data_5J07
# 
_entry.id   5J07 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.287 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB   5J07         
WWPDB D_1000219742 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        5J07 
_pdbx_database_status.recvd_initial_deposition_date   2016-03-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
'Wang, H.'       1 
'Lang, L.'       2 
'Logan, D.'      3 
'Danielsson, J.' 4 
'Oliveberg, M.'  5 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'J. Am. Chem. Soc.' 
_citation.journal_id_ASTM           JACSAT 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1520-5126 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            138 
_citation.language                  ? 
_citation.page_first                15571 
_citation.page_last                 15579 
_citation.title                     'Tricking a Protein To Swap Strands.' 
_citation.year                      2016 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/jacs.6b05151 
_citation.pdbx_database_id_PubMed   27783493 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
primary 'Wang, H.'       1 
primary 'Lang, L.'       2 
primary 'Logan, D.T.'    3 
primary 'Danielsson, J.' 4 
primary 'Oliveberg, M.'  5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     5J07 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     75.040 
_cell.length_a_esd                 ? 
_cell.length_b                     75.040 
_cell.length_b_esd                 ? 
_cell.length_c                     59.010 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         5J07 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                170 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 65' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 
'Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn]' 11317.631 2  
1.15.1.1,1.15.1.1,1.15.1.1,1.15.1.1 ? ? ? 
2 water   nat water 18.015    85 ?                                   ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Superoxide dismutase 1,hSod1,Superoxide dismutase 1,hSod1,Superoxide dismutase 1,hSod1,Superoxide dismutase 1,hSod1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;APVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHGAGGDLGNVTADKDGVADVSIEDSVISLSGDHSIIGRTLVVHE
KAGAGAGSRLASGVIGIAQAGAGATKAVAVLKGDG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;APVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHGAGGDLGNVTADKDGVADVSIEDSVISLSGDHSIIGRTLVVHE
KAGAGAGSRLASGVIGIAQAGAGATKAVAVLKGDG
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   PRO n 
1 3   VAL n 
1 4   GLN n 
1 5   GLY n 
1 6   ILE n 
1 7   ILE n 
1 8   ASN n 
1 9   PHE n 
1 10  GLU n 
1 11  GLN n 
1 12  LYS n 
1 13  GLU n 
1 14  SER n 
1 15  ASN n 
1 16  GLY n 
1 17  PRO n 
1 18  VAL n 
1 19  LYS n 
1 20  VAL n 
1 21  TRP n 
1 22  GLY n 
1 23  SER n 
1 24  ILE n 
1 25  LYS n 
1 26  GLY n 
1 27  LEU n 
1 28  THR n 
1 29  GLU n 
1 30  GLY n 
1 31  LEU n 
1 32  HIS n 
1 33  GLY n 
1 34  PHE n 
1 35  HIS n 
1 36  VAL n 
1 37  HIS n 
1 38  GLY n 
1 39  ALA n 
1 40  GLY n 
1 41  GLY n 
1 42  ASP n 
1 43  LEU n 
1 44  GLY n 
1 45  ASN n 
1 46  VAL n 
1 47  THR n 
1 48  ALA n 
1 49  ASP n 
1 50  LYS n 
1 51  ASP n 
1 52  GLY n 
1 53  VAL n 
1 54  ALA n 
1 55  ASP n 
1 56  VAL n 
1 57  SER n 
1 58  ILE n 
1 59  GLU n 
1 60  ASP n 
1 61  SER n 
1 62  VAL n 
1 63  ILE n 
1 64  SER n 
1 65  LEU n 
1 66  SER n 
1 67  GLY n 
1 68  ASP n 
1 69  HIS n 
1 70  SER n 
1 71  ILE n 
1 72  ILE n 
1 73  GLY n 
1 74  ARG n 
1 75  THR n 
1 76  LEU n 
1 77  VAL n 
1 78  VAL n 
1 79  HIS n 
1 80  GLU n 
1 81  LYS n 
1 82  ALA n 
1 83  GLY n 
1 84  ALA n 
1 85  GLY n 
1 86  ALA n 
1 87  GLY n 
1 88  SER n 
1 89  ARG n 
1 90  LEU n 
1 91  ALA n 
1 92  SER n 
1 93  GLY n 
1 94  VAL n 
1 95  ILE n 
1 96  GLY n 
1 97  ILE n 
1 98  ALA n 
1 99  GLN n 
1 100 ALA n 
1 101 GLY n 
1 102 ALA n 
1 103 GLY n 
1 104 ALA n 
1 105 THR n 
1 106 LYS n 
1 107 ALA n 
1 108 VAL n 
1 109 ALA n 
1 110 VAL n 
1 111 LEU n 
1 112 LYS n 
1 113 GLY n 
1 114 ASP n 
1 115 GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   37  Human ? SOD1 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli K-12' 
83333 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 42  82  Human ? SOD1 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli K-12' 
83333 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 86  99  Human ? SOD1 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli K-12' 
83333 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 4 sample 'Biological sequence' 105 115 Human ? SOD1 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli K-12' 
83333 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP SODC_HUMAN P00441 ? 1 PVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVH      14  
2 UNP SODC_HUMAN P00441 ? 1 DLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKA 84  
3 UNP SODC_HUMAN P00441 ? 1 AGSRLACGVIGIAQ                            141 
4 UNP SODC_HUMAN P00441 ? 1 ATKAVCVLKGDG                              2   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 5J07 A 2   ? 37  ? P00441 14  ? 49  ? 2   37  
2 2 5J07 A 42  ? 82  ? P00441 84  ? 124 ? 42  82  
3 3 5J07 A 86  ? 99  ? P00441 141 ? 154 ? 86  99  
4 4 5J07 A 104 ? 115 ? P00441 2   ? 13  ? 104 115 
5 1 5J07 B 2   ? 37  ? P00441 14  ? 49  ? 2   37  
6 2 5J07 B 42  ? 82  ? P00441 84  ? 124 ? 42  82  
7 3 5J07 B 86  ? 99  ? P00441 141 ? 154 ? 86  99  
8 4 5J07 B 104 ? 115 ? P00441 2   ? 13  ? 104 115 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 5J07 ALA A 1   ? UNP P00441 ?   ?   'expression tag' 1   1  
1 5J07 GLY A 38  ? UNP P00441 ?   ?   linker           38  2  
1 5J07 ALA A 39  ? UNP P00441 ?   ?   linker           39  3  
1 5J07 GLY A 40  ? UNP P00441 ?   ?   linker           40  4  
1 5J07 GLY A 41  ? UNP P00441 ?   ?   linker           41  5  
2 5J07 SER A 70  ? UNP P00441 CYS 112 conflict         70  6  
2 5J07 GLY A 83  ? UNP P00441 ?   ?   linker           83  7  
2 5J07 ALA A 84  ? UNP P00441 ?   ?   linker           84  8  
2 5J07 GLY A 85  ? UNP P00441 ?   ?   linker           85  9  
3 5J07 SER A 92  ? UNP P00441 CYS 147 conflict         92  10 
3 5J07 ALA A 100 ? UNP P00441 ?   ?   linker           100 11 
3 5J07 GLY A 101 ? UNP P00441 ?   ?   linker           101 12 
3 5J07 ALA A 102 ? UNP P00441 ?   ?   linker           102 13 
3 5J07 GLY A 103 ? UNP P00441 ?   ?   linker           103 14 
4 5J07 ALA A 104 ? UNP P00441 ALA 2   linker           104 15 
4 5J07 ALA A 109 ? UNP P00441 CYS 7   conflict         109 16 
5 5J07 ALA B 1   ? UNP P00441 ?   ?   'expression tag' 1   17 
5 5J07 GLY B 38  ? UNP P00441 ?   ?   linker           38  18 
5 5J07 ALA B 39  ? UNP P00441 ?   ?   linker           39  19 
5 5J07 GLY B 40  ? UNP P00441 ?   ?   linker           40  20 
5 5J07 GLY B 41  ? UNP P00441 ?   ?   linker           41  21 
6 5J07 SER B 70  ? UNP P00441 CYS 112 conflict         70  22 
6 5J07 GLY B 83  ? UNP P00441 ?   ?   linker           83  23 
6 5J07 ALA B 84  ? UNP P00441 ?   ?   linker           84  24 
6 5J07 GLY B 85  ? UNP P00441 ?   ?   linker           85  25 
7 5J07 SER B 92  ? UNP P00441 CYS 147 conflict         92  26 
7 5J07 ALA B 100 ? UNP P00441 ?   ?   linker           100 27 
7 5J07 GLY B 101 ? UNP P00441 ?   ?   linker           101 28 
7 5J07 ALA B 102 ? UNP P00441 ?   ?   linker           102 29 
7 5J07 GLY B 103 ? UNP P00441 ?   ?   linker           103 30 
8 5J07 ALA B 104 ? UNP P00441 ALA 2   linker           104 31 
8 5J07 ALA B 109 ? UNP P00441 CYS 7   conflict         109 32 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   5J07 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            2.12 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         41.95 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          EVAPORATION 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            293 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
;
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.ambient_environment    ? 
_diffrn.ambient_temp           100 
_diffrn.ambient_temp_details   ? 
_diffrn.ambient_temp_esd       ? 
_diffrn.crystal_id             1 
_diffrn.crystal_support        ? 
_diffrn.crystal_treatment      ? 
_diffrn.details                ? 
_diffrn.id                     1 
_diffrn.ambient_pressure       ? 
_diffrn.ambient_pressure_esd   ? 
_diffrn.ambient_pressure_gt    ? 
_diffrn.ambient_pressure_lt    ? 
_diffrn.ambient_temp_gt        ? 
_diffrn.ambient_temp_lt        ? 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         MARRESEARCH 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2014-09-11 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'MAX II BEAMLINE I911-3' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I911-3 
_diffrn_source.pdbx_synchrotron_site       'MAX II' 
# 
_reflns.B_iso_Wilson_estimate            ? 
_reflns.entry_id                         5J07 
_reflns.data_reduction_details           ? 
_reflns.data_reduction_method            ? 
_reflns.d_resolution_high                2 
_reflns.d_resolution_low                 40 
_reflns.details                          ? 
_reflns.limit_h_max                      ? 
_reflns.limit_h_min                      ? 
_reflns.limit_k_max                      ? 
_reflns.limit_k_min                      ? 
_reflns.limit_l_max                      ? 
_reflns.limit_l_min                      ? 
_reflns.number_all                       ? 
_reflns.number_obs                       12893 
_reflns.observed_criterion               ? 
_reflns.observed_criterion_F_max         ? 
_reflns.observed_criterion_F_min         ? 
_reflns.observed_criterion_I_max         ? 
_reflns.observed_criterion_I_min         ? 
_reflns.observed_criterion_sigma_F       ? 
_reflns.observed_criterion_sigma_I       ? 
_reflns.percent_possible_obs             100 
_reflns.R_free_details                   ? 
_reflns.Rmerge_F_all                     ? 
_reflns.Rmerge_F_obs                     ? 
_reflns.Friedel_coverage                 ? 
_reflns.number_gt                        ? 
_reflns.threshold_expression             ? 
_reflns.pdbx_redundancy                  12.2 
_reflns.pdbx_Rmerge_I_obs                0.095 
_reflns.pdbx_Rmerge_I_all                ? 
_reflns.pdbx_Rsym_value                  ? 
_reflns.pdbx_netI_over_av_sigmaI         ? 
_reflns.pdbx_netI_over_sigmaI            15.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2   ? 
_reflns.pdbx_res_netI_over_sigmaI_2      ? 
_reflns.pdbx_chi_squared                 ? 
_reflns.pdbx_scaling_rejects             ? 
_reflns.pdbx_d_res_high_opt              ? 
_reflns.pdbx_d_res_low_opt               ? 
_reflns.pdbx_d_res_opt_method            ? 
_reflns.phase_calculation_details        ? 
_reflns.pdbx_Rrim_I_all                  ? 
_reflns.pdbx_Rpim_I_all                  ? 
_reflns.pdbx_d_opt                       ? 
_reflns.pdbx_number_measured_all         ? 
_reflns.pdbx_diffrn_id                   1 
_reflns.pdbx_ordinal                     1 
_reflns.pdbx_CC_half                     ? 
_reflns.pdbx_R_split                     ? 
# 
_reflns_shell.d_res_high                  2.00 
_reflns_shell.d_res_low                   2.05 
_reflns_shell.meanI_over_sigI_all         ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_all         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_possible             ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.number_unique_obs           ? 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.percent_possible_obs        ? 
_reflns_shell.Rmerge_F_all                ? 
_reflns_shell.Rmerge_F_obs                ? 
_reflns_shell.Rmerge_I_all                ? 
_reflns_shell.Rmerge_I_obs                0.618 
_reflns_shell.meanI_over_sigI_gt          ? 
_reflns_shell.meanI_over_uI_all           ? 
_reflns_shell.meanI_over_uI_gt            ? 
_reflns_shell.number_measured_gt          ? 
_reflns_shell.number_unique_gt            ? 
_reflns_shell.percent_possible_gt         ? 
_reflns_shell.Rmerge_F_gt                 ? 
_reflns_shell.Rmerge_I_gt                 ? 
_reflns_shell.pdbx_redundancy             ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.pdbx_chi_squared            ? 
_reflns_shell.pdbx_netI_over_sigmaI_all   ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs   ? 
_reflns_shell.pdbx_Rrim_I_all             ? 
_reflns_shell.pdbx_Rpim_I_all             ? 
_reflns_shell.pdbx_rejects                ? 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_CC_half                ? 
_reflns_shell.pdbx_R_split                ? 
# 
_refine.aniso_B[1][1]                            0.9600 
_refine.aniso_B[1][2]                            0.9600 
_refine.aniso_B[1][3]                            0.0000 
_refine.aniso_B[2][2]                            0.9600 
_refine.aniso_B[2][3]                            0.0000 
_refine.aniso_B[3][3]                            -3.1100 
_refine.B_iso_max                                130.040 
_refine.B_iso_mean                               49.8060 
_refine.B_iso_min                                20.140 
_refine.correlation_coeff_Fo_to_Fc               0.9560 
_refine.correlation_coeff_Fo_to_Fc_free          0.9350 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : WITH TLS ADDED' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 5J07 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.0000 
_refine.ls_d_res_low                             32.5100 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     12221 
_refine.ls_number_reflns_R_free                  644 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.9500 
_refine.ls_percent_reflns_R_free                 5.0000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1946 
_refine.ls_R_factor_R_free                       0.2306 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1927 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      4bcz 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.1740 
_refine.pdbx_solvent_vdw_probe_radii             1.2000 
_refine.pdbx_solvent_ion_probe_radii             0.8000 
_refine.pdbx_solvent_shrinkage_radii             0.8000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             15.0470 
_refine.overall_SU_ML                            0.1830 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.cycle_id                         final 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.d_res_high                       2.0000 
_refine_hist.d_res_low                        32.5100 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.number_atoms_solvent             85 
_refine_hist.number_atoms_total               1680 
_refine_hist.pdbx_number_residues_total       230 
_refine_hist.pdbx_B_iso_mean_solvent          52.33 
_refine_hist.pdbx_number_atoms_protein        1595 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.004  0.019  1615 ? r_bond_refined_d       ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1582 ? r_bond_other_d         ? ? 
'X-RAY DIFFRACTION' ? 0.880  1.944  2182 ? r_angle_refined_deg    ? ? 
'X-RAY DIFFRACTION' ? 0.801  3.000  3638 ? r_angle_other_deg      ? ? 
'X-RAY DIFFRACTION' ? 4.755  5.000  228  ? r_dihedral_angle_1_deg ? ? 
'X-RAY DIFFRACTION' ? 36.771 25.714 56   ? r_dihedral_angle_2_deg ? ? 
'X-RAY DIFFRACTION' ? 11.253 15.000 252  ? r_dihedral_angle_3_deg ? ? 
'X-RAY DIFFRACTION' ? 9.748  15.000 4    ? r_dihedral_angle_4_deg ? ? 
'X-RAY DIFFRACTION' ? 0.056  0.200  253  ? r_chiral_restr         ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.020  1904 ? r_gen_planes_refined   ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  336  ? r_gen_planes_other     ? ? 
'X-RAY DIFFRACTION' ? 3.174  4.119  918  ? r_mcbond_it            ? ? 
'X-RAY DIFFRACTION' ? 3.169  4.111  917  ? r_mcbond_other         ? ? 
'X-RAY DIFFRACTION' ? 4.112  6.155  1144 ? r_mcangle_it           ? ? 
'X-RAY DIFFRACTION' ? 7.113  3.000  3197 ? r_rigid_bond_restr     ? ? 
'X-RAY DIFFRACTION' ? 49.725 5.000  36   ? r_sphericity_free      ? ? 
'X-RAY DIFFRACTION' ? 32.341 5.000  3226 ? r_sphericity_bonded    ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.0010 
_refine_ls_shell.d_res_low                        2.0520 
_refine_ls_shell.number_reflns_all                941 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             45 
_refine_ls_shell.number_reflns_R_work             896 
_refine_ls_shell.percent_reflns_obs               100.0000 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free                  0.2720 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.2060 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
# 
_struct.entry_id                     5J07 
_struct.title                        
'Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2' 
_struct.pdbx_descriptor              
;Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn],Superoxide dismutase [Cu-Zn] (E.C.1.15.1.1,1.15.1.1,1.15.1.1,1.15.1.1)
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               ? 
# 
_struct_keywords.entry_id        5J07 
_struct_keywords.text            'SOD1, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 101 A . ? GLY 101 A ALA 102 A ? ALA 102 A 1 -2.94 
2 GLY 101 B . ? GLY 101 B ALA 102 B ? ALA 102 B 1 2.70  
3 ALA 102 B . ? ALA 102 B GLY 103 B ? GLY 103 B 1 -6.67 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? anti-parallel 
AA2 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASP A 42  ? ALA A 48  ? ASP A 42  ALA A 48  
AA1 2 GLY A 30  ? VAL A 36  ? GLY A 30  VAL A 36  
AA1 3 THR A 75  ? HIS A 79  ? THR A 75  HIS A 79  
AA1 4 LEU A 90  ? ALA A 100 ? LEU A 90  ALA A 100 
AA1 5 THR A 105 ? LYS A 112 ? THR A 105 LYS A 112 
AA1 6 GLN A 4   ? GLN A 11  ? GLN A 4   GLN A 11  
AA1 7 VAL A 18  ? LYS A 25  ? VAL A 18  LYS A 25  
AA1 8 ALA A 54  ? ASP A 60  ? ALA A 54  ASP A 60  
AA2 1 ASP B 42  ? ALA B 48  ? ASP B 42  ALA B 48  
AA2 2 GLY B 30  ? VAL B 36  ? GLY B 30  VAL B 36  
AA2 3 THR B 75  ? HIS B 79  ? THR B 75  HIS B 79  
AA2 4 LEU B 90  ? GLN B 99  ? LEU B 90  GLN B 99  
AA2 5 THR B 105 ? LYS B 112 ? THR B 105 LYS B 112 
AA2 6 GLN B 4   ? GLN B 11  ? GLN B 4   GLN B 11  
AA2 7 VAL B 18  ? LYS B 25  ? VAL B 18  LYS B 25  
AA2 8 ALA B 54  ? ASP B 60  ? ALA B 54  ASP B 60  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ALA A 48  ? O ALA A 48  N GLY A 30  ? N GLY A 30  
AA1 2 3 N HIS A 35  ? N HIS A 35  O VAL A 77  ? O VAL A 77  
AA1 3 4 N LEU A 76  ? N LEU A 76  O GLY A 93  ? O GLY A 93  
AA1 4 5 N ALA A 98  ? N ALA A 98  O LYS A 106 ? O LYS A 106 
AA1 5 6 O THR A 105 ? O THR A 105 N GLN A 11  ? N GLN A 11  
AA1 6 7 N GLN A 4   ? N GLN A 4   O LYS A 25  ? O LYS A 25  
AA1 7 8 N VAL A 20  ? N VAL A 20  O ILE A 58  ? O ILE A 58  
AA2 1 2 O ALA B 48  ? O ALA B 48  N GLY B 30  ? N GLY B 30  
AA2 2 3 N GLY B 33  ? N GLY B 33  O HIS B 79  ? O HIS B 79  
AA2 3 4 N LEU B 76  ? N LEU B 76  O GLY B 93  ? O GLY B 93  
AA2 4 5 N GLY B 96  ? N GLY B 96  O VAL B 108 ? O VAL B 108 
AA2 5 6 O ALA B 107 ? O ALA B 107 N PHE B 9   ? N PHE B 9   
AA2 6 7 N ASN B 8   ? N ASN B 8   O TRP B 21  ? O TRP B 21  
AA2 7 8 N VAL B 20  ? N VAL B 20  O ILE B 58  ? O ILE B 58  
# 
_atom_sites.entry_id                    5J07 
_atom_sites.fract_transf_matrix[1][1]   0.013326 
_atom_sites.fract_transf_matrix[1][2]   0.007694 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015388 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016946 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
# 
loop_
_atom_type.symbol 
C 
N 
O 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 1   ? 8.133  -6.965  -3.018  1.00 82.27  ? 1   ALA A N   1 
ATOM   2    C CA  . ALA A 1 1   ? 8.439  -6.331  -1.700  1.00 76.87  ? 1   ALA A CA  1 
ATOM   3    C C   . ALA A 1 1   ? 9.633  -5.387  -1.807  1.00 73.55  ? 1   ALA A C   1 
ATOM   4    O O   . ALA A 1 1   ? 10.274 -5.319  -2.859  1.00 80.07  ? 1   ALA A O   1 
ATOM   5    C CB  . ALA A 1 1   ? 8.716  -7.403  -0.660  1.00 76.06  ? 1   ALA A CB  1 
ATOM   6    N N   . PRO A 1 2   ? 9.925  -4.640  -0.727  1.00 66.91  ? 2   PRO A N   1 
ATOM   7    C CA  . PRO A 1 2   ? 11.204 -3.939  -0.669  1.00 57.98  ? 2   PRO A CA  1 
ATOM   8    C C   . PRO A 1 2   ? 12.389 -4.909  -0.707  1.00 50.54  ? 2   PRO A C   1 
ATOM   9    O O   . PRO A 1 2   ? 13.359 -4.650  -1.420  1.00 51.34  ? 2   PRO A O   1 
ATOM   10   C CB  . PRO A 1 2   ? 11.146 -3.202  0.673   1.00 60.87  ? 2   PRO A CB  1 
ATOM   11   C CG  . PRO A 1 2   ? 9.694  -3.003  0.926   1.00 63.42  ? 2   PRO A CG  1 
ATOM   12   C CD  . PRO A 1 2   ? 9.019  -4.219  0.358   1.00 67.74  ? 2   PRO A CD  1 
ATOM   13   N N   . VAL A 1 3   ? 12.298 -6.017  0.033   1.00 39.51  ? 3   VAL A N   1 
ATOM   14   C CA  . VAL A 1 3   ? 13.396 -6.994  0.085   1.00 34.42  ? 3   VAL A CA  1 
ATOM   15   C C   . VAL A 1 3   ? 13.353 -7.924  -1.124  1.00 32.72  ? 3   VAL A C   1 
ATOM   16   O O   . VAL A 1 3   ? 12.366 -8.634  -1.350  1.00 33.10  ? 3   VAL A O   1 
ATOM   17   C CB  . VAL A 1 3   ? 13.396 -7.830  1.381   1.00 35.13  ? 3   VAL A CB  1 
ATOM   18   C CG1 . VAL A 1 3   ? 14.573 -8.800  1.389   1.00 32.57  ? 3   VAL A CG1 1 
ATOM   19   C CG2 . VAL A 1 3   ? 13.464 -6.928  2.603   1.00 35.11  ? 3   VAL A CG2 1 
ATOM   20   N N   . GLN A 1 4   ? 14.431 -7.903  -1.900  1.00 31.60  ? 4   GLN A N   1 
ATOM   21   C CA  . GLN A 1 4   ? 14.571 -8.739  -3.084  1.00 31.06  ? 4   GLN A CA  1 
ATOM   22   C C   . GLN A 1 4   ? 16.020 -9.169  -3.230  1.00 26.46  ? 4   GLN A C   1 
ATOM   23   O O   . GLN A 1 4   ? 16.931 -8.461  -2.811  1.00 28.33  ? 4   GLN A O   1 
ATOM   24   C CB  . GLN A 1 4   ? 14.143 -7.981  -4.339  1.00 35.80  ? 4   GLN A CB  1 
ATOM   25   C CG  . GLN A 1 4   ? 12.682 -7.563  -4.351  1.00 38.90  ? 4   GLN A CG  1 
ATOM   26   C CD  . GLN A 1 4   ? 12.218 -7.074  -5.710  0.30 42.68  ? 4   GLN A CD  1 
ATOM   27   O OE1 . GLN A 1 4   ? 11.162 -7.481  -6.195  0.48 46.36  ? 4   GLN A OE1 1 
ATOM   28   N NE2 . GLN A 1 4   ? 13.005 -6.201  -6.335  0.77 44.01  ? 4   GLN A NE2 1 
ATOM   29   N N   . GLY A 1 5   ? 16.227 -10.330 -3.834  1.00 24.49  ? 5   GLY A N   1 
ATOM   30   C CA  . GLY A 1 5   ? 17.564 -10.841 -4.051  1.00 24.93  ? 5   GLY A CA  1 
ATOM   31   C C   . GLY A 1 5   ? 17.598 -12.021 -4.993  1.00 25.76  ? 5   GLY A C   1 
ATOM   32   O O   . GLY A 1 5   ? 16.571 -12.665 -5.257  1.00 26.99  ? 5   GLY A O   1 
ATOM   33   N N   . ILE A 1 6   ? 18.793 -12.289 -5.504  1.00 26.73  ? 6   ILE A N   1 
ATOM   34   C CA  . ILE A 1 6   ? 19.040 -13.449 -6.337  1.00 27.25  ? 6   ILE A CA  1 
ATOM   35   C C   . ILE A 1 6   ? 20.268 -14.151 -5.783  1.00 23.83  ? 6   ILE A C   1 
