76  LYS 76  75  ?   ?   ?   A . n 
A 1 77  ASP 77  76  ?   ?   ?   A . n 
A 1 78  GLU 78  77  ?   ?   ?   A . n 
A 1 79  GLU 79  78  ?   ?   ?   A . n 
A 1 80  ARG 80  79  ?   ?   ?   A . n 
A 1 81  HIS 81  80  ?   ?   ?   A . n 
A 1 82  VAL 82  81  ?   ?   ?   A . n 
A 1 83  GLY 83  82  ?   ?   ?   A . n 
A 1 84  ASP 84  83  ?   ?   ?   A . n 
A 1 85  LEU 85  84  ?   ?   ?   A . n 
A 1 86  GLY 86  85  ?   ?   ?   A . n 
A 1 87  ASN 87  86  86  ASN ASN A . n 
A 1 88  VAL 88  87  87  VAL VAL A . n 
A 1 89  THR 89  88  88  THR THR A . n 
A 1 90  ALA 90  89  89  ALA ALA A . n 
A 1 91  ASP 91  90  90  ASP ASP A . n 
A 1 92  LYS 92  91  91  LYS LYS A . n 
A 1 93  ASP 93  92  92  ASP ASP A . n 
A 1 94  GLY 94  93  93  GLY GLY A . n 
A 1 95  VAL 95  94  94  VAL VAL A . n 
A 1 96  ALA 96  95  95  ALA ALA A . n 
A 1 97  ASP 97  96  96  ASP ASP A . n 
A 1 98  VAL 98  97  97  VAL VAL A . n 
A 1 99  SER 99  98  98  SER SER A . n 
A 1 100 ILE 100 99  99  ILE ILE A . n 
A 1 101 GLU 101 100 100 GLU GLU A . n 
A 1 102 ASP 102 101 101 ASP ASP A . n 
A 1 103 SER 103 102 102 SER SER A . n 
A 1 104 VAL 104 103 103 VAL VAL A . n 
A 1 105 ILE 105 104 104 ILE ILE A . n 
A 1 106 SER 106 105 105 SER SER A . n 
A 1 107 LEU 107 106 106 LEU LEU A . n 
A 1 108 SER 108 107 107 SER SER A . n 
A 1 109 GLY 109 108 108 GLY GLY A . n 
A 1 110 ASP 110 109 109 ASP ASP A . n 
A 1 111 HIS 111 110 110 HIS HIS A . n 
A 1 112 CYS 112 111 111 CYS CYS A . n 
A 1 113 ILE 113 112 112 ILE ILE A . n 
A 1 114 ILE 114 113 113 ILE ILE A . n 
A 1 115 GLY 115 114 114 GLY GLY A . n 
A 1 116 ARG 116 115 115 ARG ARG A . n 
A 1 117 THR 117 116 116 THR THR A . n 
A 1 118 LEU 118 117 117 LEU LEU A . n 
A 1 119 VAL 119 118 118 VAL VAL A . n 
A 1 120 VAL 120 119 119 VAL VAL A . n 
A 1 121 HIS 121 120 120 HIS HIS A . n 
A 1 122 GLU 122 121 121 GLU GLU A . n 
A 1 123 LYS 123 122 122 LYS LYS A . n 
A 1 124 ALA 124 123 123 ALA ALA A . n 
A 1 125 ASP 125 124 124 ASP ASP A . n 
A 1 126 ASP 126 125 125 ASP ASP A . n 
A 1 127 LEU 127 126 126 LEU LEU A . n 
A 1 128 GLY 128 127 127 GLY GLY A . n 
A 1 129 LYS 129 128 128 LYS LYS A . n 
A 1 130 GLY 130 129 129 GLY GLY A . n 
A 1 131 GLY 131 130 130 GLY GLY A . n 
A 1 132 ASN 132 131 131 ASN ASN A . n 
A 1 133 GLU 133 132 132 GLU GLU A . n 
A 1 134 GLU 134 133 133 GLU GLU A . n 
A 1 135 SER 135 134 134 SER SER A . n 
A 1 136 THR 136 135 135 THR THR A . n 
A 1 137 LYS 137 136 136 LYS LYS A . n 
A 1 138 THR 138 137 137 THR THR A . n 
A 1 139 GLY 139 138 138 GLY GLY A . n 
A 1 140 ASN 140 139 139 ASN ASN A . n 
A 1 141 ALA 141 140 140 ALA ALA A . n 
A 1 142 GLY 142 141 141 GLY GLY A . n 
A 1 143 SER 143 142 142 SER SER A . n 
A 1 144 ARG 144 143 143 ARG ARG A . n 
A 1 145 LEU 145 144 144 LEU LEU A . n 
A 1 146 ALA 146 145 145 ALA ALA A . n 
A 1 147 CYS 147 146 146 CYS CYS A . n 
A 1 148 GLY 148 147 147 GLY GLY A . n 
A 1 149 VAL 149 148 148 VAL VAL A . n 
A 1 150 ILE 150 149 149 ILE ILE A . n 
