data_4LYG
# 
_entry.id   4LYG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.281 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB   4LYG         
RCSB  RCSB081243   
WWPDB D_1000081243 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.db_id 
_pdbx_database_related.details 
_pdbx_database_related.content_type 
PDB 3S5J . unspecified 
PDB 4LZN . unspecified 
PDB 4LZO . unspecified 
PDB 4M0P . unspecified 
PDB 4M0U . unspecified 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.entry_id                        4LYG 
_pdbx_database_status.recvd_initial_deposition_date   2013-07-31 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.methods_development_category    CASP 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
'Chen, P.' 1 
'Teng, M.' 2 
'Li, X.'   3 
# 
_citation.id                        primary 
_citation.title                     
;Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
;
_citation.journal_abbrev            'Plos One' 
_citation.journal_volume            10 
_citation.page_first                e0120304 
_citation.page_last                 e0120304 
_citation.year                      2015 
_citation.journal_id_ASTM           ? 
_citation.country                   US 
_citation.journal_id_ISSN           1932-6203 
_citation.journal_id_CSD            ? 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   25781187 
_citation.pdbx_database_id_DOI      10.1371/journal.pone.0120304 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
primary 'Chen, P.'  1  
primary 'Liu, Z.'   2  
primary 'Wang, X.'  3  
primary 'Peng, J.'  4  
primary 'Sun, Q.'   5  
primary 'Li, J.'    6  
primary 'Wang, M.'  7  
primary 'Niu, L.'   8  
primary 'Zhang, Z.' 9  
primary 'Cai, G.'   10 
primary 'Teng, M.'  11 
primary 'Li, X.'    12 
# 
_cell.entry_id           4LYG 
_cell.length_a           169.498 
_cell.length_b           169.498 
_cell.length_c           61.871 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        120.00 
_cell.Z_PDB              18 
_cell.pdbx_unique_axis   ? 
_cell.length_a_esd       ? 
_cell.length_b_esd       ? 
_cell.length_c_esd       ? 
_cell.angle_alpha_esd    ? 
_cell.angle_beta_esd     ? 
_cell.angle_gamma_esd    ? 
# 
_symmetry.entry_id                         4LYG 
_symmetry.space_group_name_H-M             'H 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                146 
_symmetry.space_group_name_Hall            ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Ribose-phosphate pyrophosphokinase 1' 35922.363 2 2.7.6.1 E43T ? ? 
2 non-polymer syn 'SULFATE ION'                          96.063    5 ?       ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'PPRibP, Phosphoribosyl pyrophosphate synthase I, PRS-I' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVTIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA
SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPLLE
HHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVTIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA
SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPLLE
HHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   PRO n 
1 3   ASN n 
1 4   ILE n 
1 5   LYS n 
1 6   ILE n 
1 7   PHE n 
1 8   SER n 
1 9   GLY n 
1 10  SER n 
1 11  SER n 
1 12  HIS n 
1 13  GLN n 
1 14  ASP n 
1 15  LEU n 
1 16  SER n 
1 17  GLN n 
1 18  LYS n 
1 19  ILE n 
1 20  ALA n 
1 21  ASP n 
1 22  ARG n 
1 23  LEU n 
1 24  GLY n 
1 25  LEU n 
1 26  GLU n 
1 27  LEU n 
1 28  GLY n 
1 29  LYS n 
1 30  VAL n 
1 31  VAL n 
1 32  THR n 
1 33  LYS n 
1 34  LYS n 
1 35  PHE n 
1 36  SER n 
1 37  ASN n 
1 38  GLN n 
1 39  GLU n 
1 40  THR n 
1 41  CYS n 
1 42  VAL n 
1 43  THR n 
1 44  ILE n 
1 45  GLY n 
1 46  GLU n 
1 47  SER n 
1 48  VAL n 
1 49  ARG n 
1 50  GLY n 
1 51  GLU n 
1 52  ASP n 
1 53  VAL n 
1 54  TYR n 
1 55  ILE n 
1 56  VAL n 
1 57  GLN n 
1 58  SER n 
1 59  GLY n 
1 60  CYS n 
1 61  GLY n 
1 62  GLU n 
1 63  ILE n 
1 64  ASN n 
1 65  ASP n 
1 66  ASN n 
1 67  LEU n 
1 68  MET n 
1 69  GLU n 
1 70  LEU n 
1 71  LEU n 
1 72  ILE n 
1 73  MET n 
1 74  ILE n 
1 75  ASN n 
1 76  ALA n 
1 77  CYS n 
1 78  LYS n 
1 79  ILE n 
1 80  ALA n 
1 81  SER n 
1 82  ALA n 
1 83  SER n 
1 84  ARG n 
1 85  VAL n 
1 86  THR n 
1 87  ALA n 
1 88  VAL n 
1 89  ILE n 
1 90  PRO n 
1 91  CYS n 
1 92  PHE n 
1 93  PRO n 
1 94  TYR n 
1 95  ALA n 
1 96  ARG n 
1 97  GLN n 
1 98  ASP n 
1 99  LYS n 
1 100 LYS n 
1 101 ASP n 
1 102 LYS n 
1 103 SER n 
1 104 ARG n 
1 105 ALA n 
1 106 PRO n 
1 107 ILE n 
1 108 SER n 
1 109 ALA n 
1 110 LYS n 
1 111 LEU n 
1 112 VAL n 
1 113 ALA n 
1 114 ASN n 
1 115 MET n 
1 116 LEU n 
1 117 SER n 
1 118 VAL n 
1 119 ALA n 
1 120 GLY n 
1 121 ALA n 
1 122 ASP n 
1 123 HIS n 
1 124 ILE n 
1 125 ILE n 
1 126 THR n 
1 127 MET n 
1 128 ASP n 
1 129 LEU n 
1 130 HIS n 
1 131 ALA n 
1 132 SER n 
1 133 GLN n 
1 134 ILE n 
1 135 GLN n 
1 136 GLY n 
1 137 PHE n 
1 138 PHE n 
1 139 ASP n 
1 140 ILE n 
1 141 PRO n 
1 142 VAL n 
1 143 ASP n 
1 144 ASN n 
1 145 LEU n 
1 146 TYR n 
1 147 ALA n 
1 148 GLU n 
1 149 PRO n 
1 150 ALA n 
1 151 VAL n 
1 152 LEU n 
1 153 LYS n 
1 154 TRP n 
1 155 ILE n 
1 156 ARG n 
1 157 GLU n 
1 158 ASN n 
1 159 ILE n 
1 160 SER n 
1 161 GLU n 
1 162 TRP n 
1 163 ARG n 
1 164 ASN n 
1 165 CYS n 
1 166 THR n 
1 167 ILE n 
1 168 VAL n 
1 169 SER n 
1 170 PRO n 
1 171 ASP n 
1 172 ALA n 
1 173 GLY n 
1 174 GLY n 
1 175 ALA n 
1 176 LYS n 
1 177 ARG n 
1 178 VAL n 
1 179 THR n 
1 180 SER n 
1 181 ILE n 
1 182 ALA n 
1 183 ASP n 
1 184 ARG n 
1 185 LEU n 
1 186 ASN n 
1 187 VAL n 
1 188 ASP n 
1 189 PHE n 
1 190 ALA n 
1 191 LEU n 
1 192 ILE n 
1 193 HIS n 
1 194 LYS n 
1 195 GLU n 
1 196 ARG n 
1 197 LYS n 
1 198 LYS n 
1 199 ALA n 
1 200 ASN n 
1 201 GLU n 
1 202 VAL n 
1 203 ASP n 
1 204 ARG n 
1 205 MET n 
1 206 VAL n 
1 207 LEU n 
1 208 VAL n 
1 209 GLY n 
1 210 ASP n 
1 211 VAL n 
1 212 LYS n 
1 213 ASP n 
1 214 ARG n 
1 215 VAL n 
1 216 ALA n 
1 217 ILE n 
1 218 LEU n 
1 219 VAL n 
1 220 ASP n 
1 221 ASP n 
1 222 MET n 
1 223 ALA n 
1 224 ASP n 
1 225 THR n 
1 226 CYS n 
1 227 GLY n 
1 228 THR n 
1 229 ILE n 
1 230 CYS n 
1 231 HIS n 
1 232 ALA n 
1 233 ALA n 
1 234 ASP n 
1 235 LYS n 
1 236 LEU n 
1 237 LEU n 
1 238 SER n 
1 239 ALA n 
1 240 GLY n 
1 241 ALA n 
1 242 THR n 
1 243 ARG n 
1 244 VAL n 
1 245 TYR n 
1 246 ALA n 
1 247 ILE n 
1 248 LEU n 
1 249 THR n 
1 250 HIS n 
1 251 GLY n 
1 252 ILE n 
1 253 PHE n 
1 254 SER n 
1 255 GLY n 
1 256 PRO n 
1 257 ALA n 
1 258 ILE n 
1 259 SER n 
1 260 ARG n 
1 261 ILE n 
1 262 ASN n 
1 263 ASN n 
1 264 ALA n 
1 265 CYS n 
1 266 PHE n 
1 267 GLU n 
1 268 ALA n 
1 269 VAL n 
1 270 VAL n 
1 271 VAL n 
1 272 THR n 
1 273 ASN n 
1 274 THR n 
1 275 ILE n 
1 276 PRO n 
1 277 GLN n 
1 278 GLU n 
1 279 ASP n 
1 280 LYS n 
1 281 MET n 
1 282 LYS n 
1 283 HIS n 
1 284 CYS n 
1 285 SER n 
1 286 LYS n 
1 287 ILE n 
1 288 GLN n 
1 289 VAL n 
1 290 ILE n 
1 291 ASP n 
1 292 ILE n 
1 293 SER n 
1 294 MET n 
1 295 ILE n 
1 296 LEU n 
1 297 ALA n 
1 298 GLU n 
1 299 ALA n 
1 300 ILE n 
1 301 ARG n 
1 302 ARG n 
1 303 THR n 
1 304 HIS n 
1 305 ASN n 
1 306 GLY n 
1 307 GLU n 
1 308 SER n 
1 309 VAL n 
1 310 SER n 
1 311 TYR n 
1 312 LEU n 
1 313 PHE n 
1 314 SER n 
1 315 HIS n 
1 316 VAL n 
1 317 PRO n 
1 318 LEU n 
1 319 LEU n 
1 320 GLU n 
1 321 HIS n 
1 322 HIS n 
1 323 HIS n 
1 324 HIS n 
1 325 HIS n 
1 326 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      ? 
_entity_src_gen.pdbx_beg_seq_num                   ? 
_entity_src_gen.pdbx_end_seq_num                   ? 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PRPS1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PRPS1_HUMAN 
_struct_ref.pdbx_db_accession          P60891 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIA
SASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
;
_struct_ref.pdbx_align_begin           1 
_struct_ref.pdbx_db_isoform            ? 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 4LYG A 1 ? 318 ? P60891 1 ? 318 ? 1 318 
2 1 4LYG B 1 ? 318 ? P60891 1 ? 318 ? 1 318 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 4LYG THR A 43  ? UNP P60891 GLU 43 'ENGINEERED MUTATION' 43  1  
1 4LYG LEU A 319 ? UNP P60891 ?   ?  'EXPRESSION TAG'      319 2  
1 4LYG GLU A 320 ? UNP P60891 ?   ?  'EXPRESSION TAG'      320 3  
1 4LYG HIS A 321 ? UNP P60891 ?   ?  'EXPRESSION TAG'      321 4  
1 4LYG HIS A 322 ? UNP P60891 ?   ?  'EXPRESSION TAG'      322 5  
1 4LYG HIS A 323 ? UNP P60891 ?   ?  'EXPRESSION TAG'      323 6  
1 4LYG HIS A 324 ? UNP P60891 ?   ?  'EXPRESSION TAG'      324 7  
1 4LYG HIS A 325 ? UNP P60891 ?   ?  'EXPRESSION TAG'      325 8  
1 4LYG HIS A 326 ? UNP P60891 ?   ?  'EXPRESSION TAG'      326 9  
2 4LYG THR B 43  ? UNP P60891 GLU 43 'ENGINEERED MUTATION' 43  10 
2 4LYG LEU B 319 ? UNP P60891 ?   ?  'EXPRESSION TAG'      319 11 
2 4LYG GLU B 320 ? UNP P60891 ?   ?  'EXPRESSION TAG'      320 12 
2 4LYG HIS B 321 ? UNP P60891 ?   ?  'EXPRESSION TAG'      321 13 
2 4LYG HIS B 322 ? UNP P60891 ?   ?  'EXPRESSION TAG'      322 14 
2 4LYG HIS B 323 ? UNP P60891 ?   ?  'EXPRESSION TAG'      323 15 
2 4LYG HIS B 324 ? UNP P60891 ?   ?  'EXPRESSION TAG'      324 16 
2 4LYG HIS B 325 ? UNP P60891 ?   ?  'EXPRESSION TAG'      325 17 
2 4LYG HIS B 326 ? UNP P60891 ?   ?  'EXPRESSION TAG'      326 18 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION'   ? 'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
_exptl.entry_id          4LYG 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.38 
_exptl_crystal.density_percent_sol   48.33 
_exptl_crystal.description           ? 
_exptl_crystal.F_000                 ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.temp            295 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pH              4.1 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.pdbx_details    'pH 4.1, VAPOR DIFFUSION, temperature 295K' 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.ambient_temp_details   ? 
_diffrn.crystal_id             1 
# 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.detector               CCD 
_diffrn_detector.type                   'ADSC QUANTUM 315r' 
_diffrn_detector.pdbx_collection_date   ? 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'SSRF BEAMLINE BL17U' 
_diffrn_source.pdbx_synchrotron_site       SSRF 
_diffrn_source.pdbx_synchrotron_beamline   BL17U 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_wavelength_list        1.0 
# 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.entry_id                     4LYG 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.d_resolution_low             48.93 
_reflns.d_resolution_high            3.0 
_reflns.number_obs                   13076 
_reflns.number_all                   13109 
_reflns.percent_possible_obs         ? 
_reflns.pdbx_Rmerge_I_obs            ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.pdbx_netI_over_sigmaI        ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_redundancy              ? 
_reflns.R_free_details               ? 
_reflns.limit_h_max                  ? 
_reflns.limit_h_min                  ? 
_reflns.limit_k_max                  ? 
_reflns.limit_k_min                  ? 
_reflns.limit_l_max                  ? 
_reflns.limit_l_min                  ? 
_reflns.observed_criterion_F_max     ? 
_reflns.observed_criterion_F_min     ? 
_reflns.pdbx_chi_squared             ? 
_reflns.pdbx_scaling_rejects         ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 4LYG 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     12462 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          . 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             48.93 
_refine.ls_d_res_high                            3.00 
_refine.ls_percent_reflns_obs                    98.33 
_refine.ls_R_factor_obs                          0.25545 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.25326 
_refine.ls_R_factor_R_free                       0.29765 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_number_reflns_R_free                  646 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.858 
_refine.correlation_coeff_Fo_to_Fc_free          0.809 
_refine.B_iso_mean                               41.139 
_refine.aniso_B[1][1]                            12.53 
_refine.aniso_B[2][2]                            12.53 
_refine.aniso_B[3][3]                            -25.06 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.40 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.119 
_refine.overall_SU_ML                            0.607 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             34.271 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.B_iso_min                                ? 
_refine.B_iso_max                                ? 
_refine.overall_SU_R_free                        ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        4694 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         25 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               4719 
_refine_hist.d_res_high                       3.00 
_refine_hist.d_res_low                        48.93 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.011  0.022  ? 4786 'X-RAY DIFFRACTION' ? 
r_bond_other_d               ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.281  1.960  ? 6474 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       5.655  5.000  ? 610  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       37.989 24.394 ? 198  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.710 15.000 ? 860  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       14.359 15.000 ? 31   'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.083  0.200  ? 767  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.005  0.021  ? 3483 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_mcbond_it                  0.508  1.500  ? 3049 'X-RAY DIFFRACTION' ? 
r_mcbond_other               ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_mcangle_it                 0.962  2.000  ? 4934 'X-RAY DIFFRACTION' ? 
r_mcangle_other              ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_scbond_it                  1.229  3.000  ? 1737 'X-RAY DIFFRACTION' ? 
r_scbond_other               ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_scangle_it                 2.138  4.500  ? 1540 'X-RAY DIFFRACTION' ? 
r_scangle_other              ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_long_range_B_other         ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           0.735  3.000  ? 4782 'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       2.995 
_refine_ls_shell.d_res_low                        3.073 
_refine_ls_shell.number_reflns_R_work             860 
_refine_ls_shell.R_factor_R_work                  0.240 
_refine_ls_shell.percent_reflns_obs               94.93 
_refine_ls_shell.R_factor_R_free                  0.308 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             58 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  4LYG 
_struct.title                     'Crystal structure of human PRS1 E43T mutant' 
_struct.pdbx_descriptor           'Ribose-phosphate pyrophosphokinase 1 (E.C.2.7.6.1)' 
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        4LYG 
_struct_keywords.pdbx_keywords   TRANSFERASE 
_struct_keywords.text            'PRS1, ATP R5P, TRANSFERASE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
# 
_struct_biol.id        1 
_struct_biol.details   ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  1  GLN A 13  ? LEU A 23  ? GLN A 13  LEU A 23  1 ? 11 
HELX_P HELX_P2  2  GLU A 62  ? ALA A 80  ? GLU A 62  ALA A 80  1 ? 19 
HELX_P HELX_P3  3  ILE A 107 ? GLY A 120 ? ILE A 107 GLY A 120 1 ? 14 
HELX_P HELX_P4  4  ALA A 131 ? PHE A 138 ? ALA A 131 PHE A 138 5 ? 8  
HELX_P HELX_P5  5  ALA A 147 ? ILE A 159 ? ALA A 147 ILE A 159 1 ? 13 
HELX_P HELX_P6  6  GLU A 161 ? ASN A 164 ? GLU A 161 ASN A 164 5 ? 4  
HELX_P HELX_P7  7  ASP A 171 ? GLY A 173 ? ASP A 171 GLY A 173 5 ? 3  
HELX_P HELX_P8  8  GLY A 174 ? ASN A 186 ? GLY A 174 ASN A 186 1 ? 13 
HELX_P HELX_P9  9  CYS A 226 ? ALA A 239 ? CYS A 226 ALA A 239 1 ? 14 
HELX_P HELX_P10 10 PRO A 256 ? ASN A 263 ? PRO A 256 ASN A 263 1 ? 8  
HELX_P HELX_P11 11 GLN A 277 ? LYS A 282 ? GLN A 277 LYS A 282 1 ? 6  
HELX_P HELX_P12 12 ILE A 292 ? GLY A 306 ? ILE A 292 GLY A 306 1 ? 15 
HELX_P HELX_P13 13 GLN B 13  ? GLY B 24  ? GLN B 13  GLY B 24  1 ? 12 
HELX_P HELX_P14 14 GLU B 62  ? ALA B 80  ? GLU B 62  ALA B 80  1 ? 19 
HELX_P HELX_P15 15 TYR B 94  ? ASP B 98  ? TYR B 94  ASP B 98  5 ? 5  
HELX_P HELX_P16 16 ILE B 107 ? ALA B 119 ? ILE B 107 ALA B 119 1 ? 13 
HELX_P HELX_P17 17 ALA B 131 ? PHE B 138 ? ALA B 131 PHE B 138 5 ? 8  
HELX_P HELX_P18 18 ALA B 147 ? ILE B 159 ? ALA B 147 ILE B 159 1 ? 13 
HELX_P HELX_P19 19 GLY B 174 ? ASN B 186 ? GLY B 174 ASN B 186 1 ? 13 
HELX_P HELX_P20 20 CYS B 226 ? ALA B 239 ? CYS B 226 ALA B 239 1 ? 14 
HELX_P HELX_P21 21 PRO B 256 ? ALA B 264 ? PRO B 256 ALA B 264 1 ? 9  
HELX_P HELX_P22 22 GLN B 277 ? HIS B 283 ? GLN B 277 HIS B 283 1 ? 7  
HELX_P HELX_P23 23 ILE B 292 ? GLY B 306 ? ILE B 292 GLY B 306 1 ? 15 
HELX_P HELX_P24 24 VAL B 309 ? PHE B 313 ? VAL B 309 PHE B 313 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
A ? 5 ? 
B ? 2 ? 
C ? 7 ? 
D ? 5 ? 
E ? 2 ? 
F ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
A 1 2 ? parallel      
A 2 3 ? parallel      
A 3 4 ? parallel      
A 4 5 ? parallel      
B 1 2 ? anti-parallel 
C 1 2 ? anti-parallel 
C 2 3 ? parallel      
C 3 4 ? parallel      
C 4 5 ? parallel      
C 5 6 ? parallel      
C 6 7 ? parallel      
D 1 2 ? parallel      
D 2 3 ? parallel      
D 3 4 ? parallel      
D 4 5 ? parallel      
E 1 2 ? anti-parallel 
F 1 2 ? anti-parallel 
F 2 3 ? parallel      
F 3 4 ? parallel      
F 4 5 ? parallel      
F 5 6 ? parallel      
F 6 7 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
A 1 ILE A 4   ? SER A 8   ? ILE A 4   SER A 8   
A 2 ASP A 52  ? VAL A 56  ? ASP A 52  VAL A 56  
A 3 ARG A 84  ? ILE A 89  ? ARG A 84  ILE A 89  
A 4 HIS A 123 ? MET A 127 ? HIS A 123 MET A 127 
A 5 VAL A 142 ? LEU A 145 ? VAL A 142 LEU A 145 
B 1 VAL A 30  ? LYS A 34  ? VAL A 30  LYS A 34  
B 2 THR A 40  ? ILE A 44  ? THR A 40  ILE A 44  
C 1 MET A 205 ? VAL A 208 ? MET A 205 VAL A 208 
C 2 ASP A 188 ? LYS A 194 ? ASP A 188 LYS A 194 
C 3 THR A 166 ? SER A 169 ? THR A 166 SER A 169 
C 4 ALA A 216 ? ALA A 223 ? ALA A 216 ALA A 223 
C 5 VAL A 244 ? GLY A 251 ? VAL A 244 GLY A 251 
C 6 ALA A 268 ? THR A 272 ? ALA A 268 THR A 272 
C 7 ILE A 287 ? ILE A 290 ? ILE A 287 ILE A 290 
D 1 ILE B 4   ? SER B 8   ? ILE B 4   SER B 8   
D 2 ASP B 52  ? VAL B 56  ? ASP B 52  VAL B 56  
D 3 ARG B 84  ? ILE B 89  ? ARG B 84  ILE B 89  
D 4 HIS B 123 ? MET B 127 ? HIS B 123 MET B 127 
D 5 VAL B 142 ? LEU B 145 ? VAL B 142 LEU B 145 
E 1 LYS B 33  ? LYS B 34  ? LYS B 33  LYS B 34  
E 2 THR B 40  ? CYS B 41  ? THR B 40  CYS B 41  
F 1 ARG B 204 ? VAL B 208 ? ARG B 204 VAL B 208 
F 2 ASP B 188 ? GLU B 195 ? ASP B 188 GLU B 195 
F 3 THR B 166 ? SER B 169 ? THR B 166 SER B 169 
F 4 VAL B 215 ? ALA B 223 ? VAL B 215 ALA B 223 
F 5 ARG B 243 ? GLY B 251 ? ARG B 243 GLY B 251 
F 6 PHE B 266 ? THR B 272 ? PHE B 266 THR B 272 
F 7 ILE B 287 ? ILE B 290 ? ILE B 287 ILE B 290 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
A 1 2 N PHE A 7   ? N PHE A 7   O TYR A 54  ? O TYR A 54  
A 2 3 N VAL A 53  ? N VAL A 53  O ARG A 84  ? O ARG A 84  
A 3 4 N ILE A 89  ? N ILE A 89  O ILE A 125 ? O ILE A 125 
A 4 5 N THR A 126 ? N THR A 126 O LEU A 145 ? O LEU A 145 
B 1 2 N LYS A 33  ? N LYS A 33  O CYS A 41  ? O CYS A 41  
C 1 2 O VAL A 208 ? O VAL A 208 N LEU A 191 ? N LEU A 191 
C 2 3 O ASP A 188 ? O ASP A 188 N ILE A 167 ? N ILE A 167 
C 3 4 N VAL A 168 ? N VAL A 168 O ILE A 217 ? O ILE A 217 
C 4 5 N LEU A 218 ? N LEU A 218 O TYR A 245 ? O TYR A 245 
C 5 6 N LEU A 248 ? N LEU A 248 O VAL A 270 ? O VAL A 270 
C 6 7 N VAL A 271 ? N VAL A 271 O ILE A 290 ? O ILE A 290 
D 1 2 N PHE B 7   ? N PHE B 7   O TYR B 54  ? O TYR B 54  
D 2 3 N ILE B 55  ? N ILE B 55  O VAL B 88  ? O VAL B 88  
D 3 4 N ALA B 87  ? N ALA B 87  O ILE B 125 ? O ILE B 125 
D 4 5 N THR B 126 ? N THR B 126 O LEU B 145 ? O LEU B 145 
E 1 2 N LYS B 33  ? N LYS B 33  O CYS B 41  ? O CYS B 41  
F 1 2 O VAL B 206 ? O VAL B 206 N HIS B 193 ? N HIS B 193 
F 2 3 O ILE B 192 ? O ILE B 192 N SER B 169 ? N SER B 169 
F 3 4 N VAL B 168 ? N VAL B 168 O ILE B 217 ? O ILE B 217 
F 4 5 N LEU B 218 ? N LEU B 218 O TYR B 245 ? O TYR B 245 
F 5 6 N VAL B 244 ? N VAL B 244 O GLU B 267 ? O GLU B 267 
F 6 7 N VAL B 269 ? N VAL B 269 O GLN B 288 ? O GLN B 288 
# 
loop_
_struct_site.id 
_struct_site.pdbx_evidence_code 
_struct_site.pdbx_auth_asym_id 
_struct_site.pdbx_auth_comp_id 
_struct_site.pdbx_auth_seq_id 
_struct_site.pdbx_auth_ins_code 
_struct_site.pdbx_num_residues 
_struct_site.details 
AC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE SO4 A 1001' 
AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE SO4 A 1002' 
AC3 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE SO4 B 401'  
AC4 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE SO4 B 402'  
AC5 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE SO4 B 403'  
# 
loop_
_struct_site_gen.id 
_struct_site_gen.site_id 
_struct_site_gen.pdbx_num_res 
_struct_site_gen.label_comp_id 
_struct_site_gen.label_asym_id 
_struct_site_gen.label_seq_id 
_struct_site_gen.pdbx_auth_ins_code 
_struct_site_gen.auth_comp_id 
_struct_site_gen.auth_asym_id 
_struct_site_gen.auth_seq_id 
_struct_site_gen.label_atom_id 
_struct_site_gen.label_alt_id 
_struct_site_gen.symmetry 
_struct_site_gen.details 
1  AC1 6 SER A 47  ? SER A 47  . ? 3_555 ? 
2  AC1 6 ARG A 49  ? ARG A 49  . ? 3_555 ? 
3  AC1 6 SER A 308 ? SER A 308 . ? 1_555 ? 
4  AC1 6 VAL A 309 ? VAL A 309 . ? 1_555 ? 
5  AC1 6 SER A 310 ? SER A 310 . ? 1_555 ? 
6  AC1 6 ARG B 104 ? ARG B 104 . ? 3_555 ? 
7  AC2 4 ASP A 224 ? ASP A 224 . ? 1_555 ? 
8  AC2 4 THR A 225 ? THR A 225 . ? 1_555 ? 
9  AC2 4 CYS A 226 ? CYS A 226 . ? 1_555 ? 
10 AC2 4 THR A 228 ? THR A 228 . ? 1_555 ? 
11 AC3 6 ARG A 104 ? ARG A 104 . ? 2_555 ? 
12 AC3 6 SER B 47  ? SER B 47  . ? 2_555 ? 
13 AC3 6 ARG B 49  ? ARG B 49  . ? 2_555 ? 
14 AC3 6 SER B 308 ? SER B 308 . ? 1_555 ? 
15 AC3 6 VAL B 309 ? VAL B 309 . ? 1_555 ? 
16 AC3 6 SER B 310 ? SER B 310 . ? 1_555 ? 
17 AC4 5 ASP B 224 ? ASP B 224 . ? 1_555 ? 
18 AC4 5 THR B 225 ? THR B 225 . ? 1_555 ? 
19 AC4 5 CYS B 226 ? CYS B 226 . ? 1_555 ? 
20 AC4 5 GLY B 227 ? GLY B 227 . ? 1_555 ? 
21 AC4 5 THR B 228 ? THR B 228 . ? 1_555 ? 
22 AC5 8 LYS A 99  ? LYS A 99  . ? 2_555 ? 
23 AC5 8 LYS A 100 ? LYS A 100 . ? 2_555 ? 
24 AC5 8 ASP A 101 ? ASP A 101 . ? 2_555 ? 
25 AC5 8 LYS A 102 ? LYS A 102 . ? 2_555 ? 
26 AC5 8 SER B 132 ? SER B 132 . ? 1_555 ? 
27 AC5 8 GLN B 135 ? GLN B 135 . ? 1_555 ? 
28 AC5 8 ASN B 144 ? ASN B 144 . ? 1_555 ? 
29 AC5 8 TYR B 146 ? TYR B 146 . ? 1_555 ? 
# 
_database_PDB_matrix.entry_id          4LYG 
_database_PDB_matrix.origx[1][1]       1.000000 
_database_PDB_matrix.origx[1][2]       0.000000 
_database_PDB_matrix.origx[1][3]       0.000000 
_database_PDB_matrix.origx[2][1]       0.000000 
_database_PDB_matrix.origx[2][2]       1.000000 
_database_PDB_matrix.origx[2][3]       0.000000 
_database_PDB_matrix.origx[3][1]       0.000000 
_database_PDB_matrix.origx[3][2]       0.000000 
_database_PDB_matrix.origx[3][3]       1.000000 
_database_PDB_matrix.origx_vector[1]   0.00000 
_database_PDB_matrix.origx_vector[2]   0.00000 
_database_PDB_matrix.origx_vector[3]   0.00000 
# 
_atom_sites.entry_id                    4LYG 
_atom_sites.fract_transf_matrix[1][1]   0.005900 
_atom_sites.fract_transf_matrix[1][2]   0.003406 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006812 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.016163 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASN A 1 3   ? -11.648 -4.210  -49.524 1.00  38.73 ? 3    ASN A N   1 
ATOM   2    C CA  . ASN A 1 3   ? -10.850 -3.588  -48.429 1.00  38.52 ? 3    ASN A CA  1 
ATOM   3    C C   . ASN A 1 3   ? -11.747 -3.095  -47.297 1.00  37.83 ? 3    ASN A C   1 
ATOM   4    O O   . ASN A 1 3   ? -11.634 -3.577  -46.182 1.00  37.54 ? 3    ASN A O   1 
ATOM   5    C CB  . ASN A 1 3   ? -9.965  -2.448  -48.960 1.00  38.79 ? 3    ASN A CB  1 
ATOM   6    C CG  . ASN A 1 3   ? -8.657  -2.298  -48.173 1.00  40.13 ? 3    ASN A CG  1 
ATOM   7    O OD1 . ASN A 1 3   ? -8.002  -3.284  -47.840 1.00  40.73 ? 3    ASN A OD1 1 
ATOM   8    N ND2 . ASN A 1 3   ? -8.258  -1.057  -47.908 1.00  42.53 ? 3    ASN A ND2 1 
ATOM   9    N N   . ILE A 1 4   ? -12.642 -2.152  -47.586 1.00  37.15 ? 4    ILE A N   1 
ATOM   10   C CA  . ILE A 1 4   ? -13.583 -1.666  -46.584 1.00  36.62 ? 4    ILE A CA  1 
ATOM   11   C C   . ILE A 1 4   ? -14.702 -2.679  -46.356 1.00  36.31 ? 4    ILE A C   1 
ATOM   12   O O   . ILE A 1 4   ? -15.138 -3.357  -47.294 1.00  36.26 ? 4    ILE A O   1 
ATOM   13   C CB  . ILE A 1 4   ? -14.154 -0.283  -46.937 1.00  36.80 ? 4    ILE A CB  1 
ATOM   14   C CG1 . ILE A 1 4   ? -15.222 0.155   -45.914 1.00  36.89 ? 4    ILE A CG1 1 
ATOM   15   C CG2 . ILE A 1 4   ? -14.694 -0.271  -48.372 1.00  37.97 ? 4    ILE A CG2 1 
ATOM   16   C CD1 . ILE A 1 4   ? -15.498 1.649   -45.909 1.00  37.27 ? 4    ILE A CD1 1 
ATOM   17   N N   . LYS A 1 5   ? -15.141 -2.793  -45.099 1.00  35.60 ? 5    LYS A N   1 
ATOM   18   C CA  . LYS A 1 5   ? -16.198 -3.706  -44.725 1.00  34.91 ? 5    LYS A CA  1 
ATOM   19   C C   . LYS A 1 5   ? -17.068 -3.073  -43.639 1.00  34.63 ? 5    LYS A C   1 
ATOM   20   O O   . LYS A 1 5   ? -16.562 -2.711  -42.584 1.00  35.11 ? 5    LYS A O   1 
ATOM   21   C CB  . LYS A 1 5   ? -15.591 -5.021  -44.253 1.00  34.71 ? 5    LYS A CB  1 
ATOM   22   C CG  . LYS A 1 5   ? -15.618 -6.136  -45.272 1.00  35.76 ? 5    LYS A CG  1 
ATOM   23   C CD  . LYS A 1 5   ? -16.943 -6.933  -45.163 1.00  37.75 ? 5    LYS A CD  1 
ATOM   24   C CE  . LYS A 1 5   ? -17.442 -7.401  -46.550 1.00  38.56 ? 5    LYS A CE  1 
ATOM   25   N NZ  . LYS A 1 5   ? -18.890 -7.064  -46.792 1.00  37.34 ? 5    LYS A NZ  1 
ATOM   26   N N   . ILE A 1 6   ? -18.368 -2.912  -43.909 1.00  34.41 ? 6    ILE A N   1 
ATOM   27   C CA  . ILE A 1 6   ? -19.318 -2.367  -42.917 1.00  33.77 ? 6    ILE A CA  1 
ATOM   28   C C   . ILE A 1 6   ? -20.149 -3.456  -42.243 1.00  33.75 ? 6    ILE A C   1 
ATOM   29   O O   . ILE A 1 6   ? -20.842 -4.214  -42.900 1.00  33.66 ? 6    ILE A O   1 
ATOM   30   C CB  . ILE A 1 6   ? -20.274 -1.310  -43.531 1.00  33.50 ? 6    ILE A CB  1 
ATOM   31   C CG1 . ILE A 1 6   ? -19.482 -0.258  -44.304 1.00  34.69 ? 6    ILE A CG1 1 
ATOM   32   C CG2 . ILE A 1 6   ? -21.092 -0.635  -42.461 1.00  31.74 ? 6    ILE A CG2 1 
ATOM   33   C CD1 . ILE A 1 6   ? -20.353 0.780   -45.018 1.00  35.96 ? 6    ILE A CD1 1 
ATOM   34   N N   . PHE A 1 7   ? -20.062 -3.516  -40.924 1.00  34.31 ? 7    PHE A N   1 
ATOM   35   C CA  . PHE A 1 7   ? -20.910 -4.373  -40.111 1.00  35.28 ? 7    PHE A CA  1 
ATOM   36   C C   . PHE A 1 7   ? -21.887 -3.541  -39.266 1.00  36.72 ? 7    PHE A C   1 
ATOM   37   O O   . PHE A 1 7   ? -21.586 -2.410  -38.883 1.00  36.94 ? 7    PHE A O   1 
ATOM   38   C CB  . PHE A 1 7   ? -20.046 -5.225  -39.178 1.00  34.71 ? 7    PHE A CB  1 
ATOM   39   C CG  . PHE A 1 7   ? -19.174 -6.215  -39.885 1.00  33.25 ? 7    PHE A CG  1 
ATOM   40   C CD1 . PHE A 1 7   ? -17.886 -5.877  -40.281 1.00  32.74 ? 7    PHE A CD1 1 
ATOM   41   C CD2 . PHE A 1 7   ? -19.633 -7.489  -40.155 1.00  31.68 ? 7    PHE A CD2 1 
ATOM   42   C CE1 . PHE A 1 7   ? -17.087 -6.805  -40.928 1.00  31.11 ? 7    PHE A CE1 1 
ATOM   43   C CE2 . PHE A 1 7   ? -18.841 -8.408  -40.801 1.00  29.57 ? 7    PHE A CE2 1 
ATOM   44   C CZ  . PHE A 1 7   ? -17.578 -8.080  -41.176 1.00  29.79 ? 7    PHE A CZ  1 
ATOM   45   N N   . SER A 1 8   ? -23.043 -4.119  -38.956 1.00  38.48 ? 8    SER A N   1 
ATOM   46   C CA  . SER A 1 8   ? -24.047 -3.449  -38.144 1.00  40.18 ? 8    SER A CA  1 
ATOM   47   C C   . SER A 1 8   ? -24.044 -4.038  -36.742 1.00  41.74 ? 8    SER A C   1 
ATOM   48   O O   . SER A 1 8   ? -23.489 -5.119  -36.520 1.00  41.80 ? 8    SER A O   1 
ATOM   49   C CB  . SER A 1 8   ? -25.363 -3.389  -38.904 1.00  39.98 ? 8    SER A CB  1 
ATOM   50   O OG  . SER A 1 8   ? -26.406 -2.934  -38.060 1.00  40.06 ? 8    SER A OG  1 
ATOM   51   N N   . GLY A 1 9   ? -24.691 -3.316  -35.833 1.00  43.86 ? 9    GLY A N   1 
ATOM   52   C CA  . GLY A 1 9   ? -25.014 -3.761  -34.483 1.00  45.76 ? 9    GLY A CA  1 
ATOM   53   C C   . GLY A 1 9   ? -26.312 -4.552  -34.325 1.00  47.32 ? 9    GLY A C   1 
ATOM   54   O O   . GLY A 1 9   ? -26.441 -5.643  -34.855 1.00  47.52 ? 9    GLY A O   1 
ATOM   55   N N   . SER A 1 10  ? -27.276 -4.034  -33.588 1.00  48.44 ? 10   SER A N   1 
ATOM   56   C CA  . SER A 1 10  ? -28.425 -4.861  -33.239 1.00  49.82 ? 10   SER A CA  1 
ATOM   57   C C   . SER A 1 10  ? -29.275 -4.910  -34.456 1.00  49.97 ? 10   SER A C   1 
ATOM   58   O O   . SER A 1 10  ? -28.900 -4.422  -35.486 1.00  50.18 ? 10   SER A O   1 
ATOM   59   C CB  . SER A 1 10  ? -29.364 -4.144  -32.288 1.00  50.44 ? 10   SER A CB  1 
ATOM   60   N N   . SER A 1 11  ? -30.424 -5.550  -34.335 1.00  50.14 ? 11   SER A N   1 
ATOM   61   C CA  . SER A 1 11  ? -31.381 -5.544  -35.405 1.00  50.45 ? 11   SER A CA  1 
ATOM   62   C C   . SER A 1 11  ? -31.520 -4.209  -36.001 1.00  50.32 ? 11   SER A C   1 
ATOM   63   O O   . SER A 1 11  ? -31.907 -4.058  -37.148 1.00  50.62 ? 11   SER A O   1 
ATOM   64   C CB  . SER A 1 11  ? -32.768 -5.999  -34.981 1.00  50.81 ? 11   SER A CB  1 
ATOM   65   O OG  . SER A 1 11  ? -33.752 -5.676  -35.970 1.00  51.05 ? 11   SER A OG  1 
ATOM   66   N N   . HIS A 1 12  ? -31.236 -3.199  -35.209 0.58  49.83 ? 12   HIS A N   1 
ATOM   67   C CA  . HIS A 1 12  ? -31.355 -1.881  -35.795 0.58  49.47 ? 12   HIS A CA  1 
ATOM   68   C C   . HIS A 1 12  ? -30.396 -2.110  -36.951 0.58  49.01 ? 12   HIS A C   1 
ATOM   69   O O   . HIS A 1 12  ? -29.203 -2.390  -36.765 0.58  49.11 ? 12   HIS A O   1 
ATOM   70   C CB  . HIS A 1 12  ? -31.013 -0.799  -34.776 0.58  49.75 ? 12   HIS A CB  1 
ATOM   71   C CG  . HIS A 1 12  ? -30.530 0.477   -35.393 0.58  51.25 ? 12   HIS A CG  1 
ATOM   72   N ND1 . HIS A 1 12  ? -29.217 0.896   -35.306 0.58  52.30 ? 12   HIS A ND1 1 
ATOM   73   C CD2 . HIS A 1 12  ? -31.174 1.409   -36.136 0.58  51.98 ? 12   HIS A CD2 1 
ATOM   74   C CE1 . HIS A 1 12  ? -29.081 2.044   -35.945 0.58  52.20 ? 12   HIS A CE1 1 
ATOM   75   N NE2 . HIS A 1 12  ? -30.254 2.378   -36.455 0.58  52.58 ? 12   HIS A NE2 1 
ATOM   76   N N   . GLN A 1 13  ? -30.950 -2.013  -38.153 1.00  48.36 ? 13   GLN A N   1 
ATOM   77   C CA  . GLN A 1 13  ? -30.216 -2.328  -39.358 1.00  47.76 ? 13   GLN A CA  1 
ATOM   78   C C   . GLN A 1 13  ? -30.541 -1.273  -40.398 1.00  46.97 ? 13   GLN A C   1 
ATOM   79   O O   . GLN A 1 13  ? -29.995 -1.303  -41.492 1.00  47.08 ? 13   GLN A O   1 
ATOM   80   C CB  . GLN A 1 13  ? -30.495 -3.678  -40.011 1.00  48.20 ? 13   GLN A CB  1 
ATOM   81   C CG  . GLN A 1 13  ? -29.511 -4.783  -39.627 1.00  49.03 ? 13   GLN A CG  1 
ATOM   82   C CD  . GLN A 1 13  ? -29.050 -5.585  -40.848 1.00  51.24 ? 13   GLN A CD  1 
ATOM   83   O OE1 . GLN A 1 13  ? -28.327 -6.580  -40.715 1.00  51.86 ? 13   GLN A OE1 1 
ATOM   84   N NE2 . GLN A 1 13  ? -29.457 -5.142  -42.048 1.00  51.53 ? 13   GLN A NE2 1 
ATOM   85   N N   . ASP A 1 14  ? -31.404 -0.328  -40.061 1.00  46.18 ? 14   ASP A N   1 
ATOM   86   C CA  . ASP A 1 14  ? -31.802 0.660   -41.043 1.00  45.75 ? 14   ASP A CA  1 
ATOM   87   C C   . ASP A 1 14  ? -30.630 1.604   -41.353 1.00  45.16 ? 14   ASP A C   1 
ATOM   88   O O   . ASP A 1 14  ? -30.213 1.714   -42.511 1.00  45.16 ? 14   ASP A O   1 
ATOM   89   C CB  . ASP A 1 14  ? -33.037 1.439   -40.611 1.00  46.05 ? 14   ASP A CB  1 
ATOM   90   C CG  . ASP A 1 14  ? -33.563 2.321   -41.716 1.00  47.71 ? 14   ASP A CG  1 
ATOM   91   O OD1 . ASP A 1 14  ? -33.797 3.526   -41.468 1.00  49.49 ? 14   ASP A OD1 1 
ATOM   92   O OD2 . ASP A 1 14  ? -33.709 1.809   -42.853 1.00  50.20 ? 14   ASP A OD2 1 
ATOM   93   N N   . LEU A 1 15  ? -30.099 2.263   -40.321 1.00  44.19 ? 15   LEU A N   1 
ATOM   94   C CA  . LEU A 1 15  ? -29.040 3.260   -40.474 1.00  43.14 ? 15   LEU A CA  1 
ATOM   95   C C   . LEU A 1 15  ? -27.806 2.669   -41.143 1.00  43.14 ? 15   LEU A C   1 
ATOM   96   O O   . LEU A 1 15  ? -27.214 3.289   -42.034 1.00  43.47 ? 15   LEU A O   1 
ATOM   97   C CB  . LEU A 1 15  ? -28.653 3.833   -39.111 1.00  42.78 ? 15   LEU A CB  1 
ATOM   98   C CG  . LEU A 1 15  ? -28.197 5.279   -38.880 1.00  41.65 ? 15   LEU A CG  1 
ATOM   99   C CD1 . LEU A 1 15  ? -27.190 5.259   -37.743 1.00  40.95 ? 15   LEU A CD1 1 
ATOM   100  C CD2 . LEU A 1 15  ? -27.610 5.986   -40.106 1.00  40.17 ? 15   LEU A CD2 1 
ATOM   101  N N   . SER A 1 16  ? -27.421 1.468   -40.713 1.00  42.82 ? 16   SER A N   1 
ATOM   102  C CA  . SER A 1 16  ? -26.239 0.789   -41.252 1.00  42.30 ? 16   SER A CA  1 
ATOM   103  C C   . SER A 1 16  ? -26.451 0.320   -42.669 1.00  41.95 ? 16   SER A C   1 
ATOM   104  O O   . SER A 1 16  ? -25.489 0.174   -43.419 1.00  42.12 ? 16   SER A O   1 
ATOM   105  C CB  . SER A 1 16  ? -25.879 -0.411  -40.398 1.00  42.41 ? 16   SER A CB  1 
ATOM   106  O OG  . SER A 1 16  ? -25.500 -0.003  -39.099 1.00  43.57 ? 16   SER A OG  1 
ATOM   107  N N   . GLN A 1 17  ? -27.706 0.061   -43.025 1.00  41.45 ? 17   GLN A N   1 
ATOM   108  C CA  . GLN A 1 17  ? -28.064 -0.333  -44.383 1.00  41.01 ? 17   GLN A CA  1 
ATOM   109  C C   . GLN A 1 17  ? -28.026 0.892   -45.300 1.00  40.17 ? 17   GLN A C   1 
ATOM   110  O O   . GLN A 1 17  ? -27.619 0.795   -46.451 1.00  40.05 ? 17   GLN A O   1 
ATOM   111  C CB  . GLN A 1 17  ? -29.455 -0.988  -44.393 1.00  41.41 ? 17   GLN A CB  1 
ATOM   112  C CG  . GLN A 1 17  ? -29.965 -1.458  -45.750 1.00  42.96 ? 17   GLN A CG  1 
ATOM   113  C CD  . GLN A 1 17  ? -29.241 -2.695  -46.245 1.00  45.62 ? 17   GLN A CD  1 
ATOM   114  O OE1 . GLN A 1 17  ? -29.157 -3.701  -45.530 1.00  45.98 ? 17   GLN A OE1 1 
ATOM   115  N NE2 . GLN A 1 17  ? -28.709 -2.626  -47.476 1.00  46.68 ? 17   GLN A NE2 1 
ATOM   116  N N   . LYS A 1 18  ? -28.458 2.036   -44.778 1.00  39.25 ? 18   LYS A N   1 
ATOM   117  C CA  . LYS A 1 18  ? -28.443 3.278   -45.529 1.00  38.58 ? 18   LYS A CA  1 
ATOM   118  C C   . LYS A 1 18  ? -27.006 3.692   -45.820 1.00  38.11 ? 18   LYS A C   1 
ATOM   119  O O   . LYS A 1 18  ? -26.702 4.182   -46.914 1.00  38.02 ? 18   LYS A O   1 
ATOM   120  C CB  . LYS A 1 18  ? -29.196 4.383   -44.779 1.00  38.65 ? 18   LYS A CB  1 
ATOM   121  C CG  . LYS A 1 18  ? -30.691 4.429   -45.103 1.00  39.49 ? 18   LYS A CG  1 
ATOM   122  C CD  . LYS A 1 18  ? -31.437 5.423   -44.193 1.00  41.97 ? 18   LYS A CD  1 
ATOM   123  C CE  . LYS A 1 18  ? -32.888 5.642   -44.638 1.00  43.29 ? 18   LYS A CE  1 
ATOM   124  N NZ  . LYS A 1 18  ? -33.566 4.398   -45.205 1.00  45.19 ? 18   LYS A NZ  1 
ATOM   125  N N   . ILE A 1 19  ? -26.125 3.475   -44.845 1.00  37.40 ? 19   ILE A N   1 
ATOM   126  C CA  . ILE A 1 19  ? -24.711 3.789   -45.001 1.00  36.69 ? 19   ILE A CA  1 
ATOM   127  C C   . ILE A 1 19  ? -24.095 2.884   -46.071 1.00  36.36 ? 19   ILE A C   1 
ATOM   128  O O   . ILE A 1 19  ? -23.483 3.377   -47.024 1.00  36.30 ? 19   ILE A O   1 
ATOM   129  C CB  . ILE A 1 19  ? -23.946 3.698   -43.651 1.00  36.62 ? 19   ILE A CB  1 
ATOM   130  C CG1 . ILE A 1 19  ? -24.379 4.844   -42.735 1.00  36.33 ? 19   ILE A CG1 1 
ATOM   131  C CG2 . ILE A 1 19  ? -22.432 3.780   -43.874 1.00  36.26 ? 19   ILE A CG2 1 
ATOM   132  C CD1 . ILE A 1 19  ? -24.366 4.499   -41.230 1.00  35.77 ? 19   ILE A CD1 1 
ATOM   133  N N   . ALA A 1 20  ? -24.288 1.573   -45.932 1.00  35.84 ? 20   ALA A N   1 
ATOM   134  C CA  . ALA A 1 20  ? -23.705 0.606   -46.876 1.00  35.63 ? 20   ALA A CA  1 
ATOM   135  C C   . ALA A 1 20  ? -24.138 0.863   -48.327 1.00  35.69 ? 20   ALA A C   1 
ATOM   136  O O   . ALA A 1 20  ? -23.364 0.629   -49.264 1.00  35.19 ? 20   ALA A O   1 
ATOM   137  C CB  . ALA A 1 20  ? -24.014 -0.811  -46.463 1.00  35.21 ? 20   ALA A CB  1 
ATOM   138  N N   . ASP A 1 21  ? -25.366 1.362   -48.495 1.00  35.94 ? 21   ASP A N   1 
ATOM   139  C CA  . ASP A 1 21  ? -25.886 1.768   -49.800 1.00  36.51 ? 21   ASP A CA  1 
ATOM   140  C C   . ASP A 1 21  ? -25.091 2.926   -50.433 1.00  36.14 ? 21   ASP A C   1 
ATOM   141  O O   . ASP A 1 21  ? -24.626 2.825   -51.579 1.00  35.99 ? 21   ASP A O   1 
ATOM   142  C CB  . ASP A 1 21  ? -27.367 2.145   -49.696 1.00  37.02 ? 21   ASP A CB  1 
ATOM   143  C CG  . ASP A 1 21  ? -28.264 0.936   -49.534 1.00  39.72 ? 21   ASP A CG  1 
ATOM   144  O OD1 . ASP A 1 21  ? -27.728 -0.201  -49.475 1.00  42.97 ? 21   ASP A OD1 1 
ATOM   145  O OD2 . ASP A 1 21  ? -29.508 1.115   -49.451 1.00  42.22 ? 21   ASP A OD2 1 
ATOM   146  N N   . ARG A 1 22  ? -24.928 4.009   -49.679 0.80  35.24 ? 22   ARG A N   1 
ATOM   147  C CA  . ARG A 1 22  ? -24.254 5.195   -50.178 0.80  34.81 ? 22   ARG A CA  1 
ATOM   148  C C   . ARG A 1 22  ? -22.796 4.917   -50.539 0.80  34.58 ? 22   ARG A C   1 
ATOM   149  O O   . ARG A 1 22  ? -22.156 5.695   -51.263 0.80  34.74 ? 22   ARG A O   1 
ATOM   150  C CB  . ARG A 1 22  ? -24.347 6.331   -49.161 0.80  34.71 ? 22   ARG A CB  1 
ATOM   151  C CG  . ARG A 1 22  ? -25.757 6.785   -48.899 0.80  35.42 ? 22   ARG A CG  1 
ATOM   152  C CD  . ARG A 1 22  ? -25.813 8.024   -48.053 0.80  36.38 ? 22   ARG A CD  1 
ATOM   153  N NE  . ARG A 1 22  ? -27.197 8.429   -47.780 0.80  37.71 ? 22   ARG A NE  1 
ATOM   154  C CZ  . ARG A 1 22  ? -27.909 9.250   -48.559 0.80  38.01 ? 22   ARG A CZ  1 
ATOM   155  N NH1 . ARG A 1 22  ? -27.361 9.751   -49.661 0.80  37.47 ? 22   ARG A NH1 1 
ATOM   156  N NH2 . ARG A 1 22  ? -29.171 9.565   -48.252 0.80  36.98 ? 22   ARG A NH2 1 
ATOM   157  N N   . LEU A 1 23  ? -22.272 3.807   -50.036 1.00  34.04 ? 23   LEU A N   1 
ATOM   158  C CA  . LEU A 1 23  ? -20.897 3.438   -50.323 1.00  33.18 ? 23   LEU A CA  1 
ATOM   159  C C   . LEU A 1 23  ? -20.827 2.326   -51.349 1.00  32.78 ? 23   LEU A C   1 