ATOM   36   O O   . ILE A 1 6   ? 21.326 -13.538 -5.660  1.00 25.71  ? 6   ILE A O   1 
ATOM   37   C CB  . ILE A 1 6   ? 19.297 -13.051 -7.797  1.00 30.83  ? 6   ILE A CB  1 
ATOM   38   C CG1 . ILE A 1 6   ? 18.104 -12.254 -8.362  1.00 30.99  ? 6   ILE A CG1 1 
ATOM   39   C CG2 . ILE A 1 6   ? 19.624 -14.288 -8.629  1.00 31.37  ? 6   ILE A CG2 1 
ATOM   40   C CD1 . ILE A 1 6   ? 17.112 -13.053 -9.175  1.00 32.91  ? 6   ILE A CD1 1 
ATOM   41   N N   . ILE A 1 7   ? 20.115 -15.424 -5.433  1.00 24.02  ? 7   ILE A N   1 
ATOM   42   C CA  . ILE A 1 7   ? 21.219 -16.223 -4.903  1.00 22.70  ? 7   ILE A CA  1 
ATOM   43   C C   . ILE A 1 7   ? 21.470 -17.422 -5.806  1.00 23.37  ? 7   ILE A C   1 
ATOM   44   O O   . ILE A 1 7   ? 20.550 -18.199 -6.102  1.00 25.72  ? 7   ILE A O   1 
ATOM   45   C CB  . ILE A 1 7   ? 20.943 -16.700 -3.462  1.00 23.17  ? 7   ILE A CB  1 
ATOM   46   C CG1 . ILE A 1 7   ? 20.727 -15.509 -2.517  1.00 22.13  ? 7   ILE A CG1 1 
ATOM   47   C CG2 . ILE A 1 7   ? 22.068 -17.600 -2.956  1.00 22.11  ? 7   ILE A CG2 1 
ATOM   48   C CD1 . ILE A 1 7   ? 21.923 -14.584 -2.367  1.00 22.91  ? 7   ILE A CD1 1 
ATOM   49   N N   . ASN A 1 8   ? 22.726 -17.572 -6.220  1.00 24.52  ? 8   ASN A N   1 
ATOM   50   C CA  . ASN A 1 8   ? 23.150 -18.660 -7.092  1.00 25.21  ? 8   ASN A CA  1 
ATOM   51   C C   . ASN A 1 8   ? 23.892 -19.729 -6.305  1.00 24.70  ? 8   ASN A C   1 
ATOM   52   O O   . ASN A 1 8   ? 24.599 -19.417 -5.348  1.00 27.09  ? 8   ASN A O   1 
ATOM   53   C CB  . ASN A 1 8   ? 24.055 -18.117 -8.198  1.00 26.06  ? 8   ASN A CB  1 
ATOM   54   C CG  . ASN A 1 8   ? 23.357 -17.084 -9.066  1.00 25.00  ? 8   ASN A CG  1 
ATOM   55   O OD1 . ASN A 1 8   ? 22.346 -17.380 -9.706  1.00 27.86  ? 8   ASN A OD1 1 
ATOM   56   N ND2 . ASN A 1 8   ? 23.890 -15.867 -9.096  1.00 25.32  ? 8   ASN A ND2 1 
ATOM   57   N N   . PHE A 1 9   ? 23.713 -20.983 -6.716  1.00 24.64  ? 9   PHE A N   1 
ATOM   58   C CA  . PHE A 1 9   ? 24.403 -22.132 -6.132  1.00 24.17  ? 9   PHE A CA  1 
ATOM   59   C C   . PHE A 1 9   ? 25.076 -22.905 -7.259  1.00 27.36  ? 9   PHE A C   1 
ATOM   60   O O   . PHE A 1 9   ? 24.458 -23.145 -8.297  1.00 30.52  ? 9   PHE A O   1 
ATOM   61   C CB  . PHE A 1 9   ? 23.410 -23.069 -5.431  1.00 23.50  ? 9   PHE A CB  1 
ATOM   62   C CG  . PHE A 1 9   ? 22.652 -22.429 -4.302  1.00 24.04  ? 9   PHE A CG  1 
ATOM   63   C CD1 . PHE A 1 9   ? 21.571 -21.590 -4.558  1.00 21.67  ? 9   PHE A CD1 1 
ATOM   64   C CD2 . PHE A 1 9   ? 23.016 -22.665 -2.980  1.00 25.32  ? 9   PHE A CD2 1 
ATOM   65   C CE1 . PHE A 1 9   ? 20.869 -21.004 -3.519  1.00 24.25  ? 9   PHE A CE1 1 
ATOM   66   C CE2 . PHE A 1 9   ? 22.319 -22.077 -1.936  1.00 23.40  ? 9   PHE A CE2 1 
ATOM   67   C CZ  . PHE A 1 9   ? 21.243 -21.244 -2.208  1.00 23.29  ? 9   PHE A CZ  1 
ATOM   68   N N   . GLU A 1 10  ? 26.331 -23.300 -7.060  1.00 26.94  ? 10  GLU A N   1 
ATOM   69   C CA  . GLU A 1 10  ? 27.062 -24.076 -8.064  1.00 30.20  ? 10  GLU A CA  1 
ATOM   70   C C   . GLU A 1 10  ? 27.871 -25.198 -7.439  1.00 32.78  ? 10  GLU A C   1 
ATOM   71   O O   . GLU A 1 10  ? 28.553 -24.997 -6.442  1.00 35.25  ? 10  GLU A O   1 
ATOM   72   C CB  . GLU A 1 10  ? 27.981 -23.179 -8.878  1.00 35.37  ? 10  GLU A CB  1 
ATOM   73   C CG  . GLU A 1 10  ? 27.222 -22.168 -9.707  1.00 37.64  ? 10  GLU A CG  1 
ATOM   74   C CD  . GLU A 1 10  ? 28.127 -21.247 -10.475 1.00 44.09  ? 10  GLU A CD  1 
ATOM   75   O OE1 . GLU A 1 10  ? 28.944 -21.740 -11.278 1.00 46.76  ? 10  GLU A OE1 1 
ATOM   76   O OE2 . GLU A 1 10  ? 28.000 -20.025 -10.271 1.00 46.60  ? 10  GLU A OE2 1 
ATOM   77   N N   . GLN A 1 11  ? 27.777 -26.377 -8.046  1.00 33.97  ? 11  GLN A N   1 
ATOM   78   C CA  . GLN A 1 11  ? 28.479 -27.560 -7.577  1.00 35.80  ? 11  GLN A CA  1 
ATOM   79   C C   . GLN A 1 11  ? 29.011 -28.325 -8.783  1.00 40.08  ? 11  GLN A C   1 
ATOM   80   O O   . GLN A 1 11  ? 28.254 -28.655 -9.700  1.00 43.31  ? 11  GLN A O   1 
ATOM   81   C CB  . GLN A 1 11  ? 27.526 -28.446 -6.772  1.00 37.57  ? 11  GLN A CB  1 
ATOM   82   C CG  . GLN A 1 11  ? 28.214 -29.512 -5.936  1.00 39.39  ? 11  GLN A CG  1 
ATOM   83   C CD  . GLN A 1 11  ? 27.231 -30.428 -5.223  1.00 39.62  ? 11  GLN A CD  1 
ATOM   84   O OE1 . GLN A 1 11  ? 26.152 -30.736 -5.743  1.00 43.01  ? 11  GLN A OE1 1 
ATOM   85   N NE2 . GLN A 1 11  ? 27.601 -30.876 -4.027  1.00 42.08  ? 11  GLN A NE2 1 
ATOM   86   N N   . LYS A 1 12  ? 30.311 -28.604 -8.778  1.00 41.95  ? 12  LYS A N   1 
ATOM   87   C CA  . LYS A 1 12  ? 30.949 -29.316 -9.881  1.00 46.86  ? 12  LYS A CA  1 
ATOM   88   C C   . LYS A 1 12  ? 30.709 -30.823 -9.780  1.00 48.68  ? 12  LYS A C   1 
ATOM   89   O O   . LYS A 1 12  ? 30.396 -31.471 -10.779 1.00 52.78  ? 12  LYS A O   1 
ATOM   90   C CB  . LYS A 1 12  ? 32.454 -29.034 -9.898  1.00 55.23  ? 12  LYS A CB  1 
ATOM   91   C CG  . LYS A 1 12  ? 33.126 -29.346 -11.228 1.00 63.23  ? 12  LYS A CG  1 
ATOM   92   C CD  . LYS A 1 12  ? 34.574 -29.782 -11.057 1.00 68.20  ? 12  LYS A CD  1 
ATOM   93   C CE  . LYS A 1 12  ? 35.434 -28.694 -10.434 1.00 75.49  ? 12  LYS A CE  1 
ATOM   94   N NZ  . LYS A 1 12  ? 36.861 -29.111 -10.339 1.00 80.56  ? 12  LYS A NZ  1 
ATOM   95   N N   . GLU A 1 13  ? 30.852 -31.366 -8.570  1.00 48.12  ? 13  GLU A N   1 
ATOM   96   C CA  . GLU A 1 13  ? 30.805 -32.815 -8.339  1.00 50.83  ? 13  GLU A CA  1 
ATOM   97   C C   . GLU A 1 13  ? 29.819 -33.205 -7.246  1.00 49.72  ? 13  GLU A C   1 
ATOM   98   O O   . GLU A 1 13  ? 29.538 -32.417 -6.351  1.00 55.86  ? 13  GLU A O   1 
ATOM   99   C CB  . GLU A 1 13  ? 32.195 -33.323 -7.949  1.00 57.00  ? 13  GLU A CB  1 
ATOM   100  C CG  . GLU A 1 13  ? 33.192 -33.331 -9.093  1.00 62.54  ? 13  GLU A CG  1 
ATOM   101  C CD  . GLU A 1 13  ? 34.622 -33.544 -8.633  1.00 66.46  ? 13  GLU A CD  1 
ATOM   102  O OE1 . GLU A 1 13  ? 34.827 -33.980 -7.479  1.00 67.28  ? 13  GLU A OE1 1 
ATOM   103  O OE2 . GLU A 1 13  ? 35.545 -33.275 -9.430  1.00 68.74  ? 13  GLU A OE2 1 
ATOM   104  N N   . SER A 1 14  ? 29.350 -34.452 -7.307  1.00 49.13  ? 14  SER A N   1 
ATOM   105  C CA  . SER A 1 14  ? 28.335 -34.984 -6.387  1.00 59.20  ? 14  SER A CA  1 
ATOM   106  C C   . SER A 1 14  ? 28.495 -34.521 -4.936  1.00 59.04  ? 14  SER A C   1 
ATOM   107  O O   . SER A 1 14  ? 27.603 -33.870 -4.389  1.00 75.64  ? 14  SER A O   1 
ATOM   108  C CB  . SER A 1 14  ? 28.333 -36.518 -6.442  1.00 59.17  ? 14  SER A CB  1 
ATOM   109  O OG  . SER A 1 14  ? 27.404 -37.067 -5.524  1.00 67.77  ? 14  SER A OG  1 
ATOM   110  N N   . ASN A 1 15  ? 29.624 -34.866 -4.320  1.00 63.32  ? 15  ASN A N   1 
ATOM   111  C CA  . ASN A 1 15  ? 29.901 -34.479 -2.931  1.00 66.53  ? 15  ASN A CA  1 
ATOM   112  C C   . ASN A 1 15  ? 30.722 -33.198 -2.802  1.00 62.53  ? 15  ASN A C   1 
ATOM   113  O O   . ASN A 1 15  ? 30.977 -32.733 -1.689  1.00 71.31  ? 15  ASN A O   1 
ATOM   114  C CB  . ASN A 1 15  ? 30.614 -35.620 -2.186  1.00 69.75  ? 15  ASN A CB  1 
ATOM   115  C CG  . ASN A 1 15  ? 29.665 -36.721 -1.743  1.00 73.32  ? 15  ASN A CG  1 
ATOM   116  O OD1 . ASN A 1 15  ? 29.959 -37.907 -1.911  1.00 75.94  ? 15  ASN A OD1 1 
ATOM   117  N ND2 . ASN A 1 15  ? 28.529 -36.339 -1.162  1.00 73.43  ? 15  ASN A ND2 1 
ATOM   118  N N   . GLY A 1 16  ? 31.122 -32.625 -3.935  1.00 56.06  ? 16  GLY A N   1 
ATOM   119  C CA  . GLY A 1 16  ? 31.977 -31.440 -3.949  1.00 50.27  ? 16  GLY A CA  1 
ATOM   120  C C   . GLY A 1 16  ? 31.334 -30.221 -3.309  1.00 46.07  ? 16  GLY A C   1 
ATOM   121  O O   . GLY A 1 16  ? 30.109 -30.155 -3.179  1.00 46.09  ? 16  GLY A O   1 
ATOM   122  N N   . PRO A 1 17  ? 32.159 -29.237 -2.910  1.00 44.75  ? 17  PRO A N   1 
ATOM   123  C CA  . PRO A 1 17  ? 31.624 -28.067 -2.217  1.00 41.61  ? 17  PRO A CA  1 
ATOM   124  C C   . PRO A 1 17  ? 30.677 -27.248 -3.097  1.00 39.56  ? 17  PRO A C   1 
ATOM   125  O O   . PRO A 1 17  ? 30.735 -27.333 -4.327  1.00 36.90  ? 17  PRO A O   1 
ATOM   126  C CB  . PRO A 1 17  ? 32.879 -27.259 -1.857  1.00 45.22  ? 17  PRO A CB  1 
ATOM   127  C CG  . PRO A 1 17  ? 33.921 -27.703 -2.824  1.00 46.06  ? 17  PRO A CG  1 
ATOM   128  C CD  . PRO A 1 17  ? 33.611 -29.133 -3.149  1.00 43.44  ? 17  PRO A CD  1 
ATOM   129  N N   . VAL A 1 18  ? 29.804 -26.476 -2.460  1.00 33.13  ? 18  VAL A N   1 
ATOM   130  C CA  . VAL A 1 18  ? 28.836 -25.655 -3.177  1.00 30.41  ? 18  VAL A CA  1 
ATOM   131  C C   . VAL A 1 18  ? 29.202 -24.180 -3.041  1.00 33.29  ? 18  VAL A C   1 
ATOM   132  O O   . VAL A 1 18  ? 29.307 -23.661 -1.930  1.00 36.23  ? 18  VAL A O   1 
ATOM   133  C CB  . VAL A 1 18  ? 27.401 -25.882 -2.656  1.00 29.67  ? 18  VAL A CB  1 
ATOM   134  C CG1 . VAL A 1 18  ? 26.402 -25.019 -3.424  1.00 30.46  ? 18  VAL A CG1 1 
ATOM   135  C CG2 . VAL A 1 18  ? 27.024 -27.355 -2.760  1.00 31.64  ? 18  VAL A CG2 1 
ATOM   136  N N   . LYS A 1 19  ? 29.404 -23.520 -4.178  1.00 32.10  ? 19  LYS A N   1 
ATOM   137  C CA  . LYS A 1 19  ? 29.622 -22.078 -4.216  1.00 32.02  ? 19  LYS A CA  1 
ATOM   138  C C   . LYS A 1 19  ? 28.263 -21.387 -4.147  1.00 30.89  ? 19  LYS A C   1 
ATOM   139  O O   . LYS A 1 19  ? 27.366 -21.718 -4.924  1.00 31.20  ? 19  LYS A O   1 
ATOM   140  C CB  . LYS A 1 19  ? 30.347 -21.676 -5.504  1.00 39.97  ? 19  LYS A CB  1 
ATOM   141  C CG  . LYS A 1 19  ? 31.749 -22.258 -5.640  1.00 45.94  ? 19  LYS A CG  1 
ATOM   142  C CD  . LYS A 1 19  ? 32.126 -22.510 -7.094  1.00 57.97  ? 19  LYS A CD  1 
ATOM   143  C CE  . LYS A 1 19  ? 31.520 -23.809 -7.610  1.00 63.91  ? 19  LYS A CE  1 
ATOM   144  N NZ  . LYS A 1 19  ? 31.853 -24.073 -9.037  1.00 69.90  ? 19  LYS A NZ  1 
ATOM   145  N N   . VAL A 1 20  ? 28.109 -20.457 -3.207  1.00 29.71  ? 20  VAL A N   1 
ATOM   146  C CA  . VAL A 1 20  ? 26.869 -19.687 -3.054  1.00 25.99  ? 20  VAL A CA  1 
ATOM   147  C C   . VAL A 1 20  ? 27.167 -18.200 -3.184  1.00 27.84  ? 20  VAL A C   1 
ATOM   148  O O   . VAL A 1 20  ? 27.956 -17.654 -2.414  1.00 31.37  ? 20  VAL A O   1 
ATOM   149  C CB  . VAL A 1 20  ? 26.221 -19.900 -1.674  1.00 27.15  ? 20  VAL A CB  1 
ATOM   150  C CG1 . VAL A 1 20  ? 24.872 -19.200 -1.603  1.00 28.05  ? 20  VAL A CG1 1 
ATOM   151  C CG2 . VAL A 1 20  ? 26.096 -21.384 -1.345  1.00 27.66  ? 20  VAL A CG2 1 
ATOM   152  N N   . TRP A 1 21  ? 26.525 -17.544 -4.143  1.00 24.99  ? 21  TRP A N   1 
ATOM   153  C CA  . TRP A 1 21  ? 26.797 -16.140 -4.392  1.00 24.92  ? 21  TRP A CA  1 
ATOM   154  C C   . TRP A 1 21  ? 25.612 -15.394 -4.989  1.00 24.62  ? 21  TRP A C   1 
ATOM   155  O O   . TRP A 1 21  ? 24.755 -15.976 -5.650  1.00 27.64  ? 21  TRP A O   1 
ATOM   156  C CB  . TRP A 1 21  ? 28.023 -15.991 -5.303  1.00 30.97  ? 21  TRP A CB  1 
ATOM   157  C CG  . TRP A 1 21  ? 27.810 -16.499 -6.698  1.00 29.67  ? 21  TRP A CG  1 
ATOM   158  C CD1 . TRP A 1 21  ? 27.873 -17.797 -7.120  1.00 30.09  ? 21  TRP A CD1 1 
ATOM   159  C CD2 . TRP A 1 21  ? 27.498 -15.716 -7.855  1.00 29.96  ? 21  TRP A CD2 1 
ATOM   160  N NE1 . TRP A 1 21  ? 27.619 -17.870 -8.468  1.00 30.28  ? 21  TRP A NE1 1 
ATOM   161  C CE2 . TRP A 1 21  ? 27.387 -16.605 -8.945  1.00 31.40  ? 21  TRP A CE2 1 
ATOM   162  C CE3 . TRP A 1 21  ? 27.298 -14.348 -8.075  1.00 29.27  ? 21  TRP A CE3 1 
ATOM   163  C CZ2 . TRP A 1 21  ? 27.092 -16.170 -10.240 1.00 31.33  ? 21  TRP A CZ2 1 
ATOM   164  C CZ3 . TRP A 1 21  ? 26.999 -13.914 -9.364  1.00 33.26  ? 21  TRP A CZ3 1 
ATOM   165  C CH2 . TRP A 1 21  ? 26.897 -14.822 -10.428 1.00 29.56  ? 21  TRP A CH2 1 
ATOM   166  N N   . GLY A 1 22  ? 25.591 -14.090 -4.750  1.00 24.55  ? 22  GLY A N   1 
ATOM   167  C CA  . GLY A 1 22  ? 24.549 -13.213 -5.264  1.00 24.91  ? 22  GLY A CA  1 
ATOM   168  C C   . GLY A 1 22  ? 24.466 -11.952 -4.430  1.00 25.56  ? 22  GLY A C   1 
ATOM   169  O O   . GLY A 1 22  ? 25.447 -11.550 -3.794  1.00 27.26  ? 22  GLY A O   1 
ATOM   170  N N   . SER A 1 23  ? 23.294 -11.326 -4.436  1.00 26.65  ? 23  SER A N   1 
ATOM   171  C CA  . SER A 1 23  ? 23.056 -10.129 -3.636  1.00 26.40  ? 23  SER A CA  1 
ATOM   172  C C   . SER A 1 23  ? 21.602 -10.049 -3.197  1.00 26.57  ? 23  SER A C   1 
ATOM   173  O O   . SER A 1 23  ? 20.703 -10.514 -3.900  1.00 27.47  ? 23  SER A O   1 
ATOM   174  C CB  . SER A 1 23  ? 23.439 -8.860  -4.411  1.00 30.99  ? 23  SER A CB  1 
ATOM   175  O OG  . SER A 1 23  ? 22.559 -8.630  -5.497  1.00 32.93  ? 23  SER A OG  1 
ATOM   176  N N   . ILE A 1 24  ? 21.393 -9.465  -2.022  1.00 26.54  ? 24  ILE A N   1 
ATOM   177  C CA  . ILE A 1 24  ? 20.059 -9.221  -1.485  1.00 22.38  ? 24  ILE A CA  1 
ATOM   178  C C   . ILE A 1 24  ? 19.955 -7.731  -1.214  1.00 24.56  ? 24  ILE A C   1 
ATOM   179  O O   . ILE A 1 24  ? 20.845 -7.156  -0.592  1.00 27.16  ? 24  ILE A O   1 
ATOM   180  C CB  . ILE A 1 24  ? 19.815 -9.982  -0.169  1.00 21.71  ? 24  ILE A CB  1 
ATOM   181  C CG1 . ILE A 1 24  ? 20.184 -11.462 -0.320  1.00 24.02  ? 24  ILE A CG1 1 
ATOM   182  C CG2 . ILE A 1 24  ? 18.356 -9.837  0.261   1.00 22.09  ? 24  ILE A CG2 1 
ATOM   183  C CD1 . ILE A 1 24  ? 20.235 -12.221 0.989   1.00 25.87  ? 24  ILE A CD1 1 
ATOM   184  N N   . LYS A 1 25  ? 18.863 -7.122  -1.675  1.00 26.48  ? 25  LYS A N   1 
ATOM   185  C CA  . LYS A 1 25  ? 18.655 -5.684  -1.570  1.00 30.60  ? 25  LYS A CA  1 
ATOM   186  C C   . LYS A 1 25  ? 17.384 -5.369  -0.790  1.00 31.11  ? 25  LYS A C   1 
ATOM   187  O O   . LYS A 1 25  ? 16.494 -6.218  -0.654  1.00 33.70  ? 25  LYS A O   1 
ATOM   188  C CB  . LYS A 1 25  ? 18.589 -5.070  -2.972  1.00 38.72  ? 25  LYS A CB  1 
ATOM   189  C CG  . LYS A 1 25  ? 19.712 -5.554  -3.884  1.00 43.65  ? 25  LYS A CG  1 
ATOM   190  C CD  . LYS A 1 25  ? 19.908 -4.667  -5.101  1.00 49.76  ? 25  LYS A CD  1 
ATOM   191  C CE  . LYS A 1 25  ? 21.066 -5.172  -5.950  1.00 54.83  ? 25  LYS A CE  1 
ATOM   192  N NZ  . LYS A 1 25  ? 21.489 -4.189  -6.986  1.00 59.25  ? 25  LYS A NZ  1 
ATOM   193  N N   . GLY A 1 26  ? 17.310 -4.146  -0.275  1.00 31.28  ? 26  GLY A N   1 
ATOM   194  C CA  . GLY A 1 26  ? 16.154 -3.696  0.496   1.00 35.51  ? 26  GLY A CA  1 
ATOM   195  C C   . GLY A 1 26  ? 16.182 -4.090  1.964   1.00 34.69  ? 26  GLY A C   1 
ATOM   196  O O   . GLY A 1 26  ? 15.167 -3.974  2.654   1.00 33.67  ? 26  GLY A O   1 
ATOM   197  N N   . LEU A 1 27  ? 17.342 -4.545  2.441   1.00 33.21  ? 27  LEU A N   1 
ATOM   198  C CA  . LEU A 1 27  ? 17.520 -4.953  3.836   1.00 32.77  ? 27  LEU A CA  1 
ATOM   199  C C   . LEU A 1 27  ? 17.876 -3.771  4.736   1.00 33.21  ? 27  LEU A C   1 
ATOM   200  O O   . LEU A 1 27  ? 18.415 -2.767  4.275   1.00 34.18  ? 27  LEU A O   1 
ATOM   201  C CB  . LEU A 1 27  ? 18.636 -6.002  3.953   1.00 29.25  ? 27  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 27  ? 18.399 -7.378  3.332   1.00 27.48  ? 27  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 27  ? 19.693 -8.179  3.292   1.00 28.53  ? 27  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 27  ? 17.331 -8.136  4.105   1.00 28.33  ? 27  LEU A CD2 1 
ATOM   205  N N   . THR A 1 28  ? 17.580 -3.903  6.026   1.00 28.71  ? 28  THR A N   1 
ATOM   206  C CA  . THR A 1 28  ? 18.062 -2.943  7.018   1.00 34.78  ? 28  THR A CA  1 
ATOM   207  C C   . THR A 1 28  ? 19.542 -3.212  7.260   1.00 33.79  ? 28  THR A C   1 
ATOM   208  O O   . THR A 1 28  ? 20.006 -4.341  7.095   1.00 34.10  ? 28  THR A O   1 
ATOM   209  C CB  . THR A 1 28  ? 17.308 -3.064  8.354   1.00 34.87  ? 28  THR A CB  1 
ATOM   210  O OG1 . THR A 1 28  ? 17.400 -4.411  8.839   1.00 37.31  ? 28  THR A OG1 1 
ATOM   211  C CG2 . THR A 1 28  ? 15.841 -2.680  8.181   1.00 34.33  ? 28  THR A CG2 1 
ATOM   212  N N   . GLU A 1 29  ? 20.272 -2.176  7.657   1.00 35.03  ? 29  GLU A N   1 
ATOM   213  C CA  . GLU A 1 29  ? 21.715 -2.280  7.873   1.00 35.83  ? 29  GLU A CA  1 
ATOM   214  C C   . GLU A 1 29  ? 22.041 -3.227  9.026   1.00 37.89  ? 29  GLU A C   1 
ATOM   215  O O   . GLU A 1 29  ? 21.462 -3.113  10.107  1.00 40.89  ? 29  GLU A O   1 
ATOM   216  C CB  . GLU A 1 29  ? 22.296 -0.899  8.175   1.00 36.66  ? 29  GLU A CB  1 
ATOM   217  C CG  . GLU A 1 29  ? 23.814 -0.863  8.302   1.00 39.36  ? 29  GLU A CG  1 
ATOM   218  C CD  . GLU A 1 29  ? 24.315 0.428   8.918   1.00 44.35  ? 29  GLU A CD  1 
ATOM   219  O OE1 . GLU A 1 29  ? 23.499 1.353   9.113   1.00 46.23  ? 29  GLU A OE1 1 
ATOM   220  O OE2 . GLU A 1 29  ? 25.526 0.518   9.211   1.00 47.18  ? 29  GLU A OE2 1 
ATOM   221  N N   . GLY A 1 30  ? 22.974 -4.148  8.790   1.00 35.54  ? 30  GLY A N   1 
ATOM   222  C CA  . GLY A 1 30  ? 23.431 -5.081  9.824   1.00 36.96  ? 30  GLY A CA  1 
ATOM   223  C C   . GLY A 1 30  ? 23.480 -6.531  9.375   1.00 35.91  ? 30  GLY A C   1 
ATOM   224  O O   . GLY A 1 30  ? 23.487 -6.823  8.178   1.00 34.48  ? 30  GLY A O   1 
ATOM   225  N N   . LEU A 1 31  ? 23.514 -7.434  10.354  1.00 34.26  ? 31  LEU A N   1 
ATOM   226  C CA  . LEU A 1 31  ? 23.576 -8.878  10.108  1.00 31.16  ? 31  LEU A CA  1 
ATOM   227  C C   . LEU A 1 31  ? 22.182 -9.476  9.946   1.00 30.87  ? 31  LEU A C   1 
ATOM   228  O O   . LEU A 1 31  ? 21.268 -9.143  10.695  1.00 32.05  ? 31  LEU A O   1 
ATOM   229  C CB  . LEU A 1 31  ? 24.282 -9.590  11.264  1.00 36.29  ? 31  LEU A CB  1 
ATOM   230  C CG  . LEU A 1 31  ? 25.778 -9.321  11.437  1.00 40.03  ? 31  LEU A CG  1 
ATOM   231  C CD1 . LEU A 1 31  ? 26.252 -9.818  12.794  1.00 45.15  ? 31  LEU A CD1 1 
ATOM   232  C CD2 . LEU A 1 31  ? 26.579 -9.972  10.320  1.00 43.29  ? 31  LEU A CD2 1 
ATOM   233  N N   . HIS A 1 32  ? 22.034 -10.374 8.978   1.00 29.10  ? 32  HIS A N   1 
ATOM   234  C CA  . HIS A 1 32  ? 20.754 -11.047 8.732   1.00 26.61  ? 32  HIS A CA  1 
ATOM   235  C C   . HIS A 1 32  ? 20.957 -12.546 8.597   1.00 28.40  ? 32  HIS A C   1 
ATOM   236  O O   . HIS A 1 32  ? 21.778 -12.990 7.791   1.00 30.08  ? 32  HIS A O   1 
ATOM   237  C CB  . HIS A 1 32  ? 20.101 -10.500 7.466   1.00 26.90  ? 32  HIS A CB  1 
ATOM   238  C CG  . HIS A 1 32  ? 19.715 -9.059  7.564   1.00 29.49  ? 32  HIS A CG  1 
ATOM   239  N ND1 . HIS A 1 32  ? 18.453 -8.649  7.941   1.00 36.19  ? 32  HIS A ND1 1 
ATOM   240  C CD2 . HIS A 1 32  ? 20.428 -7.930  7.343   1.00 30.95  ? 32  HIS A CD2 1 
ATOM   241  C CE1 . HIS A 1 32  ? 18.407 -7.328  7.941   1.00 31.70  ? 32  HIS A CE1 1 
ATOM   242  N NE2 . HIS A 1 32  ? 19.591 -6.868  7.583   1.00 32.02  ? 32  HIS A NE2 1 
ATOM   243  N N   . GLY A 1 33  ? 20.213 -13.315 9.391   1.00 28.04  ? 33  GLY A N   1 
ATOM   244  C CA  . GLY A 1 33  ? 20.248 -14.779 9.334   1.00 30.57  ? 33  GLY A CA  1 
ATOM   245  C C   . GLY A 1 33  ? 19.929 -15.280 7.939   1.00 28.42  ? 33  GLY A C   1 
ATOM   246  O O   . GLY A 1 33  ? 19.017 -14.773 7.284   1.00 29.70  ? 33  GLY A O   1 
ATOM   247  N N   . PHE A 1 34  ? 20.685 -16.279 7.496   1.00 29.89  ? 34  PHE A N   1 
ATOM   248  C CA  . PHE A 1 34  ? 20.678 -16.728 6.106   1.00 29.52  ? 34  PHE A CA  1 
ATOM   249  C C   . PHE A 1 34  ? 20.836 -18.245 6.093   1.00 29.47  ? 34  PHE A C   1 
ATOM   250  O O   . PHE A 1 34  ? 21.867 -18.769 6.510   1.00 32.42  ? 34  PHE A O   1 
ATOM   251  C CB  . PHE A 1 34  ? 21.838 -16.046 5.365   1.00 30.81  ? 34  PHE A CB  1 
ATOM   252  C CG  . PHE A 1 34  ? 21.881 -16.311 3.882   1.00 27.46  ? 34  PHE A CG  1 
ATOM   253  C CD1 . PHE A 1 34  ? 20.774 -16.064 3.076   1.00 27.84  ? 34  PHE A CD1 1 
ATOM   254  C CD2 . PHE A 1 34  ? 23.053 -16.764 3.281   1.00 27.98  ? 34  PHE A CD2 1 
ATOM   255  C CE1 . PHE A 1 34  ? 20.826 -16.289 1.709   1.00 26.67  ? 34  PHE A CE1 1 
ATOM   256  C CE2 . PHE A 1 34  ? 23.111 -16.989 1.915   1.00 27.08  ? 34  PHE A CE2 1 
ATOM   257  C CZ  . PHE A 1 34  ? 21.997 -16.750 1.127   1.00 25.30  ? 34  PHE A CZ  1 
ATOM   258  N N   . HIS A 1 35  ? 19.808 -18.954 5.639   1.00 29.46  ? 35  HIS A N   1 
ATOM   259  C CA  . HIS A 1 35  ? 19.832 -20.417 5.670   1.00 32.10  ? 35  HIS A CA  1 
ATOM   260  C C   . HIS A 1 35  ? 18.723 -21.060 4.854   1.00 31.55  ? 35  HIS A C   1 
ATOM   261  O O   . HIS A 1 35  ? 17.749 -20.411 4.470   1.00 29.86  ? 35  HIS A O   1 
ATOM   262  C CB  . HIS A 1 35  ? 19.757 -20.924 7.117   1.00 37.42  ? 35  HIS A CB  1 
ATOM   263  C CG  . HIS A 1 35  ? 18.804 -20.159 7.978   1.00 37.16  ? 35  HIS A CG  1 
ATOM   264  N ND1 . HIS A 1 35  ? 19.227 -19.293 8.964   1.00 41.49  ? 35  HIS A ND1 1 
ATOM   265  C CD2 . HIS A 1 35  ? 17.452 -20.119 7.996   1.00 38.66  ? 35  HIS A CD2 1 
ATOM   266  C CE1 . HIS A 1 35  ? 18.176 -18.757 9.556   1.00 41.31  ? 35  HIS A CE1 1 
ATOM   267  N NE2 . HIS A 1 35  ? 17.087 -19.240 8.987   1.00 41.96  ? 35  HIS A NE2 1 
ATOM   268  N N   . VAL A 1 36  ? 18.898 -22.352 4.596   1.00 31.44  ? 36  VAL A N   1 
ATOM   269  C CA  . VAL A 1 36  ? 17.881 -23.156 3.943   1.00 31.57  ? 36  VAL A CA  1 
ATOM   270  C C   . VAL A 1 36  ? 16.938 -23.644 5.037   1.00 32.65  ? 36  VAL A C   1 
ATOM   271  O O   . VAL A 1 36  ? 17.387 -24.100 6.094   1.00 33.33  ? 36  VAL A O   1 
ATOM   272  C CB  . VAL A 1 36  ? 18.495 -24.356 3.187   1.00 33.09  ? 36  VAL A CB  1 
ATOM   273  C CG1 . VAL A 1 36  ? 17.423 -25.124 2.425   1.00 32.90  ? 36  VAL A CG1 1 
ATOM   274  C CG2 . VAL A 1 36  ? 19.577 -23.881 2.224   1.00 34.56  ? 36  VAL A CG2 1 
ATOM   275  N N   . HIS A 1 37  ? 15.636 -23.523 4.796   1.00 32.83  ? 37  HIS A N   1 
ATOM   276  C CA  . HIS A 1 37  ? 14.637 -24.004 5.748   1.00 32.46  ? 37  HIS A CA  1 
ATOM   277  C C   . HIS A 1 37  ? 14.810 -25.505 5.976   1.00 36.26  ? 37  HIS A C   1 
ATOM   278  O O   . HIS A 1 37  ? 15.023 -26.257 5.027   1.00 38.50  ? 37  HIS A O   1 
ATOM   279  C CB  . HIS A 1 37  ? 13.225 -23.696 5.246   1.00 33.45  ? 37  HIS A CB  1 
ATOM   280  C CG  . HIS A 1 37  ? 12.144 -24.360 6.040   1.00 35.58  ? 37  HIS A CG  1 
ATOM   281  N ND1 . HIS A 1 37  ? 11.905 -24.067 7.365   1.00 36.63  ? 37  HIS A ND1 1 
ATOM   282  C CD2 . HIS A 1 37  ? 11.239 -25.305 5.694   1.00 38.41  ? 37  HIS A CD2 1 
ATOM   283  C CE1 . HIS A 1 37  ? 10.898 -24.803 7.801   1.00 37.52  ? 37  HIS A CE1 1 
ATOM   284  N NE2 . HIS A 1 37  ? 10.477 -25.563 6.807   1.00 38.97  ? 37  HIS A NE2 1 
ATOM   285  N N   . GLY A 1 38  ? 14.731 -25.927 7.235   1.00 36.87  ? 38  GLY A N   1 
ATOM   286  C CA  . GLY A 1 38  ? 14.928 -27.329 7.605   1.00 40.74  ? 38  GLY A CA  1 
ATOM   287  C C   . GLY A 1 38  ? 16.337 -27.594 8.108   1.00 46.48  ? 38  GLY A C   1 
ATOM   288  O O   . GLY A 1 38  ? 17.111 -26.661 8.348   1.00 47.82  ? 38  GLY A O   1 
ATOM   289  N N   . ALA A 1 39  ? 16.671 -28.872 8.257   1.00 51.16  ? 39  ALA A N   1 
ATOM   290  C CA  . ALA A 1 39  ? 17.959 -29.283 8.825   1.00 56.42  ? 39  ALA A CA  1 
ATOM   291  C C   . ALA A 1 39  ? 19.100 -29.217 7.806   1.00 59.25  ? 39  ALA A C   1 
ATOM   292  O O   . ALA A 1 39  ? 18.886 -29.396 6.606   1.00 55.56  ? 39  ALA A O   1 