A 1 151 GLY 151 150 150 GLY GLY A . n 
A 1 152 ILE 152 151 151 ILE ILE A . n 
A 1 153 ALA 153 152 152 ALA ALA A . n 
A 1 154 GLN 154 153 153 GLN GLN A . n 
B 1 1   MET 1   0   ?   ?   ?   B . n 
B 1 2   ALA 2   1   ?   ?   ?   B . n 
B 1 3   THR 3   2   ?   ?   ?   B . n 
B 1 4   LYS 4   3   3   LYS LYS B . n 
B 1 5   ALA 5   4   4   ALA ALA B . n 
B 1 6   VAL 6   5   5   VAL VAL B . n 
B 1 7   CYS 7   6   6   CYS CYS B . n 
B 1 8   VAL 8   7   7   VAL VAL B . n 
B 1 9   LEU 9   8   8   LEU LEU B . n 
B 1 10  LYS 10  9   9   LYS LYS B . n 
B 1 11  GLY 11  10  10  GLY GLY B . n 
B 1 12  ASP 12  11  11  ASP ASP B . n 
B 1 13  GLY 13  12  12  GLY GLY B . n 
B 1 14  PRO 14  13  13  PRO PRO B . n 
B 1 15  VAL 15  14  14  VAL VAL B . n 
B 1 16  GLN 16  15  15  GLN GLN B . n 
B 1 17  GLY 17  16  16  GLY GLY B . n 
B 1 18  ILE 18  17  17  ILE ILE B . n 
B 1 19  ILE 19  18  18  ILE ILE B . n 
B 1 20  ASN 20  19  19  ASN ASN B . n 
B 1 21  PHE 21  20  20  PHE PHE B . n 
B 1 22  GLU 22  21  21  GLU GLU B . n 
B 1 23  GLN 23  22  22  GLN GLN B . n 
B 1 24  LYS 24  23  23  LYS LYS B . n 
B 1 25  GLU 25  24  24  GLU GLU B . n 
B 1 26  SER 26  25  25  SER SER B . n 
B 1 27  ASN 27  26  26  ASN ASN B . n 
B 1 28  GLY 28  27  27  GLY GLY B . n 
B 1 29  PRO 29  28  28  PRO PRO B . n 
B 1 30  VAL 30  29  29  VAL VAL B . n 
B 1 31  LYS 31  30  30  LYS LYS B . n 
B 1 32  VAL 32  31  31  VAL VAL B . n 
B 1 33  TRP 33  32  32  TRP TRP B . n 
B 1 34  GLY 34  33  33  GLY GLY B . n 
B 1 35  SER 35  34  34  SER SER B . n 
B 1 36  ILE 36  35  35  ILE ILE B . n 
B 1 37  LYS 37  36  36  LYS LYS B . n 
B 1 38  GLY 38  37  37  GLY GLY B . n 
B 1 39  LEU 39  38  38  LEU LEU B . n 
B 1 40  THR 40  39  39  THR THR B . n 
B 1 41  GLU 41  40  40  GLU GLU B . n 
B 1 42  GLY 42  41  41  GLY GLY B . n 
B 1 43  LEU 43  42  42  LEU LEU B . n 
B 1 44  HIS 44  43  43  HIS HIS B . n 
B 1 45  GLY 45  44  44  GLY GLY B . n 
B 1 46  PHE 46  45  45  PHE PHE B . n 
B 1 47  HIS 47  46  46  HIS HIS B . n 
B 1 48  VAL 48  47  47  VAL VAL B . n 
B 1 49  HIS 49  48  48  HIS HIS B . n 
B 1 50  GLU 50  49  49  GLU GLU B . n 
B 1 51  PHE 51  50  50  PHE PHE B . n 
B 1 52  GLY 52  51  51  GLY GLY B . n 
B 1 53  ASP 53  52  52  ASP ASP B . n 
B 1 54  ASN 54  53  53  ASN ASN B . n 
B 1 55  THR 55  54  54  THR THR B . n 
B 1 56  ALA 56  55  55  ALA ALA B . n 
B 1 57  GLY 57  56  ?   ?   ?   B . n 
B 1 58  CYS 58  57  ?   ?   ?   B . n 
B 1 59  THR 59  58  ?   ?   ?   B . n 
B 1 60  SER 60  59  ?   ?   ?   B . n 
B 1 61  ALA 61  60  ?   ?   ?   B . n 
B 1 62  GLY 62  61  ?   ?   ?   B . n 
B 1 63  PRO 63  62  ?   ?   ?   B . n 
B 1 64  HIS 64  63  ?   ?   ?   B . n 
B 1 65  PHE 65  64  ?   ?   ?   B . n 
B 1 66  ASN 66  65  ?   ?   ?   B . n 
B 1 67  PRO 67  66  ?   ?   ?   B . n 
B 1 68  LEU 68  67  ?   ?   ?   B . n 
B 1 69  SER 69  68  ?   ?   ?   B . n 
B 1 70  ARG 70  69  ?   ?   ?   B . n 
B 1 71  LYS 71  70  ?   ?   ?   B . n 