ATOM   160  O O   . LEU A 1 23  ? -19.737 1.968   -51.785 1.00  33.24 ? 23   LEU A O   1 
ATOM   161  C CB  . LEU A 1 23  ? -20.158 3.050   -49.045 1.00  33.00 ? 23   LEU A CB  1 
ATOM   162  C CG  . LEU A 1 23  ? -19.835 4.176   -48.054 1.00  32.52 ? 23   LEU A CG  1 
ATOM   163  C CD1 . LEU A 1 23  ? -19.557 3.564   -46.687 1.00  33.07 ? 23   LEU A CD1 1 
ATOM   164  C CD2 . LEU A 1 23  ? -18.660 5.042   -48.504 1.00  30.36 ? 23   LEU A CD2 1 
ATOM   165  N N   . GLY A 1 24  ? -21.984 1.795   -51.740 1.00  31.94 ? 24   GLY A N   1 
ATOM   166  C CA  . GLY A 1 24  ? -22.039 0.741   -52.745 1.00  30.84 ? 24   GLY A CA  1 
ATOM   167  C C   . GLY A 1 24  ? -21.548 -0.584  -52.206 1.00  30.18 ? 24   GLY A C   1 
ATOM   168  O O   . GLY A 1 24  ? -20.819 -1.306  -52.873 1.00  29.88 ? 24   GLY A O   1 
ATOM   169  N N   . LEU A 1 25  ? -21.957 -0.899  -50.984 1.00  29.85 ? 25   LEU A N   1 
ATOM   170  C CA  . LEU A 1 25  ? -21.529 -2.118  -50.320 1.00  29.35 ? 25   LEU A CA  1 
ATOM   171  C C   . LEU A 1 25  ? -22.740 -2.840  -49.785 1.00  29.47 ? 25   LEU A C   1 
ATOM   172  O O   . LEU A 1 25  ? -23.835 -2.239  -49.644 1.00  30.00 ? 25   LEU A O   1 
ATOM   173  C CB  . LEU A 1 25  ? -20.577 -1.795  -49.161 1.00  28.74 ? 25   LEU A CB  1 
ATOM   174  C CG  . LEU A 1 25  ? -19.256 -1.100  -49.475 1.00  28.44 ? 25   LEU A CG  1 
ATOM   175  C CD1 . LEU A 1 25  ? -18.651 -0.538  -48.182 1.00  29.08 ? 25   LEU A CD1 1 
ATOM   176  C CD2 . LEU A 1 25  ? -18.270 -2.067  -50.178 1.00  28.30 ? 25   LEU A CD2 1 
ATOM   177  N N   . GLU A 1 26  ? -22.561 -4.134  -49.513 0.40  29.40 ? 26   GLU A N   1 
ATOM   178  C CA  . GLU A 1 26  ? -23.513 -4.860  -48.699 0.40  29.25 ? 26   GLU A CA  1 
ATOM   179  C C   . GLU A 1 26  ? -22.886 -4.951  -47.328 0.40  29.29 ? 26   GLU A C   1 
ATOM   180  O O   . GLU A 1 26  ? -21.684 -5.171  -47.212 0.40  29.14 ? 26   GLU A O   1 
ATOM   181  C CB  . GLU A 1 26  ? -23.780 -6.255  -49.265 0.40  29.03 ? 26   GLU A CB  1 
ATOM   182  C CG  . GLU A 1 26  ? -24.831 -6.301  -50.356 0.40  28.88 ? 26   GLU A CG  1 
ATOM   183  C CD  . GLU A 1 26  ? -24.844 -7.638  -51.077 0.40  29.96 ? 26   GLU A CD  1 
ATOM   184  O OE1 . GLU A 1 26  ? -24.160 -8.568  -50.587 0.40  30.34 ? 26   GLU A OE1 1 
ATOM   185  O OE2 . GLU A 1 26  ? -25.534 -7.761  -52.121 0.40  28.93 ? 26   GLU A OE2 1 
ATOM   186  N N   . LEU A 1 27  ? -23.697 -4.738  -46.297 1.00  29.69 ? 27   LEU A N   1 
ATOM   187  C CA  . LEU A 1 27  ? -23.297 -5.017  -44.911 1.00  30.48 ? 27   LEU A CA  1 
ATOM   188  C C   . LEU A 1 27  ? -22.699 -6.416  -44.793 1.00  30.99 ? 27   LEU A C   1 
ATOM   189  O O   . LEU A 1 27  ? -23.167 -7.364  -45.434 1.00  31.14 ? 27   LEU A O   1 
ATOM   190  C CB  . LEU A 1 27  ? -24.493 -4.905  -43.950 1.00  30.07 ? 27   LEU A CB  1 
ATOM   191  C CG  . LEU A 1 27  ? -25.018 -3.510  -43.623 1.00  29.98 ? 27   LEU A CG  1 
ATOM   192  C CD1 . LEU A 1 27  ? -26.421 -3.603  -43.018 1.00  32.57 ? 27   LEU A CD1 1 
ATOM   193  C CD2 . LEU A 1 27  ? -24.097 -2.794  -42.685 1.00  28.48 ? 27   LEU A CD2 1 
ATOM   194  N N   . GLY A 1 28  ? -21.658 -6.538  -43.986 1.00  31.61 ? 28   GLY A N   1 
ATOM   195  C CA  . GLY A 1 28  ? -21.002 -7.823  -43.777 1.00  32.78 ? 28   GLY A CA  1 
ATOM   196  C C   . GLY A 1 28  ? -21.899 -8.844  -43.104 1.00  33.57 ? 28   GLY A C   1 
ATOM   197  O O   . GLY A 1 28  ? -22.845 -8.479  -42.395 1.00  33.63 ? 28   GLY A O   1 
ATOM   198  N N   . LYS A 1 29  ? -21.608 -10.120 -43.343 0.40  34.24 ? 29   LYS A N   1 
ATOM   199  C CA  . LYS A 1 29  ? -22.356 -11.205 -42.735 0.40  35.10 ? 29   LYS A CA  1 
ATOM   200  C C   . LYS A 1 29  ? -21.885 -11.409 -41.310 0.40  36.01 ? 29   LYS A C   1 
ATOM   201  O O   . LYS A 1 29  ? -20.692 -11.524 -41.053 0.40  35.92 ? 29   LYS A O   1 
ATOM   202  C CB  . LYS A 1 29  ? -22.184 -12.499 -43.529 0.40  35.09 ? 29   LYS A CB  1 
ATOM   203  C CG  . LYS A 1 29  ? -22.825 -12.496 -44.923 0.40  35.02 ? 29   LYS A CG  1 
ATOM   204  C CD  . LYS A 1 29  ? -22.818 -13.902 -45.534 0.40  34.96 ? 29   LYS A CD  1 
ATOM   205  C CE  . LYS A 1 29  ? -21.393 -14.466 -45.678 0.40  34.36 ? 29   LYS A CE  1 
ATOM   206  N NZ  . LYS A 1 29  ? -20.826 -14.257 -47.068 0.40  33.85 ? 29   LYS A NZ  1 
ATOM   207  N N   . VAL A 1 30  ? -22.842 -11.440 -40.391 1.00  37.49 ? 30   VAL A N   1 
ATOM   208  C CA  . VAL A 1 30  ? -22.598 -11.723 -38.975 1.00  39.32 ? 30   VAL A CA  1 
ATOM   209  C C   . VAL A 1 30  ? -23.789 -12.472 -38.359 1.00  40.50 ? 30   VAL A C   1 
ATOM   210  O O   . VAL A 1 30  ? -24.924 -12.176 -38.686 1.00  40.84 ? 30   VAL A O   1 
ATOM   211  C CB  . VAL A 1 30  ? -22.333 -10.404 -38.162 1.00  39.61 ? 30   VAL A CB  1 
ATOM   212  C CG1 . VAL A 1 30  ? -23.601 -9.507  -38.078 1.00  39.47 ? 30   VAL A CG1 1 
ATOM   213  C CG2 . VAL A 1 30  ? -21.833 -10.727 -36.751 1.00  39.46 ? 30   VAL A CG2 1 
ATOM   214  N N   . VAL A 1 31  ? -23.528 -13.427 -37.468 1.00  42.32 ? 31   VAL A N   1 
ATOM   215  C CA  . VAL A 1 31  ? -24.583 -14.090 -36.679 1.00  44.06 ? 31   VAL A CA  1 
ATOM   216  C C   . VAL A 1 31  ? -24.665 -13.448 -35.298 1.00  45.22 ? 31   VAL A C   1 
ATOM   217  O O   . VAL A 1 31  ? -23.778 -13.698 -34.490 1.00  45.89 ? 31   VAL A O   1 
ATOM   218  C CB  . VAL A 1 31  ? -24.280 -15.602 -36.448 1.00  44.11 ? 31   VAL A CB  1 
ATOM   219  C CG1 . VAL A 1 31  ? -25.447 -16.283 -35.714 1.00  44.57 ? 31   VAL A CG1 1 
ATOM   220  C CG2 . VAL A 1 31  ? -23.966 -16.339 -37.775 1.00  44.35 ? 31   VAL A CG2 1 
ATOM   221  N N   . THR A 1 32  ? -25.712 -12.652 -35.027 1.00  46.55 ? 32   THR A N   1 
ATOM   222  C CA  . THR A 1 32  ? -25.846 -11.883 -33.766 1.00  47.55 ? 32   THR A CA  1 
ATOM   223  C C   . THR A 1 32  ? -27.128 -12.196 -32.986 1.00  48.13 ? 32   THR A C   1 
ATOM   224  O O   . THR A 1 32  ? -28.248 -11.938 -33.478 1.00  48.77 ? 32   THR A O   1 
ATOM   225  C CB  . THR A 1 32  ? -25.871 -10.361 -34.038 1.00  47.76 ? 32   THR A CB  1 
ATOM   226  O OG1 . THR A 1 32  ? -26.915 -10.050 -34.983 1.00  47.98 ? 32   THR A OG1 1 
ATOM   227  C CG2 . THR A 1 32  ? -24.542 -9.881  -34.570 1.00  48.58 ? 32   THR A CG2 1 
ATOM   228  N N   . LYS A 1 33  ? -26.985 -12.693 -31.761 0.010 48.35 ? 33   LYS A N   1 
ATOM   229  C CA  . LYS A 1 33  ? -28.152 -13.040 -30.954 0.010 48.57 ? 33   LYS A CA  1 
ATOM   230  C C   . LYS A 1 33  ? -27.908 -12.928 -29.452 0.010 48.84 ? 33   LYS A C   1 
ATOM   231  O O   . LYS A 1 33  ? -26.796 -12.626 -29.011 0.010 48.84 ? 33   LYS A O   1 
ATOM   232  C CB  . LYS A 1 33  ? -28.619 -14.457 -31.298 0.010 48.52 ? 33   LYS A CB  1 
ATOM   233  C CG  . LYS A 1 33  ? -27.486 -15.466 -31.396 0.010 48.43 ? 33   LYS A CG  1 
ATOM   234  C CD  . LYS A 1 33  ? -28.011 -16.890 -31.324 0.010 48.28 ? 33   LYS A CD  1 
ATOM   235  C CE  . LYS A 1 33  ? -26.917 -17.903 -31.629 0.010 48.21 ? 33   LYS A CE  1 
ATOM   236  N NZ  . LYS A 1 33  ? -26.602 -17.965 -33.084 0.010 48.16 ? 33   LYS A NZ  1 
ATOM   237  N N   . LYS A 1 34  ? -28.969 -13.159 -28.682 1.00  49.27 ? 34   LYS A N   1 
ATOM   238  C CA  . LYS A 1 34  ? -28.883 -13.340 -27.238 1.00  49.75 ? 34   LYS A CA  1 
ATOM   239  C C   . LYS A 1 34  ? -29.189 -14.805 -26.882 1.00  49.72 ? 34   LYS A C   1 
ATOM   240  O O   . LYS A 1 34  ? -30.168 -15.367 -27.390 1.00  50.00 ? 34   LYS A O   1 
ATOM   241  C CB  . LYS A 1 34  ? -29.903 -12.446 -26.526 1.00  49.92 ? 34   LYS A CB  1 
ATOM   242  C CG  . LYS A 1 34  ? -29.850 -10.952 -26.875 1.00  51.45 ? 34   LYS A CG  1 
ATOM   243  C CD  . LYS A 1 34  ? -30.096 -10.059 -25.625 1.00  53.40 ? 34   LYS A CD  1 
ATOM   244  C CE  . LYS A 1 34  ? -31.518 -10.180 -25.060 1.00  54.39 ? 34   LYS A CE  1 
ATOM   245  N NZ  . LYS A 1 34  ? -31.523 -10.080 -23.551 1.00  55.28 ? 34   LYS A NZ  1 
ATOM   246  N N   . PHE A 1 35  ? -28.378 -15.418 -26.017 1.00  49.55 ? 35   PHE A N   1 
ATOM   247  C CA  . PHE A 1 35  ? -28.752 -16.714 -25.415 1.00  49.74 ? 35   PHE A CA  1 
ATOM   248  C C   . PHE A 1 35  ? -29.922 -16.572 -24.439 1.00  49.56 ? 35   PHE A C   1 
ATOM   249  O O   . PHE A 1 35  ? -30.171 -15.484 -23.895 1.00  49.49 ? 35   PHE A O   1 
ATOM   250  C CB  . PHE A 1 35  ? -27.588 -17.374 -24.668 1.00  49.92 ? 35   PHE A CB  1 
ATOM   251  C CG  . PHE A 1 35  ? -26.447 -17.796 -25.545 1.00  51.40 ? 35   PHE A CG  1 
ATOM   252  C CD1 . PHE A 1 35  ? -25.143 -17.779 -25.047 1.00  52.71 ? 35   PHE A CD1 1 
ATOM   253  C CD2 . PHE A 1 35  ? -26.665 -18.216 -26.856 1.00  52.53 ? 35   PHE A CD2 1 
ATOM   254  C CE1 . PHE A 1 35  ? -24.072 -18.167 -25.837 1.00  54.11 ? 35   PHE A CE1 1 
ATOM   255  C CE2 . PHE A 1 35  ? -25.604 -18.595 -27.659 1.00  54.08 ? 35   PHE A CE2 1 
ATOM   256  C CZ  . PHE A 1 35  ? -24.301 -18.572 -27.148 1.00  54.92 ? 35   PHE A CZ  1 
ATOM   257  N N   . SER A 1 36  ? -30.617 -17.685 -24.206 0.010 49.56 ? 36   SER A N   1 
ATOM   258  C CA  . SER A 1 36  ? -31.741 -17.748 -23.271 0.010 49.62 ? 36   SER A CA  1 
ATOM   259  C C   . SER A 1 36  ? -31.421 -17.097 -21.926 0.010 49.76 ? 36   SER A C   1 
ATOM   260  O O   . SER A 1 36  ? -32.297 -16.519 -21.282 0.010 49.74 ? 36   SER A O   1 
ATOM   261  C CB  . SER A 1 36  ? -32.173 -19.201 -23.059 0.010 49.57 ? 36   SER A CB  1 
ATOM   262  O OG  . SER A 1 36  ? -33.226 -19.287 -22.116 0.010 49.55 ? 36   SER A OG  1 
ATOM   263  N N   . ASN A 1 37  ? -30.160 -17.190 -21.511 0.50  50.07 ? 37   ASN A N   1 
ATOM   264  C CA  . ASN A 1 37  ? -29.709 -16.575 -20.269 0.50  50.35 ? 37   ASN A CA  1 
ATOM   265  C C   . ASN A 1 37  ? -29.012 -15.223 -20.468 0.50  50.52 ? 37   ASN A C   1 
ATOM   266  O O   . ASN A 1 37  ? -28.051 -14.897 -19.758 0.50  50.34 ? 37   ASN A O   1 
ATOM   267  C CB  . ASN A 1 37  ? -28.789 -17.527 -19.509 0.50  50.38 ? 37   ASN A CB  1 
ATOM   268  C CG  . ASN A 1 37  ? -27.398 -17.575 -20.089 0.50  50.83 ? 37   ASN A CG  1 
ATOM   269  O OD1 . ASN A 1 37  ? -27.198 -18.037 -21.212 0.50  52.16 ? 37   ASN A OD1 1 
ATOM   270  N ND2 . ASN A 1 37  ? -26.422 -17.095 -19.326 0.50  50.74 ? 37   ASN A ND2 1 
ATOM   271  N N   . GLN A 1 38  ? -29.506 -14.456 -21.445 1.00  50.77 ? 38   GLN A N   1 
ATOM   272  C CA  . GLN A 1 38  ? -29.155 -13.036 -21.672 1.00  51.02 ? 38   GLN A CA  1 
ATOM   273  C C   . GLN A 1 38  ? -27.762 -12.649 -22.262 1.00  50.84 ? 38   GLN A C   1 
ATOM   274  O O   . GLN A 1 38  ? -27.547 -11.468 -22.582 1.00  50.97 ? 38   GLN A O   1 
ATOM   275  C CB  . GLN A 1 38  ? -29.302 -12.210 -20.373 1.00  50.78 ? 38   GLN A CB  1 
ATOM   276  C CG  . GLN A 1 38  ? -30.518 -12.608 -19.487 1.00  53.14 ? 38   GLN A CG  1 
ATOM   277  C CD  . GLN A 1 38  ? -31.904 -12.202 -20.057 1.00  55.99 ? 38   GLN A CD  1 
ATOM   278  O OE1 . GLN A 1 38  ? -32.396 -12.791 -21.040 1.00  56.99 ? 38   GLN A OE1 1 
ATOM   279  N NE2 . GLN A 1 38  ? -32.544 -11.213 -19.412 1.00  54.93 ? 38   GLN A NE2 1 
ATOM   280  N N   . GLU A 1 39  ? -26.859 -13.627 -22.434 1.00  50.36 ? 39   GLU A N   1 
ATOM   281  C CA  . GLU A 1 39  ? -25.493 -13.394 -22.958 1.00  49.93 ? 39   GLU A CA  1 
ATOM   282  C C   . GLU A 1 39  ? -25.518 -13.137 -24.459 1.00  49.57 ? 39   GLU A C   1 
ATOM   283  O O   . GLU A 1 39  ? -26.065 -13.941 -25.219 1.00  49.21 ? 39   GLU A O   1 
ATOM   284  C CB  . GLU A 1 39  ? -24.583 -14.602 -22.750 1.00  50.06 ? 39   GLU A CB  1 
ATOM   285  C CG  . GLU A 1 39  ? -24.328 -15.025 -21.337 1.00  50.43 ? 39   GLU A CG  1 
ATOM   286  C CD  . GLU A 1 39  ? -23.136 -15.945 -21.252 1.00  51.51 ? 39   GLU A CD  1 
ATOM   287  O OE1 . GLU A 1 39  ? -22.368 -15.997 -22.244 1.00  51.34 ? 39   GLU A OE1 1 
ATOM   288  O OE2 . GLU A 1 39  ? -22.961 -16.605 -20.199 1.00  52.82 ? 39   GLU A OE2 1 
ATOM   289  N N   . THR A 1 40  ? -24.880 -12.048 -24.884 1.00  49.34 ? 40   THR A N   1 
ATOM   290  C CA  . THR A 1 40  ? -24.708 -11.747 -26.312 1.00  49.08 ? 40   THR A CA  1 
ATOM   291  C C   . THR A 1 40  ? -23.717 -12.685 -27.002 1.00  49.05 ? 40   THR A C   1 
ATOM   292  O O   . THR A 1 40  ? -22.578 -12.877 -26.536 1.00  48.74 ? 40   THR A O   1 
ATOM   293  C CB  . THR A 1 40  ? -24.200 -10.325 -26.564 1.00  49.00 ? 40   THR A CB  1 
ATOM   294  O OG1 . THR A 1 40  ? -24.990 -9.380  -25.830 1.00  49.83 ? 40   THR A OG1 1 
ATOM   295  C CG2 . THR A 1 40  ? -24.278 -10.019 -28.050 1.00  48.92 ? 40   THR A CG2 1 
ATOM   296  N N   . CYS A 1 41  ? -24.161 -13.216 -28.144 0.89  48.92 ? 41   CYS A N   1 
ATOM   297  C CA  . CYS A 1 41  ? -23.417 -14.187 -28.938 0.89  48.82 ? 41   CYS A CA  1 
ATOM   298  C C   . CYS A 1 41  ? -23.297 -13.656 -30.362 0.89  47.58 ? 41   CYS A C   1 
ATOM   299  O O   . CYS A 1 41  ? -24.301 -13.461 -31.061 0.89  47.70 ? 41   CYS A O   1 
ATOM   300  C CB  . CYS A 1 41  ? -24.141 -15.549 -28.902 0.89  49.38 ? 41   CYS A CB  1 
ATOM   301  S SG  . CYS A 1 41  ? -23.735 -16.754 -30.247 0.89  54.40 ? 41   CYS A SG  1 
ATOM   302  N N   . VAL A 1 42  ? -22.055 -13.409 -30.768 1.00  46.45 ? 42   VAL A N   1 
ATOM   303  C CA  . VAL A 1 42  ? -21.721 -12.866 -32.085 1.00  45.20 ? 42   VAL A CA  1 
ATOM   304  C C   . VAL A 1 42  ? -20.609 -13.691 -32.699 1.00  44.50 ? 42   VAL A C   1 
ATOM   305  O O   . VAL A 1 42  ? -19.758 -14.254 -31.984 1.00  44.57 ? 42   VAL A O   1 
ATOM   306  C CB  . VAL A 1 42  ? -21.201 -11.412 -31.991 1.00  45.41 ? 42   VAL A CB  1 
ATOM   307  C CG1 . VAL A 1 42  ? -20.319 -11.050 -33.202 1.00  45.13 ? 42   VAL A CG1 1 
ATOM   308  C CG2 . VAL A 1 42  ? -22.350 -10.433 -31.843 1.00  45.48 ? 42   VAL A CG2 1 
ATOM   309  N N   . THR A 1 43  ? -20.605 -13.734 -34.029 0.40  43.21 ? 43   THR A N   1 
ATOM   310  C CA  . THR A 1 43  ? -19.577 -14.431 -34.764 0.40  42.11 ? 43   THR A CA  1 
ATOM   311  C C   . THR A 1 43  ? -19.597 -13.929 -36.201 0.40  41.35 ? 43   THR A C   1 
ATOM   312  O O   . THR A 1 43  ? -20.644 -13.894 -36.852 0.40  41.23 ? 43   THR A O   1 
ATOM   313  C CB  . THR A 1 43  ? -19.792 -15.948 -34.691 1.00  42.13 ? 43   THR A CB  1 
ATOM   314  O OG1 . THR A 1 43  ? -19.548 -16.397 -33.350 1.00  42.04 ? 43   THR A OG1 1 
ATOM   315  C CG2 . THR A 1 43  ? -18.858 -16.690 -35.652 1.00  42.73 ? 43   THR A CG2 1 
ATOM   316  N N   . ILE A 1 44  ? -18.423 -13.536 -36.681 1.00  40.50 ? 44   ILE A N   1 
ATOM   317  C CA  . ILE A 1 44  ? -18.285 -12.903 -37.982 1.00  39.49 ? 44   ILE A CA  1 
ATOM   318  C C   . ILE A 1 44  ? -18.378 -13.956 -39.073 1.00  39.06 ? 44   ILE A C   1 
ATOM   319  O O   . ILE A 1 44  ? -17.680 -14.975 -39.026 1.00  39.16 ? 44   ILE A O   1 
ATOM   320  C CB  . ILE A 1 44  ? -16.946 -12.133 -38.093 1.00  39.22 ? 44   ILE A CB  1 
ATOM   321  C CG1 . ILE A 1 44  ? -16.716 -11.288 -36.843 1.00  38.85 ? 44   ILE A CG1 1 
ATOM   322  C CG2 . ILE A 1 44  ? -16.942 -11.239 -39.316 1.00  38.69 ? 44   ILE A CG2 1 
ATOM   323  C CD1 . ILE A 1 44  ? -17.685 -10.111 -36.687 1.00  39.90 ? 44   ILE A CD1 1 
ATOM   324  N N   . GLY A 1 45  ? -19.230 -13.691 -40.063 1.00  38.40 ? 45   GLY A N   1 
ATOM   325  C CA  . GLY A 1 45  ? -19.567 -14.676 -41.084 1.00  37.13 ? 45   GLY A CA  1 
ATOM   326  C C   . GLY A 1 45  ? -18.674 -14.590 -42.296 1.00  36.60 ? 45   GLY A C   1 
ATOM   327  O O   . GLY A 1 45  ? -18.993 -15.135 -43.349 1.00  36.87 ? 45   GLY A O   1 
ATOM   328  N N   . GLU A 1 46  ? -17.551 -13.896 -42.160 0.88  35.78 ? 46   GLU A N   1 
ATOM   329  C CA  . GLU A 1 46  ? -16.589 -13.767 -43.252 0.88  34.59 ? 46   GLU A CA  1 
ATOM   330  C C   . GLU A 1 46  ? -15.202 -13.342 -42.778 0.88  34.04 ? 46   GLU A C   1 
ATOM   331  O O   . GLU A 1 46  ? -15.035 -12.829 -41.671 0.88  33.78 ? 46   GLU A O   1 
ATOM   332  C CB  . GLU A 1 46  ? -17.089 -12.799 -44.321 0.88  34.60 ? 46   GLU A CB  1 
ATOM   333  C CG  . GLU A 1 46  ? -17.541 -11.410 -43.832 0.88  35.04 ? 46   GLU A CG  1 
ATOM   334  C CD  . GLU A 1 46  ? -18.098 -10.566 -44.987 0.88  35.96 ? 46   GLU A CD  1 
ATOM   335  O OE1 . GLU A 1 46  ? -17.375 -10.388 -45.989 0.88  35.68 ? 46   GLU A OE1 1 
ATOM   336  O OE2 . GLU A 1 46  ? -19.261 -10.106 -44.918 0.88  35.55 ? 46   GLU A OE2 1 
ATOM   337  N N   . SER A 1 47  ? -14.214 -13.560 -43.644 1.00  33.30 ? 47   SER A N   1 
ATOM   338  C CA  . SER A 1 47  ? -12.834 -13.178 -43.385 1.00  32.61 ? 47   SER A CA  1 
ATOM   339  C C   . SER A 1 47  ? -12.663 -11.661 -43.460 1.00  32.26 ? 47   SER A C   1 
ATOM   340  O O   . SER A 1 47  ? -12.983 -11.048 -44.485 1.00  32.34 ? 47   SER A O   1 
ATOM   341  C CB  . SER A 1 47  ? -11.902 -13.853 -44.401 1.00  32.76 ? 47   SER A CB  1 
ATOM   342  O OG  . SER A 1 47  ? -10.579 -13.320 -44.370 1.00  32.48 ? 47   SER A OG  1 
ATOM   343  N N   . VAL A 1 48  ? -12.134 -11.079 -42.385 1.00  31.28 ? 48   VAL A N   1 
ATOM   344  C CA  . VAL A 1 48  ? -11.933 -9.642  -42.285 1.00  30.40 ? 48   VAL A CA  1 
ATOM   345  C C   . VAL A 1 48  ? -10.450 -9.283  -42.270 1.00  29.96 ? 48   VAL A C   1 
ATOM   346  O O   . VAL A 1 48  ? -10.069 -8.141  -41.939 1.00  29.97 ? 48   VAL A O   1 
ATOM   347  C CB  . VAL A 1 48  ? -12.594 -9.077  -40.997 1.00  30.66 ? 48   VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 48  ? -14.092 -9.281  -41.039 1.00  30.91 ? 48   VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 48  ? -11.995 -9.727  -39.751 1.00  29.54 ? 48   VAL A CG2 1 
ATOM   350  N N   . ARG A 1 49  ? -9.620  -10.269 -42.616 1.00  29.26 ? 49   ARG A N   1 
ATOM   351  C CA  . ARG A 1 49  ? -8.155  -10.157 -42.554 1.00  28.36 ? 49   ARG A CA  1 
ATOM   352  C C   . ARG A 1 49  ? -7.622  -9.048  -43.440 1.00  28.42 ? 49   ARG A C   1 
ATOM   353  O O   . ARG A 1 49  ? -7.852  -9.051  -44.650 1.00  28.19 ? 49   ARG A O   1 
ATOM   354  C CB  . ARG A 1 49  ? -7.560  -11.465 -43.021 1.00  28.15 ? 49   ARG A CB  1 
ATOM   355  C CG  . ARG A 1 49  ? -6.154  -11.701 -42.613 1.00  27.04 ? 49   ARG A CG  1 
ATOM   356  C CD  . ARG A 1 49  ? -5.804  -13.162 -42.842 1.00  25.45 ? 49   ARG A CD  1 
ATOM   357  N NE  . ARG A 1 49  ? -6.472  -14.089 -41.925 1.00  23.43 ? 49   ARG A NE  1 
ATOM   358  C CZ  . ARG A 1 49  ? -6.072  -14.339 -40.684 1.00  22.41 ? 49   ARG A CZ  1 
ATOM   359  N NH1 . ARG A 1 49  ? -5.019  -13.714 -40.172 1.00  21.38 ? 49   ARG A NH1 1 
ATOM   360  N NH2 . ARG A 1 49  ? -6.736  -15.212 -39.950 1.00  23.28 ? 49   ARG A NH2 1 
ATOM   361  N N   . GLY A 1 50  ? -6.924  -8.088  -42.837 1.00  28.53 ? 50   GLY A N   1 
ATOM   362  C CA  . GLY A 1 50  ? -6.320  -6.987  -43.594 1.00  29.01 ? 50   GLY A CA  1 
ATOM   363  C C   . GLY A 1 50  ? -7.342  -5.994  -44.138 1.00  29.55 ? 50   GLY A C   1 
ATOM   364  O O   . GLY A 1 50  ? -7.053  -5.218  -45.056 1.00  29.85 ? 50   GLY A O   1 
ATOM   365  N N   . GLU A 1 51  ? -8.532  -5.997  -43.545 1.00  29.72 ? 51   GLU A N   1 
ATOM   366  C CA  . GLU A 1 51  ? -9.623  -5.129  -43.960 1.00  29.68 ? 51   GLU A CA  1 
ATOM   367  C C   . GLU A 1 51  ? -9.912  -3.971  -42.990 1.00  29.19 ? 51   GLU A C   1 
ATOM   368  O O   . GLU A 1 51  ? -9.845  -4.131  -41.771 1.00  29.47 ? 51   GLU A O   1 
ATOM   369  C CB  . GLU A 1 51  ? -10.873 -5.976  -44.212 1.00  29.82 ? 51   GLU A CB  1 
ATOM   370  C CG  . GLU A 1 51  ? -10.686 -6.987  -45.349 1.00  32.36 ? 51   GLU A CG  1 
ATOM   371  C CD  . GLU A 1 51  ? -11.989 -7.606  -45.842 1.00  35.94 ? 51   GLU A CD  1 
ATOM   372  O OE1 . GLU A 1 51  ? -12.902 -7.850  -45.013 1.00  39.10 ? 51   GLU A OE1 1 
ATOM   373  O OE2 . GLU A 1 51  ? -12.103 -7.876  -47.069 1.00  37.73 ? 51   GLU A OE2 1 
ATOM   374  N N   . ASP A 1 52  ? -10.208 -2.806  -43.568 1.00  28.72 ? 52   ASP A N   1 
ATOM   375  C CA  . ASP A 1 52  ? -10.563 -1.563  -42.876 1.00  28.10 ? 52   ASP A CA  1 
ATOM   376  C C   . ASP A 1 52  ? -12.006 -1.755  -42.483 1.00  27.72 ? 52   ASP A C   1 
ATOM   377  O O   . ASP A 1 52  ? -12.875 -1.720  -43.337 1.00  27.47 ? 52   ASP A O   1 
ATOM   378  C CB  . ASP A 1 52  ? -10.422 -0.401  -43.892 1.00  28.25 ? 52   ASP A CB  1 
ATOM   379  C CG  . ASP A 1 52  ? -10.547 1.006   -43.272 1.00  28.56 ? 52   ASP A CG  1 
ATOM   380  O OD1 . ASP A 1 52  ? -10.013 1.240   -42.148 1.00  31.04 ? 52   ASP A OD1 1 
ATOM   381  O OD2 . ASP A 1 52  ? -11.127 1.905   -43.958 1.00  24.87 ? 52   ASP A OD2 1 
ATOM   382  N N   . VAL A 1 53  ? -12.268 -1.968  -41.192 1.00  27.69 ? 53   VAL A N   1 
ATOM   383  C CA  . VAL A 1 53  ? -13.579 -2.468  -40.741 1.00  26.78 ? 53   VAL A CA  1 
ATOM   384  C C   . VAL A 1 53  ? -14.398 -1.474  -39.945 1.00  26.46 ? 53   VAL A C   1 
ATOM   385  O O   . VAL A 1 53  ? -13.934 -0.954  -38.924 1.00  26.43 ? 53   VAL A O   1 
ATOM   386  C CB  . VAL A 1 53  ? -13.422 -3.751  -39.939 1.00  26.48 ? 53   VAL A CB  1 
ATOM   387  C CG1 . VAL A 1 53  ? -14.752 -4.168  -39.296 1.00  26.58 ? 53   VAL A CG1 1 
ATOM   388  C CG2 . VAL A 1 53  ? -12.914 -4.834  -40.849 1.00  27.16 ? 53   VAL A CG2 1 
ATOM   389  N N   . TYR A 1 54  ? -15.621 -1.228  -40.417 1.00  25.93 ? 54   TYR A N   1 
ATOM   390  C CA  . TYR A 1 54  ? -16.554 -0.323  -39.747 1.00  25.95 ? 54   TYR A CA  1 
ATOM   391  C C   . TYR A 1 54  ? -17.739 -1.044  -39.084 1.00  26.63 ? 54   TYR A C   1 
ATOM   392  O O   . TYR A 1 54  ? -18.469 -1.791  -39.720 1.00  26.21 ? 54   TYR A O   1 
ATOM   393  C CB  . TYR A 1 54  ? -17.028 0.765   -40.715 1.00  25.22 ? 54   TYR A CB  1 
ATOM   394  C CG  . TYR A 1 54  ? -15.885 1.626   -41.202 1.00  23.16 ? 54   TYR A CG  1 
ATOM   395  C CD1 . TYR A 1 54  ? -14.952 1.132   -42.117 1.00  19.62 ? 54   TYR A CD1 1 
ATOM   396  C CD2 . TYR A 1 54  ? -15.709 2.918   -40.722 1.00  21.56 ? 54   TYR A CD2 1 
ATOM   397  C CE1 . TYR A 1 54  ? -13.902 1.889   -42.546 1.00  17.69 ? 54   TYR A CE1 1 
ATOM   398  C CE2 . TYR A 1 54  ? -14.639 3.689   -41.162 1.00  20.89 ? 54   TYR A CE2 1 
ATOM   399  C CZ  . TYR A 1 54  ? -13.742 3.161   -42.077 1.00  18.02 ? 54   TYR A CZ  1 
ATOM   400  O OH  . TYR A 1 54  ? -12.687 3.918   -42.523 1.00  17.31 ? 54   TYR A OH  1 
ATOM   401  N N   . ILE A 1 55  ? -17.898 -0.826  -37.782 1.00  27.60 ? 55   ILE A N   1 
ATOM   402  C CA  . ILE A 1 55  ? -19.028 -1.375  -37.037 1.00  28.43 ? 55   ILE A CA  1 
ATOM   403  C C   . ILE A 1 55  ? -19.971 -0.252  -36.588 1.00  29.06 ? 55   ILE A C   1 
ATOM   404  O O   . ILE A 1 55  ? -19.633 0.532   -35.714 1.00  28.99 ? 55   ILE A O   1 
ATOM   405  C CB  . ILE A 1 55  ? -18.553 -2.201  -35.835 1.00  28.18 ? 55   ILE A CB  1 
ATOM   406  C CG1 . ILE A 1 55  ? -17.753 -3.410  -36.319 1.00  28.26 ? 55   ILE A CG1 1 
ATOM   407  C CG2 . ILE A 1 55  ? -19.735 -2.663  -34.998 1.00  27.86 ? 55   ILE A CG2 1 
ATOM   408  C CD1 . ILE A 1 55  ? -16.721 -3.893  -35.340 1.00  29.19 ? 55   ILE A CD1 1 
ATOM   409  N N   . VAL A 1 56  ? -21.141 -0.166  -37.213 1.00  30.05 ? 56   VAL A N   1 
ATOM   410  C CA  . VAL A 1 56  ? -22.076 0.909   -36.927 1.00  31.15 ? 56   VAL A CA  1 
ATOM   411  C C   . VAL A 1 56  ? -23.000 0.485   -35.806 1.00  32.83 ? 56   VAL A C   1 
ATOM   412  O O   . VAL A 1 56  ? -23.848 -0.407  -35.983 1.00  32.75 ? 56   VAL A O   1 
ATOM   413  C CB  . VAL A 1 56  ? -22.922 1.324   -38.152 1.00  30.77 ? 56   VAL A CB  1 
ATOM   414  C CG1 . VAL A 1 56  ? -23.818 2.476   -37.798 1.00  30.61 ? 56   VAL A CG1 1 
ATOM   415  C CG2 . VAL A 1 56  ? -22.062 1.724   -39.313 1.00  30.36 ? 56   VAL A CG2 1 
ATOM   416  N N   . GLN A 1 57  ? -22.830 1.148   -34.661 1.00  34.83 ? 57   GLN A N   1 
ATOM   417  C CA  . GLN A 1 57  ? -23.584 0.871   -33.447 1.00  36.90 ? 57   GLN A CA  1 
ATOM   418  C C   . GLN A 1 57  ? -25.078 0.736   -33.700 1.00  37.16 ? 57   GLN A C   1 
ATOM   419  O O   . GLN A 1 57  ? -25.653 1.490   -34.501 1.00  37.18 ? 57   GLN A O   1 
ATOM   420  C CB  . GLN A 1 57  ? -23.296 1.938   -32.379 1.00  37.99 ? 57   GLN A CB  1 
ATOM   421  C CG  . GLN A 1 57  ? -24.532 2.525   -31.656 1.00  41.54 ? 57   GLN A CG  1 
ATOM   422  C CD  . GLN A 1 57  ? -25.093 3.758   -32.383 1.00  46.86 ? 57   GLN A CD  1 
ATOM   423  O OE1 . GLN A 1 57  ? -24.892 4.903   -31.924 1.00  49.07 ? 57   GLN A OE1 1 
ATOM   424  N NE2 . GLN A 1 57  ? -25.770 3.538   -33.527 1.00  45.52 ? 57   GLN A NE2 1 
ATOM   425  N N   . SER A 1 58  ? -25.678 -0.218  -32.979 0.10  37.20 ? 58   SER A N   1 
ATOM   426  C CA  . SER A 1 58  ? -27.076 -0.636  -33.124 0.10  37.23 ? 58   SER A CA  1 
ATOM   427  C C   . SER A 1 58  ? -28.044 0.078   -32.188 0.10  37.19 ? 58   SER A C   1 
ATOM   428  O O   . SER A 1 58  ? -27.637 0.713   -31.213 0.10  37.16 ? 58   SER A O   1 
ATOM   429  C CB  . SER A 1 58  ? -27.280 -1.979  -32.423 0.10  37.23 ? 58   SER A CB  1 
ATOM   430  N N   . GLY A 1 59  ? -29.304 0.000   -32.591 0.010 37.19 ? 59   GLY A N   1 
ATOM   431  C CA  . GLY A 1 59  ? -30.447 0.516   -31.872 0.010 37.17 ? 59   GLY A CA  1 
ATOM   432  C C   . GLY A 1 59  ? -31.598 -0.039  -31.035 0.010 37.15 ? 59   GLY A C   1 
ATOM   433  O O   . GLY A 1 59  ? -32.639 0.590   -30.808 0.010 37.16 ? 59   GLY A O   1 
ATOM   434  N N   . CYS A 1 60  ? -31.398 -1.264  -30.594 0.010 37.08 ? 60   CYS A N   1 
ATOM   435  C CA  . CYS A 1 60  ? -32.451 -1.986  -29.934 0.010 37.00 ? 60   CYS A CA  1 
ATOM   436  C C   . CYS A 1 60  ? -32.552 -1.550  -28.504 0.010 36.91 ? 60   CYS A C   1 
ATOM   437  O O   . CYS A 1 60  ? -32.700 -2.360  -27.595 0.010 36.92 ? 60   CYS A O   1 
ATOM   438  C CB  . CYS A 1 60  ? -32.214 -3.480  -30.059 0.010 37.02 ? 60   CYS A CB  1 
ATOM   439  S SG  . CYS A 1 60  ? -33.325 -4.246  -31.257 0.010 37.03 ? 60   CYS A SG  1 
ATOM   440  N N   . GLY A 1 61  ? -32.408 -0.236  -28.347 0.010 36.78 ? 61   GLY A N   1 
ATOM   441  C CA  . GLY A 1 61  ? -32.886 0.516   -27.193 0.010 36.60 ? 61   GLY A CA  1 
ATOM   442  C C   . GLY A 1 61  ? -31.931 0.169   -26.069 0.010 36.45 ? 61   GLY A C   1 
ATOM   443  O O   . GLY A 1 61  ? -31.255 1.042   -25.526 0.010 36.45 ? 61   GLY A O   1 
ATOM   444  N N   . GLU A 1 62  ? -31.772 -1.109  -25.791 0.10  36.28 ? 62   GLU A N   1 
ATOM   445  C CA  . GLU A 1 62  ? -31.114 -1.593  -24.587 0.10  36.11 ? 62   GLU A CA  1 
ATOM   446  C C   . GLU A 1 62  ? -29.628 -1.281  -24.779 0.10  36.11 ? 62   GLU A C   1 
ATOM   447  O O   . GLU A 1 62  ? -28.926 -1.950  -25.537 0.10  36.08 ? 62   GLU A O   1 
ATOM   448  C CB  . GLU A 1 62  ? -31.341 -3.088  -24.363 0.10  36.07 ? 62   GLU A CB  1 
ATOM   449  C CG  . GLU A 1 62  ? -31.705 -3.455  -22.933 0.10  35.62 ? 62   GLU A CG  1 
ATOM   450  C CD  . GLU A 1 62  ? -30.562 -3.253  -21.961 0.10  35.00 ? 62   GLU A CD  1 
ATOM   451  O OE1 . GLU A 1 62  ? -29.403 -3.151  -22.411 0.10  34.80 ? 62   GLU A OE1 1 
ATOM   452  O OE2 . GLU A 1 62  ? -30.828 -3.199  -20.744 0.10  34.71 ? 62   GLU A OE2 1 
ATOM   453  N N   . ILE A 1 63  ? -29.179 -0.253  -24.068 1.00  36.15 ? 63   ILE A N   1 
ATOM   454  C CA  . ILE A 1 63  ? -27.829 0.337   -24.177 1.00  36.14 ? 63   ILE A CA  1 
ATOM   455  C C   . ILE A 1 63  ? -26.674 -0.558  -23.696 1.00  36.06 ? 63   ILE A C   1 
ATOM   456  O O   . ILE A 1 63  ? -25.619 -0.611  -24.332 1.00  35.98 ? 63   ILE A O   1 
ATOM   457  C CB  . ILE A 1 63  ? -27.743 1.678   -23.389 1.00  36.01 ? 63   ILE A CB  1 
ATOM   458  C CG1 . ILE A 1 63  ? -26.495 2.450   -23.788 1.00  35.80 ? 63   ILE A CG1 1 
ATOM   459  C CG2 . ILE A 1 63  ? -27.737 1.417   -21.871 1.00  35.47 ? 63   ILE A CG2 1 
ATOM   460  C CD1 . ILE A 1 63  ? -26.367 3.794   -23.102 1.00  36.36 ? 63   ILE A CD1 1 
ATOM   461  N N   . ASN A 1 64  ? -26.855 -1.220  -22.555 1.00  35.50 ? 64   ASN A N   1 
ATOM   462  C CA  . ASN A 1 64  ? -25.845 -2.147  -22.081 1.00  34.99 ? 64   ASN A CA  1 
ATOM   463  C C   . ASN A 1 64  ? -25.728 -3.336  -23.040 1.00  34.69 ? 64   ASN A C   1 
ATOM   464  O O   . ASN A 1 64  ? -24.626 -3.813  -23.311 1.00  34.50 ? 64   ASN A O   1 
ATOM   465  C CB  . ASN A 1 64  ? -26.141 -2.582  -20.638 1.00  35.08 ? 64   ASN A CB  1 
ATOM   466  C CG  . ASN A 1 64  ? -26.282 -1.381  -19.673 1.00  35.27 ? 64   ASN A CG  1 
ATOM   467  O OD1 . ASN A 1 64  ? -25.660 -0.337  -19.865 1.00  35.74 ? 64   ASN A OD1 1 
ATOM   468  N ND2 . ASN A 1 64  ? -27.091 -1.543  -18.622 1.00  33.61 ? 64   ASN A ND2 1 
ATOM   469  N N   . ASP A 1 65  ? -26.867 -3.784  -23.571 1.00  34.38 ? 65   ASP A N   1 
ATOM   470  C CA  . ASP A 1 65  ? -26.894 -4.835  -24.591 1.00  34.37 ? 65   ASP A CA  1 
ATOM   471  C C   . ASP A 1 65  ? -26.195 -4.399  -25.891 1.00  33.78 ? 65   ASP A C   1 
ATOM   472  O O   . ASP A 1 65  ? -25.406 -5.151  -26.483 1.00  33.10 ? 65   ASP A O   1 
ATOM   473  C CB  . ASP A 1 65  ? -28.335 -5.253  -24.870 1.00  34.53 ? 65   ASP A CB  1 
ATOM   474  C CG  . ASP A 1 65  ? -28.923 -6.111  -23.756 1.00  36.78 ? 65   ASP A CG  1 
ATOM   475  O OD1 . ASP A 1 65  ? -28.161 -6.693  -22.936 1.00  37.74 ? 65   ASP A OD1 1 
ATOM   476  O OD2 . ASP A 1 65  ? -30.167 -6.221  -23.702 1.00  39.20 ? 65   ASP A OD2 1 
ATOM   477  N N   . ASN A 1 66  ? -26.496 -3.171  -26.306 1.00  33.33 ? 66   ASN A N   1 
ATOM   478  C CA  . ASN A 1 66  ? -25.900 -2.573  -27.482 1.00  33.07 ? 66   ASN A CA  1 
ATOM   479  C C   . ASN A 1 66  ? -24.429 -2.268  -27.322 1.00  32.51 ? 66   ASN A C   1 
ATOM   480  O O   . ASN A 1 66  ? -23.666 -2.447  -28.270 1.00  32.90 ? 66   ASN A O   1 
ATOM   481  C CB  . ASN A 1 66  ? -26.651 -1.306  -27.881 1.00  33.41 ? 66   ASN A CB  1 
ATOM   482  C CG  . ASN A 1 66  ? -27.897 -1.603  -28.684 1.00  34.79 ? 66   ASN A CG  1 
ATOM   483  O OD1 . ASN A 1 66  ? -28.105 -2.732  -29.171 1.00  38.19 ? 66   ASN A OD1 1 
ATOM   484  N ND2 . ASN A 1 66  ? -28.727 -0.585  -28.848 1.00  36.29 ? 66   ASN A ND2 1 
ATOM   485  N N   . LEU A 1 67  ? -24.032 -1.802  -26.140 1.00  31.81 ? 67   LEU A N   1 
ATOM   486  C CA  . LEU A 1 67  ? -22.631 -1.517  -25.881 1.00  31.00 ? 67   LEU A CA  1 
ATOM   487  C C   . LEU A 1 67  ? -21.794 -2.780  -25.920 1.00  30.82 ? 67   LEU A C   1 
ATOM   488  O O   . LEU A 1 67  ? -20.735 -2.787  -26.541 1.00  31.29 ? 67   LEU A O   1 
ATOM   489  C CB  . LEU A 1 67  ? -22.444 -0.803  -24.545 1.00  30.78 ? 67   LEU A CB  1 
ATOM   490  C CG  . LEU A 1 67  ? -21.022 -0.343  -24.205 1.00  30.70 ? 67   LEU A CG  1 
ATOM   491  C CD1 . LEU A 1 67  ? -20.479 0.642   -25.247 1.00  29.67 ? 67   LEU A CD1 1 
ATOM   492  C CD2 . LEU A 1 67  ? -20.993 0.261   -22.808 1.00  29.38 ? 67   LEU A CD2 1 
ATOM   493  N N   . MET A 1 68  ? -22.262 -3.842  -25.268 0.70  30.13 ? 68   MET A N   1 
ATOM   494  C CA  . MET A 1 68  ? -21.498 -5.079  -25.191 0.70  29.40 ? 68   MET A CA  1 
ATOM   495  C C   . MET A 1 68  ? -21.329 -5.735  -26.560 0.70  29.23 ? 68   MET A C   1 
ATOM   496  O O   . MET A 1 68  ? -20.244 -6.214  -26.903 0.70  29.41 ? 68   MET A O   1 
ATOM   497  C CB  . MET A 1 68  ? -22.148 -6.055  -24.219 0.70  29.42 ? 68   MET A CB  1 
ATOM   498  C CG  . MET A 1 68  ? -21.862 -5.770  -22.739 0.70  29.67 ? 68   MET A CG  1 
ATOM   499  S SD  . MET A 1 68  ? -20.094 -6.011  -22.242 0.70  31.51 ? 68   MET A SD  1 
ATOM   500  C CE  . MET A 1 68  ? -19.756 -7.679  -22.837 0.70  27.86 ? 68   MET A CE  1 
ATOM   501  N N   . GLU A 1 69  ? -22.401 -5.750  -27.343 1.00  28.79 ? 69   GLU A N   1 
ATOM   502  C CA  . GLU A 1 69  ? -22.388 -6.368  -28.664 1.00  28.45 ? 69   GLU A CA  1 
ATOM   503  C C   . GLU A 1 69  ? -21.471 -5.567  -29.596 1.00  27.96 ? 69   GLU A C   1 
ATOM   504  O O   . GLU A 1 69  ? -20.897 -6.114  -30.561 1.00  27.75 ? 69   GLU A O   1 
ATOM   505  C CB  . GLU A 1 69  ? -23.817 -6.436  -29.187 1.00  28.54 ? 69   GLU A CB  1 
ATOM   506  C CG  . GLU A 1 69  ? -24.020 -7.156  -30.495 1.00  31.50 ? 69   GLU A CG  1 
ATOM   507  C CD  . GLU A 1 69  ? -25.440 -6.951  -31.042 1.00  35.76 ? 69   GLU A CD  1 
ATOM   508  O OE1 . GLU A 1 69  ? -26.013 -5.844  -30.831 1.00  36.88 ? 69   GLU A OE1 1 
ATOM   509  O OE2 . GLU A 1 69  ? -25.979 -7.897  -31.676 1.00  36.19 ? 69   GLU A OE2 1 
ATOM   510  N N   . LEU A 1 70  ? -21.320 -4.275  -29.284 1.00  27.05 ? 70   LEU A N   1 
ATOM   511  C CA  . LEU A 1 70  ? -20.370 -3.420  -29.980 1.00  26.34 ? 70   LEU A CA  1 
ATOM   512  C C   . LEU A 1 70  ? -18.952 -3.820  -29.638 1.00  26.56 ? 70   LEU A C   1 
ATOM   513  O O   . LEU A 1 70  ? -18.104 -3.923  -30.527 1.00  27.13 ? 70   LEU A O   1 
ATOM   514  C CB  . LEU A 1 70  ? -20.591 -1.964  -29.598 1.00  25.87 ? 70   LEU A CB  1 
ATOM   515  C CG  . LEU A 1 70  ? -19.711 -0.841  -30.150 1.00  24.96 ? 70   LEU A CG  1 
ATOM   516  C CD1 . LEU A 1 70  ? -19.456 -0.928  -31.660 1.00  24.16 ? 70   LEU A CD1 1 
ATOM   517  C CD2 . LEU A 1 70  ? -20.367 0.482   -29.802 1.00  23.24 ? 70   LEU A CD2 1 
ATOM   518  N N   . LEU A 1 71  ? -18.696 -4.034  -28.347 1.00  26.60 ? 71   LEU A N   1 
ATOM   519  C CA  . LEU A 1 71  ? -17.354 -4.338  -27.875 1.00  26.44 ? 71   LEU A CA  1 
ATOM   520  C C   . LEU A 1 71  ? -16.935 -5.709  -28.362 1.00  26.35 ? 71   LEU A C   1 
ATOM   521  O O   . LEU A 1 71  ? -15.773 -5.937  -28.702 1.00  26.17 ? 71   LEU A O   1 
ATOM   522  C CB  . LEU A 1 71  ? -17.297 -4.261  -26.357 1.00  26.26 ? 71   LEU A CB  1 
ATOM   523  C CG  . LEU A 1 71  ? -17.628 -2.908  -25.748 1.00  26.67 ? 71   LEU A CG  1 
ATOM   524  C CD1 . LEU A 1 71  ? -17.526 -3.026  -24.237 1.00  29.19 ? 71   LEU A CD1 1 
ATOM   525  C CD2 . LEU A 1 71  ? -16.685 -1.835  -26.241 1.00  26.92 ? 71   LEU A CD2 1 
ATOM   526  N N   . ILE A 1 72  ? -17.905 -6.607  -28.419 1.00  26.36 ? 72   ILE A N   1 
ATOM   527  C CA  . ILE A 1 72  ? -17.658 -7.976  -28.824 1.00  27.09 ? 72   ILE A CA  1 
ATOM   528  C C   . ILE A 1 72  ? -17.322 -8.034  -30.311 1.00  27.19 ? 72   ILE A C   1 
ATOM   529  O O   . ILE A 1 72  ? -16.372 -8.707  -30.707 1.00  27.14 ? 72   ILE A O   1 
ATOM   530  C CB  . ILE A 1 72  ? -18.857 -8.865  -28.454 1.00  27.43 ? 72   ILE A CB  1 
ATOM   531  C CG1 . ILE A 1 72  ? -18.840 -9.141  -26.946 1.00  27.77 ? 72   ILE A CG1 1 
ATOM   532  C CG2 . ILE A 1 72  ? -18.853 -10.163 -29.230 1.00  27.07 ? 72   ILE A CG2 1 
ATOM   533  C CD1 . ILE A 1 72  ? -20.205 -9.262  -26.352 1.00  29.32 ? 72   ILE A CD1 1 
ATOM   534  N N   . MET A 1 73  ? -18.074 -7.295  -31.125 1.00  27.35 ? 73   MET A N   1 
ATOM   535  C CA  . MET A 1 73  ? -17.736 -7.175  -32.542 1.00  27.12 ? 73   MET A CA  1 
ATOM   536  C C   . MET A 1 73  ? -16.408 -6.507  -32.791 1.00  26.58 ? 73   MET A C   1 
ATOM   537  O O   . MET A 1 73  ? -15.650 -6.950  -33.648 1.00  26.77 ? 73   MET A O   1 
ATOM   538  C CB  . MET A 1 73  ? -18.818 -6.459  -33.317 1.00  27.35 ? 73   MET A CB  1 
ATOM   539  C CG  . MET A 1 73  ? -20.009 -7.334  -33.573 1.00  29.06 ? 73   MET A CG  1 
ATOM   540  S SD  . MET A 1 73  ? -21.070 -6.558  -34.775 1.00  30.62 ? 73   MET A SD  1 
ATOM   541  C CE  . MET A 1 73  ? -20.428 -7.380  -36.235 1.00  34.12 ? 73   MET A CE  1 
ATOM   542  N N   . ILE A 1 74  ? -16.113 -5.440  -32.058 1.00  26.21 ? 74   ILE A N   1 
ATOM   543  C CA  . ILE A 1 74  ? -14.808 -4.784  -32.210 1.00  25.96 ? 74   ILE A CA  1 
ATOM   544  C C   . ILE A 1 74  ? -13.677 -5.767  -31.899 1.00  25.64 ? 74   ILE A C   1 
ATOM   545  O O   . ILE A 1 74  ? -12.715 -5.870  -32.648 1.00  25.62 ? 74   ILE A O   1 
ATOM   546  C CB  . ILE A 1 74  ? -14.674 -3.512  -31.376 1.00  25.79 ? 74   ILE A CB  1 
ATOM   547  C CG1 . ILE A 1 74  ? -15.593 -2.423  -31.938 1.00  25.89 ? 74   ILE A CG1 1 
ATOM   548  C CG2 . ILE A 1 74  ? -13.238 -3.004  -31.474 1.00  25.94 ? 74   ILE A CG2 1 
ATOM   549  C CD1 . ILE A 1 74  ? -15.822 -1.244  -30.983 1.00  24.89 ? 74   ILE A CD1 1 
ATOM   550  N N   . ASN A 1 75  ? -13.826 -6.519  -30.818 1.00  25.66 ? 75   ASN A N   1 
ATOM   551  C CA  . ASN A 1 75  ? -12.884 -7.579  -30.486 1.00  25.74 ? 75   ASN A CA  1 
ATOM   552  C C   . ASN A 1 75  ? -12.818 -8.680  -31.559 1.00  25.99 ? 75   ASN A C   1 
ATOM   553  O O   . ASN A 1 75  ? -11.742 -8.989  -32.119 1.00  26.40 ? 75   ASN A O   1 
ATOM   554  C CB  . ASN A 1 75  ? -13.267 -8.168  -29.138 1.00  25.45 ? 75   ASN A CB  1 
ATOM   555  C CG  . ASN A 1 75  ? -12.157 -8.913  -28.527 1.00  25.26 ? 75   ASN A CG  1 
ATOM   556  O OD1 . ASN A 1 75  ? -12.344 -10.045 -28.092 1.00  29.34 ? 75   ASN A OD1 1 
ATOM   557  N ND2 . ASN A 1 75  ? -10.963 -8.306  -28.508 1.00  25.50 ? 75   ASN A ND2 1 
ATOM   558  N N   . ALA A 1 76  ? -13.983 -9.249  -31.874 1.00  26.28 ? 76   ALA A N   1 
ATOM   559  C CA  . ALA A 1 76  ? -14.070 -10.324 -32.874 1.00  26.75 ? 76   ALA A CA  1 
ATOM   560  C C   . ALA A 1 76  ? -13.147 -9.996  -34.020 1.00  27.39 ? 76   ALA A C   1 
ATOM   561  O O   . ALA A 1 76  ? -12.268 -10.789 -34.388 1.00  27.81 ? 76   ALA A O   1 
ATOM   562  C CB  . ALA A 1 76  ? -15.501 -10.465 -33.397 1.00  26.07 ? 76   ALA A CB  1 
ATOM   563  N N   . CYS A 1 77  ? -13.375 -8.802  -34.566 1.00  28.03 ? 77   CYS A N   1 
ATOM   564  C CA  . CYS A 1 77  ? -12.629 -8.254  -35.678 1.00  28.24 ? 77   CYS A CA  1 
ATOM   565  C C   . CYS A 1 77  ? -11.132 -8.098  -35.402 1.00  28.66 ? 77   CYS A C   1 
ATOM   566  O O   . CYS A 1 77  ? -10.341 -8.341  -36.308 1.00  28.97 ? 77   CYS A O   1 
ATOM   567  C CB  . CYS A 1 77  ? -13.250 -6.912  -36.090 1.00  28.53 ? 77   CYS A CB  1 
ATOM   568  S SG  . CYS A 1 77  ? -14.987 -7.069  -36.805 1.00  29.74 ? 77   CYS A SG  1 
ATOM   569  N N   . LYS A 1 78  ? -10.737 -7.712  -34.179 1.00  29.08 ? 78   LYS A N   1 
ATOM   570  C CA  . LYS A 1 78  ? -9.329  -7.394  -33.908 1.00  29.57 ? 78   LYS A CA  1 
ATOM   571  C C   . LYS A 1 78  ? -8.472  -8.656  -33.864 1.00  30.14 ? 78   LYS A C   1 
ATOM   572  O O   . LYS A 1 78  ? -7.368  -8.679  -34.438 1.00  30.82 ? 78   LYS A O   1 
ATOM   573  C CB  . LYS A 1 78  ? -9.162  -6.571  -32.627 1.00  30.04 ? 78   LYS A CB  1 
ATOM   574  C CG  . LYS A 1 78  ? -7.827  -5.783  -32.487 1.00  30.46 ? 78   LYS A CG  1 
ATOM   575  C CD  . LYS A 1 78  ? -7.901  -4.431  -33.227 1.00  31.79 ? 78   LYS A CD  1 
ATOM   576  C CE  . LYS A 1 78  ? -6.585  -3.618  -33.160 1.00  31.75 ? 78   LYS A CE  1 
ATOM   577  N NZ  . LYS A 1 78  ? -6.367  -2.826  -31.895 1.00  32.43 ? 78   LYS A NZ  1 
ATOM   578  N N   . ILE A 1 79  ? -8.986  -9.710  -33.222 1.00  30.38 ? 79   ILE A N   1 
ATOM   579  C CA  . ILE A 1 79  ? -8.234  -10.962 -33.116 1.00  30.10 ? 79   ILE A CA  1 
ATOM   580  C C   . ILE A 1 79  ? -8.350  -11.817 -34.376 1.00  30.01 ? 79   ILE A C   1 
ATOM   581  O O   . ILE A 1 79  ? -7.703  -12.856 -34.482 1.00  30.29 ? 79   ILE A O   1 
ATOM   582  C CB  . ILE A 1 79  ? -8.592  -11.763 -31.825 1.00  29.99 ? 79   ILE A CB  1 
ATOM   583  C CG1 . ILE A 1 79  ? -10.095 -11.914 -31.644 1.00  29.16 ? 79   ILE A CG1 1 
ATOM   584  C CG2 . ILE A 1 79  ? -8.016  -11.075 -30.614 1.00  29.54 ? 79   ILE A CG2 1 