ATOM   293  C CB  . ALA A 1 39  ? 17.852 -30.691 9.397   1.00 57.86  ? 39  ALA A CB  1 
ATOM   294  N N   . GLY A 1 40  ? 20.308 -28.954 8.303   1.00 59.34  ? 40  GLY A N   1 
ATOM   295  C CA  . GLY A 1 40  ? 21.531 -29.049 7.502   1.00 61.16  ? 40  GLY A CA  1 
ATOM   296  C C   . GLY A 1 40  ? 21.642 -28.046 6.370   1.00 58.34  ? 40  GLY A C   1 
ATOM   297  O O   . GLY A 1 40  ? 22.018 -28.404 5.252   1.00 64.02  ? 40  GLY A O   1 
ATOM   298  N N   . GLY A 1 41  ? 21.318 -26.789 6.659   1.00 52.21  ? 41  GLY A N   1 
ATOM   299  C CA  . GLY A 1 41  ? 21.405 -25.725 5.661   1.00 51.60  ? 41  GLY A CA  1 
ATOM   300  C C   . GLY A 1 41  ? 21.678 -24.349 6.239   1.00 49.01  ? 41  GLY A C   1 
ATOM   301  O O   . GLY A 1 41  ? 21.193 -23.347 5.710   1.00 32.62  ? 41  GLY A O   1 
ATOM   302  N N   . ASP A 1 42  ? 22.461 -24.298 7.315   1.00 58.20  ? 42  ASP A N   1 
ATOM   303  C CA  . ASP A 1 42  ? 22.864 -23.030 7.921   1.00 52.13  ? 42  ASP A CA  1 
ATOM   304  C C   . ASP A 1 42  ? 23.947 -22.375 7.067   1.00 45.98  ? 42  ASP A C   1 
ATOM   305  O O   . ASP A 1 42  ? 25.044 -22.918 6.925   1.00 49.70  ? 42  ASP A O   1 
ATOM   306  C CB  . ASP A 1 42  ? 23.383 -23.254 9.345   1.00 54.56  ? 42  ASP A CB  1 
ATOM   307  C CG  . ASP A 1 42  ? 23.947 -21.988 9.972   1.00 54.45  ? 42  ASP A CG  1 
ATOM   308  O OD1 . ASP A 1 42  ? 23.331 -20.911 9.826   1.00 56.85  ? 42  ASP A OD1 1 
ATOM   309  O OD2 . ASP A 1 42  ? 25.012 -22.072 10.619  1.00 59.46  ? 42  ASP A OD2 1 
ATOM   310  N N   . LEU A 1 43  ? 23.633 -21.213 6.499   1.00 40.48  ? 43  LEU A N   1 
ATOM   311  C CA  . LEU A 1 43  ? 24.598 -20.459 5.698   1.00 39.94  ? 43  LEU A CA  1 
ATOM   312  C C   . LEU A 1 43  ? 25.076 -19.201 6.424   1.00 36.86  ? 43  LEU A C   1 
ATOM   313  O O   . LEU A 1 43  ? 25.526 -18.246 5.795   1.00 40.34  ? 43  LEU A O   1 
ATOM   314  C CB  . LEU A 1 43  ? 23.999 -20.111 4.331   1.00 38.52  ? 43  LEU A CB  1 
ATOM   315  C CG  . LEU A 1 43  ? 23.503 -21.314 3.522   1.00 40.18  ? 43  LEU A CG  1 
ATOM   316  C CD1 . LEU A 1 43  ? 22.827 -20.860 2.239   1.00 41.16  ? 43  LEU A CD1 1 
ATOM   317  C CD2 . LEU A 1 43  ? 24.640 -22.281 3.212   1.00 40.55  ? 43  LEU A CD2 1 
ATOM   318  N N   . GLY A 1 44  ? 24.982 -19.216 7.751   1.00 30.19  ? 44  GLY A N   1 
ATOM   319  C CA  . GLY A 1 44  ? 25.501 -18.144 8.589   1.00 34.34  ? 44  GLY A CA  1 
ATOM   320  C C   . GLY A 1 44  ? 24.659 -16.885 8.515   1.00 33.56  ? 44  GLY A C   1 
ATOM   321  O O   . GLY A 1 44  ? 23.420 -16.949 8.469   1.00 35.96  ? 44  GLY A O   1 
ATOM   322  N N   . ASN A 1 45  ? 25.341 -15.745 8.516   1.00 36.65  ? 45  ASN A N   1 
ATOM   323  C CA  . ASN A 1 45  ? 24.712 -14.443 8.369   1.00 38.87  ? 45  ASN A CA  1 
ATOM   324  C C   . ASN A 1 45  ? 25.222 -13.737 7.127   1.00 35.18  ? 45  ASN A C   1 
ATOM   325  O O   . ASN A 1 45  ? 26.362 -13.958 6.704   1.00 35.78  ? 45  ASN A O   1 
ATOM   326  C CB  . ASN A 1 45  ? 25.019 -13.565 9.581   1.00 41.38  ? 45  ASN A CB  1 
ATOM   327  C CG  . ASN A 1 45  ? 24.380 -14.078 10.853  1.00 37.15  ? 45  ASN A CG  1 
ATOM   328  O OD1 . ASN A 1 45  ? 23.214 -14.475 10.859  1.00 37.99  ? 45  ASN A OD1 1 
ATOM   329  N ND2 . ASN A 1 45  ? 25.133 -14.053 11.946  1.00 41.70  ? 45  ASN A ND2 1 
ATOM   330  N N   . VAL A 1 46  ? 24.377 -12.884 6.555   1.00 34.48  ? 46  VAL A N   1 
ATOM   331  C CA  . VAL A 1 46  ? 24.804 -11.936 5.527   1.00 32.91  ? 46  VAL A CA  1 
ATOM   332  C C   . VAL A 1 46  ? 24.805 -10.537 6.130   1.00 30.89  ? 46  VAL A C   1 
ATOM   333  O O   . VAL A 1 46  ? 24.003 -10.234 7.017   1.00 31.64  ? 46  VAL A O   1 
ATOM   334  C CB  . VAL A 1 46  ? 23.917 -11.968 4.259   1.00 32.58  ? 46  VAL A CB  1 
ATOM   335  C CG1 . VAL A 1 46  ? 23.929 -13.357 3.637   1.00 34.35  ? 46  VAL A CG1 1 
ATOM   336  C CG2 . VAL A 1 46  ? 22.485 -11.509 4.548   1.00 32.31  ? 46  VAL A CG2 1 
ATOM   337  N N   . THR A 1 47  ? 25.714 -9.697  5.646   1.00 30.21  ? 47  THR A N   1 
ATOM   338  C CA  . THR A 1 47  ? 25.857 -8.325  6.130   1.00 29.01  ? 47  THR A CA  1 
ATOM   339  C C   . THR A 1 47  ? 25.314 -7.362  5.090   1.00 30.18  ? 47  THR A C   1 
ATOM   340  O O   . THR A 1 47  ? 25.789 -7.337  3.958   1.00 32.51  ? 47  THR A O   1 
ATOM   341  C CB  . THR A 1 47  ? 27.338 -7.994  6.416   1.00 30.33  ? 47  THR A CB  1 
ATOM   342  O OG1 . THR A 1 47  ? 27.804 -8.824  7.482   1.00 33.48  ? 47  THR A OG1 1 
ATOM   343  C CG2 . THR A 1 47  ? 27.523 -6.526  6.814   1.00 33.70  ? 47  THR A CG2 1 
ATOM   344  N N   . ALA A 1 48  ? 24.311 -6.577  5.475   1.00 28.98  ? 48  ALA A N   1 
ATOM   345  C CA  . ALA A 1 48  ? 23.765 -5.545  4.603   1.00 26.85  ? 48  ALA A CA  1 
ATOM   346  C C   . ALA A 1 48  ? 24.425 -4.215  4.949   1.00 31.75  ? 48  ALA A C   1 
ATOM   347  O O   . ALA A 1 48  ? 24.535 -3.865  6.125   1.00 32.68  ? 48  ALA A O   1 
ATOM   348  C CB  . ALA A 1 48  ? 22.257 -5.454  4.769   1.00 27.74  ? 48  ALA A CB  1 
ATOM   349  N N   . ASP A 1 49  ? 24.867 -3.486  3.926   1.00 32.04  ? 49  ASP A N   1 
ATOM   350  C CA  . ASP A 1 49  ? 25.528 -2.188  4.115   1.00 35.47  ? 49  ASP A CA  1 
ATOM   351  C C   . ASP A 1 49  ? 24.500 -1.076  4.370   1.00 37.52  ? 49  ASP A C   1 
ATOM   352  O O   . ASP A 1 49  ? 23.315 -1.360  4.559   1.00 38.37  ? 49  ASP A O   1 
ATOM   353  C CB  . ASP A 1 49  ? 26.429 -1.865  2.909   1.00 38.33  ? 49  ASP A CB  1 
ATOM   354  C CG  . ASP A 1 49  ? 25.648 -1.610  1.622   1.00 43.99  ? 49  ASP A CG  1 
ATOM   355  O OD1 . ASP A 1 49  ? 24.398 -1.579  1.644   1.00 47.47  ? 49  ASP A OD1 1 
ATOM   356  O OD2 . ASP A 1 49  ? 26.302 -1.439  0.574   1.00 52.45  ? 49  ASP A OD2 1 
ATOM   357  N N   . LYS A 1 50  ? 24.954 0.178   4.374   1.00 40.43  ? 50  LYS A N   1 
ATOM   358  C CA  . LYS A 1 50  ? 24.066 1.334   4.591   1.00 42.89  ? 50  LYS A CA  1 
ATOM   359  C C   . LYS A 1 50  ? 23.048 1.566   3.465   1.00 41.19  ? 50  LYS A C   1 
ATOM   360  O O   . LYS A 1 50  ? 22.015 2.197   3.686   1.00 45.18  ? 50  LYS A O   1 
ATOM   361  C CB  . LYS A 1 50  ? 24.881 2.614   4.822   1.00 46.72  ? 50  LYS A CB  1 
ATOM   362  C CG  . LYS A 1 50  ? 25.407 2.762   6.242   1.00 51.35  ? 50  LYS A CG  1 
ATOM   363  C CD  . LYS A 1 50  ? 25.904 4.176   6.510   1.00 56.65  ? 50  LYS A CD  1 
ATOM   364  C CE  . LYS A 1 50  ? 26.177 4.409   7.988   1.00 63.45  ? 50  LYS A CE  1 
ATOM   365  N NZ  . LYS A 1 50  ? 27.335 3.622   8.498   1.00 63.18  ? 50  LYS A NZ  1 
ATOM   366  N N   . ASP A 1 51  ? 23.346 1.069   2.267   1.00 40.30  ? 51  ASP A N   1 
ATOM   367  C CA  . ASP A 1 51  ? 22.382 1.077   1.161   1.00 40.74  ? 51  ASP A CA  1 
ATOM   368  C C   . ASP A 1 51  ? 21.338 -0.036  1.285   1.00 36.32  ? 51  ASP A C   1 
ATOM   369  O O   . ASP A 1 51  ? 20.382 -0.072  0.516   1.00 37.40  ? 51  ASP A O   1 
ATOM   370  C CB  . ASP A 1 51  ? 23.100 0.925   -0.184  1.00 43.82  ? 51  ASP A CB  1 
ATOM   371  C CG  . ASP A 1 51  ? 23.965 2.113   -0.525  1.00 45.34  ? 51  ASP A CG  1 
ATOM   372  O OD1 . ASP A 1 51  ? 23.740 3.202   0.044   1.00 46.92  ? 51  ASP A OD1 1 
ATOM   373  O OD2 . ASP A 1 51  ? 24.871 1.961   -1.372  1.00 52.02  ? 51  ASP A OD2 1 
ATOM   374  N N   . GLY A 1 52  ? 21.527 -0.943  2.240   1.00 33.75  ? 52  GLY A N   1 
ATOM   375  C CA  . GLY A 1 52  ? 20.627 -2.083  2.421   1.00 30.89  ? 52  GLY A CA  1 
ATOM   376  C C   . GLY A 1 52  ? 20.934 -3.245  1.492   1.00 30.02  ? 52  GLY A C   1 
ATOM   377  O O   . GLY A 1 52  ? 20.089 -4.113  1.276   1.00 28.82  ? 52  GLY A O   1 
ATOM   378  N N   . VAL A 1 53  ? 22.148 -3.259  0.947   1.00 30.46  ? 53  VAL A N   1 
ATOM   379  C CA  . VAL A 1 53  ? 22.581 -4.288  0.016   1.00 29.01  ? 53  VAL A CA  1 
ATOM   380  C C   . VAL A 1 53  ? 23.571 -5.217  0.701   1.00 28.98  ? 53  VAL A C   1 
ATOM   381  O O   . VAL A 1 53  ? 24.576 -4.771  1.268   1.00 29.72  ? 53  VAL A O   1 
ATOM   382  C CB  . VAL A 1 53  ? 23.247 -3.683  -1.237  1.00 34.03  ? 53  VAL A CB  1 
ATOM   383  C CG1 . VAL A 1 53  ? 23.745 -4.783  -2.170  1.00 34.90  ? 53  VAL A CG1 1 
ATOM   384  C CG2 . VAL A 1 53  ? 22.272 -2.771  -1.967  1.00 33.31  ? 53  VAL A CG2 1 
ATOM   385  N N   . ALA A 1 54  ? 23.279 -6.510  0.638   1.00 27.46  ? 54  ALA A N   1 
ATOM   386  C CA  . ALA A 1 54  ? 24.170 -7.538  1.146   1.00 24.95  ? 54  ALA A CA  1 
ATOM   387  C C   . ALA A 1 54  ? 24.705 -8.337  -0.029  1.00 26.78  ? 54  ALA A C   1 
ATOM   388  O O   . ALA A 1 54  ? 23.948 -9.038  -0.705  1.00 28.38  ? 54  ALA A O   1 
ATOM   389  C CB  . ALA A 1 54  ? 23.424 -8.449  2.108   1.00 20.52  ? 54  ALA A CB  1 
ATOM   390  N N   . ASP A 1 55  ? 26.004 -8.213  -0.286  1.00 28.03  ? 55  ASP A N   1 
ATOM   391  C CA  . ASP A 1 55  ? 26.671 -9.051  -1.275  1.00 28.81  ? 55  ASP A CA  1 
ATOM   392  C C   . ASP A 1 55  ? 27.018 -10.375 -0.619  1.00 32.20  ? 55  ASP A C   1 
ATOM   393  O O   . ASP A 1 55  ? 27.535 -10.399 0.499   1.00 37.25  ? 55  ASP A O   1 
ATOM   394  C CB  . ASP A 1 55  ? 27.933 -8.368  -1.809  1.00 30.45  ? 55  ASP A CB  1 
ATOM   395  C CG  . ASP A 1 55  ? 27.616 -7.155  -2.658  1.00 34.18  ? 55  ASP A CG  1 
ATOM   396  O OD1 . ASP A 1 55  ? 26.615 -7.189  -3.406  1.00 37.21  ? 55  ASP A OD1 1 
ATOM   397  O OD2 . ASP A 1 55  ? 28.360 -6.158  -2.577  1.00 38.00  ? 55  ASP A OD2 1 
ATOM   398  N N   . VAL A 1 56  ? 26.720 -11.471 -1.314  1.00 29.08  ? 56  VAL A N   1 
ATOM   399  C CA  . VAL A 1 56  ? 26.931 -12.817 -0.786  1.00 27.72  ? 56  VAL A CA  1 
ATOM   400  C C   . VAL A 1 56  ? 27.952 -13.569 -1.639  1.00 30.77  ? 56  VAL A C   1 
ATOM   401  O O   . VAL A 1 56  ? 27.850 -13.585 -2.865  1.00 31.27  ? 56  VAL A O   1 
ATOM   402  C CB  . VAL A 1 56  ? 25.602 -13.613 -0.759  1.00 25.56  ? 56  VAL A CB  1 
ATOM   403  C CG1 . VAL A 1 56  ? 25.799 -14.983 -0.127  1.00 27.60  ? 56  VAL A CG1 1 
ATOM   404  C CG2 . VAL A 1 56  ? 24.530 -12.838 -0.009  1.00 29.72  ? 56  VAL A CG2 1 
ATOM   405  N N   . SER A 1 57  ? 28.935 -14.182 -0.981  1.00 30.24  ? 57  SER A N   1 
ATOM   406  C CA  . SER A 1 57  ? 29.921 -15.040 -1.638  1.00 35.06  ? 57  SER A CA  1 
ATOM   407  C C   . SER A 1 57  ? 30.500 -16.016 -0.629  1.00 38.15  ? 57  SER A C   1 
ATOM   408  O O   . SER A 1 57  ? 31.374 -15.657 0.165   1.00 43.03  ? 57  SER A O   1 
ATOM   409  C CB  . SER A 1 57  ? 31.073 -14.229 -2.232  1.00 38.41  ? 57  SER A CB  1 
ATOM   410  O OG  . SER A 1 57  ? 31.818 -15.025 -3.141  1.00 43.00  ? 57  SER A OG  1 
ATOM   411  N N   . ILE A 1 58  ? 30.012 -17.246 -0.653  1.00 39.80  ? 58  ILE A N   1 
ATOM   412  C CA  . ILE A 1 58  ? 30.475 -18.245 0.293   1.00 44.27  ? 58  ILE A CA  1 
ATOM   413  C C   . ILE A 1 58  ? 30.673 -19.582 -0.396  1.00 41.41  ? 58  ILE A C   1 
ATOM   414  O O   . ILE A 1 58  ? 30.254 -19.784 -1.532  1.00 42.75  ? 58  ILE A O   1 
ATOM   415  C CB  . ILE A 1 58  ? 29.520 -18.361 1.497   1.00 50.62  ? 58  ILE A CB  1 
ATOM   416  C CG1 . ILE A 1 58  ? 28.121 -18.759 1.041   1.00 53.69  ? 58  ILE A CG1 1 
ATOM   417  C CG2 . ILE A 1 58  ? 29.453 -17.035 2.241   1.00 52.87  ? 58  ILE A CG2 1 
ATOM   418  C CD1 . ILE A 1 58  ? 27.155 -19.058 2.165   1.00 59.76  ? 58  ILE A CD1 1 
ATOM   419  N N   . GLU A 1 59  ? 31.365 -20.472 0.295   1.00 41.49  ? 59  GLU A N   1 
ATOM   420  C CA  . GLU A 1 59  ? 31.484 -21.852 -0.125  1.00 45.93  ? 59  GLU A CA  1 
ATOM   421  C C   . GLU A 1 59  ? 31.135 -22.701 1.075   1.00 46.82  ? 59  GLU A C   1 
ATOM   422  O O   . GLU A 1 59  ? 31.586 -22.426 2.183   1.00 47.22  ? 59  GLU A O   1 
ATOM   423  C CB  . GLU A 1 59  ? 32.889 -22.183 -0.628  1.00 51.03  ? 59  GLU A CB  1 
ATOM   424  C CG  . GLU A 1 59  ? 32.870 -23.345 -1.605  1.00 54.37  ? 59  GLU A CG  1 
ATOM   425  C CD  . GLU A 1 59  ? 34.225 -23.704 -2.174  1.00 59.34  ? 59  GLU A CD  1 
ATOM   426  O OE1 . GLU A 1 59  ? 34.660 -23.042 -3.140  1.00 64.54  ? 59  GLU A OE1 1 
ATOM   427  O OE2 . GLU A 1 59  ? 34.833 -24.674 -1.681  1.00 58.63  ? 59  GLU A OE2 1 
ATOM   428  N N   . ASP A 1 60  ? 30.303 -23.711 0.854   1.00 43.96  ? 60  ASP A N   1 
ATOM   429  C CA  . ASP A 1 60  ? 29.870 -24.588 1.927   1.00 44.47  ? 60  ASP A CA  1 
ATOM   430  C C   . ASP A 1 60  ? 29.918 -26.038 1.459   1.00 46.43  ? 60  ASP A C   1 
ATOM   431  O O   . ASP A 1 60  ? 29.533 -26.346 0.331   1.00 44.69  ? 60  ASP A O   1 
ATOM   432  C CB  . ASP A 1 60  ? 28.457 -24.214 2.375   1.00 49.39  ? 60  ASP A CB  1 
ATOM   433  C CG  . ASP A 1 60  ? 28.124 -24.751 3.751   1.00 52.89  ? 60  ASP A CG  1 
ATOM   434  O OD1 . ASP A 1 60  ? 28.668 -24.223 4.743   1.00 62.24  ? 60  ASP A OD1 1 
ATOM   435  O OD2 . ASP A 1 60  ? 27.318 -25.697 3.841   1.00 53.16  ? 60  ASP A OD2 1 
ATOM   436  N N   . SER A 1 61  ? 30.404 -26.917 2.332   1.00 48.02  ? 61  SER A N   1 
ATOM   437  C CA  . SER A 1 61  ? 30.549 -28.340 2.023   1.00 48.29  ? 61  SER A CA  1 
ATOM   438  C C   . SER A 1 61  ? 29.502 -29.210 2.723   1.00 53.14  ? 61  SER A C   1 
ATOM   439  O O   . SER A 1 61  ? 29.489 -30.430 2.542   1.00 56.88  ? 61  SER A O   1 
ATOM   440  C CB  . SER A 1 61  ? 31.950 -28.814 2.418   1.00 51.69  ? 61  SER A CB  1 
ATOM   441  O OG  . SER A 1 61  ? 32.946 -28.047 1.765   1.00 56.24  ? 61  SER A OG  1 
ATOM   442  N N   . VAL A 1 62  ? 28.637 -28.587 3.523   1.00 56.76  ? 62  VAL A N   1 
ATOM   443  C CA  . VAL A 1 62  ? 27.564 -29.303 4.215   1.00 61.03  ? 62  VAL A CA  1 
ATOM   444  C C   . VAL A 1 62  ? 26.380 -29.483 3.268   1.00 53.15  ? 62  VAL A C   1 
ATOM   445  O O   . VAL A 1 62  ? 25.871 -30.591 3.107   1.00 53.23  ? 62  VAL A O   1 
ATOM   446  C CB  . VAL A 1 62  ? 27.105 -28.557 5.489   1.00 67.54  ? 62  VAL A CB  1 
ATOM   447  C CG1 . VAL A 1 62  ? 25.995 -29.323 6.196   1.00 71.78  ? 62  VAL A CG1 1 
ATOM   448  C CG2 . VAL A 1 62  ? 28.279 -28.340 6.434   1.00 68.14  ? 62  VAL A CG2 1 
ATOM   449  N N   . ILE A 1 63  ? 25.945 -28.388 2.650   1.00 49.26  ? 63  ILE A N   1 
ATOM   450  C CA  . ILE A 1 63  ? 24.866 -28.439 1.659   1.00 41.50  ? 63  ILE A CA  1 
ATOM   451  C C   . ILE A 1 63  ? 25.341 -29.105 0.370   1.00 38.15  ? 63  ILE A C   1 
ATOM   452  O O   . ILE A 1 63  ? 26.541 -29.213 0.121   1.00 41.54  ? 63  ILE A O   1 
ATOM   453  C CB  . ILE A 1 63  ? 24.298 -27.037 1.326   1.00 37.22  ? 63  ILE A CB  1 
ATOM   454  C CG1 . ILE A 1 63  ? 25.390 -26.113 0.761   1.00 35.91  ? 63  ILE A CG1 1 
ATOM   455  C CG2 . ILE A 1 63  ? 23.650 -26.430 2.563   1.00 37.70  ? 63  ILE A CG2 1 
ATOM   456  C CD1 . ILE A 1 63  ? 24.861 -24.848 0.112   1.00 34.74  ? 63  ILE A CD1 1 
ATOM   457  N N   . SER A 1 64  ? 24.382 -29.530 -0.445  1.00 40.77  ? 64  SER A N   1 
ATOM   458  C CA  . SER A 1 64  ? 24.663 -30.185 -1.721  1.00 36.61  ? 64  SER A CA  1 
ATOM   459  C C   . SER A 1 64  ? 23.515 -29.911 -2.690  1.00 37.99  ? 64  SER A C   1 
ATOM   460  O O   . SER A 1 64  ? 22.411 -29.571 -2.267  1.00 38.79  ? 64  SER A O   1 
ATOM   461  C CB  . SER A 1 64  ? 24.842 -31.696 -1.513  1.00 37.22  ? 64  SER A CB  1 
ATOM   462  O OG  . SER A 1 64  ? 25.174 -32.356 -2.724  1.00 46.58  ? 64  SER A OG  1 
ATOM   463  N N   . LEU A 1 65  ? 23.786 -30.047 -3.985  1.00 39.26  ? 65  LEU A N   1 
ATOM   464  C CA  . LEU A 1 65  ? 22.762 -29.888 -5.021  1.00 36.65  ? 65  LEU A CA  1 
ATOM   465  C C   . LEU A 1 65  ? 22.335 -31.238 -5.611  1.00 40.51  ? 65  LEU A C   1 
ATOM   466  O O   . LEU A 1 65  ? 21.587 -31.288 -6.592  1.00 43.08  ? 65  LEU A O   1 
ATOM   467  C CB  . LEU A 1 65  ? 23.268 -28.955 -6.124  1.00 33.81  ? 65  LEU A CB  1 
ATOM   468  C CG  . LEU A 1 65  ? 23.645 -27.539 -5.676  1.00 33.05  ? 65  LEU A CG  1 
ATOM   469  C CD1 . LEU A 1 65  ? 24.107 -26.716 -6.867  1.00 33.41  ? 65  LEU A CD1 1 
ATOM   470  C CD2 . LEU A 1 65  ? 22.481 -26.848 -4.978  1.00 35.23  ? 65  LEU A CD2 1 
ATOM   471  N N   . SER A 1 66  ? 22.804 -32.322 -4.997  1.00 44.45  ? 66  SER A N   1 
ATOM   472  C CA  . SER A 1 66  ? 22.443 -33.683 -5.398  1.00 50.85  ? 66  SER A CA  1 
ATOM   473  C C   . SER A 1 66  ? 22.421 -34.595 -4.177  1.00 55.41  ? 66  SER A C   1 
ATOM   474  O O   . SER A 1 66  ? 22.949 -34.238 -3.122  1.00 55.13  ? 66  SER A O   1 
ATOM   475  C CB  . SER A 1 66  ? 23.434 -34.216 -6.436  1.00 56.79  ? 66  SER A CB  1 
ATOM   476  O OG  . SER A 1 66  ? 24.770 -34.127 -5.965  1.00 58.08  ? 66  SER A OG  1 
ATOM   477  N N   . GLY A 1 67  ? 21.798 -35.763 -4.323  1.00 58.84  ? 67  GLY A N   1 
ATOM   478  C CA  . GLY A 1 67  ? 21.705 -36.743 -3.237  1.00 67.26  ? 67  GLY A CA  1 
ATOM   479  C C   . GLY A 1 67  ? 20.533 -36.492 -2.304  1.00 70.25  ? 67  GLY A C   1 
ATOM   480  O O   . GLY A 1 67  ? 19.656 -35.674 -2.597  1.00 60.67  ? 67  GLY A O   1 
ATOM   481  N N   . ASP A 1 68  ? 20.522 -37.200 -1.176  1.00 73.24  ? 68  ASP A N   1 
ATOM   482  C CA  . ASP A 1 68  ? 19.436 -37.090 -0.193  1.00 80.70  ? 68  ASP A CA  1 
ATOM   483  C C   . ASP A 1 68  ? 19.495 -35.779 0.598   1.00 77.05  ? 68  ASP A C   1 
ATOM   484  O O   . ASP A 1 68  ? 18.475 -35.309 1.106   1.00 78.83  ? 68  ASP A O   1 
ATOM   485  C CB  . ASP A 1 68  ? 19.441 -38.291 0.767   1.00 87.38  ? 68  ASP A CB  1 
ATOM   486  C CG  . ASP A 1 68  ? 20.623 -38.280 1.726   1.00 92.87  ? 68  ASP A CG  1 
ATOM   487  O OD1 . ASP A 1 68  ? 21.749 -37.958 1.291   1.00 96.51  ? 68  ASP A OD1 1 
ATOM   488  O OD2 . ASP A 1 68  ? 20.423 -38.603 2.917   1.00 101.38 ? 68  ASP A OD2 1 
ATOM   489  N N   . HIS A 1 69  ? 20.689 -35.197 0.682   1.00 75.91  ? 69  HIS A N   1 
ATOM   490  C CA  . HIS A 1 69  ? 20.894 -33.909 1.343   1.00 76.21  ? 69  HIS A CA  1 
ATOM   491  C C   . HIS A 1 69  ? 20.732 -32.723 0.377   1.00 69.00  ? 69  HIS A C   1 
ATOM   492  O O   . HIS A 1 69  ? 21.105 -31.601 0.717   1.00 66.50  ? 69  HIS A O   1 
ATOM   493  C CB  . HIS A 1 69  ? 22.298 -33.834 1.966   1.00 85.40  ? 69  HIS A CB  1 
ATOM   494  C CG  . HIS A 1 69  ? 22.480 -34.670 3.196   1.00 95.60  ? 69  HIS A CG  1 
ATOM   495  N ND1 . HIS A 1 69  ? 23.727 -35.006 3.680   0.48 97.52  ? 69  HIS A ND1 1 
ATOM   496  C CD2 . HIS A 1 69  ? 21.585 -35.233 4.043   1.00 96.84  ? 69  HIS A CD2 1 
ATOM   497  C CE1 . HIS A 1 69  ? 23.592 -35.735 4.772   1.00 97.91  ? 69  HIS A CE1 1 
ATOM   498  N NE2 . HIS A 1 69  ? 22.303 -35.889 5.013   1.00 99.28  ? 69  HIS A NE2 1 
ATOM   499  N N   . SER A 1 70  ? 20.197 -32.974 -0.816  1.00 55.95  ? 70  SER A N   1 
ATOM   500  C CA  . SER A 1 70  ? 20.077 -31.940 -1.845  1.00 48.32  ? 70  SER A CA  1 
ATOM   501  C C   . SER A 1 70  ? 19.146 -30.824 -1.399  1.00 41.23  ? 70  SER A C   1 
ATOM   502  O O   . SER A 1 70  ? 18.043 -31.089 -0.904  1.00 47.25  ? 70  SER A O   1 
ATOM   503  C CB  . SER A 1 70  ? 19.555 -32.526 -3.159  1.00 50.05  ? 70  SER A CB  1 
ATOM   504  O OG  . SER A 1 70  ? 19.469 -31.521 -4.159  1.00 40.79  ? 70  SER A OG  1 
ATOM   505  N N   . ILE A 1 71  ? 19.586 -29.580 -1.595  1.00 33.78  ? 71  ILE A N   1 
ATOM   506  C CA  . ILE A 1 71  ? 18.776 -28.408 -1.246  1.00 33.09  ? 71  ILE A CA  1 
ATOM   507  C C   . ILE A 1 71  ? 17.886 -27.942 -2.402  1.00 30.38  ? 71  ILE A C   1 
ATOM   508  O O   . ILE A 1 71  ? 17.121 -26.994 -2.254  1.00 30.81  ? 71  ILE A O   1 
ATOM   509  C CB  . ILE A 1 71  ? 19.642 -27.238 -0.719  1.00 34.60  ? 71  ILE A CB  1 
ATOM   510  C CG1 . ILE A 1 71  ? 20.594 -26.704 -1.802  1.00 32.95  ? 71  ILE A CG1 1 
ATOM   511  C CG2 . ILE A 1 71  ? 20.411 -27.688 0.518   1.00 36.74  ? 71  ILE A CG2 1 
ATOM   512  C CD1 . ILE A 1 71  ? 21.363 -25.470 -1.384  1.00 31.98  ? 71  ILE A CD1 1 
ATOM   513  N N   . ILE A 1 72  ? 17.980 -28.622 -3.542  1.00 30.38  ? 72  ILE A N   1 
ATOM   514  C CA  . ILE A 1 72  ? 17.120 -28.340 -4.685  1.00 33.30  ? 72  ILE A CA  1 
ATOM   515  C C   . ILE A 1 72  ? 15.661 -28.535 -4.278  1.00 30.34  ? 72  ILE A C   1 
ATOM   516  O O   . ILE A 1 72  ? 15.286 -29.590 -3.758  1.00 30.58  ? 72  ILE A O   1 
ATOM   517  C CB  . ILE A 1 72  ? 17.439 -29.262 -5.880  1.00 35.61  ? 72  ILE A CB  1 
ATOM   518  C CG1 . ILE A 1 72  ? 18.880 -29.021 -6.379  1.00 33.84  ? 72  ILE A CG1 1 
ATOM   519  C CG2 . ILE A 1 72  ? 16.390 -29.101 -6.979  1.00 35.42  ? 72  ILE A CG2 1 
ATOM   520  C CD1 . ILE A 1 72  ? 19.162 -27.620 -6.888  1.00 33.19  ? 72  ILE A CD1 1 
ATOM   521  N N   . GLY A 1 73  ? 14.850 -27.508 -4.502  1.00 29.76  ? 73  GLY A N   1 
ATOM   522  C CA  . GLY A 1 73  ? 13.435 -27.551 -4.148  1.00 32.55  ? 73  GLY A CA  1 
ATOM   523  C C   . GLY A 1 73  ? 13.144 -27.126 -2.719  1.00 30.17  ? 73  GLY A C   1 
ATOM   524  O O   . GLY A 1 73  ? 11.983 -27.014 -2.337  1.00 32.07  ? 73  GLY A O   1 
ATOM   525  N N   . ARG A 1 74  ? 14.185 -26.901 -1.922  1.00 30.67  ? 74  ARG A N   1 
ATOM   526  C CA  . ARG A 1 74  ? 14.009 -26.377 -0.571  1.00 30.47  ? 74  ARG A CA  1 
ATOM   527  C C   . ARG A 1 74  ? 13.985 -24.852 -0.605  1.00 26.90  ? 74  ARG A C   1 
ATOM   528  O O   . ARG A 1 74  ? 14.373 -24.228 -1.599  1.00 28.89  ? 74  ARG A O   1 
ATOM   529  C CB  . ARG A 1 74  ? 15.092 -26.909 0.375   1.00 31.84  ? 74  ARG A CB  1 
ATOM   530  C CG  . ARG A 1 74  ? 14.907 -28.388 0.707   1.00 35.06  ? 74  ARG A CG  1 
ATOM   531  C CD  . ARG A 1 74  ? 16.058 -28.962 1.514   1.00 44.73  ? 74  ARG A CD  1 
ATOM   532  N NE  . ARG A 1 74  ? 16.156 -28.388 2.855   1.00 50.10  ? 74  ARG A NE  1 
ATOM   533  C CZ  . ARG A 1 74  ? 17.142 -28.642 3.716   1.00 53.96  ? 74  ARG A CZ  1 
ATOM   534  N NH1 . ARG A 1 74  ? 18.133 -29.466 3.389   1.00 52.19  ? 74  ARG A NH1 1 
ATOM   535  N NH2 . ARG A 1 74  ? 17.140 -28.066 4.912   1.00 57.85  ? 74  ARG A NH2 1 
ATOM   536  N N   . THR A 1 75  ? 13.512 -24.259 0.483   1.00 24.81  ? 75  THR A N   1 
ATOM   537  C CA  . THR A 1 75  ? 13.287 -22.825 0.537   1.00 23.24  ? 75  THR A CA  1 
ATOM   538  C C   . THR A 1 75  ? 14.474 -22.126 1.183   1.00 24.57  ? 75  THR A C   1 
ATOM   539  O O   . THR A 1 75  ? 14.885 -22.481 2.292   1.00 27.88  ? 75  THR A O   1 
ATOM   540  C CB  . THR A 1 75  ? 11.993 -22.504 1.305   1.00 23.66  ? 75  THR A CB  1 
ATOM   541  O OG1 . THR A 1 75  ? 10.882 -23.056 0.590   1.00 26.75  ? 75  THR A OG1 1 
ATOM   542  C CG2 . THR A 1 75  ? 11.795 -20.999 1.448   1.00 24.71  ? 75  THR A CG2 1 
ATOM   543  N N   . LEU A 1 76  ? 15.024 -21.147 0.467   1.00 21.42  ? 76  LEU A N   1 
ATOM   544  C CA  . LEU A 1 76  ? 16.101 -20.308 0.984   1.00 23.19  ? 76  LEU A CA  1 
ATOM   545  C C   . LEU A 1 76  ? 15.468 -19.127 1.700   1.00 23.84  ? 76  LEU A C   1 
ATOM   546  O O   . LEU A 1 76  ? 14.506 -18.536 1.201   1.00 24.07  ? 76  LEU A O   1 
ATOM   547  C CB  . LEU A 1 76  ? 17.005 -19.818 -0.151  1.00 23.80  ? 76  LEU A CB  1 
ATOM   548  C CG  . LEU A 1 76  ? 18.247 -19.014 0.254   1.00 24.19  ? 76  LEU A CG  1 
ATOM   549  C CD1 . LEU A 1 76  ? 19.246 -19.896 0.992   1.00 25.28  ? 76  LEU A CD1 1 
ATOM   550  C CD2 . LEU A 1 76  ? 18.905 -18.384 -0.967  1.00 25.18  ? 76  LEU A CD2 1 