B 1 72  HIS 72  71  ?   ?   ?   B . n 
B 1 73  GLY 73  72  ?   ?   ?   B . n 
B 1 74  GLY 74  73  ?   ?   ?   B . n 
B 1 75  PRO 75  74  ?   ?   ?   B . n 
B 1 76  LYS 76  75  ?   ?   ?   B . n 
B 1 77  ASP 77  76  ?   ?   ?   B . n 
B 1 78  GLU 78  77  ?   ?   ?   B . n 
B 1 79  GLU 79  78  ?   ?   ?   B . n 
B 1 80  ARG 80  79  ?   ?   ?   B . n 
B 1 81  HIS 81  80  ?   ?   ?   B . n 
B 1 82  VAL 82  81  ?   ?   ?   B . n 
B 1 83  GLY 83  82  ?   ?   ?   B . n 
B 1 84  ASP 84  83  ?   ?   ?   B . n 
B 1 85  LEU 85  84  ?   ?   ?   B . n 
B 1 86  GLY 86  85  ?   ?   ?   B . n 
B 1 87  ASN 87  86  86  ASN ASN B . n 
B 1 88  VAL 88  87  87  VAL VAL B . n 
B 1 89  THR 89  88  88  THR THR B . n 
B 1 90  ALA 90  89  89  ALA ALA B . n 
B 1 91  ASP 91  90  90  ASP ASP B . n 
B 1 92  LYS 92  91  91  LYS LYS B . n 
B 1 93  ASP 93  92  92  ASP ASP B . n 
B 1 94  GLY 94  93  93  GLY GLY B . n 
B 1 95  VAL 95  94  94  VAL VAL B . n 
B 1 96  ALA 96  95  95  ALA ALA B . n 
B 1 97  ASP 97  96  96  ASP ASP B . n 
B 1 98  VAL 98  97  97  VAL VAL B . n 
B 1 99  SER 99  98  98  SER SER B . n 
B 1 100 ILE 100 99  99  ILE ILE B . n 
B 1 101 GLU 101 100 100 GLU GLU B . n 
B 1 102 ASP 102 101 101 ASP ASP B . n 
B 1 103 SER 103 102 102 SER SER B . n 
B 1 104 VAL 104 103 103 VAL VAL B . n 
B 1 105 ILE 105 104 104 ILE ILE B . n 
B 1 106 SER 106 105 105 SER SER B . n 
B 1 107 LEU 107 106 106 LEU LEU B . n 
B 1 108 SER 108 107 107 SER SER B . n 
B 1 109 GLY 109 108 108 GLY GLY B . n 
B 1 110 ASP 110 109 109 ASP ASP B . n 
B 1 111 HIS 111 110 110 HIS HIS B . n 
B 1 112 CYS 112 111 111 CYS CYS B . n 
B 1 113 ILE 113 112 112 ILE ILE B . n 
B 1 114 ILE 114 113 113 ILE ILE B . n 
B 1 115 GLY 115 114 114 GLY GLY B . n 
B 1 116 ARG 116 115 115 ARG ARG B . n 
B 1 117 THR 117 116 116 THR THR B . n 
B 1 118 LEU 118 117 117 LEU LEU B . n 
B 1 119 VAL 119 118 118 VAL VAL B . n 
B 1 120 VAL 120 119 119 VAL VAL B . n 
B 1 121 HIS 121 120 120 HIS HIS B . n 
B 1 122 GLU 122 121 121 GLU GLU B . n 
B 1 123 LYS 123 122 122 LYS LYS B . n 
B 1 124 ALA 124 123 123 ALA ALA B . n 
B 1 125 ASP 125 124 124 ASP ASP B . n 
B 1 126 ASP 126 125 125 ASP ASP B . n 
B 1 127 LEU 127 126 126 LEU LEU B . n 
B 1 128 GLY 128 127 127 GLY GLY B . n 
B 1 129 LYS 129 128 128 LYS LYS B . n 
B 1 130 GLY 130 129 129 GLY GLY B . n 
B 1 131 GLY 131 130 130 GLY GLY B . n 
B 1 132 ASN 132 131 131 ASN ASN B . n 
B 1 133 GLU 133 132 132 GLU GLU B . n 
B 1 134 GLU 134 133 133 GLU GLU B . n 
B 1 135 SER 135 134 134 SER SER B . n 
B 1 136 THR 136 135 135 THR THR B . n 
B 1 137 LYS 137 136 136 LYS LYS B . n 
B 1 138 THR 138 137 137 THR THR B . n 
B 1 139 GLY 139 138 138 GLY GLY B . n 
B 1 140 ASN 140 139 139 ASN ASN B . n 
B 1 141 ALA 141 140 140 ALA ALA B . n 
B 1 142 GLY 142 141 141 GLY GLY B . n 
B 1 143 SER 143 142 142 SER SER B . n 
B 1 144 ARG 144 143 143 ARG ARG B . n 
B 1 145 LEU 145 144 144 LEU LEU B . n 
B 1 146 ALA 146 145 145 ALA ALA B . n 