ATOM   585  C CD1 . ILE A 1 79  ? -10.461 -13.146 -30.867 1.00  30.68 ? 79   ILE A CD1 1 
ATOM   586  N N   . ALA A 1 80  ? -9.173  -11.365 -35.319 1.00  30.02 ? 80   ALA A N   1 
ATOM   587  C CA  . ALA A 1 80  ? -9.292  -11.996 -36.635 1.00  30.14 ? 80   ALA A CA  1 
ATOM   588  C C   . ALA A 1 80  ? -8.480  -11.212 -37.664 1.00  30.32 ? 80   ALA A C   1 
ATOM   589  O O   . ALA A 1 80  ? -8.669  -11.354 -38.870 1.00  30.50 ? 80   ALA A O   1 
ATOM   590  C CB  . ALA A 1 80  ? -10.748 -12.082 -37.054 1.00  30.16 ? 80   ALA A CB  1 
ATOM   591  N N   . SER A 1 81  ? -7.589  -10.359 -37.163 1.00  30.37 ? 81   SER A N   1 
ATOM   592  C CA  . SER A 1 81  ? -6.579  -9.670  -37.969 1.00  29.94 ? 81   SER A CA  1 
ATOM   593  C C   . SER A 1 81  ? -7.100  -8.651  -38.985 1.00  29.90 ? 81   SER A C   1 
ATOM   594  O O   . SER A 1 81  ? -6.471  -8.432  -40.037 1.00  30.18 ? 81   SER A O   1 
ATOM   595  C CB  . SER A 1 81  ? -5.628  -10.669 -38.626 1.00  29.91 ? 81   SER A CB  1 
ATOM   596  O OG  . SER A 1 81  ? -5.048  -11.506 -37.647 1.00  30.19 ? 81   SER A OG  1 
ATOM   597  N N   . ALA A 1 82  ? -8.222  -8.010  -38.664 1.00  29.66 ? 82   ALA A N   1 
ATOM   598  C CA  . ALA A 1 82  ? -8.620  -6.827  -39.421 1.00  29.60 ? 82   ALA A CA  1 
ATOM   599  C C   . ALA A 1 82  ? -7.505  -5.790  -39.283 1.00  29.47 ? 82   ALA A C   1 
ATOM   600  O O   . ALA A 1 82  ? -6.874  -5.677  -38.223 1.00  29.50 ? 82   ALA A O   1 
ATOM   601  C CB  . ALA A 1 82  ? -9.931  -6.272  -38.933 1.00  29.54 ? 82   ALA A CB  1 
ATOM   602  N N   . SER A 1 83  ? -7.266  -5.064  -40.375 1.00  28.92 ? 83   SER A N   1 
ATOM   603  C CA  . SER A 1 83  ? -6.232  -4.062  -40.450 1.00  28.45 ? 83   SER A CA  1 
ATOM   604  C C   . SER A 1 83  ? -6.498  -2.924  -39.474 1.00  28.39 ? 83   SER A C   1 
ATOM   605  O O   . SER A 1 83  ? -5.582  -2.434  -38.799 1.00  28.22 ? 83   SER A O   1 
ATOM   606  C CB  . SER A 1 83  ? -6.166  -3.525  -41.876 1.00  28.50 ? 83   SER A CB  1 
ATOM   607  O OG  . SER A 1 83  ? -5.085  -2.630  -42.027 1.00  29.22 ? 83   SER A OG  1 
ATOM   608  N N   . ARG A 1 84  ? -7.763  -2.516  -39.398 1.00  28.24 ? 84   ARG A N   1 
ATOM   609  C CA  . ARG A 1 84  ? -8.179  -1.394  -38.577 1.00  28.00 ? 84   ARG A CA  1 
ATOM   610  C C   . ARG A 1 84  ? -9.667  -1.526  -38.268 1.00  27.82 ? 84   ARG A C   1 
ATOM   611  O O   . ARG A 1 84  ? -10.444 -2.003  -39.111 1.00  28.45 ? 84   ARG A O   1 
ATOM   612  C CB  . ARG A 1 84  ? -7.897  -0.100  -39.323 1.00  27.98 ? 84   ARG A CB  1 
ATOM   613  C CG  . ARG A 1 84  ? -8.001  1.141   -38.479 1.00  30.17 ? 84   ARG A CG  1 
ATOM   614  C CD  . ARG A 1 84  ? -7.501  2.372   -39.233 1.00  33.04 ? 84   ARG A CD  1 
ATOM   615  N NE  . ARG A 1 84  ? -8.209  2.521   -40.501 1.00  35.42 ? 84   ARG A NE  1 
ATOM   616  C CZ  . ARG A 1 84  ? -8.174  3.604   -41.272 1.00  36.99 ? 84   ARG A CZ  1 
ATOM   617  N NH1 . ARG A 1 84  ? -7.464  4.676   -40.928 1.00  37.22 ? 84   ARG A NH1 1 
ATOM   618  N NH2 . ARG A 1 84  ? -8.859  3.609   -42.401 1.00  38.06 ? 84   ARG A NH2 1 
ATOM   619  N N   . VAL A 1 85  ? -10.076 -1.133  -37.059 1.00  27.41 ? 85   VAL A N   1 
ATOM   620  C CA  . VAL A 1 85  ? -11.495 -1.221  -36.682 1.00  27.03 ? 85   VAL A CA  1 
ATOM   621  C C   . VAL A 1 85  ? -12.021 0.131   -36.208 1.00  27.05 ? 85   VAL A C   1 
ATOM   622  O O   . VAL A 1 85  ? -11.579 0.638   -35.193 1.00  27.67 ? 85   VAL A O   1 
ATOM   623  C CB  . VAL A 1 85  ? -11.766 -2.248  -35.556 1.00  26.71 ? 85   VAL A CB  1 
ATOM   624  C CG1 . VAL A 1 85  ? -13.250 -2.275  -35.261 1.00  27.91 ? 85   VAL A CG1 1 
ATOM   625  C CG2 . VAL A 1 85  ? -11.293 -3.637  -35.911 1.00  25.80 ? 85   VAL A CG2 1 
ATOM   626  N N   . THR A 1 86  ? -12.967 0.716   -36.929 1.00  27.23 ? 86   THR A N   1 
ATOM   627  C CA  . THR A 1 86  ? -13.575 1.981   -36.498 1.00  27.11 ? 86   THR A CA  1 
ATOM   628  C C   . THR A 1 86  ? -14.954 1.714   -35.877 1.00  27.24 ? 86   THR A C   1 
ATOM   629  O O   . THR A 1 86  ? -15.815 1.088   -36.511 1.00  27.75 ? 86   THR A O   1 
ATOM   630  C CB  . THR A 1 86  ? -13.760 2.961   -37.691 1.00  26.89 ? 86   THR A CB  1 
ATOM   631  O OG1 . THR A 1 86  ? -12.481 3.336   -38.236 1.00  27.95 ? 86   THR A OG1 1 
ATOM   632  C CG2 . THR A 1 86  ? -14.497 4.215   -37.241 1.00  26.35 ? 86   THR A CG2 1 
ATOM   633  N N   . ALA A 1 87  ? -15.170 2.185   -34.656 1.00  27.16 ? 87   ALA A N   1 
ATOM   634  C CA  . ALA A 1 87  ? -16.499 2.171   -34.072 1.00  27.74 ? 87   ALA A CA  1 
ATOM   635  C C   . ALA A 1 87  ? -17.252 3.406   -34.515 1.00  28.17 ? 87   ALA A C   1 
ATOM   636  O O   . ALA A 1 87  ? -16.798 4.536   -34.312 1.00  28.66 ? 87   ALA A O   1 
ATOM   637  C CB  . ALA A 1 87  ? -16.424 2.112   -32.559 1.00  27.72 ? 87   ALA A CB  1 
ATOM   638  N N   . VAL A 1 88  ? -18.406 3.183   -35.124 1.00  28.72 ? 88   VAL A N   1 
ATOM   639  C CA  . VAL A 1 88  ? -19.205 4.261   -35.680 1.00  29.41 ? 88   VAL A CA  1 
ATOM   640  C C   . VAL A 1 88  ? -20.357 4.393   -34.728 1.00  30.01 ? 88   VAL A C   1 
ATOM   641  O O   . VAL A 1 88  ? -21.235 3.550   -34.691 1.00  30.56 ? 88   VAL A O   1 
ATOM   642  C CB  . VAL A 1 88  ? -19.696 3.934   -37.121 1.00  29.06 ? 88   VAL A CB  1 
ATOM   643  C CG1 . VAL A 1 88  ? -20.494 5.083   -37.699 1.00  28.49 ? 88   VAL A CG1 1 
ATOM   644  C CG2 . VAL A 1 88  ? -18.517 3.622   -38.011 1.00  28.15 ? 88   VAL A CG2 1 
ATOM   645  N N   . ILE A 1 89  ? -20.325 5.440   -33.923 1.00  30.97 ? 89   ILE A N   1 
ATOM   646  C CA  . ILE A 1 89  ? -21.254 5.588   -32.813 1.00  31.78 ? 89   ILE A CA  1 
ATOM   647  C C   . ILE A 1 89  ? -21.900 6.964   -32.920 1.00  32.37 ? 89   ILE A C   1 
ATOM   648  O O   . ILE A 1 89  ? -21.512 7.896   -32.226 1.00  32.10 ? 89   ILE A O   1 
ATOM   649  C CB  . ILE A 1 89  ? -20.518 5.448   -31.453 1.00  31.60 ? 89   ILE A CB  1 
ATOM   650  C CG1 . ILE A 1 89  ? -19.791 4.130   -31.352 1.00  30.62 ? 89   ILE A CG1 1 
ATOM   651  C CG2 . ILE A 1 89  ? -21.464 5.497   -30.300 1.00  32.94 ? 89   ILE A CG2 1 
ATOM   652  C CD1 . ILE A 1 89  ? -18.697 4.180   -30.362 1.00  31.72 ? 89   ILE A CD1 1 
ATOM   653  N N   . PRO A 1 90  ? -22.889 7.110   -33.808 1.00  33.52 ? 90   PRO A N   1 
ATOM   654  C CA  . PRO A 1 90  ? -23.558 8.403   -33.874 1.00  34.19 ? 90   PRO A CA  1 
ATOM   655  C C   . PRO A 1 90  ? -23.815 8.919   -32.443 1.00  35.03 ? 90   PRO A C   1 
ATOM   656  O O   . PRO A 1 90  ? -23.332 9.994   -32.069 1.00  34.94 ? 90   PRO A O   1 
ATOM   657  C CB  . PRO A 1 90  ? -24.883 8.078   -34.570 1.00  34.07 ? 90   PRO A CB  1 
ATOM   658  C CG  . PRO A 1 90  ? -24.648 6.835   -35.324 1.00  34.05 ? 90   PRO A CG  1 
ATOM   659  C CD  . PRO A 1 90  ? -23.561 6.079   -34.624 1.00  33.95 ? 90   PRO A CD  1 
ATOM   660  N N   . CYS A 1 91  ? -24.522 8.108   -31.647 1.00  35.95 ? 91   CYS A N   1 
ATOM   661  C CA  . CYS A 1 91  ? -24.925 8.442   -30.278 1.00  36.92 ? 91   CYS A CA  1 
ATOM   662  C C   . CYS A 1 91  ? -24.053 7.749   -29.204 1.00  37.05 ? 91   CYS A C   1 
ATOM   663  O O   . CYS A 1 91  ? -24.287 6.582   -28.858 1.00  37.00 ? 91   CYS A O   1 
ATOM   664  C CB  . CYS A 1 91  ? -26.394 8.049   -30.075 1.00  37.24 ? 91   CYS A CB  1 
ATOM   665  S SG  . CYS A 1 91  ? -27.245 8.939   -28.753 1.00  38.94 ? 91   CYS A SG  1 
ATOM   666  N N   . PHE A 1 92  ? -23.073 8.486   -28.675 1.00  36.88 ? 92   PHE A N   1 
ATOM   667  C CA  . PHE A 1 92  ? -22.101 7.959   -27.710 1.00  36.81 ? 92   PHE A CA  1 
ATOM   668  C C   . PHE A 1 92  ? -22.748 7.574   -26.382 1.00  36.77 ? 92   PHE A C   1 
ATOM   669  O O   . PHE A 1 92  ? -23.237 8.448   -25.673 1.00  36.59 ? 92   PHE A O   1 
ATOM   670  C CB  . PHE A 1 92  ? -20.970 8.984   -27.460 1.00  36.84 ? 92   PHE A CB  1 
ATOM   671  C CG  . PHE A 1 92  ? -19.701 8.380   -26.888 1.00  35.81 ? 92   PHE A CG  1 
ATOM   672  C CD1 . PHE A 1 92  ? -18.698 7.904   -27.732 1.00  34.73 ? 92   PHE A CD1 1 
ATOM   673  C CD2 . PHE A 1 92  ? -19.513 8.292   -25.507 1.00  35.80 ? 92   PHE A CD2 1 
ATOM   674  C CE1 . PHE A 1 92  ? -17.540 7.340   -27.213 1.00  35.19 ? 92   PHE A CE1 1 
ATOM   675  C CE2 . PHE A 1 92  ? -18.339 7.729   -24.959 1.00  35.34 ? 92   PHE A CE2 1 
ATOM   676  C CZ  . PHE A 1 92  ? -17.354 7.254   -25.809 1.00  35.71 ? 92   PHE A CZ  1 
ATOM   677  N N   . PRO A 1 93  ? -22.733 6.266   -26.043 1.00  37.07 ? 93   PRO A N   1 
ATOM   678  C CA  . PRO A 1 93  ? -23.347 5.733   -24.814 1.00  37.21 ? 93   PRO A CA  1 
ATOM   679  C C   . PRO A 1 93  ? -22.727 6.271   -23.521 1.00  37.55 ? 93   PRO A C   1 
ATOM   680  O O   . PRO A 1 93  ? -21.515 6.189   -23.341 1.00  37.94 ? 93   PRO A O   1 
ATOM   681  C CB  . PRO A 1 93  ? -23.106 4.218   -24.909 1.00  37.05 ? 93   PRO A CB  1 
ATOM   682  C CG  . PRO A 1 93  ? -22.135 4.000   -26.030 1.00  37.33 ? 93   PRO A CG  1 
ATOM   683  C CD  . PRO A 1 93  ? -22.218 5.195   -26.924 1.00  37.25 ? 93   PRO A CD  1 
ATOM   684  N N   . TYR A 1 94  ? -23.577 6.800   -22.634 1.00  37.71 ? 94   TYR A N   1 
ATOM   685  C CA  . TYR A 1 94  ? -23.205 7.310   -21.302 1.00  37.59 ? 94   TYR A CA  1 
ATOM   686  C C   . TYR A 1 94  ? -22.546 8.675   -21.374 1.00  38.26 ? 94   TYR A C   1 
ATOM   687  O O   . TYR A 1 94  ? -21.909 9.130   -20.412 1.00  38.38 ? 94   TYR A O   1 
ATOM   688  C CB  . TYR A 1 94  ? -22.326 6.323   -20.524 1.00  37.36 ? 94   TYR A CB  1 
ATOM   689  C CG  . TYR A 1 94  ? -23.052 5.106   -20.006 1.00  35.83 ? 94   TYR A CG  1 
ATOM   690  C CD1 . TYR A 1 94  ? -23.468 4.100   -20.868 1.00  33.34 ? 94   TYR A CD1 1 
ATOM   691  C CD2 . TYR A 1 94  ? -23.292 4.949   -18.644 1.00  35.69 ? 94   TYR A CD2 1 
ATOM   692  C CE1 . TYR A 1 94  ? -24.113 2.992   -20.404 1.00  33.04 ? 94   TYR A CE1 1 
ATOM   693  C CE2 . TYR A 1 94  ? -23.943 3.832   -18.164 1.00  35.04 ? 94   TYR A CE2 1 
ATOM   694  C CZ  . TYR A 1 94  ? -24.353 2.859   -19.053 1.00  34.26 ? 94   TYR A CZ  1 
ATOM   695  O OH  . TYR A 1 94  ? -25.004 1.740   -18.583 1.00  35.16 ? 94   TYR A OH  1 
ATOM   696  N N   . ALA A 1 95  ? -22.737 9.337   -22.510 1.00  38.97 ? 95   ALA A N   1 
ATOM   697  C CA  . ALA A 1 95  ? -22.151 10.646  -22.791 1.00  39.57 ? 95   ALA A CA  1 
ATOM   698  C C   . ALA A 1 95  ? -22.475 11.724  -21.753 1.00  40.27 ? 95   ALA A C   1 
ATOM   699  O O   . ALA A 1 95  ? -21.714 12.686  -21.612 1.00  40.49 ? 95   ALA A O   1 
ATOM   700  C CB  . ALA A 1 95  ? -22.575 11.105  -24.162 1.00  39.50 ? 95   ALA A CB  1 
ATOM   701  N N   . ARG A 1 96  ? -23.593 11.571  -21.041 0.20  41.00 ? 96   ARG A N   1 
ATOM   702  C CA  . ARG A 1 96  ? -24.003 12.529  -20.006 0.20  41.79 ? 96   ARG A CA  1 
ATOM   703  C C   . ARG A 1 96  ? -23.291 12.321  -18.673 0.20  42.42 ? 96   ARG A C   1 
ATOM   704  O O   . ARG A 1 96  ? -23.308 13.200  -17.812 0.20  42.44 ? 96   ARG A O   1 
ATOM   705  C CB  . ARG A 1 96  ? -25.515 12.477  -19.803 0.20  41.74 ? 96   ARG A CB  1 
ATOM   706  C CG  . ARG A 1 96  ? -26.291 12.969  -21.002 0.20  41.83 ? 96   ARG A CG  1 
ATOM   707  C CD  . ARG A 1 96  ? -27.352 11.967  -21.381 0.20  42.01 ? 96   ARG A CD  1 
ATOM   708  N NE  . ARG A 1 96  ? -28.592 12.151  -20.636 0.20  41.80 ? 96   ARG A NE  1 
ATOM   709  C CZ  . ARG A 1 96  ? -29.536 11.221  -20.538 0.20  41.76 ? 96   ARG A CZ  1 
ATOM   710  N NH1 . ARG A 1 96  ? -29.369 10.039  -21.120 0.20  41.52 ? 96   ARG A NH1 1 
ATOM   711  N NH2 . ARG A 1 96  ? -30.642 11.471  -19.852 0.20  41.77 ? 96   ARG A NH2 1 
ATOM   712  N N   . GLN A 1 97  ? -22.673 11.155  -18.512 0.81  43.42 ? 97   GLN A N   1 
ATOM   713  C CA  . GLN A 1 97  ? -21.921 10.818  -17.297 0.81  44.32 ? 97   GLN A CA  1 
ATOM   714  C C   . GLN A 1 97  ? -20.408 11.058  -17.480 0.81  44.44 ? 97   GLN A C   1 
ATOM   715  O O   . GLN A 1 97  ? -19.565 10.141  -17.256 0.81  44.67 ? 97   GLN A O   1 
ATOM   716  C CB  . GLN A 1 97  ? -22.245 9.380   -16.863 0.81  44.44 ? 97   GLN A CB  1 
ATOM   717  C CG  . GLN A 1 97  ? -23.762 9.116   -16.804 0.81  45.87 ? 97   GLN A CG  1 
ATOM   718  C CD  . GLN A 1 97  ? -24.163 7.694   -16.396 0.81  48.27 ? 97   GLN A CD  1 
ATOM   719  O OE1 . GLN A 1 97  ? -23.410 6.952   -15.745 0.81  49.06 ? 97   GLN A OE1 1 
ATOM   720  N NE2 . GLN A 1 97  ? -25.382 7.322   -16.764 0.81  48.62 ? 97   GLN A NE2 1 
ATOM   721  N N   . ASP A 1 98  ? -20.092 12.314  -17.853 1.00  44.83 ? 98   ASP A N   1 
ATOM   722  C CA  . ASP A 1 98  ? -18.739 12.729  -18.248 1.00  45.71 ? 98   ASP A CA  1 
ATOM   723  C C   . ASP A 1 98  ? -17.959 13.516  -17.179 1.00  45.98 ? 98   ASP A C   1 
ATOM   724  O O   . ASP A 1 98  ? -16.793 13.887  -17.396 1.00  45.98 ? 98   ASP A O   1 
ATOM   725  C CB  . ASP A 1 98  ? -18.805 13.553  -19.542 1.00  45.97 ? 98   ASP A CB  1 
ATOM   726  C CG  . ASP A 1 98  ? -19.423 14.945  -19.340 1.00  47.14 ? 98   ASP A CG  1 
ATOM   727  O OD1 . ASP A 1 98  ? -20.209 15.151  -18.382 1.00  48.35 ? 98   ASP A OD1 1 
ATOM   728  O OD2 . ASP A 1 98  ? -19.126 15.837  -20.167 1.00  47.69 ? 98   ASP A OD2 1 
ATOM   729  N N   . LYS A 1 99  ? -18.618 13.791  -16.049 1.00  46.27 ? 99   LYS A N   1 
ATOM   730  C CA  . LYS A 1 99  ? -17.987 14.428  -14.888 1.00  46.30 ? 99   LYS A CA  1 
ATOM   731  C C   . LYS A 1 99  ? -18.613 13.921  -13.592 1.00  46.30 ? 99   LYS A C   1 
ATOM   732  O O   . LYS A 1 99  ? -19.707 13.358  -13.605 1.00  46.76 ? 99   LYS A O   1 
ATOM   733  C CB  . LYS A 1 99  ? -18.116 15.945  -14.972 1.00  46.43 ? 99   LYS A CB  1 
ATOM   734  C CG  . LYS A 1 99  ? -19.532 16.461  -14.809 1.00  47.71 ? 99   LYS A CG  1 
ATOM   735  C CD  . LYS A 1 99  ? -19.682 17.899  -15.324 1.00  49.76 ? 99   LYS A CD  1 
ATOM   736  C CE  . LYS A 1 99  ? -21.066 18.488  -14.963 1.00  51.32 ? 99   LYS A CE  1 
ATOM   737  N NZ  . LYS A 1 99  ? -22.252 17.678  -15.432 1.00  50.79 ? 99   LYS A NZ  1 
ATOM   738  N N   . LYS A 1 100 ? -17.914 14.121  -12.477 0.87  46.11 ? 100  LYS A N   1 
ATOM   739  C CA  . LYS A 1 100 ? -18.419 13.748  -11.164 0.87  45.47 ? 100  LYS A CA  1 
ATOM   740  C C   . LYS A 1 100 ? -19.619 14.607  -10.792 0.87  45.36 ? 100  LYS A C   1 
ATOM   741  O O   . LYS A 1 100 ? -20.666 14.080  -10.407 0.87  45.85 ? 100  LYS A O   1 
ATOM   742  C CB  . LYS A 1 100 ? -17.324 13.878  -10.103 0.87  45.52 ? 100  LYS A CB  1 
ATOM   743  C CG  . LYS A 1 100 ? -16.239 12.802  -10.178 0.87  45.33 ? 100  LYS A CG  1 
ATOM   744  C CD  . LYS A 1 100 ? -15.232 12.979  -9.055  0.87  44.34 ? 100  LYS A CD  1 
ATOM   745  C CE  . LYS A 1 100 ? -14.093 11.995  -9.182  0.87  44.35 ? 100  LYS A CE  1 
ATOM   746  N NZ  . LYS A 1 100 ? -13.243 12.013  -7.932  0.87  44.29 ? 100  LYS A NZ  1 
ATOM   747  N N   . ASP A 1 101 ? -19.470 15.925  -10.918 0.10  44.81 ? 101  ASP A N   1 
ATOM   748  C CA  . ASP A 1 101 ? -20.551 16.854  -10.598 0.10  44.27 ? 101  ASP A CA  1 
ATOM   749  C C   . ASP A 1 101 ? -20.709 16.999  -9.088  0.10  44.00 ? 101  ASP A C   1 
ATOM   750  O O   . ASP A 1 101 ? -21.825 17.021  -8.569  0.10  43.93 ? 101  ASP A O   1 
ATOM   751  C CB  . ASP A 1 101 ? -21.866 16.386  -11.226 0.10  44.24 ? 101  ASP A CB  1 
ATOM   752  C CG  . ASP A 1 101 ? -22.911 17.485  -11.285 0.10  44.06 ? 101  ASP A CG  1 
ATOM   753  O OD1 . ASP A 1 101 ? -22.555 18.629  -11.638 0.10  43.81 ? 101  ASP A OD1 1 
ATOM   754  O OD2 . ASP A 1 101 ? -24.090 17.198  -10.989 0.10  43.96 ? 101  ASP A OD2 1 
ATOM   755  N N   . LYS A 1 102 ? -19.579 17.085  -8.390  0.10  43.73 ? 102  LYS A N   1 
ATOM   756  C CA  . LYS A 1 102 ? -19.552 17.279  -6.935  0.10  43.51 ? 102  LYS A CA  1 
ATOM   757  C C   . LYS A 1 102 ? -19.927 16.057  -6.097  0.10  43.50 ? 102  LYS A C   1 
ATOM   758  O O   . LYS A 1 102 ? -19.977 16.138  -4.867  0.10  43.48 ? 102  LYS A O   1 
ATOM   759  C CB  . LYS A 1 102 ? -20.421 18.470  -6.520  0.10  43.41 ? 102  LYS A CB  1 
ATOM   760  C CG  . LYS A 1 102 ? -19.714 19.810  -6.595  0.10  43.18 ? 102  LYS A CG  1 
ATOM   761  C CD  . LYS A 1 102 ? -20.099 20.696  -5.419  0.10  42.81 ? 102  LYS A CD  1 
ATOM   762  C CE  . LYS A 1 102 ? -21.607 20.754  -5.240  0.10  42.53 ? 102  LYS A CE  1 
ATOM   763  N NZ  . LYS A 1 102 ? -21.994 21.595  -4.075  0.10  42.30 ? 102  LYS A NZ  1 
ATOM   764  N N   . SER A 1 103 ? -20.188 14.933  -6.757  1.00  43.60 ? 103  SER A N   1 
ATOM   765  C CA  . SER A 1 103 ? -20.529 13.686  -6.065  1.00  43.47 ? 103  SER A CA  1 
ATOM   766  C C   . SER A 1 103 ? -19.411 12.625  -6.190  1.00  42.88 ? 103  SER A C   1 
ATOM   767  O O   . SER A 1 103 ? -18.373 12.855  -6.839  1.00  42.75 ? 103  SER A O   1 
ATOM   768  C CB  . SER A 1 103 ? -21.868 13.134  -6.593  1.00  43.68 ? 103  SER A CB  1 
ATOM   769  O OG  . SER A 1 103 ? -22.938 13.996  -6.228  1.00  44.18 ? 103  SER A OG  1 
ATOM   770  N N   . ARG A 1 104 ? -19.633 11.476  -5.553  1.00  41.93 ? 104  ARG A N   1 
ATOM   771  C CA  . ARG A 1 104 ? -18.767 10.319  -5.681  1.00  41.11 ? 104  ARG A CA  1 
ATOM   772  C C   . ARG A 1 104 ? -19.309 9.436   -6.792  1.00  40.47 ? 104  ARG A C   1 
ATOM   773  O O   . ARG A 1 104 ? -19.360 8.216   -6.665  1.00  40.53 ? 104  ARG A O   1 
ATOM   774  C CB  . ARG A 1 104 ? -18.685 9.536   -4.358  1.00  41.37 ? 104  ARG A CB  1 
ATOM   775  C CG  . ARG A 1 104 ? -17.658 10.071  -3.362  1.00  42.19 ? 104  ARG A CG  1 
ATOM   776  C CD  . ARG A 1 104 ? -17.710 9.325   -2.029  1.00  44.20 ? 104  ARG A CD  1 
ATOM   777  N NE  . ARG A 1 104 ? -18.905 9.664   -1.249  1.00  46.34 ? 104  ARG A NE  1 
ATOM   778  C CZ  . ARG A 1 104 ? -18.956 10.609  -0.310  1.00  46.02 ? 104  ARG A CZ  1 
ATOM   779  N NH1 . ARG A 1 104 ? -17.878 11.322  -0.013  1.00  46.56 ? 104  ARG A NH1 1 
ATOM   780  N NH2 . ARG A 1 104 ? -20.088 10.837  0.334   1.00  45.70 ? 104  ARG A NH2 1 
ATOM   781  N N   . ALA A 1 105 ? -19.704 10.074  -7.891  1.00  39.93 ? 105  ALA A N   1 
ATOM   782  C CA  . ALA A 1 105 ? -20.227 9.389   -9.070  1.00  38.93 ? 105  ALA A CA  1 
ATOM   783  C C   . ALA A 1 105 ? -19.089 9.025   -10.011 1.00  38.30 ? 105  ALA A C   1 
ATOM   784  O O   . ALA A 1 105 ? -18.032 9.639   -9.956  1.00  37.93 ? 105  ALA A O   1 
ATOM   785  C CB  . ALA A 1 105 ? -21.236 10.275  -9.784  1.00  38.95 ? 105  ALA A CB  1 
ATOM   786  N N   . PRO A 1 106 ? -19.304 8.016   -10.877 1.00  37.89 ? 106  PRO A N   1 
ATOM   787  C CA  . PRO A 1 106 ? -18.291 7.593   -11.824 1.00  37.46 ? 106  PRO A CA  1 
ATOM   788  C C   . PRO A 1 106 ? -18.203 8.556   -13.014 1.00  37.19 ? 106  PRO A C   1 
ATOM   789  O O   . PRO A 1 106 ? -19.142 9.326   -13.257 1.00  37.20 ? 106  PRO A O   1 
ATOM   790  C CB  . PRO A 1 106 ? -18.836 6.251   -12.297 1.00  37.45 ? 106  PRO A CB  1 
ATOM   791  C CG  . PRO A 1 106 ? -20.327 6.499   -12.311 1.00  37.92 ? 106  PRO A CG  1 
ATOM   792  C CD  . PRO A 1 106 ? -20.555 7.245   -11.043 1.00  38.01 ? 106  PRO A CD  1 
ATOM   793  N N   . ILE A 1 107 ? -17.084 8.524   -13.735 1.00  36.66 ? 107  ILE A N   1 
ATOM   794  C CA  . ILE A 1 107 ? -17.007 9.222   -15.011 1.00  36.95 ? 107  ILE A CA  1 
ATOM   795  C C   . ILE A 1 107 ? -17.210 8.196   -16.145 1.00  36.71 ? 107  ILE A C   1 
ATOM   796  O O   . ILE A 1 107 ? -16.242 7.740   -16.812 1.00  37.03 ? 107  ILE A O   1 
ATOM   797  C CB  . ILE A 1 107 ? -15.709 10.057  -15.189 1.00  36.88 ? 107  ILE A CB  1 
ATOM   798  C CG1 . ILE A 1 107 ? -15.585 11.110  -14.087 1.00  38.38 ? 107  ILE A CG1 1 
ATOM   799  C CG2 . ILE A 1 107 ? -15.749 10.786  -16.509 1.00  37.70 ? 107  ILE A CG2 1 
ATOM   800  C CD1 . ILE A 1 107 ? -14.162 11.661  -13.887 1.00  39.75 ? 107  ILE A CD1 1 
ATOM   801  N N   . SER A 1 108 ? -18.480 7.854   -16.365 1.00  35.55 ? 108  SER A N   1 
ATOM   802  C CA  . SER A 1 108 ? -18.843 6.712   -17.191 1.00  34.46 ? 108  SER A CA  1 
ATOM   803  C C   . SER A 1 108 ? -18.382 6.807   -18.652 1.00  33.51 ? 108  SER A C   1 
ATOM   804  O O   . SER A 1 108 ? -17.922 5.815   -19.223 1.00  33.79 ? 108  SER A O   1 
ATOM   805  C CB  . SER A 1 108 ? -20.340 6.451   -17.072 1.00  34.87 ? 108  SER A CB  1 
ATOM   806  O OG  . SER A 1 108 ? -20.707 6.332   -15.693 1.00  34.78 ? 108  SER A OG  1 
ATOM   807  N N   . ALA A 1 109 ? -18.475 7.994   -19.244 1.00  32.06 ? 109  ALA A N   1 
ATOM   808  C CA  . ALA A 1 109 ? -17.927 8.237   -20.579 1.00  30.88 ? 109  ALA A CA  1 
ATOM   809  C C   . ALA A 1 109 ? -16.426 7.911   -20.680 1.00  30.17 ? 109  ALA A C   1 
ATOM   810  O O   . ALA A 1 109 ? -15.920 7.542   -21.716 1.00  29.74 ? 109  ALA A O   1 
ATOM   811  C CB  . ALA A 1 109 ? -18.187 9.656   -20.984 1.00  30.74 ? 109  ALA A CB  1 
ATOM   812  N N   . LYS A 1 110 ? -15.710 8.044   -19.579 1.00  30.23 ? 110  LYS A N   1 
ATOM   813  C CA  . LYS A 1 110 ? -14.310 7.670   -19.566 1.00  29.66 ? 110  LYS A CA  1 
ATOM   814  C C   . LYS A 1 110 ? -14.148 6.156   -19.388 1.00  29.65 ? 110  LYS A C   1 
ATOM   815  O O   . LYS A 1 110 ? -13.086 5.588   -19.726 1.00  29.43 ? 110  LYS A O   1 
ATOM   816  C CB  . LYS A 1 110 ? -13.570 8.405   -18.452 1.00  29.72 ? 110  LYS A CB  1 
ATOM   817  C CG  . LYS A 1 110 ? -12.098 8.059   -18.356 1.00  28.90 ? 110  LYS A CG  1 
ATOM   818  C CD  . LYS A 1 110 ? -11.410 8.417   -19.643 1.00  28.32 ? 110  LYS A CD  1 
ATOM   819  C CE  . LYS A 1 110 ? -10.045 7.811   -19.708 1.00  30.05 ? 110  LYS A CE  1 
ATOM   820  N NZ  . LYS A 1 110 ? -9.077  8.458   -18.789 1.00  29.61 ? 110  LYS A NZ  1 
ATOM   821  N N   . LEU A 1 111 ? -15.171 5.506   -18.828 1.00  29.20 ? 111  LEU A N   1 
ATOM   822  C CA  . LEU A 1 111 ? -15.156 4.056   -18.704 1.00  28.70 ? 111  LEU A CA  1 
ATOM   823  C C   . LEU A 1 111 ? -15.332 3.515   -20.093 1.00  28.54 ? 111  LEU A C   1 
ATOM   824  O O   . LEU A 1 111 ? -14.445 2.811   -20.596 1.00  28.75 ? 111  LEU A O   1 
ATOM   825  C CB  . LEU A 1 111 ? -16.306 3.575   -17.836 1.00  29.14 ? 111  LEU A CB  1 
ATOM   826  C CG  . LEU A 1 111 ? -16.117 2.444   -16.815 1.00  29.26 ? 111  LEU A CG  1 
ATOM   827  C CD1 . LEU A 1 111 ? -17.459 2.234   -16.099 1.00  28.51 ? 111  LEU A CD1 1 
ATOM   828  C CD2 . LEU A 1 111 ? -15.641 1.136   -17.464 1.00  28.46 ? 111  LEU A CD2 1 
ATOM   829  N N   . VAL A 1 112 ? -16.459 3.892   -20.716 1.00  27.92 ? 112  VAL A N   1 
ATOM   830  C CA  . VAL A 1 112 ? -16.846 3.449   -22.060 1.00  26.88 ? 112  VAL A CA  1 
ATOM   831  C C   . VAL A 1 112 ? -15.716 3.676   -23.039 1.00  26.75 ? 112  VAL A C   1 
ATOM   832  O O   . VAL A 1 112 ? -15.411 2.804   -23.858 1.00  27.16 ? 112  VAL A O   1 
ATOM   833  C CB  . VAL A 1 112 ? -18.106 4.177   -22.550 1.00  26.85 ? 112  VAL A CB  1 
ATOM   834  C CG1 . VAL A 1 112 ? -18.501 3.690   -23.923 1.00  25.82 ? 112  VAL A CG1 1 
ATOM   835  C CG2 . VAL A 1 112 ? -19.272 3.966   -21.549 1.00  27.69 ? 112  VAL A CG2 1 
ATOM   836  N N   . ALA A 1 113 ? -15.079 4.845   -22.928 1.00  26.25 ? 113  ALA A N   1 
ATOM   837  C CA  . ALA A 1 113 ? -13.987 5.223   -23.809 1.00  25.83 ? 113  ALA A CA  1 
ATOM   838  C C   . ALA A 1 113 ? -12.862 4.217   -23.660 1.00  25.75 ? 113  ALA A C   1 
ATOM   839  O O   . ALA A 1 113 ? -12.346 3.692   -24.656 1.00  25.69 ? 113  ALA A O   1 
ATOM   840  C CB  . ALA A 1 113 ? -13.510 6.641   -23.474 1.00  25.25 ? 113  ALA A CB  1 
ATOM   841  N N   . ASN A 1 114 ? -12.498 3.951   -22.403 1.00  25.84 ? 114  ASN A N   1 
ATOM   842  C CA  . ASN A 1 114 ? -11.486 2.950   -22.062 1.00  25.83 ? 114  ASN A CA  1 
ATOM   843  C C   . ASN A 1 114 ? -11.876 1.604   -22.619 1.00  25.75 ? 114  ASN A C   1 
ATOM   844  O O   . ASN A 1 114 ? -11.048 0.891   -23.180 1.00  25.96 ? 114  ASN A O   1 
ATOM   845  C CB  . ASN A 1 114 ? -11.328 2.806   -20.555 1.00  25.96 ? 114  ASN A CB  1 
ATOM   846  C CG  . ASN A 1 114 ? -10.563 3.958   -19.911 1.00  26.88 ? 114  ASN A CG  1 
ATOM   847  O OD1 . ASN A 1 114 ? -9.739  4.615   -20.538 1.00  27.93 ? 114  ASN A OD1 1 
ATOM   848  N ND2 . ASN A 1 114 ? -10.831 4.188   -18.628 1.00  27.60 ? 114  ASN A ND2 1 
ATOM   849  N N   . MET A 1 115 ? -13.154 1.272   -22.487 1.00  25.65 ? 115  MET A N   1 
ATOM   850  C CA  . MET A 1 115 ? -13.637 -0.032  -22.894 1.00  25.32 ? 115  MET A CA  1 
ATOM   851  C C   . MET A 1 115 ? -13.530 -0.205  -24.390 1.00  25.34 ? 115  MET A C   1 
ATOM   852  O O   . MET A 1 115 ? -13.061 -1.235  -24.862 1.00  25.53 ? 115  MET A O   1 
ATOM   853  C CB  . MET A 1 115 ? -15.057 -0.251  -22.394 1.00  25.13 ? 115  MET A CB  1 
ATOM   854  C CG  . MET A 1 115 ? -15.121 -0.386  -20.884 1.00  24.95 ? 115  MET A CG  1 
ATOM   855  S SD  . MET A 1 115 ? -16.686 -1.040  -20.311 1.00  25.75 ? 115  MET A SD  1 
ATOM   856  C CE  . MET A 1 115 ? -17.812 0.117   -21.091 1.00  25.58 ? 115  MET A CE  1 
ATOM   857  N N   . LEU A 1 116 ? -13.924 0.819   -25.139 1.00  25.41 ? 116  LEU A N   1 
ATOM   858  C CA  . LEU A 1 116 ? -13.849 0.760   -26.599 1.00  25.34 ? 116  LEU A CA  1 
ATOM   859  C C   . LEU A 1 116 ? -12.401 0.557   -27.046 1.00  25.67 ? 116  LEU A C   1 
ATOM   860  O O   . LEU A 1 116 ? -12.131 -0.194  -27.992 1.00  25.88 ? 116  LEU A O   1 
ATOM   861  C CB  . LEU A 1 116 ? -14.460 2.019   -27.226 1.00  25.26 ? 116  LEU A CB  1 
ATOM   862  C CG  . LEU A 1 116 ? -16.009 2.074   -27.089 1.00  25.31 ? 116  LEU A CG  1 
ATOM   863  C CD1 . LEU A 1 116 ? -16.628 3.522   -26.821 1.00  24.29 ? 116  LEU A CD1 1 
ATOM   864  C CD2 . LEU A 1 116 ? -16.695 1.382   -28.321 1.00  24.18 ? 116  LEU A CD2 1 
ATOM   865  N N   . SER A 1 117 ? -11.473 1.197   -26.338 1.00  25.74 ? 117  SER A N   1 
ATOM   866  C CA  . SER A 1 117 ? -10.065 1.149   -26.705 1.00  25.96 ? 117  SER A CA  1 
ATOM   867  C C   . SER A 1 117 ? -9.400  -0.187  -26.415 1.00  26.11 ? 117  SER A C   1 
ATOM   868  O O   . SER A 1 117 ? -8.695  -0.715  -27.302 1.00  26.27 ? 117  SER A O   1 
ATOM   869  C CB  . SER A 1 117 ? -9.314  2.279   -26.037 1.00  25.77 ? 117  SER A CB  1 
ATOM   870  O OG  . SER A 1 117 ? -10.126 3.431   -26.072 1.00  26.73 ? 117  SER A OG  1 
ATOM   871  N N   . VAL A 1 118 ? -9.630  -0.720  -25.203 1.00  25.96 ? 118  VAL A N   1 
ATOM   872  C CA  . VAL A 1 118 ? -9.101  -2.019  -24.799 1.00  25.79 ? 118  VAL A CA  1 
ATOM   873  C C   . VAL A 1 118 ? -9.752  -3.149  -25.580 1.00  25.95 ? 118  VAL A C   1 
ATOM   874  O O   . VAL A 1 118 ? -9.116  -4.180  -25.813 1.00  27.18 ? 118  VAL A O   1 
ATOM   875  C CB  . VAL A 1 118 ? -9.208  -2.261  -23.255 1.00  25.78 ? 118  VAL A CB  1 
ATOM   876  C CG1 . VAL A 1 118 ? -10.664 -2.338  -22.769 1.00  25.86 ? 118  VAL A CG1 1 
ATOM   877  C CG2 . VAL A 1 118 ? -8.465  -3.517  -22.854 1.00  25.89 ? 118  VAL A CG2 1 
ATOM   878  N N   . ALA A 1 119 ? -10.999 -2.968  -26.006 1.00  25.70 ? 119  ALA A N   1 
ATOM   879  C CA  . ALA A 1 119 ? -11.642 -3.997  -26.819 1.00  25.84 ? 119  ALA A CA  1 
ATOM   880  C C   . ALA A 1 119 ? -11.020 -3.988  -28.209 1.00  25.85 ? 119  ALA A C   1 
ATOM   881  O O   . ALA A 1 119 ? -11.146 -4.947  -28.960 1.00  25.71 ? 119  ALA A O   1 
ATOM   882  C CB  . ALA A 1 119 ? -13.153 -3.776  -26.888 1.00  26.45 ? 119  ALA A CB  1 
ATOM   883  N N   . GLY A 1 120 ? -10.357 -2.883  -28.547 1.00  25.93 ? 120  GLY A N   1 
ATOM   884  C CA  . GLY A 1 120 ? -9.500  -2.840  -29.712 1.00  25.41 ? 120  GLY A CA  1 
ATOM   885  C C   . GLY A 1 120 ? -9.823  -1.835  -30.792 1.00  25.43 ? 120  GLY A C   1 
ATOM   886  O O   . GLY A 1 120 ? -9.270  -1.938  -31.868 1.00  25.42 ? 120  GLY A O   1 
ATOM   887  N N   . ALA A 1 121 ? -10.704 -0.864  -30.527 1.00  25.59 ? 121  ALA A N   1 
ATOM   888  C CA  . ALA A 1 121 ? -11.070 0.144   -31.537 1.00  25.18 ? 121  ALA A CA  1 
ATOM   889  C C   . ALA A 1 121 ? -9.867  1.027   -31.854 1.00  25.49 ? 121  ALA A C   1 
ATOM   890  O O   . ALA A 1 121 ? -9.182  1.491   -30.933 1.00  25.68 ? 121  ALA A O   1 
ATOM   891  C CB  . ALA A 1 121 ? -12.222 0.991   -31.037 1.00  24.57 ? 121  ALA A CB  1 
ATOM   892  N N   . ASP A 1 122 ? -9.606  1.261   -33.136 0.50  25.47 ? 122  ASP A N   1 
ATOM   893  C CA  . ASP A 1 122 ? -8.478  2.088   -33.537 0.50  25.77 ? 122  ASP A CA  1 
ATOM   894  C C   . ASP A 1 122 ? -8.880  3.514   -33.806 0.50  26.47 ? 122  ASP A C   1 
ATOM   895  O O   . ASP A 1 122 ? -8.027  4.401   -33.913 0.50  26.44 ? 122  ASP A O   1 
ATOM   896  C CB  . ASP A 1 122 ? -7.855  1.543   -34.800 0.50  25.43 ? 122  ASP A CB  1 
ATOM   897  C CG  . ASP A 1 122 ? -7.236  0.207   -34.594 0.50  25.11 ? 122  ASP A CG  1 
ATOM   898  O OD1 . ASP A 1 122 ? -7.236  -0.583  -35.554 0.50  24.16 ? 122  ASP A OD1 1 
ATOM   899  O OD2 . ASP A 1 122 ? -6.750  -0.053  -33.469 0.50  25.45 ? 122  ASP A OD2 1 
ATOM   900  N N   . HIS A 1 123 ? -10.182 3.724   -33.940 1.00  27.58 ? 123  HIS A N   1 
ATOM   901  C CA  . HIS A 1 123 ? -10.719 4.999   -34.404 1.00  28.94 ? 123  HIS A CA  1 
ATOM   902  C C   . HIS A 1 123 ? -12.189 5.075   -34.048 1.00  29.42 ? 123  HIS A C   1 
ATOM   903  O O   . HIS A 1 123 ? -12.859 4.052   -33.978 1.00  30.31 ? 123  HIS A O   1 
ATOM   904  C CB  . HIS A 1 123 ? -10.535 5.082   -35.922 1.00  29.45 ? 123  HIS A CB  1 
ATOM   905  C CG  . HIS A 1 123 ? -10.955 6.383   -36.522 1.00  30.01 ? 123  HIS A CG  1 
ATOM   906  N ND1 . HIS A 1 123 ? -11.817 6.453   -37.593 1.00  31.67 ? 123  HIS A ND1 1 
ATOM   907  C CD2 . HIS A 1 123 ? -10.627 7.660   -36.213 1.00  30.33 ? 123  HIS A CD2 1 
ATOM   908  C CE1 . HIS A 1 123 ? -12.011 7.722   -37.911 1.00  32.28 ? 123  HIS A CE1 1 
ATOM   909  N NE2 . HIS A 1 123 ? -11.298 8.474   -37.092 1.00  31.02 ? 123  HIS A NE2 1 
ATOM   910  N N   . ILE A 1 124 ? -12.695 6.278   -33.805 1.00  29.70 ? 124  ILE A N   1 
ATOM   911  C CA  . ILE A 1 124 ? -14.111 6.448   -33.423 1.00  29.75 ? 124  ILE A CA  1 
ATOM   912  C C   . ILE A 1 124 ? -14.693 7.514   -34.341 1.00  29.94 ? 124  ILE A C   1 
ATOM   913  O O   . ILE A 1 124 ? -14.043 8.541   -34.582 1.00  29.65 ? 124  ILE A O   1 
ATOM   914  C CB  . ILE A 1 124 ? -14.280 6.898   -31.912 1.00  29.79 ? 124  ILE A CB  1 
ATOM   915  C CG1 . ILE A 1 124 ? -13.539 5.965   -30.906 1.00  30.13 ? 124  ILE A CG1 1 
ATOM   916  C CG2 . ILE A 1 124 ? -15.749 7.082   -31.539 1.00  29.37 ? 124  ILE A CG2 1 
ATOM   917  C CD1 . ILE A 1 124 ? -14.403 4.793   -30.237 1.00  32.78 ? 124  ILE A CD1 1 
ATOM   918  N N   . ILE A 1 125 ? -15.894 7.260   -34.866 1.00  30.29 ? 125  ILE A N   1 
ATOM   919  C CA  . ILE A 1 125 ? -16.631 8.255   -35.634 1.00  30.67 ? 125  ILE A CA  1 
ATOM   920  C C   . ILE A 1 125 ? -17.936 8.419   -34.909 1.00  31.43 ? 125  ILE A C   1 
ATOM   921  O O   . ILE A 1 125 ? -18.696 7.471   -34.799 1.00  31.67 ? 125  ILE A O   1 
ATOM   922  C CB  . ILE A 1 125 ? -16.884 7.829   -37.116 1.00  30.66 ? 125  ILE A CB  1 
ATOM   923  C CG1 . ILE A 1 125 ? -15.561 7.677   -37.882 1.00  30.12 ? 125  ILE A CG1 1 
ATOM   924  C CG2 . ILE A 1 125 ? -17.794 8.842   -37.826 1.00  29.35 ? 125  ILE A CG2 1 
ATOM   925  C CD1 . ILE A 1 125 ? -15.726 7.296   -39.353 1.00  30.12 ? 125  ILE A CD1 1 
ATOM   926  N N   . THR A 1 126 ? -18.177 9.619   -34.399 1.00  32.50 ? 126  THR A N   1 
ATOM   927  C CA  . THR A 1 126 ? -19.358 9.903   -33.602 1.00  33.85 ? 126  THR A CA  1 
ATOM   928  C C   . THR A 1 126 ? -19.991 11.222  -34.033 1.00  35.09 ? 126  THR A C   1 
ATOM   929  O O   . THR A 1 126 ? -19.430 11.942  -34.876 1.00  35.57 ? 126  THR A O   1 
ATOM   930  C CB  . THR A 1 126 ? -19.011 9.953   -32.093 1.00  33.92 ? 126  THR A CB  1 
ATOM   931  O OG1 . THR A 1 126 ? -20.208 10.109  -31.322 1.00  34.18 ? 126  THR A OG1 1 
ATOM   932  C CG2 . THR A 1 126 ? -18.048 11.109  -31.764 1.00  34.13 ? 126  THR A CG2 1 
ATOM   933  N N   . MET A 1 127 ? -21.137 11.551  -33.436 1.00  36.50 ? 127  MET A N   1 
ATOM   934  C CA  . MET A 1 127 ? -21.865 12.757  -33.794 1.00  37.85 ? 127  MET A CA  1 
ATOM   935  C C   . MET A 1 127 ? -22.350 13.528  -32.568 1.00  38.95 ? 127  MET A C   1 
ATOM   936  O O   . MET A 1 127 ? -22.986 12.960  -31.677 1.00  38.91 ? 127  MET A O   1 
ATOM   937  C CB  . MET A 1 127 ? -23.025 12.400  -34.726 1.00  37.65 ? 127  MET A CB  1 
ATOM   938  C CG  . MET A 1 127 ? -23.852 13.588  -35.204 1.00  38.14 ? 127  MET A CG  1 
ATOM   939  S SD  . MET A 1 127 ? -25.018 13.118  -36.499 1.00  37.94 ? 127  MET A SD  1 
ATOM   940  C CE  . MET A 1 127 ? -23.881 12.844  -37.883 1.00  37.42 ? 127  MET A CE  1 
ATOM   941  N N   . ASP A 1 128 ? -22.041 14.824  -32.547 0.95  40.55 ? 128  ASP A N   1 
ATOM   942  C CA  . ASP A 1 128 ? -22.463 15.754  -31.487 0.95  42.64 ? 128  ASP A CA  1 
ATOM   943  C C   . ASP A 1 128 ? -22.237 15.251  -30.057 0.95  43.31 ? 128  ASP A C   1 
ATOM   944  O O   . ASP A 1 128 ? -23.171 15.170  -29.257 0.95  43.76 ? 128  ASP A O   1 
ATOM   945  C CB  . ASP A 1 128 ? -23.927 16.176  -31.669 0.95  42.95 ? 128  ASP A CB  1 
ATOM   946  C CG  . ASP A 1 128 ? -24.123 17.116  -32.841 0.95  45.56 ? 128  ASP A CG  1 
ATOM   947  O OD1 . ASP A 1 128 ? -25.195 17.027  -33.482 0.95  48.37 ? 128  ASP A OD1 1 
ATOM   948  O OD2 . ASP A 1 128 ? -23.218 17.938  -33.125 0.95  47.42 ? 128  ASP A OD2 1 
ATOM   949  N N   . LEU A 1 129 ? -20.999 14.909  -29.736 1.00  44.05 ? 129  LEU A N   1 
ATOM   950  C CA  . LEU A 1 129 ? -20.670 14.482  -28.389 1.00  45.31 ? 129  LEU A CA  1 
ATOM   951  C C   . LEU A 1 129 ? -21.241 15.440  -27.352 1.00  46.14 ? 129  LEU A C   1 
ATOM   952  O O   . LEU A 1 129 ? -21.040 16.658  -27.474 1.00  46.36 ? 129  LEU A O   1 
ATOM   953  C CB  . LEU A 1 129 ? -19.165 14.432  -28.223 1.00  45.26 ? 129  LEU A CB  1 
ATOM   954  C CG  . LEU A 1 129 ? -18.520 13.176  -28.776 1.00  45.76 ? 129  LEU A CG  1 
ATOM   955  C CD1 . LEU A 1 129 ? -17.045 13.431  -29.014 1.00  47.81 ? 129  LEU A CD1 1 
ATOM   956  C CD2 . LEU A 1 129 ? -18.717 12.051  -27.788 1.00  46.39 ? 129  LEU A CD2 1 
ATOM   957  N N   . HIS A 1 130 ? -21.931 14.895  -26.337 1.00  46.93 ? 130  HIS A N   1 
ATOM   958  C CA  . HIS A 1 130 ? -22.576 15.716  -25.293 1.00  47.51 ? 130  HIS A CA  1 
ATOM   959  C C   . HIS A 1 130 ? -21.593 16.729  -24.724 1.00  47.57 ? 130  HIS A C   1 
ATOM   960  O O   . HIS A 1 130 ? -21.981 17.809  -24.265 1.00  47.78 ? 130  HIS A O   1 
ATOM   961  C CB  . HIS A 1 130 ? -23.147 14.859  -24.164 1.00  47.62 ? 130  HIS A CB  1 
ATOM   962  C CG  . HIS A 1 130 ? -23.774 15.659  -23.063 1.00  49.13 ? 130  HIS A CG  1 
ATOM   963  N ND1 . HIS A 1 130 ? -25.047 16.188  -23.154 1.00  51.19 ? 130  HIS A ND1 1 
ATOM   964  C CD2 . HIS A 1 130 ? -23.295 16.041  -21.856 1.00  50.31 ? 130  HIS A CD2 1 
ATOM   965  C CE1 . HIS A 1 130 ? -25.331 16.845  -22.042 1.00  51.30 ? 130  HIS A CE1 1 
ATOM   966  N NE2 . HIS A 1 130 ? -24.283 16.774  -21.239 1.00  51.59 ? 130  HIS A NE2 1 
ATOM   967  N N   . ALA A 1 131 ? -20.316 16.363  -24.763 1.00  47.53 ? 131  ALA A N   1 
ATOM   968  C CA  . ALA A 1 131 ? -19.236 17.286  -24.452 1.00  47.58 ? 131  ALA A CA  1 
ATOM   969  C C   . ALA A 1 131 ? -18.048 17.074  -25.401 1.00  47.64 ? 131  ALA A C   1 
ATOM   970  O O   . ALA A 1 131 ? -17.662 15.947  -25.713 1.00  47.86 ? 131  ALA A O   1 
ATOM   971  C CB  . ALA A 1 131 ? -18.809 17.134  -23.004 1.00  47.54 ? 131  ALA A CB  1 
ATOM   972  N N   . SER A 1 132 ? -17.470 18.177  -25.850 1.00  47.41 ? 132  SER A N   1 
ATOM   973  C CA  . SER A 1 132 ? -16.366 18.158  -26.796 1.00  47.39 ? 132  SER A CA  1 
ATOM   974  C C   . SER A 1 132 ? -15.097 17.532  -26.193 1.00  47.06 ? 132  SER A C   1 
ATOM   975  O O   . SER A 1 132 ? -14.212 17.007  -26.902 1.00  46.60 ? 132  SER A O   1 
ATOM   976  C CB  . SER A 1 132 ? -16.095 19.600  -27.220 1.00  47.83 ? 132  SER A CB  1 
ATOM   977  O OG  . SER A 1 132 ? -15.120 19.672  -28.254 1.00  48.85 ? 132  SER A OG  1 
ATOM   978  N N   . GLN A 1 133 ? -15.025 17.603  -24.868 0.95  46.59 ? 133  GLN A N   1 
ATOM   979  C CA  . GLN A 1 133 ? -13.906 17.057  -24.111 0.95  46.04 ? 133  GLN A CA  1 
ATOM   980  C C   . GLN A 1 133 ? -13.953 15.525  -24.007 0.95  45.19 ? 133  GLN A C   1 
ATOM   981  O O   . GLN A 1 133 ? -13.014 14.908  -23.511 0.95  45.15 ? 133  GLN A O   1 
ATOM   982  C CB  . GLN A 1 133 ? -13.844 17.701  -22.729 0.95  46.10 ? 133  GLN A CB  1 
ATOM   983  C CG  . GLN A 1 133 ? -13.723 19.225  -22.762 0.95  47.86 ? 133  GLN A CG  1 
ATOM   984  C CD  . GLN A 1 133 ? -15.067 19.949  -22.682 0.95  50.27 ? 133  GLN A CD  1 
ATOM   985  O OE1 . GLN A 1 133 ? -16.123 19.320  -22.541 0.95  51.81 ? 133  GLN A OE1 1 
ATOM   986  N NE2 . GLN A 1 133 ? -15.030 21.282  -22.756 0.95  50.29 ? 133  GLN A NE2 1 
ATOM   987  N N   . ILE A 1 134 ? -15.040 14.918  -24.485 1.00  44.15 ? 134  ILE A N   1 
ATOM   988  C CA  . ILE A 1 134 ? -15.144 13.455  -24.536 1.00  43.03 ? 134  ILE A CA  1 
ATOM   989  C C   . ILE A 1 134 ? -14.178 12.905  -25.584 1.00  41.83 ? 134  ILE A C   1 
ATOM   990  O O   . ILE A 1 134 ? -13.773 11.736  -25.522 1.00  41.89 ? 134  ILE A O   1 
ATOM   991  C CB  . ILE A 1 134 ? -16.606 12.967  -24.796 1.00  43.04 ? 134  ILE A CB  1 
ATOM   992  C CG1 . ILE A 1 134 ? -17.517 13.436  -23.656 1.00  42.78 ? 134  ILE A CG1 1 
ATOM   993  C CG2 . ILE A 1 134 ? -16.667 11.434  -24.928 1.00  43.33 ? 134  ILE A CG2 1 
ATOM   994  C CD1 . ILE A 1 134 ? -18.970 13.149  -23.869 1.00  42.93 ? 134  ILE A CD1 1 
ATOM   995  N N   . GLN A 1 135 ? -13.805 13.754  -26.538 1.00  40.27 ? 135  GLN A N   1 
ATOM   996  C CA  . GLN A 1 135 ? -12.752 13.393  -27.481 1.00  39.11 ? 135  GLN A CA  1 
ATOM   997  C C   . GLN A 1 135 ? -11.436 13.228  -26.750 1.00  37.48 ? 135  GLN A C   1 
ATOM   998  O O   . GLN A 1 135 ? -10.569 12.485  -27.200 1.00  37.41 ? 135  GLN A O   1 
ATOM   999  C CB  . GLN A 1 135 ? -12.595 14.455  -28.561 1.00  39.74 ? 135  GLN A CB  1 
ATOM   1000 C CG  . GLN A 1 135 ? -13.692 14.444  -29.616 1.00  41.77 ? 135  GLN A CG  1 
ATOM   1001 C CD  . GLN A 1 135 ? -13.472 15.498  -30.684 1.00  45.12 ? 135  GLN A CD  1 
ATOM   1002 O OE1 . GLN A 1 135 ? -13.227 15.185  -31.855 1.00  47.33 ? 135  GLN A OE1 1 
ATOM   1003 N NE2 . GLN A 1 135 ? -13.541 16.759  -30.281 1.00  46.94 ? 135  GLN A NE2 1 
ATOM   1004 N N   . GLY A 1 136 ? -11.296 13.925  -25.621 1.00  35.63 ? 136  GLY A N   1 
ATOM   1005 C CA  . GLY A 1 136 ? -10.118 13.795  -24.770 1.00  33.72 ? 136  GLY A CA  1 
ATOM   1006 C C   . GLY A 1 136 ? -10.120 12.597  -23.831 1.00  32.40 ? 136  GLY A C   1 
ATOM   1007 O O   . GLY A 1 136 ? -9.180  12.401  -23.056 1.00  32.02 ? 136  GLY A O   1 
ATOM   1008 N N   . PHE A 1 137 ? -11.171 11.789  -23.904 1.00  31.25 ? 137  PHE A N   1 
ATOM   1009 C CA  . PHE A 1 137 ? -11.260 10.574  -23.108 1.00  30.38 ? 137  PHE A CA  1 