ATOM   551  N N   . VAL A 1 77  ? 16.017 -18.782 2.859   1.00 25.85  ? 77  VAL A N   1 
ATOM   552  C CA  . VAL A 1 77  ? 15.420 -17.787 3.741   1.00 26.44  ? 77  VAL A CA  1 
ATOM   553  C C   . VAL A 1 77  ? 16.466 -16.779 4.213   1.00 25.32  ? 77  VAL A C   1 
ATOM   554  O O   . VAL A 1 77  ? 17.580 -17.155 4.577   1.00 26.18  ? 77  VAL A O   1 
ATOM   555  C CB  . VAL A 1 77  ? 14.806 -18.470 4.982   1.00 29.93  ? 77  VAL A CB  1 
ATOM   556  C CG1 . VAL A 1 77  ? 14.306 -17.441 5.984   1.00 33.26  ? 77  VAL A CG1 1 
ATOM   557  C CG2 . VAL A 1 77  ? 13.684 -19.419 4.574   1.00 29.74  ? 77  VAL A CG2 1 
ATOM   558  N N   . VAL A 1 78  ? 16.091 -15.502 4.200   1.00 26.48  ? 78  VAL A N   1 
ATOM   559  C CA  . VAL A 1 78  ? 16.844 -14.465 4.897   1.00 28.08  ? 78  VAL A CA  1 
ATOM   560  C C   . VAL A 1 78  ? 15.908 -13.762 5.879   1.00 28.00  ? 78  VAL A C   1 
ATOM   561  O O   . VAL A 1 78  ? 14.772 -13.423 5.533   1.00 28.11  ? 78  VAL A O   1 
ATOM   562  C CB  . VAL A 1 78  ? 17.512 -13.453 3.930   1.00 28.69  ? 78  VAL A CB  1 
ATOM   563  C CG1 . VAL A 1 78  ? 16.485 -12.695 3.098   1.00 29.55  ? 78  VAL A CG1 1 
ATOM   564  C CG2 . VAL A 1 78  ? 18.398 -12.477 4.696   1.00 30.22  ? 78  VAL A CG2 1 
ATOM   565  N N   . HIS A 1 79  ? 16.379 -13.579 7.109   1.00 30.88  ? 79  HIS A N   1 
ATOM   566  C CA  . HIS A 1 79  ? 15.635 -12.836 8.122   1.00 35.85  ? 79  HIS A CA  1 
ATOM   567  C C   . HIS A 1 79  ? 15.684 -11.353 7.800   1.00 34.27  ? 79  HIS A C   1 
ATOM   568  O O   . HIS A 1 79  ? 16.767 -10.778 7.688   1.00 35.56  ? 79  HIS A O   1 
ATOM   569  C CB  . HIS A 1 79  ? 16.221 -13.076 9.515   1.00 38.95  ? 79  HIS A CB  1 
ATOM   570  C CG  . HIS A 1 79  ? 15.820 -14.383 10.122  1.00 41.32  ? 79  HIS A CG  1 
ATOM   571  N ND1 . HIS A 1 79  ? 15.284 -14.480 11.388  1.00 46.56  ? 79  HIS A ND1 1 
ATOM   572  C CD2 . HIS A 1 79  ? 15.863 -15.644 9.633   1.00 42.92  ? 79  HIS A CD2 1 
ATOM   573  C CE1 . HIS A 1 79  ? 15.023 -15.747 11.656  1.00 49.05  ? 79  HIS A CE1 1 
ATOM   574  N NE2 . HIS A 1 79  ? 15.365 -16.474 10.608  1.00 47.02  ? 79  HIS A NE2 1 
ATOM   575  N N   . GLU A 1 80  ? 14.514 -10.739 7.646   1.00 37.63  ? 80  GLU A N   1 
ATOM   576  C CA  . GLU A 1 80  ? 14.436 -9.305  7.366   1.00 37.49  ? 80  GLU A CA  1 
ATOM   577  C C   . GLU A 1 80  ? 14.803 -8.474  8.593   1.00 39.39  ? 80  GLU A C   1 
ATOM   578  O O   . GLU A 1 80  ? 15.306 -7.363  8.462   1.00 41.16  ? 80  GLU A O   1 
ATOM   579  C CB  . GLU A 1 80  ? 13.043 -8.926  6.861   1.00 38.63  ? 80  GLU A CB  1 
ATOM   580  C CG  . GLU A 1 80  ? 12.672 -9.624  5.561   1.00 40.62  ? 80  GLU A CG  1 
ATOM   581  C CD  . GLU A 1 80  ? 11.443 -9.037  4.891   1.00 45.67  ? 80  GLU A CD  1 
ATOM   582  O OE1 . GLU A 1 80  ? 10.753 -8.194  5.508   1.00 49.52  ? 80  GLU A OE1 1 
ATOM   583  O OE2 . GLU A 1 80  ? 11.169 -9.425  3.737   1.00 46.91  ? 80  GLU A OE2 1 
ATOM   584  N N   . LYS A 1 81  ? 14.547 -9.017  9.781   1.00 42.94  ? 81  LYS A N   1 
ATOM   585  C CA  . LYS A 1 81  ? 14.947 -8.375  11.029  1.00 44.06  ? 81  LYS A CA  1 
ATOM   586  C C   . LYS A 1 81  ? 16.443 -8.594  11.256  1.00 42.58  ? 81  LYS A C   1 
ATOM   587  O O   . LYS A 1 81  ? 16.915 -9.728  11.251  1.00 40.82  ? 81  LYS A O   1 
ATOM   588  C CB  . LYS A 1 81  ? 14.143 -8.943  12.200  1.00 50.99  ? 81  LYS A CB  1 
ATOM   589  C CG  . LYS A 1 81  ? 14.307 -8.175  13.500  1.00 57.88  ? 81  LYS A CG  1 
ATOM   590  C CD  . LYS A 1 81  ? 13.381 -8.711  14.581  1.00 63.15  ? 81  LYS A CD  1 
ATOM   591  C CE  . LYS A 1 81  ? 13.459 -7.875  15.850  1.00 67.11  ? 81  LYS A CE  1 
ATOM   592  N NZ  . LYS A 1 81  ? 14.807 -7.914  16.484  1.00 68.34  ? 81  LYS A NZ  1 
ATOM   593  N N   . ALA A 1 82  ? 17.183 -7.505  11.445  1.00 43.58  ? 82  ALA A N   1 
ATOM   594  C CA  . ALA A 1 82  ? 18.631 -7.587  11.668  1.00 42.68  ? 82  ALA A CA  1 
ATOM   595  C C   . ALA A 1 82  ? 18.942 -8.161  13.050  1.00 47.75  ? 82  ALA A C   1 
ATOM   596  O O   . ALA A 1 82  ? 18.144 -8.029  13.981  1.00 52.44  ? 82  ALA A O   1 
ATOM   597  C CB  . ALA A 1 82  ? 19.279 -6.218  11.504  1.00 41.82  ? 82  ALA A CB  1 
ATOM   598  N N   . GLY A 1 83  ? 20.097 -8.808  13.171  1.00 49.00  ? 83  GLY A N   1 
ATOM   599  C CA  . GLY A 1 83  ? 20.524 -9.403  14.437  1.00 58.41  ? 83  GLY A CA  1 
ATOM   600  C C   . GLY A 1 83  ? 20.093 -10.851 14.571  1.00 62.53  ? 83  GLY A C   1 
ATOM   601  O O   . GLY A 1 83  ? 19.164 -11.300 13.900  1.00 61.45  ? 83  GLY A O   1 
ATOM   602  N N   . ALA A 1 84  ? 20.763 -11.573 15.465  1.00 66.71  ? 84  ALA A N   1 
ATOM   603  C CA  . ALA A 1 84  ? 20.562 -13.015 15.627  1.00 71.58  ? 84  ALA A CA  1 
ATOM   604  C C   . ALA A 1 84  ? 19.219 -13.355 16.281  1.00 77.19  ? 84  ALA A C   1 
ATOM   605  O O   . ALA A 1 84  ? 18.426 -12.466 16.603  1.00 72.42  ? 84  ALA A O   1 
ATOM   606  C CB  . ALA A 1 84  ? 21.711 -13.611 16.432  1.00 74.94  ? 84  ALA A CB  1 
ATOM   607  N N   . GLY A 1 85  ? 18.972 -14.652 16.455  1.00 79.40  ? 85  GLY A N   1 
ATOM   608  C CA  . GLY A 1 85  ? 17.756 -15.142 17.098  1.00 80.98  ? 85  GLY A CA  1 
ATOM   609  C C   . GLY A 1 85  ? 16.650 -15.441 16.104  1.00 85.20  ? 85  GLY A C   1 
ATOM   610  O O   . GLY A 1 85  ? 16.897 -15.588 14.904  1.00 85.33  ? 85  GLY A O   1 
ATOM   611  N N   . ALA A 1 86  ? 15.428 -15.539 16.616  1.00 83.15  ? 86  ALA A N   1 
ATOM   612  C CA  . ALA A 1 86  ? 14.260 -15.819 15.792  1.00 81.22  ? 86  ALA A CA  1 
ATOM   613  C C   . ALA A 1 86  ? 13.809 -14.572 15.040  1.00 80.90  ? 86  ALA A C   1 
ATOM   614  O O   . ALA A 1 86  ? 14.251 -13.456 15.327  1.00 84.75  ? 86  ALA A O   1 
ATOM   615  C CB  . ALA A 1 86  ? 13.124 -16.346 16.656  1.00 80.32  ? 86  ALA A CB  1 
ATOM   616  N N   . GLY A 1 87  ? 12.922 -14.779 14.076  1.00 75.48  ? 87  GLY A N   1 
ATOM   617  C CA  . GLY A 1 87  ? 12.301 -13.684 13.346  1.00 72.13  ? 87  GLY A CA  1 
ATOM   618  C C   . GLY A 1 87  ? 11.291 -14.243 12.367  1.00 69.35  ? 87  GLY A C   1 
ATOM   619  O O   . GLY A 1 87  ? 11.597 -15.182 11.636  1.00 73.93  ? 87  GLY A O   1 
ATOM   620  N N   . SER A 1 88  ? 10.091 -13.673 12.345  1.00 65.24  ? 88  SER A N   1 
ATOM   621  C CA  . SER A 1 88  ? 9.023  -14.191 11.491  1.00 62.86  ? 88  SER A CA  1 
ATOM   622  C C   . SER A 1 88  ? 8.925  -13.478 10.141  1.00 57.12  ? 88  SER A C   1 
ATOM   623  O O   . SER A 1 88  ? 8.333  -14.017 9.210   1.00 51.38  ? 88  SER A O   1 
ATOM   624  C CB  . SER A 1 88  ? 7.680  -14.138 12.221  1.00 63.93  ? 88  SER A CB  1 
ATOM   625  O OG  . SER A 1 88  ? 7.062  -12.870 12.084  1.00 67.53  ? 88  SER A OG  1 
ATOM   626  N N   . ARG A 1 89  ? 9.490  -12.273 10.041  1.00 53.33  ? 89  ARG A N   1 
ATOM   627  C CA  . ARG A 1 89  ? 9.531  -11.533 8.774   1.00 50.66  ? 89  ARG A CA  1 
ATOM   628  C C   . ARG A 1 89  ? 10.659 -12.058 7.890   1.00 41.90  ? 89  ARG A C   1 
ATOM   629  O O   . ARG A 1 89  ? 11.837 -11.800 8.151   1.00 39.69  ? 89  ARG A O   1 
ATOM   630  C CB  . ARG A 1 89  ? 9.716  -10.032 9.020   1.00 56.35  ? 89  ARG A CB  1 
ATOM   631  C CG  . ARG A 1 89  ? 8.480  -9.336  9.568   1.00 64.37  ? 89  ARG A CG  1 
ATOM   632  C CD  . ARG A 1 89  ? 7.475  -9.006  8.472   1.00 72.65  ? 89  ARG A CD  1 
ATOM   633  N NE  . ARG A 1 89  ? 7.945  -7.932  7.597   1.00 79.19  ? 89  ARG A NE  1 
ATOM   634  C CZ  . ARG A 1 89  ? 7.269  -7.448  6.555   1.00 85.80  ? 89  ARG A CZ  1 
ATOM   635  N NH1 . ARG A 1 89  ? 6.072  -7.934  6.234   1.00 90.97  ? 89  ARG A NH1 1 
ATOM   636  N NH2 . ARG A 1 89  ? 7.794  -6.468  5.827   1.00 89.20  ? 89  ARG A NH2 1 
ATOM   637  N N   . LEU A 1 90  ? 10.288 -12.787 6.840   1.00 43.02  ? 90  LEU A N   1 
ATOM   638  C CA  . LEU A 1 90  ? 11.255 -13.443 5.966   1.00 39.93  ? 90  LEU A CA  1 
ATOM   639  C C   . LEU A 1 90  ? 11.118 -12.989 4.521   1.00 33.87  ? 90  LEU A C   1 
ATOM   640  O O   . LEU A 1 90  ? 10.007 -12.788 4.027   1.00 36.30  ? 90  LEU A O   1 
ATOM   641  C CB  . LEU A 1 90  ? 11.045 -14.958 5.992   1.00 40.17  ? 90  LEU A CB  1 
ATOM   642  C CG  . LEU A 1 90  ? 10.896 -15.664 7.338   1.00 40.91  ? 90  LEU A CG  1 
ATOM   643  C CD1 . LEU A 1 90  ? 10.615 -17.137 7.091   1.00 41.90  ? 90  LEU A CD1 1 
ATOM   644  C CD2 . LEU A 1 90  ? 12.133 -15.478 8.208   1.00 39.60  ? 90  LEU A CD2 1 
ATOM   645  N N   . ALA A 1 91  ? 12.253 -12.832 3.849   1.00 30.74  ? 91  ALA A N   1 
ATOM   646  C CA  . ALA A 1 91  ? 12.280 -12.870 2.395   1.00 29.10  ? 91  ALA A CA  1 
ATOM   647  C C   . ALA A 1 91  ? 12.736 -14.274 2.025   1.00 27.05  ? 91  ALA A C   1 
ATOM   648  O O   . ALA A 1 91  ? 13.670 -14.804 2.628   1.00 29.58  ? 91  ALA A O   1 
ATOM   649  C CB  . ALA A 1 91  ? 13.218 -11.817 1.833   1.00 26.92  ? 91  ALA A CB  1 
ATOM   650  N N   . SER A 1 92  ? 12.065 -14.894 1.062   1.00 23.97  ? 92  SER A N   1 
ATOM   651  C CA  . SER A 1 92  ? 12.344 -16.292 0.755   1.00 26.79  ? 92  SER A CA  1 
ATOM   652  C C   . SER A 1 92  ? 12.072 -16.665 -0.690  1.00 24.62  ? 92  SER A C   1 
ATOM   653  O O   . SER A 1 92  ? 11.427 -15.931 -1.433  1.00 27.35  ? 92  SER A O   1 
ATOM   654  C CB  . SER A 1 92  ? 11.548 -17.208 1.688   1.00 25.34  ? 92  SER A CB  1 
ATOM   655  O OG  . SER A 1 92  ? 10.165 -17.138 1.409   1.00 27.68  ? 92  SER A OG  1 
ATOM   656  N N   . GLY A 1 93  ? 12.590 -17.821 -1.079  1.00 24.02  ? 93  GLY A N   1 
ATOM   657  C CA  . GLY A 1 93  ? 12.385 -18.335 -2.420  1.00 24.90  ? 93  GLY A CA  1 
ATOM   658  C C   . GLY A 1 93  ? 12.824 -19.774 -2.522  1.00 24.30  ? 93  GLY A C   1 
ATOM   659  O O   . GLY A 1 93  ? 13.749 -20.200 -1.829  1.00 27.01  ? 93  GLY A O   1 
ATOM   660  N N   . VAL A 1 94  ? 12.162 -20.519 -3.398  1.00 23.33  ? 94  VAL A N   1 
ATOM   661  C CA  . VAL A 1 94  ? 12.477 -21.924 -3.600  1.00 22.85  ? 94  VAL A CA  1 
ATOM   662  C C   . VAL A 1 94  ? 13.741 -22.029 -4.452  1.00 24.28  ? 94  VAL A C   1 
ATOM   663  O O   . VAL A 1 94  ? 13.915 -21.294 -5.425  1.00 25.21  ? 94  VAL A O   1 
ATOM   664  C CB  . VAL A 1 94  ? 11.305 -22.675 -4.265  1.00 23.03  ? 94  VAL A CB  1 
ATOM   665  C CG1 . VAL A 1 94  ? 11.644 -24.143 -4.474  1.00 23.81  ? 94  VAL A CG1 1 
ATOM   666  C CG2 . VAL A 1 94  ? 10.044 -22.549 -3.416  1.00 26.28  ? 94  VAL A CG2 1 
ATOM   667  N N   . ILE A 1 95  ? 14.624 -22.943 -4.070  1.00 24.45  ? 95  ILE A N   1 
ATOM   668  C CA  . ILE A 1 95  ? 15.864 -23.159 -4.805  1.00 26.98  ? 95  ILE A CA  1 
ATOM   669  C C   . ILE A 1 95  ? 15.552 -24.014 -6.034  1.00 25.08  ? 95  ILE A C   1 
ATOM   670  O O   . ILE A 1 95  ? 15.205 -25.193 -5.912  1.00 26.63  ? 95  ILE A O   1 
ATOM   671  C CB  . ILE A 1 95  ? 16.926 -23.836 -3.920  1.00 28.59  ? 95  ILE A CB  1 
ATOM   672  C CG1 . ILE A 1 95  ? 17.226 -22.952 -2.701  1.00 24.55  ? 95  ILE A CG1 1 
ATOM   673  C CG2 . ILE A 1 95  ? 18.196 -24.104 -4.721  1.00 27.05  ? 95  ILE A CG2 1 
ATOM   674  C CD1 . ILE A 1 95  ? 17.940 -23.661 -1.572  1.00 24.28  ? 95  ILE A CD1 1 
ATOM   675  N N   . GLY A 1 96  ? 15.663 -23.406 -7.212  1.00 26.12  ? 96  GLY A N   1 
ATOM   676  C CA  . GLY A 1 96  ? 15.317 -24.063 -8.467  1.00 26.65  ? 96  GLY A CA  1 
ATOM   677  C C   . GLY A 1 96  ? 16.531 -24.416 -9.303  1.00 27.14  ? 96  GLY A C   1 
ATOM   678  O O   . GLY A 1 96  ? 17.572 -23.760 -9.216  1.00 26.90  ? 96  GLY A O   1 
ATOM   679  N N   . ILE A 1 97  ? 16.379 -25.434 -10.141 1.00 31.43  ? 97  ILE A N   1 
ATOM   680  C CA  . ILE A 1 97  ? 17.461 -25.925 -10.980 1.00 33.30  ? 97  ILE A CA  1 
ATOM   681  C C   . ILE A 1 97  ? 17.665 -25.016 -12.167 1.00 34.54  ? 97  ILE A C   1 
ATOM   682  O O   . ILE A 1 97  ? 16.707 -24.666 -12.842 1.00 37.74  ? 97  ILE A O   1 
ATOM   683  C CB  . ILE A 1 97  ? 17.165 -27.348 -11.504 1.00 37.10  ? 97  ILE A CB  1 
ATOM   684  C CG1 . ILE A 1 97  ? 16.940 -28.299 -10.340 1.00 41.33  ? 97  ILE A CG1 1 
ATOM   685  C CG2 . ILE A 1 97  ? 18.321 -27.873 -12.345 1.00 40.40  ? 97  ILE A CG2 1 
ATOM   686  C CD1 . ILE A 1 97  ? 18.152 -28.411 -9.455  1.00 43.44  ? 97  ILE A CD1 1 
ATOM   687  N N   . ALA A 1 98  ? 18.918 -24.646 -12.420 1.00 37.62  ? 98  ALA A N   1 
ATOM   688  C CA  . ALA A 1 98  ? 19.276 -23.833 -13.582 1.00 41.68  ? 98  ALA A CA  1 
ATOM   689  C C   . ALA A 1 98  ? 19.906 -24.707 -14.662 1.00 45.97  ? 98  ALA A C   1 
ATOM   690  O O   . ALA A 1 98  ? 19.496 -24.667 -15.823 1.00 44.99  ? 98  ALA A O   1 
ATOM   691  C CB  . ALA A 1 98  ? 20.235 -22.728 -13.175 1.00 40.63  ? 98  ALA A CB  1 
ATOM   692  N N   . GLN A 1 99  ? 20.911 -25.483 -14.263 1.00 48.59  ? 99  GLN A N   1 
ATOM   693  C CA  . GLN A 1 99  ? 21.594 -26.425 -15.151 1.00 54.35  ? 99  GLN A CA  1 
ATOM   694  C C   . GLN A 1 99  ? 21.885 -27.720 -14.398 1.00 56.54  ? 99  GLN A C   1 
ATOM   695  O O   . GLN A 1 99  ? 22.063 -27.709 -13.178 1.00 48.25  ? 99  GLN A O   1 
ATOM   696  C CB  . GLN A 1 99  ? 22.900 -25.820 -15.679 1.00 60.79  ? 99  GLN A CB  1 
ATOM   697  C CG  . GLN A 1 99  ? 22.721 -24.812 -16.807 1.00 68.76  ? 99  GLN A CG  1 
ATOM   698  C CD  . GLN A 1 99  ? 22.329 -25.458 -18.128 1.00 72.60  ? 99  GLN A CD  1 
ATOM   699  O OE1 . GLN A 1 99  ? 22.801 -26.543 -18.467 1.00 74.72  ? 99  GLN A OE1 1 
ATOM   700  N NE2 . GLN A 1 99  ? 21.465 -24.786 -18.885 1.00 77.76  ? 99  GLN A NE2 1 
ATOM   701  N N   . ALA A 1 100 ? 21.927 -28.831 -15.129 1.00 60.64  ? 100 ALA A N   1 
ATOM   702  C CA  . ALA A 1 100 ? 22.178 -30.140 -14.530 1.00 67.74  ? 100 ALA A CA  1 
ATOM   703  C C   . ALA A 1 100 ? 22.693 -31.138 -15.566 1.00 76.13  ? 100 ALA A C   1 
ATOM   704  O O   . ALA A 1 100 ? 22.093 -31.300 -16.631 1.00 76.59  ? 100 ALA A O   1 
ATOM   705  C CB  . ALA A 1 100 ? 20.911 -30.668 -13.875 1.00 70.98  ? 100 ALA A CB  1 
ATOM   706  N N   . GLY A 1 101 ? 23.805 -31.796 -15.243 1.00 82.53  ? 101 GLY A N   1 
ATOM   707  C CA  . GLY A 1 101 ? 24.389 -32.834 -16.095 1.00 87.79  ? 101 GLY A CA  1 
ATOM   708  C C   . GLY A 1 101 ? 25.762 -32.439 -16.624 1.00 91.87  ? 101 GLY A C   1 
ATOM   709  O O   . GLY A 1 101 ? 25.958 -31.283 -17.002 1.00 89.78  ? 101 GLY A O   1 
ATOM   710  N N   . ALA A 1 102 ? 26.725 -33.364 -16.658 1.00 96.37  ? 102 ALA A N   1 
ATOM   711  C CA  . ALA A 1 102 ? 26.574 -34.736 -16.160 1.00 99.91  ? 102 ALA A CA  1 
ATOM   712  C C   . ALA A 1 102 ? 26.757 -34.754 -14.646 1.00 89.41  ? 102 ALA A C   1 
ATOM   713  O O   . ALA A 1 102 ? 25.863 -35.171 -13.907 1.00 90.17  ? 102 ALA A O   1 
ATOM   714  C CB  . ALA A 1 102 ? 27.585 -35.657 -16.827 1.00 97.97  ? 102 ALA A CB  1 
ATOM   715  N N   . GLY A 1 103 ? 27.918 -34.288 -14.195 1.00 83.26  ? 103 GLY A N   1 
ATOM   716  C CA  . GLY A 1 103 ? 28.217 -34.175 -12.769 1.00 80.43  ? 103 GLY A CA  1 
ATOM   717  C C   . GLY A 1 103 ? 27.869 -32.809 -12.202 1.00 75.75  ? 103 GLY A C   1 
ATOM   718  O O   . GLY A 1 103 ? 27.425 -32.703 -11.057 1.00 73.55  ? 103 GLY A O   1 
ATOM   719  N N   . ALA A 1 104 ? 28.067 -31.764 -13.006 1.00 68.14  ? 104 ALA A N   1 
ATOM   720  C CA  . ALA A 1 104 ? 27.890 -30.379 -12.554 1.00 60.57  ? 104 ALA A CA  1 
ATOM   721  C C   . ALA A 1 104 ? 26.419 -29.976 -12.412 1.00 56.91  ? 104 ALA A C   1 
ATOM   722  O O   . ALA A 1 104 ? 25.548 -30.481 -13.124 1.00 55.09  ? 104 ALA A O   1 
ATOM   723  C CB  . ALA A 1 104 ? 28.607 -29.422 -13.497 1.00 66.34  ? 104 ALA A CB  1 
ATOM   724  N N   . THR A 1 105 ? 26.160 -29.056 -11.486 1.00 48.63  ? 105 THR A N   1 
ATOM   725  C CA  . THR A 1 105 ? 24.809 -28.561 -11.225 1.00 41.25  ? 105 THR A CA  1 
ATOM   726  C C   . THR A 1 105 ? 24.850 -27.077 -10.877 1.00 37.67  ? 105 THR A C   1 
ATOM   727  O O   . THR A 1 105 ? 25.769 -26.618 -10.196 1.00 39.34  ? 105 THR A O   1 
ATOM   728  C CB  . THR A 1 105 ? 24.146 -29.313 -10.052 1.00 45.52  ? 105 THR A CB  1 
ATOM   729  O OG1 . THR A 1 105 ? 24.448 -30.709 -10.135 1.00 51.05  ? 105 THR A OG1 1 
ATOM   730  C CG2 . THR A 1 105 ? 22.633 -29.128 -10.073 1.00 49.84  ? 105 THR A CG2 1 
ATOM   731  N N   . LYS A 1 106 ? 23.852 -26.337 -11.355 1.00 34.49  ? 106 LYS A N   1 
ATOM   732  C CA  . LYS A 1 106 ? 23.670 -24.936 -10.992 1.00 30.26  ? 106 LYS A CA  1 
ATOM   733  C C   . LYS A 1 106 ? 22.222 -24.724 -10.563 1.00 32.43  ? 106 LYS A C   1 
ATOM   734  O O   . LYS A 1 106 ? 21.309 -25.296 -11.160 1.00 33.33  ? 106 LYS A O   1 
ATOM   735  C CB  . LYS A 1 106 ? 24.010 -24.028 -12.173 1.00 33.25  ? 106 LYS A CB  1 
ATOM   736  C CG  . LYS A 1 106 ? 25.430 -24.204 -12.698 1.00 36.57  ? 106 LYS A CG  1 
ATOM   737  C CD  . LYS A 1 106 ? 25.731 -23.231 -13.826 1.00 39.89  ? 106 LYS A CD  1 
ATOM   738  C CE  . LYS A 1 106 ? 27.072 -23.528 -14.482 1.00 43.73  ? 106 LYS A CE  1 
ATOM   739  N NZ  . LYS A 1 106 ? 28.218 -23.398 -13.537 1.00 48.65  ? 106 LYS A NZ  1 
ATOM   740  N N   . ALA A 1 107 ? 22.019 -23.908 -9.530  1.00 31.81  ? 107 ALA A N   1 
ATOM   741  C CA  . ALA A 1 107 ? 20.673 -23.599 -9.031  1.00 25.96  ? 107 ALA A CA  1 
ATOM   742  C C   . ALA A 1 107 ? 20.542 -22.123 -8.678  1.00 25.06  ? 107 ALA A C   1 
ATOM   743  O O   . ALA A 1 107 ? 21.540 -21.456 -8.394  1.00 27.97  ? 107 ALA A O   1 
ATOM   744  C CB  . ALA A 1 107 ? 20.350 -24.458 -7.820  1.00 31.10  ? 107 ALA A CB  1 
ATOM   745  N N   . VAL A 1 108 ? 19.308 -21.619 -8.700  1.00 24.85  ? 108 VAL A N   1 
ATOM   746  C CA  . VAL A 1 108 ? 19.030 -20.217 -8.387  1.00 25.43  ? 108 VAL A CA  1 
ATOM   747  C C   . VAL A 1 108 ? 17.813 -20.084 -7.469  1.00 25.35  ? 108 VAL A C   1 
ATOM   748  O O   . VAL A 1 108 ? 16.794 -20.746 -7.675  1.00 26.25  ? 108 VAL A O   1 
ATOM   749  C CB  . VAL A 1 108 ? 18.776 -19.373 -9.658  1.00 27.74  ? 108 VAL A CB  1 
ATOM   750  C CG1 . VAL A 1 108 ? 18.709 -17.890 -9.312  1.00 25.73  ? 108 VAL A CG1 1 
ATOM   751  C CG2 . VAL A 1 108 ? 19.862 -19.604 -10.698 1.00 30.62  ? 108 VAL A CG2 1 
ATOM   752  N N   . ALA A 1 109 ? 17.937 -19.227 -6.458  1.00 25.78  ? 109 ALA A N   1 
ATOM   753  C CA  . ALA A 1 109 ? 16.809 -18.844 -5.609  1.00 23.52  ? 109 ALA A CA  1 
ATOM   754  C C   . ALA A 1 109 ? 16.532 -17.351 -5.765  1.00 23.24  ? 109 ALA A C   1 
ATOM   755  O O   . ALA A 1 109 ? 17.419 -16.513 -5.541  1.00 24.04  ? 109 ALA A O   1 
ATOM   756  C CB  . ALA A 1 109 ? 17.094 -19.180 -4.156  1.00 27.42  ? 109 ALA A CB  1 
ATOM   757  N N   . VAL A 1 110 ? 15.309 -17.025 -6.174  1.00 23.99  ? 110 VAL A N   1 
ATOM   758  C CA  . VAL A 1 110 ? 14.845 -15.645 -6.240  1.00 25.12  ? 110 VAL A CA  1 
ATOM   759  C C   . VAL A 1 110 ? 14.163 -15.318 -4.912  1.00 24.14  ? 110 VAL A C   1 
ATOM   760  O O   . VAL A 1 110 ? 13.104 -15.871 -4.605  1.00 26.27  ? 110 VAL A O   1 
ATOM   761  C CB  . VAL A 1 110 ? 13.844 -15.430 -7.401  1.00 25.99  ? 110 VAL A CB  1 
ATOM   762  C CG1 . VAL A 1 110 ? 13.363 -13.982 -7.442  1.00 25.25  ? 110 VAL A CG1 1 
ATOM   763  C CG2 . VAL A 1 110 ? 14.464 -15.819 -8.737  1.00 28.27  ? 110 VAL A CG2 1 
ATOM   764  N N   . LEU A 1 111 ? 14.772 -14.438 -4.126  1.00 24.63  ? 111 LEU A N   1 
ATOM   765  C CA  . LEU A 1 111 ? 14.248 -14.073 -2.819  1.00 23.83  ? 111 LEU A CA  1 
ATOM   766  C C   . LEU A 1 111 ? 13.282 -12.902 -2.898  1.00 25.38  ? 111 LEU A C   1 
ATOM   767  O O   . LEU A 1 111 ? 13.624 -11.852 -3.438  1.00 27.49  ? 111 LEU A O   1 
ATOM   768  C CB  . LEU A 1 111 ? 15.374 -13.686 -1.872  1.00 23.95  ? 111 LEU A CB  1 
ATOM   769  C CG  . LEU A 1 111 ? 16.483 -14.688 -1.555  1.00 24.89  ? 111 LEU A CG  1 
ATOM   770  C CD1 . LEU A 1 111 ? 17.257 -14.204 -0.345  1.00 26.28  ? 111 LEU A CD1 1 
ATOM   771  C CD2 . LEU A 1 111 ? 15.925 -16.063 -1.285  1.00 26.67  ? 111 LEU A CD2 1 
ATOM   772  N N   . LYS A 1 112 ? 12.095 -13.079 -2.322  1.00 27.73  ? 112 LYS A N   1 
ATOM   773  C CA  . LYS A 1 112 ? 11.094 -12.021 -2.259  1.00 31.78  ? 112 LYS A CA  1 
ATOM   774  C C   . LYS A 1 112 ? 10.477 -12.000 -0.863  1.00 33.33  ? 112 LYS A C   1 
ATOM   775  O O   . LYS A 1 112 ? 10.189 -13.051 -0.291  1.00 29.97  ? 112 LYS A O   1 
ATOM   776  C CB  . LYS A 1 112 ? 10.010 -12.254 -3.313  1.00 37.14  ? 112 LYS A CB  1 
ATOM   777  C CG  . LYS A 1 112 ? 9.150  -11.034 -3.608  1.00 42.76  ? 112 LYS A CG  1 
ATOM   778  C CD  . LYS A 1 112 ? 7.842  -11.433 -4.281  1.00 50.63  ? 112 LYS A CD  1 
ATOM   779  C CE  . LYS A 1 112 ? 7.001  -10.223 -4.661  1.00 59.33  ? 112 LYS A CE  1 
ATOM   780  N NZ  . LYS A 1 112 ? 7.531  -9.508  -5.857  1.00 64.66  ? 112 LYS A NZ  1 
ATOM   781  N N   . GLY A 1 113 ? 10.285 -10.800 -0.322  1.00 37.10  ? 113 GLY A N   1 
ATOM   782  C CA  . GLY A 1 113 ? 9.686  -10.628 0.998   1.00 43.30  ? 113 GLY A CA  1 
ATOM   783  C C   . GLY A 1 113 ? 8.248  -10.167 0.889   1.00 51.50  ? 113 GLY A C   1 
ATOM   784  O O   . GLY A 1 113 ? 7.516  -10.606 0.000   1.00 54.67  ? 113 GLY A O   1 
ATOM   785  N N   . ASP A 1 114 ? 7.851  -9.280  1.800   1.00 63.20  ? 114 ASP A N   1 
ATOM   786  C CA  . ASP A 1 114 ? 6.539  -8.626  1.759   1.00 70.06  ? 114 ASP A CA  1 
ATOM   787  C C   . ASP A 1 114 ? 6.660  -7.178  2.234   1.00 78.81  ? 114 ASP A C   1 
ATOM   788  O O   . ASP A 1 114 ? 7.417  -6.883  3.159   1.00 78.54  ? 114 ASP A O   1 
ATOM   789  C CB  . ASP A 1 114 ? 5.526  -9.376  2.631   1.00 76.92  ? 114 ASP A CB  1 
ATOM   790  C CG  . ASP A 1 114 ? 5.007  -10.642 1.972   1.00 77.74  ? 114 ASP A CG  1 
ATOM   791  O OD1 . ASP A 1 114 ? 4.587  -10.577 0.797   1.00 82.62  ? 114 ASP A OD1 1 
ATOM   792  O OD2 . ASP A 1 114 ? 5.008  -11.702 2.634   1.00 77.78  ? 114 ASP A OD2 1 
ATOM   793  N N   . GLY A 1 115 ? 5.910  -6.283  1.595   1.00 87.29  ? 115 GLY A N   1 
ATOM   794  C CA  . GLY A 1 115 ? 5.922  -4.863  1.950   1.00 93.50  ? 115 GLY A CA  1 
ATOM   795  C C   . GLY A 1 115 ? 5.360  -3.975  0.854   1.00 96.79  ? 115 GLY A C   1 
ATOM   796  O O   . GLY A 1 115 ? 5.668  -2.784  0.782   1.00 94.54  ? 115 GLY A O   1 
ATOM   797  O OXT . GLY A 1 115 ? 4.583  -4.421  0.009   1.00 102.54 ? 115 GLY A OXT 1 
ATOM   798  N N   . ALA B 1 1   ? 4.480  -9.878  -23.995 1.00 81.58  ? 1   ALA B N   1 
ATOM   799  C CA  . ALA B 1 1   ? 5.227  -10.092 -22.716 1.00 76.61  ? 1   ALA B CA  1 
ATOM   800  C C   . ALA B 1 1   ? 6.538  -9.298  -22.707 1.00 75.73  ? 1   ALA B C   1 
ATOM   801  O O   . ALA B 1 1   ? 7.301  -9.368  -23.672 1.00 72.66  ? 1   ALA B O   1 
ATOM   802  C CB  . ALA B 1 1   ? 5.510  -11.573 -22.513 1.00 75.77  ? 1   ALA B CB  1 
ATOM   803  N N   . PRO B 1 2   ? 6.802  -8.537  -21.625 1.00 68.82  ? 2   PRO B N   1 
ATOM   804  C CA  . PRO B 1 2   ? 8.103  -7.873  -21.516 1.00 63.18  ? 2   PRO B CA  1 
ATOM   805  C C   . PRO B 1 2   ? 9.234  -8.883  -21.337 1.00 56.10  ? 2   PRO B C   1 
ATOM   806  O O   . PRO B 1 2   ? 9.145  -9.761  -20.475 1.00 61.71  ? 2   PRO B O   1 
ATOM   807  C CB  . PRO B 1 2   ? 7.964  -7.000  -20.258 1.00 67.15  ? 2   PRO B CB  1 
ATOM   808  C CG  . PRO B 1 2   ? 6.505  -6.912  -19.985 1.00 68.31  ? 2   PRO B CG  1 