B 1 147 CYS 147 146 146 CYS CYS B . n 
B 1 148 GLY 148 147 147 GLY GLY B . n 
B 1 149 VAL 149 148 148 VAL VAL B . n 
B 1 150 ILE 150 149 149 ILE ILE B . n 
B 1 151 GLY 151 150 150 GLY GLY B . n 
B 1 152 ILE 152 151 151 ILE ILE B . n 
B 1 153 ALA 153 152 152 ALA ALA B . n 
B 1 154 GLN 154 153 153 GLN GLN B . n 
C 1 1   MET 1   0   ?   ?   ?   C . n 
C 1 2   ALA 2   1   ?   ?   ?   C . n 
C 1 3   THR 3   2   ?   ?   ?   C . n 
C 1 4   LYS 4   3   3   LYS LYS C . n 
C 1 5   ALA 5   4   4   ALA ALA C . n 
C 1 6   VAL 6   5   5   VAL VAL C . n 
C 1 7   CYS 7   6   6   CYS CYS C . n 
C 1 8   VAL 8   7   7   VAL VAL C . n 
C 1 9   LEU 9   8   8   LEU LEU C . n 
C 1 10  LYS 10  9   9   LYS LYS C . n 
C 1 11  GLY 11  10  10  GLY GLY C . n 
C 1 12  ASP 12  11  11  ASP ASP C . n 
C 1 13  GLY 13  12  12  GLY GLY C . n 
C 1 14  PRO 14  13  13  PRO PRO C . n 
C 1 15  VAL 15  14  14  VAL VAL C . n 
C 1 16  GLN 16  15  15  GLN GLN C . n 
C 1 17  GLY 17  16  16  GLY GLY C . n 
C 1 18  ILE 18  17  17  ILE ILE C . n 
C 1 19  ILE 19  18  18  ILE ILE C . n 
C 1 20  ASN 20  19  19  ASN ASN C . n 
C 1 21  PHE 21  20  20  PHE PHE C . n 
C 1 22  GLU 22  21  21  GLU GLU C . n 
C 1 23  GLN 23  22  22  GLN GLN C . n 
C 1 24  LYS 24  23  23  LYS LYS C . n 
C 1 25  GLU 25  24  24  GLU GLU C . n 
C 1 26  SER 26  25  25  SER SER C . n 
C 1 27  ASN 27  26  26  ASN ASN C . n 
C 1 28  GLY 28  27  27  GLY GLY C . n 
C 1 29  PRO 29  28  28  PRO PRO C . n 
C 1 30  VAL 30  29  29  VAL VAL C . n 
C 1 31  LYS 31  30  30  LYS LYS C . n 
C 1 32  VAL 32  31  31  VAL VAL C . n 
C 1 33  TRP 33  32  32  TRP TRP C . n 
C 1 34  GLY 34  33  33  GLY GLY C . n 
C 1 35  SER 35  34  34  SER SER C . n 
C 1 36  ILE 36  35  35  ILE ILE C . n 
C 1 37  LYS 37  36  36  LYS LYS C . n 
C 1 38  GLY 38  37  37  GLY GLY C . n 
C 1 39  LEU 39  38  38  LEU LEU C . n 
C 1 40  THR 40  39  39  THR THR C . n 
C 1 41  GLU 41  40  40  GLU GLU C . n 
C 1 42  GLY 42  41  41  GLY GLY C . n 
C 1 43  LEU 43  42  42  LEU LEU C . n 
C 1 44  HIS 44  43  43  HIS HIS C . n 
C 1 45  GLY 45  44  44  GLY GLY C . n 
C 1 46  PHE 46  45  45  PHE PHE C . n 
C 1 47  HIS 47  46  46  HIS HIS C . n 
C 1 48  VAL 48  47  47  VAL VAL C . n 
C 1 49  HIS 49  48  48  HIS HIS C . n 
C 1 50  GLU 50  49  49  GLU GLU C . n 
C 1 51  PHE 51  50  50  PHE PHE C . n 
C 1 52  GLY 52  51  51  GLY GLY C . n 
C 1 53  ASP 53  52  52  ASP ASP C . n 
C 1 54  ASN 54  53  53  ASN ASN C . n 
C 1 55  THR 55  54  54  THR THR C . n 
C 1 56  ALA 56  55  55  ALA ALA C . n 
C 1 57  GLY 57  56  ?   ?   ?   C . n 
C 1 58  CYS 58  57  ?   ?   ?   C . n 
C 1 59  THR 59  58  ?   ?   ?   C . n 
C 1 60  SER 60  59  ?   ?   ?   C . n 
C 1 61  ALA 61  60  ?   ?   ?   C . n 
C 1 62  GLY 62  61  ?   ?   ?   C . n 
C 1 63  PRO 63  62  ?   ?   ?   C . n 
C 1 64  HIS 64  63  ?   ?   ?   C . n 
C 1 65  PHE 65  64  ?   ?   ?   C . n 
C 1 66  ASN 66  65  ?   ?   ?   C . n 
C 1 67  PRO 67  66  ?   ?   ?   C . n 