ATOM   1010 C C   . PHE A 1 137 ? -10.545 9.395   -23.768 1.00  29.26 ? 137  PHE A C   1 
ATOM   1011 O O   . PHE A 1 137 ? -10.328 8.352   -23.139 1.00  29.58 ? 137  PHE A O   1 
ATOM   1012 C CB  . PHE A 1 137 ? -12.718 10.217  -22.857 1.00  30.63 ? 137  PHE A CB  1 
ATOM   1013 C CG  . PHE A 1 137 ? -13.404 11.115  -21.878 1.00  32.00 ? 137  PHE A CG  1 
ATOM   1014 C CD1 . PHE A 1 137 ? -14.795 11.130  -21.802 1.00  34.21 ? 137  PHE A CD1 1 
ATOM   1015 C CD2 . PHE A 1 137 ? -12.670 11.950  -21.029 1.00  33.70 ? 137  PHE A CD2 1 
ATOM   1016 C CE1 . PHE A 1 137 ? -15.452 11.960  -20.881 1.00  35.81 ? 137  PHE A CE1 1 
ATOM   1017 C CE2 . PHE A 1 137 ? -13.319 12.784  -20.099 1.00  34.24 ? 137  PHE A CE2 1 
ATOM   1018 C CZ  . PHE A 1 137 ? -14.705 12.782  -20.021 1.00  34.98 ? 137  PHE A CZ  1 
ATOM   1019 N N   . PHE A 1 138 ? -10.179 9.572   -25.033 1.00  27.63 ? 138  PHE A N   1 
ATOM   1020 C CA  . PHE A 1 138 ? -9.492  8.542   -25.803 1.00  26.10 ? 138  PHE A CA  1 
ATOM   1021 C C   . PHE A 1 138 ? -8.036  8.884   -26.014 1.00  25.84 ? 138  PHE A C   1 
ATOM   1022 O O   . PHE A 1 138 ? -7.591  9.979   -25.690 1.00  26.19 ? 138  PHE A O   1 
ATOM   1023 C CB  . PHE A 1 138 ? -10.139 8.406   -27.181 1.00  25.71 ? 138  PHE A CB  1 
ATOM   1024 C CG  . PHE A 1 138 ? -11.497 7.811   -27.154 1.00  22.63 ? 138  PHE A CG  1 
ATOM   1025 C CD1 . PHE A 1 138 ? -12.625 8.637   -27.099 1.00  20.08 ? 138  PHE A CD1 1 
ATOM   1026 C CD2 . PHE A 1 138 ? -11.643 6.416   -27.192 1.00  21.12 ? 138  PHE A CD2 1 
ATOM   1027 C CE1 . PHE A 1 138 ? -13.864 8.078   -27.093 1.00  19.38 ? 138  PHE A CE1 1 
ATOM   1028 C CE2 . PHE A 1 138 ? -12.888 5.851   -27.162 1.00  19.90 ? 138  PHE A CE2 1 
ATOM   1029 C CZ  . PHE A 1 138 ? -13.996 6.681   -27.117 1.00  18.61 ? 138  PHE A CZ  1 
ATOM   1030 N N   . ASP A 1 139 ? -7.298  7.938   -26.584 1.00  25.54 ? 139  ASP A N   1 
ATOM   1031 C CA  . ASP A 1 139 ? -5.944  8.205   -27.061 1.00  25.52 ? 139  ASP A CA  1 
ATOM   1032 C C   . ASP A 1 139 ? -5.853  7.949   -28.563 1.00  25.29 ? 139  ASP A C   1 
ATOM   1033 O O   . ASP A 1 139 ? -4.914  8.374   -29.226 1.00  25.72 ? 139  ASP A O   1 
ATOM   1034 C CB  . ASP A 1 139 ? -4.913  7.402   -26.265 1.00  25.19 ? 139  ASP A CB  1 
ATOM   1035 C CG  . ASP A 1 139 ? -4.677  8.001   -24.893 1.00  26.64 ? 139  ASP A CG  1 
ATOM   1036 O OD1 . ASP A 1 139 ? -4.172  9.142   -24.834 1.00  27.43 ? 139  ASP A OD1 1 
ATOM   1037 O OD2 . ASP A 1 139 ? -5.015  7.363   -23.865 1.00  28.12 ? 139  ASP A OD2 1 
ATOM   1038 N N   . ILE A 1 140 ? -6.861  7.260   -29.083 1.00  24.72 ? 140  ILE A N   1 
ATOM   1039 C CA  . ILE A 1 140 ? -7.033  7.013   -30.502 1.00  23.95 ? 140  ILE A CA  1 
ATOM   1040 C C   . ILE A 1 140 ? -7.783  8.176   -31.114 1.00  23.81 ? 140  ILE A C   1 
ATOM   1041 O O   . ILE A 1 140 ? -8.448  8.911   -30.388 1.00  24.46 ? 140  ILE A O   1 
ATOM   1042 C CB  . ILE A 1 140 ? -7.830  5.717   -30.728 1.00  24.00 ? 140  ILE A CB  1 
ATOM   1043 C CG1 . ILE A 1 140 ? -9.210  5.824   -30.006 1.00  24.01 ? 140  ILE A CG1 1 
ATOM   1044 C CG2 . ILE A 1 140 ? -6.960  4.499   -30.293 1.00  23.45 ? 140  ILE A CG2 1 
ATOM   1045 C CD1 . ILE A 1 140 ? -10.078 4.585   -30.040 1.00  24.31 ? 140  ILE A CD1 1 
ATOM   1046 N N   . PRO A 1 141 ? -7.648  8.386   -32.439 1.00  23.63 ? 141  PRO A N   1 
ATOM   1047 C CA  . PRO A 1 141 ? -8.363  9.461   -33.105 1.00  23.51 ? 141  PRO A CA  1 
ATOM   1048 C C   . PRO A 1 141 ? -9.870  9.305   -32.986 1.00  24.07 ? 141  PRO A C   1 
ATOM   1049 O O   . PRO A 1 141 ? -10.408 8.186   -33.083 1.00  24.73 ? 141  PRO A O   1 
ATOM   1050 C CB  . PRO A 1 141 ? -7.932  9.303   -34.554 1.00  23.13 ? 141  PRO A CB  1 
ATOM   1051 C CG  . PRO A 1 141 ? -6.600  8.764   -34.459 1.00  23.40 ? 141  PRO A CG  1 
ATOM   1052 C CD  . PRO A 1 141 ? -6.606  7.822   -33.314 1.00  23.36 ? 141  PRO A CD  1 
ATOM   1053 N N   . VAL A 1 142 ? -10.538 10.426  -32.754 1.00  24.78 ? 142  VAL A N   1 
ATOM   1054 C CA  . VAL A 1 142 ? -11.981 10.499  -32.749 1.00  25.66 ? 142  VAL A CA  1 
ATOM   1055 C C   . VAL A 1 142 ? -12.372 11.550  -33.790 1.00  26.65 ? 142  VAL A C   1 
ATOM   1056 O O   . VAL A 1 142 ? -11.843 12.645  -33.759 1.00  27.37 ? 142  VAL A O   1 
ATOM   1057 C CB  . VAL A 1 142 ? -12.464 10.928  -31.351 1.00  25.13 ? 142  VAL A CB  1 
ATOM   1058 C CG1 . VAL A 1 142 ? -13.946 11.193  -31.336 1.00  25.83 ? 142  VAL A CG1 1 
ATOM   1059 C CG2 . VAL A 1 142 ? -12.110 9.882   -30.336 1.00  23.97 ? 142  VAL A CG2 1 
ATOM   1060 N N   . ASP A 1 143 ? -13.249 11.210  -34.732 0.93  27.83 ? 143  ASP A N   1 
ATOM   1061 C CA  . ASP A 1 143 ? -13.862 12.205  -35.628 0.93  28.96 ? 143  ASP A CA  1 
ATOM   1062 C C   . ASP A 1 143 ? -15.282 12.572  -35.185 0.93  30.12 ? 143  ASP A C   1 
ATOM   1063 O O   . ASP A 1 143 ? -16.243 11.818  -35.443 0.93  30.05 ? 143  ASP A O   1 
ATOM   1064 C CB  . ASP A 1 143 ? -13.895 11.701  -37.074 0.93  28.65 ? 143  ASP A CB  1 
ATOM   1065 C CG  . ASP A 1 143 ? -12.523 11.744  -37.750 0.93  29.46 ? 143  ASP A CG  1 
ATOM   1066 O OD1 . ASP A 1 143 ? -11.837 12.804  -37.714 0.93  30.23 ? 143  ASP A OD1 1 
ATOM   1067 O OD2 . ASP A 1 143 ? -12.120 10.716  -38.340 0.93  28.78 ? 143  ASP A OD2 1 
ATOM   1068 N N   . ASN A 1 144 ? -15.420 13.730  -34.531 1.00  31.84 ? 144  ASN A N   1 
ATOM   1069 C CA  . ASN A 1 144 ? -16.724 14.160  -34.018 1.00  33.66 ? 144  ASN A CA  1 
ATOM   1070 C C   . ASN A 1 144 ? -17.485 15.035  -34.997 1.00  34.64 ? 144  ASN A C   1 
ATOM   1071 O O   . ASN A 1 144 ? -17.097 16.174  -35.250 1.00  35.00 ? 144  ASN A O   1 
ATOM   1072 C CB  . ASN A 1 144 ? -16.594 14.866  -32.658 1.00  33.47 ? 144  ASN A CB  1 
ATOM   1073 C CG  . ASN A 1 144 ? -17.944 15.141  -32.014 1.00  33.83 ? 144  ASN A CG  1 
ATOM   1074 O OD1 . ASN A 1 144 ? -18.909 14.397  -32.214 1.00  35.17 ? 144  ASN A OD1 1 
ATOM   1075 N ND2 . ASN A 1 144 ? -18.016 16.201  -31.230 1.00  33.83 ? 144  ASN A ND2 1 
ATOM   1076 N N   . LEU A 1 145 ? -18.578 14.497  -35.527 1.00  36.10 ? 145  LEU A N   1 
ATOM   1077 C CA  . LEU A 1 145 ? -19.359 15.183  -36.554 1.00  37.62 ? 145  LEU A CA  1 
ATOM   1078 C C   . LEU A 1 145 ? -20.426 16.097  -35.939 1.00  39.08 ? 145  LEU A C   1 
ATOM   1079 O O   . LEU A 1 145 ? -20.835 15.901  -34.791 1.00  40.08 ? 145  LEU A O   1 
ATOM   1080 C CB  . LEU A 1 145 ? -19.978 14.161  -37.511 1.00  37.33 ? 145  LEU A CB  1 
ATOM   1081 C CG  . LEU A 1 145 ? -19.034 13.134  -38.153 1.00  36.05 ? 145  LEU A CG  1 
ATOM   1082 C CD1 . LEU A 1 145 ? -19.804 12.236  -39.076 1.00  36.33 ? 145  LEU A CD1 1 
ATOM   1083 C CD2 . LEU A 1 145 ? -17.920 13.812  -38.907 1.00  34.06 ? 145  LEU A CD2 1 
ATOM   1084 N N   . TYR A 1 146 ? -20.854 17.110  -36.686 1.00  40.22 ? 146  TYR A N   1 
ATOM   1085 C CA  . TYR A 1 146 ? -21.858 18.038  -36.190 1.00  41.33 ? 146  TYR A CA  1 
ATOM   1086 C C   . TYR A 1 146 ? -23.135 17.905  -36.992 1.00  41.80 ? 146  TYR A C   1 
ATOM   1087 O O   . TYR A 1 146 ? -23.098 17.646  -38.192 1.00  41.98 ? 146  TYR A O   1 
ATOM   1088 C CB  . TYR A 1 146 ? -21.337 19.470  -36.259 1.00  41.62 ? 146  TYR A CB  1 
ATOM   1089 C CG  . TYR A 1 146 ? -19.971 19.617  -35.652 1.00  43.21 ? 146  TYR A CG  1 
ATOM   1090 C CD1 . TYR A 1 146 ? -18.821 19.329  -36.401 1.00  44.45 ? 146  TYR A CD1 1 
ATOM   1091 C CD2 . TYR A 1 146 ? -19.816 20.030  -34.326 1.00  44.93 ? 146  TYR A CD2 1 
ATOM   1092 C CE1 . TYR A 1 146 ? -17.544 19.442  -35.841 1.00  45.40 ? 146  TYR A CE1 1 
ATOM   1093 C CE2 . TYR A 1 146 ? -18.540 20.151  -33.752 1.00  46.23 ? 146  TYR A CE2 1 
ATOM   1094 C CZ  . TYR A 1 146 ? -17.411 19.849  -34.518 1.00  46.53 ? 146  TYR A CZ  1 
ATOM   1095 O OH  . TYR A 1 146 ? -16.156 19.961  -33.963 1.00  47.34 ? 146  TYR A OH  1 
ATOM   1096 N N   . ALA A 1 147 ? -24.266 18.065  -36.314 1.00  42.38 ? 147  ALA A N   1 
ATOM   1097 C CA  . ALA A 1 147 ? -25.553 18.143  -36.988 1.00  42.89 ? 147  ALA A CA  1 
ATOM   1098 C C   . ALA A 1 147 ? -25.855 19.601  -37.264 1.00  43.21 ? 147  ALA A C   1 
ATOM   1099 O O   . ALA A 1 147 ? -26.761 19.915  -38.040 1.00  43.82 ? 147  ALA A O   1 
ATOM   1100 C CB  . ALA A 1 147 ? -26.643 17.540  -36.134 1.00  42.89 ? 147  ALA A CB  1 
ATOM   1101 N N   . GLU A 1 148 ? -25.083 20.478  -36.623 1.00  43.13 ? 148  GLU A N   1 
ATOM   1102 C CA  . GLU A 1 148 ? -25.192 21.924  -36.782 1.00  43.50 ? 148  GLU A CA  1 
ATOM   1103 C C   . GLU A 1 148 ? -25.648 22.375  -38.176 1.00  43.17 ? 148  GLU A C   1 
ATOM   1104 O O   . GLU A 1 148 ? -26.689 23.034  -38.288 1.00  42.89 ? 148  GLU A O   1 
ATOM   1105 C CB  . GLU A 1 148 ? -23.869 22.601  -36.386 1.00  44.03 ? 148  GLU A CB  1 
ATOM   1106 C CG  . GLU A 1 148 ? -23.786 24.109  -36.671 1.00  46.68 ? 148  GLU A CG  1 
ATOM   1107 C CD  . GLU A 1 148 ? -22.991 24.866  -35.599 1.00  51.37 ? 148  GLU A CD  1 
ATOM   1108 O OE1 . GLU A 1 148 ? -22.000 24.307  -35.065 1.00  52.97 ? 148  GLU A OE1 1 
ATOM   1109 O OE2 . GLU A 1 148 ? -23.355 26.029  -35.286 1.00  53.06 ? 148  GLU A OE2 1 
ATOM   1110 N N   . PRO A 1 149 ? -24.890 22.013  -39.238 1.00  43.01 ? 149  PRO A N   1 
ATOM   1111 C CA  . PRO A 1 149 ? -25.267 22.523  -40.540 1.00  43.09 ? 149  PRO A CA  1 
ATOM   1112 C C   . PRO A 1 149 ? -26.597 21.935  -41.019 1.00  43.44 ? 149  PRO A C   1 
ATOM   1113 O O   . PRO A 1 149 ? -27.391 22.648  -41.642 1.00  43.59 ? 149  PRO A O   1 
ATOM   1114 C CB  . PRO A 1 149 ? -24.110 22.080  -41.434 1.00  43.14 ? 149  PRO A CB  1 
ATOM   1115 C CG  . PRO A 1 149 ? -23.008 21.742  -40.488 1.00  42.94 ? 149  PRO A CG  1 
ATOM   1116 C CD  . PRO A 1 149 ? -23.701 21.154  -39.340 1.00  42.82 ? 149  PRO A CD  1 
ATOM   1117 N N   . ALA A 1 150 ? -26.856 20.667  -40.696 1.00  43.54 ? 150  ALA A N   1 
ATOM   1118 C CA  . ALA A 1 150 ? -28.103 20.009  -41.101 1.00  43.86 ? 150  ALA A CA  1 
ATOM   1119 C C   . ALA A 1 150 ? -29.332 20.591  -40.393 1.00  43.92 ? 150  ALA A C   1 
ATOM   1120 O O   . ALA A 1 150 ? -30.459 20.493  -40.892 1.00  44.03 ? 150  ALA A O   1 
ATOM   1121 C CB  . ALA A 1 150 ? -28.008 18.513  -40.855 1.00  44.08 ? 150  ALA A CB  1 
ATOM   1122 N N   . VAL A 1 151 ? -29.088 21.184  -39.227 1.00  43.92 ? 151  VAL A N   1 
ATOM   1123 C CA  . VAL A 1 151 ? -30.109 21.810  -38.397 1.00  43.95 ? 151  VAL A CA  1 
ATOM   1124 C C   . VAL A 1 151 ? -30.461 23.191  -38.949 1.00  44.15 ? 151  VAL A C   1 
ATOM   1125 O O   . VAL A 1 151 ? -31.640 23.515  -39.150 1.00  44.15 ? 151  VAL A O   1 
ATOM   1126 C CB  . VAL A 1 151 ? -29.607 21.904  -36.934 1.00  43.87 ? 151  VAL A CB  1 
ATOM   1127 C CG1 . VAL A 1 151 ? -30.461 22.842  -36.096 1.00  44.13 ? 151  VAL A CG1 1 
ATOM   1128 C CG2 . VAL A 1 151 ? -29.565 20.524  -36.309 1.00  43.63 ? 151  VAL A CG2 1 
ATOM   1129 N N   . LEU A 1 152 ? -29.419 23.987  -39.189 1.00  44.42 ? 152  LEU A N   1 
ATOM   1130 C CA  . LEU A 1 152 ? -29.524 25.306  -39.807 1.00  44.44 ? 152  LEU A CA  1 
ATOM   1131 C C   . LEU A 1 152 ? -30.307 25.269  -41.110 1.00  44.85 ? 152  LEU A C   1 
ATOM   1132 O O   . LEU A 1 152 ? -31.297 25.995  -41.270 1.00  44.94 ? 152  LEU A O   1 
ATOM   1133 C CB  . LEU A 1 152 ? -28.124 25.849  -40.075 1.00  44.16 ? 152  LEU A CB  1 
ATOM   1134 C CG  . LEU A 1 152 ? -27.515 26.854  -39.100 1.00  43.17 ? 152  LEU A CG  1 
ATOM   1135 C CD1 . LEU A 1 152 ? -28.115 26.781  -37.698 1.00  41.91 ? 152  LEU A CD1 1 
ATOM   1136 C CD2 . LEU A 1 152 ? -26.001 26.698  -39.100 1.00  41.60 ? 152  LEU A CD2 1 
ATOM   1137 N N   . LYS A 1 153 ? -29.857 24.421  -42.034 0.60  45.24 ? 153  LYS A N   1 
ATOM   1138 C CA  . LYS A 1 153 ? -30.557 24.210  -43.293 0.60  45.72 ? 153  LYS A CA  1 
ATOM   1139 C C   . LYS A 1 153 ? -32.046 24.039  -43.019 0.60  46.05 ? 153  LYS A C   1 
ATOM   1140 O O   . LYS A 1 153 ? -32.864 24.791  -43.555 0.60  45.96 ? 153  LYS A O   1 
ATOM   1141 C CB  . LYS A 1 153 ? -29.999 22.987  -44.032 0.60  45.85 ? 153  LYS A CB  1 
ATOM   1142 C CG  . LYS A 1 153 ? -30.679 22.695  -45.367 0.60  46.26 ? 153  LYS A CG  1 
ATOM   1143 C CD  . LYS A 1 153 ? -30.048 21.516  -46.083 0.60  46.87 ? 153  LYS A CD  1 
ATOM   1144 C CE  . LYS A 1 153 ? -30.465 21.461  -47.557 0.60  47.51 ? 153  LYS A CE  1 
ATOM   1145 N NZ  . LYS A 1 153 ? -31.858 20.948  -47.786 0.60  47.55 ? 153  LYS A NZ  1 
ATOM   1146 N N   . TRP A 1 154 ? -32.382 23.076  -42.159 1.00  46.65 ? 154  TRP A N   1 
ATOM   1147 C CA  . TRP A 1 154 ? -33.780 22.763  -41.843 1.00  47.50 ? 154  TRP A CA  1 
ATOM   1148 C C   . TRP A 1 154 ? -34.552 23.959  -41.285 1.00  47.99 ? 154  TRP A C   1 
ATOM   1149 O O   . TRP A 1 154 ? -35.646 24.277  -41.779 1.00  48.37 ? 154  TRP A O   1 
ATOM   1150 C CB  . TRP A 1 154 ? -33.892 21.586  -40.875 1.00  47.58 ? 154  TRP A CB  1 
ATOM   1151 C CG  . TRP A 1 154 ? -35.297 21.090  -40.761 1.00  48.45 ? 154  TRP A CG  1 
ATOM   1152 C CD1 . TRP A 1 154 ? -35.859 20.054  -41.461 1.00  49.44 ? 154  TRP A CD1 1 
ATOM   1153 C CD2 . TRP A 1 154 ? -36.334 21.618  -39.928 1.00  48.94 ? 154  TRP A CD2 1 
ATOM   1154 N NE1 . TRP A 1 154 ? -37.174 19.900  -41.104 1.00  49.29 ? 154  TRP A NE1 1 
ATOM   1155 C CE2 . TRP A 1 154 ? -37.494 20.846  -40.167 1.00  49.38 ? 154  TRP A CE2 1 
ATOM   1156 C CE3 . TRP A 1 154 ? -36.397 22.665  -38.998 1.00  50.21 ? 154  TRP A CE3 1 
ATOM   1157 C CZ2 . TRP A 1 154 ? -38.707 21.089  -39.512 1.00  50.41 ? 154  TRP A CZ2 1 
ATOM   1158 C CZ3 . TRP A 1 154 ? -37.602 22.907  -38.340 1.00  50.90 ? 154  TRP A CZ3 1 
ATOM   1159 C CH2 . TRP A 1 154 ? -38.742 22.120  -38.603 1.00  51.10 ? 154  TRP A CH2 1 
ATOM   1160 N N   . ILE A 1 155 ? -33.993 24.596  -40.250 1.00  48.17 ? 155  ILE A N   1 
ATOM   1161 C CA  . ILE A 1 155 ? -34.561 25.819  -39.668 1.00  48.35 ? 155  ILE A CA  1 
ATOM   1162 C C   . ILE A 1 155 ? -34.915 26.834  -40.766 1.00  48.76 ? 155  ILE A C   1 
ATOM   1163 O O   . ILE A 1 155 ? -36.074 27.254  -40.898 1.00  48.59 ? 155  ILE A O   1 
ATOM   1164 C CB  . ILE A 1 155 ? -33.590 26.449  -38.624 1.00  48.07 ? 155  ILE A CB  1 
ATOM   1165 C CG1 . ILE A 1 155 ? -33.477 25.535  -37.411 1.00  47.78 ? 155  ILE A CG1 1 
ATOM   1166 C CG2 . ILE A 1 155 ? -34.031 27.856  -38.227 1.00  47.70 ? 155  ILE A CG2 1 
ATOM   1167 C CD1 . ILE A 1 155 ? -32.811 26.164  -36.181 1.00  48.70 ? 155  ILE A CD1 1 
ATOM   1168 N N   . ARG A 1 156 ? -33.915 27.194  -41.562 1.00  49.28 ? 156  ARG A N   1 
ATOM   1169 C CA  . ARG A 1 156 ? -34.116 28.151  -42.635 1.00  50.42 ? 156  ARG A CA  1 
ATOM   1170 C C   . ARG A 1 156 ? -35.223 27.704  -43.606 1.00  50.58 ? 156  ARG A C   1 
ATOM   1171 O O   . ARG A 1 156 ? -36.066 28.508  -44.012 1.00  50.33 ? 156  ARG A O   1 
ATOM   1172 C CB  . ARG A 1 156 ? -32.794 28.408  -43.373 1.00  50.65 ? 156  ARG A CB  1 
ATOM   1173 C CG  . ARG A 1 156 ? -31.686 29.022  -42.495 1.00  51.38 ? 156  ARG A CG  1 
ATOM   1174 C CD  . ARG A 1 156 ? -30.577 29.576  -43.383 1.00  53.36 ? 156  ARG A CD  1 
ATOM   1175 N NE  . ARG A 1 156 ? -29.257 29.527  -42.751 1.00  55.35 ? 156  ARG A NE  1 
ATOM   1176 C CZ  . ARG A 1 156 ? -28.479 28.441  -42.694 1.00  55.96 ? 156  ARG A CZ  1 
ATOM   1177 N NH1 . ARG A 1 156 ? -28.882 27.284  -43.222 1.00  56.32 ? 156  ARG A NH1 1 
ATOM   1178 N NH2 . ARG A 1 156 ? -27.287 28.506  -42.105 1.00  55.97 ? 156  ARG A NH2 1 
ATOM   1179 N N   . GLU A 1 157 ? -35.220 26.412  -43.933 1.00  51.05 ? 157  GLU A N   1 
ATOM   1180 C CA  . GLU A 1 157 ? -36.119 25.848  -44.935 1.00  51.77 ? 157  GLU A CA  1 
ATOM   1181 C C   . GLU A 1 157 ? -37.497 25.468  -44.407 1.00  51.53 ? 157  GLU A C   1 
ATOM   1182 O O   . GLU A 1 157 ? -38.348 25.013  -45.181 1.00  51.48 ? 157  GLU A O   1 
ATOM   1183 C CB  . GLU A 1 157 ? -35.487 24.618  -45.592 1.00  52.23 ? 157  GLU A CB  1 
ATOM   1184 C CG  . GLU A 1 157 ? -34.293 24.926  -46.489 1.00  54.87 ? 157  GLU A CG  1 
ATOM   1185 C CD  . GLU A 1 157 ? -33.628 23.665  -47.032 1.00  58.61 ? 157  GLU A CD  1 
ATOM   1186 O OE1 . GLU A 1 157 ? -32.827 23.784  -47.996 1.00  59.90 ? 157  GLU A OE1 1 
ATOM   1187 O OE2 . GLU A 1 157 ? -33.901 22.556  -46.495 1.00  59.50 ? 157  GLU A OE2 1 
ATOM   1188 N N   . ASN A 1 158 ? -37.729 25.633  -43.105 1.00  51.33 ? 158  ASN A N   1 
ATOM   1189 C CA  . ASN A 1 158 ? -39.006 25.190  -42.539 1.00  51.24 ? 158  ASN A CA  1 
ATOM   1190 C C   . ASN A 1 158 ? -39.724 26.178  -41.619 1.00  51.16 ? 158  ASN A C   1 
ATOM   1191 O O   . ASN A 1 158 ? -40.920 26.022  -41.346 1.00  51.08 ? 158  ASN A O   1 
ATOM   1192 C CB  . ASN A 1 158 ? -38.850 23.823  -41.858 1.00  51.39 ? 158  ASN A CB  1 
ATOM   1193 C CG  . ASN A 1 158 ? -38.416 22.727  -42.830 1.00  51.36 ? 158  ASN A CG  1 
ATOM   1194 O OD1 . ASN A 1 158 ? -37.234 22.585  -43.127 1.00  52.37 ? 158  ASN A OD1 1 
ATOM   1195 N ND2 . ASN A 1 158 ? -39.370 21.947  -43.318 1.00  50.63 ? 158  ASN A ND2 1 
ATOM   1196 N N   . ILE A 1 159 ? -38.996 27.192  -41.161 1.00  51.17 ? 159  ILE A N   1 
ATOM   1197 C CA  . ILE A 1 159 ? -39.522 28.197  -40.235 1.00  51.16 ? 159  ILE A CA  1 
ATOM   1198 C C   . ILE A 1 159 ? -39.549 29.587  -40.899 1.00  51.35 ? 159  ILE A C   1 
ATOM   1199 O O   . ILE A 1 159 ? -38.547 30.310  -40.919 1.00  51.25 ? 159  ILE A O   1 
ATOM   1200 C CB  . ILE A 1 159 ? -38.710 28.176  -38.916 1.00  51.13 ? 159  ILE A CB  1 
ATOM   1201 C CG1 . ILE A 1 159 ? -38.986 26.855  -38.186 1.00  51.66 ? 159  ILE A CG1 1 
ATOM   1202 C CG2 . ILE A 1 159 ? -39.025 29.379  -38.026 1.00  51.13 ? 159  ILE A CG2 1 
ATOM   1203 C CD1 . ILE A 1 159 ? -37.976 26.474  -37.109 1.00  52.22 ? 159  ILE A CD1 1 
ATOM   1204 N N   . SER A 1 160 ? -40.711 29.939  -41.445 1.00  51.41 ? 160  SER A N   1 
ATOM   1205 C CA  . SER A 1 160 ? -40.886 31.164  -42.226 1.00  51.59 ? 160  SER A CA  1 
ATOM   1206 C C   . SER A 1 160 ? -40.294 32.412  -41.571 1.00  51.67 ? 160  SER A C   1 
ATOM   1207 O O   . SER A 1 160 ? -39.668 33.248  -42.247 1.00  51.70 ? 160  SER A O   1 
ATOM   1208 C CB  . SER A 1 160 ? -42.367 31.374  -42.516 1.00  51.41 ? 160  SER A CB  1 
ATOM   1209 O OG  . SER A 1 160 ? -43.145 30.715  -41.533 1.00  51.85 ? 160  SER A OG  1 
ATOM   1210 N N   . GLU A 1 161 ? -40.466 32.514  -40.258 0.95  51.62 ? 161  GLU A N   1 
ATOM   1211 C CA  . GLU A 1 161 ? -40.089 33.723  -39.536 0.95  52.17 ? 161  GLU A CA  1 
ATOM   1212 C C   . GLU A 1 161 ? -38.674 33.658  -38.947 0.95  52.31 ? 161  GLU A C   1 
ATOM   1213 O O   . GLU A 1 161 ? -38.233 34.596  -38.278 0.95  52.45 ? 161  GLU A O   1 
ATOM   1214 C CB  . GLU A 1 161 ? -41.129 34.052  -38.451 0.95  52.27 ? 161  GLU A CB  1 
ATOM   1215 C CG  . GLU A 1 161 ? -42.607 33.993  -38.915 0.95  53.22 ? 161  GLU A CG  1 
ATOM   1216 C CD  . GLU A 1 161 ? -43.190 32.565  -38.927 0.95  54.49 ? 161  GLU A CD  1 
ATOM   1217 O OE1 . GLU A 1 161 ? -42.418 31.582  -38.771 0.95  54.58 ? 161  GLU A OE1 1 
ATOM   1218 O OE2 . GLU A 1 161 ? -44.430 32.434  -39.087 0.95  54.35 ? 161  GLU A OE2 1 
ATOM   1219 N N   . TRP A 1 162 ? -37.954 32.570  -39.233 1.00  52.59 ? 162  TRP A N   1 
ATOM   1220 C CA  . TRP A 1 162 ? -36.632 32.312  -38.636 1.00  52.59 ? 162  TRP A CA  1 
ATOM   1221 C C   . TRP A 1 162 ? -35.728 33.530  -38.531 1.00  52.94 ? 162  TRP A C   1 
ATOM   1222 O O   . TRP A 1 162 ? -34.949 33.636  -37.577 1.00  53.20 ? 162  TRP A O   1 
ATOM   1223 C CB  . TRP A 1 162 ? -35.891 31.165  -39.347 1.00  52.48 ? 162  TRP A CB  1 
ATOM   1224 C CG  . TRP A 1 162 ? -35.328 31.438  -40.738 1.00  51.85 ? 162  TRP A CG  1 
ATOM   1225 C CD1 . TRP A 1 162 ? -35.961 31.239  -41.930 1.00  52.23 ? 162  TRP A CD1 1 
ATOM   1226 C CD2 . TRP A 1 162 ? -34.009 31.888  -41.061 1.00  51.58 ? 162  TRP A CD2 1 
ATOM   1227 N NE1 . TRP A 1 162 ? -35.126 31.548  -42.977 1.00  51.82 ? 162  TRP A NE1 1 
ATOM   1228 C CE2 . TRP A 1 162 ? -33.921 31.953  -42.471 1.00  52.08 ? 162  TRP A CE2 1 
ATOM   1229 C CE3 . TRP A 1 162 ? -32.890 32.246  -40.295 1.00  52.56 ? 162  TRP A CE3 1 
ATOM   1230 C CZ2 . TRP A 1 162 ? -32.758 32.369  -43.135 1.00  52.87 ? 162  TRP A CZ2 1 
ATOM   1231 C CZ3 . TRP A 1 162 ? -31.725 32.659  -40.953 1.00  52.68 ? 162  TRP A CZ3 1 
ATOM   1232 C CH2 . TRP A 1 162 ? -31.673 32.716  -42.360 1.00  53.48 ? 162  TRP A CH2 1 
ATOM   1233 N N   . ARG A 1 163 ? -35.855 34.444  -39.500 1.00  53.00 ? 163  ARG A N   1 
ATOM   1234 C CA  . ARG A 1 163 ? -34.992 35.621  -39.599 1.00  52.89 ? 163  ARG A CA  1 
ATOM   1235 C C   . ARG A 1 163 ? -35.096 36.495  -38.361 1.00  52.73 ? 163  ARG A C   1 
ATOM   1236 O O   . ARG A 1 163 ? -34.158 37.226  -38.022 1.00  53.09 ? 163  ARG A O   1 
ATOM   1237 C CB  . ARG A 1 163 ? -35.275 36.416  -40.881 1.00  53.04 ? 163  ARG A CB  1 
ATOM   1238 C CG  . ARG A 1 163 ? -34.881 35.666  -42.167 1.00  53.84 ? 163  ARG A CG  1 
ATOM   1239 C CD  . ARG A 1 163 ? -34.374 36.614  -43.242 1.00  55.52 ? 163  ARG A CD  1 
ATOM   1240 N NE  . ARG A 1 163 ? -34.060 35.930  -44.500 1.00  57.28 ? 163  ARG A NE  1 
ATOM   1241 C CZ  . ARG A 1 163 ? -32.825 35.632  -44.919 1.00  58.05 ? 163  ARG A CZ  1 
ATOM   1242 N NH1 . ARG A 1 163 ? -31.760 35.943  -44.185 1.00  57.64 ? 163  ARG A NH1 1 
ATOM   1243 N NH2 . ARG A 1 163 ? -32.640 35.019  -46.083 1.00  58.52 ? 163  ARG A NH2 1 
ATOM   1244 N N   . ASN A 1 164 ? -36.226 36.390  -37.672 0.94  52.47 ? 164  ASN A N   1 
ATOM   1245 C CA  . ASN A 1 164 ? -36.389 37.051  -36.388 0.94  52.53 ? 164  ASN A CA  1 
ATOM   1246 C C   . ASN A 1 164 ? -36.800 36.080  -35.277 0.94  52.42 ? 164  ASN A C   1 
ATOM   1247 O O   . ASN A 1 164 ? -37.615 36.426  -34.415 0.94  52.60 ? 164  ASN A O   1 
ATOM   1248 C CB  . ASN A 1 164 ? -37.392 38.219  -36.494 0.94  52.72 ? 164  ASN A CB  1 
ATOM   1249 C CG  . ASN A 1 164 ? -36.909 39.339  -37.422 0.94  52.58 ? 164  ASN A CG  1 
ATOM   1250 O OD1 . ASN A 1 164 ? -37.604 39.705  -38.362 0.94  52.84 ? 164  ASN A OD1 1 
ATOM   1251 N ND2 . ASN A 1 164 ? -35.717 39.879  -37.160 0.94  52.16 ? 164  ASN A ND2 1 
ATOM   1252 N N   . CYS A 1 165 ? -36.246 34.867  -35.290 1.00  52.01 ? 165  CYS A N   1 
ATOM   1253 C CA  . CYS A 1 165 ? -36.576 33.907  -34.235 1.00  51.96 ? 165  CYS A CA  1 
ATOM   1254 C C   . CYS A 1 165 ? -35.536 33.921  -33.110 1.00  51.44 ? 165  CYS A C   1 
ATOM   1255 O O   . CYS A 1 165 ? -34.515 34.614  -33.202 1.00  51.75 ? 165  CYS A O   1 
ATOM   1256 C CB  . CYS A 1 165 ? -36.728 32.499  -34.795 1.00  51.83 ? 165  CYS A CB  1 
ATOM   1257 S SG  . CYS A 1 165 ? -35.195 31.590  -34.742 1.00  54.46 ? 165  CYS A SG  1 
ATOM   1258 N N   . THR A 1 166 ? -35.815 33.154  -32.056 1.00  50.52 ? 166  THR A N   1 
ATOM   1259 C CA  . THR A 1 166 ? -34.951 33.050  -30.888 1.00  49.60 ? 166  THR A CA  1 
ATOM   1260 C C   . THR A 1 166 ? -34.618 31.585  -30.654 1.00  49.01 ? 166  THR A C   1 
ATOM   1261 O O   . THR A 1 166 ? -35.527 30.747  -30.534 1.00  48.94 ? 166  THR A O   1 
ATOM   1262 C CB  . THR A 1 166 ? -35.658 33.586  -29.611 1.00  49.83 ? 166  THR A CB  1 
ATOM   1263 O OG1 . THR A 1 166 ? -36.126 34.925  -29.830 1.00  49.71 ? 166  THR A OG1 1 
ATOM   1264 C CG2 . THR A 1 166 ? -34.712 33.544  -28.394 1.00  49.31 ? 166  THR A CG2 1 
ATOM   1265 N N   . ILE A 1 167 ? -33.324 31.278  -30.579 1.00  48.18 ? 167  ILE A N   1 
ATOM   1266 C CA  . ILE A 1 167 ? -32.882 29.910  -30.290 1.00  47.39 ? 167  ILE A CA  1 
ATOM   1267 C C   . ILE A 1 167 ? -32.671 29.780  -28.799 1.00  46.75 ? 167  ILE A C   1 
ATOM   1268 O O   . ILE A 1 167 ? -31.781 30.414  -28.250 1.00  46.85 ? 167  ILE A O   1 
ATOM   1269 C CB  . ILE A 1 167 ? -31.569 29.534  -31.013 1.00  47.37 ? 167  ILE A CB  1 
ATOM   1270 C CG1 . ILE A 1 167 ? -31.560 30.044  -32.460 1.00  47.35 ? 167  ILE A CG1 1 
ATOM   1271 C CG2 . ILE A 1 167 ? -31.327 28.016  -30.925 1.00  47.50 ? 167  ILE A CG2 1 
ATOM   1272 C CD1 . ILE A 1 167 ? -32.587 29.387  -33.393 1.00  48.00 ? 167  ILE A CD1 1 
ATOM   1273 N N   . VAL A 1 168 ? -33.492 28.961  -28.149 1.00  46.19 ? 168  VAL A N   1 
ATOM   1274 C CA  . VAL A 1 168 ? -33.489 28.867  -26.690 1.00  45.58 ? 168  VAL A CA  1 
ATOM   1275 C C   . VAL A 1 168 ? -32.890 27.564  -26.247 1.00  45.22 ? 168  VAL A C   1 
ATOM   1276 O O   . VAL A 1 168 ? -33.064 26.550  -26.909 1.00  45.49 ? 168  VAL A O   1 
ATOM   1277 C CB  . VAL A 1 168 ? -34.908 28.944  -26.099 1.00  45.67 ? 168  VAL A CB  1 
ATOM   1278 C CG1 . VAL A 1 168 ? -34.892 28.611  -24.593 1.00  45.48 ? 168  VAL A CG1 1 
ATOM   1279 C CG2 . VAL A 1 168 ? -35.526 30.321  -26.354 1.00  45.84 ? 168  VAL A CG2 1 
ATOM   1280 N N   . SER A 1 169 ? -32.199 27.601  -25.112 1.00  44.80 ? 169  SER A N   1 
ATOM   1281 C CA  . SER A 1 169 ? -31.658 26.410  -24.477 1.00  44.20 ? 169  SER A CA  1 
ATOM   1282 C C   . SER A 1 169 ? -32.507 25.974  -23.295 1.00  44.10 ? 169  SER A C   1 
ATOM   1283 O O   . SER A 1 169 ? -32.900 26.800  -22.471 1.00  44.15 ? 169  SER A O   1 
ATOM   1284 C CB  . SER A 1 169 ? -30.234 26.661  -23.989 1.00  44.32 ? 169  SER A CB  1 
ATOM   1285 O OG  . SER A 1 169 ? -29.838 25.652  -23.077 1.00  43.75 ? 169  SER A OG  1 
ATOM   1286 N N   . PRO A 1 170 ? -32.778 24.661  -23.206 1.00  44.01 ? 170  PRO A N   1 
ATOM   1287 C CA  . PRO A 1 170 ? -33.450 23.932  -22.125 1.00  44.03 ? 170  PRO A CA  1 
ATOM   1288 C C   . PRO A 1 170 ? -32.858 24.144  -20.728 1.00  44.12 ? 170  PRO A C   1 
ATOM   1289 O O   . PRO A 1 170 ? -33.613 24.243  -19.759 1.00  44.08 ? 170  PRO A O   1 
ATOM   1290 C CB  . PRO A 1 170 ? -33.230 22.473  -22.512 1.00  43.63 ? 170  PRO A CB  1 
ATOM   1291 C CG  . PRO A 1 170 ? -33.160 22.485  -23.941 1.00  44.04 ? 170  PRO A CG  1 
ATOM   1292 C CD  . PRO A 1 170 ? -32.522 23.779  -24.352 1.00  44.12 ? 170  PRO A CD  1 
ATOM   1293 N N   . ASP A 1 171 ? -31.524 24.171  -20.638 1.00  44.10 ? 171  ASP A N   1 
ATOM   1294 C CA  . ASP A 1 171 ? -30.805 24.322  -19.369 1.00  43.95 ? 171  ASP A CA  1 
ATOM   1295 C C   . ASP A 1 171 ? -29.637 25.310  -19.499 1.00  44.02 ? 171  ASP A C   1 
ATOM   1296 O O   . ASP A 1 171 ? -29.344 25.797  -20.600 1.00  44.24 ? 171  ASP A O   1 
ATOM   1297 C CB  . ASP A 1 171 ? -30.309 22.957  -18.867 1.00  43.80 ? 171  ASP A CB  1 
ATOM   1298 C CG  . ASP A 1 171 ? -29.456 22.204  -19.905 1.00  44.86 ? 171  ASP A CG  1 
ATOM   1299 O OD1 . ASP A 1 171 ? -29.115 21.014  -19.656 1.00  45.27 ? 171  ASP A OD1 1 
ATOM   1300 O OD2 . ASP A 1 171 ? -29.112 22.779  -20.967 1.00  46.27 ? 171  ASP A OD2 1 
ATOM   1301 N N   . ALA A 1 172 ? -28.981 25.603  -18.377 1.00  43.85 ? 172  ALA A N   1 
ATOM   1302 C CA  . ALA A 1 172 ? -27.834 26.516  -18.355 1.00  44.20 ? 172  ALA A CA  1 
ATOM   1303 C C   . ALA A 1 172 ? -26.595 26.004  -19.118 1.00  44.27 ? 172  ALA A C   1 
ATOM   1304 O O   . ALA A 1 172 ? -25.868 26.788  -19.737 1.00  44.23 ? 172  ALA A O   1 
ATOM   1305 C CB  . ALA A 1 172 ? -27.461 26.852  -16.921 1.00  44.43 ? 172  ALA A CB  1 
ATOM   1306 N N   . GLY A 1 173 ? -26.356 24.695  -19.059 1.00  44.08 ? 173  GLY A N   1 
ATOM   1307 C CA  . GLY A 1 173 ? -25.225 24.077  -19.752 1.00  43.86 ? 173  GLY A CA  1 
ATOM   1308 C C   . GLY A 1 173 ? -25.254 24.170  -21.271 1.00  43.58 ? 173  GLY A C   1 
ATOM   1309 O O   . GLY A 1 173 ? -24.202 24.127  -21.926 1.00  43.74 ? 173  GLY A O   1 
ATOM   1310 N N   . GLY A 1 174 ? -26.448 24.301  -21.840 1.00  43.13 ? 174  GLY A N   1 
ATOM   1311 C CA  . GLY A 1 174 ? -26.593 24.376  -23.297 1.00  42.66 ? 174  GLY A CA  1 
ATOM   1312 C C   . GLY A 1 174 ? -26.246 25.719  -23.918 1.00  42.16 ? 174  GLY A C   1 
ATOM   1313 O O   . GLY A 1 174 ? -26.382 25.884  -25.132 1.00  42.35 ? 174  GLY A O   1 
ATOM   1314 N N   . ALA A 1 175 ? -25.782 26.665  -23.097 1.00  41.54 ? 175  ALA A N   1 
ATOM   1315 C CA  . ALA A 1 175 ? -25.541 28.038  -23.539 1.00  41.16 ? 175  ALA A CA  1 
ATOM   1316 C C   . ALA A 1 175 ? -24.665 28.103  -24.779 1.00  41.02 ? 175  ALA A C   1 
ATOM   1317 O O   . ALA A 1 175 ? -25.004 28.781  -25.750 1.00  41.20 ? 175  ALA A O   1 
ATOM   1318 C CB  . ALA A 1 175 ? -24.934 28.855  -22.431 1.00  41.02 ? 175  ALA A CB  1 
ATOM   1319 N N   . LYS A 1 176 ? -23.553 27.377  -24.743 0.80  40.64 ? 176  LYS A N   1 
ATOM   1320 C CA  . LYS A 1 176 ? -22.579 27.379  -25.824 0.80  40.26 ? 176  LYS A CA  1 
ATOM   1321 C C   . LYS A 1 176 ? -23.155 26.891  -27.145 0.80  40.39 ? 176  LYS A C   1 
ATOM   1322 O O   . LYS A 1 176 ? -22.901 27.487  -28.201 0.80  40.44 ? 176  LYS A O   1 
ATOM   1323 C CB  . LYS A 1 176 ? -21.387 26.522  -25.440 0.80  40.07 ? 176  LYS A CB  1 
ATOM   1324 C CG  . LYS A 1 176 ? -20.121 26.933  -26.131 0.80  40.22 ? 176  LYS A CG  1 
ATOM   1325 C CD  . LYS A 1 176 ? -18.905 26.537  -25.326 0.80  39.63 ? 176  LYS A CD  1 
ATOM   1326 C CE  . LYS A 1 176 ? -17.705 27.349  -25.756 0.80  39.75 ? 176  LYS A CE  1 
ATOM   1327 N NZ  . LYS A 1 176 ? -17.915 28.803  -25.525 0.80  40.27 ? 176  LYS A NZ  1 
ATOM   1328 N N   . ARG A 1 177 ? -23.937 25.816  -27.080 0.70  40.31 ? 177  ARG A N   1 
ATOM   1329 C CA  . ARG A 1 177 ? -24.495 25.195  -28.275 0.70  40.41 ? 177  ARG A CA  1 
ATOM   1330 C C   . ARG A 1 177 ? -25.553 26.068  -28.958 0.70  40.34 ? 177  ARG A C   1 
ATOM   1331 O O   . ARG A 1 177 ? -25.592 26.151  -30.191 0.70  40.52 ? 177  ARG A O   1 
ATOM   1332 C CB  . ARG A 1 177 ? -25.074 23.828  -27.924 0.70  40.52 ? 177  ARG A CB  1 
ATOM   1333 C CG  . ARG A 1 177 ? -25.205 22.874  -29.106 0.70  40.94 ? 177  ARG A CG  1 
ATOM   1334 C CD  . ARG A 1 177 ? -26.042 21.651  -28.743 0.70  41.78 ? 177  ARG A CD  1 
ATOM   1335 N NE  . ARG A 1 177 ? -25.369 20.796  -27.768 0.70  42.35 ? 177  ARG A NE  1 
ATOM   1336 C CZ  . ARG A 1 177 ? -25.666 20.741  -26.471 0.70  42.65 ? 177  ARG A CZ  1 
ATOM   1337 N NH1 . ARG A 1 177 ? -26.643 21.483  -25.962 0.70  43.17 ? 177  ARG A NH1 1 
ATOM   1338 N NH2 . ARG A 1 177 ? -24.981 19.931  -25.681 0.70  43.31 ? 177  ARG A NH2 1 
ATOM   1339 N N   . VAL A 1 178 ? -26.405 26.710  -28.161 1.00  40.11 ? 178  VAL A N   1 
ATOM   1340 C CA  . VAL A 1 178 ? -27.446 27.596  -28.718 1.00  40.06 ? 178  VAL A CA  1 
ATOM   1341 C C   . VAL A 1 178 ? -26.917 28.935  -29.246 1.00  39.75 ? 178  VAL A C   1 
ATOM   1342 O O   . VAL A 1 178 ? -27.494 29.501  -30.177 1.00  39.54 ? 178  VAL A O   1 
ATOM   1343 C CB  . VAL A 1 178 ? -28.650 27.850  -27.732 1.00  40.18 ? 178  VAL A CB  1 
ATOM   1344 C CG1 . VAL A 1 178 ? -29.332 26.517  -27.368 1.00  39.87 ? 178  VAL A CG1 1 
ATOM   1345 C CG2 . VAL A 1 178 ? -28.216 28.652  -26.490 1.00  39.41 ? 178  VAL A CG2 1 
ATOM   1346 N N   . THR A 1 179 ? -25.830 29.425  -28.645 1.00  39.58 ? 179  THR A N   1 
ATOM   1347 C CA  . THR A 1 179 ? -25.285 30.747  -28.963 1.00  39.26 ? 179  THR A CA  1 
ATOM   1348 C C   . THR A 1 179 ? -24.516 30.694  -30.266 1.00  39.44 ? 179  THR A C   1 
ATOM   1349 O O   . THR A 1 179 ? -24.423 31.685  -30.985 1.00  39.23 ? 179  THR A O   1 
ATOM   1350 C CB  . THR A 1 179 ? -24.409 31.322  -27.823 1.00  38.87 ? 179  THR A CB  1 
ATOM   1351 O OG1 . THR A 1 179 ? -23.543 30.309  -27.305 1.00  38.41 ? 179  THR A OG1 1 
ATOM   1352 C CG2 . THR A 1 179 ? -25.275 31.801  -26.709 1.00  39.01 ? 179  THR A CG2 1 
ATOM   1353 N N   . SER A 1 180 ? -23.970 29.521  -30.559 1.00  39.92 ? 180  SER A N   1 
ATOM   1354 C CA  . SER A 1 180 ? -23.383 29.260  -31.854 1.00  40.50 ? 180  SER A CA  1 
ATOM   1355 C C   . SER A 1 180 ? -24.466 29.206  -32.948 1.00  40.95 ? 180  SER A C   1 
ATOM   1356 O O   . SER A 1 180 ? -24.306 29.831  -34.001 1.00  41.41 ? 180  SER A O   1 
ATOM   1357 C CB  . SER A 1 180 ? -22.537 27.994  -31.812 1.00  40.31 ? 180  SER A CB  1 
ATOM   1358 O OG  . SER A 1 180 ? -22.545 27.333  -33.060 1.00  40.79 ? 180  SER A OG  1 
ATOM   1359 N N   . ILE A 1 181 ? -25.564 28.490  -32.699 1.00  41.28 ? 181  ILE A N   1 
ATOM   1360 C CA  . ILE A 1 181 ? -26.680 28.446  -33.658 1.00  41.95 ? 181  ILE A CA  1 
ATOM   1361 C C   . ILE A 1 181 ? -27.350 29.815  -33.823 1.00  42.30 ? 181  ILE A C   1 
ATOM   1362 O O   . ILE A 1 181 ? -27.755 30.187  -34.929 1.00  42.66 ? 181  ILE A O   1 
ATOM   1363 C CB  . ILE A 1 181 ? -27.721 27.334  -33.305 1.00  42.37 ? 181  ILE A CB  1 
ATOM   1364 C CG1 . ILE A 1 181 ? -27.246 25.961  -33.820 1.00  42.57 ? 181  ILE A CG1 1 
ATOM   1365 C CG2 . ILE A 1 181 ? -29.104 27.646  -33.894 1.00  42.30 ? 181  ILE A CG2 1 
ATOM   1366 C CD1 . ILE A 1 181 ? -27.767 24.765  -33.018 1.00  42.00 ? 181  ILE A CD1 1 
ATOM   1367 N N   . ALA A 1 182 ? -27.448 30.563  -32.723 1.00  42.79 ? 182  ALA A N   1 
ATOM   1368 C CA  . ALA A 1 182 ? -27.921 31.954  -32.740 1.00  43.09 ? 182  ALA A CA  1 
ATOM   1369 C C   . ALA A 1 182 ? -27.006 32.857  -33.582 1.00  43.48 ? 182  ALA A C   1 
ATOM   1370 O O   . ALA A 1 182 ? -27.464 33.825  -34.210 1.00  43.68 ? 182  ALA A O   1 
ATOM   1371 C CB  . ALA A 1 182 ? -28.021 32.486  -31.320 1.00  42.73 ? 182  ALA A CB  1 
ATOM   1372 N N   . ASP A 1 183 ? -25.717 32.527  -33.594 1.00  43.67 ? 183  ASP A N   1 
ATOM   1373 C CA  . ASP A 1 183 ? -24.745 33.338  -34.292 1.00  44.20 ? 183  ASP A CA  1 
ATOM   1374 C C   . ASP A 1 183 ? -24.747 33.113  -35.801 1.00  44.64 ? 183  ASP A C   1 
ATOM   1375 O O   . ASP A 1 183 ? -24.854 34.078  -36.567 1.00  44.94 ? 183  ASP A O   1 
ATOM   1376 C CB  . ASP A 1 183 ? -23.355 33.176  -33.679 1.00  43.94 ? 183  ASP A CB  1 
ATOM   1377 C CG  . ASP A 1 183 ? -23.234 33.880  -32.351 1.00  44.19 ? 183  ASP A CG  1 
ATOM   1378 O OD1 . ASP A 1 183 ? -24.100 34.719  -32.051 1.00  45.84 ? 183  ASP A OD1 1 
ATOM   1379 O OD2 . ASP A 1 183 ? -22.285 33.610  -31.594 1.00  45.12 ? 183  ASP A OD2 1 
ATOM   1380 N N   . ARG A 1 184 ? -24.634 31.852  -36.217 0.40  45.07 ? 184  ARG A N   1 
ATOM   1381 C CA  . ARG A 1 184 ? -24.648 31.485  -37.635 0.40  45.64 ? 184  ARG A CA  1 
ATOM   1382 C C   . ARG A 1 184 ? -25.858 32.057  -38.368 0.40  46.14 ? 184  ARG A C   1 
ATOM   1383 O O   . ARG A 1 184 ? -25.766 32.444  -39.533 0.40  46.08 ? 184  ARG A O   1 
ATOM   1384 C CB  . ARG A 1 184 ? -24.619 29.966  -37.790 0.40  45.59 ? 184  ARG A CB  1 
ATOM   1385 C CG  . ARG A 1 184 ? -23.234 29.357  -37.694 0.40  46.13 ? 184  ARG A CG  1 
ATOM   1386 C CD  . ARG A 1 184 ? -22.440 29.955  -36.543 0.40  46.93 ? 184  ARG A CD  1 
ATOM   1387 N NE  . ARG A 1 184 ? -21.346 29.079  -36.128 0.40  47.20 ? 184  ARG A NE  1 
ATOM   1388 C CZ  . ARG A 1 184 ? -20.475 29.371  -35.165 0.40  47.04 ? 184  ARG A CZ  1 
ATOM   1389 N NH1 . ARG A 1 184 ? -20.567 30.522  -34.508 0.40  46.61 ? 184  ARG A NH1 1 
ATOM   1390 N NH2 . ARG A 1 184 ? -19.511 28.509  -34.860 0.40  46.87 ? 184  ARG A NH2 1 
ATOM   1391 N N   . LEU A 1 185 ? -26.984 32.113  -37.668 1.00  47.00 ? 185  LEU A N   1 
ATOM   1392 C CA  . LEU A 1 185 ? -28.225 32.644  -38.218 1.00  47.74 ? 185  LEU A CA  1 
ATOM   1393 C C   . LEU A 1 185 ? -28.355 34.165  -38.049 1.00  48.26 ? 185  LEU A C   1 
ATOM   1394 O O   . LEU A 1 185 ? -29.160 34.800  -38.733 1.00  48.78 ? 185  LEU A O   1 
ATOM   1395 C CB  . LEU A 1 185 ? -29.432 31.929  -37.580 1.00  47.74 ? 185  LEU A CB  1 
ATOM   1396 C CG  . LEU A 1 185 ? -29.572 30.400  -37.746 1.00  48.00 ? 185  LEU A CG  1 
ATOM   1397 C CD1 . LEU A 1 185 ? -30.744 29.822  -36.903 1.00  47.10 ? 185  LEU A CD1 1 
ATOM   1398 C CD2 . LEU A 1 185 ? -29.711 29.983  -39.232 1.00  47.93 ? 185  LEU A CD2 1 
ATOM   1399 N N   . ASN A 1 186 ? -27.561 34.747  -37.148 1.00  48.76 ? 186  ASN A N   1 
ATOM   1400 C CA  . ASN A 1 186 ? -27.693 36.166  -36.765 1.00  49.24 ? 186  ASN A CA  1 
ATOM   1401 C C   . ASN A 1 186 ? -29.051 36.540  -36.165 1.00  49.15 ? 186  ASN A C   1 
ATOM   1402 O O   . ASN A 1 186 ? -29.710 37.489  -36.614 1.00  49.41 ? 186  ASN A O   1 
ATOM   1403 C CB  . ASN A 1 186 ? -27.324 37.121  -37.912 1.00  49.38 ? 186  ASN A CB  1 
ATOM   1404 C CG  . ASN A 1 186 ? -26.145 38.000  -37.566 1.00  50.35 ? 186  ASN A CG  1 
ATOM   1405 O OD1 . ASN A 1 186 ? -26.325 39.144  -37.133 1.00  52.17 ? 186  ASN A OD1 1 
ATOM   1406 N ND2 . ASN A 1 186 ? -24.932 37.465  -37.719 1.00  50.80 ? 186  ASN A ND2 1 
ATOM   1407 N N   . VAL A 1 187 ? -29.453 35.782  -35.147 1.00  48.74 ? 187  VAL A N   1 
ATOM   1408 C CA  . VAL A 1 187 ? -30.683 36.056  -34.414 1.00  48.50 ? 187  VAL A CA  1 
ATOM   1409 C C   . VAL A 1 187 ? -30.434 35.933  -32.905 1.00  48.16 ? 187  VAL A C   1 
ATOM   1410 O O   . VAL A 1 187 ? -29.356 35.499  -32.487 1.00  47.79 ? 187  VAL A O   1 
ATOM   1411 C CB  . VAL A 1 187 ? -31.872 35.146  -34.873 1.00  48.56 ? 187  VAL A CB  1 
ATOM   1412 C CG1 . VAL A 1 187 ? -31.917 35.043  -36.391 1.00  48.56 ? 187  VAL A CG1 1 
ATOM   1413 C CG2 . VAL A 1 187 ? -31.806 33.747  -34.226 1.00  48.76 ? 187  VAL A CG2 1 
ATOM   1414 N N   . ASP A 1 188 ? -31.434 36.329  -32.112 0.90  47.89 ? 188  ASP A N   1 
ATOM   1415 C CA  . ASP A 1 188 ? -31.382 36.293  -30.648 0.90  47.65 ? 188  ASP A CA  1 
ATOM   1416 C C   . ASP A 1 188 ? -31.282 34.886  -30.076 0.90  47.42 ? 188  ASP A C   1 
ATOM   1417 O O   . ASP A 1 188 ? -31.864 33.945  -30.622 0.90  47.46 ? 188  ASP A O   1 
ATOM   1418 C CB  . ASP A 1 188 ? -32.649 36.925  -30.062 0.90  47.58 ? 188  ASP A CB  1 
ATOM   1419 C CG  . ASP A 1 188 ? -32.663 38.435  -30.166 0.90  47.56 ? 188  ASP A CG  1 
ATOM   1420 O OD1 . ASP A 1 188 ? -31.573 39.045  -30.268 0.90  46.27 ? 188  ASP A OD1 1 
ATOM   1421 O OD2 . ASP A 1 188 ? -33.780 39.010  -30.122 0.90  48.50 ? 188  ASP A OD2 1 
ATOM   1422 N N   . PHE A 1 189 ? -30.565 34.758  -28.961 1.00  47.09 ? 189  PHE A N   1 
ATOM   1423 C CA  . PHE A 1 189 ? -30.651 33.552  -28.127 1.00  46.86 ? 189  PHE A CA  1 
ATOM   1424 C C   . PHE A 1 189 ? -31.273 33.862  -26.772 1.00  46.71 ? 189  PHE A C   1 
ATOM   1425 O O   . PHE A 1 189 ? -31.325 35.022  -26.352 1.00  47.03 ? 189  PHE A O   1 
ATOM   1426 C CB  . PHE A 1 189 ? -29.275 32.902  -27.922 1.00  46.80 ? 189  PHE A CB  1 
ATOM   1427 C CG  . PHE A 1 189 ? -28.411 33.590  -26.894 1.00  46.05 ? 189  PHE A CG  1 
ATOM   1428 C CD1 . PHE A 1 189 ? -28.430 33.184  -25.565 1.00  46.17 ? 189  PHE A CD1 1 
ATOM   1429 C CD2 . PHE A 1 189 ? -27.563 34.630  -27.260 1.00  45.52 ? 189  PHE A CD2 1 
ATOM   1430 C CE1 . PHE A 1 189 ? -27.625 33.812  -24.616 1.00  46.05 ? 189  PHE A CE1 1 
ATOM   1431 C CE2 . PHE A 1 189 ? -26.752 35.261  -26.322 1.00  44.60 ? 189  PHE A CE2 1 
ATOM   1432 C CZ  . PHE A 1 189 ? -26.782 34.857  -25.000 1.00  45.05 ? 189  PHE A CZ  1 
ATOM   1433 N N   . ALA A 1 190 ? -31.727 32.814  -26.090 1.00  46.37 ? 190  ALA A N   1 
ATOM   1434 C CA  . ALA A 1 190 ? -32.171 32.922  -24.703 1.00  46.23 ? 190  ALA A CA  1 