ATOM   809  C CD  . PRO B 1 2   ? 5.911  -8.182  -20.507 1.00 72.46  ? 2   PRO B CD  1 
ATOM   810  N N   . VAL B 1 3   ? 10.278 -8.765  -22.153 1.00 46.35  ? 3   VAL B N   1 
ATOM   811  C CA  . VAL B 1 3   ? 11.426 -9.663  -22.062 1.00 43.30  ? 3   VAL B CA  1 
ATOM   812  C C   . VAL B 1 3   ? 12.245 -9.335  -20.814 1.00 38.62  ? 3   VAL B C   1 
ATOM   813  O O   . VAL B 1 3   ? 12.585 -8.177  -20.571 1.00 36.98  ? 3   VAL B O   1 
ATOM   814  C CB  . VAL B 1 3   ? 12.317 -9.592  -23.321 1.00 44.10  ? 3   VAL B CB  1 
ATOM   815  C CG1 . VAL B 1 3   ? 13.581 -10.422 -23.140 1.00 42.68  ? 3   VAL B CG1 1 
ATOM   816  C CG2 . VAL B 1 3   ? 11.542 -10.073 -24.539 1.00 43.75  ? 3   VAL B CG2 1 
ATOM   817  N N   . GLN B 1 4   ? 12.538 -10.371 -20.032 1.00 37.70  ? 4   GLN B N   1 
ATOM   818  C CA  . GLN B 1 4   ? 13.292 -10.258 -18.785 1.00 35.21  ? 4   GLN B CA  1 
ATOM   819  C C   . GLN B 1 4   ? 14.286 -11.410 -18.723 1.00 31.48  ? 4   GLN B C   1 
ATOM   820  O O   . GLN B 1 4   ? 13.990 -12.519 -19.177 1.00 33.54  ? 4   GLN B O   1 
ATOM   821  C CB  . GLN B 1 4   ? 12.355 -10.349 -17.576 1.00 39.66  ? 4   GLN B CB  1 
ATOM   822  C CG  . GLN B 1 4   ? 11.406 -9.171  -17.396 1.00 42.83  ? 4   GLN B CG  1 
ATOM   823  C CD  . GLN B 1 4   ? 12.059 -7.954  -16.761 0.30 44.69  ? 4   GLN B CD  1 
ATOM   824  O OE1 . GLN B 1 4   ? 13.109 -8.051  -16.124 0.48 45.18  ? 4   GLN B OE1 1 
ATOM   825  N NE2 . GLN B 1 4   ? 11.426 -6.797  -16.921 0.77 46.78  ? 4   GLN B NE2 1 
ATOM   826  N N   . GLY B 1 5   ? 15.454 -11.162 -18.147 1.00 28.35  ? 5   GLY B N   1 
ATOM   827  C CA  . GLY B 1 5   ? 16.464 -12.208 -18.028 1.00 27.80  ? 5   GLY B CA  1 
ATOM   828  C C   . GLY B 1 5   ? 17.584 -11.859 -17.075 1.00 26.55  ? 5   GLY B C   1 
ATOM   829  O O   . GLY B 1 5   ? 17.831 -10.688 -16.794 1.00 28.12  ? 5   GLY B O   1 
ATOM   830  N N   . ILE B 1 6   ? 18.245 -12.891 -16.562 1.00 28.26  ? 6   ILE B N   1 
ATOM   831  C CA  . ILE B 1 6   ? 19.436 -12.723 -15.739 1.00 27.36  ? 6   ILE B CA  1 
ATOM   832  C C   . ILE B 1 6   ? 20.520 -13.635 -16.289 1.00 25.26  ? 6   ILE B C   1 
ATOM   833  O O   . ILE B 1 6   ? 20.359 -14.861 -16.301 1.00 27.57  ? 6   ILE B O   1 
ATOM   834  C CB  . ILE B 1 6   ? 19.172 -13.061 -14.260 1.00 29.25  ? 6   ILE B CB  1 
ATOM   835  C CG1 . ILE B 1 6   ? 18.025 -12.201 -13.722 1.00 30.55  ? 6   ILE B CG1 1 
ATOM   836  C CG2 . ILE B 1 6   ? 20.438 -12.834 -13.438 1.00 26.19  ? 6   ILE B CG2 1 
ATOM   837  C CD1 . ILE B 1 6   ? 17.499 -12.642 -12.378 1.00 35.21  ? 6   ILE B CD1 1 
ATOM   838  N N   . ILE B 1 7   ? 21.618 -13.029 -16.741 1.00 28.39  ? 7   ILE B N   1 
ATOM   839  C CA  . ILE B 1 7   ? 22.725 -13.758 -17.343 1.00 28.69  ? 7   ILE B CA  1 
ATOM   840  C C   . ILE B 1 7   ? 23.982 -13.561 -16.503 1.00 27.21  ? 7   ILE B C   1 
ATOM   841  O O   . ILE B 1 7   ? 24.419 -12.423 -16.258 1.00 26.54  ? 7   ILE B O   1 
ATOM   842  C CB  . ILE B 1 7   ? 22.984 -13.291 -18.789 1.00 29.76  ? 7   ILE B CB  1 
ATOM   843  C CG1 . ILE B 1 7   ? 21.712 -13.434 -19.641 1.00 26.76  ? 7   ILE B CG1 1 
ATOM   844  C CG2 . ILE B 1 7   ? 24.154 -14.052 -19.406 1.00 29.33  ? 7   ILE B CG2 1 
ATOM   845  C CD1 . ILE B 1 7   ? 21.185 -14.851 -19.783 1.00 26.79  ? 7   ILE B CD1 1 
ATOM   846  N N   . ASN B 1 8   ? 24.548 -14.678 -16.060 1.00 29.41  ? 8   ASN B N   1 
ATOM   847  C CA  . ASN B 1 8   ? 25.748 -14.682 -15.237 1.00 31.69  ? 8   ASN B CA  1 
ATOM   848  C C   . ASN B 1 8   ? 26.970 -14.978 -16.087 1.00 32.87  ? 8   ASN B C   1 
ATOM   849  O O   . ASN B 1 8   ? 26.874 -15.706 -17.074 1.00 40.36  ? 8   ASN B O   1 
ATOM   850  C CB  . ASN B 1 8   ? 25.613 -15.731 -14.134 1.00 32.58  ? 8   ASN B CB  1 
ATOM   851  C CG  . ASN B 1 8   ? 24.396 -15.493 -13.262 1.00 29.98  ? 8   ASN B CG  1 
ATOM   852  O OD1 . ASN B 1 8   ? 24.312 -14.481 -12.571 1.00 34.66  ? 8   ASN B OD1 1 
ATOM   853  N ND2 . ASN B 1 8   ? 23.442 -16.417 -13.296 1.00 28.79  ? 8   ASN B ND2 1 
ATOM   854  N N   . PHE B 1 9   ? 28.103 -14.394 -15.701 1.00 32.46  ? 9   PHE B N   1 
ATOM   855  C CA  . PHE B 1 9   ? 29.390 -14.621 -16.355 1.00 34.47  ? 9   PHE B CA  1 
ATOM   856  C C   . PHE B 1 9   ? 30.394 -15.045 -15.294 1.00 36.24  ? 9   PHE B C   1 
ATOM   857  O O   . PHE B 1 9   ? 30.434 -14.458 -14.207 1.00 44.58  ? 9   PHE B O   1 
ATOM   858  C CB  . PHE B 1 9   ? 29.893 -13.345 -17.035 1.00 37.46  ? 9   PHE B CB  1 
ATOM   859  C CG  . PHE B 1 9   ? 29.014 -12.861 -18.154 1.00 34.82  ? 9   PHE B CG  1 
ATOM   860  C CD1 . PHE B 1 9   ? 27.860 -12.134 -17.887 1.00 32.72  ? 9   PHE B CD1 1 
ATOM   861  C CD2 . PHE B 1 9   ? 29.341 -13.130 -19.475 1.00 36.76  ? 9   PHE B CD2 1 
ATOM   862  C CE1 . PHE B 1 9   ? 27.048 -11.687 -18.917 1.00 33.54  ? 9   PHE B CE1 1 
ATOM   863  C CE2 . PHE B 1 9   ? 28.534 -12.683 -20.509 1.00 32.65  ? 9   PHE B CE2 1 
ATOM   864  C CZ  . PHE B 1 9   ? 27.389 -11.962 -20.230 1.00 31.92  ? 9   PHE B CZ  1 
ATOM   865  N N   . GLU B 1 10  ? 31.196 -16.062 -15.605 1.00 39.12  ? 10  GLU B N   1 
ATOM   866  C CA  . GLU B 1 10  ? 32.208 -16.564 -14.675 1.00 43.16  ? 10  GLU B CA  1 
ATOM   867  C C   . GLU B 1 10  ? 33.490 -16.957 -15.396 1.00 47.84  ? 10  GLU B C   1 
ATOM   868  O O   . GLU B 1 10  ? 33.449 -17.633 -16.422 1.00 55.44  ? 10  GLU B O   1 
ATOM   869  C CB  . GLU B 1 10  ? 31.673 -17.771 -13.913 1.00 48.38  ? 10  GLU B CB  1 
ATOM   870  C CG  . GLU B 1 10  ? 30.550 -17.431 -12.955 1.00 48.76  ? 10  GLU B CG  1 
ATOM   871  C CD  . GLU B 1 10  ? 29.966 -18.659 -12.307 1.00 53.31  ? 10  GLU B CD  1 
ATOM   872  O OE1 . GLU B 1 10  ? 30.739 -19.443 -11.715 1.00 59.15  ? 10  GLU B OE1 1 
ATOM   873  O OE2 . GLU B 1 10  ? 28.734 -18.832 -12.397 1.00 52.94  ? 10  GLU B OE2 1 
ATOM   874  N N   . GLN B 1 11  ? 34.622 -16.540 -14.832 1.00 46.81  ? 11  GLN B N   1 
ATOM   875  C CA  . GLN B 1 11  ? 35.938 -16.813 -15.404 1.00 52.29  ? 11  GLN B CA  1 
ATOM   876  C C   . GLN B 1 11  ? 36.933 -17.185 -14.300 1.00 65.31  ? 11  GLN B C   1 
ATOM   877  O O   . GLN B 1 11  ? 37.202 -16.384 -13.399 1.00 69.22  ? 11  GLN B O   1 
ATOM   878  C CB  . GLN B 1 11  ? 36.438 -15.587 -16.174 1.00 53.68  ? 11  GLN B CB  1 
ATOM   879  C CG  . GLN B 1 11  ? 37.696 -15.833 -16.994 1.00 54.56  ? 11  GLN B CG  1 
ATOM   880  C CD  . GLN B 1 11  ? 38.099 -14.628 -17.828 1.00 60.46  ? 11  GLN B CD  1 
ATOM   881  O OE1 . GLN B 1 11  ? 37.948 -13.480 -17.397 1.00 59.04  ? 11  GLN B OE1 1 
ATOM   882  N NE2 . GLN B 1 11  ? 38.619 -14.883 -19.027 1.00 62.44  ? 11  GLN B NE2 1 
ATOM   883  N N   . LYS B 1 12  ? 37.481 -18.395 -14.381 1.00 74.79  ? 12  LYS B N   1 
ATOM   884  C CA  . LYS B 1 12  ? 38.409 -18.895 -13.362 1.00 82.79  ? 12  LYS B CA  1 
ATOM   885  C C   . LYS B 1 12  ? 39.795 -18.258 -13.472 1.00 85.24  ? 12  LYS B C   1 
ATOM   886  O O   . LYS B 1 12  ? 40.378 -17.854 -12.462 1.00 86.16  ? 12  LYS B O   1 
ATOM   887  C CB  . LYS B 1 12  ? 38.539 -20.419 -13.454 1.00 96.74  ? 12  LYS B CB  1 
ATOM   888  C CG  . LYS B 1 12  ? 39.262 -21.052 -12.271 1.00 104.82 ? 12  LYS B CG  1 
ATOM   889  C CD  . LYS B 1 12  ? 39.555 -22.526 -12.499 1.00 109.57 ? 12  LYS B CD  1 
ATOM   890  C CE  . LYS B 1 12  ? 38.292 -23.370 -12.444 1.00 113.62 ? 12  LYS B CE  1 
ATOM   891  N NZ  . LYS B 1 12  ? 38.598 -24.823 -12.539 1.00 117.45 ? 12  LYS B NZ  1 
ATOM   892  N N   . GLU B 1 13  ? 40.322 -18.186 -14.693 1.00 80.97  ? 13  GLU B N   1 
ATOM   893  C CA  . GLU B 1 13  ? 41.670 -17.666 -14.934 1.00 84.84  ? 13  GLU B CA  1 
ATOM   894  C C   . GLU B 1 13  ? 41.669 -16.605 -16.031 1.00 80.49  ? 13  GLU B C   1 
ATOM   895  O O   . GLU B 1 13  ? 40.820 -16.628 -16.923 1.00 82.27  ? 13  GLU B O   1 
ATOM   896  C CB  . GLU B 1 13  ? 42.617 -18.807 -15.306 1.00 91.95  ? 13  GLU B CB  1 
ATOM   897  C CG  . GLU B 1 13  ? 42.745 -19.874 -14.228 1.00 98.98  ? 13  GLU B CG  1 
ATOM   898  C CD  . GLU B 1 13  ? 43.590 -21.057 -14.662 1.00 104.37 ? 13  GLU B CD  1 
ATOM   899  O OE1 . GLU B 1 13  ? 44.603 -20.848 -15.364 1.00 111.55 ? 13  GLU B OE1 1 
ATOM   900  O OE2 . GLU B 1 13  ? 43.243 -22.199 -14.292 1.00 103.36 ? 13  GLU B OE2 1 
ATOM   901  N N   . SER B 1 14  ? 42.634 -15.690 -15.959 1.00 80.15  ? 14  SER B N   1 
ATOM   902  C CA  . SER B 1 14  ? 42.716 -14.536 -16.864 1.00 87.92  ? 14  SER B CA  1 
ATOM   903  C C   . SER B 1 14  ? 42.663 -14.913 -18.344 1.00 75.99  ? 14  SER B C   1 
ATOM   904  O O   . SER B 1 14  ? 41.970 -14.268 -19.130 1.00 79.25  ? 14  SER B O   1 
ATOM   905  C CB  . SER B 1 14  ? 43.999 -13.744 -16.595 1.00 93.91  ? 14  SER B CB  1 
ATOM   906  O OG  . SER B 1 14  ? 44.051 -13.292 -15.254 1.00 100.97 ? 14  SER B OG  1 
ATOM   907  N N   . ASN B 1 15  ? 43.407 -15.951 -18.716 1.00 83.39  ? 15  ASN B N   1 
ATOM   908  C CA  . ASN B 1 15  ? 43.461 -16.410 -20.108 1.00 90.59  ? 15  ASN B CA  1 
ATOM   909  C C   . ASN B 1 15  ? 42.388 -17.448 -20.453 1.00 88.17  ? 15  ASN B C   1 
ATOM   910  O O   . ASN B 1 15  ? 42.148 -17.725 -21.629 1.00 98.92  ? 15  ASN B O   1 
ATOM   911  C CB  . ASN B 1 15  ? 44.853 -16.967 -20.439 1.00 92.53  ? 15  ASN B CB  1 
ATOM   912  C CG  . ASN B 1 15  ? 45.218 -18.186 -19.607 1.00 96.41  ? 15  ASN B CG  1 
ATOM   913  O OD1 . ASN B 1 15  ? 44.660 -18.414 -18.532 1.00 99.56  ? 15  ASN B OD1 1 
ATOM   914  N ND2 . ASN B 1 15  ? 46.168 -18.972 -20.099 1.00 100.07 ? 15  ASN B ND2 1 
ATOM   915  N N   . GLY B 1 16  ? 41.748 -18.013 -19.432 1.00 78.22  ? 16  GLY B N   1 
ATOM   916  C CA  . GLY B 1 16  ? 40.762 -19.075 -19.626 1.00 71.93  ? 16  GLY B CA  1 
ATOM   917  C C   . GLY B 1 16  ? 39.410 -18.581 -20.120 1.00 70.57  ? 16  GLY B C   1 
ATOM   918  O O   . GLY B 1 16  ? 39.123 -17.379 -20.070 1.00 72.25  ? 16  GLY B O   1 
ATOM   919  N N   . PRO B 1 17  ? 38.553 -19.511 -20.585 1.00 74.55  ? 17  PRO B N   1 
ATOM   920  C CA  . PRO B 1 17  ? 37.263 -19.118 -21.140 1.00 71.04  ? 17  PRO B CA  1 
ATOM   921  C C   . PRO B 1 17  ? 36.299 -18.643 -20.058 1.00 61.29  ? 17  PRO B C   1 
ATOM   922  O O   . PRO B 1 17  ? 36.517 -18.902 -18.873 1.00 65.96  ? 17  PRO B O   1 
ATOM   923  C CB  . PRO B 1 17  ? 36.743 -20.410 -21.801 1.00 74.84  ? 17  PRO B CB  1 
ATOM   924  C CG  . PRO B 1 17  ? 37.825 -21.433 -21.644 1.00 81.75  ? 17  PRO B CG  1 
ATOM   925  C CD  . PRO B 1 17  ? 38.672 -20.975 -20.502 1.00 80.71  ? 17  PRO B CD  1 
ATOM   926  N N   . VAL B 1 18  ? 35.244 -17.952 -20.475 1.00 52.14  ? 18  VAL B N   1 
ATOM   927  C CA  . VAL B 1 18  ? 34.235 -17.449 -19.544 1.00 48.69  ? 18  VAL B CA  1 
ATOM   928  C C   . VAL B 1 18  ? 32.946 -18.239 -19.737 1.00 49.88  ? 18  VAL B C   1 
ATOM   929  O O   . VAL B 1 18  ? 32.461 -18.396 -20.858 1.00 46.74  ? 18  VAL B O   1 
ATOM   930  C CB  . VAL B 1 18  ? 34.001 -15.919 -19.676 1.00 50.99  ? 18  VAL B CB  1 
ATOM   931  C CG1 . VAL B 1 18  ? 33.982 -15.474 -21.129 1.00 61.08  ? 18  VAL B CG1 1 
ATOM   932  C CG2 . VAL B 1 18  ? 32.721 -15.482 -18.966 1.00 46.23  ? 18  VAL B CG2 1 
ATOM   933  N N   . LYS B 1 19  ? 32.417 -18.752 -18.631 1.00 48.27  ? 19  LYS B N   1 
ATOM   934  C CA  . LYS B 1 19  ? 31.156 -19.486 -18.633 1.00 47.68  ? 19  LYS B CA  1 
ATOM   935  C C   . LYS B 1 19  ? 30.004 -18.492 -18.538 1.00 45.04  ? 19  LYS B C   1 
ATOM   936  O O   . LYS B 1 19  ? 29.979 -17.659 -17.630 1.00 46.31  ? 19  LYS B O   1 
ATOM   937  C CB  . LYS B 1 19  ? 31.106 -20.454 -17.450 1.00 57.70  ? 19  LYS B CB  1 
ATOM   938  C CG  . LYS B 1 19  ? 32.224 -21.490 -17.447 1.00 64.11  ? 19  LYS B CG  1 
ATOM   939  C CD  . LYS B 1 19  ? 32.579 -21.947 -16.038 1.00 74.87  ? 19  LYS B CD  1 
ATOM   940  C CE  . LYS B 1 19  ? 33.428 -20.925 -15.289 1.00 74.71  ? 19  LYS B CE  1 
ATOM   941  N NZ  . LYS B 1 19  ? 34.805 -20.773 -15.840 1.00 74.01  ? 19  LYS B NZ  1 
ATOM   942  N N   . VAL B 1 20  ? 29.069 -18.580 -19.483 1.00 41.28  ? 20  VAL B N   1 
ATOM   943  C CA  . VAL B 1 20  ? 27.904 -17.698 -19.536 1.00 39.65  ? 20  VAL B CA  1 
ATOM   944  C C   . VAL B 1 20  ? 26.642 -18.533 -19.326 1.00 39.68  ? 20  VAL B C   1 
ATOM   945  O O   . VAL B 1 20  ? 26.366 -19.448 -20.106 1.00 44.23  ? 20  VAL B O   1 
ATOM   946  C CB  . VAL B 1 20  ? 27.806 -16.972 -20.895 1.00 41.08  ? 20  VAL B CB  1 
ATOM   947  C CG1 . VAL B 1 20  ? 26.703 -15.917 -20.866 1.00 39.46  ? 20  VAL B CG1 1 
ATOM   948  C CG2 . VAL B 1 20  ? 29.141 -16.340 -21.268 1.00 39.94  ? 20  VAL B CG2 1 
ATOM   949  N N   . TRP B 1 21  ? 25.884 -18.231 -18.275 1.00 35.03  ? 21  TRP B N   1 
ATOM   950  C CA  . TRP B 1 21  ? 24.661 -18.978 -17.989 1.00 35.20  ? 21  TRP B CA  1 
ATOM   951  C C   . TRP B 1 21  ? 23.563 -18.144 -17.337 1.00 31.40  ? 21  TRP B C   1 
ATOM   952  O O   . TRP B 1 21  ? 23.819 -17.107 -16.716 1.00 31.93  ? 21  TRP B O   1 
ATOM   953  C CB  . TRP B 1 21  ? 24.972 -20.204 -17.118 1.00 36.34  ? 21  TRP B CB  1 
ATOM   954  C CG  . TRP B 1 21  ? 25.385 -19.865 -15.717 1.00 36.35  ? 21  TRP B CG  1 
ATOM   955  C CD1 . TRP B 1 21  ? 26.634 -19.515 -15.289 1.00 37.87  ? 21  TRP B CD1 1 
ATOM   956  C CD2 . TRP B 1 21  ? 24.544 -19.851 -14.560 1.00 35.27  ? 21  TRP B CD2 1 
ATOM   957  N NE1 . TRP B 1 21  ? 26.621 -19.279 -13.936 1.00 36.33  ? 21  TRP B NE1 1 
ATOM   958  C CE2 . TRP B 1 21  ? 25.349 -19.475 -13.463 1.00 36.25  ? 21  TRP B CE2 1 
ATOM   959  C CE3 . TRP B 1 21  ? 23.186 -20.109 -14.345 1.00 34.91  ? 21  TRP B CE3 1 
ATOM   960  C CZ2 . TRP B 1 21  ? 24.841 -19.360 -12.166 1.00 38.21  ? 21  TRP B CZ2 1 
ATOM   961  C CZ3 . TRP B 1 21  ? 22.679 -19.992 -13.055 1.00 39.81  ? 21  TRP B CZ3 1 
ATOM   962  C CH2 . TRP B 1 21  ? 23.505 -19.621 -11.983 1.00 36.53  ? 21  TRP B CH2 1 
ATOM   963  N N   . GLY B 1 22  ? 22.333 -18.622 -17.493 1.00 32.56  ? 22  GLY B N   1 
ATOM   964  C CA  . GLY B 1 22  ? 21.155 -17.967 -16.951 1.00 32.45  ? 22  GLY B CA  1 
ATOM   965  C C   . GLY B 1 22  ? 19.933 -18.315 -17.777 1.00 32.37  ? 22  GLY B C   1 
ATOM   966  O O   . GLY B 1 22  ? 19.887 -19.363 -18.431 1.00 35.46  ? 22  GLY B O   1 
ATOM   967  N N   . SER B 1 23  ? 18.938 -17.438 -17.747 1.00 32.51  ? 23  SER B N   1 
ATOM   968  C CA  . SER B 1 23  ? 17.729 -17.635 -18.538 1.00 33.89  ? 23  SER B CA  1 
ATOM   969  C C   . SER B 1 23  ? 17.106 -16.306 -18.956 1.00 34.41  ? 23  SER B C   1 
ATOM   970  O O   . SER B 1 23  ? 17.281 -15.285 -18.287 1.00 35.69  ? 23  SER B O   1 
ATOM   971  C CB  . SER B 1 23  ? 16.712 -18.477 -17.764 1.00 36.06  ? 23  SER B CB  1 
ATOM   972  O OG  . SER B 1 23  ? 16.325 -17.833 -16.563 1.00 37.61  ? 23  SER B OG  1 
ATOM   973  N N   . ILE B 1 24  ? 16.396 -16.336 -20.080 1.00 34.89  ? 24  ILE B N   1 
ATOM   974  C CA  . ILE B 1 24  ? 15.680 -15.176 -20.601 1.00 33.11  ? 24  ILE B CA  1 
ATOM   975  C C   . ILE B 1 24  ? 14.241 -15.597 -20.886 1.00 33.86  ? 24  ILE B C   1 
ATOM   976  O O   . ILE B 1 24  ? 14.006 -16.656 -21.471 1.00 35.15  ? 24  ILE B O   1 
ATOM   977  C CB  . ILE B 1 24  ? 16.317 -14.636 -21.897 1.00 34.44  ? 24  ILE B CB  1 
ATOM   978  C CG1 . ILE B 1 24  ? 17.838 -14.509 -21.740 1.00 35.97  ? 24  ILE B CG1 1 
ATOM   979  C CG2 . ILE B 1 24  ? 15.695 -13.293 -22.265 1.00 35.70  ? 24  ILE B CG2 1 
ATOM   980  C CD1 . ILE B 1 24  ? 18.563 -14.072 -22.996 1.00 38.63  ? 24  ILE B CD1 1 
ATOM   981  N N   . LYS B 1 25  ? 13.288 -14.765 -20.476 1.00 35.90  ? 25  LYS B N   1 
ATOM   982  C CA  . LYS B 1 25  ? 11.865 -15.083 -20.598 1.00 39.70  ? 25  LYS B CA  1 
ATOM   983  C C   . LYS B 1 25  ? 11.119 -13.993 -21.359 1.00 38.60  ? 25  LYS B C   1 
ATOM   984  O O   . LYS B 1 25  ? 11.610 -12.873 -21.494 1.00 38.89  ? 25  LYS B O   1 
ATOM   985  C CB  . LYS B 1 25  ? 11.252 -15.273 -19.209 1.00 45.40  ? 25  LYS B CB  1 
ATOM   986  C CG  . LYS B 1 25  ? 11.949 -16.347 -18.386 1.00 51.36  ? 25  LYS B CG  1 
ATOM   987  C CD  . LYS B 1 25  ? 11.312 -16.531 -17.017 1.00 56.37  ? 25  LYS B CD  1 
ATOM   988  C CE  . LYS B 1 25  ? 11.855 -17.766 -16.311 1.00 55.22  ? 25  LYS B CE  1 
ATOM   989  N NZ  . LYS B 1 25  ? 13.342 -17.757 -16.175 1.00 57.34  ? 25  LYS B NZ  1 
ATOM   990  N N   . GLY B 1 26  ? 9.935  -14.337 -21.858 1.00 42.41  ? 26  GLY B N   1 
ATOM   991  C CA  . GLY B 1 26  ? 9.091  -13.397 -22.602 1.00 45.02  ? 26  GLY B CA  1 
ATOM   992  C C   . GLY B 1 26  ? 9.423  -13.297 -24.082 1.00 45.20  ? 26  GLY B C   1 
ATOM   993  O O   . GLY B 1 26  ? 8.956  -12.380 -24.762 1.00 44.09  ? 26  GLY B O   1 
ATOM   994  N N   . LEU B 1 27  ? 10.215 -14.244 -24.584 1.00 44.08  ? 27  LEU B N   1 
ATOM   995  C CA  . LEU B 1 27  ? 10.646 -14.250 -25.984 1.00 44.64  ? 27  LEU B CA  1 
ATOM   996  C C   . LEU B 1 27  ? 9.659  -15.003 -26.868 1.00 48.45  ? 27  LEU B C   1 
ATOM   997  O O   . LEU B 1 27  ? 8.890  -15.832 -26.382 1.00 51.39  ? 27  LEU B O   1 
ATOM   998  C CB  . LEU B 1 27  ? 12.020 -14.914 -26.112 1.00 44.27  ? 27  LEU B CB  1 
ATOM   999  C CG  . LEU B 1 27  ? 13.191 -14.217 -25.413 1.00 42.62  ? 27  LEU B CG  1 
ATOM   1000 C CD1 . LEU B 1 27  ? 14.392 -15.147 -25.319 1.00 43.18  ? 27  LEU B CD1 1 
ATOM   1001 C CD2 . LEU B 1 27  ? 13.560 -12.930 -26.138 1.00 43.43  ? 27  LEU B CD2 1 
ATOM   1002 N N   . THR B 1 28  ? 9.688  -14.716 -28.168 1.00 45.95  ? 28  THR B N   1 
ATOM   1003 C CA  . THR B 1 28  ? 8.956  -15.530 -29.142 1.00 50.99  ? 28  THR B CA  1 
ATOM   1004 C C   . THR B 1 28  ? 9.735  -16.818 -29.375 1.00 53.36  ? 28  THR B C   1 
ATOM   1005 O O   . THR B 1 28  ? 10.953 -16.853 -29.192 1.00 51.54  ? 28  THR B O   1 
ATOM   1006 C CB  . THR B 1 28  ? 8.755  -14.808 -30.491 1.00 42.80  ? 28  THR B CB  1 
ATOM   1007 O OG1 . THR B 1 28  ? 10.027 -14.462 -31.055 1.00 47.01  ? 28  THR B OG1 1 
ATOM   1008 C CG2 . THR B 1 28  ? 7.913  -13.551 -30.312 1.00 44.21  ? 28  THR B CG2 1 
ATOM   1009 N N   . GLU B 1 29  ? 9.034  -17.871 -29.776 1.00 58.52  ? 29  GLU B N   1 
ATOM   1010 C CA  . GLU B 1 29  ? 9.662  -19.173 -29.996 1.00 62.32  ? 29  GLU B CA  1 
ATOM   1011 C C   . GLU B 1 29  ? 10.681 -19.099 -31.132 1.00 63.46  ? 29  GLU B C   1 
ATOM   1012 O O   . GLU B 1 29  ? 10.462 -18.403 -32.126 1.00 64.38  ? 29  GLU B O   1 
ATOM   1013 C CB  . GLU B 1 29  ? 8.603  -20.237 -30.306 1.00 66.79  ? 29  GLU B CB  1 
ATOM   1014 C CG  . GLU B 1 29  ? 9.135  -21.663 -30.290 1.00 67.91  ? 29  GLU B CG  1 
ATOM   1015 C CD  . GLU B 1 29  ? 8.079  -22.701 -30.626 1.00 72.43  ? 29  GLU B CD  1 
ATOM   1016 O OE1 . GLU B 1 29  ? 6.905  -22.329 -30.843 1.00 72.84  ? 29  GLU B OE1 1 
ATOM   1017 O OE2 . GLU B 1 29  ? 8.430  -23.898 -30.674 1.00 75.96  ? 29  GLU B OE2 1 
ATOM   1018 N N   . GLY B 1 30  ? 11.795 -19.810 -30.968 1.00 60.65  ? 30  GLY B N   1 
ATOM   1019 C CA  . GLY B 1 30  ? 12.842 -19.875 -31.988 1.00 63.40  ? 30  GLY B CA  1 
ATOM   1020 C C   . GLY B 1 30  ? 14.158 -19.261 -31.547 1.00 64.67  ? 30  GLY B C   1 
ATOM   1021 O O   . GLY B 1 30  ? 14.350 -18.945 -30.371 1.00 58.31  ? 30  GLY B O   1 
ATOM   1022 N N   . LEU B 1 31  ? 15.061 -19.088 -32.509 1.00 68.79  ? 31  LEU B N   1 
ATOM   1023 C CA  . LEU B 1 31  ? 16.405 -18.572 -32.246 1.00 68.11  ? 31  LEU B CA  1 
ATOM   1024 C C   . LEU B 1 31  ? 16.395 -17.055 -32.069 1.00 65.77  ? 31  LEU B C   1 
ATOM   1025 O O   . LEU B 1 31  ? 15.589 -16.359 -32.684 1.00 64.99  ? 31  LEU B O   1 
ATOM   1026 C CB  . LEU B 1 31  ? 17.352 -18.947 -33.390 1.00 75.03  ? 31  LEU B CB  1 
ATOM   1027 C CG  . LEU B 1 31  ? 17.507 -20.443 -33.677 1.00 81.92  ? 31  LEU B CG  1 
ATOM   1028 C CD1 . LEU B 1 31  ? 18.196 -20.663 -35.015 1.00 86.08  ? 31  LEU B CD1 1 
ATOM   1029 C CD2 . LEU B 1 31  ? 18.271 -21.135 -32.558 1.00 85.12  ? 31  LEU B CD2 1 
ATOM   1030 N N   . HIS B 1 32  ? 17.297 -16.553 -31.229 1.00 59.96  ? 32  HIS B N   1 
ATOM   1031 C CA  . HIS B 1 32  ? 17.421 -15.114 -30.975 1.00 56.59  ? 32  HIS B CA  1 
ATOM   1032 C C   . HIS B 1 32  ? 18.886 -14.706 -30.885 1.00 53.02  ? 32  HIS B C   1 
ATOM   1033 O O   . HIS B 1 32  ? 19.656 -15.319 -30.146 1.00 48.31  ? 32  HIS B O   1 
ATOM   1034 C CB  . HIS B 1 32  ? 16.714 -14.736 -29.672 1.00 55.85  ? 32  HIS B CB  1 
ATOM   1035 C CG  . HIS B 1 32  ? 15.225 -14.863 -29.735 1.00 53.84  ? 32  HIS B CG  1 
ATOM   1036 N ND1 . HIS B 1 32  ? 14.413 -13.864 -30.228 1.00 52.61  ? 32  HIS B ND1 1 
ATOM   1037 C CD2 . HIS B 1 32  ? 14.401 -15.872 -29.369 1.00 54.71  ? 32  HIS B CD2 1 
ATOM   1038 C CE1 . HIS B 1 32  ? 13.153 -14.253 -30.161 1.00 54.12  ? 32  HIS B CE1 1 
ATOM   1039 N NE2 . HIS B 1 32  ? 13.118 -15.468 -29.644 1.00 54.48  ? 32  HIS B NE2 1 
ATOM   1040 N N   . GLY B 1 33  ? 19.260 -13.668 -31.633 1.00 50.22  ? 33  GLY B N   1 
ATOM   1041 C CA  . GLY B 1 33  ? 20.623 -13.136 -31.607 1.00 46.91  ? 33  GLY B CA  1 
ATOM   1042 C C   . GLY B 1 33  ? 21.046 -12.719 -30.209 1.00 40.14  ? 33  GLY B C   1 
ATOM   1043 O O   . GLY B 1 33  ? 20.301 -12.035 -29.512 1.00 42.02  ? 33  GLY B O   1 
ATOM   1044 N N   . PHE B 1 34  ? 22.245 -13.135 -29.812 1.00 30.14  ? 34  PHE B N   1 
ATOM   1045 C CA  . PHE B 1 34  ? 22.739 -12.959 -28.445 1.00 40.19  ? 34  PHE B CA  1 
ATOM   1046 C C   . PHE B 1 34  ? 24.215 -12.557 -28.492 1.00 43.74  ? 34  PHE B C   1 
ATOM   1047 O O   . PHE B 1 34  ? 25.042 -13.312 -29.003 1.00 47.33  ? 34  PHE B O   1 
ATOM   1048 C CB  . PHE B 1 34  ? 22.566 -14.277 -27.681 1.00 40.65  ? 34  PHE B CB  1 
ATOM   1049 C CG  . PHE B 1 34  ? 22.844 -14.182 -26.204 1.00 33.94  ? 34  PHE B CG  1 
ATOM   1050 C CD1 . PHE B 1 34  ? 22.106 -13.334 -25.397 1.00 29.97  ? 34  PHE B CD1 1 
ATOM   1051 C CD2 . PHE B 1 34  ? 23.815 -14.982 -25.613 1.00 29.30  ? 34  PHE B CD2 1 
ATOM   1052 C CE1 . PHE B 1 34  ? 22.348 -13.258 -24.034 1.00 22.36  ? 34  PHE B CE1 1 
ATOM   1053 C CE2 . PHE B 1 34  ? 24.062 -14.911 -24.251 1.00 32.65  ? 34  PHE B CE2 1 
ATOM   1054 C CZ  . PHE B 1 34  ? 23.328 -14.049 -23.462 1.00 25.81  ? 34  PHE B CZ  1 
ATOM   1055 N N   . HIS B 1 35  ? 24.541 -11.370 -27.977 1.00 46.22  ? 35  HIS B N   1 
ATOM   1056 C CA  . HIS B 1 35  ? 25.925 -10.866 -28.030 1.00 47.28  ? 35  HIS B CA  1 
ATOM   1057 C C   . HIS B 1 35  ? 26.167 -9.608  -27.202 1.00 41.97  ? 35  HIS B C   1 
ATOM   1058 O O   . HIS B 1 35  ? 25.236 -8.889  -26.837 1.00 41.15  ? 35  HIS B O   1 
ATOM   1059 C CB  . HIS B 1 35  ? 26.347 -10.594 -29.481 1.00 56.20  ? 35  HIS B CB  1 
ATOM   1060 C CG  . HIS B 1 35  ? 25.238 -10.092 -30.344 1.00 57.48  ? 35  HIS B CG  1 
ATOM   1061 N ND1 . HIS B 1 35  ? 24.602 -8.895  -30.109 1.00 58.61  ? 35  HIS B ND1 1 
ATOM   1062 C CD2 . HIS B 1 35  ? 24.637 -10.634 -31.430 1.00 63.87  ? 35  HIS B CD2 1 
ATOM   1063 C CE1 . HIS B 1 35  ? 23.657 -8.721  -31.013 1.00 67.07  ? 35  HIS B CE1 1 
ATOM   1064 N NE2 . HIS B 1 35  ? 23.661 -9.757  -31.831 1.00 65.70  ? 35  HIS B NE2 1 
ATOM   1065 N N   . VAL B 1 36  ? 27.441 -9.354  -26.923 1.00 36.99  ? 36  VAL B N   1 
ATOM   1066 C CA  . VAL B 1 36  ? 27.861 -8.145  -26.225 1.00 37.56  ? 36  VAL B CA  1 