C 1 68  LEU 68  67  ?   ?   ?   C . n 
C 1 69  SER 69  68  ?   ?   ?   C . n 
C 1 70  ARG 70  69  ?   ?   ?   C . n 
C 1 71  LYS 71  70  ?   ?   ?   C . n 
C 1 72  HIS 72  71  ?   ?   ?   C . n 
C 1 73  GLY 73  72  ?   ?   ?   C . n 
C 1 74  GLY 74  73  ?   ?   ?   C . n 
C 1 75  PRO 75  74  ?   ?   ?   C . n 
C 1 76  LYS 76  75  ?   ?   ?   C . n 
C 1 77  ASP 77  76  ?   ?   ?   C . n 
C 1 78  GLU 78  77  ?   ?   ?   C . n 
C 1 79  GLU 79  78  ?   ?   ?   C . n 
C 1 80  ARG 80  79  ?   ?   ?   C . n 
C 1 81  HIS 81  80  ?   ?   ?   C . n 
C 1 82  VAL 82  81  ?   ?   ?   C . n 
C 1 83  GLY 83  82  ?   ?   ?   C . n 
C 1 84  ASP 84  83  ?   ?   ?   C . n 
C 1 85  LEU 85  84  ?   ?   ?   C . n 
C 1 86  GLY 86  85  ?   ?   ?   C . n 
C 1 87  ASN 87  86  86  ASN ASN C . n 
C 1 88  VAL 88  87  87  VAL VAL C . n 
C 1 89  THR 89  88  88  THR THR C . n 
C 1 90  ALA 90  89  89  ALA ALA C . n 
C 1 91  ASP 91  90  90  ASP ASP C . n 
C 1 92  LYS 92  91  91  LYS LYS C . n 
C 1 93  ASP 93  92  92  ASP ASP C . n 
C 1 94  GLY 94  93  93  GLY GLY C . n 
C 1 95  VAL 95  94  94  VAL VAL C . n 
C 1 96  ALA 96  95  95  ALA ALA C . n 
C 1 97  ASP 97  96  96  ASP ASP C . n 
C 1 98  VAL 98  97  97  VAL VAL C . n 
C 1 99  SER 99  98  98  SER SER C . n 
C 1 100 ILE 100 99  99  ILE ILE C . n 
C 1 101 GLU 101 100 100 GLU GLU C . n 
C 1 102 ASP 102 101 101 ASP ASP C . n 
C 1 103 SER 103 102 102 SER SER C . n 
C 1 104 VAL 104 103 103 VAL VAL C . n 
C 1 105 ILE 105 104 104 ILE ILE C . n 
C 1 106 SER 106 105 105 SER SER C . n 
C 1 107 LEU 107 106 106 LEU LEU C . n 
C 1 108 SER 108 107 107 SER SER C . n 
C 1 109 GLY 109 108 108 GLY GLY C . n 
C 1 110 ASP 110 109 109 ASP ASP C . n 
C 1 111 HIS 111 110 110 HIS HIS C . n 
C 1 112 CYS 112 111 111 CYS CYS C . n 
C 1 113 ILE 113 112 112 ILE ILE C . n 
C 1 114 ILE 114 113 113 ILE ILE C . n 
C 1 115 GLY 115 114 114 GLY GLY C . n 
C 1 116 ARG 116 115 115 ARG ARG C . n 
C 1 117 THR 117 116 116 THR THR C . n 
C 1 118 LEU 118 117 117 LEU LEU C . n 
C 1 119 VAL 119 118 118 VAL VAL C . n 
C 1 120 VAL 120 119 119 VAL VAL C . n 
C 1 121 HIS 121 120 120 HIS HIS C . n 
C 1 122 GLU 122 121 121 GLU GLU C . n 
C 1 123 LYS 123 122 122 LYS LYS C . n 
C 1 124 ALA 124 123 123 ALA ALA C . n 
C 1 125 ASP 125 124 124 ASP ASP C . n 
C 1 126 ASP 126 125 125 ASP ASP C . n 
C 1 127 LEU 127 126 126 LEU LEU C . n 
C 1 128 GLY 128 127 127 GLY GLY C . n 
C 1 129 LYS 129 128 128 LYS LYS C . n 
C 1 130 GLY 130 129 129 GLY GLY C . n 
C 1 131 GLY 131 130 130 GLY GLY C . n 
C 1 132 ASN 132 131 131 ASN ASN C . n 
C 1 133 GLU 133 132 132 GLU GLU C . n 
C 1 134 GLU 134 133 133 GLU GLU C . n 
C 1 135 SER 135 134 134 SER SER C . n 
C 1 136 THR 136 135 135 THR THR C . n 
C 1 137 LYS 137 136 136 LYS LYS C . n 
C 1 138 THR 138 137 137 THR THR C . n 
C 1 139 GLY 139 138 138 GLY GLY C . n 
C 1 140 ASN 140 139 139 ASN ASN C . n 
C 1 141 ALA 141 140 140 ALA ALA C . n 
C 1 142 GLY 142 141 141 GLY GLY C . n 