ATOM   1435 C C   . ALA A 1 190 ? -31.865 31.629  -23.976 1.00  46.21 ? 190  ALA A C   1 
ATOM   1436 O O   . ALA A 1 190 ? -31.387 30.676  -24.584 1.00  45.99 ? 190  ALA A O   1 
ATOM   1437 C CB  . ALA A 1 190 ? -33.654 33.237  -24.630 1.00  46.16 ? 190  ALA A CB  1 
ATOM   1438 N N   . LEU A 1 191 ? -32.155 31.591  -22.679 1.00  46.40 ? 191  LEU A N   1 
ATOM   1439 C CA  . LEU A 1 191 ? -31.805 30.438  -21.859 1.00  46.67 ? 191  LEU A CA  1 
ATOM   1440 C C   . LEU A 1 191 ? -32.739 30.245  -20.678 1.00  46.85 ? 191  LEU A C   1 
ATOM   1441 O O   . LEU A 1 191 ? -33.213 31.214  -20.074 1.00  47.11 ? 191  LEU A O   1 
ATOM   1442 C CB  . LEU A 1 191 ? -30.359 30.568  -21.377 1.00  46.94 ? 191  LEU A CB  1 
ATOM   1443 C CG  . LEU A 1 191 ? -29.716 29.414  -20.617 1.00  46.84 ? 191  LEU A CG  1 
ATOM   1444 C CD1 . LEU A 1 191 ? -28.293 29.239  -21.119 1.00  47.20 ? 191  LEU A CD1 1 
ATOM   1445 C CD2 . LEU A 1 191 ? -29.749 29.717  -19.126 1.00  47.18 ? 191  LEU A CD2 1 
ATOM   1446 N N   . ILE A 1 192 ? -32.973 28.977  -20.352 1.00  46.88 ? 192  ILE A N   1 
ATOM   1447 C CA  . ILE A 1 192 ? -33.888 28.572  -19.287 1.00  46.99 ? 192  ILE A CA  1 
ATOM   1448 C C   . ILE A 1 192 ? -33.095 27.851  -18.212 1.00  47.02 ? 192  ILE A C   1 
ATOM   1449 O O   . ILE A 1 192 ? -32.075 27.245  -18.498 1.00  47.19 ? 192  ILE A O   1 
ATOM   1450 C CB  . ILE A 1 192 ? -35.019 27.651  -19.830 1.00  46.93 ? 192  ILE A CB  1 
ATOM   1451 C CG1 . ILE A 1 192 ? -36.094 28.485  -20.525 1.00  47.73 ? 192  ILE A CG1 1 
ATOM   1452 C CG2 . ILE A 1 192 ? -35.653 26.812  -18.719 1.00  46.78 ? 192  ILE A CG2 1 
ATOM   1453 C CD1 . ILE A 1 192 ? -37.165 27.649  -21.243 1.00  49.43 ? 192  ILE A CD1 1 
ATOM   1454 N N   . HIS A 1 193 ? -33.571 27.908  -16.976 1.00  47.39 ? 193  HIS A N   1 
ATOM   1455 C CA  . HIS A 1 193 ? -32.849 27.317  -15.849 1.00  47.69 ? 193  HIS A CA  1 
ATOM   1456 C C   . HIS A 1 193 ? -33.797 26.990  -14.700 1.00  47.64 ? 193  HIS A C   1 
ATOM   1457 O O   . HIS A 1 193 ? -34.449 27.883  -14.145 1.00  47.64 ? 193  HIS A O   1 
ATOM   1458 C CB  . HIS A 1 193 ? -31.757 28.279  -15.373 1.00  47.83 ? 193  HIS A CB  1 
ATOM   1459 C CG  . HIS A 1 193 ? -31.192 27.939  -14.035 1.00  48.03 ? 193  HIS A CG  1 
ATOM   1460 N ND1 . HIS A 1 193 ? -30.401 26.829  -13.826 1.00  49.03 ? 193  HIS A ND1 1 
ATOM   1461 C CD2 . HIS A 1 193 ? -31.288 28.565  -12.838 1.00  48.96 ? 193  HIS A CD2 1 
ATOM   1462 C CE1 . HIS A 1 193 ? -30.042 26.778  -12.555 1.00  49.15 ? 193  HIS A CE1 1 
ATOM   1463 N NE2 . HIS A 1 193 ? -30.566 27.821  -11.933 1.00  49.89 ? 193  HIS A NE2 1 
ATOM   1464 N N   . LYS A 1 194 ? -33.872 25.711  -14.352 0.30  47.57 ? 194  LYS A N   1 
ATOM   1465 C CA  . LYS A 1 194 ? -34.741 25.279  -13.272 0.30  47.68 ? 194  LYS A CA  1 
ATOM   1466 C C   . LYS A 1 194 ? -34.108 25.567  -11.923 0.30  47.86 ? 194  LYS A C   1 
ATOM   1467 O O   . LYS A 1 194 ? -33.080 24.986  -11.567 0.30  47.61 ? 194  LYS A O   1 
ATOM   1468 C CB  . LYS A 1 194 ? -35.087 23.794  -13.384 0.30  47.69 ? 194  LYS A CB  1 
ATOM   1469 C CG  . LYS A 1 194 ? -36.042 23.329  -12.291 0.30  47.66 ? 194  LYS A CG  1 
ATOM   1470 C CD  . LYS A 1 194 ? -36.572 21.928  -12.550 0.30  47.67 ? 194  LYS A CD  1 
ATOM   1471 C CE  . LYS A 1 194 ? -37.780 21.643  -11.662 0.30  47.64 ? 194  LYS A CE  1 
ATOM   1472 N NZ  . LYS A 1 194 ? -38.472 20.375  -12.037 0.30  47.76 ? 194  LYS A NZ  1 
ATOM   1473 N N   . GLU A 1 195 ? -34.745 26.477  -11.189 0.80  48.37 ? 195  GLU A N   1 
ATOM   1474 C CA  . GLU A 1 195 ? -34.322 26.907  -9.857  0.80  48.70 ? 195  GLU A CA  1 
ATOM   1475 C C   . GLU A 1 195 ? -34.102 25.719  -8.914  0.80  48.70 ? 195  GLU A C   1 
ATOM   1476 O O   . GLU A 1 195 ? -34.979 24.846  -8.772  0.80  48.77 ? 195  GLU A O   1 
ATOM   1477 C CB  . GLU A 1 195 ? -35.385 27.842  -9.269  0.80  48.91 ? 195  GLU A CB  1 
ATOM   1478 C CG  . GLU A 1 195 ? -34.841 29.110  -8.635  0.80  50.07 ? 195  GLU A CG  1 
ATOM   1479 C CD  . GLU A 1 195 ? -34.541 30.199  -9.661  0.80  51.66 ? 195  GLU A CD  1 
ATOM   1480 O OE1 . GLU A 1 195 ? -34.387 29.882  -10.865 0.80  52.03 ? 195  GLU A OE1 1 
ATOM   1481 O OE2 . GLU A 1 195 ? -34.456 31.379  -9.254  0.80  52.09 ? 195  GLU A OE2 1 
ATOM   1482 N N   . ASP A 1 203 ? -39.943 22.719  -8.674  0.010 40.91 ? 203  ASP A N   1 
ATOM   1483 C CA  . ASP A 1 203 ? -39.116 23.852  -9.071  0.010 40.93 ? 203  ASP A CA  1 
ATOM   1484 C C   . ASP A 1 203 ? -39.891 24.822  -9.950  0.010 40.99 ? 203  ASP A C   1 
ATOM   1485 O O   . ASP A 1 203 ? -40.980 24.511  -10.434 0.010 40.98 ? 203  ASP A O   1 
ATOM   1486 C CB  . ASP A 1 203 ? -37.877 23.372  -9.830  0.010 40.90 ? 203  ASP A CB  1 
ATOM   1487 C CG  . ASP A 1 203 ? -37.014 22.437  -9.009  0.010 40.86 ? 203  ASP A CG  1 
ATOM   1488 O OD1 . ASP A 1 203 ? -37.017 22.560  -7.767  0.010 40.82 ? 203  ASP A OD1 1 
ATOM   1489 O OD2 . ASP A 1 203 ? -36.329 21.581  -9.608  0.010 40.83 ? 203  ASP A OD2 1 
ATOM   1490 N N   . ARG A 1 204 ? -39.182 25.922  -10.245 0.010 41.12 ? 204  ARG A N   1 
ATOM   1491 C CA  . ARG A 1 204 ? -39.638 27.025  -11.081 0.010 41.27 ? 204  ARG A CA  1 
ATOM   1492 C C   . ARG A 1 204 ? -38.657 27.300  -12.185 0.010 41.48 ? 204  ARG A C   1 
ATOM   1493 O O   . ARG A 1 204 ? -37.467 27.331  -11.973 0.010 41.47 ? 204  ARG A O   1 
ATOM   1494 C CB  . ARG A 1 204 ? -39.825 28.296  -10.243 0.010 41.23 ? 204  ARG A CB  1 
ATOM   1495 C CG  . ARG A 1 204 ? -38.564 29.146  -9.991  0.010 41.12 ? 204  ARG A CG  1 
ATOM   1496 C CD  . ARG A 1 204 ? -38.949 30.463  -9.334  0.010 40.95 ? 204  ARG A CD  1 
ATOM   1497 N NE  . ARG A 1 204 ? -37.844 31.403  -9.123  0.010 40.83 ? 204  ARG A NE  1 
ATOM   1498 C CZ  . ARG A 1 204 ? -37.943 32.542  -8.427  0.010 40.77 ? 204  ARG A CZ  1 
ATOM   1499 N NH1 . ARG A 1 204 ? -39.096 32.902  -7.870  0.010 40.73 ? 204  ARG A NH1 1 
ATOM   1500 N NH2 . ARG A 1 204 ? -36.895 33.334  -8.282  0.010 40.75 ? 204  ARG A NH2 1 
ATOM   1501 N N   . MET A 1 205 ? -39.168 27.536  -13.373 0.60  41.79 ? 205  MET A N   1 
ATOM   1502 C CA  . MET A 1 205 ? -38.256 27.676  -14.498 0.60  42.18 ? 205  MET A CA  1 
ATOM   1503 C C   . MET A 1 205 ? -38.050 29.138  -14.886 0.60  42.63 ? 205  MET A C   1 
ATOM   1504 O O   . MET A 1 205 ? -38.964 29.777  -15.415 0.60  42.80 ? 205  MET A O   1 
ATOM   1505 C CB  . MET A 1 205 ? -38.795 26.908  -15.717 0.60  42.16 ? 205  MET A CB  1 
ATOM   1506 C CG  . MET A 1 205 ? -38.353 25.453  -15.849 0.60  42.17 ? 205  MET A CG  1 
ATOM   1507 S SD  . MET A 1 205 ? -38.839 24.767  -17.465 0.60  43.84 ? 205  MET A SD  1 
ATOM   1508 C CE  . MET A 1 205 ? -37.579 23.513  -17.716 0.60  43.11 ? 205  MET A CE  1 
ATOM   1509 N N   . VAL A 1 206 ? -36.843 29.651  -14.647 1.00  43.05 ? 206  VAL A N   1 
ATOM   1510 C CA  . VAL A 1 206 ? -36.465 31.007  -15.081 1.00  43.69 ? 206  VAL A CA  1 
ATOM   1511 C C   . VAL A 1 206 ? -36.039 31.049  -16.565 1.00  44.02 ? 206  VAL A C   1 
ATOM   1512 O O   . VAL A 1 206 ? -35.328 30.169  -17.031 1.00  44.10 ? 206  VAL A O   1 
ATOM   1513 C CB  . VAL A 1 206 ? -35.336 31.580  -14.171 1.00  43.65 ? 206  VAL A CB  1 
ATOM   1514 C CG1 . VAL A 1 206 ? -34.591 32.745  -14.833 1.00  44.00 ? 206  VAL A CG1 1 
ATOM   1515 C CG2 . VAL A 1 206 ? -35.901 32.014  -12.848 1.00  43.74 ? 206  VAL A CG2 1 
ATOM   1516 N N   . LEU A 1 207 ? -36.472 32.072  -17.293 1.00  44.59 ? 207  LEU A N   1 
ATOM   1517 C CA  . LEU A 1 207 ? -35.991 32.299  -18.650 1.00  45.35 ? 207  LEU A CA  1 
ATOM   1518 C C   . LEU A 1 207 ? -35.285 33.649  -18.755 1.00  46.02 ? 207  LEU A C   1 
ATOM   1519 O O   . LEU A 1 207 ? -35.840 34.680  -18.353 1.00  46.33 ? 207  LEU A O   1 
ATOM   1520 C CB  . LEU A 1 207 ? -37.155 32.254  -19.652 1.00  45.42 ? 207  LEU A CB  1 
ATOM   1521 C CG  . LEU A 1 207 ? -36.880 32.564  -21.131 1.00  45.13 ? 207  LEU A CG  1 
ATOM   1522 C CD1 . LEU A 1 207 ? -37.981 32.006  -21.985 1.00  46.02 ? 207  LEU A CD1 1 
ATOM   1523 C CD2 . LEU A 1 207 ? -36.744 34.047  -21.388 1.00  45.15 ? 207  LEU A CD2 1 
ATOM   1524 N N   . VAL A 1 208 ? -34.082 33.644  -19.327 1.00  46.62 ? 208  VAL A N   1 
ATOM   1525 C CA  . VAL A 1 208 ? -33.352 34.886  -19.615 1.00  47.19 ? 208  VAL A CA  1 
ATOM   1526 C C   . VAL A 1 208 ? -33.235 35.139  -21.130 1.00  47.93 ? 208  VAL A C   1 
ATOM   1527 O O   . VAL A 1 208 ? -32.883 34.236  -21.879 1.00  48.35 ? 208  VAL A O   1 
ATOM   1528 C CB  . VAL A 1 208 ? -31.951 34.916  -18.913 1.00  47.12 ? 208  VAL A CB  1 
ATOM   1529 C CG1 . VAL A 1 208 ? -32.108 34.767  -17.405 1.00  46.48 ? 208  VAL A CG1 1 
ATOM   1530 C CG2 . VAL A 1 208 ? -31.019 33.838  -19.457 1.00  46.63 ? 208  VAL A CG2 1 
ATOM   1531 N N   . GLY A 1 209 ? -33.545 36.355  -21.574 1.00  48.75 ? 209  GLY A N   1 
ATOM   1532 C CA  . GLY A 1 209 ? -33.471 36.716  -22.999 1.00  49.63 ? 209  GLY A CA  1 
ATOM   1533 C C   . GLY A 1 209 ? -34.849 36.896  -23.614 1.00  50.33 ? 209  GLY A C   1 
ATOM   1534 O O   . GLY A 1 209 ? -35.814 36.315  -23.125 1.00  50.35 ? 209  GLY A O   1 
ATOM   1535 N N   . ASP A 1 210 ? -34.943 37.689  -24.688 1.00  51.02 ? 210  ASP A N   1 
ATOM   1536 C CA  . ASP A 1 210 ? -36.248 38.070  -25.262 1.00  51.55 ? 210  ASP A CA  1 
ATOM   1537 C C   . ASP A 1 210 ? -36.850 37.002  -26.175 1.00  51.59 ? 210  ASP A C   1 
ATOM   1538 O O   . ASP A 1 210 ? -36.199 36.544  -27.111 1.00  51.70 ? 210  ASP A O   1 
ATOM   1539 C CB  . ASP A 1 210 ? -36.170 39.411  -26.011 1.00  51.60 ? 210  ASP A CB  1 
ATOM   1540 C CG  . ASP A 1 210 ? -37.561 39.973  -26.348 1.00  53.34 ? 210  ASP A CG  1 
ATOM   1541 O OD1 . ASP A 1 210 ? -38.483 39.832  -25.502 1.00  54.20 ? 210  ASP A OD1 1 
ATOM   1542 O OD2 . ASP A 1 210 ? -37.736 40.557  -27.452 1.00  53.93 ? 210  ASP A OD2 1 
ATOM   1543 N N   . VAL A 1 211 ? -38.099 36.624  -25.902 1.00  51.76 ? 211  VAL A N   1 
ATOM   1544 C CA  . VAL A 1 211 ? -38.825 35.667  -26.753 1.00  52.08 ? 211  VAL A CA  1 
ATOM   1545 C C   . VAL A 1 211 ? -40.255 36.125  -27.064 1.00  52.19 ? 211  VAL A C   1 
ATOM   1546 O O   . VAL A 1 211 ? -41.047 35.361  -27.632 1.00  52.59 ? 211  VAL A O   1 
ATOM   1547 C CB  . VAL A 1 211 ? -38.858 34.220  -26.148 1.00  52.14 ? 211  VAL A CB  1 
ATOM   1548 C CG1 . VAL A 1 211 ? -37.443 33.690  -25.896 1.00  51.95 ? 211  VAL A CG1 1 
ATOM   1549 C CG2 . VAL A 1 211 ? -39.685 34.174  -24.860 1.00  52.80 ? 211  VAL A CG2 1 
ATOM   1550 N N   . LYS A 1 212 ? -40.576 37.361  -26.687 0.40  51.99 ? 212  LYS A N   1 
ATOM   1551 C CA  . LYS A 1 212 ? -41.908 37.916  -26.883 0.40  51.79 ? 212  LYS A CA  1 
ATOM   1552 C C   . LYS A 1 212 ? -42.185 38.117  -28.372 0.40  51.71 ? 212  LYS A C   1 
ATOM   1553 O O   . LYS A 1 212 ? -41.386 38.741  -29.074 0.40  51.64 ? 212  LYS A O   1 
ATOM   1554 C CB  . LYS A 1 212 ? -42.037 39.241  -26.127 0.40  51.89 ? 212  LYS A CB  1 
ATOM   1555 C CG  . LYS A 1 212 ? -43.465 39.667  -25.826 0.40  52.38 ? 212  LYS A CG  1 
ATOM   1556 C CD  . LYS A 1 212 ? -44.060 38.856  -24.679 0.40  52.70 ? 212  LYS A CD  1 
ATOM   1557 C CE  . LYS A 1 212 ? -45.529 39.211  -24.449 0.40  52.88 ? 212  LYS A CE  1 
ATOM   1558 N NZ  . LYS A 1 212 ? -46.115 38.427  -23.323 0.40  52.52 ? 212  LYS A NZ  1 
ATOM   1559 N N   . ASP A 1 213 ? -43.302 37.549  -28.838 1.00  51.79 ? 213  ASP A N   1 
ATOM   1560 C CA  . ASP A 1 213 ? -43.833 37.732  -30.209 1.00  51.81 ? 213  ASP A CA  1 
ATOM   1561 C C   . ASP A 1 213 ? -42.968 37.156  -31.323 1.00  51.67 ? 213  ASP A C   1 
ATOM   1562 O O   . ASP A 1 213 ? -43.032 37.622  -32.461 1.00  52.41 ? 213  ASP A O   1 
ATOM   1563 C CB  . ASP A 1 213 ? -44.121 39.213  -30.522 1.00  51.69 ? 213  ASP A CB  1 
ATOM   1564 C CG  . ASP A 1 213 ? -44.927 39.900  -29.438 1.00  52.67 ? 213  ASP A CG  1 
ATOM   1565 O OD1 . ASP A 1 213 ? -44.911 41.159  -29.430 1.00  53.07 ? 213  ASP A OD1 1 
ATOM   1566 O OD2 . ASP A 1 213 ? -45.561 39.199  -28.597 1.00  52.93 ? 213  ASP A OD2 1 
ATOM   1567 N N   . ARG A 1 214 ? -42.158 36.156  -31.019 0.40  51.23 ? 214  ARG A N   1 
ATOM   1568 C CA  . ARG A 1 214 ? -41.271 35.617  -32.032 0.40  50.83 ? 214  ARG A CA  1 
ATOM   1569 C C   . ARG A 1 214 ? -41.218 34.106  -31.930 0.40  50.57 ? 214  ARG A C   1 
ATOM   1570 O O   . ARG A 1 214 ? -41.556 33.538  -30.888 0.40  50.45 ? 214  ARG A O   1 
ATOM   1571 C CB  . ARG A 1 214 ? -39.875 36.241  -31.902 0.40  50.92 ? 214  ARG A CB  1 
ATOM   1572 C CG  . ARG A 1 214 ? -39.312 36.207  -30.497 0.40  50.89 ? 214  ARG A CG  1 
ATOM   1573 C CD  . ARG A 1 214 ? -38.373 37.378  -30.236 0.40  51.45 ? 214  ARG A CD  1 
ATOM   1574 N NE  . ARG A 1 214 ? -37.075 37.235  -30.892 0.40  51.54 ? 214  ARG A NE  1 
ATOM   1575 C CZ  . ARG A 1 214 ? -36.665 37.987  -31.907 0.40  51.78 ? 214  ARG A CZ  1 
ATOM   1576 N NH1 . ARG A 1 214 ? -37.456 38.933  -32.391 0.40  52.33 ? 214  ARG A NH1 1 
ATOM   1577 N NH2 . ARG A 1 214 ? -35.468 37.786  -32.444 0.40  51.66 ? 214  ARG A NH2 1 
ATOM   1578 N N   . VAL A 1 215 ? -40.802 33.453  -33.011 1.00  50.34 ? 215  VAL A N   1 
ATOM   1579 C CA  . VAL A 1 215 ? -40.692 31.999  -33.003 1.00  50.04 ? 215  VAL A CA  1 
ATOM   1580 C C   . VAL A 1 215 ? -39.614 31.617  -32.000 1.00  49.95 ? 215  VAL A C   1 
ATOM   1581 O O   . VAL A 1 215 ? -38.603 32.309  -31.875 1.00  50.29 ? 215  VAL A O   1 
ATOM   1582 C CB  . VAL A 1 215 ? -40.325 31.428  -34.379 1.00  50.07 ? 215  VAL A CB  1 
ATOM   1583 C CG1 . VAL A 1 215 ? -40.717 29.950  -34.454 1.00  49.95 ? 215  VAL A CG1 1 
ATOM   1584 C CG2 . VAL A 1 215 ? -40.993 32.217  -35.494 1.00  50.17 ? 215  VAL A CG2 1 
ATOM   1585 N N   . ALA A 1 216 ? -39.828 30.524  -31.280 1.00  49.63 ? 216  ALA A N   1 
ATOM   1586 C CA  . ALA A 1 216 ? -38.864 30.096  -30.279 1.00  49.29 ? 216  ALA A CA  1 
ATOM   1587 C C   . ALA A 1 216 ? -38.465 28.643  -30.474 1.00  49.18 ? 216  ALA A C   1 
ATOM   1588 O O   . ALA A 1 216 ? -39.212 27.725  -30.113 1.00  48.76 ? 216  ALA A O   1 
ATOM   1589 C CB  . ALA A 1 216 ? -39.419 30.313  -28.883 1.00  49.54 ? 216  ALA A CB  1 
ATOM   1590 N N   . ILE A 1 217 ? -37.279 28.439  -31.040 1.00  49.06 ? 217  ILE A N   1 
ATOM   1591 C CA  . ILE A 1 217 ? -36.785 27.089  -31.266 1.00  49.12 ? 217  ILE A CA  1 
ATOM   1592 C C   . ILE A 1 217 ? -35.913 26.630  -30.095 1.00  49.30 ? 217  ILE A C   1 
ATOM   1593 O O   . ILE A 1 217 ? -34.856 27.213  -29.826 1.00  49.51 ? 217  ILE A O   1 
ATOM   1594 C CB  . ILE A 1 217 ? -35.987 26.976  -32.589 1.00  49.11 ? 217  ILE A CB  1 
ATOM   1595 C CG1 . ILE A 1 217 ? -36.696 27.709  -33.727 1.00  49.06 ? 217  ILE A CG1 1 
ATOM   1596 C CG2 . ILE A 1 217 ? -35.755 25.512  -32.949 1.00  48.74 ? 217  ILE A CG2 1 
ATOM   1597 C CD1 . ILE A 1 217 ? -35.737 28.142  -34.838 1.00  50.16 ? 217  ILE A CD1 1 
ATOM   1598 N N   . LEU A 1 218 ? -36.367 25.593  -29.396 1.00  49.32 ? 218  LEU A N   1 
ATOM   1599 C CA  . LEU A 1 218 ? -35.565 24.946  -28.358 1.00  49.47 ? 218  LEU A CA  1 
ATOM   1600 C C   . LEU A 1 218 ? -34.580 23.987  -28.996 1.00  49.72 ? 218  LEU A C   1 
ATOM   1601 O O   . LEU A 1 218 ? -34.984 23.040  -29.665 1.00  49.73 ? 218  LEU A O   1 
ATOM   1602 C CB  . LEU A 1 218 ? -36.442 24.155  -27.383 1.00  49.30 ? 218  LEU A CB  1 
ATOM   1603 C CG  . LEU A 1 218 ? -36.946 24.811  -26.096 1.00  49.81 ? 218  LEU A CG  1 
ATOM   1604 C CD1 . LEU A 1 218 ? -38.090 24.001  -25.499 1.00  50.93 ? 218  LEU A CD1 1 
ATOM   1605 C CD2 . LEU A 1 218 ? -35.845 24.979  -25.071 1.00  49.55 ? 218  LEU A CD2 1 
ATOM   1606 N N   . VAL A 1 219 ? -33.290 24.223  -28.785 1.00  50.32 ? 219  VAL A N   1 
ATOM   1607 C CA  . VAL A 1 219 ? -32.261 23.289  -29.254 1.00  50.80 ? 219  VAL A CA  1 
ATOM   1608 C C   . VAL A 1 219 ? -31.562 22.619  -28.085 1.00  51.36 ? 219  VAL A C   1 
ATOM   1609 O O   . VAL A 1 219 ? -31.062 23.283  -27.182 1.00  51.37 ? 219  VAL A O   1 
ATOM   1610 C CB  . VAL A 1 219 ? -31.209 23.962  -30.172 1.00  50.71 ? 219  VAL A CB  1 
ATOM   1611 C CG1 . VAL A 1 219 ? -30.019 23.018  -30.407 1.00  50.45 ? 219  VAL A CG1 1 
ATOM   1612 C CG2 . VAL A 1 219 ? -31.847 24.354  -31.517 1.00  51.00 ? 219  VAL A CG2 1 
ATOM   1613 N N   . ASP A 1 220 ? -31.548 21.292  -28.114 1.00  52.20 ? 220  ASP A N   1 
ATOM   1614 C CA  . ASP A 1 220 ? -30.788 20.492  -27.165 1.00  53.16 ? 220  ASP A CA  1 
ATOM   1615 C C   . ASP A 1 220 ? -30.085 19.358  -27.926 1.00  53.81 ? 220  ASP A C   1 
ATOM   1616 O O   . ASP A 1 220 ? -30.522 18.972  -29.009 1.00  54.01 ? 220  ASP A O   1 
ATOM   1617 C CB  . ASP A 1 220 ? -31.733 19.939  -26.099 1.00  53.18 ? 220  ASP A CB  1 
ATOM   1618 C CG  . ASP A 1 220 ? -31.002 19.411  -24.866 1.00  53.94 ? 220  ASP A CG  1 
ATOM   1619 O OD1 . ASP A 1 220 ? -29.789 19.689  -24.675 1.00  54.83 ? 220  ASP A OD1 1 
ATOM   1620 O OD2 . ASP A 1 220 ? -31.658 18.704  -24.073 1.00  54.26 ? 220  ASP A OD2 1 
ATOM   1621 N N   . ASP A 1 221 ? -28.991 18.833  -27.384 1.00  54.77 ? 221  ASP A N   1 
ATOM   1622 C CA  . ASP A 1 221 ? -28.280 17.747  -28.070 1.00  55.91 ? 221  ASP A CA  1 
ATOM   1623 C C   . ASP A 1 221 ? -29.046 16.445  -27.917 1.00  56.48 ? 221  ASP A C   1 
ATOM   1624 O O   . ASP A 1 221 ? -28.951 15.552  -28.768 1.00  56.72 ? 221  ASP A O   1 
ATOM   1625 C CB  . ASP A 1 221 ? -26.848 17.572  -27.548 1.00  55.93 ? 221  ASP A CB  1 
ATOM   1626 C CG  . ASP A 1 221 ? -26.804 17.371  -26.049 1.00  57.02 ? 221  ASP A CG  1 
ATOM   1627 O OD1 . ASP A 1 221 ? -26.455 16.250  -25.595 1.00  56.76 ? 221  ASP A OD1 1 
ATOM   1628 O OD2 . ASP A 1 221 ? -27.156 18.340  -25.328 1.00  57.92 ? 221  ASP A OD2 1 
ATOM   1629 N N   . MET A 1 222 ? -29.813 16.363  -26.827 0.81  57.20 ? 222  MET A N   1 
ATOM   1630 C CA  . MET A 1 222 ? -30.513 15.142  -26.431 0.81  58.03 ? 222  MET A CA  1 
ATOM   1631 C C   . MET A 1 222 ? -31.885 15.414  -25.795 0.81  58.61 ? 222  MET A C   1 
ATOM   1632 O O   . MET A 1 222 ? -32.112 16.469  -25.191 0.81  58.83 ? 222  MET A O   1 
ATOM   1633 C CB  . MET A 1 222 ? -29.649 14.337  -25.448 0.81  58.16 ? 222  MET A CB  1 
ATOM   1634 C CG  . MET A 1 222 ? -29.647 14.850  -23.993 0.81  58.38 ? 222  MET A CG  1 
ATOM   1635 S SD  . MET A 1 222 ? -28.790 16.437  -23.766 0.81  59.10 ? 222  MET A SD  1 
ATOM   1636 C CE  . MET A 1 222 ? -28.818 16.600  -21.949 0.81  58.02 ? 222  MET A CE  1 
ATOM   1637 N N   . ALA A 1 223 ? -32.795 14.453  -25.945 1.00  59.20 ? 223  ALA A N   1 
ATOM   1638 C CA  . ALA A 1 223 ? -34.055 14.432  -25.200 1.00  59.65 ? 223  ALA A CA  1 
ATOM   1639 C C   . ALA A 1 223 ? -34.241 13.016  -24.700 1.00  60.16 ? 223  ALA A C   1 
ATOM   1640 O O   . ALA A 1 223 ? -33.935 12.057  -25.420 1.00  60.08 ? 223  ALA A O   1 
ATOM   1641 C CB  . ALA A 1 223 ? -35.210 14.815  -26.080 1.00  59.52 ? 223  ALA A CB  1 
ATOM   1642 N N   . ASP A 1 224 ? -34.729 12.869  -23.469 1.00  60.80 ? 224  ASP A N   1 
ATOM   1643 C CA  . ASP A 1 224 ? -34.868 11.530  -22.895 1.00  61.39 ? 224  ASP A CA  1 
ATOM   1644 C C   . ASP A 1 224 ? -36.273 11.190  -22.407 1.00  61.66 ? 224  ASP A C   1 
ATOM   1645 O O   . ASP A 1 224 ? -36.872 10.220  -22.878 1.00  61.91 ? 224  ASP A O   1 
ATOM   1646 C CB  . ASP A 1 224 ? -33.852 11.294  -21.785 1.00  61.42 ? 224  ASP A CB  1 
ATOM   1647 C CG  . ASP A 1 224 ? -33.813 9.840   -21.344 1.00  62.95 ? 224  ASP A CG  1 
ATOM   1648 O OD1 . ASP A 1 224 ? -33.917 8.947   -22.226 1.00  63.60 ? 224  ASP A OD1 1 
ATOM   1649 O OD2 . ASP A 1 224 ? -33.682 9.591   -20.118 1.00  63.93 ? 224  ASP A OD2 1 
ATOM   1650 N N   . THR A 1 225 ? -36.774 11.967  -21.448 1.00  61.94 ? 225  THR A N   1 
ATOM   1651 C CA  . THR A 1 225 ? -38.174 11.879  -21.000 1.00  62.12 ? 225  THR A CA  1 
ATOM   1652 C C   . THR A 1 225 ? -38.960 13.036  -21.596 1.00  62.27 ? 225  THR A C   1 
ATOM   1653 O O   . THR A 1 225 ? -40.197 13.050  -21.533 1.00  62.51 ? 225  THR A O   1 
ATOM   1654 C CB  . THR A 1 225 ? -38.344 12.002  -19.453 1.00  62.15 ? 225  THR A CB  1 
ATOM   1655 O OG1 . THR A 1 225 ? -38.228 13.383  -19.056 1.00  62.24 ? 225  THR A OG1 1 
ATOM   1656 C CG2 . THR A 1 225 ? -37.327 11.122  -18.684 1.00  62.56 ? 225  THR A CG2 1 
ATOM   1657 N N   . CYS A 1 226 ? -38.233 14.014  -22.140 0.010 62.13 ? 226  CYS A N   1 
ATOM   1658 C CA  . CYS A 1 226 ? -38.818 15.267  -22.628 0.010 62.16 ? 226  CYS A CA  1 
ATOM   1659 C C   . CYS A 1 226 ? -39.499 16.093  -21.528 0.010 61.50 ? 226  CYS A C   1 
ATOM   1660 O O   . CYS A 1 226 ? -40.294 16.984  -21.826 0.010 61.35 ? 226  CYS A O   1 
ATOM   1661 C CB  . CYS A 1 226 ? -39.779 15.007  -23.798 0.010 62.37 ? 226  CYS A CB  1 
ATOM   1662 S SG  . CYS A 1 226 ? -38.935 14.522  -25.339 0.010 65.37 ? 226  CYS A SG  1 
ATOM   1663 N N   . GLY A 1 227 ? -39.174 15.796  -20.264 1.00  60.99 ? 227  GLY A N   1 
ATOM   1664 C CA  . GLY A 1 227 ? -39.745 16.504  -19.109 1.00  60.23 ? 227  GLY A CA  1 
ATOM   1665 C C   . GLY A 1 227 ? -39.347 17.971  -19.074 1.00  59.69 ? 227  GLY A C   1 
ATOM   1666 O O   . GLY A 1 227 ? -40.203 18.871  -18.988 1.00  59.89 ? 227  GLY A O   1 
ATOM   1667 N N   . THR A 1 228 ? -38.038 18.194  -19.155 1.00  58.92 ? 228  THR A N   1 
ATOM   1668 C CA  . THR A 1 228 ? -37.439 19.523  -19.197 1.00  58.19 ? 228  THR A CA  1 
ATOM   1669 C C   . THR A 1 228 ? -37.823 20.238  -20.492 1.00  57.88 ? 228  THR A C   1 
ATOM   1670 O O   . THR A 1 228 ? -38.099 21.438  -20.480 1.00  57.70 ? 228  THR A O   1 
ATOM   1671 C CB  . THR A 1 228 ? -35.877 19.431  -19.063 1.00  58.15 ? 228  THR A CB  1 
ATOM   1672 O OG1 . THR A 1 228 ? -35.537 18.678  -17.890 1.00  58.31 ? 228  THR A OG1 1 
ATOM   1673 C CG2 . THR A 1 228 ? -35.220 20.816  -18.989 1.00  57.62 ? 228  THR A CG2 1 
ATOM   1674 N N   . ILE A 1 229 ? -37.860 19.499  -21.600 1.00  57.79 ? 229  ILE A N   1 
ATOM   1675 C CA  . ILE A 1 229 ? -38.115 20.121  -22.901 1.00  57.95 ? 229  ILE A CA  1 
ATOM   1676 C C   . ILE A 1 229 ? -39.587 20.548  -23.096 1.00  57.94 ? 229  ILE A C   1 
ATOM   1677 O O   . ILE A 1 229 ? -39.861 21.588  -23.713 1.00  57.89 ? 229  ILE A O   1 
ATOM   1678 C CB  . ILE A 1 229 ? -37.562 19.281  -24.078 1.00  57.98 ? 229  ILE A CB  1 
ATOM   1679 C CG1 . ILE A 1 229 ? -37.057 20.222  -25.184 1.00  58.75 ? 229  ILE A CG1 1 
ATOM   1680 C CG2 . ILE A 1 229 ? -38.590 18.251  -24.566 1.00  57.83 ? 229  ILE A CG2 1 
ATOM   1681 C CD1 . ILE A 1 229 ? -36.813 19.535  -26.523 1.00  59.83 ? 229  ILE A CD1 1 
ATOM   1682 N N   . CYS A 1 230 ? -40.501 19.739  -22.544 1.00  58.12 ? 230  CYS A N   1 
ATOM   1683 C CA  . CYS A 1 230 ? -41.938 20.038  -22.452 1.00  58.30 ? 230  CYS A CA  1 
ATOM   1684 C C   . CYS A 1 230 ? -42.173 21.286  -21.610 1.00  57.76 ? 230  CYS A C   1 
ATOM   1685 O O   . CYS A 1 230 ? -42.758 22.271  -22.084 1.00  57.47 ? 230  CYS A O   1 
ATOM   1686 C CB  . CYS A 1 230 ? -42.702 18.858  -21.822 1.00  58.41 ? 230  CYS A CB  1 
ATOM   1687 S SG  . CYS A 1 230 ? -43.331 17.581  -22.984 1.00  61.82 ? 230  CYS A SG  1 
ATOM   1688 N N   . HIS A 1 231 ? -41.716 21.237  -20.359 1.00  57.37 ? 231  HIS A N   1 
ATOM   1689 C CA  . HIS A 1 231 ? -41.820 22.395  -19.482 1.00  57.65 ? 231  HIS A CA  1 
ATOM   1690 C C   . HIS A 1 231 ? -41.254 23.643  -20.155 1.00  57.22 ? 231  HIS A C   1 
ATOM   1691 O O   . HIS A 1 231 ? -41.890 24.705  -20.157 1.00  57.31 ? 231  HIS A O   1 
ATOM   1692 C CB  . HIS A 1 231 ? -41.099 22.166  -18.151 1.00  57.88 ? 231  HIS A CB  1 
ATOM   1693 C CG  . HIS A 1 231 ? -41.818 21.244  -17.221 1.00  59.50 ? 231  HIS A CG  1 
ATOM   1694 N ND1 . HIS A 1 231 ? -43.156 20.935  -17.358 1.00  60.83 ? 231  HIS A ND1 1 
ATOM   1695 C CD2 . HIS A 1 231 ? -41.391 20.587  -16.115 1.00  60.92 ? 231  HIS A CD2 1 
ATOM   1696 C CE1 . HIS A 1 231 ? -43.516 20.104  -16.396 1.00  61.13 ? 231  HIS A CE1 1 
ATOM   1697 N NE2 . HIS A 1 231 ? -42.464 19.880  -15.625 1.00  62.03 ? 231  HIS A NE2 1 
ATOM   1698 N N   . ALA A 1 232 ? -40.059 23.507  -20.728 1.00  56.40 ? 232  ALA A N   1 
ATOM   1699 C CA  . ALA A 1 232 ? -39.397 24.630  -21.366 1.00  55.89 ? 232  ALA A CA  1 
ATOM   1700 C C   . ALA A 1 232 ? -40.348 25.294  -22.348 1.00  55.64 ? 232  ALA A C   1 
ATOM   1701 O O   . ALA A 1 232 ? -40.485 26.519  -22.338 1.00  55.63 ? 232  ALA A O   1 
ATOM   1702 C CB  . ALA A 1 232 ? -38.122 24.180  -22.056 1.00  56.00 ? 232  ALA A CB  1 
ATOM   1703 N N   . ALA A 1 233 ? -41.023 24.475  -23.161 1.00  55.24 ? 233  ALA A N   1 
ATOM   1704 C CA  . ALA A 1 233 ? -42.008 24.958  -24.129 1.00  54.88 ? 233  ALA A CA  1 
ATOM   1705 C C   . ALA A 1 233 ? -43.152 25.731  -23.461 1.00  54.93 ? 233  ALA A C   1 
ATOM   1706 O O   . ALA A 1 233 ? -43.600 26.761  -23.996 1.00  55.15 ? 233  ALA A O   1 
ATOM   1707 C CB  . ALA A 1 233 ? -42.549 23.813  -24.941 1.00  54.84 ? 233  ALA A CB  1 
ATOM   1708 N N   . ASP A 1 234 ? -43.613 25.228  -22.305 1.00  54.53 ? 234  ASP A N   1 
ATOM   1709 C CA  . ASP A 1 234 ? -44.620 25.899  -21.474 1.00  54.22 ? 234  ASP A CA  1 
ATOM   1710 C C   . ASP A 1 234 ? -44.175 27.311  -21.267 1.00  53.79 ? 234  ASP A C   1 
ATOM   1711 O O   . ASP A 1 234 ? -44.773 28.265  -21.763 1.00  53.90 ? 234  ASP A O   1 
ATOM   1712 C CB  . ASP A 1 234 ? -44.664 25.303  -20.063 1.00  54.42 ? 234  ASP A CB  1 
ATOM   1713 C CG  . ASP A 1 234 ? -45.449 24.016  -19.969 1.00  55.77 ? 234  ASP A CG  1 
ATOM   1714 O OD1 . ASP A 1 234 ? -45.820 23.424  -21.010 1.00  58.11 ? 234  ASP A OD1 1 
ATOM   1715 O OD2 . ASP A 1 234 ? -45.690 23.583  -18.820 1.00  55.87 ? 234  ASP A OD2 1 
ATOM   1716 N N   . LYS A 1 235 ? -43.097 27.411  -20.500 1.00  53.38 ? 235  LYS A N   1 
ATOM   1717 C CA  . LYS A 1 235 ? -42.551 28.674  -20.075 1.00  53.02 ? 235  LYS A CA  1 
ATOM   1718 C C   . LYS A 1 235 ? -42.410 29.610  -21.277 1.00  52.63 ? 235  LYS A C   1 
ATOM   1719 O O   . LYS A 1 235 ? -42.754 30.792  -21.190 1.00  52.59 ? 235  LYS A O   1 
ATOM   1720 C CB  . LYS A 1 235 ? -41.214 28.444  -19.364 1.00  53.12 ? 235  LYS A CB  1 
ATOM   1721 C CG  . LYS A 1 235 ? -41.044 29.220  -18.058 1.00  54.22 ? 235  LYS A CG  1 
ATOM   1722 C CD  . LYS A 1 235 ? -40.957 30.733  -18.294 1.00  56.04 ? 235  LYS A CD  1 
ATOM   1723 C CE  . LYS A 1 235 ? -40.649 31.484  -17.010 1.00  56.75 ? 235  LYS A CE  1 
ATOM   1724 N NZ  . LYS A 1 235 ? -40.174 32.888  -17.259 1.00  58.12 ? 235  LYS A NZ  1 
ATOM   1725 N N   . LEU A 1 236 ? -41.948 29.067  -22.405 1.00  52.13 ? 236  LEU A N   1 
ATOM   1726 C CA  . LEU A 1 236 ? -41.796 29.845  -23.634 1.00  51.68 ? 236  LEU A CA  1 
ATOM   1727 C C   . LEU A 1 236 ? -43.131 30.414  -24.140 1.00  51.43 ? 236  LEU A C   1 
ATOM   1728 O O   . LEU A 1 236 ? -43.170 31.494  -24.738 1.00  51.27 ? 236  LEU A O   1 
ATOM   1729 C CB  . LEU A 1 236 ? -41.125 29.007  -24.731 1.00  51.79 ? 236  LEU A CB  1 
ATOM   1730 C CG  . LEU A 1 236 ? -39.735 28.365  -24.571 1.00  51.43 ? 236  LEU A CG  1 
ATOM   1731 C CD1 . LEU A 1 236 ? -39.338 27.697  -25.879 1.00  50.66 ? 236  LEU A CD1 1 
ATOM   1732 C CD2 . LEU A 1 236 ? -38.659 29.344  -24.134 1.00  50.66 ? 236  LEU A CD2 1 
ATOM   1733 N N   . LEU A 1 237 ? -44.221 29.688  -23.912 1.00  51.10 ? 237  LEU A N   1 
ATOM   1734 C CA  . LEU A 1 237 ? -45.534 30.224  -24.247 1.00  51.08 ? 237  LEU A CA  1 
ATOM   1735 C C   . LEU A 1 237 ? -45.900 31.362  -23.281 1.00  51.02 ? 237  LEU A C   1 
ATOM   1736 O O   . LEU A 1 237 ? -46.223 32.473  -23.715 1.00  50.96 ? 237  LEU A O   1 
ATOM   1737 C CB  . LEU A 1 237 ? -46.605 29.130  -24.247 1.00  51.17 ? 237  LEU A CB  1 
ATOM   1738 C CG  . LEU A 1 237 ? -46.771 28.191  -25.444 1.00  51.19 ? 237  LEU A CG  1 
ATOM   1739 C CD1 . LEU A 1 237 ? -48.172 27.582  -25.389 1.00  51.83 ? 237  LEU A CD1 1 
ATOM   1740 C CD2 . LEU A 1 237 ? -46.567 28.886  -26.780 1.00  51.54 ? 237  LEU A CD2 1 
ATOM   1741 N N   . SER A 1 238 ? -45.823 31.077  -21.979 1.00  50.77 ? 238  SER A N   1 
ATOM   1742 C CA  . SER A 1 238 ? -45.997 32.074  -20.905 1.00  50.79 ? 238  SER A CA  1 
ATOM   1743 C C   . SER A 1 238 ? -45.260 33.404  -21.147 1.00  50.91 ? 238  SER A C   1 
ATOM   1744 O O   . SER A 1 238 ? -45.750 34.477  -20.787 1.00  50.97 ? 238  SER A O   1 
ATOM   1745 C CB  . SER A 1 238 ? -45.521 31.487  -19.577 1.00  50.71 ? 238  SER A CB  1 
ATOM   1746 O OG  . SER A 1 238 ? -45.536 30.068  -19.626 1.00  50.77 ? 238  SER A OG  1 
ATOM   1747 N N   . ALA A 1 239 ? -44.074 33.321  -21.742 1.00  51.05 ? 239  ALA A N   1 
ATOM   1748 C CA  . ALA A 1 239 ? -43.333 34.504  -22.139 1.00  51.17 ? 239  ALA A CA  1 
ATOM   1749 C C   . ALA A 1 239 ? -43.618 34.878  -23.601 1.00  51.49 ? 239  ALA A C   1 
ATOM   1750 O O   . ALA A 1 239 ? -42.795 35.540  -24.253 1.00  52.02 ? 239  ALA A O   1 
ATOM   1751 C CB  . ALA A 1 239 ? -41.842 34.291  -21.906 1.00  51.20 ? 239  ALA A CB  1 
ATOM   1752 N N   . GLY A 1 240 ? -44.769 34.445  -24.117 1.00  51.40 ? 240  GLY A N   1 
ATOM   1753 C CA  . GLY A 1 240 ? -45.302 34.983  -25.376 1.00  51.92 ? 240  GLY A CA  1 
ATOM   1754 C C   . GLY A 1 240 ? -44.466 34.750  -26.625 1.00  52.36 ? 240  GLY A C   1 
ATOM   1755 O O   . GLY A 1 240 ? -44.223 35.675  -27.418 1.00  52.59 ? 240  GLY A O   1 
ATOM   1756 N N   . ALA A 1 241 ? -44.008 33.515  -26.795 1.00  52.33 ? 241  ALA A N   1 
ATOM   1757 C CA  . ALA A 1 241 ? -43.439 33.112  -28.054 1.00  52.34 ? 241  ALA A CA  1 
ATOM   1758 C C   . ALA A 1 241 ? -44.623 32.788  -28.937 1.00  52.55 ? 241  ALA A C   1 
ATOM   1759 O O   . ALA A 1 241 ? -45.602 32.199  -28.471 1.00  52.30 ? 241  ALA A O   1 
ATOM   1760 C CB  . ALA A 1 241 ? -42.565 31.892  -27.882 1.00  52.44 ? 241  ALA A CB  1 
ATOM   1761 N N   . THR A 1 242 ? -44.535 33.196  -30.201 1.00  52.93 ? 242  THR A N   1 
ATOM   1762 C CA  . THR A 1 242 ? -45.571 32.922  -31.168 1.00  53.14 ? 242  THR A CA  1 
ATOM   1763 C C   . THR A 1 242 ? -45.756 31.411  -31.289 1.00  53.51 ? 242  THR A C   1 
ATOM   1764 O O   . THR A 1 242 ? -46.828 30.883  -30.982 1.00  53.94 ? 242  THR A O   1 
ATOM   1765 C CB  . THR A 1 242 ? -45.263 33.584  -32.516 1.00  53.27 ? 242  THR A CB  1 
ATOM   1766 O OG1 . THR A 1 242 ? -45.437 35.009  -32.392 1.00  53.62 ? 242  THR A OG1 1 
ATOM   1767 C CG2 . THR A 1 242 ? -46.192 33.035  -33.613 1.00  52.97 ? 242  THR A CG2 1 
ATOM   1768 N N   . ARG A 1 243 ? -44.700 30.712  -31.692 1.00  53.81 ? 243  ARG A N   1 
ATOM   1769 C CA  . ARG A 1 243 ? -44.735 29.249  -31.837 1.00  53.83 ? 243  ARG A CA  1 
ATOM   1770 C C   . ARG A 1 243 ? -43.462 28.627  -31.233 1.00  53.45 ? 243  ARG A C   1 
ATOM   1771 O O   . ARG A 1 243 ? -42.408 29.275  -31.188 1.00  53.74 ? 243  ARG A O   1 
ATOM   1772 C CB  . ARG A 1 243 ? -44.915 28.865  -33.316 1.00  53.91 ? 243  ARG A CB  1 
ATOM   1773 C CG  . ARG A 1 243 ? -46.284 29.294  -33.888 1.00  56.13 ? 243  ARG A CG  1 
ATOM   1774 C CD  . ARG A 1 243 ? -46.424 29.147  -35.414 1.00  58.90 ? 243  ARG A CD  1 
ATOM   1775 N NE  . ARG A 1 243 ? -45.337 29.788  -36.151 1.00  61.56 ? 243  ARG A NE  1 
ATOM   1776 C CZ  . ARG A 1 243 ? -44.450 29.127  -36.894 1.00  63.12 ? 243  ARG A CZ  1 
ATOM   1777 N NH1 . ARG A 1 243 ? -44.543 27.808  -37.013 1.00  63.48 ? 243  ARG A NH1 1 
ATOM   1778 N NH2 . ARG A 1 243 ? -43.482 29.781  -37.529 1.00  62.94 ? 243  ARG A NH2 1 
ATOM   1779 N N   . VAL A 1 244 ? -43.548 27.388  -30.754 1.00  52.73 ? 244  VAL A N   1 
ATOM   1780 C CA  . VAL A 1 244 ? -42.357 26.746  -30.189 1.00  52.36 ? 244  VAL A CA  1 
ATOM   1781 C C   . VAL A 1 244 ? -41.970 25.399  -30.823 1.00  52.12 ? 244  VAL A C   1 
ATOM   1782 O O   . VAL A 1 244 ? -42.723 24.421  -30.756 1.00  52.13 ? 244  VAL A O   1 
ATOM   1783 C CB  . VAL A 1 244 ? -42.397 26.661  -28.632 1.00  52.43 ? 244  VAL A CB  1 
ATOM   1784 C CG1 . VAL A 1 244 ? -43.807 26.394  -28.136 1.00  53.02 ? 244  VAL A CG1 1 
ATOM   1785 C CG2 . VAL A 1 244 ? -41.413 25.599  -28.104 1.00  52.32 ? 244  VAL A CG2 1 
ATOM   1786 N N   . TYR A 1 245 ? -40.785 25.379  -31.437 0.50  51.59 ? 245  TYR A N   1 
ATOM   1787 C CA  . TYR A 1 245 ? -40.193 24.168  -31.991 0.50  51.17 ? 245  TYR A CA  1 
ATOM   1788 C C   . TYR A 1 245 ? -39.148 23.613  -31.026 0.50  51.15 ? 245  TYR A C   1 
ATOM   1789 O O   . TYR A 1 245 ? -38.530 24.375  -30.284 0.50  51.07 ? 245  TYR A O   1 
ATOM   1790 C CB  . TYR A 1 245 ? -39.494 24.477  -33.315 0.50  51.04 ? 245  TYR A CB  1 
ATOM   1791 C CG  . TYR A 1 245 ? -40.381 24.935  -34.448 0.50  50.71 ? 245  TYR A CG  1 
ATOM   1792 C CD1 . TYR A 1 245 ? -41.120 26.107  -34.360 0.50  50.49 ? 245  TYR A CD1 1 
ATOM   1793 C CD2 . TYR A 1 245 ? -40.443 24.211  -35.628 0.50  50.47 ? 245  TYR A CD2 1 
ATOM   1794 C CE1 . TYR A 1 245 ? -41.914 26.528  -35.414 0.50  50.27 ? 245  TYR A CE1 1 
ATOM   1795 C CE2 . TYR A 1 245 ? -41.229 24.621  -36.679 0.50  50.07 ? 245  TYR A CE2 1 
ATOM   1796 C CZ  . TYR A 1 245 ? -41.962 25.778  -36.572 0.50  50.08 ? 245  TYR A CZ  1 
ATOM   1797 O OH  . TYR A 1 245 ? -42.747 26.171  -37.634 0.50  50.17 ? 245  TYR A OH  1 
ATOM   1798 N N   . ALA A 1 246 ? -38.943 22.293  -31.061 1.00  51.23 ? 246  ALA A N   1 
ATOM   1799 C CA  . ALA A 1 246 ? -37.868 21.620  -30.316 1.00  51.37 ? 246  ALA A CA  1 
ATOM   1800 C C   . ALA A 1 246 ? -36.918 20.794  -31.207 1.00  51.68 ? 246  ALA A C   1 
ATOM   1801 O O   . ALA A 1 246 ? -37.312 19.751  -31.730 1.00  52.27 ? 246  ALA A O   1 
ATOM   1802 C CB  . ALA A 1 246 ? -38.467 20.734  -29.256 1.00  51.33 ? 246  ALA A CB  1 
ATOM   1803 N N   . ILE A 1 247 ? -35.669 21.231  -31.362 1.00  51.84 ? 247  ILE A N   1 
ATOM   1804 C CA  . ILE A 1 247 ? -34.700 20.495  -32.196 1.00  52.03 ? 247  ILE A CA  1 
ATOM   1805 C C   . ILE A 1 247 ? -33.654 19.722  -31.386 1.00  52.36 ? 247  ILE A C   1 
ATOM   1806 O O   . ILE A 1 247 ? -32.787 20.312  -30.738 1.00  52.52 ? 247  ILE A O   1 
ATOM   1807 C CB  . ILE A 1 247 ? -33.992 21.404  -33.225 1.00  51.87 ? 247  ILE A CB  1 
ATOM   1808 C CG1 . ILE A 1 247 ? -35.024 22.004  -34.180 1.00  52.02 ? 247  ILE A CG1 1 
ATOM   1809 C CG2 . ILE A 1 247 ? -32.932 20.604  -33.999 1.00  52.00 ? 247  ILE A CG2 1 
ATOM   1810 C CD1 . ILE A 1 247 ? -34.443 22.852  -35.310 1.00  51.82 ? 247  ILE A CD1 1 
ATOM   1811 N N   . LEU A 1 248 ? -33.737 18.399  -31.450 1.00  52.75 ? 248  LEU A N   1 
ATOM   1812 C CA  . LEU A 1 248 ? -32.833 17.520  -30.711 1.00  53.28 ? 248  LEU A CA  1 
ATOM   1813 C C   . LEU A 1 248 ? -32.028 16.655  -31.665 1.00  53.90 ? 248  LEU A C   1 
ATOM   1814 O O   . LEU A 1 248 ? -32.612 15.885  -32.444 1.00  54.26 ? 248  LEU A O   1 
ATOM   1815 C CB  . LEU A 1 248 ? -33.645 16.609  -29.816 1.00  53.02 ? 248  LEU A CB  1 
ATOM   1816 C CG  . LEU A 1 248 ? -34.709 17.349  -29.023 1.00  53.51 ? 248  LEU A CG  1 
ATOM   1817 C CD1 . LEU A 1 248 ? -35.971 16.507  -28.916 1.00  53.15 ? 248  LEU A CD1 1 
ATOM   1818 C CD2 . LEU A 1 248 ? -34.147 17.740  -27.655 1.00  53.94 ? 248  LEU A CD2 1 
ATOM   1819 N N   . THR A 1 249 ? -30.701 16.771  -31.619 1.00  54.21 ? 249  THR A N   1 
ATOM   1820 C CA  . THR A 1 249 ? -29.872 15.951  -32.501 1.00  54.60 ? 249  THR A CA  1 
ATOM   1821 C C   . THR A 1 249 ? -30.150 14.475  -32.218 1.00  54.58 ? 249  THR A C   1 
ATOM   1822 O O   . THR A 1 249 ? -30.544 13.730  -33.119 1.00  54.71 ? 249  THR A O   1 
ATOM   1823 C CB  . THR A 1 249 ? -28.334 16.329  -32.484 1.00  54.80 ? 249  THR A CB  1 
ATOM   1824 O OG1 . THR A 1 249 ? -27.523 15.147  -32.359 1.00  55.65 ? 249  THR A OG1 1 
ATOM   1825 C CG2 . THR A 1 249 ? -27.989 17.303  -31.364 1.00  54.79 ? 249  THR A CG2 1 
ATOM   1826 N N   . HIS A 1 250 ? -30.005 14.080  -30.956 0.10  54.49 ? 250  HIS A N   1 
ATOM   1827 C CA  . HIS A 1 250 ? -30.307 12.719  -30.530 0.10  54.43 ? 250  HIS A CA  1 
ATOM   1828 C C   . HIS A 1 250 ? -31.686 12.626  -29.891 0.10  54.55 ? 250  HIS A C   1 
ATOM   1829 O O   . HIS A 1 250 ? -31.919 13.173  -28.814 0.10  54.48 ? 250  HIS A O   1 
ATOM   1830 C CB  . HIS A 1 250 ? -29.244 12.226  -29.555 0.10  54.38 ? 250  HIS A CB  1 
ATOM   1831 C CG  . HIS A 1 250 ? -27.848 12.375  -30.069 0.10  54.17 ? 250  HIS A CG  1 
ATOM   1832 N ND1 . HIS A 1 250 ? -27.348 11.599  -31.091 0.10  54.12 ? 250  HIS A ND1 1 
ATOM   1833 C CD2 . HIS A 1 250 ? -26.849 13.214  -29.709 0.10  53.99 ? 250  HIS A CD2 1 
ATOM   1834 C CE1 . HIS A 1 250 ? -26.099 11.951  -31.338 0.10  54.05 ? 250  HIS A CE1 1 
ATOM   1835 N NE2 . HIS A 1 250 ? -25.772 12.929  -30.512 0.10  53.90 ? 250  HIS A NE2 1 
ATOM   1836 N N   . GLY A 1 251 ? -32.596 11.930  -30.562 0.10  54.77 ? 251  GLY A N   1 
ATOM   1837 C CA  . GLY A 1 251 ? -33.942 11.739  -30.043 0.10  55.15 ? 251  GLY A CA  1 
ATOM   1838 C C   . GLY A 1 251 ? -34.121 10.370  -29.421 0.10  55.47 ? 251  GLY A C   1 
ATOM   1839 O O   . GLY A 1 251 ? -34.332 9.380   -30.126 0.10  55.45 ? 251  GLY A O   1 
ATOM   1840 N N   . ILE A 1 252 ? -34.035 10.315  -28.097 1.00  55.84 ? 252  ILE A N   1 
ATOM   1841 C CA  . ILE A 1 252 ? -34.171 9.045   -27.376 1.00  56.50 ? 252  ILE A CA  1 
ATOM   1842 C C   . ILE A 1 252 ? -35.620 8.766   -26.939 1.00  56.84 ? 252  ILE A C   1 
ATOM   1843 O O   . ILE A 1 252 ? -36.085 7.622   -27.015 1.00  56.89 ? 252  ILE A O   1 
ATOM   1844 C CB  . ILE A 1 252 ? -33.184 8.920   -26.178 1.00  56.60 ? 252  ILE A CB  1 
ATOM   1845 C CG1 . ILE A 1 252 ? -31.920 9.773   -26.421 1.00  57.32 ? 252  ILE A CG1 1 
ATOM   1846 C CG2 . ILE A 1 252 ? -32.857 7.443   -25.945 1.00  55.99 ? 252  ILE A CG2 1 
ATOM   1847 C CD1 . ILE A 1 252 ? -30.773 9.556   -25.428 1.00  58.70 ? 252  ILE A CD1 1 
ATOM   1848 N N   . PHE A 1 253 ? -36.315 9.807   -26.474 0.20  57.24 ? 253  PHE A N   1 
ATOM   1849 C CA  . PHE A 1 253 ? -37.773 9.774   -26.256 0.20  57.68 ? 253  PHE A CA  1 
ATOM   1850 C C   . PHE A 1 253 ? -38.330 8.569   -25.478 0.20  58.04 ? 253  PHE A C   1 
ATOM   1851 O O   . PHE A 1 253 ? -39.444 8.102   -25.743 0.20  58.22 ? 253  PHE A O   1 
ATOM   1852 C CB  . PHE A 1 253 ? -38.519 9.877   -27.590 0.20  57.78 ? 253  PHE A CB  1 
ATOM   1853 C CG  . PHE A 1 253 ? -38.170 11.085  -28.401 0.20  58.19 ? 253  PHE A CG  1 
ATOM   1854 C CD1 . PHE A 1 253 ? -38.035 10.987  -29.778 0.20  58.32 ? 253  PHE A CD1 1 
ATOM   1855 C CD2 . PHE A 1 253 ? -37.980 12.316  -27.796 0.20  58.55 ? 253  PHE A CD2 1 
ATOM   1856 C CE1 . PHE A 1 253 ? -37.721 12.098  -30.535 0.20  58.71 ? 253  PHE A CE1 1 
ATOM   1857 C CE2 . PHE A 1 253 ? -37.659 13.432  -28.548 0.20  59.10 ? 253  PHE A CE2 1 
ATOM   1858 C CZ  . PHE A 1 253 ? -37.533 13.323  -29.921 0.20  58.76 ? 253  PHE A CZ  1 
ATOM   1859 N N   . SER A 1 254 ? -37.568 8.080   -24.509 1.00  58.42 ? 254  SER A N   1 