ATOM   1067 C C   . VAL B 1 36  ? 28.050 -7.049  -27.270 1.00 39.53  ? 36  VAL B C   1 
ATOM   1068 O O   . VAL B 1 36  ? 28.635 -7.293  -28.328 1.00 41.25  ? 36  VAL B O   1 
ATOM   1069 C CB  . VAL B 1 36  ? 29.176 -8.361  -25.446 1.00 39.61  ? 36  VAL B CB  1 
ATOM   1070 C CG1 . VAL B 1 36  ? 29.512 -7.138  -24.603 1.00 38.99  ? 36  VAL B CG1 1 
ATOM   1071 C CG2 . VAL B 1 36  ? 29.081 -9.595  -24.557 1.00 40.68  ? 36  VAL B CG2 1 
ATOM   1072 N N   . HIS B 1 37  ? 27.550 -5.849  -26.977 1.00 38.92  ? 37  HIS B N   1 
ATOM   1073 C CA  . HIS B 1 37  ? 27.651 -4.737  -27.919 1.00 39.68  ? 37  HIS B CA  1 
ATOM   1074 C C   . HIS B 1 37  ? 29.095 -4.261  -28.049 1.00 43.93  ? 37  HIS B C   1 
ATOM   1075 O O   . HIS B 1 37  ? 29.786 -4.067  -27.048 1.00 44.88  ? 37  HIS B O   1 
ATOM   1076 C CB  . HIS B 1 37  ? 26.762 -3.566  -27.495 1.00 40.00  ? 37  HIS B CB  1 
ATOM   1077 C CG  . HIS B 1 37  ? 26.934 -2.349  -28.348 1.00 40.70  ? 37  HIS B CG  1 
ATOM   1078 N ND1 . HIS B 1 37  ? 26.394 -2.245  -29.612 1.00 41.77  ? 37  HIS B ND1 1 
ATOM   1079 C CD2 . HIS B 1 37  ? 27.605 -1.194  -28.130 1.00 42.55  ? 37  HIS B CD2 1 
ATOM   1080 C CE1 . HIS B 1 37  ? 26.715 -1.073  -30.130 1.00 43.19  ? 37  HIS B CE1 1 
ATOM   1081 N NE2 . HIS B 1 37  ? 27.450 -0.417  -29.252 1.00 44.86  ? 37  HIS B NE2 1 
ATOM   1082 N N   . GLY B 1 38  ? 29.535 -4.068  -29.289 1.00 46.63  ? 38  GLY B N   1 
ATOM   1083 C CA  . GLY B 1 38  ? 30.898 -3.621  -29.572 1.00 53.26  ? 38  GLY B CA  1 
ATOM   1084 C C   . GLY B 1 38  ? 31.590 -4.544  -30.554 1.00 60.75  ? 38  GLY B C   1 
ATOM   1085 O O   . GLY B 1 38  ? 30.939 -5.333  -31.244 1.00 59.76  ? 38  GLY B O   1 
ATOM   1086 N N   . ALA B 1 39  ? 32.917 -4.446  -30.607 1.00 65.66  ? 39  ALA B N   1 
ATOM   1087 C CA  . ALA B 1 39  ? 33.719 -5.243  -31.533 1.00 65.21  ? 39  ALA B CA  1 
ATOM   1088 C C   . ALA B 1 39  ? 33.512 -6.735  -31.282 1.00 66.71  ? 39  ALA B C   1 
ATOM   1089 O O   . ALA B 1 39  ? 33.946 -7.270  -30.259 1.00 68.15  ? 39  ALA B O   1 
ATOM   1090 C CB  . ALA B 1 39  ? 35.193 -4.880  -31.409 1.00 65.92  ? 39  ALA B CB  1 
ATOM   1091 N N   . GLY B 1 40  ? 32.831 -7.393  -32.216 1.00 64.24  ? 40  GLY B N   1 
ATOM   1092 C CA  . GLY B 1 40  ? 32.558 -8.823  -32.122 1.00 76.68  ? 40  GLY B CA  1 
ATOM   1093 C C   . GLY B 1 40  ? 31.664 -9.167  -30.945 1.00 81.99  ? 40  GLY B C   1 
ATOM   1094 O O   . GLY B 1 40  ? 30.516 -8.723  -30.876 1.00 80.91  ? 40  GLY B O   1 
ATOM   1095 N N   . GLY B 1 41  ? 32.198 -9.960  -30.017 1.00 82.99  ? 41  GLY B N   1 
ATOM   1096 C CA  . GLY B 1 41  ? 31.449 -10.402 -28.842 1.00 80.90  ? 41  GLY B CA  1 
ATOM   1097 C C   . GLY B 1 41  ? 30.211 -11.211 -29.189 1.00 77.57  ? 41  GLY B C   1 
ATOM   1098 O O   . GLY B 1 41  ? 29.227 -11.189 -28.450 1.00 66.56  ? 41  GLY B O   1 
ATOM   1099 N N   . ASP B 1 42  ? 30.264 -11.929 -30.311 1.00 78.08  ? 42  ASP B N   1 
ATOM   1100 C CA  . ASP B 1 42  ? 29.120 -12.700 -30.790 1.00 76.00  ? 42  ASP B CA  1 
ATOM   1101 C C   . ASP B 1 42  ? 29.009 -14.013 -30.023 1.00 73.93  ? 42  ASP B C   1 
ATOM   1102 O O   . ASP B 1 42  ? 29.874 -14.881 -30.140 1.00 75.70  ? 42  ASP B O   1 
ATOM   1103 C CB  . ASP B 1 42  ? 29.235 -12.972 -32.295 1.00 82.75  ? 42  ASP B CB  1 
ATOM   1104 C CG  . ASP B 1 42  ? 27.976 -13.605 -32.880 1.00 82.83  ? 42  ASP B CG  1 
ATOM   1105 O OD1 . ASP B 1 42  ? 26.880 -13.431 -32.304 1.00 82.57  ? 42  ASP B OD1 1 
ATOM   1106 O OD2 . ASP B 1 42  ? 28.085 -14.274 -33.928 1.00 84.64  ? 42  ASP B OD2 1 
ATOM   1107 N N   . LEU B 1 43  ? 27.939 -14.147 -29.241 1.00 68.50  ? 43  LEU B N   1 
ATOM   1108 C CA  . LEU B 1 43  ? 27.686 -15.359 -28.460 1.00 64.12  ? 43  LEU B CA  1 
ATOM   1109 C C   . LEU B 1 43  ? 26.661 -16.267 -29.146 1.00 59.08  ? 43  LEU B C   1 
ATOM   1110 O O   . LEU B 1 43  ? 25.979 -17.049 -28.487 1.00 64.71  ? 43  LEU B O   1 
ATOM   1111 C CB  . LEU B 1 43  ? 27.206 -14.988 -27.052 1.00 61.85  ? 43  LEU B CB  1 
ATOM   1112 C CG  . LEU B 1 43  ? 28.060 -13.975 -26.285 1.00 60.90  ? 43  LEU B CG  1 
ATOM   1113 C CD1 . LEU B 1 43  ? 27.377 -13.585 -24.982 1.00 57.18  ? 43  LEU B CD1 1 
ATOM   1114 C CD2 . LEU B 1 43  ? 29.454 -14.523 -26.020 1.00 62.35  ? 43  LEU B CD2 1 
ATOM   1115 N N   . GLY B 1 44  ? 26.559 -16.158 -30.469 1.00 60.22  ? 44  GLY B N   1 
ATOM   1116 C CA  . GLY B 1 44  ? 25.657 -16.990 -31.256 1.00 65.65  ? 44  GLY B CA  1 
ATOM   1117 C C   . GLY B 1 44  ? 24.199 -16.640 -31.035 1.00 65.91  ? 44  GLY B C   1 
ATOM   1118 O O   . GLY B 1 44  ? 23.853 -15.474 -30.834 1.00 64.86  ? 44  GLY B O   1 
ATOM   1119 N N   . ASN B 1 45  ? 23.348 -17.659 -31.084 1.00 68.37  ? 45  ASN B N   1 
ATOM   1120 C CA  . ASN B 1 45  ? 21.925 -17.503 -30.821 1.00 70.33  ? 45  ASN B CA  1 
ATOM   1121 C C   . ASN B 1 45  ? 21.515 -18.330 -29.610 1.00 62.55  ? 45  ASN B C   1 
ATOM   1122 O O   . ASN B 1 45  ? 22.114 -19.369 -29.331 1.00 61.65  ? 45  ASN B O   1 
ATOM   1123 C CB  . ASN B 1 45  ? 21.103 -17.942 -32.036 1.00 77.37  ? 45  ASN B CB  1 
ATOM   1124 C CG  . ASN B 1 45  ? 21.459 -17.175 -33.298 1.00 74.66  ? 45  ASN B CG  1 
ATOM   1125 O OD1 . ASN B 1 45  ? 21.919 -16.036 -33.241 1.00 68.86  ? 45  ASN B OD1 1 
ATOM   1126 N ND2 . ASN B 1 45  ? 21.240 -17.800 -34.450 1.00 79.81  ? 45  ASN B ND2 1 
ATOM   1127 N N   . VAL B 1 46  ? 20.507 -17.852 -28.885 1.00 60.18  ? 46  VAL B N   1 
ATOM   1128 C CA  . VAL B 1 46  ? 19.859 -18.643 -27.838 1.00 56.53  ? 46  VAL B CA  1 
ATOM   1129 C C   . VAL B 1 46  ? 18.507 -19.104 -28.367 1.00 57.08  ? 46  VAL B C   1 
ATOM   1130 O O   . VAL B 1 46  ? 17.913 -18.439 -29.218 1.00 55.41  ? 46  VAL B O   1 
ATOM   1131 C CB  . VAL B 1 46  ? 19.688 -17.860 -26.511 1.00 54.39  ? 46  VAL B CB  1 
ATOM   1132 C CG1 . VAL B 1 46  ? 21.036 -17.349 -26.018 1.00 52.86  ? 46  VAL B CG1 1 
ATOM   1133 C CG2 . VAL B 1 46  ? 18.692 -16.711 -26.652 1.00 52.21  ? 46  VAL B CG2 1 
ATOM   1134 N N   . THR B 1 47  ? 18.031 -20.241 -27.864 1.00 56.45  ? 47  THR B N   1 
ATOM   1135 C CA  . THR B 1 47  ? 16.770 -20.827 -28.315 1.00 57.08  ? 47  THR B CA  1 
ATOM   1136 C C   . THR B 1 47  ? 15.683 -20.662 -27.257 1.00 55.57  ? 47  THR B C   1 
ATOM   1137 O O   . THR B 1 47  ? 15.847 -21.102 -26.119 1.00 50.59  ? 47  THR B O   1 
ATOM   1138 C CB  . THR B 1 47  ? 16.933 -22.328 -28.628 1.00 60.08  ? 47  THR B CB  1 
ATOM   1139 O OG1 . THR B 1 47  ? 18.031 -22.516 -29.528 1.00 67.28  ? 47  THR B OG1 1 
ATOM   1140 C CG2 . THR B 1 47  ? 15.662 -22.898 -29.258 1.00 68.03  ? 47  THR B CG2 1 
ATOM   1141 N N   . ALA B 1 48  ? 14.578 -20.026 -27.645 1.00 51.98  ? 48  ALA B N   1 
ATOM   1142 C CA  . ALA B 1 48  ? 13.396 -19.917 -26.793 1.00 48.25  ? 48  ALA B CA  1 
ATOM   1143 C C   . ALA B 1 48  ? 12.421 -21.048 -27.117 1.00 55.85  ? 48  ALA B C   1 
ATOM   1144 O O   . ALA B 1 48  ? 12.149 -21.323 -28.289 1.00 59.93  ? 48  ALA B O   1 
ATOM   1145 C CB  . ALA B 1 48  ? 12.723 -18.570 -26.991 1.00 49.59  ? 48  ALA B CB  1 
ATOM   1146 N N   . ASP B 1 49  ? 11.896 -21.693 -26.077 1.00 56.38  ? 49  ASP B N   1 
ATOM   1147 C CA  . ASP B 1 49  ? 10.932 -22.784 -26.241 1.00 59.96  ? 49  ASP B CA  1 
ATOM   1148 C C   . ASP B 1 49  ? 9.520  -22.229 -26.484 1.00 59.33  ? 49  ASP B C   1 
ATOM   1149 O O   . ASP B 1 49  ? 9.349  -21.018 -26.660 1.00 55.92  ? 49  ASP B O   1 
ATOM   1150 C CB  . ASP B 1 49  ? 10.970 -23.727 -25.022 1.00 66.52  ? 49  ASP B CB  1 
ATOM   1151 C CG  . ASP B 1 49  ? 10.522 -23.055 -23.726 1.00 61.61  ? 49  ASP B CG  1 
ATOM   1152 O OD1 . ASP B 1 49  ? 10.236 -21.838 -23.725 1.00 66.60  ? 49  ASP B OD1 1 
ATOM   1153 O OD2 . ASP B 1 49  ? 10.461 -23.756 -22.696 1.00 66.79  ? 49  ASP B OD2 1 
ATOM   1154 N N   . LYS B 1 50  ? 8.521  -23.114 -26.497 1.00 58.23  ? 50  LYS B N   1 
ATOM   1155 C CA  . LYS B 1 50  ? 7.114  -22.721 -26.668 1.00 63.31  ? 50  LYS B CA  1 
ATOM   1156 C C   . LYS B 1 50  ? 6.667  -21.715 -25.607 1.00 59.59  ? 50  LYS B C   1 
ATOM   1157 O O   . LYS B 1 50  ? 5.867  -20.821 -25.885 1.00 68.05  ? 50  LYS B O   1 
ATOM   1158 C CB  . LYS B 1 50  ? 6.178  -23.937 -26.598 1.00 67.36  ? 50  LYS B CB  1 
ATOM   1159 C CG  . LYS B 1 50  ? 6.524  -25.102 -27.520 1.00 76.63  ? 50  LYS B CG  1 
ATOM   1160 C CD  . LYS B 1 50  ? 7.201  -26.272 -26.806 1.00 84.70  ? 50  LYS B CD  1 
ATOM   1161 C CE  . LYS B 1 50  ? 6.411  -26.810 -25.615 1.00 87.76  ? 50  LYS B CE  1 
ATOM   1162 N NZ  . LYS B 1 50  ? 4.955  -26.994 -25.878 1.00 90.53  ? 50  LYS B NZ  1 
ATOM   1163 N N   . ASP B 1 51  ? 7.180  -21.881 -24.393 1.00 55.31  ? 51  ASP B N   1 
ATOM   1164 C CA  . ASP B 1 51  ? 6.863  -20.987 -23.281 1.00 55.35  ? 51  ASP B CA  1 
ATOM   1165 C C   . ASP B 1 51  ? 7.549  -19.624 -23.388 1.00 51.36  ? 51  ASP B C   1 
ATOM   1166 O O   . ASP B 1 51  ? 7.215  -18.711 -22.641 1.00 51.88  ? 51  ASP B O   1 
ATOM   1167 C CB  . ASP B 1 51  ? 7.240  -21.645 -21.955 1.00 60.75  ? 51  ASP B CB  1 
ATOM   1168 C CG  . ASP B 1 51  ? 6.659  -23.030 -21.814 1.00 64.60  ? 51  ASP B CG  1 
ATOM   1169 O OD1 . ASP B 1 51  ? 5.803  -23.387 -22.651 1.00 72.18  ? 51  ASP B OD1 1 
ATOM   1170 O OD2 . ASP B 1 51  ? 7.063  -23.764 -20.888 1.00 65.35  ? 51  ASP B OD2 1 
ATOM   1171 N N   . GLY B 1 52  ? 8.499  -19.490 -24.310 1.00 46.77  ? 52  GLY B N   1 
ATOM   1172 C CA  . GLY B 1 52  ? 9.226  -18.237 -24.510 1.00 44.16  ? 52  GLY B CA  1 
ATOM   1173 C C   . GLY B 1 52  ? 10.423 -18.103 -23.587 1.00 44.27  ? 52  GLY B C   1 
ATOM   1174 O O   . GLY B 1 52  ? 10.958 -17.004 -23.408 1.00 43.67  ? 52  GLY B O   1 
ATOM   1175 N N   . VAL B 1 53  ? 10.847 -19.225 -23.010 1.00 46.78  ? 53  VAL B N   1 
ATOM   1176 C CA  . VAL B 1 53  ? 11.961 -19.258 -22.070 1.00 44.38  ? 53  VAL B CA  1 
ATOM   1177 C C   . VAL B 1 53  ? 13.193 -19.844 -22.750 1.00 43.05  ? 53  VAL B C   1 
ATOM   1178 O O   . VAL B 1 53  ? 13.127 -20.915 -23.351 1.00 42.87  ? 53  VAL B O   1 
ATOM   1179 C CB  . VAL B 1 53  ? 11.621 -20.100 -20.823 1.00 45.01  ? 53  VAL B CB  1 
ATOM   1180 C CG1 . VAL B 1 53  ? 12.780 -20.095 -19.833 1.00 46.10  ? 53  VAL B CG1 1 
ATOM   1181 C CG2 . VAL B 1 53  ? 10.356 -19.573 -20.159 1.00 42.41  ? 53  VAL B CG2 1 
ATOM   1182 N N   . ALA B 1 54  ? 14.314 -19.133 -22.648 1.00 42.98  ? 54  ALA B N   1 
ATOM   1183 C CA  . ALA B 1 54  ? 15.584 -19.597 -23.194 1.00 42.69  ? 54  ALA B CA  1 
ATOM   1184 C C   . ALA B 1 54  ? 16.562 -19.874 -22.062 1.00 41.53  ? 54  ALA B C   1 
ATOM   1185 O O   . ALA B 1 54  ? 16.852 -18.984 -21.262 1.00 44.16  ? 54  ALA B O   1 
ATOM   1186 C CB  . ALA B 1 54  ? 16.159 -18.560 -24.144 1.00 39.40  ? 54  ALA B CB  1 
ATOM   1187 N N   . ASP B 1 55  ? 17.054 -21.110 -21.993 1.00 41.58  ? 55  ASP B N   1 
ATOM   1188 C CA  . ASP B 1 55  ? 18.092 -21.486 -21.035 1.00 42.29  ? 55  ASP B CA  1 
ATOM   1189 C C   . ASP B 1 55  ? 19.460 -21.298 -21.676 1.00 45.42  ? 55  ASP B C   1 
ATOM   1190 O O   . ASP B 1 55  ? 19.775 -21.933 -22.684 1.00 50.70  ? 55  ASP B O   1 
ATOM   1191 C CB  . ASP B 1 55  ? 17.927 -22.940 -20.585 1.00 44.12  ? 55  ASP B CB  1 
ATOM   1192 C CG  . ASP B 1 55  ? 16.730 -23.138 -19.674 1.00 47.56  ? 55  ASP B CG  1 
ATOM   1193 O OD1 . ASP B 1 55  ? 16.440 -22.241 -18.855 1.00 50.78  ? 55  ASP B OD1 1 
ATOM   1194 O OD2 . ASP B 1 55  ? 16.077 -24.199 -19.772 1.00 50.94  ? 55  ASP B OD2 1 
ATOM   1195 N N   . VAL B 1 56  ? 20.269 -20.429 -21.078 1.00 39.85  ? 56  VAL B N   1 
ATOM   1196 C CA  . VAL B 1 56  ? 21.579 -20.085 -21.615 1.00 39.40  ? 56  VAL B CA  1 
ATOM   1197 C C   . VAL B 1 56  ? 22.655 -20.854 -20.861 1.00 42.87  ? 56  VAL B C   1 
ATOM   1198 O O   . VAL B 1 56  ? 22.635 -20.918 -19.633 1.00 42.92  ? 56  VAL B O   1 
ATOM   1199 C CB  . VAL B 1 56  ? 21.857 -18.569 -21.486 1.00 38.24  ? 56  VAL B CB  1 
ATOM   1200 C CG1 . VAL B 1 56  ? 23.133 -18.193 -22.226 1.00 41.32  ? 56  VAL B CG1 1 
ATOM   1201 C CG2 . VAL B 1 56  ? 20.681 -17.759 -22.012 1.00 44.65  ? 56  VAL B CG2 1 
ATOM   1202 N N   . SER B 1 57  ? 23.587 -21.442 -21.604 1.00 46.96  ? 57  SER B N   1 
ATOM   1203 C CA  . SER B 1 57  ? 24.733 -22.134 -21.015 1.00 54.96  ? 57  SER B CA  1 
ATOM   1204 C C   . SER B 1 57  ? 25.864 -22.211 -22.041 1.00 60.50  ? 57  SER B C   1 
ATOM   1205 O O   . SER B 1 57  ? 26.140 -23.271 -22.612 1.00 71.51  ? 57  SER B O   1 
ATOM   1206 C CB  . SER B 1 57  ? 24.335 -23.528 -20.525 1.00 58.47  ? 57  SER B CB  1 
ATOM   1207 O OG  . SER B 1 57  ? 25.372 -24.106 -19.752 1.00 60.66  ? 57  SER B OG  1 
ATOM   1208 N N   . ILE B 1 58  ? 26.508 -21.067 -22.259 1.00 67.32  ? 58  ILE B N   1 
ATOM   1209 C CA  . ILE B 1 58  ? 27.532 -20.907 -23.290 1.00 70.85  ? 58  ILE B CA  1 
ATOM   1210 C C   . ILE B 1 58  ? 28.915 -20.770 -22.656 1.00 71.32  ? 58  ILE B C   1 
ATOM   1211 O O   . ILE B 1 58  ? 29.052 -20.249 -21.550 1.00 74.77  ? 58  ILE B O   1 
ATOM   1212 C CB  . ILE B 1 58  ? 27.255 -19.650 -24.154 1.00 73.62  ? 58  ILE B CB  1 
ATOM   1213 C CG1 . ILE B 1 58  ? 25.844 -19.709 -24.757 1.00 63.67  ? 58  ILE B CG1 1 
ATOM   1214 C CG2 . ILE B 1 58  ? 28.297 -19.500 -25.259 1.00 73.23  ? 58  ILE B CG2 1 
ATOM   1215 C CD1 . ILE B 1 58  ? 25.381 -18.409 -25.382 1.00 61.45  ? 58  ILE B CD1 1 
ATOM   1216 N N   . GLU B 1 59  ? 29.932 -21.251 -23.364 1.00 69.14  ? 59  GLU B N   1 
ATOM   1217 C CA  . GLU B 1 59  ? 31.326 -20.995 -23.009 1.00 74.00  ? 59  GLU B CA  1 
ATOM   1218 C C   . GLU B 1 59  ? 32.004 -20.297 -24.187 1.00 71.41  ? 59  GLU B C   1 
ATOM   1219 O O   . GLU B 1 59  ? 31.830 -20.703 -25.337 1.00 71.47  ? 59  GLU B O   1 
ATOM   1220 C CB  . GLU B 1 59  ? 32.045 -22.299 -22.663 1.00 83.43  ? 59  GLU B CB  1 
ATOM   1221 C CG  . GLU B 1 59  ? 33.413 -22.096 -22.028 1.00 90.96  ? 59  GLU B CG  1 
ATOM   1222 C CD  . GLU B 1 59  ? 33.985 -23.371 -21.436 1.00 98.76  ? 59  GLU B CD  1 
ATOM   1223 O OE1 . GLU B 1 59  ? 33.264 -24.061 -20.682 1.00 99.14  ? 59  GLU B OE1 1 
ATOM   1224 O OE2 . GLU B 1 59  ? 35.163 -23.681 -21.715 1.00 99.30  ? 59  GLU B OE2 1 
ATOM   1225 N N   . ASP B 1 60  ? 32.767 -19.246 -23.900 1.00 66.00  ? 60  ASP B N   1 
ATOM   1226 C CA  . ASP B 1 60  ? 33.369 -18.425 -24.950 1.00 68.81  ? 60  ASP B CA  1 
ATOM   1227 C C   . ASP B 1 60  ? 34.796 -18.032 -24.583 1.00 73.12  ? 60  ASP B C   1 
ATOM   1228 O O   . ASP B 1 60  ? 35.061 -17.599 -23.459 1.00 71.16  ? 60  ASP B O   1 
ATOM   1229 C CB  . ASP B 1 60  ? 32.517 -17.175 -25.190 1.00 69.97  ? 60  ASP B CB  1 
ATOM   1230 C CG  . ASP B 1 60  ? 32.824 -16.502 -26.516 1.00 71.92  ? 60  ASP B CG  1 
ATOM   1231 O OD1 . ASP B 1 60  ? 33.887 -15.857 -26.631 1.00 69.22  ? 60  ASP B OD1 1 
ATOM   1232 O OD2 . ASP B 1 60  ? 31.991 -16.606 -27.441 1.00 71.85  ? 60  ASP B OD2 1 
ATOM   1233 N N   . SER B 1 61  ? 35.701 -18.175 -25.548 1.00 73.43  ? 61  SER B N   1 
ATOM   1234 C CA  . SER B 1 61  ? 37.129 -17.935 -25.337 1.00 73.61  ? 61  SER B CA  1 
ATOM   1235 C C   . SER B 1 61  ? 37.576 -16.540 -25.775 1.00 77.17  ? 61  SER B C   1 
ATOM   1236 O O   . SER B 1 61  ? 38.620 -16.061 -25.330 1.00 81.49  ? 61  SER B O   1 
ATOM   1237 C CB  . SER B 1 61  ? 37.947 -18.988 -26.088 1.00 76.82  ? 61  SER B CB  1 
ATOM   1238 O OG  . SER B 1 61  ? 37.558 -20.296 -25.708 1.00 81.38  ? 61  SER B OG  1 
ATOM   1239 N N   . VAL B 1 62  ? 36.795 -15.896 -26.642 1.00 81.78  ? 62  VAL B N   1 
ATOM   1240 C CA  . VAL B 1 62  ? 37.130 -14.563 -27.156 1.00 83.06  ? 62  VAL B CA  1 
ATOM   1241 C C   . VAL B 1 62  ? 36.920 -13.499 -26.080 1.00 71.68  ? 62  VAL B C   1 
ATOM   1242 O O   . VAL B 1 62  ? 37.826 -12.719 -25.784 1.00 69.19  ? 62  VAL B O   1 
ATOM   1243 C CB  . VAL B 1 62  ? 36.289 -14.204 -28.405 1.00 92.11  ? 62  VAL B CB  1 
ATOM   1244 C CG1 . VAL B 1 62  ? 36.592 -12.788 -28.881 1.00 88.93  ? 62  VAL B CG1 1 
ATOM   1245 C CG2 . VAL B 1 62  ? 36.542 -15.203 -29.526 1.00 94.56  ? 62  VAL B CG2 1 
ATOM   1246 N N   . ILE B 1 63  ? 35.722 -13.470 -25.503 1.00 62.42  ? 63  ILE B N   1 
ATOM   1247 C CA  . ILE B 1 63  ? 35.403 -12.506 -24.443 1.00 58.08  ? 63  ILE B CA  1 
ATOM   1248 C C   . ILE B 1 63  ? 36.155 -12.829 -23.148 1.00 49.31  ? 63  ILE B C   1 
ATOM   1249 O O   . ILE B 1 63  ? 36.620 -13.953 -22.952 1.00 48.44  ? 63  ILE B O   1 
ATOM   1250 C CB  . ILE B 1 63  ? 33.881 -12.409 -24.162 1.00 50.60  ? 63  ILE B CB  1 
ATOM   1251 C CG1 . ILE B 1 63  ? 33.257 -13.789 -23.926 1.00 46.32  ? 63  ILE B CG1 1 
ATOM   1252 C CG2 . ILE B 1 63  ? 33.173 -11.716 -25.318 1.00 59.75  ? 63  ILE B CG2 1 
ATOM   1253 C CD1 . ILE B 1 63  ? 31.957 -13.748 -23.148 1.00 47.69  ? 63  ILE B CD1 1 
ATOM   1254 N N   . SER B 1 64  ? 36.279 -11.826 -22.283 1.00 50.37  ? 64  SER B N   1 
ATOM   1255 C CA  . SER B 1 64  ? 36.945 -11.974 -20.988 1.00 52.01  ? 64  SER B CA  1 
ATOM   1256 C C   . SER B 1 64  ? 36.330 -11.021 -19.963 1.00 47.08  ? 64  SER B C   1 
ATOM   1257 O O   . SER B 1 64  ? 35.618 -10.079 -20.326 1.00 44.68  ? 64  SER B O   1 
ATOM   1258 C CB  . SER B 1 64  ? 38.445 -11.700 -21.129 1.00 50.81  ? 64  SER B CB  1 
ATOM   1259 O OG  . SER B 1 64  ? 39.103 -11.754 -19.875 1.00 48.84  ? 64  SER B OG  1 
ATOM   1260 N N   . LEU B 1 65  ? 36.597 -11.280 -18.684 1.00 45.05  ? 65  LEU B N   1 
ATOM   1261 C CA  . LEU B 1 65  ? 36.114 -10.426 -17.594 1.00 50.24  ? 65  LEU B CA  1 
ATOM   1262 C C   . LEU B 1 65  ? 37.203 -9.485  -17.061 1.00 52.69  ? 65  LEU B C   1 
ATOM   1263 O O   . LEU B 1 65  ? 36.951 -8.687  -16.156 1.00 53.60  ? 65  LEU B O   1 
ATOM   1264 C CB  . LEU B 1 65  ? 35.541 -11.284 -16.457 1.00 48.83  ? 65  LEU B CB  1 
ATOM   1265 C CG  . LEU B 1 65  ? 34.334 -12.165 -16.813 1.00 45.55  ? 65  LEU B CG  1 
ATOM   1266 C CD1 . LEU B 1 65  ? 33.877 -12.966 -15.605 1.00 45.33  ? 65  LEU B CD1 1 
ATOM   1267 C CD2 . LEU B 1 65  ? 33.181 -11.335 -17.360 1.00 44.30  ? 65  LEU B CD2 1 
ATOM   1268 N N   . SER B 1 66  ? 38.403 -9.578  -17.630 1.00 55.48  ? 66  SER B N   1 
ATOM   1269 C CA  . SER B 1 66  ? 39.504 -8.668  -17.296 1.00 60.10  ? 66  SER B CA  1 
ATOM   1270 C C   . SER B 1 66  ? 40.346 -8.375  -18.538 1.00 58.29  ? 66  SER B C   1 
ATOM   1271 O O   . SER B 1 66  ? 40.101 -8.935  -19.604 1.00 57.37  ? 66  SER B O   1 
ATOM   1272 C CB  . SER B 1 66  ? 40.374 -9.265  -16.188 1.00 62.30  ? 66  SER B CB  1 
ATOM   1273 O OG  . SER B 1 66  ? 40.964 -10.486 -16.599 1.00 67.04  ? 66  SER B OG  1 
ATOM   1274 N N   . GLY B 1 67  ? 41.329 -7.490  -18.400 1.00 59.05  ? 67  GLY B N   1 
ATOM   1275 C CA  . GLY B 1 67  ? 42.198 -7.125  -19.519 1.00 60.96  ? 67  GLY B CA  1 
ATOM   1276 C C   . GLY B 1 67  ? 41.474 -6.298  -20.566 1.00 62.64  ? 67  GLY B C   1 
ATOM   1277 O O   . GLY B 1 67  ? 40.389 -5.771  -20.311 1.00 57.44  ? 67  GLY B O   1 
ATOM   1278 N N   . ASP B 1 68  ? 42.070 -6.194  -21.752 1.00 61.98  ? 68  ASP B N   1 
ATOM   1279 C CA  . ASP B 1 68  ? 41.517 -5.358  -22.829 1.00 69.65  ? 68  ASP B CA  1 
ATOM   1280 C C   . ASP B 1 68  ? 40.274 -5.957  -23.509 1.00 60.77  ? 68  ASP B C   1 
ATOM   1281 O O   . ASP B 1 68  ? 39.521 -5.233  -24.162 1.00 55.03  ? 68  ASP B O   1 
ATOM   1282 C CB  . ASP B 1 68  ? 42.592 -5.006  -23.872 1.00 77.57  ? 68  ASP B CB  1 
ATOM   1283 C CG  . ASP B 1 68  ? 43.244 -6.230  -24.501 1.00 86.41  ? 68  ASP B CG  1 
ATOM   1284 O OD1 . ASP B 1 68  ? 43.106 -7.344  -23.951 1.00 90.47  ? 68  ASP B OD1 1 
ATOM   1285 O OD2 . ASP B 1 68  ? 43.911 -6.069  -25.545 1.00 102.84 ? 68  ASP B OD2 1 
ATOM   1286 N N   . HIS B 1 69  ? 40.060 -7.264  -23.351 1.00 56.72  ? 69  HIS B N   1 
ATOM   1287 C CA  . HIS B 1 69  ? 38.832 -7.913  -23.832 1.00 57.31  ? 69  HIS B CA  1 
ATOM   1288 C C   . HIS B 1 69  ? 37.715 -7.912  -22.782 1.00 56.26  ? 69  HIS B C   1 
ATOM   1289 O O   . HIS B 1 69  ? 36.693 -8.580  -22.968 1.00 58.28  ? 69  HIS B O   1 
ATOM   1290 C CB  . HIS B 1 69  ? 39.106 -9.362  -24.256 1.00 63.23  ? 69  HIS B CB  1 
ATOM   1291 C CG  . HIS B 1 69  ? 40.071 -9.491  -25.390 1.00 74.43  ? 69  HIS B CG  1 
ATOM   1292 N ND1 . HIS B 1 69  ? 39.675 -9.465  -26.709 0.48 80.65  ? 69  HIS B ND1 1 
ATOM   1293 C CD2 . HIS B 1 69  ? 41.414 -9.656  -25.402 1.00 79.90  ? 69  HIS B CD2 1 
ATOM   1294 C CE1 . HIS B 1 69  ? 40.734 -9.604  -27.486 1.00 83.95  ? 69  HIS B CE1 1 
ATOM   1295 N NE2 . HIS B 1 69  ? 41.802 -9.721  -26.718 1.00 89.58  ? 69  HIS B NE2 1 
ATOM   1296 N N   . SER B 1 70  ? 37.906 -7.179  -21.684 1.00 53.27  ? 70  SER B N   1 
ATOM   1297 C CA  . SER B 1 70  ? 36.934 -7.168  -20.591 1.00 52.63  ? 70  SER B CA  1 
ATOM   1298 C C   . SER B 1 70  ? 35.564 -6.735  -21.090 1.00 43.33  ? 70  SER B C   1 
ATOM   1299 O O   . SER B 1 70  ? 35.433 -5.687  -21.716 1.00 43.95  ? 70  SER B O   1 
ATOM   1300 C CB  . SER B 1 70  ? 37.382 -6.240  -19.459 1.00 56.09  ? 70  SER B CB  1 
ATOM   1301 O OG  . SER B 1 70  ? 36.450 -6.264  -18.389 1.00 53.95  ? 70  SER B OG  1 
ATOM   1302 N N   . ILE B 1 71  ? 34.549 -7.552  -20.818 1.00 41.11  ? 71  ILE B N   1 
ATOM   1303 C CA  . ILE B 1 71  ? 33.168 -7.213  -21.171 1.00 38.88  ? 71  ILE B CA  1 
ATOM   1304 C C   . ILE B 1 71  ? 32.461 -6.469  -20.034 1.00 33.93  ? 71  ILE B C   1 
ATOM   1305 O O   . ILE B 1 71  ? 31.280 -6.134  -20.148 1.00 31.52  ? 71  ILE B O   1 
ATOM   1306 C CB  . ILE B 1 71  ? 32.347 -8.461  -21.581 1.00 42.65  ? 71  ILE B CB  1 
ATOM   1307 C CG1 . ILE B 1 71  ? 32.211 -9.450  -20.413 1.00 41.82  ? 71  ILE B CG1 1 
ATOM   1308 C CG2 . ILE B 1 71  ? 32.979 -9.121  -22.800 1.00 46.84  ? 71  ILE B CG2 1 
ATOM   1309 C CD1 . ILE B 1 71  ? 31.340 -10.652 -20.712 1.00 41.77  ? 71  ILE B CD1 1 
ATOM   1310 N N   . ILE B 1 72  ? 33.189 -6.209  -18.948 1.00 36.28  ? 72  ILE B N   1 
ATOM   1311 C CA  . ILE B 1 72  ? 32.637 -5.521  -17.787 1.00 35.36  ? 72  ILE B CA  1 
ATOM   1312 C C   . ILE B 1 72  ? 32.227 -4.107  -18.182 1.00 32.21  ? 72  ILE B C   1 
ATOM   1313 O O   . ILE B 1 72  ? 33.031 -3.346  -18.722 1.00 30.87  ? 72  ILE B O   1 
ATOM   1314 C CB  . ILE B 1 72  ? 33.654 -5.450  -16.621 1.00 38.43  ? 72  ILE B CB  1 
ATOM   1315 C CG1 . ILE B 1 72  ? 33.995 -6.857  -16.099 1.00 37.21  ? 72  ILE B CG1 1 
ATOM   1316 C CG2 . ILE B 1 72  ? 33.126 -4.578  -15.485 1.00 40.40  ? 72  ILE B CG2 1 
ATOM   1317 C CD1 . ILE B 1 72  ? 32.825 -7.634  -15.522 1.00 36.12  ? 72  ILE B CD1 1 
ATOM   1318 N N   . GLY B 1 73  ? 30.966 -3.770  -17.922 1.00 31.77  ? 73  GLY B N   1 
ATOM   1319 C CA  . GLY B 1 73  ? 30.440 -2.446  -18.243 1.00 33.41  ? 73  GLY B CA  1 
ATOM   1320 C C   . GLY B 1 73  ? 29.986 -2.288  -19.685 1.00 31.39  ? 73  GLY B C   1 
ATOM   1321 O O   . GLY B 1 73  ? 29.566 -1.199  -20.083 1.00 30.20  ? 73  GLY B O   1 
ATOM   1322 N N   . ARG B 1 74  ? 30.083 -3.359  -20.473 1.00 32.41  ? 74  ARG B N   1 
ATOM   1323 C CA  . ARG B 1 74  ? 29.523 -3.375  -21.823 1.00 33.49  ? 74  ARG B CA  1 