C 1 143 SER 143 142 142 SER SER C . n 
C 1 144 ARG 144 143 143 ARG ARG C . n 
C 1 145 LEU 145 144 144 LEU LEU C . n 
C 1 146 ALA 146 145 145 ALA ALA C . n 
C 1 147 CYS 147 146 146 CYS CYS C . n 
C 1 148 GLY 148 147 147 GLY GLY C . n 
C 1 149 VAL 149 148 148 VAL VAL C . n 
C 1 150 ILE 150 149 149 ILE ILE C . n 
C 1 151 GLY 151 150 150 GLY GLY C . n 
C 1 152 ILE 152 151 151 ILE ILE C . n 
C 1 153 ALA 153 152 152 ALA ALA C . n 
C 1 154 GLN 154 153 153 GLN GLN C . n 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 liangyi@whu.edu.cn Yi   Liang ? 'principal investigator/group leader' 0000-0002-7349-8300 
4 liulab@sioc.ac.cn  Cong Liu   ? 'principal investigator/group leader' 0000-0003-3425-6672 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2022-06-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_em_3d_fitting.entry_id          7VZF 
_em_3d_fitting.id                1 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_protocol      ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.method            ? 
# 
_em_3d_reconstruction.entry_id                    7VZF 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.num_particles               70067 
_em_3d_reconstruction.resolution                  2.95 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.symmetry_type               HELICAL 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.magnification_calibration   ? 
# 
_em_buffer.id            1 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.details              ? 
_em_entity_assembly.name                 'Human SOD1 amyloid fibril' 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.entity_id_list       1 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
# 
_em_imaging.id                              1 
_em_imaging.entry_id                        7VZF 
_em_imaging.accelerating_voltage            300 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.cryogen                         ? 
_em_imaging.details                         ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.nominal_defocus_min             1200 
_em_imaging.nominal_magnification           ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.specimen_id                     1 
_em_imaging.citation_id                     ? 
_em_imaging.date                            ? 
_em_imaging.temperature                     ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.astigmatism                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.specimen_holder_type            ? 
# 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.details               ? 
_em_vitrification.humidity              ? 
_em_vitrification.instrument            ? 
_em_vitrification.entry_id              7VZF 
_em_vitrification.citation_id           ? 
_em_vitrification.method                ? 
_em_vitrification.temp                  ? 
_em_vitrification.time_resolved_state   ? 