ATOM   1860 C CA  . SER A 1 254 ? -38.011 6.960   -23.697 1.00  58.91 ? 254  SER A CA  1 
ATOM   1861 C C   . SER A 1 254 ? -39.093 7.375   -22.705 1.00  59.33 ? 254  SER A C   1 
ATOM   1862 O O   . SER A 1 254 ? -39.268 8.565   -22.416 1.00  59.59 ? 254  SER A O   1 
ATOM   1863 C CB  . SER A 1 254 ? -36.821 6.364   -22.945 1.00  59.06 ? 254  SER A CB  1 
ATOM   1864 O OG  . SER A 1 254 ? -36.114 7.367   -22.226 1.00  59.19 ? 254  SER A OG  1 
ATOM   1865 N N   . GLY A 1 255 ? -39.806 6.379   -22.181 1.00  59.78 ? 255  GLY A N   1 
ATOM   1866 C CA  . GLY A 1 255 ? -40.824 6.590   -21.150 1.00  60.12 ? 255  GLY A CA  1 
ATOM   1867 C C   . GLY A 1 255 ? -42.077 7.327   -21.595 1.00  60.37 ? 255  GLY A C   1 
ATOM   1868 O O   . GLY A 1 255 ? -42.731 6.901   -22.563 1.00  60.23 ? 255  GLY A O   1 
ATOM   1869 N N   . PRO A 1 256 ? -42.411 8.443   -20.900 1.00  60.61 ? 256  PRO A N   1 
ATOM   1870 C CA  . PRO A 1 256 ? -43.632 9.204   -21.194 1.00  60.88 ? 256  PRO A CA  1 
ATOM   1871 C C   . PRO A 1 256 ? -43.404 10.205  -22.333 1.00  61.06 ? 256  PRO A C   1 
ATOM   1872 O O   . PRO A 1 256 ? -44.365 10.835  -22.797 1.00  61.13 ? 256  PRO A O   1 
ATOM   1873 C CB  . PRO A 1 256 ? -43.958 9.931   -19.880 1.00  60.82 ? 256  PRO A CB  1 
ATOM   1874 C CG  . PRO A 1 256 ? -42.663 9.984   -19.143 1.00  60.77 ? 256  PRO A CG  1 
ATOM   1875 C CD  . PRO A 1 256 ? -41.942 8.723   -19.501 1.00  60.65 ? 256  PRO A CD  1 
ATOM   1876 N N   . ALA A 1 257 ? -42.158 10.324  -22.791 1.00  61.29 ? 257  ALA A N   1 
ATOM   1877 C CA  . ALA A 1 257 ? -41.789 11.329  -23.795 1.00  61.61 ? 257  ALA A CA  1 
ATOM   1878 C C   . ALA A 1 257 ? -42.830 11.513  -24.893 1.00  61.68 ? 257  ALA A C   1 
ATOM   1879 O O   . ALA A 1 257 ? -43.419 12.592  -25.026 1.00  61.51 ? 257  ALA A O   1 
ATOM   1880 C CB  . ALA A 1 257 ? -40.428 11.016  -24.395 1.00  61.59 ? 257  ALA A CB  1 
ATOM   1881 N N   . ILE A 1 258 ? -43.072 10.447  -25.652 1.00  61.90 ? 258  ILE A N   1 
ATOM   1882 C CA  . ILE A 1 258 ? -43.940 10.514  -26.839 1.00  62.39 ? 258  ILE A CA  1 
ATOM   1883 C C   . ILE A 1 258 ? -45.323 11.148  -26.573 1.00  62.39 ? 258  ILE A C   1 
ATOM   1884 O O   . ILE A 1 258 ? -45.811 11.957  -27.370 1.00  62.48 ? 258  ILE A O   1 
ATOM   1885 C CB  . ILE A 1 258 ? -44.044 9.119   -27.532 1.00  62.51 ? 258  ILE A CB  1 
ATOM   1886 C CG1 . ILE A 1 258 ? -42.652 8.669   -28.026 1.00  62.89 ? 258  ILE A CG1 1 
ATOM   1887 C CG2 . ILE A 1 258 ? -45.088 9.127   -28.664 1.00  62.67 ? 258  ILE A CG2 1 
ATOM   1888 C CD1 . ILE A 1 258 ? -41.872 9.734   -28.840 1.00  62.64 ? 258  ILE A CD1 1 
ATOM   1889 N N   . SER A 1 259 ? -45.926 10.786  -25.441 1.00  62.56 ? 259  SER A N   1 
ATOM   1890 C CA  . SER A 1 259 ? -47.203 11.361  -25.016 1.00  62.60 ? 259  SER A CA  1 
ATOM   1891 C C   . SER A 1 259 ? -47.048 12.787  -24.460 1.00  62.55 ? 259  SER A C   1 
ATOM   1892 O O   . SER A 1 259 ? -47.965 13.601  -24.566 1.00  62.55 ? 259  SER A O   1 
ATOM   1893 C CB  . SER A 1 259 ? -47.886 10.445  -23.990 1.00  62.69 ? 259  SER A CB  1 
ATOM   1894 O OG  . SER A 1 259 ? -46.980 10.035  -22.968 1.00  62.94 ? 259  SER A OG  1 
ATOM   1895 N N   . ARG A 1 260 ? -45.891 13.078  -23.870 1.00  62.39 ? 260  ARG A N   1 
ATOM   1896 C CA  . ARG A 1 260 ? -45.615 14.409  -23.343 1.00  62.61 ? 260  ARG A CA  1 
ATOM   1897 C C   . ARG A 1 260 ? -45.458 15.425  -24.489 1.00  62.56 ? 260  ARG A C   1 
ATOM   1898 O O   . ARG A 1 260 ? -45.766 16.619  -24.341 1.00  62.35 ? 260  ARG A O   1 
ATOM   1899 C CB  . ARG A 1 260 ? -44.364 14.370  -22.457 1.00  62.92 ? 260  ARG A CB  1 
ATOM   1900 C CG  . ARG A 1 260 ? -44.552 13.689  -21.096 1.00  63.69 ? 260  ARG A CG  1 
ATOM   1901 C CD  . ARG A 1 260 ? -43.237 13.646  -20.341 1.00  65.51 ? 260  ARG A CD  1 
ATOM   1902 N NE  . ARG A 1 260 ? -43.410 13.494  -18.894 1.00  66.91 ? 260  ARG A NE  1 
ATOM   1903 C CZ  . ARG A 1 260 ? -42.409 13.430  -18.015 1.00  67.37 ? 260  ARG A CZ  1 
ATOM   1904 N NH1 . ARG A 1 260 ? -41.145 13.500  -18.424 1.00  68.63 ? 260  ARG A NH1 1 
ATOM   1905 N NH2 . ARG A 1 260 ? -42.671 13.295  -16.723 1.00  67.00 ? 260  ARG A NH2 1 
ATOM   1906 N N   . ILE A 1 261 ? -44.998 14.918  -25.635 1.00  62.51 ? 261  ILE A N   1 
ATOM   1907 C CA  . ILE A 1 261 ? -44.735 15.723  -26.830 1.00  62.33 ? 261  ILE A CA  1 
ATOM   1908 C C   . ILE A 1 261 ? -46.034 16.187  -27.500 1.00  62.39 ? 261  ILE A C   1 
ATOM   1909 O O   . ILE A 1 261 ? -46.274 17.395  -27.621 1.00  62.55 ? 261  ILE A O   1 
ATOM   1910 C CB  . ILE A 1 261 ? -43.806 14.965  -27.820 1.00  62.11 ? 261  ILE A CB  1 
ATOM   1911 C CG1 . ILE A 1 261 ? -42.399 14.852  -27.217 1.00  62.59 ? 261  ILE A CG1 1 
ATOM   1912 C CG2 . ILE A 1 261 ? -43.771 15.664  -29.167 1.00  61.97 ? 261  ILE A CG2 1 
ATOM   1913 C CD1 . ILE A 1 261 ? -41.513 13.767  -27.827 1.00  63.62 ? 261  ILE A CD1 1 
ATOM   1914 N N   . ASN A 1 262 ? -46.864 15.226  -27.921 1.00  62.40 ? 262  ASN A N   1 
ATOM   1915 C CA  . ASN A 1 262 ? -48.182 15.519  -28.488 1.00  62.24 ? 262  ASN A CA  1 
ATOM   1916 C C   . ASN A 1 262 ? -48.910 16.486  -27.567 1.00  61.84 ? 262  ASN A C   1 
ATOM   1917 O O   . ASN A 1 262 ? -49.365 17.548  -28.011 1.00  61.65 ? 262  ASN A O   1 
ATOM   1918 C CB  . ASN A 1 262 ? -49.004 14.235  -28.663 1.00  62.61 ? 262  ASN A CB  1 
ATOM   1919 C CG  . ASN A 1 262 ? -48.259 13.158  -29.439 1.00  63.74 ? 262  ASN A CG  1 
ATOM   1920 O OD1 . ASN A 1 262 ? -47.750 13.403  -30.539 1.00  65.11 ? 262  ASN A OD1 1 
ATOM   1921 N ND2 . ASN A 1 262 ? -48.201 11.951  -28.870 1.00  64.34 ? 262  ASN A ND2 1 
ATOM   1922 N N   . ASN A 1 263 ? -48.958 16.124  -26.276 1.00  61.37 ? 263  ASN A N   1 
ATOM   1923 C CA  . ASN A 1 263 ? -49.578 16.942  -25.221 1.00  60.83 ? 263  ASN A CA  1 
ATOM   1924 C C   . ASN A 1 263 ? -49.053 18.374  -25.115 1.00  60.54 ? 263  ASN A C   1 
ATOM   1925 O O   . ASN A 1 263 ? -49.744 19.249  -24.565 1.00  60.54 ? 263  ASN A O   1 
ATOM   1926 C CB  . ASN A 1 263 ? -49.481 16.258  -23.855 1.00  60.54 ? 263  ASN A CB  1 
ATOM   1927 C CG  . ASN A 1 263 ? -50.802 15.656  -23.408 1.00  60.27 ? 263  ASN A CG  1 
ATOM   1928 O OD1 . ASN A 1 263 ? -51.766 16.377  -23.116 1.00  58.84 ? 263  ASN A OD1 1 
ATOM   1929 N ND2 . ASN A 1 263 ? -50.851 14.325  -23.334 1.00  60.32 ? 263  ASN A ND2 1 
ATOM   1930 N N   . ALA A 1 264 ? -47.842 18.604  -25.634 1.00  59.89 ? 264  ALA A N   1 
ATOM   1931 C CA  . ALA A 1 264 ? -47.249 19.945  -25.637 1.00  59.26 ? 264  ALA A CA  1 
ATOM   1932 C C   . ALA A 1 264 ? -47.501 20.693  -26.945 1.00  58.71 ? 264  ALA A C   1 
ATOM   1933 O O   . ALA A 1 264 ? -47.939 20.115  -27.954 1.00  58.23 ? 264  ALA A O   1 
ATOM   1934 C CB  . ALA A 1 264 ? -45.760 19.893  -25.322 1.00  59.48 ? 264  ALA A CB  1 
ATOM   1935 N N   . CYS A 1 265 ? -47.209 21.988  -26.900 1.00  57.89 ? 265  CYS A N   1 
ATOM   1936 C CA  . CYS A 1 265 ? -47.603 22.924  -27.939 1.00  57.14 ? 265  CYS A CA  1 
ATOM   1937 C C   . CYS A 1 265 ? -46.617 22.958  -29.107 1.00  56.20 ? 265  CYS A C   1 
ATOM   1938 O O   . CYS A 1 265 ? -46.838 23.677  -30.091 1.00  56.09 ? 265  CYS A O   1 
ATOM   1939 C CB  . CYS A 1 265 ? -47.736 24.313  -27.321 1.00  57.27 ? 265  CYS A CB  1 
ATOM   1940 S SG  . CYS A 1 265 ? -46.354 24.688  -26.211 1.00  58.95 ? 265  CYS A SG  1 
ATOM   1941 N N   . PHE A 1 266 ? -45.537 22.182  -28.999 1.00  55.06 ? 266  PHE A N   1 
ATOM   1942 C CA  . PHE A 1 266 ? -44.558 22.074  -30.080 1.00  53.91 ? 266  PHE A CA  1 
ATOM   1943 C C   . PHE A 1 266 ? -45.221 22.122  -31.461 1.00  53.66 ? 266  PHE A C   1 
ATOM   1944 O O   . PHE A 1 266 ? -46.013 21.236  -31.822 1.00  53.70 ? 266  PHE A O   1 
ATOM   1945 C CB  . PHE A 1 266 ? -43.719 20.799  -29.950 1.00  53.41 ? 266  PHE A CB  1 
ATOM   1946 C CG  . PHE A 1 266 ? -42.883 20.742  -28.704 1.00  52.86 ? 266  PHE A CG  1 
ATOM   1947 C CD1 . PHE A 1 266 ? -43.038 19.700  -27.798 1.00  52.07 ? 266  PHE A CD1 1 
ATOM   1948 C CD2 . PHE A 1 266 ? -41.942 21.732  -28.427 1.00  52.45 ? 266  PHE A CD2 1 
ATOM   1949 C CE1 . PHE A 1 266 ? -42.274 19.648  -26.643 1.00  51.29 ? 266  PHE A CE1 1 
ATOM   1950 C CE2 . PHE A 1 266 ? -41.171 21.684  -27.270 1.00  50.62 ? 266  PHE A CE2 1 
ATOM   1951 C CZ  . PHE A 1 266 ? -41.336 20.644  -26.385 1.00  50.99 ? 266  PHE A CZ  1 
ATOM   1952 N N   . GLU A 1 267 ? -44.911 23.173  -32.218 1.00  52.92 ? 267  GLU A N   1 
ATOM   1953 C CA  . GLU A 1 267 ? -45.319 23.240  -33.605 1.00  52.40 ? 267  GLU A CA  1 
ATOM   1954 C C   . GLU A 1 267 ? -44.813 21.993  -34.312 1.00  51.89 ? 267  GLU A C   1 
ATOM   1955 O O   . GLU A 1 267 ? -45.458 21.506  -35.246 1.00  52.34 ? 267  GLU A O   1 
ATOM   1956 C CB  . GLU A 1 267 ? -44.774 24.509  -34.277 1.00  52.71 ? 267  GLU A CB  1 
ATOM   1957 C CG  . GLU A 1 267 ? -45.092 24.627  -35.784 1.00  53.79 ? 267  GLU A CG  1 
ATOM   1958 C CD  . GLU A 1 267 ? -46.585 24.727  -36.086 1.00  55.53 ? 267  GLU A CD  1 
ATOM   1959 O OE1 . GLU A 1 267 ? -47.379 24.904  -35.131 1.00  56.39 ? 267  GLU A OE1 1 
ATOM   1960 O OE2 . GLU A 1 267 ? -46.969 24.637  -37.277 1.00  56.05 ? 267  GLU A OE2 1 
ATOM   1961 N N   . ALA A 1 268 ? -43.667 21.485  -33.838 1.00  51.09 ? 268  ALA A N   1 
ATOM   1962 C CA  . ALA A 1 268 ? -42.962 20.313  -34.384 1.00  50.31 ? 268  ALA A CA  1 
ATOM   1963 C C   . ALA A 1 268 ? -41.744 19.947  -33.509 1.00  49.90 ? 268  ALA A C   1 
ATOM   1964 O O   . ALA A 1 268 ? -41.252 20.766  -32.728 1.00  49.73 ? 268  ALA A O   1 
ATOM   1965 C CB  . ALA A 1 268 ? -42.524 20.561  -35.846 1.00  49.86 ? 268  ALA A CB  1 
ATOM   1966 N N   . VAL A 1 269 ? -41.260 18.714  -33.643 1.00  49.47 ? 269  VAL A N   1 
ATOM   1967 C CA  . VAL A 1 269 ? -40.077 18.273  -32.918 1.00  48.86 ? 269  VAL A CA  1 
ATOM   1968 C C   . VAL A 1 269 ? -39.125 17.538  -33.853 1.00  48.62 ? 269  VAL A C   1 
ATOM   1969 O O   . VAL A 1 269 ? -39.334 16.363  -34.155 1.00  48.64 ? 269  VAL A O   1 
ATOM   1970 C CB  . VAL A 1 269 ? -40.437 17.351  -31.740 1.00  48.87 ? 269  VAL A CB  1 
ATOM   1971 C CG1 . VAL A 1 269 ? -39.216 17.137  -30.847 1.00  48.87 ? 269  VAL A CG1 1 
ATOM   1972 C CG2 . VAL A 1 269 ? -41.579 17.934  -30.934 1.00  48.52 ? 269  VAL A CG2 1 
ATOM   1973 N N   . VAL A 1 270 ? -38.086 18.234  -34.310 1.00  48.18 ? 270  VAL A N   1 
ATOM   1974 C CA  . VAL A 1 270 ? -37.115 17.647  -35.234 1.00  47.93 ? 270  VAL A CA  1 
ATOM   1975 C C   . VAL A 1 270 ? -36.141 16.744  -34.489 1.00  47.86 ? 270  VAL A C   1 
ATOM   1976 O O   . VAL A 1 270 ? -35.786 17.005  -33.335 1.00  48.03 ? 270  VAL A O   1 
ATOM   1977 C CB  . VAL A 1 270 ? -36.299 18.730  -36.005 1.00  47.92 ? 270  VAL A CB  1 
ATOM   1978 C CG1 . VAL A 1 270 ? -35.679 18.137  -37.263 1.00  47.78 ? 270  VAL A CG1 1 
ATOM   1979 C CG2 . VAL A 1 270 ? -37.169 19.915  -36.367 1.00  48.01 ? 270  VAL A CG2 1 
ATOM   1980 N N   . VAL A 1 271 ? -35.720 15.678  -35.155 1.00  47.77 ? 271  VAL A N   1 
ATOM   1981 C CA  . VAL A 1 271 ? -34.615 14.850  -34.685 1.00  47.91 ? 271  VAL A CA  1 
ATOM   1982 C C   . VAL A 1 271 ? -33.732 14.449  -35.860 1.00  48.14 ? 271  VAL A C   1 
ATOM   1983 O O   . VAL A 1 271 ? -34.080 14.698  -37.024 1.00  48.12 ? 271  VAL A O   1 
ATOM   1984 C CB  . VAL A 1 271 ? -35.107 13.584  -33.957 1.00  47.90 ? 271  VAL A CB  1 
ATOM   1985 C CG1 . VAL A 1 271 ? -35.463 13.901  -32.511 1.00  47.61 ? 271  VAL A CG1 1 
ATOM   1986 C CG2 . VAL A 1 271 ? -36.284 12.964  -34.688 1.00  48.19 ? 271  VAL A CG2 1 
ATOM   1987 N N   . THR A 1 272 ? -32.572 13.868  -35.557 1.00  48.45 ? 272  THR A N   1 
ATOM   1988 C CA  . THR A 1 272 ? -31.795 13.188  -36.580 1.00  49.02 ? 272  THR A CA  1 
ATOM   1989 C C   . THR A 1 272 ? -32.219 11.734  -36.468 1.00  49.92 ? 272  THR A C   1 
ATOM   1990 O O   . THR A 1 272 ? -32.969 11.378  -35.542 1.00  49.81 ? 272  THR A O   1 
ATOM   1991 C CB  . THR A 1 272 ? -30.271 13.268  -36.345 1.00  48.94 ? 272  THR A CB  1 
ATOM   1992 O OG1 . THR A 1 272 ? -29.917 12.451  -35.217 1.00  48.40 ? 272  THR A OG1 1 
ATOM   1993 C CG2 . THR A 1 272 ? -29.804 14.716  -36.131 1.00  48.31 ? 272  THR A CG2 1 
ATOM   1994 N N   . ASN A 1 273 ? -31.764 10.895  -37.397 1.00  50.64 ? 273  ASN A N   1 
ATOM   1995 C CA  . ASN A 1 273 ? -31.916 9.454   -37.204 1.00  51.62 ? 273  ASN A CA  1 
ATOM   1996 C C   . ASN A 1 273 ? -30.637 8.781   -36.688 1.00  52.07 ? 273  ASN A C   1 
ATOM   1997 O O   . ASN A 1 273 ? -30.244 7.731   -37.190 1.00  52.12 ? 273  ASN A O   1 
ATOM   1998 C CB  . ASN A 1 273 ? -32.486 8.750   -38.447 1.00  51.62 ? 273  ASN A CB  1 
ATOM   1999 C CG  . ASN A 1 273 ? -31.606 8.910   -39.671 1.00  52.50 ? 273  ASN A CG  1 
ATOM   2000 O OD1 . ASN A 1 273 ? -31.418 7.964   -40.446 1.00  52.90 ? 273  ASN A OD1 1 
ATOM   2001 N ND2 . ASN A 1 273 ? -31.064 10.107  -39.852 1.00  53.61 ? 273  ASN A ND2 1 
ATOM   2002 N N   . THR A 1 274 ? -29.999 9.389   -35.681 1.00  52.87 ? 274  THR A N   1 
ATOM   2003 C CA  . THR A 1 274 ? -28.922 8.710   -34.933 1.00  53.70 ? 274  THR A CA  1 
ATOM   2004 C C   . THR A 1 274 ? -29.518 7.580   -34.078 1.00  54.06 ? 274  THR A C   1 
ATOM   2005 O O   . THR A 1 274 ? -28.824 6.644   -33.685 1.00  54.10 ? 274  THR A O   1 
ATOM   2006 C CB  . THR A 1 274 ? -28.089 9.669   -34.008 1.00  53.80 ? 274  THR A CB  1 
ATOM   2007 O OG1 . THR A 1 274 ? -28.925 10.241  -32.990 1.00  54.09 ? 274  THR A OG1 1 
ATOM   2008 C CG2 . THR A 1 274 ? -27.397 10.767  -34.811 1.00  53.78 ? 274  THR A CG2 1 
ATOM   2009 N N   . ILE A 1 275 ? -30.806 7.703   -33.774 1.00  54.68 ? 275  ILE A N   1 
ATOM   2010 C CA  . ILE A 1 275 ? -31.571 6.644   -33.122 1.00  55.33 ? 275  ILE A CA  1 
ATOM   2011 C C   . ILE A 1 275 ? -32.764 6.338   -34.025 1.00  55.49 ? 275  ILE A C   1 
ATOM   2012 O O   . ILE A 1 275 ? -33.289 7.256   -34.661 1.00  55.63 ? 275  ILE A O   1 
ATOM   2013 C CB  . ILE A 1 275 ? -32.052 7.061   -31.699 1.00  55.54 ? 275  ILE A CB  1 
ATOM   2014 C CG1 . ILE A 1 275 ? -30.854 7.253   -30.757 1.00  55.73 ? 275  ILE A CG1 1 
ATOM   2015 C CG2 . ILE A 1 275 ? -33.015 6.012   -31.108 1.00  55.96 ? 275  ILE A CG2 1 
ATOM   2016 C CD1 . ILE A 1 275 ? -31.232 7.661   -29.344 1.00  55.66 ? 275  ILE A CD1 1 
ATOM   2017 N N   . PRO A 1 276 ? -33.175 5.050   -34.118 1.00  55.70 ? 276  PRO A N   1 
ATOM   2018 C CA  . PRO A 1 276 ? -34.385 4.692   -34.883 1.00  55.83 ? 276  PRO A CA  1 
ATOM   2019 C C   . PRO A 1 276 ? -35.615 5.470   -34.395 1.00  56.08 ? 276  PRO A C   1 
ATOM   2020 O O   . PRO A 1 276 ? -35.900 5.500   -33.181 1.00  56.32 ? 276  PRO A O   1 
ATOM   2021 C CB  . PRO A 1 276 ? -34.566 3.198   -34.597 1.00  55.74 ? 276  PRO A CB  1 
ATOM   2022 C CG  . PRO A 1 276 ? -33.218 2.704   -34.221 1.00  55.73 ? 276  PRO A CG  1 
ATOM   2023 C CD  . PRO A 1 276 ? -32.448 3.857   -33.636 1.00  55.81 ? 276  PRO A CD  1 
ATOM   2024 N N   . GLN A 1 277 ? -36.322 6.101   -35.331 0.010 55.80 ? 277  GLN A N   1 
ATOM   2025 C CA  . GLN A 1 277 ? -37.446 6.973   -34.995 0.010 55.62 ? 277  GLN A CA  1 
ATOM   2026 C C   . GLN A 1 277 ? -38.754 6.505   -35.631 0.010 55.53 ? 277  GLN A C   1 
ATOM   2027 O O   . GLN A 1 277 ? -39.827 6.995   -35.284 0.010 55.51 ? 277  GLN A O   1 
ATOM   2028 C CB  . GLN A 1 277 ? -37.149 8.416   -35.421 0.010 55.60 ? 277  GLN A CB  1 
ATOM   2029 C CG  . GLN A 1 277 ? -35.797 8.952   -34.962 0.010 55.54 ? 277  GLN A CG  1 
ATOM   2030 C CD  . GLN A 1 277 ? -35.719 9.157   -33.460 0.010 55.50 ? 277  GLN A CD  1 
ATOM   2031 O OE1 . GLN A 1 277 ? -34.864 8.586   -32.784 0.010 55.48 ? 277  GLN A OE1 1 
ATOM   2032 N NE2 . GLN A 1 277 ? -36.620 9.975   -32.929 0.010 55.49 ? 277  GLN A NE2 1 
ATOM   2033 N N   . GLU A 1 278 ? -38.660 5.544   -36.547 0.010 55.46 ? 278  GLU A N   1 
ATOM   2034 C CA  . GLU A 1 278 ? -39.819 5.087   -37.313 0.010 55.42 ? 278  GLU A CA  1 
ATOM   2035 C C   . GLU A 1 278 ? -40.998 4.644   -36.442 0.010 55.46 ? 278  GLU A C   1 
ATOM   2036 O O   . GLU A 1 278 ? -42.157 4.802   -36.827 0.010 55.45 ? 278  GLU A O   1 
ATOM   2037 C CB  . GLU A 1 278 ? -39.414 3.964   -38.273 0.010 55.40 ? 278  GLU A CB  1 
ATOM   2038 C CG  . GLU A 1 278 ? -38.276 4.337   -39.213 0.010 55.33 ? 278  GLU A CG  1 
ATOM   2039 C CD  . GLU A 1 278 ? -36.937 4.430   -38.504 0.010 55.26 ? 278  GLU A CD  1 
ATOM   2040 O OE1 . GLU A 1 278 ? -36.463 5.565   -38.273 0.010 55.25 ? 278  GLU A OE1 1 
ATOM   2041 O OE2 . GLU A 1 278 ? -36.363 3.367   -38.171 0.010 55.23 ? 278  GLU A OE2 1 
ATOM   2042 N N   . ASP A 1 279 ? -40.695 4.091   -35.272 0.010 55.55 ? 279  ASP A N   1 
ATOM   2043 C CA  . ASP A 1 279 ? -41.725 3.587   -34.364 0.010 55.67 ? 279  ASP A CA  1 
ATOM   2044 C C   . ASP A 1 279 ? -42.432 4.712   -33.609 0.010 55.82 ? 279  ASP A C   1 
ATOM   2045 O O   . ASP A 1 279 ? -43.642 4.659   -33.388 0.010 55.82 ? 279  ASP A O   1 
ATOM   2046 C CB  . ASP A 1 279 ? -41.118 2.588   -33.374 0.010 55.63 ? 279  ASP A CB  1 
ATOM   2047 C CG  . ASP A 1 279 ? -42.159 1.949   -32.473 0.010 55.59 ? 279  ASP A CG  1 
ATOM   2048 O OD1 . ASP A 1 279 ? -43.346 2.321   -32.576 0.010 55.55 ? 279  ASP A OD1 1 
ATOM   2049 O OD2 . ASP A 1 279 ? -41.788 1.073   -31.663 0.010 55.54 ? 279  ASP A OD2 1 
ATOM   2050 N N   . LYS A 1 280 ? -41.670 5.729   -33.219 0.010 56.08 ? 280  LYS A N   1 
ATOM   2051 C CA  . LYS A 1 280 ? -42.205 6.844   -32.439 0.010 56.36 ? 280  LYS A CA  1 
ATOM   2052 C C   . LYS A 1 280 ? -42.940 7.876   -33.297 0.010 56.69 ? 280  LYS A C   1 
ATOM   2053 O O   . LYS A 1 280 ? -43.734 8.668   -32.783 0.010 56.68 ? 280  LYS A O   1 
ATOM   2054 C CB  . LYS A 1 280 ? -41.083 7.514   -31.647 0.010 56.31 ? 280  LYS A CB  1 
ATOM   2055 C CG  . LYS A 1 280 ? -40.450 6.606   -30.606 0.010 56.22 ? 280  LYS A CG  1 
ATOM   2056 C CD  . LYS A 1 280 ? -39.188 7.217   -30.027 0.010 56.07 ? 280  LYS A CD  1 
ATOM   2057 C CE  . LYS A 1 280 ? -38.562 6.302   -28.986 0.010 56.01 ? 280  LYS A CE  1 
ATOM   2058 N NZ  . LYS A 1 280 ? -39.490 6.030   -27.854 0.010 55.96 ? 280  LYS A NZ  1 
ATOM   2059 N N   . MET A 1 281 ? -42.662 7.855   -34.599 1.00  57.10 ? 281  MET A N   1 
ATOM   2060 C CA  . MET A 1 281 ? -43.307 8.738   -35.582 1.00  57.87 ? 281  MET A CA  1 
ATOM   2061 C C   . MET A 1 281 ? -44.794 8.401   -35.722 1.00  57.57 ? 281  MET A C   1 
ATOM   2062 O O   . MET A 1 281 ? -45.655 9.292   -35.788 1.00  57.74 ? 281  MET A O   1 
ATOM   2063 C CB  . MET A 1 281 ? -42.621 8.639   -36.964 1.00  58.17 ? 281  MET A CB  1 
ATOM   2064 C CG  . MET A 1 281 ? -41.148 9.100   -37.010 1.00  59.64 ? 281  MET A CG  1 
ATOM   2065 S SD  . MET A 1 281 ? -40.531 9.558   -38.672 1.00  64.00 ? 281  MET A SD  1 
ATOM   2066 C CE  . MET A 1 281 ? -40.669 8.018   -39.594 1.00  62.22 ? 281  MET A CE  1 
ATOM   2067 N N   . LYS A 1 282 ? -45.080 7.102   -35.770 0.010 56.94 ? 282  LYS A N   1 
ATOM   2068 C CA  . LYS A 1 282 ? -46.445 6.600   -35.860 0.010 56.36 ? 282  LYS A CA  1 
ATOM   2069 C C   . LYS A 1 282 ? -47.268 7.087   -34.676 0.010 56.01 ? 282  LYS A C   1 
ATOM   2070 O O   . LYS A 1 282 ? -48.478 7.281   -34.784 0.010 55.95 ? 282  LYS A O   1 
ATOM   2071 C CB  . LYS A 1 282 ? -46.442 5.073   -35.879 0.010 56.36 ? 282  LYS A CB  1 
ATOM   2072 C CG  . LYS A 1 282 ? -45.461 4.461   -36.861 0.010 56.27 ? 282  LYS A CG  1 
ATOM   2073 C CD  . LYS A 1 282 ? -45.376 2.953   -36.665 0.010 56.19 ? 282  LYS A CD  1 
ATOM   2074 C CE  . LYS A 1 282 ? -44.614 2.299   -37.818 0.010 56.14 ? 282  LYS A CE  1 
ATOM   2075 N NZ  . LYS A 1 282 ? -44.648 0.785   -37.750 0.010 56.12 ? 282  LYS A NZ  1 
ATOM   2076 N N   . HIS A 1 283 ? -46.597 7.287   -33.546 0.010 55.60 ? 283  HIS A N   1 
ATOM   2077 C CA  . HIS A 1 283 ? -47.267 7.696   -32.323 0.010 55.24 ? 283  HIS A CA  1 
ATOM   2078 C C   . HIS A 1 283 ? -47.097 9.195   -32.074 0.010 55.10 ? 283  HIS A C   1 
ATOM   2079 O O   . HIS A 1 283 ? -47.498 9.705   -31.028 0.010 55.06 ? 283  HIS A O   1 
ATOM   2080 C CB  . HIS A 1 283 ? -46.723 6.896   -31.137 0.010 55.20 ? 283  HIS A CB  1 
ATOM   2081 C CG  . HIS A 1 283 ? -47.780 6.185   -30.351 0.010 55.04 ? 283  HIS A CG  1 
ATOM   2082 N ND1 . HIS A 1 283 ? -48.623 6.834   -29.475 0.010 54.93 ? 283  HIS A ND1 1 
ATOM   2083 C CD2 . HIS A 1 283 ? -48.130 4.877   -30.311 0.010 54.94 ? 283  HIS A CD2 1 
ATOM   2084 C CE1 . HIS A 1 283 ? -49.448 5.957   -28.930 0.010 54.89 ? 283  HIS A CE1 1 
ATOM   2085 N NE2 . HIS A 1 283 ? -49.170 4.763   -29.420 0.010 54.90 ? 283  HIS A NE2 1 
ATOM   2086 N N   . CYS A 1 284 ? -46.508 9.899   -33.038 0.010 54.97 ? 284  CYS A N   1 
ATOM   2087 C CA  . CYS A 1 284 ? -46.266 11.335  -32.894 0.010 54.91 ? 284  CYS A CA  1 
ATOM   2088 C C   . CYS A 1 284 ? -46.079 12.035  -34.242 0.010 54.93 ? 284  CYS A C   1 
ATOM   2089 O O   . CYS A 1 284 ? -45.050 11.868  -34.900 0.010 54.91 ? 284  CYS A O   1 
ATOM   2090 C CB  . CYS A 1 284 ? -45.051 11.577  -31.999 0.010 54.88 ? 284  CYS A CB  1 
ATOM   2091 S SG  . CYS A 1 284 ? -44.799 13.300  -31.549 0.010 54.85 ? 284  CYS A SG  1 
ATOM   2092 N N   . SER A 1 285 ? -47.070 12.837  -34.629 1.00  55.06 ? 285  SER A N   1 
ATOM   2093 C CA  . SER A 1 285 ? -47.134 13.418  -35.985 1.00  55.21 ? 285  SER A CA  1 
ATOM   2094 C C   . SER A 1 285 ? -46.285 14.680  -36.200 1.00  54.95 ? 285  SER A C   1 
ATOM   2095 O O   . SER A 1 285 ? -45.938 15.020  -37.336 1.00  55.00 ? 285  SER A O   1 
ATOM   2096 C CB  . SER A 1 285 ? -48.586 13.710  -36.373 1.00  55.43 ? 285  SER A CB  1 
ATOM   2097 O OG  . SER A 1 285 ? -48.667 14.052  -37.749 1.00  56.36 ? 285  SER A OG  1 
ATOM   2098 N N   . LYS A 1 286 ? -45.967 15.370  -35.106 1.00  54.65 ? 286  LYS A N   1 
ATOM   2099 C CA  . LYS A 1 286 ? -45.137 16.578  -35.140 1.00  53.68 ? 286  LYS A CA  1 
ATOM   2100 C C   . LYS A 1 286 ? -43.649 16.249  -35.293 1.00  52.97 ? 286  LYS A C   1 
ATOM   2101 O O   . LYS A 1 286 ? -42.844 17.151  -35.551 1.00  52.96 ? 286  LYS A O   1 
ATOM   2102 C CB  . LYS A 1 286 ? -45.396 17.437  -33.894 1.00  53.65 ? 286  LYS A CB  1 
ATOM   2103 C CG  . LYS A 1 286 ? -45.679 16.613  -32.637 1.00  54.05 ? 286  LYS A CG  1 
ATOM   2104 C CD  . LYS A 1 286 ? -46.117 17.460  -31.436 1.00  55.97 ? 286  LYS A CD  1 
ATOM   2105 C CE  . LYS A 1 286 ? -47.631 17.783  -31.437 1.00  56.45 ? 286  LYS A CE  1 
ATOM   2106 N NZ  . LYS A 1 286 ? -47.987 19.098  -32.071 1.00  55.26 ? 286  LYS A NZ  1 
ATOM   2107 N N   . ILE A 1 287 ? -43.291 14.968  -35.152 1.00  52.13 ? 287  ILE A N   1 
ATOM   2108 C CA  . ILE A 1 287 ? -41.900 14.533  -35.344 1.00  51.75 ? 287  ILE A CA  1 
ATOM   2109 C C   . ILE A 1 287 ? -41.477 14.527  -36.824 1.00  51.52 ? 287  ILE A C   1 
ATOM   2110 O O   . ILE A 1 287 ? -42.241 14.146  -37.722 1.00  51.39 ? 287  ILE A O   1 
ATOM   2111 C CB  . ILE A 1 287 ? -41.588 13.150  -34.685 1.00  51.75 ? 287  ILE A CB  1 
ATOM   2112 C CG1 . ILE A 1 287 ? -41.782 13.209  -33.164 1.00  51.86 ? 287  ILE A CG1 1 
ATOM   2113 C CG2 . ILE A 1 287 ? -40.153 12.720  -34.981 1.00  51.84 ? 287  ILE A CG2 1 
ATOM   2114 C CD1 . ILE A 1 287 ? -41.369 11.934  -32.407 1.00  51.03 ? 287  ILE A CD1 1 
ATOM   2115 N N   . GLN A 1 288 ? -40.254 14.972  -37.062 1.00  51.17 ? 288  GLN A N   1 
ATOM   2116 C CA  . GLN A 1 288 ? -39.668 14.938  -38.385 1.00  51.39 ? 288  GLN A CA  1 
ATOM   2117 C C   . GLN A 1 288 ? -38.220 14.497  -38.223 1.00  51.41 ? 288  GLN A C   1 
ATOM   2118 O O   . GLN A 1 288 ? -37.600 14.791  -37.201 1.00  52.07 ? 288  GLN A O   1 
ATOM   2119 C CB  . GLN A 1 288 ? -39.725 16.327  -39.023 1.00  51.45 ? 288  GLN A CB  1 
ATOM   2120 C CG  . GLN A 1 288 ? -41.130 16.906  -39.190 1.00  51.19 ? 288  GLN A CG  1 
ATOM   2121 C CD  . GLN A 1 288 ? -41.137 18.122  -40.091 1.00  51.70 ? 288  GLN A CD  1 
ATOM   2122 O OE1 . GLN A 1 288 ? -40.595 18.099  -41.202 1.00  51.79 ? 288  GLN A OE1 1 
ATOM   2123 N NE2 . GLN A 1 288 ? -41.746 19.198  -39.615 1.00  51.68 ? 288  GLN A NE2 1 
ATOM   2124 N N   . VAL A 1 289 ? -37.673 13.785  -39.203 1.00  50.98 ? 289  VAL A N   1 
ATOM   2125 C CA  . VAL A 1 289 ? -36.277 13.352  -39.089 1.00  50.75 ? 289  VAL A CA  1 
ATOM   2126 C C   . VAL A 1 289 ? -35.375 14.008  -40.130 1.00  50.44 ? 289  VAL A C   1 
ATOM   2127 O O   . VAL A 1 289 ? -35.789 14.269  -41.280 1.00  50.59 ? 289  VAL A O   1 
ATOM   2128 C CB  . VAL A 1 289 ? -36.087 11.785  -39.133 1.00  50.96 ? 289  VAL A CB  1 
ATOM   2129 C CG1 . VAL A 1 289 ? -37.021 11.073  -38.114 1.00  51.03 ? 289  VAL A CG1 1 
ATOM   2130 C CG2 . VAL A 1 289 ? -36.302 11.228  -40.575 1.00  51.09 ? 289  VAL A CG2 1 
ATOM   2131 N N   . ILE A 1 290 ? -34.141 14.273  -39.714 1.00  49.60 ? 290  ILE A N   1 
ATOM   2132 C CA  . ILE A 1 290 ? -33.092 14.626  -40.649 1.00  48.76 ? 290  ILE A CA  1 
ATOM   2133 C C   . ILE A 1 290 ? -32.211 13.393  -40.795 1.00  48.38 ? 290  ILE A C   1 
ATOM   2134 O O   . ILE A 1 290 ? -31.727 12.838  -39.798 1.00  48.31 ? 290  ILE A O   1 
ATOM   2135 C CB  . ILE A 1 290 ? -32.258 15.816  -40.177 1.00  48.53 ? 290  ILE A CB  1 
ATOM   2136 C CG1 . ILE A 1 290 ? -33.164 17.004  -39.838 1.00  48.90 ? 290  ILE A CG1 1 
ATOM   2137 C CG2 . ILE A 1 290 ? -31.267 16.198  -41.252 1.00  49.08 ? 290  ILE A CG2 1 
ATOM   2138 C CD1 . ILE A 1 290 ? -32.448 18.191  -39.172 1.00  49.00 ? 290  ILE A CD1 1 
ATOM   2139 N N   . ASP A 1 291 ? -32.039 12.959  -42.044 1.00  47.62 ? 291  ASP A N   1 
ATOM   2140 C CA  . ASP A 1 291 ? -31.197 11.823  -42.388 1.00  46.61 ? 291  ASP A CA  1 
ATOM   2141 C C   . ASP A 1 291 ? -29.728 12.193  -42.222 1.00  45.67 ? 291  ASP A C   1 
ATOM   2142 O O   . ASP A 1 291 ? -29.256 13.165  -42.809 1.00  45.79 ? 291  ASP A O   1 
ATOM   2143 C CB  . ASP A 1 291 ? -31.476 11.404  -43.833 1.00  46.99 ? 291  ASP A CB  1 
ATOM   2144 C CG  . ASP A 1 291 ? -30.897 10.039  -44.181 1.00  48.23 ? 291  ASP A CG  1 
ATOM   2145 O OD1 . ASP A 1 291 ? -30.407 9.314   -43.278 1.00  50.13 ? 291  ASP A OD1 1 
ATOM   2146 O OD2 . ASP A 1 291 ? -30.947 9.682   -45.377 1.00  48.95 ? 291  ASP A OD2 1 
ATOM   2147 N N   . ILE A 1 292 ? -29.002 11.420  -41.421 1.00  44.63 ? 292  ILE A N   1 
ATOM   2148 C CA  . ILE A 1 292 ? -27.575 11.693  -41.193 1.00  43.83 ? 292  ILE A CA  1 
ATOM   2149 C C   . ILE A 1 292 ? -26.631 10.650  -41.821 1.00  43.07 ? 292  ILE A C   1 
ATOM   2150 O O   . ILE A 1 292 ? -25.399 10.702  -41.642 1.00  42.82 ? 292  ILE A O   1 
ATOM   2151 C CB  . ILE A 1 292 ? -27.249 11.949  -39.696 1.00  43.61 ? 292  ILE A CB  1 
ATOM   2152 C CG1 . ILE A 1 292 ? -27.932 10.936  -38.788 1.00  43.24 ? 292  ILE A CG1 1 
ATOM   2153 C CG2 . ILE A 1 292 ? -27.717 13.317  -39.290 1.00  44.54 ? 292  ILE A CG2 1 
ATOM   2154 C CD1 . ILE A 1 292 ? -27.111 9.718   -38.488 1.00  43.75 ? 292  ILE A CD1 1 
ATOM   2155 N N   . SER A 1 293 ? -27.225 9.732   -42.581 1.00  41.93 ? 293  SER A N   1 
ATOM   2156 C CA  . SER A 1 293 ? -26.503 8.641   -43.229 1.00  40.84 ? 293  SER A CA  1 
ATOM   2157 C C   . SER A 1 293 ? -25.495 9.080   -44.308 1.00  40.30 ? 293  SER A C   1 
ATOM   2158 O O   . SER A 1 293 ? -24.459 8.434   -44.484 1.00  40.02 ? 293  SER A O   1 
ATOM   2159 C CB  . SER A 1 293 ? -27.498 7.624   -43.805 1.00  40.97 ? 293  SER A CB  1 
ATOM   2160 O OG  . SER A 1 293 ? -28.311 8.199   -44.821 1.00  40.27 ? 293  SER A OG  1 
ATOM   2161 N N   . MET A 1 294 ? -25.799 10.142  -45.053 0.73  39.69 ? 294  MET A N   1 
ATOM   2162 C CA  . MET A 1 294 ? -24.827 10.656  -46.022 0.73  39.20 ? 294  MET A CA  1 
ATOM   2163 C C   . MET A 1 294 ? -23.648 11.313  -45.294 0.73  38.69 ? 294  MET A C   1 
ATOM   2164 O O   . MET A 1 294 ? -22.524 11.308  -45.794 0.73  38.71 ? 294  MET A O   1 
ATOM   2165 C CB  . MET A 1 294 ? -25.481 11.593  -47.064 0.73  39.31 ? 294  MET A CB  1 
ATOM   2166 C CG  . MET A 1 294 ? -24.509 12.193  -48.140 0.73  40.20 ? 294  MET A CG  1 
ATOM   2167 S SD  . MET A 1 294 ? -23.495 11.037  -49.150 0.73  40.53 ? 294  MET A SD  1 
ATOM   2168 C CE  . MET A 1 294 ? -24.461 10.943  -50.662 0.73  40.84 ? 294  MET A CE  1 
ATOM   2169 N N   . ILE A 1 295 ? -23.902 11.851  -44.103 1.00  38.17 ? 295  ILE A N   1 
ATOM   2170 C CA  . ILE A 1 295 ? -22.835 12.436  -43.299 1.00  37.69 ? 295  ILE A CA  1 
ATOM   2171 C C   . ILE A 1 295 ? -21.946 11.354  -42.713 1.00  37.45 ? 295  ILE A C   1 
ATOM   2172 O O   . ILE A 1 295 ? -20.726 11.502  -42.702 1.00  38.22 ? 295  ILE A O   1 
ATOM   2173 C CB  . ILE A 1 295 ? -23.359 13.326  -42.173 1.00  37.73 ? 295  ILE A CB  1 
ATOM   2174 C CG1 . ILE A 1 295 ? -24.133 14.525  -42.736 1.00  37.97 ? 295  ILE A CG1 1 
ATOM   2175 C CG2 . ILE A 1 295 ? -22.214 13.811  -41.311 1.00  37.79 ? 295  ILE A CG2 1 
ATOM   2176 C CD1 . ILE A 1 295 ? -25.309 14.973  -41.852 1.00  38.73 ? 295  ILE A CD1 1 
ATOM   2177 N N   . LEU A 1 296 ? -22.538 10.266  -42.235 1.00  36.79 ? 296  LEU A N   1 
ATOM   2178 C CA  . LEU A 1 296 ? -21.739 9.163   -41.699 1.00  36.27 ? 296  LEU A CA  1 
ATOM   2179 C C   . LEU A 1 296 ? -21.063 8.339   -42.799 1.00  35.87 ? 296  LEU A C   1 
ATOM   2180 O O   . LEU A 1 296 ? -19.978 7.798   -42.608 1.00  35.53 ? 296  LEU A O   1 
ATOM   2181 C CB  . LEU A 1 296 ? -22.582 8.270   -40.785 1.00  36.31 ? 296  LEU A CB  1 
ATOM   2182 C CG  . LEU A 1 296 ? -23.132 8.921   -39.507 1.00  36.23 ? 296  LEU A CG  1 
ATOM   2183 C CD1 . LEU A 1 296 ? -24.075 7.961   -38.790 1.00  36.09 ? 296  LEU A CD1 1 
ATOM   2184 C CD2 . LEU A 1 296 ? -22.019 9.360   -38.576 1.00  35.70 ? 296  LEU A CD2 1 
ATOM   2185 N N   . ALA A 1 297 ? -21.699 8.270   -43.957 1.00  36.02 ? 297  ALA A N   1 
ATOM   2186 C CA  . ALA A 1 297 ? -21.186 7.490   -45.085 1.00  36.54 ? 297  ALA A CA  1 
ATOM   2187 C C   . ALA A 1 297 ? -19.973 8.165   -45.682 1.00  36.75 ? 297  ALA A C   1 
ATOM   2188 O O   . ALA A 1 297 ? -19.022 7.510   -46.107 1.00  36.46 ? 297  ALA A O   1 
ATOM   2189 C CB  . ALA A 1 297 ? -22.261 7.319   -46.152 1.00  36.41 ? 297  ALA A CB  1 
ATOM   2190 N N   . GLU A 1 298 ? -20.025 9.490   -45.702 0.99  37.29 ? 298  GLU A N   1 
ATOM   2191 C CA  . GLU A 1 298 ? -18.984 10.293  -46.294 0.99  37.78 ? 298  GLU A CA  1 
ATOM   2192 C C   . GLU A 1 298 ? -17.782 10.341  -45.370 0.99  37.33 ? 298  GLU A C   1 
ATOM   2193 O O   . GLU A 1 298 ? -16.640 10.345  -45.839 0.99  37.39 ? 298  GLU A O   1 
ATOM   2194 C CB  . GLU A 1 298 ? -19.515 11.703  -46.571 0.99  38.33 ? 298  GLU A CB  1 
ATOM   2195 C CG  . GLU A 1 298 ? -18.608 12.561  -47.435 0.99  40.61 ? 298  GLU A CG  1 
ATOM   2196 C CD  . GLU A 1 298 ? -18.632 12.143  -48.876 0.99  43.81 ? 298  GLU A CD  1 
ATOM   2197 O OE1 . GLU A 1 298 ? -19.470 11.282  -49.223 0.99  45.07 ? 298  GLU A OE1 1 
ATOM   2198 O OE2 . GLU A 1 298 ? -17.810 12.671  -49.665 0.99  46.75 ? 298  GLU A OE2 1 
ATOM   2199 N N   . ALA A 1 299 ? -18.054 10.393  -44.065 1.00  36.89 ? 299  ALA A N   1 
ATOM   2200 C CA  . ALA A 1 299 ? -17.008 10.346  -43.048 1.00  36.40 ? 299  ALA A CA  1 
ATOM   2201 C C   . ALA A 1 299 ? -16.303 8.988   -43.055 1.00  36.01 ? 299  ALA A C   1 
ATOM   2202 O O   . ALA A 1 299 ? -15.112 8.915   -42.785 1.00  36.13 ? 299  ALA A O   1 
ATOM   2203 C CB  . ALA A 1 299 ? -17.577 10.663  -41.678 1.00  36.19 ? 299  ALA A CB  1 
ATOM   2204 N N   . ILE A 1 300 ? -17.038 7.929   -43.382 1.00  35.72 ? 300  ILE A N   1 
ATOM   2205 C CA  . ILE A 1 300 ? -16.439 6.605   -43.561 1.00  35.76 ? 300  ILE A CA  1 
ATOM   2206 C C   . ILE A 1 300 ? -15.570 6.534   -44.830 1.00  36.33 ? 300  ILE A C   1 
ATOM   2207 O O   . ILE A 1 300 ? -14.434 6.072   -44.777 1.00  36.46 ? 300  ILE A O   1 
ATOM   2208 C CB  . ILE A 1 300 ? -17.508 5.482   -43.498 1.00  35.32 ? 300  ILE A CB  1 
ATOM   2209 C CG1 . ILE A 1 300 ? -17.993 5.351   -42.045 1.00  35.51 ? 300  ILE A CG1 1 
ATOM   2210 C CG2 . ILE A 1 300 ? -16.947 4.179   -43.972 1.00  33.58 ? 300  ILE A CG2 1 
ATOM   2211 C CD1 . ILE A 1 300 ? -19.297 4.595   -41.826 1.00  34.72 ? 300  ILE A CD1 1 
ATOM   2212 N N   . ARG A 1 301 ? -16.096 7.012   -45.954 0.98  37.00 ? 301  ARG A N   1 
ATOM   2213 C CA  . ARG A 1 301 ? -15.355 7.012   -47.211 0.98  37.86 ? 301  ARG A CA  1 
ATOM   2214 C C   . ARG A 1 301 ? -14.088 7.854   -47.133 0.98  38.35 ? 301  ARG A C   1 
ATOM   2215 O O   . ARG A 1 301 ? -13.073 7.500   -47.734 0.98  39.14 ? 301  ARG A O   1 
ATOM   2216 C CB  . ARG A 1 301 ? -16.219 7.542   -48.346 0.98  38.21 ? 301  ARG A CB  1 
ATOM   2217 C CG  . ARG A 1 301 ? -15.717 7.118   -49.717 0.98  40.59 ? 301  ARG A CG  1 
ATOM   2218 C CD  . ARG A 1 301 ? -16.660 7.525   -50.850 0.98  42.93 ? 301  ARG A CD  1 
ATOM   2219 N NE  . ARG A 1 301 ? -16.101 8.616   -51.652 0.98  44.41 ? 301  ARG A NE  1 
ATOM   2220 C CZ  . ARG A 1 301 ? -16.339 9.909   -51.434 0.98  44.80 ? 301  ARG A CZ  1 
ATOM   2221 N NH1 . ARG A 1 301 ? -17.125 10.283  -50.433 0.98  43.88 ? 301  ARG A NH1 1 
ATOM   2222 N NH2 . ARG A 1 301 ? -15.790 10.824  -52.220 0.98  45.88 ? 301  ARG A NH2 1 
ATOM   2223 N N   . ARG A 1 302 ? -14.147 8.965   -46.400 0.50  38.30 ? 302  ARG A N   1 
ATOM   2224 C CA  . ARG A 1 302 ? -13.004 9.862   -46.269 0.50  38.27 ? 302  ARG A CA  1 
ATOM   2225 C C   . ARG A 1 302 ? -11.993 9.393   -45.232 0.50  38.44 ? 302  ARG A C   1 
ATOM   2226 O O   . ARG A 1 302 ? -10.798 9.641   -45.374 0.50  38.22 ? 302  ARG A O   1 
ATOM   2227 C CB  . ARG A 1 302 ? -13.486 11.274  -45.964 0.50  38.32 ? 302  ARG A CB  1 
ATOM   2228 C CG  . ARG A 1 302 ? -14.223 11.885  -47.144 0.50  38.65 ? 302  ARG A CG  1 
ATOM   2229 C CD  . ARG A 1 302 ? -15.030 13.095  -46.764 0.50  38.23 ? 302  ARG A CD  1 
ATOM   2230 N NE  . ARG A 1 302 ? -15.438 13.830  -47.953 0.50  38.28 ? 302  ARG A NE  1 
ATOM   2231 C CZ  . ARG A 1 302 ? -14.791 14.884  -48.443 0.50  38.25 ? 302  ARG A CZ  1 
ATOM   2232 N NH1 . ARG A 1 302 ? -13.697 15.339  -47.842 0.50  36.52 ? 302  ARG A NH1 1 
ATOM   2233 N NH2 . ARG A 1 302 ? -15.247 15.488  -49.535 0.50  39.45 ? 302  ARG A NH2 1 
ATOM   2234 N N   . THR A 1 303 ? -12.484 8.712   -44.198 1.00  38.92 ? 303  THR A N   1 
ATOM   2235 C CA  . THR A 1 303 ? -11.634 8.136   -43.158 1.00  39.20 ? 303  THR A CA  1 
ATOM   2236 C C   . THR A 1 303 ? -10.834 7.020   -43.773 1.00  39.45 ? 303  THR A C   1 
ATOM   2237 O O   . THR A 1 303 ? -9.675  6.803   -43.390 1.00  39.79 ? 303  THR A O   1 
ATOM   2238 C CB  . THR A 1 303 ? -12.455 7.562   -41.975 1.00  39.24 ? 303  THR A CB  1 
ATOM   2239 O OG1 . THR A 1 303 ? -13.008 8.637   -41.204 1.00  39.10 ? 303  THR A OG1 1 
ATOM   2240 C CG2 . THR A 1 303 ? -11.587 6.714   -41.063 1.00  38.99 ? 303  THR A CG2 1 
ATOM   2241 N N   . HIS A 1 304 ? -11.462 6.321   -44.723 1.00  39.61 ? 304  HIS A N   1 
ATOM   2242 C CA  . HIS A 1 304 ? -10.820 5.233   -45.453 1.00  39.67 ? 304  HIS A CA  1 
ATOM   2243 C C   . HIS A 1 304 ? -9.732  5.789   -46.359 1.00  40.26 ? 304  HIS A C   1 
ATOM   2244 O O   . HIS A 1 304 ? -8.552  5.414   -46.222 1.00  40.32 ? 304  HIS A O   1 
ATOM   2245 C CB  . HIS A 1 304 ? -11.835 4.443   -46.275 1.00  39.08 ? 304  HIS A CB  1 
ATOM   2246 C CG  . HIS A 1 304 ? -11.221 3.333   -47.068 1.00  38.50 ? 304  HIS A CG  1 
ATOM   2247 N ND1 . HIS A 1 304 ? -10.710 2.196   -46.483 1.00  38.87 ? 304  HIS A ND1 1 
ATOM   2248 C CD2 . HIS A 1 304 ? -11.023 3.190   -48.396 1.00  37.12 ? 304  HIS A CD2 1 
ATOM   2249 C CE1 . HIS A 1 304 ? -10.235 1.393   -47.416 1.00  36.70 ? 304  HIS A CE1 1 
ATOM   2250 N NE2 . HIS A 1 304 ? -10.414 1.974   -48.585 1.00  37.72 ? 304  HIS A NE2 1 
ATOM   2251 N N   . ASN A 1 305 ? -10.135 6.727   -47.226 1.00  40.60 ? 305  ASN A N   1 
ATOM   2252 C CA  . ASN A 1 305 ? -9.305  7.223   -48.319 1.00  41.04 ? 305  ASN A CA  1 
ATOM   2253 C C   . ASN A 1 305 ? -8.177  8.168   -47.949 1.00  41.41 ? 305  ASN A C   1 
ATOM   2254 O O   . ASN A 1 305 ? -7.367  8.506   -48.803 1.00  42.00 ? 305  ASN A O   1 
ATOM   2255 C CB  . ASN A 1 305 ? -10.179 7.924   -49.360 1.00  41.11 ? 305  ASN A CB  1 
ATOM   2256 C CG  . ASN A 1 305 ? -11.150 6.986   -50.047 1.00  41.45 ? 305  ASN A CG  1 
ATOM   2257 O OD1 . ASN A 1 305 ? -10.875 5.799   -50.231 1.00  42.09 ? 305  ASN A OD1 1 
ATOM   2258 N ND2 . ASN A 1 305 ? -12.301 7.524   -50.443 1.00  41.88 ? 305  ASN A ND2 1 
ATOM   2259 N N   . GLY A 1 306 ? -8.122  8.621   -46.707 1.00  41.84 ? 306  GLY A N   1 
ATOM   2260 C CA  . GLY A 1 306 ? -7.135  9.631   -46.329 1.00  42.58 ? 306  GLY A CA  1 
ATOM   2261 C C   . GLY A 1 306 ? -7.529  11.041  -46.760 1.00  43.12 ? 306  GLY A C   1 
ATOM   2262 O O   . GLY A 1 306 ? -6.706  11.970  -46.735 1.00  42.86 ? 306  GLY A O   1 
ATOM   2263 N N   . GLU A 1 307 ? -8.781  11.206  -47.178 1.00  43.95 ? 307  GLU A N   1 
ATOM   2264 C CA  . GLU A 1 307 ? -9.290  12.535  -47.518 1.00  45.06 ? 307  GLU A CA  1 
ATOM   2265 C C   . GLU A 1 307 ? -9.919  13.186  -46.291 1.00  45.48 ? 307  GLU A C   1 
ATOM   2266 O O   . GLU A 1 307 ? -10.386 12.499  -45.364 1.00  45.93 ? 307  GLU A O   1 
ATOM   2267 C CB  . GLU A 1 307 ? -10.271 12.485  -48.708 1.00  45.06 ? 307  GLU A CB  1 
ATOM   2268 C CG  . GLU A 1 307 ? -11.168 13.741  -48.906 1.00  47.36 ? 307  GLU A CG  1 
ATOM   2269 C CD  . GLU A 1 307 ? -10.445 15.041  -49.381 1.00  49.74 ? 307  GLU A CD  1 
ATOM   2270 O OE1 . GLU A 1 307 ? -9.254  15.271  -49.070 1.00  50.54 ? 307  GLU A OE1 1 
ATOM   2271 O OE2 . GLU A 1 307 ? -11.101 15.865  -50.053 1.00  50.27 ? 307  GLU A OE2 1 
ATOM   2272 N N   . SER A 1 308 ? -9.919  14.515  -46.297 1.00  45.49 ? 308  SER A N   1 
ATOM   2273 C CA  . SER A 1 308 ? -10.398 15.310  -45.186 1.00  46.20 ? 308  SER A CA  1 
ATOM   2274 C C   . SER A 1 308 ? -11.808 14.909  -44.703 1.00  46.25 ? 308  SER A C   1 
ATOM   2275 O O   . SER A 1 308 ? -12.637 14.435  -45.479 1.00  46.40 ? 308  SER A O   1 
ATOM   2276 C CB  . SER A 1 308 ? -10.353 16.793  -45.583 1.00  46.51 ? 308  SER A CB  1 
ATOM   2277 O OG  . SER A 1 308 ? -10.519 17.657  -44.460 1.00  48.05 ? 308  SER A OG  1 
ATOM   2278 N N   . VAL A 1 309 ? -12.048 15.079  -43.405 1.00  46.32 ? 309  VAL A N   1 
ATOM   2279 C CA  . VAL A 1 309 ? -13.373 14.876  -42.806 1.00  46.27 ? 309  VAL A CA  1 
ATOM   2280 C C   . VAL A 1 309 ? -13.856 16.205  -42.211 1.00  46.14 ? 309  VAL A C   1 
ATOM   2281 O O   . VAL A 1 309 ? -15.065 16.455  -42.099 1.00  46.55 ? 309  VAL A O   1 
ATOM   2282 C CB  . VAL A 1 309 ? -13.337 13.790  -41.688 1.00  46.17 ? 309  VAL A CB  1 
ATOM   2283 C CG1 . VAL A 1 309 ? -14.722 13.553  -41.135 1.00  45.95 ? 309  VAL A CG1 1 
ATOM   2284 C CG2 . VAL A 1 309 ? -12.738 12.466  -42.214 1.00  46.77 ? 309  VAL A CG2 1 