ATOM   1324 C C   . ARG B 1 74  ? 28.093 -3.889  -21.743 1.00 30.16  ? 74  ARG B C   1 
ATOM   1325 O O   . ARG B 1 74  ? 27.688 -4.481  -20.737 1.00 29.48  ? 74  ARG B O   1 
ATOM   1326 C CB  . ARG B 1 74  ? 30.366 -4.231  -22.781 1.00 36.25  ? 74  ARG B CB  1 
ATOM   1327 C CG  . ARG B 1 74  ? 31.606 -3.517  -23.310 1.00 40.41  ? 74  ARG B CG  1 
ATOM   1328 C CD  . ARG B 1 74  ? 32.555 -4.456  -24.046 1.00 48.35  ? 74  ARG B CD  1 
ATOM   1329 N NE  . ARG B 1 74  ? 32.009 -4.976  -25.302 1.00 52.79  ? 74  ARG B NE  1 
ATOM   1330 C CZ  . ARG B 1 74  ? 32.616 -5.876  -26.079 1.00 58.38  ? 74  ARG B CZ  1 
ATOM   1331 N NH1 . ARG B 1 74  ? 33.803 -6.377  -25.741 1.00 57.15  ? 74  ARG B NH1 1 
ATOM   1332 N NH2 . ARG B 1 74  ? 32.034 -6.286  -27.203 1.00 55.46  ? 74  ARG B NH2 1 
ATOM   1333 N N   . THR B 1 75  ? 27.334 -3.655  -22.806 1.00 28.40  ? 75  THR B N   1 
ATOM   1334 C CA  . THR B 1 75  ? 25.913 -3.966  -22.818 1.00 27.49  ? 75  THR B CA  1 
ATOM   1335 C C   . THR B 1 75  ? 25.648 -5.300  -23.507 1.00 29.91  ? 75  THR B C   1 
ATOM   1336 O O   . THR B 1 75  ? 25.993 -5.494  -24.674 1.00 33.41  ? 75  THR B O   1 
ATOM   1337 C CB  . THR B 1 75  ? 25.118 -2.850  -23.509 1.00 29.09  ? 75  THR B CB  1 
ATOM   1338 O OG1 . THR B 1 75  ? 25.357 -1.617  -22.821 1.00 32.77  ? 75  THR B OG1 1 
ATOM   1339 C CG2 . THR B 1 75  ? 23.625 -3.153  -23.495 1.00 30.58  ? 75  THR B CG2 1 
ATOM   1340 N N   . LEU B 1 76  ? 25.037 -6.215  -22.765 1.00 27.37  ? 76  LEU B N   1 
ATOM   1341 C CA  . LEU B 1 76  ? 24.585 -7.484  -23.319 1.00 27.53  ? 76  LEU B CA  1 
ATOM   1342 C C   . LEU B 1 76  ? 23.215 -7.269  -23.934 1.00 28.42  ? 76  LEU B C   1 
ATOM   1343 O O   . LEU B 1 76  ? 22.350 -6.658  -23.308 1.00 29.51  ? 76  LEU B O   1 
ATOM   1344 C CB  . LEU B 1 76  ? 24.496 -8.546  -22.222 1.00 27.70  ? 76  LEU B CB  1 
ATOM   1345 C CG  . LEU B 1 76  ? 24.138 -9.965  -22.677 1.00 28.11  ? 76  LEU B CG  1 
ATOM   1346 C CD1 . LEU B 1 76  ? 25.210 -10.535 -23.594 1.00 30.25  ? 76  LEU B CD1 1 
ATOM   1347 C CD2 . LEU B 1 76  ? 23.936 -10.869 -21.471 1.00 31.46  ? 76  LEU B CD2 1 
ATOM   1348 N N   . VAL B 1 77  ? 23.019 -7.767  -25.152 1.00 25.03  ? 77  VAL B N   1 
ATOM   1349 C CA  . VAL B 1 77  ? 21.740 -7.618  -25.844 1.00 32.79  ? 77  VAL B CA  1 
ATOM   1350 C C   . VAL B 1 77  ? 21.227 -8.954  -26.374 1.00 34.60  ? 77  VAL B C   1 
ATOM   1351 O O   . VAL B 1 77  ? 22.010 -9.838  -26.732 1.00 35.23  ? 77  VAL B O   1 
ATOM   1352 C CB  . VAL B 1 77  ? 21.828 -6.609  -27.016 1.00 38.78  ? 77  VAL B CB  1 
ATOM   1353 C CG1 . VAL B 1 77  ? 22.498 -5.315  -26.571 1.00 40.25  ? 77  VAL B CG1 1 
ATOM   1354 C CG2 . VAL B 1 77  ? 22.577 -7.196  -28.202 1.00 42.69  ? 77  VAL B CG2 1 
ATOM   1355 N N   . VAL B 1 78  ? 19.905 -9.086  -26.416 1.00 37.21  ? 78  VAL B N   1 
ATOM   1356 C CA  . VAL B 1 78  ? 19.256 -10.198 -27.101 1.00 40.35  ? 78  VAL B CA  1 
ATOM   1357 C C   . VAL B 1 78  ? 18.254 -9.616  -28.095 1.00 43.29  ? 78  VAL B C   1 
ATOM   1358 O O   . VAL B 1 78  ? 17.542 -8.661  -27.779 1.00 42.17  ? 78  VAL B O   1 
ATOM   1359 C CB  . VAL B 1 78  ? 18.573 -11.184 -26.119 1.00 39.47  ? 78  VAL B CB  1 
ATOM   1360 C CG1 . VAL B 1 78  ? 17.512 -10.494 -25.271 1.00 38.79  ? 78  VAL B CG1 1 
ATOM   1361 C CG2 . VAL B 1 78  ? 17.974 -12.367 -26.868 1.00 38.69  ? 78  VAL B CG2 1 
ATOM   1362 N N   . HIS B 1 79  ? 18.224 -10.175 -29.301 1.00 45.84  ? 79  HIS B N   1 
ATOM   1363 C CA  . HIS B 1 79  ? 17.267 -9.752  -30.321 1.00 52.20  ? 79  HIS B CA  1 
ATOM   1364 C C   . HIS B 1 79  ? 15.893 -10.338 -30.020 1.00 53.39  ? 79  HIS B C   1 
ATOM   1365 O O   . HIS B 1 79  ? 15.732 -11.557 -29.992 1.00 52.98  ? 79  HIS B O   1 
ATOM   1366 C CB  . HIS B 1 79  ? 17.728 -10.193 -31.711 1.00 55.02  ? 79  HIS B CB  1 
ATOM   1367 C CG  . HIS B 1 79  ? 18.841 -9.363  -32.268 1.00 59.81  ? 79  HIS B CG  1 
ATOM   1368 N ND1 . HIS B 1 79  ? 18.883 -8.966  -33.587 1.00 65.02  ? 79  HIS B ND1 1 
ATOM   1369 C CD2 . HIS B 1 79  ? 19.944 -8.839  -31.682 1.00 60.60  ? 79  HIS B CD2 1 
ATOM   1370 C CE1 . HIS B 1 79  ? 19.971 -8.245  -33.793 1.00 67.06  ? 79  HIS B CE1 1 
ATOM   1371 N NE2 . HIS B 1 79  ? 20.630 -8.151  -32.653 1.00 63.47  ? 79  HIS B NE2 1 
ATOM   1372 N N   . GLU B 1 80  ? 14.911 -9.468  -29.793 1.00 55.97  ? 80  GLU B N   1 
ATOM   1373 C CA  . GLU B 1 80  ? 13.536 -9.899  -29.529 1.00 55.47  ? 80  GLU B CA  1 
ATOM   1374 C C   . GLU B 1 80  ? 12.867 -10.470 -30.782 1.00 62.15  ? 80  GLU B C   1 
ATOM   1375 O O   . GLU B 1 80  ? 11.933 -11.267 -30.681 1.00 62.87  ? 80  GLU B O   1 
ATOM   1376 C CB  . GLU B 1 80  ? 12.705 -8.744  -28.964 1.00 58.33  ? 80  GLU B CB  1 
ATOM   1377 C CG  . GLU B 1 80  ? 13.208 -8.235  -27.620 1.00 60.77  ? 80  GLU B CG  1 
ATOM   1378 C CD  . GLU B 1 80  ? 12.256 -7.256  -26.952 1.00 67.53  ? 80  GLU B CD  1 
ATOM   1379 O OE1 . GLU B 1 80  ? 11.204 -6.930  -27.543 1.00 73.04  ? 80  GLU B OE1 1 
ATOM   1380 O OE2 . GLU B 1 80  ? 12.565 -6.811  -25.826 1.00 69.95  ? 80  GLU B OE2 1 
ATOM   1381 N N   . LYS B 1 81  ? 13.339 -10.055 -31.957 1.00 65.93  ? 81  LYS B N   1 
ATOM   1382 C CA  . LYS B 1 81  ? 12.911 -10.660 -33.217 1.00 73.52  ? 81  LYS B CA  1 
ATOM   1383 C C   . LYS B 1 81  ? 13.613 -12.005 -33.383 1.00 74.46  ? 81  LYS B C   1 
ATOM   1384 O O   . LYS B 1 81  ? 14.831 -12.101 -33.215 1.00 68.85  ? 81  LYS B O   1 
ATOM   1385 C CB  . LYS B 1 81  ? 13.242 -9.743  -34.398 1.00 80.72  ? 81  LYS B CB  1 
ATOM   1386 C CG  . LYS B 1 81  ? 12.732 -10.240 -35.744 1.00 89.05  ? 81  LYS B CG  1 
ATOM   1387 C CD  . LYS B 1 81  ? 13.024 -9.246  -36.861 1.00 98.72  ? 81  LYS B CD  1 
ATOM   1388 C CE  . LYS B 1 81  ? 12.013 -8.110  -36.902 1.00 103.16 ? 81  LYS B CE  1 
ATOM   1389 N NZ  . LYS B 1 81  ? 10.701 -8.534  -37.468 1.00 106.89 ? 81  LYS B NZ  1 
ATOM   1390 N N   . ALA B 1 82  ? 12.842 -13.037 -33.714 1.00 75.05  ? 82  ALA B N   1 
ATOM   1391 C CA  . ALA B 1 82  ? 13.384 -14.386 -33.870 1.00 78.10  ? 82  ALA B CA  1 
ATOM   1392 C C   . ALA B 1 82  ? 14.155 -14.534 -35.183 1.00 82.46  ? 82  ALA B C   1 
ATOM   1393 O O   . ALA B 1 82  ? 13.922 -13.791 -36.137 1.00 81.77  ? 82  ALA B O   1 
ATOM   1394 C CB  . ALA B 1 82  ? 12.267 -15.418 -33.796 1.00 78.51  ? 82  ALA B CB  1 
ATOM   1395 N N   . GLY B 1 83  ? 15.075 -15.496 -35.215 1.00 84.93  ? 83  GLY B N   1 
ATOM   1396 C CA  . GLY B 1 83  ? 15.831 -15.820 -36.426 1.00 88.40  ? 83  GLY B CA  1 
ATOM   1397 C C   . GLY B 1 83  ? 17.159 -15.094 -36.539 1.00 92.64  ? 83  GLY B C   1 
ATOM   1398 O O   . GLY B 1 83  ? 17.514 -14.283 -35.683 1.00 87.47  ? 83  GLY B O   1 
ATOM   1399 N N   . ALA B 1 84  ? 17.887 -15.390 -37.614 1.00 92.86  ? 84  ALA B N   1 
ATOM   1400 C CA  . ALA B 1 84  ? 19.200 -14.788 -37.868 1.00 100.35 ? 84  ALA B CA  1 
ATOM   1401 C C   . ALA B 1 84  ? 19.105 -13.360 -38.411 1.00 103.05 ? 84  ALA B C   1 
ATOM   1402 O O   . ALA B 1 84  ? 20.111 -12.650 -38.463 1.00 102.19 ? 84  ALA B O   1 
ATOM   1403 C CB  . ALA B 1 84  ? 19.998 -15.658 -38.829 1.00 103.04 ? 84  ALA B CB  1 
ATOM   1404 N N   . GLY B 1 85  ? 17.907 -12.948 -38.824 1.00 107.83 ? 85  GLY B N   1 
ATOM   1405 C CA  . GLY B 1 85  ? 17.685 -11.601 -39.341 1.00 110.95 ? 85  GLY B CA  1 
ATOM   1406 C C   . GLY B 1 85  ? 17.891 -10.528 -38.288 1.00 112.42 ? 85  GLY B C   1 
ATOM   1407 O O   . GLY B 1 85  ? 17.308 -10.591 -37.204 1.00 112.92 ? 85  GLY B O   1 
ATOM   1408 N N   . ALA B 1 86  ? 18.729 -9.544  -38.611 1.00 114.73 ? 86  ALA B N   1 
ATOM   1409 C CA  . ALA B 1 86  ? 19.020 -8.438  -37.703 1.00 114.82 ? 86  ALA B CA  1 
ATOM   1410 C C   . ALA B 1 86  ? 17.775 -7.583  -37.483 1.00 110.54 ? 86  ALA B C   1 
ATOM   1411 O O   . ALA B 1 86  ? 17.039 -7.292  -38.427 1.00 111.45 ? 86  ALA B O   1 
ATOM   1412 C CB  . ALA B 1 86  ? 20.156 -7.588  -38.252 1.00 115.05 ? 86  ALA B CB  1 
ATOM   1413 N N   . GLY B 1 87  ? 17.551 -7.188  -36.232 1.00 103.36 ? 87  GLY B N   1 
ATOM   1414 C CA  . GLY B 1 87  ? 16.356 -6.442  -35.846 1.00 101.14 ? 87  GLY B CA  1 
ATOM   1415 C C   . GLY B 1 87  ? 16.673 -5.290  -34.915 1.00 96.18  ? 87  GLY B C   1 
ATOM   1416 O O   . GLY B 1 87  ? 17.746 -5.240  -34.310 1.00 94.42  ? 87  GLY B O   1 
ATOM   1417 N N   . SER B 1 88  ? 15.723 -4.366  -34.800 1.00 93.59  ? 88  SER B N   1 
ATOM   1418 C CA  . SER B 1 88  ? 15.899 -3.151  -34.005 1.00 86.92  ? 88  SER B CA  1 
ATOM   1419 C C   . SER B 1 88  ? 15.435 -3.321  -32.557 1.00 79.43  ? 88  SER B C   1 
ATOM   1420 O O   . SER B 1 88  ? 15.887 -2.596  -31.671 1.00 73.03  ? 88  SER B O   1 
ATOM   1421 C CB  . SER B 1 88  ? 15.135 -1.996  -34.653 1.00 85.32  ? 88  SER B CB  1 
ATOM   1422 O OG  . SER B 1 88  ? 15.548 -1.799  -35.993 1.00 85.34  ? 88  SER B OG  1 
ATOM   1423 N N   . ARG B 1 89  ? 14.552 -4.289  -32.320 1.00 78.11  ? 89  ARG B N   1 
ATOM   1424 C CA  . ARG B 1 89  ? 13.932 -4.477  -31.009 1.00 73.33  ? 89  ARG B CA  1 
ATOM   1425 C C   . ARG B 1 89  ? 14.769 -5.381  -30.111 1.00 64.21  ? 89  ARG B C   1 
ATOM   1426 O O   . ARG B 1 89  ? 15.075 -6.509  -30.481 1.00 58.70  ? 89  ARG B O   1 
ATOM   1427 C CB  . ARG B 1 89  ? 12.539 -5.065  -31.185 1.00 80.17  ? 89  ARG B CB  1 
ATOM   1428 C CG  . ARG B 1 89  ? 11.534 -4.565  -30.172 1.00 86.28  ? 89  ARG B CG  1 
ATOM   1429 C CD  . ARG B 1 89  ? 10.130 -4.674  -30.732 1.00 94.80  ? 89  ARG B CD  1 
ATOM   1430 N NE  . ARG B 1 89  ? 9.154  -3.996  -29.883 1.00 101.91 ? 89  ARG B NE  1 
ATOM   1431 C CZ  . ARG B 1 89  ? 8.537  -2.853  -30.183 1.00 109.49 ? 89  ARG B CZ  1 
ATOM   1432 N NH1 . ARG B 1 89  ? 8.773  -2.227  -31.330 1.00 110.42 ? 89  ARG B NH1 1 
ATOM   1433 N NH2 . ARG B 1 89  ? 7.665  -2.337  -29.328 1.00 112.11 ? 89  ARG B NH2 1 
ATOM   1434 N N   . LEU B 1 90  ? 15.127 -4.887  -28.929 1.00 58.99  ? 90  LEU B N   1 
ATOM   1435 C CA  . LEU B 1 90  ? 16.045 -5.606  -28.055 1.00 56.41  ? 90  LEU B CA  1 
ATOM   1436 C C   . LEU B 1 90  ? 15.662 -5.583  -26.589 1.00 51.20  ? 90  LEU B C   1 
ATOM   1437 O O   . LEU B 1 90  ? 14.998 -4.664  -26.116 1.00 54.05  ? 90  LEU B O   1 
ATOM   1438 C CB  . LEU B 1 90  ? 17.442 -4.999  -28.142 1.00 56.67  ? 90  LEU B CB  1 
ATOM   1439 C CG  . LEU B 1 90  ? 18.009 -4.531  -29.476 1.00 56.06  ? 90  LEU B CG  1 
ATOM   1440 C CD1 . LEU B 1 90  ? 19.126 -3.542  -29.200 1.00 56.28  ? 90  LEU B CD1 1 
ATOM   1441 C CD2 . LEU B 1 90  ? 18.516 -5.706  -30.294 1.00 56.00  ? 90  LEU B CD2 1 
ATOM   1442 N N   . ALA B 1 91  ? 16.124 -6.597  -25.872 1.00 43.18  ? 91  ALA B N   1 
ATOM   1443 C CA  . ALA B 1 91  ? 16.228 -6.535  -24.431 1.00 39.38  ? 91  ALA B CA  1 
ATOM   1444 C C   . ALA B 1 91  ? 17.707 -6.479  -24.122 1.00 37.96  ? 91  ALA B C   1 
ATOM   1445 O O   . ALA B 1 91  ? 18.498 -7.172  -24.758 1.00 37.01  ? 91  ALA B O   1 
ATOM   1446 C CB  . ALA B 1 91  ? 15.598 -7.750  -23.787 1.00 37.86  ? 91  ALA B CB  1 
ATOM   1447 N N   . SER B 1 92  ? 18.081 -5.651  -23.155 1.00 34.96  ? 92  SER B N   1 
ATOM   1448 C CA  . SER B 1 92  ? 19.482 -5.481  -22.821 1.00 33.13  ? 92  SER B CA  1 
ATOM   1449 C C   . SER B 1 92  ? 19.713 -5.051  -21.387 1.00 30.70  ? 92  SER B C   1 
ATOM   1450 O O   . SER B 1 92  ? 18.791 -4.692  -20.656 1.00 30.76  ? 92  SER B O   1 
ATOM   1451 C CB  . SER B 1 92  ? 20.143 -4.485  -23.778 1.00 32.34  ? 92  SER B CB  1 
ATOM   1452 O OG  . SER B 1 92  ? 19.457 -3.257  -23.800 1.00 33.33  ? 92  SER B OG  1 
ATOM   1453 N N   . GLY B 1 93  ? 20.977 -5.111  -21.000 1.00 27.73  ? 93  GLY B N   1 
ATOM   1454 C CA  . GLY B 1 93  ? 21.404 -4.682  -19.682 1.00 26.87  ? 93  GLY B CA  1 
ATOM   1455 C C   . GLY B 1 93  ? 22.908 -4.571  -19.639 1.00 25.46  ? 93  GLY B C   1 
ATOM   1456 O O   . GLY B 1 93  ? 23.607 -5.247  -20.394 1.00 26.80  ? 93  GLY B O   1 
ATOM   1457 N N   . VAL B 1 94  ? 23.403 -3.720  -18.748 1.00 25.10  ? 94  VAL B N   1 
ATOM   1458 C CA  . VAL B 1 94  ? 24.840 -3.504  -18.607 1.00 24.92  ? 94  VAL B CA  1 
ATOM   1459 C C   . VAL B 1 94  ? 25.427 -4.638  -17.776 1.00 24.98  ? 94  VAL B C   1 
ATOM   1460 O O   . VAL B 1 94  ? 24.849 -5.044  -16.766 1.00 27.03  ? 94  VAL B O   1 
ATOM   1461 C CB  . VAL B 1 94  ? 25.153 -2.151  -17.932 1.00 25.97  ? 94  VAL B CB  1 
ATOM   1462 C CG1 . VAL B 1 94  ? 26.657 -1.938  -17.812 1.00 26.67  ? 94  VAL B CG1 1 
ATOM   1463 C CG2 . VAL B 1 94  ? 24.519 -1.003  -18.708 1.00 29.15  ? 94  VAL B CG2 1 
ATOM   1464 N N   . ILE B 1 95  ? 26.574 -5.149  -18.210 1.00 24.04  ? 95  ILE B N   1 
ATOM   1465 C CA  . ILE B 1 95  ? 27.250 -6.228  -17.502 1.00 24.90  ? 95  ILE B CA  1 
ATOM   1466 C C   . ILE B 1 95  ? 27.973 -5.644  -16.292 1.00 26.60  ? 95  ILE B C   1 
ATOM   1467 O O   . ILE B 1 95  ? 28.942 -4.899  -16.444 1.00 30.01  ? 95  ILE B O   1 
ATOM   1468 C CB  . ILE B 1 95  ? 28.238 -6.968  -18.426 1.00 23.09  ? 95  ILE B CB  1 
ATOM   1469 C CG1 . ILE B 1 95  ? 27.486 -7.632  -19.585 1.00 26.37  ? 95  ILE B CG1 1 
ATOM   1470 C CG2 . ILE B 1 95  ? 29.028 -8.008  -17.647 1.00 20.14  ? 95  ILE B CG2 1 
ATOM   1471 C CD1 . ILE B 1 95  ? 28.347 -7.935  -20.789 1.00 30.03  ? 95  ILE B CD1 1 
ATOM   1472 N N   . GLY B 1 96  ? 27.492 -5.982  -15.097 1.00 25.23  ? 96  GLY B N   1 
ATOM   1473 C CA  . GLY B 1 96  ? 28.030 -5.437  -13.851 1.00 29.53  ? 96  GLY B CA  1 
ATOM   1474 C C   . GLY B 1 96  ? 28.833 -6.459  -13.073 1.00 32.33  ? 96  GLY B C   1 
ATOM   1475 O O   . GLY B 1 96  ? 28.670 -7.664  -13.274 1.00 29.58  ? 96  GLY B O   1 
ATOM   1476 N N   . ILE B 1 97  ? 29.701 -5.999  -12.180 1.00 39.00  ? 97  ILE B N   1 
ATOM   1477 C CA  . ILE B 1 97  ? 30.512 -6.946  -11.408 1.00 41.39  ? 97  ILE B CA  1 
ATOM   1478 C C   . ILE B 1 97  ? 29.760 -7.380  -10.148 1.00 44.13  ? 97  ILE B C   1 
ATOM   1479 O O   . ILE B 1 97  ? 29.157 -6.566  -9.450  1.00 45.76  ? 97  ILE B O   1 
ATOM   1480 C CB  . ILE B 1 97  ? 31.985 -6.488  -11.127 1.00 44.64  ? 97  ILE B CB  1 
ATOM   1481 C CG1 . ILE B 1 97  ? 32.215 -6.020  -9.689  1.00 48.26  ? 97  ILE B CG1 1 
ATOM   1482 C CG2 . ILE B 1 97  ? 32.464 -5.435  -12.113 1.00 46.30  ? 97  ILE B CG2 1 
ATOM   1483 C CD1 . ILE B 1 97  ? 31.527 -4.727  -9.337  1.00 49.95  ? 97  ILE B CD1 1 
ATOM   1484 N N   . ALA B 1 98  ? 29.789 -8.684  -9.898  1.00 44.12  ? 98  ALA B N   1 
ATOM   1485 C CA  . ALA B 1 98  ? 29.134 -9.290  -8.742  1.00 50.56  ? 98  ALA B CA  1 
ATOM   1486 C C   . ALA B 1 98  ? 30.126 -9.336  -7.585  1.00 56.93  ? 98  ALA B C   1 
ATOM   1487 O O   . ALA B 1 98  ? 29.857 -8.824  -6.495  1.00 60.64  ? 98  ALA B O   1 
ATOM   1488 C CB  . ALA B 1 98  ? 28.651 -10.690 -9.089  1.00 48.59  ? 98  ALA B CB  1 
ATOM   1489 N N   . GLN B 1 99  ? 31.272 -9.960  -7.835  1.00 57.34  ? 99  GLN B N   1 
ATOM   1490 C CA  . GLN B 1 99  ? 32.400 -9.907  -6.914  1.00 67.30  ? 99  GLN B CA  1 
ATOM   1491 C C   . GLN B 1 99  ? 33.682 -9.649  -7.705  1.00 75.55  ? 99  GLN B C   1 
ATOM   1492 O O   . GLN B 1 99  ? 33.951 -10.322 -8.703  1.00 77.00  ? 99  GLN B O   1 
ATOM   1493 C CB  . GLN B 1 99  ? 32.506 -11.190 -6.080  1.00 75.18  ? 99  GLN B CB  1 
ATOM   1494 C CG  . GLN B 1 99  ? 32.540 -12.490 -6.874  1.00 79.46  ? 99  GLN B CG  1 
ATOM   1495 C CD  . GLN B 1 99  ? 32.749 -13.710 -5.991  1.00 85.54  ? 99  GLN B CD  1 
ATOM   1496 O OE1 . GLN B 1 99  ? 31.957 -14.653 -6.022  1.00 89.07  ? 99  GLN B OE1 1 
ATOM   1497 N NE2 . GLN B 1 99  ? 33.816 -13.696 -5.195  1.00 87.59  ? 99  GLN B NE2 1 
ATOM   1498 N N   . ALA B 1 100 ? 34.457 -8.661  -7.261  1.00 77.51  ? 100 ALA B N   1 
ATOM   1499 C CA  . ALA B 1 100 ? 35.694 -8.274  -7.940  1.00 82.57  ? 100 ALA B CA  1 
ATOM   1500 C C   . ALA B 1 100 ? 36.788 -9.315  -7.713  1.00 94.24  ? 100 ALA B C   1 
ATOM   1501 O O   . ALA B 1 100 ? 36.588 -10.290 -6.982  1.00 104.91 ? 100 ALA B O   1 
ATOM   1502 C CB  . ALA B 1 100 ? 36.153 -6.903  -7.458  1.00 78.04  ? 100 ALA B CB  1 
ATOM   1503 N N   . GLY B 1 101 ? 37.942 -9.106  -8.341  1.00 102.22 ? 101 GLY B N   1 
ATOM   1504 C CA  . GLY B 1 101 ? 39.060 -10.037 -8.225  1.00 111.18 ? 101 GLY B CA  1 
ATOM   1505 C C   . GLY B 1 101 ? 39.640 -10.075 -6.818  1.00 114.04 ? 101 GLY B C   1 
ATOM   1506 O O   . GLY B 1 101 ? 39.450 -9.133  -6.048  1.00 116.63 ? 101 GLY B O   1 
ATOM   1507 N N   . ALA B 1 102 ? 40.357 -11.142 -6.463  1.00 116.74 ? 102 ALA B N   1 
ATOM   1508 C CA  . ALA B 1 102 ? 40.674 -12.261 -7.357  1.00 122.47 ? 102 ALA B CA  1 
ATOM   1509 C C   . ALA B 1 102 ? 40.501 -13.585 -6.602  1.00 124.50 ? 102 ALA B C   1 
ATOM   1510 O O   . ALA B 1 102 ? 40.334 -13.569 -5.383  1.00 115.50 ? 102 ALA B O   1 
ATOM   1511 C CB  . ALA B 1 102 ? 42.100 -12.115 -7.869  1.00 124.88 ? 102 ALA B CB  1 
ATOM   1512 N N   . GLY B 1 103 ? 40.503 -14.731 -7.289  1.00 129.42 ? 103 GLY B N   1 
ATOM   1513 C CA  . GLY B 1 103 ? 40.521 -14.839 -8.752  1.00 129.35 ? 103 GLY B CA  1 
ATOM   1514 C C   . GLY B 1 103 ? 39.231 -15.493 -9.255  1.00 122.32 ? 103 GLY B C   1 
ATOM   1515 O O   . GLY B 1 103 ? 39.180 -16.000 -10.378 1.00 122.58 ? 103 GLY B O   1 
ATOM   1516 N N   . ALA B 1 104 ? 38.195 -15.469 -8.418  1.00 105.55 ? 104 ALA B N   1 
ATOM   1517 C CA  . ALA B 1 104 ? 36.877 -15.980 -8.778  1.00 94.72  ? 104 ALA B CA  1 
ATOM   1518 C C   . ALA B 1 104 ? 35.986 -14.807 -9.180  1.00 89.79  ? 104 ALA B C   1 
ATOM   1519 O O   . ALA B 1 104 ? 34.994 -14.507 -8.513  1.00 77.56  ? 104 ALA B O   1 
ATOM   1520 C CB  . ALA B 1 104 ? 36.271 -16.748 -7.612  1.00 100.53 ? 104 ALA B CB  1 
ATOM   1521 N N   . THR B 1 105 ? 36.358 -14.144 -10.273 1.00 78.28  ? 105 THR B N   1 
ATOM   1522 C CA  . THR B 1 105 ? 35.641 -12.958 -10.744 1.00 68.04  ? 105 THR B CA  1 
ATOM   1523 C C   . THR B 1 105 ? 34.303 -13.342 -11.387 1.00 59.59  ? 105 THR B C   1 
ATOM   1524 O O   . THR B 1 105 ? 34.229 -14.282 -12.183 1.00 61.01  ? 105 THR B O   1 
ATOM   1525 C CB  . THR B 1 105 ? 36.501 -12.110 -11.715 1.00 75.59  ? 105 THR B CB  1 
ATOM   1526 O OG1 . THR B 1 105 ? 35.866 -10.848 -11.944 1.00 76.58  ? 105 THR B OG1 1 
ATOM   1527 C CG2 . THR B 1 105 ? 36.726 -12.817 -13.056 1.00 86.32  ? 105 THR B CG2 1 
ATOM   1528 N N   . LYS B 1 106 ? 33.248 -12.619 -11.019 1.00 46.95  ? 106 LYS B N   1 
ATOM   1529 C CA  . LYS B 1 106 ? 31.901 -12.903 -11.510 1.00 41.28  ? 106 LYS B CA  1 
ATOM   1530 C C   . LYS B 1 106 ? 31.206 -11.626 -11.954 1.00 39.48  ? 106 LYS B C   1 
ATOM   1531 O O   . LYS B 1 106 ? 31.436 -10.553 -11.392 1.00 41.08  ? 106 LYS B O   1 
ATOM   1532 C CB  . LYS B 1 106 ? 31.075 -13.591 -10.426 1.00 43.08  ? 106 LYS B CB  1 
ATOM   1533 C CG  . LYS B 1 106 ? 31.698 -14.878 -9.910  1.00 46.35  ? 106 LYS B CG  1 
ATOM   1534 C CD  . LYS B 1 106 ? 30.795 -15.569 -8.906  1.00 48.50  ? 106 LYS B CD  1 
ATOM   1535 C CE  . LYS B 1 106 ? 31.456 -16.797 -8.304  1.00 58.32  ? 106 LYS B CE  1 
ATOM   1536 N NZ  . LYS B 1 106 ? 31.471 -17.942 -9.255  1.00 60.02  ? 106 LYS B NZ  1 
ATOM   1537 N N   . ALA B 1 107 ? 30.354 -11.751 -12.966 1.00 34.56  ? 107 ALA B N   1 
ATOM   1538 C CA  . ALA B 1 107 ? 29.614 -10.611 -13.490 1.00 29.02  ? 107 ALA B CA  1 
ATOM   1539 C C   . ALA B 1 107 ? 28.174 -11.006 -13.810 1.00 27.52  ? 107 ALA B C   1 
ATOM   1540 O O   . ALA B 1 107 ? 27.880 -12.181 -14.076 1.00 30.44  ? 107 ALA B O   1 
ATOM   1541 C CB  . ALA B 1 107 ? 30.313 -10.047 -14.717 1.00 31.92  ? 107 ALA B CB  1 
ATOM   1542 N N   . VAL B 1 108 ? 27.275 -10.028 -13.754 1.00 25.86  ? 108 VAL B N   1 
ATOM   1543 C CA  . VAL B 1 108 ? 25.850 -10.267 -13.977 1.00 25.34  ? 108 VAL B CA  1 
ATOM   1544 C C   . VAL B 1 108 ? 25.249 -9.184  -14.870 1.00 24.36  ? 108 VAL B C   1 
ATOM   1545 O O   . VAL B 1 108 ? 25.560 -7.999  -14.718 1.00 25.43  ? 108 VAL B O   1 
ATOM   1546 C CB  . VAL B 1 108 ? 25.066 -10.321 -12.645 1.00 27.38  ? 108 VAL B CB  1 
ATOM   1547 C CG1 . VAL B 1 108 ? 23.590 -10.617 -12.898 1.00 24.93  ? 108 VAL B CG1 1 
ATOM   1548 C CG2 . VAL B 1 108 ? 25.657 -11.373 -11.715 1.00 30.34  ? 108 VAL B CG2 1 
ATOM   1549 N N   . ALA B 1 109 ? 24.402 -9.607  -15.805 1.00 25.73  ? 109 ALA B N   1 
ATOM   1550 C CA  . ALA B 1 109 ? 23.619 -8.697  -16.640 1.00 23.69  ? 109 ALA B CA  1 
ATOM   1551 C C   . ALA B 1 109 ? 22.137 -8.980  -16.423 1.00 22.49  ? 109 ALA B C   1 
ATOM   1552 O O   . ALA B 1 109 ? 21.691 -10.111 -16.620 1.00 25.04  ? 109 ALA B O   1 
ATOM   1553 C CB  . ALA B 1 109 ? 23.972 -8.882  -18.103 1.00 25.90  ? 109 ALA B CB  1 
ATOM   1554 N N   . VAL B 1 110 ? 21.392 -7.961  -15.996 1.00 22.82  ? 110 VAL B N   1 
ATOM   1555 C CA  . VAL B 1 110 ? 19.935 -8.041  -15.888 1.00 24.74  ? 110 VAL B CA  1 
ATOM   1556 C C   . VAL B 1 110 ? 19.354 -7.500  -17.187 1.00 24.04  ? 110 VAL B C   1 
ATOM   1557 O O   . VAL B 1 110 ? 19.488 -6.310  -17.482 1.00 25.16  ? 110 VAL B O   1 
ATOM   1558 C CB  . VAL B 1 110 ? 19.398 -7.215  -14.699 1.00 26.55  ? 110 VAL B CB  1 
ATOM   1559 C CG1 . VAL B 1 110 ? 17.876 -7.292  -14.620 1.00 24.55  ? 110 VAL B CG1 1 
ATOM   1560 C CG2 . VAL B 1 110 ? 20.029 -7.679  -13.393 1.00 29.82  ? 110 VAL B CG2 1 
ATOM   1561 N N   . LEU B 1 111 ? 18.723 -8.378  -17.962 1.00 26.14  ? 111 LEU B N   1 
ATOM   1562 C CA  . LEU B 1 111 ? 18.190 -8.026  -19.272 1.00 26.22  ? 111 LEU B CA  1 
ATOM   1563 C C   . LEU B 1 111 ? 16.749 -7.571  -19.156 1.00 28.32  ? 111 LEU B C   1 
ATOM   1564 O O   . LEU B 1 111 ? 15.922 -8.248  -18.540 1.00 29.24  ? 111 LEU B O   1 
ATOM   1565 C CB  . LEU B 1 111 ? 18.260 -9.229  -20.216 1.00 25.83  ? 111 LEU B CB  1 
ATOM   1566 C CG  . LEU B 1 111 ? 19.648 -9.813  -20.492 1.00 25.94  ? 111 LEU B CG  1 
ATOM   1567 C CD1 . LEU B 1 111 ? 19.531 -11.057 -21.359 1.00 28.47  ? 111 LEU B CD1 1 
ATOM   1568 C CD2 . LEU B 1 111 ? 20.550 -8.792  -21.162 1.00 27.71  ? 111 LEU B CD2 1 
ATOM   1569 N N   . LYS B 1 112 ? 16.454 -6.421  -19.755 1.00 31.47  ? 112 LYS B N   1 
ATOM   1570 C CA  . LYS B 1 112 ? 15.103 -5.886  -19.794 1.00 36.30  ? 112 LYS B CA  1 
ATOM   1571 C C   . LYS B 1 112 ? 14.829 -5.256  -21.154 1.00 37.27  ? 112 LYS B C   1 
ATOM   1572 O O   . LYS B 1 112 ? 15.701 -4.604  -21.730 1.00 35.05  ? 112 LYS B O   1 
ATOM   1573 C CB  . LYS B 1 112 ? 14.907 -4.860  -18.677 1.00 43.10  ? 112 LYS B CB  1 
ATOM   1574 C CG  . LYS B 1 112 ? 15.010 -5.466  -17.286 1.00 48.37  ? 112 LYS B CG  1 
ATOM   1575 C CD  . LYS B 1 112 ? 14.656 -4.477  -16.189 1.00 55.99  ? 112 LYS B CD  1 
ATOM   1576 C CE  . LYS B 1 112 ? 14.772 -5.129  -14.820 1.00 61.47  ? 112 LYS B CE  1 
ATOM   1577 N NZ  . LYS B 1 112 ? 14.294 -4.242  -13.725 1.00 67.73  ? 112 LYS B NZ  1 
ATOM   1578 N N   . GLY B 1 113 ? 13.624 -5.481  -21.671 1.00 41.58  ? 113 GLY B N   1 
ATOM   1579 C CA  . GLY B 1 113 ? 13.177 -4.862  -22.916 1.00 50.02  ? 113 GLY B CA  1 
ATOM   1580 C C   . GLY B 1 113 ? 12.413 -3.590  -22.611 1.00 60.45  ? 113 GLY B C   1 
ATOM   1581 O O   . GLY B 1 113 ? 12.918 -2.713  -21.907 1.00 63.77  ? 113 GLY B O   1 