# 
_em_experiment.entry_id                7VZF 
_em_experiment.id                      1 
_em_experiment.aggregation_state       'HELICAL ARRAY' 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 ND2 A ASN 53  ? ? O C VAL 14  ? ? 1.97 
2 1 OG1 A THR 137 ? ? O B THR 137 ? ? 2.13 
3 1 OG1 B THR 137 ? ? O C THR 137 ? ? 2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLN A 15  ? ? -145.97 -157.94 
2  1 GLU A 21  ? ? -108.89 -65.04  
3  1 ASN A 26  ? ? -78.42  -165.64 
4  1 LYS A 30  ? ? 59.74   70.68   
5  1 HIS A 43  ? ? -165.03 109.33  
6  1 PHE A 45  ? ? -162.34 100.21  
7  1 ASP A 90  ? ? -93.90  -63.13  
8  1 ASP A 92  ? ? 62.85   -2.22   
9  1 LEU A 106 ? ? -142.97 47.18   
10 1 ASP A 124 ? ? 34.55   59.32   
11 1 THR A 135 ? ? 35.32   58.11   
12 1 ILE A 149 ? ? -120.68 -60.90  
13 1 GLN B 15  ? ? -146.04 -157.99 
14 1 GLU B 21  ? ? -108.94 -65.01  
15 1 ASN B 26  ? ? -78.43  -165.69 
16 1 LYS B 30  ? ? 59.75   70.69   
17 1 HIS B 43  ? ? -165.00 109.37  
18 1 PHE B 45  ? ? -162.36 100.25  
19 1 ASP B 90  ? ? -93.88  -63.10  
20 1 ASP B 92  ? ? 62.80   -2.17   
21 1 LEU B 106 ? ? -143.00 47.20   
22 1 ASP B 124 ? ? 34.57   59.36   
23 1 THR B 135 ? ? 35.42   58.04   
24 1 ILE B 149 ? ? -120.66 -60.97  
25 1 GLN C 15  ? ? -146.05 -158.01 
26 1 GLU C 21  ? ? -108.94 -65.02  
27 1 ASN C 26  ? ? -78.46  -165.65 
28 1 LYS C 30  ? ? 59.75   70.69   
29 1 HIS C 43  ? ? -164.99 109.34  
30 1 PHE C 45  ? ? -162.39 100.16  
31 1 ASP C 90  ? ? -93.92  -63.19  
32 1 ASP C 92  ? ? 62.77   -2.18   
33 1 LEU C 106 ? ? -143.03 47.21   
34 1 ASP C 124 ? ? 34.58   59.32   
35 1 THR C 135 ? ? 35.43   58.04   
36 1 ILE C 149 ? ? -120.65 -61.02  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 0  ? A MET 1  
2  1 Y 1 A ALA 1  ? A ALA 2  
3  1 Y 1 A THR 2  ? A THR 3  
4  1 Y 1 A GLY 56 ? A GLY 57 
5  1 Y 1 A CYS 57 ? A CYS 58 
6  1 Y 1 A THR 58 ? A THR 59 
7  1 Y 1 A SER 59 ? A SER 60 
8  1 Y 1 A ALA 60 ? A ALA 61 
9  1 Y 1 A GLY 61 ? A GLY 62 
10 1 Y 1 A PRO 62 ? A PRO 63 
11 1 Y 1 A HIS 63 ? A HIS 64 
12 1 Y 1 A PHE 64 ? A PHE 65 
13 1 Y 1 A ASN 65 ? A ASN 66 
14 1 Y 1 A PRO 66 ? A PRO 67 
15 1 Y 1 A LEU 67 ? A LEU 68 
16 1 Y 1 A SER 68 ? A SER 69 
17 1 Y 1 A ARG 69 ? A ARG 70 
18 1 Y 1 A LYS 70 ? A LYS 71 
19 1 Y 1 A HIS 71 ? A HIS 72 
20 1 Y 1 A GLY 72 ? A GLY 73 
21 1 Y 1 A GLY 73 ? A GLY 74 
22 1 Y 1 A PRO 74 ? A PRO 75 
23 1 Y 1 A LYS 75 ? A LYS 76 
24 1 Y 1 A ASP 76 ? A ASP 77 
25 1 Y 1 A GLU 77 ? A GLU 78 
26 1 Y 1 A GLU 78 ? A GLU 79 
27 1 Y 1 A ARG 79 ? A ARG 80 
28 1 Y 1 A HIS 80 ? A HIS 81 
29 1 Y 1 A VAL 81 ? A VAL 82 
30 1 Y 1 A GLY 82 ? A GLY 83 
31 1 Y 1 A ASP 83 ? A ASP 84 
32 1 Y 1 A LEU 84 ? A LEU 85 
33 1 Y 1 A GLY 85 ? A GLY 86 
34 1 Y 1 B MET 0  ? B MET 1  
35 1 Y 1 B ALA 1  ? B ALA 2  
36 1 Y 1 B THR 2  ? B THR 3  
37 1 Y 1 B GLY 56 ? B GLY 57 
38 1 Y 1 B CYS 57 ? B CYS 58 
39 1 Y 1 B THR 58 ? B THR 59 
40 1 Y 1 B SER 59 ? B SER 60 
41 1 Y 1 B ALA 60 ? B ALA 61 
42 1 Y 1 B GLY 61 ? B GLY 62 
43 1 Y 1 B PRO 62 ? B PRO 63 
44 1 Y 1 B HIS 63 ? B HIS 64 
45 1 Y 1 B PHE 64 ? B PHE 65 
46 1 Y 1 B ASN 65 ? B ASN 66 
47 1 Y 1 B PRO 66 ? B PRO 67 
48 1 Y 1 B LEU 67 ? B LEU 68 
49 1 Y 1 B SER 68 ? B SER 69 
50 1 Y 1 B ARG 69 ? B ARG 70 
51 1 Y 1 B LYS 70 ? B LYS 71 