ATOM   2285 N N   . SER A 1 310 ? -12.894 17.047  -41.834 0.010 45.52 ? 310  SER A N   1 
ATOM   2286 C CA  . SER A 1 310 ? -13.174 18.334  -41.207 0.010 44.97 ? 310  SER A CA  1 
ATOM   2287 C C   . SER A 1 310 ? -14.093 19.196  -42.059 0.010 44.66 ? 310  SER A C   1 
ATOM   2288 O O   . SER A 1 310 ? -14.795 20.058  -41.528 0.010 44.60 ? 310  SER A O   1 
ATOM   2289 C CB  . SER A 1 310 ? -11.878 19.089  -40.903 0.010 44.96 ? 310  SER A CB  1 
ATOM   2290 O OG  . SER A 1 310 ? -11.211 19.457  -42.097 0.010 44.91 ? 310  SER A OG  1 
ATOM   2291 N N   . TYR A 1 311 ? -14.111 18.978  -43.372 0.20  44.34 ? 311  TYR A N   1 
ATOM   2292 C CA  . TYR A 1 311 ? -15.093 19.710  -44.141 0.20  44.10 ? 311  TYR A CA  1 
ATOM   2293 C C   . TYR A 1 311 ? -16.493 19.585  -43.574 0.20  44.03 ? 311  TYR A C   1 
ATOM   2294 O O   . TYR A 1 311 ? -17.147 20.596  -43.301 0.20  43.96 ? 311  TYR A O   1 
ATOM   2295 C CB  . TYR A 1 311 ? -15.309 19.219  -45.576 0.20  43.99 ? 311  TYR A CB  1 
ATOM   2296 C CG  . TYR A 1 311 ? -16.680 19.697  -46.029 0.20  43.80 ? 311  TYR A CG  1 
ATOM   2297 C CD1 . TYR A 1 311 ? -17.787 19.504  -45.216 0.20  43.78 ? 311  TYR A CD1 1 
ATOM   2298 C CD2 . TYR A 1 311 ? -16.864 20.398  -47.206 0.20  43.55 ? 311  TYR A CD2 1 
ATOM   2299 C CE1 . TYR A 1 311 ? -19.039 19.948  -45.564 0.20  43.62 ? 311  TYR A CE1 1 
ATOM   2300 C CE2 . TYR A 1 311 ? -18.129 20.853  -47.570 0.20  43.42 ? 311  TYR A CE2 1 
ATOM   2301 C CZ  . TYR A 1 311 ? -19.211 20.620  -46.738 0.20  43.51 ? 311  TYR A CZ  1 
ATOM   2302 O OH  . TYR A 1 311 ? -20.473 21.056  -47.075 0.20  43.17 ? 311  TYR A OH  1 
ATOM   2303 N N   . LEU A 1 312 ? -16.921 18.330  -43.368 1.00  44.03 ? 312  LEU A N   1 
ATOM   2304 C CA  . LEU A 1 312 ? -18.330 17.977  -43.143 1.00  44.14 ? 312  LEU A CA  1 
ATOM   2305 C C   . LEU A 1 312 ? -18.787 18.905  -41.998 1.00  44.24 ? 312  LEU A C   1 
ATOM   2306 O O   . LEU A 1 312 ? -19.943 19.328  -41.934 1.00  44.56 ? 312  LEU A O   1 
ATOM   2307 C CB  . LEU A 1 312 ? -18.543 16.455  -43.026 1.00  44.22 ? 312  LEU A CB  1 
ATOM   2308 C CG  . LEU A 1 312 ? -18.089 15.518  -44.173 1.00  44.47 ? 312  LEU A CG  1 
ATOM   2309 C CD1 . LEU A 1 312 ? -18.231 14.037  -43.808 1.00  44.22 ? 312  LEU A CD1 1 
ATOM   2310 C CD2 . LEU A 1 312 ? -18.810 15.785  -45.483 1.00  44.70 ? 312  LEU A CD2 1 
ATOM   2311 N N   . PHE A 1 313 ? -17.852 19.235  -41.112 0.40  43.88 ? 313  PHE A N   1 
ATOM   2312 C CA  . PHE A 1 313 ? -18.141 20.074  -39.957 0.40  43.46 ? 313  PHE A CA  1 
ATOM   2313 C C   . PHE A 1 313 ? -19.001 21.309  -40.202 0.40  43.38 ? 313  PHE A C   1 
ATOM   2314 O O   . PHE A 1 313 ? -19.842 21.663  -39.375 0.40  43.27 ? 313  PHE A O   1 
ATOM   2315 C CB  . PHE A 1 313 ? -16.837 20.458  -39.251 0.40  43.38 ? 313  PHE A CB  1 
ATOM   2316 C CG  . PHE A 1 313 ? -16.002 19.278  -38.840 0.40  42.72 ? 313  PHE A CG  1 
ATOM   2317 C CD1 . PHE A 1 313 ? -14.694 19.448  -38.430 0.40  42.38 ? 313  PHE A CD1 1 
ATOM   2318 C CD2 . PHE A 1 313 ? -16.527 17.999  -38.872 0.40  42.12 ? 313  PHE A CD2 1 
ATOM   2319 C CE1 . PHE A 1 313 ? -13.930 18.368  -38.046 0.40  42.74 ? 313  PHE A CE1 1 
ATOM   2320 C CE2 . PHE A 1 313 ? -15.769 16.916  -38.491 0.40  42.45 ? 313  PHE A CE2 1 
ATOM   2321 C CZ  . PHE A 1 313 ? -14.468 17.098  -38.080 0.40  42.64 ? 313  PHE A CZ  1 
ATOM   2322 N N   . ASN B 1 3   ? -11.598 -0.315  7.594   0.40  25.24 ? 3    ASN B N   1 
ATOM   2323 C CA  . ASN B 1 3   ? -10.796 -0.512  6.353   0.40  25.44 ? 3    ASN B CA  1 
ATOM   2324 C C   . ASN B 1 3   ? -11.598 -1.237  5.268   0.40  25.47 ? 3    ASN B C   1 
ATOM   2325 O O   . ASN B 1 3   ? -11.590 -0.825  4.122   0.40  25.30 ? 3    ASN B O   1 
ATOM   2326 C CB  . ASN B 1 3   ? -9.490  -1.259  6.665   0.40  25.38 ? 3    ASN B CB  1 
ATOM   2327 C CG  . ASN B 1 3   ? -8.247  -0.532  6.146   0.40  24.82 ? 3    ASN B CG  1 
ATOM   2328 O OD1 . ASN B 1 3   ? -7.440  -0.039  6.930   0.40  24.19 ? 3    ASN B OD1 1 
ATOM   2329 N ND2 . ASN B 1 3   ? -8.095  -0.464  4.831   0.40  24.18 ? 3    ASN B ND2 1 
ATOM   2330 N N   . ILE B 1 4   ? -12.302 -2.299  5.652   1.00  25.78 ? 4    ILE B N   1 
ATOM   2331 C CA  . ILE B 1 4   ? -13.126 -3.108  4.741   1.00  26.54 ? 4    ILE B CA  1 
ATOM   2332 C C   . ILE B 1 4   ? -14.527 -2.511  4.477   1.00  26.65 ? 4    ILE B C   1 
ATOM   2333 O O   . ILE B 1 4   ? -15.157 -1.971  5.374   1.00  26.45 ? 4    ILE B O   1 
ATOM   2334 C CB  . ILE B 1 4   ? -13.232 -4.594  5.242   1.00  26.82 ? 4    ILE B CB  1 
ATOM   2335 C CG1 . ILE B 1 4   ? -13.336 -5.597  4.074   1.00  27.53 ? 4    ILE B CG1 1 
ATOM   2336 C CG2 . ILE B 1 4   ? -14.368 -4.780  6.271   1.00  27.32 ? 4    ILE B CG2 1 
ATOM   2337 C CD1 . ILE B 1 4   ? -14.765 -5.918  3.588   1.00  28.77 ? 4    ILE B CD1 1 
ATOM   2338 N N   . LYS B 1 5   ? -14.983 -2.593  3.231   0.40  27.07 ? 5    LYS B N   1 
ATOM   2339 C CA  . LYS B 1 5   ? -16.293 -2.080  2.847   0.40  27.44 ? 5    LYS B CA  1 
ATOM   2340 C C   . LYS B 1 5   ? -16.838 -2.925  1.708   0.40  27.96 ? 5    LYS B C   1 
ATOM   2341 O O   . LYS B 1 5   ? -16.162 -3.154  0.714   0.40  27.56 ? 5    LYS B O   1 
ATOM   2342 C CB  . LYS B 1 5   ? -16.212 -0.611  2.418   0.40  27.29 ? 5    LYS B CB  1 
ATOM   2343 C CG  . LYS B 1 5   ? -17.481 0.181   2.682   0.40  26.78 ? 5    LYS B CG  1 
ATOM   2344 C CD  . LYS B 1 5   ? -17.382 0.935   4.000   0.40  26.81 ? 5    LYS B CD  1 
ATOM   2345 C CE  . LYS B 1 5   ? -18.505 0.557   4.971   0.40  26.80 ? 5    LYS B CE  1 
ATOM   2346 N NZ  . LYS B 1 5   ? -19.845 1.093   4.608   0.40  25.92 ? 5    LYS B NZ  1 
ATOM   2347 N N   . ILE B 1 6   ? -18.071 -3.384  1.874   1.00  28.95 ? 6    ILE B N   1 
ATOM   2348 C CA  . ILE B 1 6   ? -18.730 -4.272  0.928   1.00  29.99 ? 6    ILE B CA  1 
ATOM   2349 C C   . ILE B 1 6   ? -19.918 -3.592  0.275   1.00  30.71 ? 6    ILE B C   1 
ATOM   2350 O O   . ILE B 1 6   ? -20.781 -3.055  0.944   1.00  31.18 ? 6    ILE B O   1 
ATOM   2351 C CB  . ILE B 1 6   ? -19.244 -5.522  1.639   1.00  29.82 ? 6    ILE B CB  1 
ATOM   2352 C CG1 . ILE B 1 6   ? -18.060 -6.377  2.064   1.00  30.98 ? 6    ILE B CG1 1 
ATOM   2353 C CG2 . ILE B 1 6   ? -20.201 -6.325  0.745   1.00  30.20 ? 6    ILE B CG2 1 
ATOM   2354 C CD1 . ILE B 1 6   ? -18.406 -7.326  3.159   1.00  34.37 ? 6    ILE B CD1 1 
ATOM   2355 N N   . PHE B 1 7   ? -19.963 -3.621  -1.042  1.00  31.90 ? 7    PHE B N   1 
ATOM   2356 C CA  . PHE B 1 7   ? -21.110 -3.086  -1.761  1.00  32.96 ? 7    PHE B CA  1 
ATOM   2357 C C   . PHE B 1 7   ? -21.756 -4.143  -2.653  1.00  34.09 ? 7    PHE B C   1 
ATOM   2358 O O   . PHE B 1 7   ? -21.083 -5.024  -3.217  1.00  34.53 ? 7    PHE B O   1 
ATOM   2359 C CB  . PHE B 1 7   ? -20.695 -1.910  -2.642  1.00  32.66 ? 7    PHE B CB  1 
ATOM   2360 C CG  . PHE B 1 7   ? -20.283 -0.681  -1.885  1.00  30.42 ? 7    PHE B CG  1 
ATOM   2361 C CD1 . PHE B 1 7   ? -18.978 -0.524  -1.436  1.00  28.96 ? 7    PHE B CD1 1 
ATOM   2362 C CD2 . PHE B 1 7   ? -21.190 0.340   -1.674  1.00  27.92 ? 7    PHE B CD2 1 
ATOM   2363 C CE1 . PHE B 1 7   ? -18.592 0.631   -0.766  1.00  29.19 ? 7    PHE B CE1 1 
ATOM   2364 C CE2 . PHE B 1 7   ? -20.822 1.493   -1.007  1.00  28.56 ? 7    PHE B CE2 1 
ATOM   2365 C CZ  . PHE B 1 7   ? -19.514 1.645   -0.550  1.00  28.85 ? 7    PHE B CZ  1 
ATOM   2366 N N   . SER B 1 8   ? -23.064 -4.015  -2.808  1.00  35.42 ? 8    SER B N   1 
ATOM   2367 C CA  . SER B 1 8   ? -23.849 -4.935  -3.602  1.00  36.80 ? 8    SER B CA  1 
ATOM   2368 C C   . SER B 1 8   ? -24.104 -4.265  -4.953  1.00  37.65 ? 8    SER B C   1 
ATOM   2369 O O   . SER B 1 8   ? -24.004 -3.041  -5.078  1.00  37.45 ? 8    SER B O   1 
ATOM   2370 C CB  . SER B 1 8   ? -25.100 -5.331  -2.801  1.00  37.00 ? 8    SER B CB  1 
ATOM   2371 O OG  . SER B 1 8   ? -26.179 -5.714  -3.660  1.00  37.84 ? 8    SER B OG  1 
ATOM   2372 N N   . GLY B 1 9   ? -24.427 -5.071  -5.964  1.00  38.98 ? 9    GLY B N   1 
ATOM   2373 C CA  . GLY B 1 9   ? -24.892 -4.555  -7.284  1.00  40.37 ? 9    GLY B CA  1 
ATOM   2374 C C   . GLY B 1 9   ? -26.424 -4.690  -7.322  1.00  40.77 ? 9    GLY B C   1 
ATOM   2375 O O   . GLY B 1 9   ? -26.988 -5.585  -6.687  1.00  41.41 ? 9    GLY B O   1 
ATOM   2376 N N   . SER B 1 10  ? -27.096 -3.811  -8.062  0.10  40.90 ? 10   SER B N   1 
ATOM   2377 C CA  . SER B 1 10  ? -28.567 -3.819  -8.162  0.10  40.97 ? 10   SER B CA  1 
ATOM   2378 C C   . SER B 1 10  ? -29.385 -3.916  -6.881  0.10  41.06 ? 10   SER B C   1 
ATOM   2379 O O   . SER B 1 10  ? -29.180 -3.152  -5.937  0.10  41.07 ? 10   SER B O   1 
ATOM   2380 C CB  . SER B 1 10  ? -28.984 -4.940  -9.121  0.10  40.98 ? 10   SER B CB  1 
ATOM   2381 O OG  . SER B 1 10  ? -29.323 -6.112  -8.396  0.10  40.94 ? 10   SER B OG  1 
ATOM   2382 N N   . SER B 1 11  ? -30.308 -4.873  -6.861  0.20  41.16 ? 11   SER B N   1 
ATOM   2383 C CA  . SER B 1 11  ? -31.178 -5.067  -5.711  0.20  41.30 ? 11   SER B CA  1 
ATOM   2384 C C   . SER B 1 11  ? -31.338 -6.555  -5.434  0.20  41.42 ? 11   SER B C   1 
ATOM   2385 O O   . SER B 1 11  ? -32.122 -6.942  -4.564  0.20  41.40 ? 11   SER B O   1 
ATOM   2386 C CB  . SER B 1 11  ? -32.549 -4.398  -5.829  0.20  41.25 ? 11   SER B CB  1 
ATOM   2387 O OG  . SER B 1 11  ? -33.285 -4.550  -4.625  0.20  41.18 ? 11   SER B OG  1 
ATOM   2388 N N   . HIS B 1 12  ? -30.607 -7.393  -6.168  0.76  41.55 ? 12   HIS B N   1 
ATOM   2389 C CA  . HIS B 1 12  ? -30.535 -8.802  -5.789  0.76  41.53 ? 12   HIS B CA  1 
ATOM   2390 C C   . HIS B 1 12  ? -29.489 -8.885  -4.693  0.76  41.37 ? 12   HIS B C   1 
ATOM   2391 O O   . HIS B 1 12  ? -28.346 -9.306  -4.919  0.76  41.21 ? 12   HIS B O   1 
ATOM   2392 C CB  . HIS B 1 12  ? -30.181 -9.697  -6.969  0.76  41.69 ? 12   HIS B CB  1 
ATOM   2393 C CG  . HIS B 1 12  ? -31.311 -9.915  -7.926  0.76  42.35 ? 12   HIS B CG  1 
ATOM   2394 N ND1 . HIS B 1 12  ? -32.047 -11.080 -7.956  0.76  43.40 ? 12   HIS B ND1 1 
ATOM   2395 C CD2 . HIS B 1 12  ? -31.819 -9.123  -8.901  0.76  43.23 ? 12   HIS B CD2 1 
ATOM   2396 C CE1 . HIS B 1 12  ? -32.964 -10.995 -8.906  0.76  44.02 ? 12   HIS B CE1 1 
ATOM   2397 N NE2 . HIS B 1 12  ? -32.846 -9.819  -9.496  0.76  43.72 ? 12   HIS B NE2 1 
ATOM   2398 N N   . GLN B 1 13  ? -29.903 -8.462  -3.501  1.00  41.08 ? 13   GLN B N   1 
ATOM   2399 C CA  . GLN B 1 13  ? -28.988 -8.241  -2.408  1.00  40.87 ? 13   GLN B CA  1 
ATOM   2400 C C   . GLN B 1 13  ? -28.951 -9.357  -1.358  1.00  40.17 ? 13   GLN B C   1 
ATOM   2401 O O   . GLN B 1 13  ? -28.359 -9.163  -0.300  1.00  40.71 ? 13   GLN B O   1 
ATOM   2402 C CB  . GLN B 1 13  ? -29.269 -6.876  -1.757  1.00  41.18 ? 13   GLN B CB  1 
ATOM   2403 C CG  . GLN B 1 13  ? -29.110 -5.662  -2.702  1.00  42.19 ? 13   GLN B CG  1 
ATOM   2404 C CD  . GLN B 1 13  ? -29.000 -4.333  -1.942  1.00  44.66 ? 13   GLN B CD  1 
ATOM   2405 O OE1 . GLN B 1 13  ? -27.972 -3.642  -1.996  1.00  45.89 ? 13   GLN B OE1 1 
ATOM   2406 N NE2 . GLN B 1 13  ? -30.059 -3.980  -1.218  1.00  45.82 ? 13   GLN B NE2 1 
ATOM   2407 N N   . ASP B 1 14  ? -29.519 -10.526 -1.643  0.40  39.20 ? 14   ASP B N   1 
ATOM   2408 C CA  . ASP B 1 14  ? -29.498 -11.594 -0.642  0.40  38.47 ? 14   ASP B CA  1 
ATOM   2409 C C   . ASP B 1 14  ? -28.071 -12.034 -0.321  0.40  37.84 ? 14   ASP B C   1 
ATOM   2410 O O   . ASP B 1 14  ? -27.626 -11.917 0.816   0.40  37.55 ? 14   ASP B O   1 
ATOM   2411 C CB  . ASP B 1 14  ? -30.355 -12.794 -1.053  0.40  38.58 ? 14   ASP B CB  1 
ATOM   2412 C CG  . ASP B 1 14  ? -30.901 -13.549 0.145   0.40  38.63 ? 14   ASP B CG  1 
ATOM   2413 O OD1 . ASP B 1 14  ? -32.033 -13.242 0.576   0.40  38.50 ? 14   ASP B OD1 1 
ATOM   2414 O OD2 . ASP B 1 14  ? -30.202 -14.447 0.658   0.40  39.07 ? 14   ASP B OD2 1 
ATOM   2415 N N   . LEU B 1 15  ? -27.354 -12.504 -1.340  1.00  37.51 ? 15   LEU B N   1 
ATOM   2416 C CA  . LEU B 1 15  ? -25.992 -13.032 -1.186  1.00  36.61 ? 15   LEU B CA  1 
ATOM   2417 C C   . LEU B 1 15  ? -25.077 -11.963 -0.605  1.00  36.40 ? 15   LEU B C   1 
ATOM   2418 O O   . LEU B 1 15  ? -24.286 -12.222 0.313   1.00  36.37 ? 15   LEU B O   1 
ATOM   2419 C CB  . LEU B 1 15  ? -25.446 -13.487 -2.536  1.00  36.08 ? 15   LEU B CB  1 
ATOM   2420 C CG  . LEU B 1 15  ? -24.453 -14.654 -2.678  1.00  35.84 ? 15   LEU B CG  1 
ATOM   2421 C CD1 . LEU B 1 15  ? -23.341 -14.238 -3.654  1.00  34.21 ? 15   LEU B CD1 1 
ATOM   2422 C CD2 . LEU B 1 15  ? -23.848 -15.173 -1.364  1.00  33.97 ? 15   LEU B CD2 1 
ATOM   2423 N N   . SER B 1 16  ? -25.205 -10.757 -1.150  1.00  36.05 ? 16   SER B N   1 
ATOM   2424 C CA  . SER B 1 16  ? -24.479 -9.593  -0.676  1.00  35.67 ? 16   SER B CA  1 
ATOM   2425 C C   . SER B 1 16  ? -24.668 -9.396  0.810   1.00  35.42 ? 16   SER B C   1 
ATOM   2426 O O   . SER B 1 16  ? -23.687 -9.208  1.539   1.00  35.27 ? 16   SER B O   1 
ATOM   2427 C CB  . SER B 1 16  ? -24.973 -8.352  -1.402  1.00  35.72 ? 16   SER B CB  1 
ATOM   2428 O OG  . SER B 1 16  ? -24.610 -8.407  -2.763  1.00  36.52 ? 16   SER B OG  1 
ATOM   2429 N N   . GLN B 1 17  ? -25.935 -9.441  1.240   1.00  35.17 ? 17   GLN B N   1 
ATOM   2430 C CA  . GLN B 1 17  ? -26.311 -9.162  2.620   1.00  34.69 ? 17   GLN B CA  1 
ATOM   2431 C C   . GLN B 1 17  ? -25.905 -10.298 3.531   1.00  34.05 ? 17   GLN B C   1 
ATOM   2432 O O   . GLN B 1 17  ? -25.479 -10.051 4.640   1.00  34.10 ? 17   GLN B O   1 
ATOM   2433 C CB  . GLN B 1 17  ? -27.803 -8.845  2.736   1.00  34.93 ? 17   GLN B CB  1 
ATOM   2434 C CG  . GLN B 1 17  ? -28.311 -8.532  4.149   1.00  37.51 ? 17   GLN B CG  1 
ATOM   2435 C CD  . GLN B 1 17  ? -27.608 -7.330  4.805   1.00  40.75 ? 17   GLN B CD  1 
ATOM   2436 O OE1 . GLN B 1 17  ? -27.709 -6.187  4.315   1.00  41.73 ? 17   GLN B OE1 1 
ATOM   2437 N NE2 . GLN B 1 17  ? -26.899 -7.585  5.921   1.00  38.82 ? 17   GLN B NE2 1 
ATOM   2438 N N   . LYS B 1 18  ? -26.000 -11.537 3.062   1.00  33.90 ? 18   LYS B N   1 
ATOM   2439 C CA  . LYS B 1 18  ? -25.516 -12.677 3.850   1.00  34.17 ? 18   LYS B CA  1 
ATOM   2440 C C   . LYS B 1 18  ? -23.989 -12.624 4.077   1.00  34.29 ? 18   LYS B C   1 
ATOM   2441 O O   . LYS B 1 18  ? -23.505 -12.926 5.178   1.00  34.28 ? 18   LYS B O   1 
ATOM   2442 C CB  . LYS B 1 18  ? -25.905 -14.009 3.202   1.00  34.47 ? 18   LYS B CB  1 
ATOM   2443 C CG  . LYS B 1 18  ? -27.302 -14.533 3.539   1.00  34.85 ? 18   LYS B CG  1 
ATOM   2444 C CD  . LYS B 1 18  ? -27.470 -15.955 2.986   1.00  36.59 ? 18   LYS B CD  1 
ATOM   2445 C CE  . LYS B 1 18  ? -28.945 -16.364 2.801   1.00  37.54 ? 18   LYS B CE  1 
ATOM   2446 N NZ  . LYS B 1 18  ? -29.058 -17.657 2.032   1.00  37.57 ? 18   LYS B NZ  1 
ATOM   2447 N N   . ILE B 1 19  ? -23.246 -12.238 3.032   1.00  33.93 ? 19   ILE B N   1 
ATOM   2448 C CA  . ILE B 1 19  ? -21.793 -12.098 3.093   1.00  33.19 ? 19   ILE B CA  1 
ATOM   2449 C C   . ILE B 1 19  ? -21.424 -11.008 4.079   1.00  33.10 ? 19   ILE B C   1 
ATOM   2450 O O   . ILE B 1 19  ? -20.429 -11.131 4.813   1.00  33.47 ? 19   ILE B O   1 
ATOM   2451 C CB  . ILE B 1 19  ? -21.201 -11.755 1.713   1.00  33.07 ? 19   ILE B CB  1 
ATOM   2452 C CG1 . ILE B 1 19  ? -21.397 -12.921 0.733   1.00  32.32 ? 19   ILE B CG1 1 
ATOM   2453 C CG2 . ILE B 1 19  ? -19.741 -11.379 1.842   1.00  33.21 ? 19   ILE B CG2 1 
ATOM   2454 C CD1 . ILE B 1 19  ? -21.311 -12.547 -0.757  1.00  28.67 ? 19   ILE B CD1 1 
ATOM   2455 N N   . ALA B 1 20  ? -22.228 -9.943  4.087   1.00  32.55 ? 20   ALA B N   1 
ATOM   2456 C CA  . ALA B 1 20  ? -22.010 -8.813  4.989   1.00  32.25 ? 20   ALA B CA  1 
ATOM   2457 C C   . ALA B 1 20  ? -22.343 -9.159  6.442   1.00  32.13 ? 20   ALA B C   1 
ATOM   2458 O O   . ALA B 1 20  ? -21.623 -8.758  7.350   1.00  32.08 ? 20   ALA B O   1 
ATOM   2459 C CB  . ALA B 1 20  ? -22.791 -7.617  4.536   1.00  31.85 ? 20   ALA B CB  1 
ATOM   2460 N N   . ASP B 1 21  ? -23.426 -9.910  6.640   0.40  32.17 ? 21   ASP B N   1 
ATOM   2461 C CA  . ASP B 1 21  ? -23.833 -10.387 7.960   0.40  32.28 ? 21   ASP B CA  1 
ATOM   2462 C C   . ASP B 1 21  ? -22.713 -11.193 8.610   0.40  32.85 ? 21   ASP B C   1 
ATOM   2463 O O   . ASP B 1 21  ? -22.409 -11.018 9.787   0.40  32.66 ? 21   ASP B O   1 
ATOM   2464 C CB  . ASP B 1 21  ? -25.093 -11.252 7.846   0.40  31.94 ? 21   ASP B CB  1 
ATOM   2465 C CG  . ASP B 1 21  ? -26.352 -10.431 7.658   0.40  31.45 ? 21   ASP B CG  1 
ATOM   2466 O OD1 . ASP B 1 21  ? -26.375 -9.277  8.142   0.40  32.17 ? 21   ASP B OD1 1 
ATOM   2467 O OD2 . ASP B 1 21  ? -27.317 -10.934 7.039   0.40  29.07 ? 21   ASP B OD2 1 
ATOM   2468 N N   . ARG B 1 22  ? -22.085 -12.050 7.810   1.00  33.78 ? 22   ARG B N   1 
ATOM   2469 C CA  . ARG B 1 22  ? -21.085 -13.001 8.292   1.00  34.64 ? 22   ARG B CA  1 
ATOM   2470 C C   . ARG B 1 22  ? -19.737 -12.339 8.618   1.00  34.69 ? 22   ARG B C   1 
ATOM   2471 O O   . ARG B 1 22  ? -18.897 -12.924 9.317   1.00  34.75 ? 22   ARG B O   1 
ATOM   2472 C CB  . ARG B 1 22  ? -20.932 -14.163 7.301   1.00  34.55 ? 22   ARG B CB  1 
ATOM   2473 C CG  . ARG B 1 22  ? -22.196 -15.018 7.226   1.00  37.55 ? 22   ARG B CG  1 
ATOM   2474 C CD  . ARG B 1 22  ? -22.072 -16.179 6.253   1.00  42.29 ? 22   ARG B CD  1 
ATOM   2475 N NE  . ARG B 1 22  ? -21.663 -17.422 6.904   1.00  46.00 ? 22   ARG B NE  1 
ATOM   2476 C CZ  . ARG B 1 22  ? -22.457 -18.480 7.081   1.00  48.09 ? 22   ARG B CZ  1 
ATOM   2477 N NH1 . ARG B 1 22  ? -23.721 -18.454 6.657   1.00  48.62 ? 22   ARG B NH1 1 
ATOM   2478 N NH2 . ARG B 1 22  ? -21.985 -19.571 7.683   1.00  49.18 ? 22   ARG B NH2 1 
ATOM   2479 N N   . LEU B 1 23  ? -19.549 -11.111 8.128   1.00  34.50 ? 23   LEU B N   1 
ATOM   2480 C CA  . LEU B 1 23  ? -18.363 -10.329 8.463   1.00  34.02 ? 23   LEU B CA  1 
ATOM   2481 C C   . LEU B 1 23  ? -18.663 -9.280  9.529   1.00  33.76 ? 23   LEU B C   1 
ATOM   2482 O O   . LEU B 1 23  ? -17.751 -8.619  10.007  1.00  34.15 ? 23   LEU B O   1 
ATOM   2483 C CB  . LEU B 1 23  ? -17.775 -9.662  7.218   1.00  34.10 ? 23   LEU B CB  1 
ATOM   2484 C CG  . LEU B 1 23  ? -17.280 -10.541 6.062   1.00  33.89 ? 23   LEU B CG  1 
ATOM   2485 C CD1 . LEU B 1 23  ? -17.181 -9.704  4.787   1.00  33.92 ? 23   LEU B CD1 1 
ATOM   2486 C CD2 . LEU B 1 23  ? -15.923 -11.167 6.378   1.00  33.02 ? 23   LEU B CD2 1 
ATOM   2487 N N   . GLY B 1 24  ? -19.934 -9.142  9.902   1.00  33.27 ? 24   GLY B N   1 
ATOM   2488 C CA  . GLY B 1 24  ? -20.346 -8.194  10.939  1.00  33.07 ? 24   GLY B CA  1 
ATOM   2489 C C   . GLY B 1 24  ? -20.430 -6.775  10.417  1.00  33.10 ? 24   GLY B C   1 
ATOM   2490 O O   . GLY B 1 24  ? -20.103 -5.826  11.110  1.00  32.89 ? 24   GLY B O   1 
ATOM   2491 N N   . LEU B 1 25  ? -20.883 -6.648  9.177   1.00  33.44 ? 25   LEU B N   1 
ATOM   2492 C CA  . LEU B 1 25  ? -20.874 -5.387  8.451   1.00  33.58 ? 25   LEU B CA  1 
ATOM   2493 C C   . LEU B 1 25  ? -22.214 -5.117  7.822   1.00  33.95 ? 25   LEU B C   1 
ATOM   2494 O O   . LEU B 1 25  ? -22.983 -6.042  7.556   1.00  34.09 ? 25   LEU B O   1 
ATOM   2495 C CB  . LEU B 1 25  ? -19.853 -5.436  7.316   1.00  33.19 ? 25   LEU B CB  1 
ATOM   2496 C CG  . LEU B 1 25  ? -18.359 -5.442  7.606   1.00  32.31 ? 25   LEU B CG  1 
ATOM   2497 C CD1 . LEU B 1 25  ? -17.667 -5.318  6.270   1.00  32.43 ? 25   LEU B CD1 1 
ATOM   2498 C CD2 . LEU B 1 25  ? -17.958 -4.300  8.527   1.00  30.62 ? 25   LEU B CD2 1 
ATOM   2499 N N   . GLU B 1 26  ? -22.481 -3.843  7.571   0.94  34.36 ? 26   GLU B N   1 
ATOM   2500 C CA  . GLU B 1 26  ? -23.652 -3.469  6.818   0.94  35.22 ? 26   GLU B CA  1 
ATOM   2501 C C   . GLU B 1 26  ? -23.201 -3.193  5.402   0.94  34.92 ? 26   GLU B C   1 
ATOM   2502 O O   . GLU B 1 26  ? -22.103 -2.683  5.201   0.94  35.49 ? 26   GLU B O   1 
ATOM   2503 C CB  . GLU B 1 26  ? -24.269 -2.216  7.411   0.94  35.35 ? 26   GLU B CB  1 
ATOM   2504 C CG  . GLU B 1 26  ? -25.058 -2.480  8.658   0.94  37.74 ? 26   GLU B CG  1 
ATOM   2505 C CD  . GLU B 1 26  ? -26.018 -1.352  8.932   0.94  42.03 ? 26   GLU B CD  1 
ATOM   2506 O OE1 . GLU B 1 26  ? -26.048 -0.398  8.102   0.94  43.85 ? 26   GLU B OE1 1 
ATOM   2507 O OE2 . GLU B 1 26  ? -26.733 -1.422  9.966   0.94  41.99 ? 26   GLU B OE2 1 
ATOM   2508 N N   . LEU B 1 27  ? -24.027 -3.520  4.418   1.00  34.38 ? 27   LEU B N   1 
ATOM   2509 C CA  . LEU B 1 27  ? -23.685 -3.141  3.059   1.00  34.25 ? 27   LEU B CA  1 
ATOM   2510 C C   . LEU B 1 27  ? -23.495 -1.635  3.030   1.00  34.79 ? 27   LEU B C   1 
ATOM   2511 O O   . LEU B 1 27  ? -24.217 -0.896  3.720   1.00  34.96 ? 27   LEU B O   1 
ATOM   2512 C CB  . LEU B 1 27  ? -24.773 -3.541  2.056   1.00  33.67 ? 27   LEU B CB  1 
ATOM   2513 C CG  . LEU B 1 27  ? -25.011 -5.022  1.740   1.00  32.05 ? 27   LEU B CG  1 
ATOM   2514 C CD1 . LEU B 1 27  ? -26.168 -5.089  0.784   1.00  33.63 ? 27   LEU B CD1 1 
ATOM   2515 C CD2 . LEU B 1 27  ? -23.801 -5.711  1.144   1.00  31.30 ? 27   LEU B CD2 1 
ATOM   2516 N N   . GLY B 1 28  ? -22.504 -1.187  2.256   1.00  35.24 ? 28   GLY B N   1 
ATOM   2517 C CA  . GLY B 1 28  ? -22.311 0.241   2.000   1.00  35.72 ? 28   GLY B CA  1 
ATOM   2518 C C   . GLY B 1 28  ? -23.518 0.853   1.306   1.00  36.19 ? 28   GLY B C   1 
ATOM   2519 O O   . GLY B 1 28  ? -24.328 0.145   0.698   1.00  35.62 ? 28   GLY B O   1 
ATOM   2520 N N   . LYS B 1 29  ? -23.638 2.172   1.416   1.00  37.16 ? 29   LYS B N   1 
ATOM   2521 C CA  . LYS B 1 29  ? -24.748 2.909   0.820   1.00  38.22 ? 29   LYS B CA  1 
ATOM   2522 C C   . LYS B 1 29  ? -24.479 3.164   -0.659  1.00  38.32 ? 29   LYS B C   1 
ATOM   2523 O O   . LYS B 1 29  ? -23.439 3.712   -1.018  1.00  38.11 ? 29   LYS B O   1 
ATOM   2524 C CB  . LYS B 1 29  ? -24.983 4.234   1.560   1.00  38.55 ? 29   LYS B CB  1 
ATOM   2525 C CG  . LYS B 1 29  ? -24.748 4.177   3.086   1.00  40.44 ? 29   LYS B CG  1 
ATOM   2526 C CD  . LYS B 1 29  ? -25.348 5.405   3.825   1.00  43.85 ? 29   LYS B CD  1 
ATOM   2527 C CE  . LYS B 1 29  ? -25.088 5.400   5.366   1.00  45.26 ? 29   LYS B CE  1 
ATOM   2528 N NZ  . LYS B 1 29  ? -25.423 4.117   6.109   1.00  44.63 ? 29   LYS B NZ  1 
ATOM   2529 N N   . VAL B 1 30  ? -25.419 2.740   -1.503  1.00  38.86 ? 30   VAL B N   1 
ATOM   2530 C CA  . VAL B 1 30  ? -25.336 2.925   -2.947  1.00  39.59 ? 30   VAL B CA  1 
ATOM   2531 C C   . VAL B 1 30  ? -26.669 3.413   -3.471  1.00  40.23 ? 30   VAL B C   1 
ATOM   2532 O O   . VAL B 1 30  ? -27.697 2.780   -3.238  1.00  40.02 ? 30   VAL B O   1 
ATOM   2533 C CB  . VAL B 1 30  ? -25.014 1.598   -3.688  1.00  39.35 ? 30   VAL B CB  1 
ATOM   2534 C CG1 . VAL B 1 30  ? -24.936 1.815   -5.196  1.00  39.01 ? 30   VAL B CG1 1 
ATOM   2535 C CG2 . VAL B 1 30  ? -23.728 1.028   -3.209  1.00  39.91 ? 30   VAL B CG2 1 
ATOM   2536 N N   . VAL B 1 31  ? -26.640 4.533   -4.189  1.00  41.36 ? 31   VAL B N   1 
ATOM   2537 C CA  . VAL B 1 31  ? -27.798 5.002   -4.957  1.00  42.33 ? 31   VAL B CA  1 
ATOM   2538 C C   . VAL B 1 31  ? -27.638 4.509   -6.394  1.00  42.79 ? 31   VAL B C   1 
ATOM   2539 O O   . VAL B 1 31  ? -26.909 5.114   -7.181  1.00  43.07 ? 31   VAL B O   1 
ATOM   2540 C CB  . VAL B 1 31  ? -27.926 6.559   -4.908  1.00  42.44 ? 31   VAL B CB  1 
ATOM   2541 C CG1 . VAL B 1 31  ? -28.848 7.091   -6.017  1.00  42.53 ? 31   VAL B CG1 1 
ATOM   2542 C CG2 . VAL B 1 31  ? -28.394 7.006   -3.526  1.00  41.87 ? 31   VAL B CG2 1 
ATOM   2543 N N   . THR B 1 32  ? -28.312 3.401   -6.709  0.71  43.38 ? 32   THR B N   1 
ATOM   2544 C CA  . THR B 1 32  ? -28.191 2.736   -8.009  0.71  43.91 ? 32   THR B CA  1 
ATOM   2545 C C   . THR B 1 32  ? -29.544 2.585   -8.697  0.71  44.10 ? 32   THR B C   1 
ATOM   2546 O O   . THR B 1 32  ? -30.464 1.976   -8.151  0.71  44.49 ? 32   THR B O   1 
ATOM   2547 C CB  . THR B 1 32  ? -27.481 1.354   -7.892  0.71  43.89 ? 32   THR B CB  1 
ATOM   2548 O OG1 . THR B 1 32  ? -27.486 0.702   -9.168  0.71  44.54 ? 32   THR B OG1 1 
ATOM   2549 C CG2 . THR B 1 32  ? -28.158 0.446   -6.849  0.71  44.12 ? 32   THR B CG2 1 
ATOM   2550 N N   . LYS B 1 33  ? -29.673 3.151   -9.891  0.010 44.34 ? 33   LYS B N   1 
ATOM   2551 C CA  . LYS B 1 33  ? -30.921 3.032   -10.628 0.010 44.53 ? 33   LYS B CA  1 
ATOM   2552 C C   . LYS B 1 33  ? -30.658 3.070   -12.124 0.010 44.73 ? 33   LYS B C   1 
ATOM   2553 O O   . LYS B 1 33  ? -29.597 3.515   -12.567 0.010 44.74 ? 33   LYS B O   1 
ATOM   2554 C CB  . LYS B 1 33  ? -31.886 4.153   -10.237 0.010 44.50 ? 33   LYS B CB  1 
ATOM   2555 C CG  . LYS B 1 33  ? -31.532 5.504   -10.834 0.010 44.46 ? 33   LYS B CG  1 
ATOM   2556 C CD  . LYS B 1 33  ? -32.329 6.618   -10.175 0.010 44.41 ? 33   LYS B CD  1 
ATOM   2557 C CE  . LYS B 1 33  ? -31.873 7.982   -10.666 0.010 44.39 ? 33   LYS B CE  1 
ATOM   2558 N NZ  . LYS B 1 33  ? -32.544 9.090   -9.926  0.010 44.38 ? 33   LYS B NZ  1 
ATOM   2559 N N   . LYS B 1 34  ? -31.631 2.594   -12.894 0.10  45.07 ? 34   LYS B N   1 
ATOM   2560 C CA  . LYS B 1 34  ? -31.564 2.626   -14.346 0.10  45.28 ? 34   LYS B CA  1 
ATOM   2561 C C   . LYS B 1 34  ? -32.314 3.839   -14.893 0.10  44.96 ? 34   LYS B C   1 
ATOM   2562 O O   . LYS B 1 34  ? -33.490 4.065   -14.580 0.10  45.06 ? 34   LYS B O   1 
ATOM   2563 C CB  . LYS B 1 34  ? -32.130 1.343   -14.955 0.10  45.34 ? 34   LYS B CB  1 
ATOM   2564 C CG  . LYS B 1 34  ? -31.128 0.208   -15.058 0.10  47.13 ? 34   LYS B CG  1 
ATOM   2565 C CD  . LYS B 1 34  ? -31.030 -0.346  -16.510 0.10  50.57 ? 34   LYS B CD  1 
ATOM   2566 C CE  . LYS B 1 34  ? -32.386 -0.747  -17.131 0.10  50.88 ? 34   LYS B CE  1 
ATOM   2567 N NZ  . LYS B 1 34  ? -32.295 -0.729  -18.618 0.10  51.75 ? 34   LYS B NZ  1 
ATOM   2568 N N   . PHE B 1 35  ? -31.629 4.615   -15.721 0.010 44.46 ? 35   PHE B N   1 
ATOM   2569 C CA  . PHE B 1 35  ? -32.228 5.798   -16.311 0.010 43.98 ? 35   PHE B CA  1 
ATOM   2570 C C   . PHE B 1 35  ? -33.330 5.439   -17.297 0.010 43.69 ? 35   PHE B C   1 
ATOM   2571 O O   . PHE B 1 35  ? -33.506 4.275   -17.660 0.010 43.64 ? 35   PHE B O   1 
ATOM   2572 C CB  . PHE B 1 35  ? -31.170 6.638   -17.011 0.010 43.97 ? 35   PHE B CB  1 
ATOM   2573 C CG  . PHE B 1 35  ? -30.308 7.426   -16.079 0.010 43.87 ? 35   PHE B CG  1 
ATOM   2574 C CD1 . PHE B 1 35  ? -28.932 7.343   -16.159 0.010 43.81 ? 35   PHE B CD1 1 
ATOM   2575 C CD2 . PHE B 1 35  ? -30.875 8.259   -15.129 0.010 43.81 ? 35   PHE B CD2 1 
ATOM   2576 C CE1 . PHE B 1 35  ? -28.143 8.077   -15.322 0.010 43.76 ? 35   PHE B CE1 1 
ATOM   2577 C CE2 . PHE B 1 35  ? -30.085 8.991   -14.276 0.010 43.78 ? 35   PHE B CE2 1 
ATOM   2578 C CZ  . PHE B 1 35  ? -28.721 8.905   -14.374 0.010 43.75 ? 35   PHE B CZ  1 
ATOM   2579 N N   . SER B 1 36  ? -34.067 6.452   -17.732 0.010 43.35 ? 36   SER B N   1 
ATOM   2580 C CA  . SER B 1 36  ? -35.161 6.241   -18.661 0.010 43.05 ? 36   SER B CA  1 
ATOM   2581 C C   . SER B 1 36  ? -34.675 5.553   -19.936 0.010 42.88 ? 36   SER B C   1 
ATOM   2582 O O   . SER B 1 36  ? -35.379 4.716   -20.500 0.010 42.84 ? 36   SER B O   1 
ATOM   2583 C CB  . SER B 1 36  ? -35.850 7.568   -18.984 0.010 43.04 ? 36   SER B CB  1 
ATOM   2584 O OG  . SER B 1 36  ? -37.045 7.359   -19.715 0.010 43.02 ? 36   SER B OG  1 
ATOM   2585 N N   . ASN B 1 37  ? -33.467 5.893   -20.380 0.010 42.71 ? 37   ASN B N   1 
ATOM   2586 C CA  . ASN B 1 37  ? -32.920 5.310   -21.605 0.010 42.57 ? 37   ASN B CA  1 
ATOM   2587 C C   . ASN B 1 37  ? -32.043 4.081   -21.371 0.010 42.55 ? 37   ASN B C   1 
ATOM   2588 O O   . ASN B 1 37  ? -31.237 3.713   -22.226 0.010 42.52 ? 37   ASN B O   1 
ATOM   2589 C CB  . ASN B 1 37  ? -32.156 6.351   -22.428 0.010 42.54 ? 37   ASN B CB  1 
ATOM   2590 C CG  . ASN B 1 37  ? -30.790 6.663   -21.854 0.010 42.48 ? 37   ASN B CG  1 
ATOM   2591 O OD1 . ASN B 1 37  ? -30.666 7.057   -20.694 0.010 42.47 ? 37   ASN B OD1 1 
ATOM   2592 N ND2 . ASN B 1 37  ? -29.755 6.496   -22.670 0.010 42.44 ? 37   ASN B ND2 1 
ATOM   2593 N N   . GLN B 1 38  ? -32.198 3.456   -20.210 0.10  42.58 ? 38   GLN B N   1 
ATOM   2594 C CA  . GLN B 1 38  ? -31.551 2.176   -19.941 0.10  42.64 ? 38   GLN B CA  1 
ATOM   2595 C C   . GLN B 1 38  ? -30.116 2.295   -19.426 0.10  42.85 ? 38   GLN B C   1 
ATOM   2596 O O   . GLN B 1 38  ? -29.484 1.289   -19.107 0.10  42.78 ? 38   GLN B O   1 
ATOM   2597 C CB  . GLN B 1 38  ? -31.500 1.337   -21.220 0.10  42.54 ? 38   GLN B CB  1 
ATOM   2598 C CG  . GLN B 1 38  ? -32.713 1.526   -22.115 0.10  42.27 ? 38   GLN B CG  1 
ATOM   2599 C CD  . GLN B 1 38  ? -34.016 1.529   -21.339 0.10  41.87 ? 38   GLN B CD  1 
ATOM   2600 O OE1 . GLN B 1 38  ? -34.687 2.556   -21.237 0.10  41.73 ? 38   GLN B OE1 1 
ATOM   2601 N NE2 . GLN B 1 38  ? -34.377 0.380   -20.780 0.10  41.71 ? 38   GLN B NE2 1 
ATOM   2602 N N   . GLU B 1 39  ? -29.599 3.518   -19.354 0.40  43.19 ? 39   GLU B N   1 
ATOM   2603 C CA  . GLU B 1 39  ? -28.262 3.740   -18.815 0.40  43.72 ? 39   GLU B CA  1 
ATOM   2604 C C   . GLU B 1 39  ? -28.318 3.507   -17.313 0.40  44.30 ? 39   GLU B C   1 
ATOM   2605 O O   . GLU B 1 39  ? -29.273 3.922   -16.655 0.40  44.10 ? 39   GLU B O   1 
ATOM   2606 C CB  . GLU B 1 39  ? -27.798 5.171   -19.072 0.40  43.51 ? 39   GLU B CB  1 
ATOM   2607 C CG  . GLU B 1 39  ? -27.997 5.639   -20.490 0.40  43.21 ? 39   GLU B CG  1 
ATOM   2608 C CD  . GLU B 1 39  ? -27.118 6.815   -20.822 0.40  42.69 ? 39   GLU B CD  1 
ATOM   2609 O OE1 . GLU B 1 39  ? -26.596 7.444   -19.874 0.40  42.14 ? 39   GLU B OE1 1 
ATOM   2610 O OE2 . GLU B 1 39  ? -26.942 7.102   -22.026 0.40  42.76 ? 39   GLU B OE2 1 
ATOM   2611 N N   . THR B 1 40  ? -27.289 2.851   -16.777 1.00  45.26 ? 40   THR B N   1 
ATOM   2612 C CA  . THR B 1 40  ? -27.197 2.624   -15.335 1.00  46.23 ? 40   THR B CA  1 
ATOM   2613 C C   . THR B 1 40  ? -26.547 3.796   -14.604 1.00  46.65 ? 40   THR B C   1 
ATOM   2614 O O   . THR B 1 40  ? -25.596 4.417   -15.098 1.00  47.13 ? 40   THR B O   1 
ATOM   2615 C CB  . THR B 1 40  ? -26.444 1.323   -14.962 1.00  46.27 ? 40   THR B CB  1 
ATOM   2616 O OG1 . THR B 1 40  ? -26.998 0.203   -15.663 1.00  46.66 ? 40   THR B OG1 1 
ATOM   2617 C CG2 . THR B 1 40  ? -26.587 1.053   -13.455 1.00  47.02 ? 40   THR B CG2 1 
ATOM   2618 N N   . CYS B 1 41  ? -27.078 4.095   -13.426 1.00  46.86 ? 41   CYS B N   1 
ATOM   2619 C CA  . CYS B 1 41  ? -26.485 5.102   -12.565 1.00  47.35 ? 41   CYS B CA  1 
ATOM   2620 C C   . CYS B 1 41  ? -26.030 4.553   -11.231 1.00  46.55 ? 41   CYS B C   1 
ATOM   2621 O O   . CYS B 1 41  ? -26.664 3.675   -10.627 1.00  46.79 ? 41   CYS B O   1 
ATOM   2622 C CB  . CYS B 1 41  ? -27.435 6.268   -12.335 1.00  47.73 ? 41   CYS B CB  1 
ATOM   2623 S SG  . CYS B 1 41  ? -26.739 7.820   -12.953 1.00  52.41 ? 41   CYS B SG  1 
ATOM   2624 N N   . VAL B 1 42  ? -24.911 5.085   -10.775 1.00  45.50 ? 42   VAL B N   1 
ATOM   2625 C CA  . VAL B 1 42  ? -24.341 4.670   -9.518  1.00  44.46 ? 42   VAL B CA  1 
ATOM   2626 C C   . VAL B 1 42  ? -23.760 5.873   -8.819  1.00  43.57 ? 42   VAL B C   1 
ATOM   2627 O O   . VAL B 1 42  ? -23.286 6.819   -9.458  1.00  43.56 ? 42   VAL B O   1 
ATOM   2628 C CB  . VAL B 1 42  ? -23.258 3.594   -9.726  1.00  44.56 ? 42   VAL B CB  1 
ATOM   2629 C CG1 . VAL B 1 42  ? -22.166 3.679   -8.669  1.00  44.83 ? 42   VAL B CG1 1 
ATOM   2630 C CG2 . VAL B 1 42  ? -23.890 2.226   -9.698  1.00  45.41 ? 42   VAL B CG2 1 
ATOM   2631 N N   . THR B 1 43  ? -23.790 5.830   -7.495  0.40  42.41 ? 43   THR B N   1 
ATOM   2632 C CA  . THR B 1 43  ? -23.272 6.923   -6.711  0.40  41.44 ? 43   THR B CA  1 
ATOM   2633 C C   . THR B 1 43  ? -23.060 6.475   -5.281  0.40  40.23 ? 43   THR B C   1 
ATOM   2634 O O   . THR B 1 43  ? -24.010 6.169   -4.550  0.40  40.13 ? 43   THR B O   1 
ATOM   2635 C CB  . THR B 1 43  ? -24.189 8.160   -6.840  1.00  41.86 ? 43   THR B CB  1 
ATOM   2636 O OG1 . THR B 1 43  ? -23.965 8.761   -8.127  1.00  42.90 ? 43   THR B OG1 1 
ATOM   2637 C CG2 . THR B 1 43  ? -23.915 9.199   -5.755  1.00  42.08 ? 43   THR B CG2 1 
ATOM   2638 N N   . ILE B 1 44  ? -21.788 6.429   -4.905  1.00  38.73 ? 44   ILE B N   1 
ATOM   2639 C CA  . ILE B 1 44  ? -21.381 5.855   -3.635  1.00  37.56 ? 44   ILE B CA  1 
ATOM   2640 C C   . ILE B 1 44  ? -21.797 6.790   -2.527  1.00  36.83 ? 44   ILE B C   1 
ATOM   2641 O O   . ILE B 1 44  ? -21.280 7.901   -2.421  1.00  36.90 ? 44   ILE B O   1 
ATOM   2642 C CB  . ILE B 1 44  ? -19.856 5.592   -3.565  1.00  37.49 ? 44   ILE B CB  1 
ATOM   2643 C CG1 . ILE B 1 44  ? -19.360 4.876   -4.836  1.00  36.54 ? 44   ILE B CG1 1 
ATOM   2644 C CG2 . ILE B 1 44  ? -19.509 4.819   -2.292  1.00  36.69 ? 44   ILE B CG2 1 
ATOM   2645 C CD1 . ILE B 1 44  ? -19.923 3.480   -5.043  1.00  36.97 ? 44   ILE B CD1 1 
ATOM   2646 N N   . GLY B 1 45  ? -22.732 6.326   -1.707  1.00  35.94 ? 45   GLY B N   1 
ATOM   2647 C CA  . GLY B 1 45  ? -23.367 7.168   -0.709  1.00  34.92 ? 45   GLY B CA  1 
ATOM   2648 C C   . GLY B 1 45  ? -22.473 7.438   0.475   1.00  34.29 ? 45   GLY B C   1 
ATOM   2649 O O   . GLY B 1 45  ? -22.940 7.893   1.524   1.00  34.55 ? 45   GLY B O   1 
ATOM   2650 N N   . GLU B 1 46  ? -21.183 7.145   0.311   1.00  33.52 ? 46   GLU B N   1 
ATOM   2651 C CA  . GLU B 1 46  ? -20.211 7.287   1.393   1.00  32.25 ? 46   GLU B CA  1 
ATOM   2652 C C   . GLU B 1 46  ? -18.764 7.239   0.925   1.00  31.51 ? 46   GLU B C   1 
ATOM   2653 O O   . GLU B 1 46  ? -18.417 6.550   -0.046  1.00  31.30 ? 46   GLU B O   1 
ATOM   2654 C CB  . GLU B 1 46  ? -20.418 6.204   2.433   1.00  32.06 ? 46   GLU B CB  1 
ATOM   2655 C CG  . GLU B 1 46  ? -20.436 4.824   1.875   1.00  32.84 ? 46   GLU B CG  1 
ATOM   2656 C CD  . GLU B 1 46  ? -20.626 3.800   2.957   1.00  36.14 ? 46   GLU B CD  1 
ATOM   2657 O OE1 . GLU B 1 46  ? -19.629 3.482   3.649   1.00  36.81 ? 46   GLU B OE1 1 
ATOM   2658 O OE2 . GLU B 1 46  ? -21.774 3.319   3.125   1.00  37.47 ? 46   GLU B OE2 1 
ATOM   2659 N N   . SER B 1 47  ? -17.921 7.974   1.646   1.00  30.53 ? 47   SER B N   1 
ATOM   2660 C CA  . SER B 1 47  ? -16.482 7.912   1.460   1.00  29.69 ? 47   SER B CA  1 
ATOM   2661 C C   . SER B 1 47  ? -15.994 6.480   1.367   1.00  28.92 ? 47   SER B C   1 
ATOM   2662 O O   . SER B 1 47  ? -16.438 5.642   2.128   1.00  29.40 ? 47   SER B O   1 
ATOM   2663 C CB  . SER B 1 47  ? -15.784 8.603   2.617   1.00  29.17 ? 47   SER B CB  1 
ATOM   2664 O OG  . SER B 1 47  ? -14.515 9.069   2.193   1.00  30.49 ? 47   SER B OG  1 
ATOM   2665 N N   . VAL B 1 48  ? -15.112 6.203   0.410   1.00  28.22 ? 48   VAL B N   1 
ATOM   2666 C CA  . VAL B 1 48  ? -14.426 4.912   0.319   1.00  27.31 ? 48   VAL B CA  1 
ATOM   2667 C C   . VAL B 1 48  ? -12.930 5.162   0.275   1.00  26.92 ? 48   VAL B C   1 
ATOM   2668 O O   . VAL B 1 48  ? -12.126 4.240   0.136   1.00  26.98 ? 48   VAL B O   1 
ATOM   2669 C CB  . VAL B 1 48  ? -14.859 4.059   -0.909  1.00  27.35 ? 48   VAL B CB  1 
ATOM   2670 C CG1 . VAL B 1 48  ? -16.207 3.417   -0.634  1.00  28.10 ? 48   VAL B CG1 1 
ATOM   2671 C CG2 . VAL B 1 48  ? -14.895 4.881   -2.201  1.00  26.46 ? 48   VAL B CG2 1 
ATOM   2672 N N   . ARG B 1 49  ? -12.574 6.438   0.391   1.00  26.36 ? 49   ARG B N   1 
ATOM   2673 C CA  . ARG B 1 49  ? -11.187 6.886   0.433   1.00  25.52 ? 49   ARG B CA  1 
ATOM   2674 C C   . ARG B 1 49  ? -10.295 6.039   1.355   1.00  25.32 ? 49   ARG B C   1 
ATOM   2675 O O   . ARG B 1 49  ? -10.462 6.001   2.589   1.00  24.70 ? 49   ARG B O   1 
ATOM   2676 C CB  . ARG B 1 49  ? -11.157 8.348   0.844   1.00  25.39 ? 49   ARG B CB  1 
ATOM   2677 C CG  . ARG B 1 49  ? -9.871  9.018   0.574   1.00  25.58 ? 49   ARG B CG  1 
ATOM   2678 C CD  . ARG B 1 49  ? -10.006 10.477  0.837   1.00  27.00 ? 49   ARG B CD  1 
ATOM   2679 N NE  . ARG B 1 49  ? -10.827 11.154  -0.162  1.00  27.83 ? 49   ARG B NE  1 
ATOM   2680 C CZ  . ARG B 1 49  ? -10.341 11.695  -1.268  1.00  30.39 ? 49   ARG B CZ  1 
ATOM   2681 N NH1 . ARG B 1 49  ? -9.038  11.626  -1.542  1.00  31.38 ? 49   ARG B NH1 1 
ATOM   2682 N NH2 . ARG B 1 49  ? -11.157 12.296  -2.115  1.00  34.07 ? 49   ARG B NH2 1 
ATOM   2683 N N   . GLY B 1 50  ? -9.358  5.341   0.719   1.00  25.34 ? 50   GLY B N   1 
ATOM   2684 C CA  . GLY B 1 50  ? -8.355  4.548   1.439   1.00  25.11 ? 50   GLY B CA  1 
ATOM   2685 C C   . GLY B 1 50  ? -8.932  3.322   2.104   1.00  24.86 ? 50   GLY B C   1 
ATOM   2686 O O   . GLY B 1 50  ? -8.361  2.814   3.056   1.00  25.64 ? 50   GLY B O   1 
ATOM   2687 N N   . GLU B 1 51  ? -10.068 2.844   1.606   0.40  24.36 ? 51   GLU B N   1 
ATOM   2688 C CA  . GLU B 1 51  ? -10.676 1.644   2.138   0.40  23.64 ? 51   GLU B CA  1 
ATOM   2689 C C   . GLU B 1 51  ? -10.402 0.477   1.210   0.40  23.27 ? 51   GLU B C   1 
ATOM   2690 O O   . GLU B 1 51  ? -10.086 0.661   0.044   0.40  22.86 ? 51   GLU B O   1 
ATOM   2691 C CB  . GLU B 1 51  ? -12.184 1.821   2.300   0.40  23.77 ? 51   GLU B CB  1 
ATOM   2692 C CG  . GLU B 1 51  ? -12.616 3.153   2.869   0.40  23.65 ? 51   GLU B CG  1 
ATOM   2693 C CD  . GLU B 1 51  ? -12.682 3.170   4.365   0.40  23.28 ? 51   GLU B CD  1 
ATOM   2694 O OE1 . GLU B 1 51  ? -11.633 2.977   5.005   0.40  24.55 ? 51   GLU B OE1 1 
ATOM   2695 O OE2 . GLU B 1 51  ? -13.783 3.403   4.899   0.40  22.45 ? 51   GLU B OE2 1 
ATOM   2696 N N   . ASP B 1 52  ? -10.526 -0.720  1.771   1.00  23.16 ? 52   ASP B N   1 
ATOM   2697 C CA  . ASP B 1 52  ? -10.408 -1.988  1.090   1.00  22.90 ? 52   ASP B CA  1 
ATOM   2698 C C   . ASP B 1 52  ? -11.825 -2.443  0.690   1.00  22.42 ? 52   ASP B C   1 
ATOM   2699 O O   . ASP B 1 52  ? -12.519 -3.111  1.446   1.00  21.78 ? 52   ASP B O   1 
ATOM   2700 C CB  . ASP B 1 52  ? -9.669  -2.964  2.026   1.00  22.89 ? 52   ASP B CB  1 
ATOM   2701 C CG  . ASP B 1 52  ? -9.545  -4.377  1.456   1.00  25.53 ? 52   ASP B CG  1 
ATOM   2702 O OD1 . ASP B 1 52  ? -9.338  -4.563  0.219   1.00  26.72 ? 52   ASP B OD1 1 
ATOM   2703 O OD2 . ASP B 1 52  ? -9.642  -5.320  2.286   1.00  27.02 ? 52   ASP B OD2 1 
ATOM   2704 N N   . VAL B 1 53  ? -12.234 -2.047  -0.522  1.00  22.79 ? 53   VAL B N   1 
ATOM   2705 C CA  . VAL B 1 53  ? -13.608 -2.192  -1.026  1.00  22.72 ? 53   VAL B CA  1 
ATOM   2706 C C   . VAL B 1 53  ? -13.825 -3.506  -1.758  1.00  22.67 ? 53   VAL B C   1 
ATOM   2707 O O   . VAL B 1 53  ? -12.961 -3.934  -2.519  1.00  23.74 ? 53   VAL B O   1 
ATOM   2708 C CB  . VAL B 1 53  ? -13.966 -1.033  -1.971  1.00  22.79 ? 53   VAL B CB  1 
ATOM   2709 C CG1 . VAL B 1 53  ? -15.381 -1.277  -2.629  1.00  22.87 ? 53   VAL B CG1 1 
ATOM   2710 C CG2 . VAL B 1 53  ? -13.922 0.336   -1.187  1.00  22.95 ? 53   VAL B CG2 1 