ATOM   1582 N N   . ASP B 1 114 ? 11.197 -3.492  -23.144 1.00 75.27  ? 114 ASP B N   1 
ATOM   1583 C CA  . ASP B 1 114 ? 10.298 -2.369  -22.865 1.00 84.98  ? 114 ASP B CA  1 
ATOM   1584 C C   . ASP B 1 114 ? 8.852  -2.852  -22.763 1.00 96.16  ? 114 ASP B C   1 
ATOM   1585 O O   . ASP B 1 114 ? 8.219  -2.722  -21.713 1.00 103.95 ? 114 ASP B O   1 
ATOM   1586 C CB  . ASP B 1 114 ? 10.417 -1.294  -23.953 1.00 90.83  ? 114 ASP B CB  1 
ATOM   1587 C CG  . ASP B 1 114 ? 11.700 -0.486  -23.844 1.00 90.04  ? 114 ASP B CG  1 
ATOM   1588 O OD1 . ASP B 1 114 ? 12.011 0.001   -22.736 1.00 87.89  ? 114 ASP B OD1 1 
ATOM   1589 O OD2 . ASP B 1 114 ? 12.393 -0.328  -24.871 1.00 91.67  ? 114 ASP B OD2 1 
ATOM   1590 N N   . GLY B 1 115 ? 8.338  -3.411  -23.855 1.00 104.62 ? 115 GLY B N   1 
ATOM   1591 C CA  . GLY B 1 115 ? 6.967  -3.916  -23.892 1.00 108.65 ? 115 GLY B CA  1 
ATOM   1592 C C   . GLY B 1 115 ? 6.575  -4.455  -25.255 1.00 113.68 ? 115 GLY B C   1 
ATOM   1593 O O   . GLY B 1 115 ? 6.462  -3.704  -26.225 1.00 111.94 ? 115 GLY B O   1 
ATOM   1594 O OXT . GLY B 1 115 ? 6.359  -5.655  -25.423 1.00 111.60 ? 115 GLY B OXT 1 
HETATM 1595 O O   . HOH C 2 .   ? 27.344 -16.404 5.756   1.00 47.38  ? 201 HOH A O   1 
HETATM 1596 O O   . HOH C 2 .   ? 16.003 -4.847  11.068  1.00 39.09  ? 202 HOH A O   1 
HETATM 1597 O O   . HOH C 2 .   ? 15.503 -5.996  6.179   1.00 43.67  ? 203 HOH A O   1 
HETATM 1598 O O   . HOH C 2 .   ? 10.466 -16.290 -4.823  1.00 36.97  ? 204 HOH A O   1 
HETATM 1599 O O   . HOH C 2 .   ? 18.808 -11.939 11.318  1.00 38.98  ? 205 HOH A O   1 
HETATM 1600 O O   . HOH C 2 .   ? 7.681  -13.109 6.252   1.00 52.06  ? 206 HOH A O   1 
HETATM 1601 O O   . HOH C 2 .   ? 8.380  -10.433 4.206   1.00 53.20  ? 207 HOH A O   1 
HETATM 1602 O O   . HOH C 2 .   ? 20.132 -9.091  -6.645  1.00 48.07  ? 208 HOH A O   1 
HETATM 1603 O O   . HOH C 2 .   ? 13.271 -18.922 -6.694  1.00 28.31  ? 209 HOH A O   1 
HETATM 1604 O O   . HOH C 2 .   ? 10.540 -25.621 -0.395  1.00 37.78  ? 210 HOH A O   1 
HETATM 1605 O O   . HOH C 2 .   ? 13.104 -11.644 10.629  1.00 36.56  ? 211 HOH A O   1 
HETATM 1606 O O   . HOH C 2 .   ? 20.830 -15.912 -11.579 1.00 36.73  ? 212 HOH A O   1 
HETATM 1607 O O   . HOH C 2 .   ? 14.583 -19.830 -9.174  1.00 47.72  ? 213 HOH A O   1 
HETATM 1608 O O   . HOH C 2 .   ? 27.812 -7.768  2.034   1.00 53.28  ? 214 HOH A O   1 
HETATM 1609 O O   . HOH C 2 .   ? 10.138 -19.249 -4.936  1.00 34.16  ? 215 HOH A O   1 
HETATM 1610 O O   . HOH C 2 .   ? 23.477 -6.251  12.938  1.00 47.35  ? 216 HOH A O   1 
HETATM 1611 O O   . HOH C 2 .   ? 9.212  -18.747 -0.733  1.00 48.05  ? 217 HOH A O   1 
HETATM 1612 O O   . HOH C 2 .   ? 28.408 -31.066 -0.973  1.00 51.79  ? 218 HOH A O   1 
HETATM 1613 O O   . HOH C 2 .   ? 23.952 -35.052 -0.579  1.00 75.72  ? 219 HOH A O   1 
HETATM 1614 O O   . HOH C 2 .   ? 13.624 -4.145  5.052   1.00 53.88  ? 220 HOH A O   1 
HETATM 1615 O O   . HOH C 2 .   ? 8.527  -21.485 0.159   1.00 50.58  ? 221 HOH A O   1 
HETATM 1616 O O   . HOH C 2 .   ? 12.298 -10.626 -5.666  1.00 52.38  ? 222 HOH A O   1 
HETATM 1617 O O   . HOH C 2 .   ? 12.464 -25.943 2.562   1.00 38.88  ? 223 HOH A O   1 
HETATM 1618 O O   . HOH C 2 .   ? 27.219 -10.710 3.415   1.00 42.03  ? 224 HOH A O   1 
HETATM 1619 O O   . HOH C 2 .   ? 11.008 -10.925 12.319  1.00 40.55  ? 225 HOH A O   1 
HETATM 1620 O O   . HOH C 2 .   ? 15.672 -32.459 -3.901  1.00 49.69  ? 226 HOH A O   1 
HETATM 1621 O O   . HOH C 2 .   ? 7.303  -13.517 3.273   1.00 58.04  ? 227 HOH A O   1 
HETATM 1622 O O   . HOH C 2 .   ? 7.800  -16.869 9.230   1.00 36.33  ? 228 HOH A O   1 
HETATM 1623 O O   . HOH C 2 .   ? 28.504 -11.322 -4.559  1.00 48.90  ? 229 HOH A O   1 
HETATM 1624 O O   . HOH C 2 .   ? 13.432 -28.461 3.881   1.00 59.93  ? 230 HOH A O   1 
HETATM 1625 O O   . HOH C 2 .   ? 31.925 -29.061 -6.385  1.00 62.03  ? 231 HOH A O   1 
HETATM 1626 O O   . HOH C 2 .   ? 15.942 -12.200 13.105  1.00 48.26  ? 232 HOH A O   1 
HETATM 1627 O O   . HOH C 2 .   ? 19.288 -26.580 -18.066 1.00 60.86  ? 233 HOH A O   1 
HETATM 1628 O O   . HOH C 2 .   ? 18.183 -23.902 8.956   1.00 56.84  ? 234 HOH A O   1 
HETATM 1629 O O   . HOH C 2 .   ? 8.102  -15.153 -0.884  1.00 47.46  ? 235 HOH A O   1 
HETATM 1630 O O   . HOH C 2 .   ? 15.343 -26.252 -15.062 1.00 52.55  ? 236 HOH A O   1 
HETATM 1631 O O   . HOH C 2 .   ? 33.601 -34.859 -4.815  1.00 49.37  ? 237 HOH A O   1 
HETATM 1632 O O   . HOH C 2 .   ? 14.941 -10.699 -6.965  1.00 47.67  ? 238 HOH A O   1 
HETATM 1633 O O   . HOH C 2 .   ? 28.629 -21.530 6.278   1.00 62.47  ? 239 HOH A O   1 
HETATM 1634 O O   . HOH C 2 .   ? 27.996 0.444   4.940   1.00 68.04  ? 240 HOH A O   1 
HETATM 1635 O O   . HOH C 2 .   ? 31.122 -18.372 -4.178  1.00 52.08  ? 241 HOH A O   1 
HETATM 1636 O O   . HOH C 2 .   ? 3.238  -7.847  4.828   1.00 57.02  ? 242 HOH A O   1 
HETATM 1637 O O   . HOH C 2 .   ? 17.230 -8.767  -6.805  1.00 65.04  ? 243 HOH A O   1 
HETATM 1638 O O   . HOH C 2 .   ? 7.036  -15.953 6.454   1.00 52.19  ? 244 HOH A O   1 
HETATM 1639 O O   . HOH C 2 .   ? 14.996 -21.772 -11.340 1.00 53.39  ? 245 HOH A O   1 
HETATM 1640 O O   . HOH C 2 .   ? 8.033  -25.264 3.899   1.00 80.73  ? 246 HOH A O   1 
HETATM 1641 O O   . HOH C 2 .   ? 25.105 -10.578 -7.745  1.00 57.91  ? 247 HOH A O   1 
HETATM 1642 O O   . HOH C 2 .   ? 22.566 -11.374 -9.011  1.00 52.40  ? 248 HOH A O   1 
HETATM 1643 O O   . HOH C 2 .   ? 10.031 -15.850 -8.021  1.00 49.22  ? 249 HOH A O   1 
HETATM 1644 O O   . HOH D 2 .   ? 23.333 0.027   -22.394 1.00 48.41  ? 201 HOH B O   1 
HETATM 1645 O O   . HOH D 2 .   ? 23.342 -22.292 -24.116 1.00 85.87  ? 202 HOH B O   1 
HETATM 1646 O O   . HOH D 2 .   ? 27.584 -0.395  -21.973 1.00 38.15  ? 203 HOH B O   1 
HETATM 1647 O O   . HOH D 2 .   ? 41.331 -9.209  -22.010 1.00 61.17  ? 204 HOH B O   1 
HETATM 1648 O O   . HOH D 2 .   ? 18.995 -3.674  -17.313 1.00 42.54  ? 205 HOH B O   1 
HETATM 1649 O O   . HOH D 2 .   ? 22.611 -13.779 -10.594 1.00 27.10  ? 206 HOH B O   1 
HETATM 1650 O O   . HOH D 2 .   ? 19.781 -23.421 -27.673 1.00 84.28  ? 207 HOH B O   1 
HETATM 1651 O O   . HOH D 2 .   ? 27.429 -22.477 -19.050 1.00 53.68  ? 208 HOH B O   1 
HETATM 1652 O O   . HOH D 2 .   ? 8.244  -16.443 -21.476 1.00 46.61  ? 209 HOH B O   1 
HETATM 1653 O O   . HOH D 2 .   ? 22.593 -5.345  -15.258 1.00 27.68  ? 210 HOH B O   1 
HETATM 1654 O O   . HOH D 2 .   ? 10.575 -11.978 -28.404 1.00 41.35  ? 211 HOH B O   1 
HETATM 1655 O O   . HOH D 2 .   ? 33.821 -7.853  -4.696  1.00 64.88  ? 212 HOH B O   1 
HETATM 1656 O O   . HOH D 2 .   ? 38.457 -19.501 -16.985 1.00 76.57  ? 213 HOH B O   1 
HETATM 1657 O O   . HOH D 2 .   ? 15.329 -7.881  -32.918 1.00 55.55  ? 214 HOH B O   1 
HETATM 1658 O O   . HOH D 2 .   ? 21.513 -2.247  -17.247 1.00 38.13  ? 215 HOH B O   1 
HETATM 1659 O O   . HOH D 2 .   ? 15.072 -22.055 -16.327 1.00 69.37  ? 216 HOH B O   1 
HETATM 1660 O O   . HOH D 2 .   ? 24.309 -6.106  -12.941 1.00 52.97  ? 217 HOH B O   1 
HETATM 1661 O O   . HOH D 2 .   ? 14.370 -11.994 -38.385 1.00 64.62  ? 218 HOH B O   1 
HETATM 1662 O O   . HOH D 2 .   ? 20.972 -1.580  -21.943 1.00 48.97  ? 219 HOH B O   1 
HETATM 1663 O O   . HOH D 2 .   ? 16.137 -23.147 -24.044 1.00 61.99  ? 220 HOH B O   1 
HETATM 1664 O O   . HOH D 2 .   ? 15.370 -9.705  -15.264 1.00 50.48  ? 221 HOH B O   1 
HETATM 1665 O O   . HOH D 2 .   ? 39.874 -3.051  -19.342 1.00 64.98  ? 222 HOH B O   1 
HETATM 1666 O O   . HOH D 2 .   ? 19.615 -21.257 -25.581 1.00 61.73  ? 223 HOH B O   1 
HETATM 1667 O O   . HOH D 2 .   ? 19.142 -21.974 -17.152 1.00 45.28  ? 224 HOH B O   1 
HETATM 1668 O O   . HOH D 2 .   ? 16.264 -2.515  -24.435 1.00 63.87  ? 225 HOH B O   1 
HETATM 1669 O O   . HOH D 2 .   ? 18.494 -1.892  -19.529 1.00 51.43  ? 226 HOH B O   1 
HETATM 1670 O O   . HOH D 2 .   ? 13.710 -19.512 -35.205 1.00 47.79  ? 227 HOH B O   1 
HETATM 1671 O O   . HOH D 2 .   ? 13.239 -6.223  -34.340 1.00 57.90  ? 228 HOH B O   1 
HETATM 1672 O O   . HOH D 2 .   ? 9.938  -6.391  -24.206 1.00 55.91  ? 229 HOH B O   1 
HETATM 1673 O O   . HOH D 2 .   ? 19.288 -16.693 -13.877 1.00 52.22  ? 230 HOH B O   1 
HETATM 1674 O O   . HOH D 2 .   ? 15.193 -14.823 -15.877 1.00 55.85  ? 231 HOH B O   1 
HETATM 1675 O O   . HOH D 2 .   ? 18.583 -19.498 -14.668 1.00 60.60  ? 232 HOH B O   1 
HETATM 1676 O O   . HOH D 2 .   ? 22.505 -11.968 -34.253 1.00 61.26  ? 233 HOH B O   1 
HETATM 1677 O O   . HOH D 2 .   ? 8.224  -0.119  -26.664 1.00 61.14  ? 234 HOH B O   1 
HETATM 1678 O O   . HOH D 2 .   ? 17.680 -3.436  -14.723 1.00 49.03  ? 235 HOH B O   1 
HETATM 1679 O O   . HOH D 2 .   ? 41.234 -12.949 -23.691 1.00 55.32  ? 236 HOH B O   1 
# 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   1   ALA ALA A . n 
A 1 2   PRO 2   2   2   PRO PRO A . n 
A 1 3   VAL 3   3   3   VAL VAL A . n 
A 1 4   GLN 4   4   4   GLN GLN A . n 
A 1 5   GLY 5   5   5   GLY GLY A . n 
A 1 6   ILE 6   6   6   ILE ILE A . n 
A 1 7   ILE 7   7   7   ILE ILE A . n 
A 1 8   ASN 8   8   8   ASN ASN A . n 
A 1 9   PHE 9   9   9   PHE PHE A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  GLN 11  11  11  GLN GLN A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  GLU 13  13  13  GLU GLU A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  ASN 15  15  15  ASN ASN A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  PRO 17  17  17  PRO PRO A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  LYS 19  19  19  LYS LYS A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  TRP 21  21  21  TRP TRP A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  ILE 24  24  24  ILE ILE A . n 
A 1 25  LYS 25  25  25  LYS LYS A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  THR 28  28  28  THR THR A . n 
A 1 29  GLU 29  29  29  GLU GLU A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  HIS 32  32  32  HIS HIS A . n 
A 1 33  GLY 33  33  33  GLY GLY A . n 
A 1 34  PHE 34  34  34  PHE PHE A . n 
A 1 35  HIS 35  35  35  HIS HIS A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  HIS 37  37  37  HIS HIS A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  GLY 40  40  40  GLY GLY A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  ASP 42  42  42  ASP ASP A . n 
A 1 43  LEU 43  43  43  LEU LEU A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  ASN 45  45  45  ASN ASN A . n 
A 1 46  VAL 46  46  46  VAL VAL A . n 
A 1 47  THR 47  47  47  THR THR A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  ASP 49  49  49  ASP ASP A . n 
A 1 50  LYS 50  50  50  LYS LYS A . n 
A 1 51  ASP 51  51  51  ASP ASP A . n 
A 1 52  GLY 52  52  52  GLY GLY A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  ALA 54  54  54  ALA ALA A . n 
A 1 55  ASP 55  55  55  ASP ASP A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  SER 57  57  57  SER SER A . n 
A 1 58  ILE 58  58  58  ILE ILE A . n 
A 1 59  GLU 59  59  59  GLU GLU A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  VAL 62  62  62  VAL VAL A . n 
A 1 63  ILE 63  63  63  ILE ILE A . n 
A 1 64  SER 64  64  64  SER SER A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  SER 66  66  66  SER SER A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  ASP 68  68  68  ASP ASP A . n 
A 1 69  HIS 69  69  69  HIS HIS A . n 
A 1 70  SER 70  70  70  SER SER A . n 
A 1 71  ILE 71  71  71  ILE ILE A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  ARG 74  74  74  ARG ARG A . n 
A 1 75  THR 75  75  75  THR THR A . n 
A 1 76  LEU 76  76  76  LEU LEU A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  VAL 78  78  78  VAL VAL A . n 
A 1 79  HIS 79  79  79  HIS HIS A . n 
A 1 80  GLU 80  80  80  GLU GLU A . n 
A 1 81  LYS 81  81  81  LYS LYS A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  GLY 83  83  83  GLY GLY A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  ALA 86  86  86  ALA ALA A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  SER 88  88  88  SER SER A . n 
A 1 89  ARG 89  89  89  ARG ARG A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  ALA 91  91  91  ALA ALA A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  GLY 93  93  93  GLY GLY A . n 
A 1 94  VAL 94  94  94  VAL VAL A . n 
A 1 95  ILE 95  95  95  ILE ILE A . n 
A 1 96  GLY 96  96  96  GLY GLY A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  GLN 99  99  99  GLN GLN A . n 
A 1 100 ALA 100 100 100 ALA ALA A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 THR 105 105 105 THR THR A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 ALA 107 107 107 ALA ALA A . n 
A 1 108 VAL 108 108 108 VAL VAL A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 LYS 112 112 112 LYS LYS A . n 
A 1 113 GLY 113 113 113 GLY GLY A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 GLY 115 115 115 GLY GLY A . n 
B 1 1   ALA 1   1   1   ALA ALA B . n 
B 1 2   PRO 2   2   2   PRO PRO B . n 
B 1 3   VAL 3   3   3   VAL VAL B . n 
B 1 4   GLN 4   4   4   GLN GLN B . n 
B 1 5   GLY 5   5   5   GLY GLY B . n 
B 1 6   ILE 6   6   6   ILE ILE B . n 
B 1 7   ILE 7   7   7   ILE ILE B . n 
B 1 8   ASN 8   8   8   ASN ASN B . n 
B 1 9   PHE 9   9   9   PHE PHE B . n 
B 1 10  GLU 10  10  10  GLU GLU B . n 
B 1 11  GLN 11  11  11  GLN GLN B . n 
B 1 12  LYS 12  12  12  LYS LYS B . n 
B 1 13  GLU 13  13  13  GLU GLU B . n 
B 1 14  SER 14  14  14  SER SER B . n 
B 1 15  ASN 15  15  15  ASN ASN B . n 
B 1 16  GLY 16  16  16  GLY GLY B . n 
B 1 17  PRO 17  17  17  PRO PRO B . n 
B 1 18  VAL 18  18  18  VAL VAL B . n 
B 1 19  LYS 19  19  19  LYS LYS B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  TRP 21  21  21  TRP TRP B . n 
B 1 22  GLY 22  22  22  GLY GLY B . n 
B 1 23  SER 23  23  23  SER SER B . n 
B 1 24  ILE 24  24  24  ILE ILE B . n 
B 1 25  LYS 25  25  25  LYS LYS B . n 
B 1 26  GLY 26  26  26  GLY GLY B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  THR 28  28  28  THR THR B . n 
B 1 29  GLU 29  29  29  GLU GLU B . n 
B 1 30  GLY 30  30  30  GLY GLY B . n 
B 1 31  LEU 31  31  31  LEU LEU B . n 
B 1 32  HIS 32  32  32  HIS HIS B . n 
B 1 33  GLY 33  33  33  GLY GLY B . n 
B 1 34  PHE 34  34  34  PHE PHE B . n 
B 1 35  HIS 35  35  35  HIS HIS B . n 
B 1 36  VAL 36  36  36  VAL VAL B . n 
B 1 37  HIS 37  37  37  HIS HIS B . n 
B 1 38  GLY 38  38  38  GLY GLY B . n 
B 1 39  ALA 39  39  39  ALA ALA B . n 
B 1 40  GLY 40  40  40  GLY GLY B . n 
B 1 41  GLY 41  41  41  GLY GLY B . n 
B 1 42  ASP 42  42  42  ASP ASP B . n 
B 1 43  LEU 43  43  43  LEU LEU B . n 
B 1 44  GLY 44  44  44  GLY GLY B . n 
B 1 45  ASN 45  45  45  ASN ASN B . n 
B 1 46  VAL 46  46  46  VAL VAL B . n 
B 1 47  THR 47  47  47  THR THR B . n 
B 1 48  ALA 48  48  48  ALA ALA B . n 
B 1 49  ASP 49  49  49  ASP ASP B . n 
B 1 50  LYS 50  50  50  LYS LYS B . n 
B 1 51  ASP 51  51  51  ASP ASP B . n 
B 1 52  GLY 52  52  52  GLY GLY B . n 
B 1 53  VAL 53  53  53  VAL VAL B . n 
B 1 54  ALA 54  54  54  ALA ALA B . n 
B 1 55  ASP 55  55  55  ASP ASP B . n 
B 1 56  VAL 56  56  56  VAL VAL B . n 
B 1 57  SER 57  57  57  SER SER B . n 
B 1 58  ILE 58  58  58  ILE ILE B . n 
B 1 59  GLU 59  59  59  GLU GLU B . n 
B 1 60  ASP 60  60  60  ASP ASP B . n 
B 1 61  SER 61  61  61  SER SER B . n 
B 1 62  VAL 62  62  62  VAL VAL B . n 
B 1 63  ILE 63  63  63  ILE ILE B . n 
B 1 64  SER 64  64  64  SER SER B . n 
B 1 65  LEU 65  65  65  LEU LEU B . n 
B 1 66  SER 66  66  66  SER SER B . n 
B 1 67  GLY 67  67  67  GLY GLY B . n 
B 1 68  ASP 68  68  68  ASP ASP B . n 
B 1 69  HIS 69  69  69  HIS HIS B . n 
B 1 70  SER 70  70  70  SER SER B . n 
B 1 71  ILE 71  71  71  ILE ILE B . n 
B 1 72  ILE 72  72  72  ILE ILE B . n 
B 1 73  GLY 73  73  73  GLY GLY B . n 
B 1 74  ARG 74  74  74  ARG ARG B . n 
B 1 75  THR 75  75  75  THR THR B . n 
B 1 76  LEU 76  76  76  LEU LEU B . n 
B 1 77  VAL 77  77  77  VAL VAL B . n 
B 1 78  VAL 78  78  78  VAL VAL B . n 
B 1 79  HIS 79  79  79  HIS HIS B . n 
B 1 80  GLU 80  80  80  GLU GLU B . n 
B 1 81  LYS 81  81  81  LYS LYS B . n 
B 1 82  ALA 82  82  82  ALA ALA B . n 
B 1 83  GLY 83  83  83  GLY GLY B . n 
B 1 84  ALA 84  84  84  ALA ALA B . n 
B 1 85  GLY 85  85  85  GLY GLY B . n 
B 1 86  ALA 86  86  86  ALA ALA B . n 
B 1 87  GLY 87  87  87  GLY GLY B . n 
B 1 88  SER 88  88  88  SER SER B . n 
B 1 89  ARG 89  89  89  ARG ARG B . n 
B 1 90  LEU 90  90  90  LEU LEU B . n 
B 1 91  ALA 91  91  91  ALA ALA B . n 
B 1 92  SER 92  92  92  SER SER B . n 
B 1 93  GLY 93  93  93  GLY GLY B . n 
B 1 94  VAL 94  94  94  VAL VAL B . n 
B 1 95  ILE 95  95  95  ILE ILE B . n 
B 1 96  GLY 96  96  96  GLY GLY B . n 
B 1 97  ILE 97  97  97  ILE ILE B . n 
B 1 98  ALA 98  98  98  ALA ALA B . n 
B 1 99  GLN 99  99  99  GLN GLN B . n 
B 1 100 ALA 100 100 100 ALA ALA B . n 
B 1 101 GLY 101 101 101 GLY GLY B . n 
B 1 102 ALA 102 102 102 ALA ALA B . n 
B 1 103 GLY 103 103 103 GLY ALA B . n 
B 1 104 ALA 104 104 104 ALA ALA B . n 
B 1 105 THR 105 105 105 THR THR B . n 
B 1 106 LYS 106 106 106 LYS LYS B . n 
B 1 107 ALA 107 107 107 ALA ALA B . n 
B 1 108 VAL 108 108 108 VAL VAL B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 VAL 110 110 110 VAL VAL B . n 
B 1 111 LEU 111 111 111 LEU LEU B . n 
B 1 112 LYS 112 112 112 LYS LYS B . n 
B 1 113 GLY 113 113 113 GLY GLY B . n 
B 1 114 ASP 114 114 114 ASP ASP B . n 
B 1 115 GLY 115 115 115 GLY GLY B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 HOH 1  201 38 HOH HOH A . 
C 2 HOH 2  202 9  HOH HOH A . 
C 2 HOH 3  203 32 HOH HOH A . 
C 2 HOH 4  204 16 HOH HOH A . 
C 2 HOH 5  205 12 HOH HOH A . 
C 2 HOH 6  206 85 HOH HOH A . 
C 2 HOH 7  207 72 HOH HOH A . 
C 2 HOH 8  208 69 HOH HOH A . 
C 2 HOH 9  209 2  HOH HOH A . 
C 2 HOH 10 210 31 HOH HOH A . 
C 2 HOH 11 211 10 HOH HOH A . 
C 2 HOH 12 212 5  HOH HOH A . 
C 2 HOH 13 213 73 HOH HOH A . 
C 2 HOH 14 214 62 HOH HOH A . 
C 2 HOH 15 215 8  HOH HOH A . 
C 2 HOH 16 216 29 HOH HOH A . 
C 2 HOH 17 217 35 HOH HOH A . 
C 2 HOH 18 218 81 HOH HOH A . 
C 2 HOH 19 219 66 HOH HOH A . 
C 2 HOH 20 220 55 HOH HOH A . 
C 2 HOH 21 221 87 HOH HOH A . 
C 2 HOH 22 222 39 HOH HOH A . 
C 2 HOH 23 223 15 HOH HOH A . 
C 2 HOH 24 224 4  HOH HOH A . 
C 2 HOH 25 225 1  HOH HOH A . 
C 2 HOH 26 226 91 HOH HOH A . 
C 2 HOH 27 227 86 HOH HOH A . 
C 2 HOH 28 228 13 HOH HOH A . 
C 2 HOH 29 229 27 HOH HOH A . 
C 2 HOH 30 230 61 HOH HOH A . 
C 2 HOH 31 231 83 HOH HOH A . 
C 2 HOH 32 232 64 HOH HOH A . 
C 2 HOH 33 233 46 HOH HOH A . 
C 2 HOH 34 234 20 HOH HOH A . 
C 2 HOH 35 235 68 HOH HOH A . 
C 2 HOH 36 236 24 HOH HOH A . 
C 2 HOH 37 237 37 HOH HOH A . 
C 2 HOH 38 238 6  HOH HOH A . 
C 2 HOH 39 239 65 HOH HOH A . 
C 2 HOH 40 240 59 HOH HOH A . 
C 2 HOH 41 241 71 HOH HOH A . 
C 2 HOH 42 242 74 HOH HOH A . 
C 2 HOH 43 243 89 HOH HOH A . 
C 2 HOH 44 244 50 HOH HOH A . 
C 2 HOH 45 245 79 HOH HOH A . 
C 2 HOH 46 246 51 HOH HOH A . 
C 2 HOH 47 247 45 HOH HOH A . 
C 2 HOH 48 248 47 HOH HOH A . 
C 2 HOH 49 249 41 HOH HOH A . 
D 2 HOH 1  201 14 HOH HOH B . 
D 2 HOH 2  202 63 HOH HOH B . 
D 2 HOH 3  203 49 HOH HOH B . 
D 2 HOH 4  204 80 HOH HOH B . 
D 2 HOH 5  205 7  HOH HOH B . 
D 2 HOH 6  206 3  HOH HOH B . 
D 2 HOH 7  207 77 HOH HOH B . 
D 2 HOH 8  208 75 HOH HOH B . 
D 2 HOH 9  209 84 HOH HOH B . 
D 2 HOH 10 210 11 HOH HOH B . 
D 2 HOH 11 211 25 HOH HOH B . 
D 2 HOH 12 212 82 HOH HOH B . 
D 2 HOH 13 213 67 HOH HOH B . 
D 2 HOH 14 214 30 HOH HOH B . 
D 2 HOH 15 215 28 HOH HOH B . 
D 2 HOH 16 216 34 HOH HOH B . 
D 2 HOH 17 217 53 HOH HOH B . 
D 2 HOH 18 218 88 HOH HOH B . 
D 2 HOH 19 219 52 HOH HOH B . 
D 2 HOH 20 220 48 HOH HOH B . 
D 2 HOH 21 221 26 HOH HOH B . 
D 2 HOH 22 222 42 HOH HOH B . 
D 2 HOH 23 223 18 HOH HOH B . 
D 2 HOH 24 224 56 HOH HOH B . 
D 2 HOH 25 225 19 HOH HOH B . 
D 2 HOH 26 226 90 HOH HOH B . 
D 2 HOH 27 227 57 HOH HOH B . 
D 2 HOH 28 228 23 HOH HOH B . 
D 2 HOH 29 229 76 HOH HOH B . 
D 2 HOH 30 230 21 HOH HOH B . 
D 2 HOH 31 231 58 HOH HOH B . 
D 2 HOH 32 232 70 HOH HOH B . 
D 2 HOH 33 233 43 HOH HOH B . 
D 2 HOH 34 234 54 HOH HOH B . 
D 2 HOH 35 235 92 HOH HOH B . 
D 2 HOH 36 236 78 HOH HOH B . 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C 
2 1 B,D 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2017-02-01 
2 'Structure model' 1 1 2018-01-17 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Data collection' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            diffrn_source 
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    2 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_diffrn_source.pdbx_synchrotron_site' 
# 
loop_
_pdbx_refine_tls.pdbx_refine_id 
_pdbx_refine_tls.id 
_pdbx_refine_tls.details 
_pdbx_refine_tls.method 
_pdbx_refine_tls.origin_x 
_pdbx_refine_tls.origin_y 
_pdbx_refine_tls.origin_z 
_pdbx_refine_tls.T[1][1] 
_pdbx_refine_tls.T[2][2] 
_pdbx_refine_tls.T[3][3] 
_pdbx_refine_tls.T[1][2] 
_pdbx_refine_tls.T[1][3] 
_pdbx_refine_tls.T[2][3] 
_pdbx_refine_tls.L[1][1] 
_pdbx_refine_tls.L[2][2] 
_pdbx_refine_tls.L[3][3] 
_pdbx_refine_tls.L[1][2] 
_pdbx_refine_tls.L[1][3] 
_pdbx_refine_tls.L[2][3] 
_pdbx_refine_tls.S[1][1] 
_pdbx_refine_tls.S[2][2] 
_pdbx_refine_tls.S[3][3] 
_pdbx_refine_tls.S[1][2] 
_pdbx_refine_tls.S[1][3] 
_pdbx_refine_tls.S[2][3] 
_pdbx_refine_tls.S[2][1] 
_pdbx_refine_tls.S[3][1] 
_pdbx_refine_tls.S[3][2] 
'X-RAY DIFFRACTION' 1 ? refined 20.6882 -18.2236 -0.1497  0.0634 0.0362 0.1485 0.0039  -0.0055 0.0077  0.1297 0.1762 0.1055 
-0.0288 -0.0658 0.0813  0.0203  -0.0201 -0.0001 -0.0301 -0.0115 -0.0228 -0.0426 0.0219 0.0004  
'X-RAY DIFFRACTION' 2 ? refined 24.2713 -12.6403 -22.2038 0.0523 0.0520 0.1613 -0.0026 0.0108  -0.0129 0.5686 0.5358 0.1174 0.3770 
-0.1451 -0.2458 -0.0807 0.0427  0.0380  0.0211  -0.0923 -0.0608 -0.0710 0.0228 -0.0139 
# 
loop_
_pdbx_refine_tls_group.pdbx_refine_id 
_pdbx_refine_tls_group.id 
_pdbx_refine_tls_group.refine_tls_id 
_pdbx_refine_tls_group.beg_auth_asym_id 
_pdbx_refine_tls_group.beg_auth_seq_id 
_pdbx_refine_tls_group.end_auth_asym_id 
_pdbx_refine_tls_group.end_auth_seq_id 
_pdbx_refine_tls_group.selection_details 
_pdbx_refine_tls_group.beg_label_asym_id 
_pdbx_refine_tls_group.beg_label_seq_id 
_pdbx_refine_tls_group.end_label_asym_id 
_pdbx_refine_tls_group.end_label_seq_id 
_pdbx_refine_tls_group.selection 
'X-RAY DIFFRACTION' 1 1 A 1 A 115 ? ? ? ? ? ? 
'X-RAY DIFFRACTION' 2 2 B 1 B 115 ? ? ? ? ? ? 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .        1 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC      ? ? ? 5.7.0032 2 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? 3.20     3 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? iMOSFLM     ? ? ? .        4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? MOLREP      ? ? ? .        5 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA B 39  ? ? -59.49  109.36 
2 1 SER B 57  ? ? -157.81 74.02  
3 1 ASP B 114 ? ? -142.46 -61.75 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