52 1 Y 1 B HIS 71 ? B HIS 72 
53 1 Y 1 B GLY 72 ? B GLY 73 
54 1 Y 1 B GLY 73 ? B GLY 74 
55 1 Y 1 B PRO 74 ? B PRO 75 
56 1 Y 1 B LYS 75 ? B LYS 76 
57 1 Y 1 B ASP 76 ? B ASP 77 
58 1 Y 1 B GLU 77 ? B GLU 78 
59 1 Y 1 B GLU 78 ? B GLU 79 
60 1 Y 1 B ARG 79 ? B ARG 80 
61 1 Y 1 B HIS 80 ? B HIS 81 
62 1 Y 1 B VAL 81 ? B VAL 82 
63 1 Y 1 B GLY 82 ? B GLY 83 
64 1 Y 1 B ASP 83 ? B ASP 84 
65 1 Y 1 B LEU 84 ? B LEU 85 
66 1 Y 1 B GLY 85 ? B GLY 86 
67 1 Y 1 C MET 0  ? C MET 1  
68 1 Y 1 C ALA 1  ? C ALA 2  
69 1 Y 1 C THR 2  ? C THR 3  
70 1 Y 1 C GLY 56 ? C GLY 57 
71 1 Y 1 C CYS 57 ? C CYS 58 
72 1 Y 1 C THR 58 ? C THR 59 
73 1 Y 1 C SER 59 ? C SER 60 
74 1 Y 1 C ALA 60 ? C ALA 61 
75 1 Y 1 C GLY 61 ? C GLY 62 
76 1 Y 1 C PRO 62 ? C PRO 63 
77 1 Y 1 C HIS 63 ? C HIS 64 
78 1 Y 1 C PHE 64 ? C PHE 65 
79 1 Y 1 C ASN 65 ? C ASN 66 
80 1 Y 1 C PRO 66 ? C PRO 67 
81 1 Y 1 C LEU 67 ? C LEU 68 
82 1 Y 1 C SER 68 ? C SER 69 
83 1 Y 1 C ARG 69 ? C ARG 70 
84 1 Y 1 C LYS 70 ? C LYS 71 
85 1 Y 1 C HIS 71 ? C HIS 72 
86 1 Y 1 C GLY 72 ? C GLY 73 
87 1 Y 1 C GLY 73 ? C GLY 74 
88 1 Y 1 C PRO 74 ? C PRO 75 
89 1 Y 1 C LYS 75 ? C LYS 76 
90 1 Y 1 C ASP 76 ? C ASP 77 
91 1 Y 1 C GLU 77 ? C GLU 78 
92 1 Y 1 C GLU 78 ? C GLU 79 
93 1 Y 1 C ARG 79 ? C ARG 80 
94 1 Y 1 C HIS 80 ? C HIS 81 
95 1 Y 1 C VAL 81 ? C VAL 82 
96 1 Y 1 C GLY 82 ? C GLY 83 
97 1 Y 1 C ASP 83 ? C ASP 84 
98 1 Y 1 C LEU 84 ? C LEU 85 
99 1 Y 1 C GLY 85 ? C GLY 86 
# 
_em_ctf_correction.id                       1 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.type                     NONE 
_em_ctf_correction.details                  ? 
# 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
# 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.angular_rotation_per_subunit   -1.187 
_em_helical_entity.axial_rise_per_subunit         4.82 
_em_helical_entity.axial_symmetry                 C1 
_em_helical_entity.details                        ? 
# 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
_em_image_processing.details              ? 
# 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
# 
loop_
_em_software.id 
_em_software.category 
_em_software.details 
_em_software.name 
_em_software.version 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
1  'PARTICLE SELECTION'       ? ? ? 1 ? ? 
2  'IMAGE ACQUISITION'        ? ? ? ? ? 1 
3  MASKING                    ? ? ? ? ? ? 
4  'CTF CORRECTION'           ? ? ? 1 ? ? 
5  'LAYERLINE INDEXING'       ? ? ? ? ? ? 
6  'DIFFRACTION INDEXING'     ? ? ? ? ? ? 
7  'MODEL FITTING'            ? ? ? ? ? ? 
8  'MODEL REFINEMENT'         ? ? ? ? ? ? 
9  OTHER                      ? ? ? ? ? ? 
10 'INITIAL EULER ASSIGNMENT' ? ? ? 1 ? ? 
11 'FINAL EULER ASSIGNMENT'   ? ? ? 1 ? ? 
12 CLASSIFICATION             ? ? ? 1 ? ? 
13 RECONSTRUCTION             ? ? ? 1 ? ? 
# 
_em_specimen.id                      1 
_em_specimen.experiment_id           1 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Natural Science Foundation of China (NSFC)' China 31770833 1 
'National Natural Science Foundation of China (NSFC)' China 32071212 2 
'National Natural Science Foundation of China (NSFC)' China 31570779 3 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