ATOM   2711 N N   . TYR B 1 54  ? -14.974 -4.133  -1.516  1.00  22.11 ? 54   TYR B N   1 
ATOM   2712 C CA  . TYR B 1 54  ? -15.433 -5.316  -2.242  1.00  21.78 ? 54   TYR B CA  1 
ATOM   2713 C C   . TYR B 1 54  ? -16.793 -5.067  -2.909  1.00  22.15 ? 54   TYR B C   1 
ATOM   2714 O O   . TYR B 1 54  ? -17.782 -4.714  -2.233  1.00  21.53 ? 54   TYR B O   1 
ATOM   2715 C CB  . TYR B 1 54  ? -15.529 -6.501  -1.274  1.00  21.29 ? 54   TYR B CB  1 
ATOM   2716 C CG  . TYR B 1 54  ? -14.190 -6.826  -0.691  1.00  21.24 ? 54   TYR B CG  1 
ATOM   2717 C CD1 . TYR B 1 54  ? -13.612 -5.999  0.281   1.00  21.19 ? 54   TYR B CD1 1 
ATOM   2718 C CD2 . TYR B 1 54  ? -13.455 -7.932  -1.142  1.00  20.97 ? 54   TYR B CD2 1 
ATOM   2719 C CE1 . TYR B 1 54  ? -12.362 -6.272  0.798   1.00  19.72 ? 54   TYR B CE1 1 
ATOM   2720 C CE2 . TYR B 1 54  ? -12.202 -8.201  -0.633  1.00  19.58 ? 54   TYR B CE2 1 
ATOM   2721 C CZ  . TYR B 1 54  ? -11.673 -7.369  0.342   1.00  19.65 ? 54   TYR B CZ  1 
ATOM   2722 O OH  . TYR B 1 54  ? -10.444 -7.625  0.872   1.00  22.32 ? 54   TYR B OH  1 
ATOM   2723 N N   . ILE B 1 55  ? -16.861 -5.259  -4.232  1.00  22.66 ? 55   ILE B N   1 
ATOM   2724 C CA  . ILE B 1 55  ? -18.169 -5.181  -4.912  1.00  23.58 ? 55   ILE B CA  1 
ATOM   2725 C C   . ILE B 1 55  ? -18.678 -6.546  -5.332  1.00  24.40 ? 55   ILE B C   1 
ATOM   2726 O O   . ILE B 1 55  ? -18.037 -7.225  -6.127  1.00  24.98 ? 55   ILE B O   1 
ATOM   2727 C CB  . ILE B 1 55  ? -18.155 -4.274  -6.126  1.00  22.82 ? 55   ILE B CB  1 
ATOM   2728 C CG1 . ILE B 1 55  ? -17.726 -2.867  -5.747  1.00  22.74 ? 55   ILE B CG1 1 
ATOM   2729 C CG2 . ILE B 1 55  ? -19.543 -4.201  -6.700  1.00  23.39 ? 55   ILE B CG2 1 
ATOM   2730 C CD1 . ILE B 1 55  ? -16.947 -2.196  -6.838  1.00  21.97 ? 55   ILE B CD1 1 
ATOM   2731 N N   . VAL B 1 56  ? -19.822 -6.945  -4.780  1.00  25.68 ? 56   VAL B N   1 
ATOM   2732 C CA  . VAL B 1 56  ? -20.373 -8.288  -4.993  1.00  27.17 ? 56   VAL B CA  1 
ATOM   2733 C C   . VAL B 1 56  ? -21.294 -8.261  -6.205  1.00  28.48 ? 56   VAL B C   1 
ATOM   2734 O O   . VAL B 1 56  ? -22.128 -7.369  -6.315  1.00  29.32 ? 56   VAL B O   1 
ATOM   2735 C CB  . VAL B 1 56  ? -21.133 -8.801  -3.731  1.00  26.64 ? 56   VAL B CB  1 
ATOM   2736 C CG1 . VAL B 1 56  ? -21.335 -10.297 -3.780  1.00  26.15 ? 56   VAL B CG1 1 
ATOM   2737 C CG2 . VAL B 1 56  ? -20.372 -8.444  -2.480  1.00  26.48 ? 56   VAL B CG2 1 
ATOM   2738 N N   . GLN B 1 57  ? -21.141 -9.213  -7.119  0.10  30.28 ? 57   GLN B N   1 
ATOM   2739 C CA  . GLN B 1 57  ? -21.899 -9.180  -8.369  0.10  32.03 ? 57   GLN B CA  1 
ATOM   2740 C C   . GLN B 1 57  ? -23.326 -9.656  -8.153  0.10  33.36 ? 57   GLN B C   1 
ATOM   2741 O O   . GLN B 1 57  ? -23.559 -10.732 -7.601  0.10  33.39 ? 57   GLN B O   1 
ATOM   2742 C CB  . GLN B 1 57  ? -21.209 -10.006 -9.456  0.10  32.02 ? 57   GLN B CB  1 
ATOM   2743 C CG  . GLN B 1 57  ? -21.981 -11.232 -9.920  0.10  31.90 ? 57   GLN B CG  1 
ATOM   2744 C CD  . GLN B 1 57  ? -22.520 -11.081 -11.332 0.10  31.45 ? 57   GLN B CD  1 
ATOM   2745 O OE1 . GLN B 1 57  ? -23.461 -11.769 -11.728 0.10  31.26 ? 57   GLN B OE1 1 
ATOM   2746 N NE2 . GLN B 1 57  ? -21.918 -10.182 -12.101 0.10  31.41 ? 57   GLN B NE2 1 
ATOM   2747 N N   . SER B 1 58  ? -24.272 -8.832  -8.591  1.00  35.30 ? 58   SER B N   1 
ATOM   2748 C CA  . SER B 1 58  ? -25.720 -9.099  -8.446  1.00  36.82 ? 58   SER B CA  1 
ATOM   2749 C C   . SER B 1 58  ? -26.277 -10.239 -9.339  1.00  36.97 ? 58   SER B C   1 
ATOM   2750 O O   . SER B 1 58  ? -25.802 -10.464 -10.463 1.00  37.33 ? 58   SER B O   1 
ATOM   2751 C CB  . SER B 1 58  ? -26.501 -7.806  -8.724  1.00  36.90 ? 58   SER B CB  1 
ATOM   2752 O OG  . SER B 1 58  ? -27.788 -8.085  -9.263  1.00  39.26 ? 58   SER B OG  1 
ATOM   2753 N N   . GLY B 1 59  ? -27.315 -10.914 -8.856  0.010 37.01 ? 59   GLY B N   1 
ATOM   2754 C CA  . GLY B 1 59  ? -27.933 -11.999 -9.614  0.010 36.96 ? 59   GLY B CA  1 
ATOM   2755 C C   . GLY B 1 59  ? -29.218 -11.617 -10.326 0.010 36.92 ? 59   GLY B C   1 
ATOM   2756 O O   . GLY B 1 59  ? -30.053 -12.474 -10.612 0.010 36.93 ? 59   GLY B O   1 
ATOM   2757 N N   . CYS B 1 60  ? -29.377 -10.331 -10.622 0.10  36.82 ? 60   CYS B N   1 
ATOM   2758 C CA  . CYS B 1 60  ? -30.597 -9.841  -11.261 0.10  36.70 ? 60   CYS B CA  1 
ATOM   2759 C C   . CYS B 1 60  ? -31.050 -10.739 -12.413 0.10  36.49 ? 60   CYS B C   1 
ATOM   2760 O O   . CYS B 1 60  ? -32.207 -11.158 -12.465 0.10  36.54 ? 60   CYS B O   1 
ATOM   2761 C CB  . CYS B 1 60  ? -30.409 -8.403  -11.752 0.10  36.72 ? 60   CYS B CB  1 
ATOM   2762 S SG  . CYS B 1 60  ? -31.919 -7.612  -12.359 0.10  36.96 ? 60   CYS B SG  1 
ATOM   2763 N N   . GLY B 1 61  ? -30.135 -11.029 -13.332 0.010 36.19 ? 61   GLY B N   1 
ATOM   2764 C CA  . GLY B 1 61  ? -30.444 -11.863 -14.489 0.010 35.73 ? 61   GLY B CA  1 
ATOM   2765 C C   . GLY B 1 61  ? -29.887 -11.286 -15.776 0.010 35.36 ? 61   GLY B C   1 
ATOM   2766 O O   . GLY B 1 61  ? -29.166 -11.963 -16.509 0.010 35.37 ? 61   GLY B O   1 
ATOM   2767 N N   . GLU B 1 62  ? -30.219 -10.027 -16.046 0.50  34.91 ? 62   GLU B N   1 
ATOM   2768 C CA  . GLU B 1 62  ? -29.749 -9.347  -17.252 0.50  34.40 ? 62   GLU B CA  1 
ATOM   2769 C C   . GLU B 1 62  ? -28.258 -9.060  -17.179 0.50  34.05 ? 62   GLU B C   1 
ATOM   2770 O O   . GLU B 1 62  ? -27.820 -8.068  -16.593 0.50  33.97 ? 62   GLU B O   1 
ATOM   2771 C CB  . GLU B 1 62  ? -30.529 -8.060  -17.492 0.50  34.47 ? 62   GLU B CB  1 
ATOM   2772 C CG  . GLU B 1 62  ? -30.803 -7.782  -18.964 0.50  34.49 ? 62   GLU B CG  1 
ATOM   2773 C CD  . GLU B 1 62  ? -29.620 -7.160  -19.680 0.50  34.95 ? 62   GLU B CD  1 
ATOM   2774 O OE1 . GLU B 1 62  ? -28.489 -7.253  -19.155 0.50  36.30 ? 62   GLU B OE1 1 
ATOM   2775 O OE2 . GLU B 1 62  ? -29.814 -6.564  -20.768 0.50  34.69 ? 62   GLU B OE2 1 
ATOM   2776 N N   . ILE B 1 63  ? -27.497 -9.940  -17.813 1.00  33.81 ? 63   ILE B N   1 
ATOM   2777 C CA  . ILE B 1 63  ? -26.026 -9.985  -17.736 1.00  33.48 ? 63   ILE B CA  1 
ATOM   2778 C C   . ILE B 1 63  ? -25.291 -8.706  -18.186 1.00  32.99 ? 63   ILE B C   1 
ATOM   2779 O O   . ILE B 1 63  ? -24.324 -8.297  -17.543 1.00  33.09 ? 63   ILE B O   1 
ATOM   2780 C CB  . ILE B 1 63  ? -25.451 -11.254 -18.470 1.00  33.31 ? 63   ILE B CB  1 
ATOM   2781 C CG1 . ILE B 1 63  ? -23.937 -11.342 -18.322 1.00  33.44 ? 63   ILE B CG1 1 
ATOM   2782 C CG2 . ILE B 1 63  ? -25.800 -11.248 -19.949 1.00  32.24 ? 63   ILE B CG2 1 
ATOM   2783 C CD1 . ILE B 1 63  ? -23.362 -12.630 -18.868 1.00  34.80 ? 63   ILE B CD1 1 
ATOM   2784 N N   . ASN B 1 64  ? -25.748 -8.063  -19.254 1.00  32.31 ? 64   ASN B N   1 
ATOM   2785 C CA  . ASN B 1 64  ? -25.058 -6.854  -19.730 1.00  31.62 ? 64   ASN B CA  1 
ATOM   2786 C C   . ASN B 1 64  ? -25.314 -5.660  -18.852 1.00  31.76 ? 64   ASN B C   1 
ATOM   2787 O O   . ASN B 1 64  ? -24.365 -4.946  -18.520 1.00  31.54 ? 64   ASN B O   1 
ATOM   2788 C CB  . ASN B 1 64  ? -25.351 -6.556  -21.200 1.00  31.16 ? 64   ASN B CB  1 
ATOM   2789 C CG  . ASN B 1 64  ? -25.010 -7.726  -22.088 1.00  29.10 ? 64   ASN B CG  1 
ATOM   2790 O OD1 . ASN B 1 64  ? -25.746 -8.049  -23.024 1.00  28.08 ? 64   ASN B OD1 1 
ATOM   2791 N ND2 . ASN B 1 64  ? -23.913 -8.407  -21.766 1.00  24.00 ? 64   ASN B ND2 1 
ATOM   2792 N N   . ASP B 1 65  ? -26.579 -5.462  -18.463 1.00  32.10 ? 65   ASP B N   1 
ATOM   2793 C CA  . ASP B 1 65  ? -26.936 -4.568  -17.336 1.00  32.39 ? 65   ASP B CA  1 
ATOM   2794 C C   . ASP B 1 65  ? -26.046 -4.808  -16.110 1.00  31.97 ? 65   ASP B C   1 
ATOM   2795 O O   . ASP B 1 65  ? -25.335 -3.908  -15.658 1.00  31.13 ? 65   ASP B O   1 
ATOM   2796 C CB  . ASP B 1 65  ? -28.386 -4.783  -16.923 1.00  32.70 ? 65   ASP B CB  1 
ATOM   2797 C CG  . ASP B 1 65  ? -29.370 -4.343  -17.982 1.00  35.33 ? 65   ASP B CG  1 
ATOM   2798 O OD1 . ASP B 1 65  ? -28.950 -3.690  -18.973 1.00  37.61 ? 65   ASP B OD1 1 
ATOM   2799 O OD2 . ASP B 1 65  ? -30.578 -4.653  -17.818 1.00  37.81 ? 65   ASP B OD2 1 
ATOM   2800 N N   . ASN B 1 66  ? -26.084 -6.046  -15.609 1.00  31.79 ? 66   ASN B N   1 
ATOM   2801 C CA  . ASN B 1 66  ? -25.313 -6.443  -14.449 1.00  31.56 ? 66   ASN B CA  1 
ATOM   2802 C C   . ASN B 1 66  ? -23.841 -6.177  -14.587 1.00  30.94 ? 66   ASN B C   1 
ATOM   2803 O O   . ASN B 1 66  ? -23.241 -5.637  -13.661 1.00  31.20 ? 66   ASN B O   1 
ATOM   2804 C CB  . ASN B 1 66  ? -25.578 -7.898  -14.106 1.00  32.00 ? 66   ASN B CB  1 
ATOM   2805 C CG  . ASN B 1 66  ? -26.932 -8.089  -13.444 1.00  33.67 ? 66   ASN B CG  1 
ATOM   2806 O OD1 . ASN B 1 66  ? -27.247 -7.439  -12.436 1.00  35.89 ? 66   ASN B OD1 1 
ATOM   2807 N ND2 . ASN B 1 66  ? -27.740 -8.980  -14.003 1.00  34.73 ? 66   ASN B ND2 1 
ATOM   2808 N N   . LEU B 1 67  ? -23.269 -6.515  -15.743 1.00  30.29 ? 67   LEU B N   1 
ATOM   2809 C CA  . LEU B 1 67  ? -21.860 -6.233  -15.995 1.00  29.59 ? 67   LEU B CA  1 
ATOM   2810 C C   . LEU B 1 67  ? -21.530 -4.747  -16.002 1.00  29.38 ? 67   LEU B C   1 
ATOM   2811 O O   . LEU B 1 67  ? -20.580 -4.343  -15.351 1.00  29.53 ? 67   LEU B O   1 
ATOM   2812 C CB  . LEU B 1 67  ? -21.365 -6.874  -17.285 1.00  29.57 ? 67   LEU B CB  1 
ATOM   2813 C CG  . LEU B 1 67  ? -19.852 -6.767  -17.554 1.00  29.22 ? 67   LEU B CG  1 
ATOM   2814 C CD1 . LEU B 1 67  ? -19.005 -7.205  -16.333 1.00  29.54 ? 67   LEU B CD1 1 
ATOM   2815 C CD2 . LEU B 1 67  ? -19.473 -7.584  -18.771 1.00  27.31 ? 67   LEU B CD2 1 
ATOM   2816 N N   . MET B 1 68  ? -22.303 -3.935  -16.721 0.10  28.92 ? 68   MET B N   1 
ATOM   2817 C CA  . MET B 1 68  ? -22.035 -2.494  -16.765 0.10  28.39 ? 68   MET B CA  1 
ATOM   2818 C C   . MET B 1 68  ? -21.997 -1.885  -15.364 0.10  28.22 ? 68   MET B C   1 
ATOM   2819 O O   . MET B 1 68  ? -21.082 -1.138  -15.026 0.10  28.10 ? 68   MET B O   1 
ATOM   2820 C CB  . MET B 1 68  ? -23.051 -1.772  -17.649 0.10  28.27 ? 68   MET B CB  1 
ATOM   2821 C CG  . MET B 1 68  ? -22.777 -1.925  -19.134 0.10  27.59 ? 68   MET B CG  1 
ATOM   2822 S SD  . MET B 1 68  ? -21.059 -1.568  -19.540 0.10  25.91 ? 68   MET B SD  1 
ATOM   2823 C CE  . MET B 1 68  ? -20.880 0.069   -18.836 0.10  25.77 ? 68   MET B CE  1 
ATOM   2824 N N   . GLU B 1 69  ? -22.987 -2.252  -14.558 1.00  28.07 ? 69   GLU B N   1 
ATOM   2825 C CA  . GLU B 1 69  ? -23.149 -1.807  -13.174 1.00  27.85 ? 69   GLU B CA  1 
ATOM   2826 C C   . GLU B 1 69  ? -21.928 -2.120  -12.305 1.00  27.20 ? 69   GLU B C   1 
ATOM   2827 O O   . GLU B 1 69  ? -21.418 -1.249  -11.594 1.00  27.17 ? 69   GLU B O   1 
ATOM   2828 C CB  . GLU B 1 69  ? -24.396 -2.447  -12.579 1.00  27.91 ? 69   GLU B CB  1 
ATOM   2829 C CG  . GLU B 1 69  ? -24.865 -1.796  -11.292 1.00  31.84 ? 69   GLU B CG  1 
ATOM   2830 C CD  . GLU B 1 69  ? -26.259 -2.266  -10.880 1.00  35.57 ? 69   GLU B CD  1 
ATOM   2831 O OE1 . GLU B 1 69  ? -26.419 -3.484  -10.608 1.00  39.15 ? 69   GLU B OE1 1 
ATOM   2832 O OE2 . GLU B 1 69  ? -27.199 -1.417  -10.839 1.00  34.93 ? 69   GLU B OE2 1 
ATOM   2833 N N   . LEU B 1 70  ? -21.462 -3.367  -12.372 1.00  26.34 ? 70   LEU B N   1 
ATOM   2834 C CA  . LEU B 1 70  ? -20.215 -3.780  -11.731 1.00  25.16 ? 70   LEU B CA  1 
ATOM   2835 C C   . LEU B 1 70  ? -19.024 -2.915  -12.141 1.00  25.26 ? 70   LEU B C   1 
ATOM   2836 O O   . LEU B 1 70  ? -18.317 -2.389  -11.292 1.00  25.85 ? 70   LEU B O   1 
ATOM   2837 C CB  . LEU B 1 70  ? -19.920 -5.219  -12.085 1.00  24.44 ? 70   LEU B CB  1 
ATOM   2838 C CG  . LEU B 1 70  ? -18.768 -5.922  -11.396 1.00  22.81 ? 70   LEU B CG  1 
ATOM   2839 C CD1 . LEU B 1 70  ? -18.709 -5.635  -9.908  1.00  19.79 ? 70   LEU B CD1 1 
ATOM   2840 C CD2 . LEU B 1 70  ? -19.010 -7.388  -11.634 1.00  22.54 ? 70   LEU B CD2 1 
ATOM   2841 N N   . LEU B 1 71  ? -18.797 -2.781  -13.438 1.00  24.94 ? 71   LEU B N   1 
ATOM   2842 C CA  . LEU B 1 71  ? -17.753 -1.921  -13.943 1.00  24.42 ? 71   LEU B CA  1 
ATOM   2843 C C   . LEU B 1 71  ? -17.890 -0.499  -13.417 1.00  24.81 ? 71   LEU B C   1 
ATOM   2844 O O   . LEU B 1 71  ? -16.886 0.141   -13.069 1.00  24.54 ? 71   LEU B O   1 
ATOM   2845 C CB  . LEU B 1 71  ? -17.792 -1.901  -15.467 1.00  23.90 ? 71   LEU B CB  1 
ATOM   2846 C CG  . LEU B 1 71  ? -17.540 -3.215  -16.172 1.00  22.36 ? 71   LEU B CG  1 
ATOM   2847 C CD1 . LEU B 1 71  ? -17.651 -2.958  -17.655 1.00  22.06 ? 71   LEU B CD1 1 
ATOM   2848 C CD2 . LEU B 1 71  ? -16.179 -3.824  -15.806 1.00  21.34 ? 71   LEU B CD2 1 
ATOM   2849 N N   . ILE B 1 72  ? -19.131 -0.007  -13.368 1.00  25.68 ? 72   ILE B N   1 
ATOM   2850 C CA  . ILE B 1 72  ? -19.387 1.396   -13.021 1.00  26.37 ? 72   ILE B CA  1 
ATOM   2851 C C   . ILE B 1 72  ? -19.031 1.654   -11.570 1.00  26.65 ? 72   ILE B C   1 
ATOM   2852 O O   . ILE B 1 72  ? -18.306 2.600   -11.278 1.00  27.44 ? 72   ILE B O   1 
ATOM   2853 C CB  . ILE B 1 72  ? -20.843 1.821   -13.331 1.00  26.49 ? 72   ILE B CB  1 
ATOM   2854 C CG1 . ILE B 1 72  ? -21.066 1.896   -14.844 1.00  25.76 ? 72   ILE B CG1 1 
ATOM   2855 C CG2 . ILE B 1 72  ? -21.148 3.160   -12.716 1.00  26.75 ? 72   ILE B CG2 1 
ATOM   2856 C CD1 . ILE B 1 72  ? -22.524 1.849   -15.239 1.00  25.17 ? 72   ILE B CD1 1 
ATOM   2857 N N   . MET B 1 73  ? -19.497 0.778   -10.685 0.97  26.85 ? 73   MET B N   1 
ATOM   2858 C CA  . MET B 1 73  ? -19.133 0.818   -9.264  0.97  27.27 ? 73   MET B CA  1 
ATOM   2859 C C   . MET B 1 73  ? -17.640 0.669   -9.020  0.97  27.09 ? 73   MET B C   1 
ATOM   2860 O O   . MET B 1 73  ? -17.074 1.350   -8.165  0.97  27.65 ? 73   MET B O   1 
ATOM   2861 C CB  . MET B 1 73  ? -19.867 -0.265  -8.492  0.97  27.33 ? 73   MET B CB  1 
ATOM   2862 C CG  . MET B 1 73  ? -21.350 -0.088  -8.506  0.97  29.96 ? 73   MET B CG  1 
ATOM   2863 S SD  . MET B 1 73  ? -22.083 -0.902  -7.084  0.97  36.37 ? 73   MET B SD  1 
ATOM   2864 C CE  . MET B 1 73  ? -21.533 0.233   -5.785  0.97  35.08 ? 73   MET B CE  1 
ATOM   2865 N N   . ILE B 1 74  ? -16.999 -0.232  -9.757  1.00  27.05 ? 74   ILE B N   1 
ATOM   2866 C CA  . ILE B 1 74  ? -15.539 -0.331  -9.703  1.00  27.22 ? 74   ILE B CA  1 
ATOM   2867 C C   . ILE B 1 74  ? -14.896 1.023   -10.054 1.00  27.16 ? 74   ILE B C   1 
ATOM   2868 O O   . ILE B 1 74  ? -14.062 1.543   -9.289  1.00  26.63 ? 74   ILE B O   1 
ATOM   2869 C CB  . ILE B 1 74  ? -15.025 -1.439  -10.644 1.00  27.14 ? 74   ILE B CB  1 
ATOM   2870 C CG1 . ILE B 1 74  ? -15.555 -2.810  -10.173 1.00  27.54 ? 74   ILE B CG1 1 
ATOM   2871 C CG2 . ILE B 1 74  ? -13.498 -1.398  -10.741 1.00  27.09 ? 74   ILE B CG2 1 
ATOM   2872 C CD1 . ILE B 1 74  ? -15.073 -4.020  -10.999 1.00  27.25 ? 74   ILE B CD1 1 
ATOM   2873 N N   . ASN B 1 75  ? -15.311 1.593   -11.191 1.00  27.05 ? 75   ASN B N   1 
ATOM   2874 C CA  . ASN B 1 75  ? -14.780 2.871   -11.636 1.00  27.50 ? 75   ASN B CA  1 
ATOM   2875 C C   . ASN B 1 75  ? -15.080 3.997   -10.658 1.00  27.24 ? 75   ASN B C   1 
ATOM   2876 O O   . ASN B 1 75  ? -14.242 4.878   -10.432 1.00  27.31 ? 75   ASN B O   1 
ATOM   2877 C CB  . ASN B 1 75  ? -15.339 3.264   -12.987 1.00  28.37 ? 75   ASN B CB  1 
ATOM   2878 C CG  . ASN B 1 75  ? -14.752 4.577   -13.483 1.00  30.49 ? 75   ASN B CG  1 
ATOM   2879 O OD1 . ASN B 1 75  ? -13.524 4.673   -13.649 1.00  33.83 ? 75   ASN B OD1 1 
ATOM   2880 N ND2 . ASN B 1 75  ? -15.615 5.600   -13.687 1.00  31.50 ? 75   ASN B ND2 1 
ATOM   2881 N N   . ALA B 1 76  ? -16.286 3.946   -10.093 1.00  26.54 ? 76   ALA B N   1 
ATOM   2882 C CA  . ALA B 1 76  ? -16.767 4.906   -9.123  1.00  26.31 ? 76   ALA B CA  1 
ATOM   2883 C C   . ALA B 1 76  ? -15.889 4.938   -7.899  1.00  26.31 ? 76   ALA B C   1 
ATOM   2884 O O   . ALA B 1 76  ? -15.524 6.009   -7.419  1.00  26.31 ? 76   ALA B O   1 
ATOM   2885 C CB  . ALA B 1 76  ? -18.198 4.562   -8.733  1.00  26.23 ? 76   ALA B CB  1 
ATOM   2886 N N   . CYS B 1 77  ? -15.563 3.751   -7.397  1.00  26.62 ? 77   CYS B N   1 
ATOM   2887 C CA  . CYS B 1 77  ? -14.723 3.610   -6.218  1.00  26.87 ? 77   CYS B CA  1 
ATOM   2888 C C   . CYS B 1 77  ? -13.265 3.943   -6.430  1.00  26.75 ? 77   CYS B C   1 
ATOM   2889 O O   . CYS B 1 77  ? -12.624 4.429   -5.513  1.00  27.07 ? 77   CYS B O   1 
ATOM   2890 C CB  . CYS B 1 77  ? -14.832 2.210   -5.640  1.00  27.02 ? 77   CYS B CB  1 
ATOM   2891 S SG  . CYS B 1 77  ? -16.509 1.858   -5.154  1.00  28.32 ? 77   CYS B SG  1 
ATOM   2892 N N   . LYS B 1 78  ? -12.735 3.677   -7.627  1.00  26.87 ? 78   LYS B N   1 
ATOM   2893 C CA  . LYS B 1 78  ? -11.303 3.881   -7.888  1.00  26.57 ? 78   LYS B CA  1 
ATOM   2894 C C   . LYS B 1 78  ? -10.956 5.350   -7.910  1.00  26.25 ? 78   LYS B C   1 
ATOM   2895 O O   . LYS B 1 78  ? -9.932  5.761   -7.387  1.00  25.93 ? 78   LYS B O   1 
ATOM   2896 C CB  . LYS B 1 78  ? -10.883 3.250   -9.218  1.00  26.55 ? 78   LYS B CB  1 
ATOM   2897 C CG  . LYS B 1 78  ? -10.179 1.922   -9.092  1.00  27.25 ? 78   LYS B CG  1 
ATOM   2898 C CD  . LYS B 1 78  ? -8.650  2.074   -9.106  1.00  28.25 ? 78   LYS B CD  1 
ATOM   2899 C CE  . LYS B 1 78  ? -7.955  0.878   -8.411  1.00  27.72 ? 78   LYS B CE  1 
ATOM   2900 N NZ  . LYS B 1 78  ? -8.190  0.902   -6.888  1.00  28.01 ? 78   LYS B NZ  1 
ATOM   2901 N N   . ILE B 1 79  ? -11.815 6.145   -8.530  1.00  26.20 ? 79   ILE B N   1 
ATOM   2902 C CA  . ILE B 1 79  ? -11.510 7.549   -8.686  1.00  26.12 ? 79   ILE B CA  1 
ATOM   2903 C C   . ILE B 1 79  ? -11.857 8.244   -7.375  1.00  26.39 ? 79   ILE B C   1 
ATOM   2904 O O   . ILE B 1 79  ? -11.415 9.361   -7.088  1.00  26.68 ? 79   ILE B O   1 
ATOM   2905 C CB  . ILE B 1 79  ? -12.190 8.159   -9.936  1.00  25.98 ? 79   ILE B CB  1 
ATOM   2906 C CG1 . ILE B 1 79  ? -13.718 8.156   -9.785  1.00  25.77 ? 79   ILE B CG1 1 
ATOM   2907 C CG2 . ILE B 1 79  ? -11.710 7.400   -11.192 1.00  25.11 ? 79   ILE B CG2 1 
ATOM   2908 C CD1 . ILE B 1 79  ? -14.488 8.677   -11.007 1.00  26.41 ? 79   ILE B CD1 1 
ATOM   2909 N N   . ALA B 1 80  ? -12.618 7.538   -6.550  1.00  26.36 ? 80   ALA B N   1 
ATOM   2910 C CA  . ALA B 1 80  ? -12.877 7.970   -5.189  1.00  26.43 ? 80   ALA B CA  1 
ATOM   2911 C C   . ALA B 1 80  ? -11.763 7.565   -4.193  1.00  26.52 ? 80   ALA B C   1 
ATOM   2912 O O   . ALA B 1 80  ? -11.953 7.671   -2.984  1.00  26.92 ? 80   ALA B O   1 
ATOM   2913 C CB  . ALA B 1 80  ? -14.255 7.481   -4.722  1.00  25.92 ? 80   ALA B CB  1 
ATOM   2914 N N   . SER B 1 81  ? -10.614 7.117   -4.701  1.00  26.40 ? 81   SER B N   1 
ATOM   2915 C CA  . SER B 1 81  ? -9.410  6.879   -3.898  1.00  26.61 ? 81   SER B CA  1 
ATOM   2916 C C   . SER B 1 81  ? -9.476  5.690   -2.938  1.00  26.79 ? 81   SER B C   1 
ATOM   2917 O O   . SER B 1 81  ? -8.681  5.608   -1.954  1.00  26.77 ? 81   SER B O   1 
ATOM   2918 C CB  . SER B 1 81  ? -8.980  8.133   -3.138  1.00  26.71 ? 81   SER B CB  1 
ATOM   2919 O OG  . SER B 1 81  ? -8.766  9.204   -4.050  1.00  28.51 ? 81   SER B OG  1 
ATOM   2920 N N   . ALA B 1 82  ? -10.414 4.770   -3.205  1.00  26.28 ? 82   ALA B N   1 
ATOM   2921 C CA  . ALA B 1 82  ? -10.367 3.476   -2.541  1.00  25.96 ? 82   ALA B CA  1 
ATOM   2922 C C   . ALA B 1 82  ? -8.938  2.929   -2.612  1.00  25.81 ? 82   ALA B C   1 
ATOM   2923 O O   . ALA B 1 82  ? -8.297  2.978   -3.659  1.00  25.54 ? 82   ALA B O   1 
ATOM   2924 C CB  . ALA B 1 82  ? -11.350 2.500   -3.179  1.00  25.70 ? 82   ALA B CB  1 
ATOM   2925 N N   . SER B 1 83  ? -8.451  2.437   -1.479  1.00  25.89 ? 83   SER B N   1 
ATOM   2926 C CA  . SER B 1 83  ? -7.145  1.820   -1.339  1.00  25.96 ? 83   SER B CA  1 
ATOM   2927 C C   . SER B 1 83  ? -6.981  0.615   -2.266  1.00  26.33 ? 83   SER B C   1 
ATOM   2928 O O   . SER B 1 83  ? -5.895  0.401   -2.825  1.00  26.07 ? 83   SER B O   1 
ATOM   2929 C CB  . SER B 1 83  ? -6.960  1.432   0.138   1.00  26.35 ? 83   SER B CB  1 
ATOM   2930 O OG  . SER B 1 83  ? -5.948  0.463   0.395   1.00  27.22 ? 83   SER B OG  1 
ATOM   2931 N N   . ARG B 1 84  ? -8.061  -0.161  -2.430  1.00  26.63 ? 84   ARG B N   1 
ATOM   2932 C CA  . ARG B 1 84  ? -8.072  -1.376  -3.258  1.00  26.32 ? 84   ARG B CA  1 
ATOM   2933 C C   . ARG B 1 84  ? -9.521  -1.742  -3.578  1.00  25.91 ? 84   ARG B C   1 
ATOM   2934 O O   . ARG B 1 84  ? -10.387 -1.622  -2.702  1.00  26.59 ? 84   ARG B O   1 
ATOM   2935 C CB  . ARG B 1 84  ? -7.359  -2.513  -2.513  1.00  26.58 ? 84   ARG B CB  1 
ATOM   2936 C CG  . ARG B 1 84  ? -7.108  -3.807  -3.322  1.00  28.30 ? 84   ARG B CG  1 
ATOM   2937 C CD  . ARG B 1 84  ? -6.193  -4.821  -2.560  1.00  31.03 ? 84   ARG B CD  1 
ATOM   2938 N NE  . ARG B 1 84  ? -6.826  -5.295  -1.327  1.00  33.17 ? 84   ARG B NE  1 
ATOM   2939 C CZ  . ARG B 1 84  ? -6.414  -6.322  -0.593  1.00  33.30 ? 84   ARG B CZ  1 
ATOM   2940 N NH1 . ARG B 1 84  ? -5.349  -7.029  -0.950  1.00  33.27 ? 84   ARG B NH1 1 
ATOM   2941 N NH2 . ARG B 1 84  ? -7.093  -6.645  0.499   1.00  33.23 ? 84   ARG B NH2 1 
ATOM   2942 N N   . VAL B 1 85  ? -9.804  -2.156  -4.817  1.00  24.87 ? 85   VAL B N   1 
ATOM   2943 C CA  . VAL B 1 85  ? -11.173 -2.542  -5.214  1.00  24.33 ? 85   VAL B CA  1 
ATOM   2944 C C   . VAL B 1 85  ? -11.200 -4.010  -5.650  1.00  24.47 ? 85   VAL B C   1 
ATOM   2945 O O   . VAL B 1 85  ? -10.506 -4.393  -6.605  1.00  24.49 ? 85   VAL B O   1 
ATOM   2946 C CB  . VAL B 1 85  ? -11.729 -1.648  -6.379  1.00  24.24 ? 85   VAL B CB  1 
ATOM   2947 C CG1 . VAL B 1 85  ? -13.172 -2.080  -6.761  1.00  25.02 ? 85   VAL B CG1 1 
ATOM   2948 C CG2 . VAL B 1 85  ? -11.707 -0.167  -6.040  1.00  23.54 ? 85   VAL B CG2 1 
ATOM   2949 N N   . THR B 1 86  ? -11.972 -4.846  -4.960  1.00  24.38 ? 86   THR B N   1 
ATOM   2950 C CA  . THR B 1 86  ? -12.059 -6.258  -5.362  1.00  24.79 ? 86   THR B CA  1 
ATOM   2951 C C   . THR B 1 86  ? -13.416 -6.530  -5.949  1.00  24.86 ? 86   THR B C   1 
ATOM   2952 O O   . THR B 1 86  ? -14.415 -6.057  -5.413  1.00  25.94 ? 86   THR B O   1 
ATOM   2953 C CB  . THR B 1 86  ? -11.863 -7.203  -4.186  1.00  24.51 ? 86   THR B CB  1 
ATOM   2954 O OG1 . THR B 1 86  ? -10.532 -7.056  -3.702  1.00  25.76 ? 86   THR B OG1 1 
ATOM   2955 C CG2 . THR B 1 86  ? -12.062 -8.634  -4.620  1.00  23.74 ? 86   THR B CG2 1 
ATOM   2956 N N   . ALA B 1 87  ? -13.461 -7.265  -7.048  1.00  24.69 ? 87   ALA B N   1 
ATOM   2957 C CA  . ALA B 1 87  ? -14.728 -7.697  -7.610  1.00  25.00 ? 87   ALA B CA  1 
ATOM   2958 C C   . ALA B 1 87  ? -14.992 -9.105  -7.099  1.00  25.45 ? 87   ALA B C   1 
ATOM   2959 O O   . ALA B 1 87  ? -14.140 -9.998  -7.206  1.00  25.49 ? 87   ALA B O   1 
ATOM   2960 C CB  . ALA B 1 87  ? -14.688 -7.666  -9.125  1.00  24.92 ? 87   ALA B CB  1 
ATOM   2961 N N   . VAL B 1 88  ? -16.147 -9.287  -6.477  1.00  26.05 ? 88   VAL B N   1 
ATOM   2962 C CA  . VAL B 1 88  ? -16.519 -10.594 -5.990  1.00  26.76 ? 88   VAL B CA  1 
ATOM   2963 C C   . VAL B 1 88  ? -17.618 -11.034 -6.929  1.00  27.49 ? 88   VAL B C   1 
ATOM   2964 O O   . VAL B 1 88  ? -18.740 -10.526 -6.871  1.00  27.13 ? 88   VAL B O   1 
ATOM   2965 C CB  . VAL B 1 88  ? -16.964 -10.549 -4.531  1.00  26.87 ? 88   VAL B CB  1 
ATOM   2966 C CG1 . VAL B 1 88  ? -17.453 -11.938 -4.052  1.00  27.38 ? 88   VAL B CG1 1 
ATOM   2967 C CG2 . VAL B 1 88  ? -15.825 -10.043 -3.658  1.00  26.54 ? 88   VAL B CG2 1 
ATOM   2968 N N   . ILE B 1 89  ? -17.256 -11.930 -7.845  1.00  28.37 ? 89   ILE B N   1 
ATOM   2969 C CA  . ILE B 1 89  ? -18.123 -12.296 -8.945  1.00  29.59 ? 89   ILE B CA  1 
ATOM   2970 C C   . ILE B 1 89  ? -18.354 -13.785 -8.826  1.00  30.74 ? 89   ILE B C   1 
ATOM   2971 O O   . ILE B 1 89  ? -17.705 -14.581 -9.515  1.00  30.83 ? 89   ILE B O   1 
ATOM   2972 C CB  . ILE B 1 89  ? -17.501 -11.973 -10.321 1.00  29.37 ? 89   ILE B CB  1 
ATOM   2973 C CG1 . ILE B 1 89  ? -17.308 -10.487 -10.515 1.00  28.92 ? 89   ILE B CG1 1 
ATOM   2974 C CG2 . ILE B 1 89  ? -18.421 -12.378 -11.418 1.00  30.46 ? 89   ILE B CG2 1 
ATOM   2975 C CD1 . ILE B 1 89  ? -16.650 -10.182 -11.832 1.00  30.02 ? 89   ILE B CD1 1 
ATOM   2976 N N   . PRO B 1 90  ? -19.289 -14.181 -7.943  1.00  31.98 ? 90   PRO B N   1 
ATOM   2977 C CA  . PRO B 1 90  ? -19.470 -15.609 -7.717  1.00  32.58 ? 90   PRO B CA  1 
ATOM   2978 C C   . PRO B 1 90  ? -19.625 -16.343 -9.059  1.00  33.52 ? 90   PRO B C   1 
ATOM   2979 O O   . PRO B 1 90  ? -18.934 -17.329 -9.270  1.00  33.87 ? 90   PRO B O   1 
ATOM   2980 C CB  . PRO B 1 90  ? -20.740 -15.675 -6.861  1.00  32.39 ? 90   PRO B CB  1 
ATOM   2981 C CG  . PRO B 1 90  ? -20.892 -14.304 -6.295  1.00  32.01 ? 90   PRO B CG  1 
ATOM   2982 C CD  . PRO B 1 90  ? -20.365 -13.384 -7.317  1.00  31.96 ? 90   PRO B CD  1 
ATOM   2983 N N   . CYS B 1 91  ? -20.472 -15.839 -9.965  1.00  34.42 ? 91   CYS B N   1 
ATOM   2984 C CA  . CYS B 1 91  ? -20.587 -16.406 -11.321 1.00  35.97 ? 91   CYS B CA  1 
ATOM   2985 C C   . CYS B 1 91  ? -20.028 -15.507 -12.449 1.00  35.77 ? 91   CYS B C   1 
ATOM   2986 O O   . CYS B 1 91  ? -20.627 -14.496 -12.796 1.00  36.07 ? 91   CYS B O   1 
ATOM   2987 C CB  . CYS B 1 91  ? -22.034 -16.816 -11.655 1.00  36.11 ? 91   CYS B CB  1 
ATOM   2988 S SG  . CYS B 1 91  ? -22.133 -17.497 -13.350 1.00  39.89 ? 91   CYS B SG  1 
ATOM   2989 N N   . PHE B 1 92  ? -18.915 -15.916 -13.047 1.00  35.70 ? 92   PHE B N   1 
ATOM   2990 C CA  . PHE B 1 92  ? -18.198 -15.090 -14.021 1.00  35.90 ? 92   PHE B CA  1 
ATOM   2991 C C   . PHE B 1 92  ? -18.887 -14.958 -15.381 1.00  36.69 ? 92   PHE B C   1 
ATOM   2992 O O   . PHE B 1 92  ? -19.003 -15.928 -16.136 1.00  36.78 ? 92   PHE B O   1 
ATOM   2993 C CB  . PHE B 1 92  ? -16.774 -15.623 -14.213 1.00  35.61 ? 92   PHE B CB  1 
ATOM   2994 C CG  . PHE B 1 92  ? -15.799 -14.607 -14.727 1.00  33.64 ? 92   PHE B CG  1 
ATOM   2995 C CD1 . PHE B 1 92  ? -15.097 -13.782 -13.848 1.00  32.61 ? 92   PHE B CD1 1 
ATOM   2996 C CD2 . PHE B 1 92  ? -15.550 -14.500 -16.088 1.00  33.22 ? 92   PHE B CD2 1 
ATOM   2997 C CE1 . PHE B 1 92  ? -14.184 -12.854 -14.323 1.00  31.76 ? 92   PHE B CE1 1 
ATOM   2998 C CE2 . PHE B 1 92  ? -14.638 -13.575 -16.588 1.00  32.22 ? 92   PHE B CE2 1 
ATOM   2999 C CZ  . PHE B 1 92  ? -13.957 -12.750 -15.704 1.00  32.99 ? 92   PHE B CZ  1 
ATOM   3000 N N   . PRO B 1 93  ? -19.307 -13.737 -15.727 1.00  37.65 ? 93   PRO B N   1 
ATOM   3001 C CA  . PRO B 1 93  ? -20.035 -13.511 -16.986 1.00  38.39 ? 93   PRO B CA  1 
ATOM   3002 C C   . PRO B 1 93  ? -19.226 -13.842 -18.231 1.00  38.97 ? 93   PRO B C   1 
ATOM   3003 O O   . PRO B 1 93  ? -18.027 -13.574 -18.279 1.00  38.92 ? 93   PRO B O   1 
ATOM   3004 C CB  . PRO B 1 93  ? -20.368 -12.007 -16.960 1.00  38.19 ? 93   PRO B CB  1 
ATOM   3005 C CG  . PRO B 1 93  ? -19.474 -11.406 -15.946 1.00  38.24 ? 93   PRO B CG  1 
ATOM   3006 C CD  . PRO B 1 93  ? -19.100 -12.488 -14.961 1.00  37.81 ? 93   PRO B CD  1 
ATOM   3007 N N   . TYR B 1 94  ? -19.895 -14.424 -19.227 1.00  39.75 ? 94   TYR B N   1 
ATOM   3008 C CA  . TYR B 1 94  ? -19.274 -14.797 -20.498 1.00  40.15 ? 94   TYR B CA  1 
ATOM   3009 C C   . TYR B 1 94  ? -18.150 -15.824 -20.352 1.00  40.75 ? 94   TYR B C   1 
ATOM   3010 O O   . TYR B 1 94  ? -17.320 -15.969 -21.257 1.00  41.25 ? 94   TYR B O   1 
ATOM   3011 C CB  . TYR B 1 94  ? -18.778 -13.553 -21.247 1.00  40.21 ? 94   TYR B CB  1 
ATOM   3012 C CG  . TYR B 1 94  ? -19.888 -12.679 -21.782 1.00  40.28 ? 94   TYR B CG  1 
ATOM   3013 C CD1 . TYR B 1 94  ? -20.509 -11.728 -20.975 1.00  39.74 ? 94   TYR B CD1 1 
ATOM   3014 C CD2 . TYR B 1 94  ? -20.321 -12.804 -23.101 1.00  40.52 ? 94   TYR B CD2 1 
ATOM   3015 C CE1 . TYR B 1 94  ? -21.539 -10.932 -21.466 1.00  38.73 ? 94   TYR B CE1 1 
ATOM   3016 C CE2 . TYR B 1 94  ? -21.351 -12.006 -23.598 1.00  39.83 ? 94   TYR B CE2 1 
ATOM   3017 C CZ  . TYR B 1 94  ? -21.954 -11.080 -22.771 1.00  38.19 ? 94   TYR B CZ  1 
ATOM   3018 O OH  . TYR B 1 94  ? -22.969 -10.293 -23.253 1.00  37.44 ? 94   TYR B OH  1 
ATOM   3019 N N   . ALA B 1 95  ? -18.137 -16.540 -19.227 1.00  41.28 ? 95   ALA B N   1 
ATOM   3020 C CA  . ALA B 1 95  ? -17.172 -17.616 -18.990 1.00  41.83 ? 95   ALA B CA  1 
ATOM   3021 C C   . ALA B 1 95  ? -17.191 -18.714 -20.062 1.00  42.43 ? 95   ALA B C   1 
ATOM   3022 O O   . ALA B 1 95  ? -16.129 -19.094 -20.561 1.00  43.15 ? 95   ALA B O   1 
ATOM   3023 C CB  . ALA B 1 95  ? -17.369 -18.211 -17.620 1.00  41.77 ? 95   ALA B CB  1 
ATOM   3024 N N   . ARG B 1 96  ? -18.376 -19.200 -20.438 0.95  42.72 ? 96   ARG B N   1 
ATOM   3025 C CA  . ARG B 1 96  ? -18.497 -20.183 -21.527 0.95  43.31 ? 96   ARG B CA  1 
ATOM   3026 C C   . ARG B 1 96  ? -17.971 -19.668 -22.868 0.95  43.20 ? 96   ARG B C   1 
ATOM   3027 O O   . ARG B 1 96  ? -18.087 -20.359 -23.884 0.95  43.05 ? 96   ARG B O   1 
ATOM   3028 C CB  . ARG B 1 96  ? -19.954 -20.622 -21.721 0.95  43.68 ? 96   ARG B CB  1 
ATOM   3029 C CG  . ARG B 1 96  ? -20.483 -21.598 -20.672 0.95  45.60 ? 96   ARG B CG  1 
ATOM   3030 C CD  . ARG B 1 96  ? -21.982 -21.813 -20.857 0.95  48.65 ? 96   ARG B CD  1 
ATOM   3031 N NE  . ARG B 1 96  ? -22.719 -20.544 -20.928 0.95  51.18 ? 96   ARG B NE  1 
ATOM   3032 C CZ  . ARG B 1 96  ? -23.916 -20.391 -21.499 0.95  51.56 ? 96   ARG B CZ  1 
ATOM   3033 N NH1 . ARG B 1 96  ? -24.531 -21.431 -22.058 0.95  52.15 ? 96   ARG B NH1 1 
ATOM   3034 N NH2 . ARG B 1 96  ? -24.504 -19.197 -21.514 0.95  50.01 ? 96   ARG B NH2 1 
ATOM   3035 N N   . GLN B 1 97  ? -17.424 -18.449 -22.871 0.73  43.35 ? 97   GLN B N   1 
ATOM   3036 C CA  . GLN B 1 97  ? -16.885 -17.827 -24.094 0.73  43.38 ? 97   GLN B CA  1 
ATOM   3037 C C   . GLN B 1 97  ? -15.366 -17.576 -24.023 0.73  43.35 ? 97   GLN B C   1 
ATOM   3038 O O   . GLN B 1 97  ? -14.859 -16.528 -24.446 0.73  43.19 ? 97   GLN B O   1 
ATOM   3039 C CB  . GLN B 1 97  ? -17.689 -16.574 -24.471 0.73  43.16 ? 97   GLN B CB  1 
ATOM   3040 C CG  . GLN B 1 97  ? -18.972 -16.926 -25.227 0.73  43.18 ? 97   GLN B CG  1 
ATOM   3041 C CD  . GLN B 1 97  ? -19.934 -15.756 -25.412 0.73  43.06 ? 97   GLN B CD  1 
ATOM   3042 O OE1 . GLN B 1 97  ? -19.586 -14.721 -25.999 0.73  41.63 ? 97   GLN B OE1 1 
ATOM   3043 N NE2 . GLN B 1 97  ? -21.168 -15.938 -24.935 0.73  42.58 ? 97   GLN B NE2 1 
ATOM   3044 N N   . ASP B 1 98  ? -14.654 -18.578 -23.518 0.10  43.51 ? 98   ASP B N   1 
ATOM   3045 C CA  . ASP B 1 98  ? -13.233 -18.465 -23.216 0.10  43.77 ? 98   ASP B CA  1 
ATOM   3046 C C   . ASP B 1 98  ? -12.321 -18.836 -24.381 0.10  44.08 ? 98   ASP B C   1 
ATOM   3047 O O   . ASP B 1 98  ? -11.112 -18.620 -24.315 0.10  44.04 ? 98   ASP B O   1 
ATOM   3048 C CB  . ASP B 1 98  ? -12.898 -19.357 -22.023 0.10  43.72 ? 98   ASP B CB  1 
ATOM   3049 C CG  . ASP B 1 98  ? -13.370 -20.783 -22.218 0.10  43.62 ? 98   ASP B CG  1 
ATOM   3050 O OD1 . ASP B 1 98  ? -14.286 -21.002 -23.039 0.10  43.58 ? 98   ASP B OD1 1 
ATOM   3051 O OD2 . ASP B 1 98  ? -12.828 -21.687 -21.555 0.10  43.65 ? 98   ASP B OD2 1 
ATOM   3052 N N   . LYS B 1 99  ? -12.891 -19.406 -25.437 0.010 44.61 ? 99   LYS B N   1 
ATOM   3053 C CA  . LYS B 1 99  ? -12.088 -19.823 -26.579 0.010 45.19 ? 99   LYS B CA  1 
ATOM   3054 C C   . LYS B 1 99  ? -12.760 -19.552 -27.921 0.010 45.77 ? 99   LYS B C   1 
ATOM   3055 O O   . LYS B 1 99  ? -13.966 -19.310 -27.993 0.010 45.78 ? 99   LYS B O   1 
ATOM   3056 C CB  . LYS B 1 99  ? -11.687 -21.297 -26.455 0.010 45.07 ? 99   LYS B CB  1 
ATOM   3057 C CG  . LYS B 1 99  ? -12.845 -22.256 -26.254 0.010 44.91 ? 99   LYS B CG  1 
ATOM   3058 C CD  . LYS B 1 99  ? -12.335 -23.657 -25.952 0.010 44.60 ? 99   LYS B CD  1 
ATOM   3059 C CE  . LYS B 1 99  ? -13.454 -24.577 -25.498 0.010 44.49 ? 99   LYS B CE  1 
ATOM   3060 N NZ  . LYS B 1 99  ? -12.926 -25.887 -25.020 0.010 44.32 ? 99   LYS B NZ  1 
ATOM   3061 N N   . LYS B 1 100 ? -11.953 -19.595 -28.976 0.010 46.75 ? 100  LYS B N   1 
ATOM   3062 C CA  . LYS B 1 100 ? -12.398 -19.327 -30.342 0.010 47.35 ? 100  LYS B CA  1 
ATOM   3063 C C   . LYS B 1 100 ? -13.232 -20.466 -30.963 0.010 47.56 ? 100  LYS B C   1 
ATOM   3064 O O   . LYS B 1 100 ? -14.071 -20.212 -31.844 0.010 48.01 ? 100  LYS B O   1 
ATOM   3065 C CB  . LYS B 1 100 ? -11.181 -19.047 -31.228 0.010 47.62 ? 100  LYS B CB  1 
ATOM   3066 C CG  . LYS B 1 100 ? -10.689 -17.608 -31.239 0.010 47.90 ? 100  LYS B CG  1 
ATOM   3067 C CD  . LYS B 1 100 ? -9.557  -17.472 -32.247 0.010 48.47 ? 100  LYS B CD  1 
ATOM   3068 C CE  . LYS B 1 100 ? -9.670  -16.184 -33.046 0.010 49.82 ? 100  LYS B CE  1 
ATOM   3069 N NZ  . LYS B 1 100 ? -8.470  -15.955 -33.916 0.010 50.62 ? 100  LYS B NZ  1 
ATOM   3070 N N   . ASP B 1 101 ? -12.980 -21.700 -30.515 0.010 47.22 ? 101  ASP B N   1 
ATOM   3071 C CA  . ASP B 1 101 ? -13.688 -22.908 -30.979 0.010 46.93 ? 101  ASP B CA  1 
ATOM   3072 C C   . ASP B 1 101 ? -13.730 -23.053 -32.499 0.010 46.81 ? 101  ASP B C   1 
ATOM   3073 O O   . ASP B 1 101 ? -14.810 -23.139 -33.090 0.010 46.76 ? 101  ASP B O   1 
ATOM   3074 C CB  . ASP B 1 101 ? -15.108 -22.967 -30.406 0.010 46.91 ? 101  ASP B CB  1 
ATOM   3075 C CG  . ASP B 1 101 ? -15.125 -23.260 -28.921 0.010 46.84 ? 101  ASP B CG  1 
ATOM   3076 O OD1 . ASP B 1 101 ? -14.218 -23.975 -28.443 0.010 46.80 ? 101  ASP B OD1 1 
ATOM   3077 O OD2 . ASP B 1 101 ? -16.048 -22.779 -28.230 0.010 46.81 ? 101  ASP B OD2 1 
ATOM   3078 N N   . LYS B 1 102 ? -12.547 -23.083 -33.110 1.00  46.67 ? 102  LYS B N   1 
ATOM   3079 C CA  . LYS B 1 102 ? -12.389 -23.165 -34.579 1.00  46.74 ? 102  LYS B CA  1 
ATOM   3080 C C   . LYS B 1 102 ? -13.172 -22.098 -35.375 1.00  45.89 ? 102  LYS B C   1 
ATOM   3081 O O   . LYS B 1 102 ? -13.222 -22.154 -36.603 1.00  45.71 ? 102  LYS B O   1 
ATOM   3082 C CB  . LYS B 1 102 ? -12.788 -24.556 -35.104 1.00  47.29 ? 102  LYS B CB  1 
ATOM   3083 C CG  . LYS B 1 102 ? -11.759 -25.665 -34.907 1.00  48.36 ? 102  LYS B CG  1 
ATOM   3084 C CD  . LYS B 1 102 ? -11.839 -26.688 -36.061 1.00  52.06 ? 102  LYS B CD  1 
ATOM   3085 C CE  . LYS B 1 102 ? -13.184 -27.466 -36.092 1.00  53.61 ? 102  LYS B CE  1 
ATOM   3086 N NZ  . LYS B 1 102 ? -13.470 -28.165 -37.397 1.00  53.66 ? 102  LYS B NZ  1 
ATOM   3087 N N   . SER B 1 103 ? -13.783 -21.149 -34.669 0.68  45.04 ? 103  SER B N   1 
ATOM   3088 C CA  . SER B 1 103 ? -14.645 -20.147 -35.297 0.68  44.21 ? 103  SER B CA  1 
ATOM   3089 C C   . SER B 1 103 ? -14.008 -18.750 -35.286 0.68  43.84 ? 103  SER B C   1 
ATOM   3090 O O   . SER B 1 103 ? -12.935 -18.545 -34.705 0.68  43.80 ? 103  SER B O   1 
ATOM   3091 C CB  . SER B 1 103 ? -16.028 -20.121 -34.633 0.68  44.23 ? 103  SER B CB  1 
ATOM   3092 O OG  . SER B 1 103 ? -16.842 -19.087 -35.161 0.68  43.35 ? 103  SER B OG  1 
ATOM   3093 N N   . ARG B 1 104 ? -14.690 -17.806 -35.939 1.00  43.21 ? 104  ARG B N   1 
ATOM   3094 C CA  . ARG B 1 104 ? -14.269 -16.412 -36.061 1.00  42.39 ? 104  ARG B CA  1 
ATOM   3095 C C   . ARG B 1 104 ? -14.993 -15.625 -34.983 1.00  42.28 ? 104  ARG B C   1 
ATOM   3096 O O   . ARG B 1 104 ? -15.603 -14.579 -35.251 1.00  42.24 ? 104  ARG B O   1 
ATOM   3097 C CB  . ARG B 1 104 ? -14.660 -15.894 -37.441 1.00  42.11 ? 104  ARG B CB  1 
ATOM   3098 C CG  . ARG B 1 104 ? -13.748 -14.815 -38.004 1.00  42.71 ? 104  ARG B CG  1 
ATOM   3099 C CD  . ARG B 1 104 ? -13.226 -15.185 -39.388 1.00  42.80 ? 104  ARG B CD  1 
ATOM   3100 N NE  . ARG B 1 104 ? -14.300 -15.671 -40.251 1.00  44.23 ? 104  ARG B NE  1 
ATOM   3101 C CZ  . ARG B 1 104 ? -14.112 -16.364 -41.367 1.00  44.69 ? 104  ARG B CZ  1 
ATOM   3102 N NH1 . ARG B 1 104 ? -12.884 -16.653 -41.763 1.00  45.74 ? 104  ARG B NH1 1 
ATOM   3103 N NH2 . ARG B 1 104 ? -15.152 -16.770 -42.086 1.00  44.91 ? 104  ARG B NH2 1 
ATOM   3104 N N   . ALA B 1 105 ? -14.932 -16.153 -33.760 1.00  41.84 ? 105  ALA B N   1 
ATOM   3105 C CA  . ALA B 1 105 ? -15.740 -15.666 -32.647 1.00  41.24 ? 105  ALA B CA  1 
ATOM   3106 C C   . ALA B 1 105 ? -14.873 -15.005 -31.579 1.00  40.96 ? 105  ALA B C   1 
ATOM   3107 O O   . ALA B 1 105 ? -13.660 -15.256 -31.507 1.00  41.38 ? 105  ALA B O   1 
ATOM   3108 C CB  . ALA B 1 105 ? -16.541 -16.811 -32.044 1.00  41.42 ? 105  ALA B CB  1 
ATOM   3109 N N   . PRO B 1 106 ? -15.486 -14.154 -30.738 0.86  40.20 ? 106  PRO B N   1 
ATOM   3110 C CA  . PRO B 1 106 ? -14.704 -13.424 -29.753 0.86  39.48 ? 106  PRO B CA  1 
ATOM   3111 C C   . PRO B 1 106 ? -14.310 -14.322 -28.590 0.86  38.56 ? 106  PRO B C   1 
ATOM   3112 O O   . PRO B 1 106 ? -14.945 -15.356 -28.371 0.86  38.32 ? 106  PRO B O   1 
ATOM   3113 C CB  . PRO B 1 106 ? -15.687 -12.363 -29.276 0.86  39.44 ? 106  PRO B CB  1 
ATOM   3114 C CG  . PRO B 1 106 ? -17.006 -13.076 -29.345 0.86  39.97 ? 106  PRO B CG  1 
ATOM   3115 C CD  . PRO B 1 106 ? -16.929 -13.874 -30.604 0.86  40.16 ? 106  PRO B CD  1 
ATOM   3116 N N   . ILE B 1 107 ? -13.259 -13.943 -27.869 1.00  37.76 ? 107  ILE B N   1 
ATOM   3117 C CA  . ILE B 1 107 ? -12.990 -14.549 -26.556 1.00  37.09 ? 107  ILE B CA  1 
ATOM   3118 C C   . ILE B 1 107 ? -13.591 -13.642 -25.469 1.00  36.49 ? 107  ILE B C   1 
ATOM   3119 O O   . ILE B 1 107 ? -12.876 -12.984 -24.686 1.00  36.28 ? 107  ILE B O   1 
ATOM   3120 C CB  . ILE B 1 107 ? -11.491 -14.819 -26.302 1.00  36.99 ? 107  ILE B CB  1 
ATOM   3121 C CG1 . ILE B 1 107 ? -10.937 -15.794 -27.339 1.00  36.62 ? 107  ILE B CG1 1 
ATOM   3122 C CG2 . ILE B 1 107 ? -11.293 -15.368 -24.892 1.00  37.09 ? 107  ILE B CG2 1 
ATOM   3123 C CD1 . ILE B 1 107 ? -9.527  -16.229 -27.060 1.00  36.18 ? 107  ILE B CD1 1 
ATOM   3124 N N   . SER B 1 108 ? -14.918 -13.613 -25.447 1.00  35.31 ? 108  SER B N   1 
ATOM   3125 C CA  . SER B 1 108 ? -15.661 -12.684 -24.616 1.00  34.48 ? 108  SER B CA  1 
ATOM   3126 C C   . SER B 1 108 ? -15.163 -12.586 -23.173 1.00  33.76 ? 108  SER B C   1 
ATOM   3127 O O   . SER B 1 108 ? -15.101 -11.484 -22.627 1.00  34.02 ? 108  SER B O   1 
ATOM   3128 C CB  . SER B 1 108 ? -17.135 -13.030 -24.652 1.00  34.39 ? 108  SER B CB  1 
ATOM   3129 O OG  . SER B 1 108 ? -17.523 -13.195 -26.030 1.00  34.92 ? 108  SER B OG  1 
ATOM   3130 N N   . ALA B 1 109 ? -14.810 -13.731 -22.583 1.00  32.31 ? 109  ALA B N   1 
ATOM   3131 C CA  . ALA B 1 109 ? -14.231 -13.805 -21.242 1.00  31.00 ? 109  ALA B CA  1 
ATOM   3132 C C   . ALA B 1 109 ? -12.948 -12.972 -21.080 1.00  30.41 ? 109  ALA B C   1 
ATOM   3133 O O   . ALA B 1 109 ? -12.759 -12.296 -20.071 1.00  30.22 ? 109  ALA B O   1 
ATOM   3134 C CB  . ALA B 1 109 ? -13.968 -15.250 -20.870 1.00  30.77 ? 109  ALA B CB  1 
ATOM   3135 N N   . LYS B 1 110 ? -12.075 -13.005 -22.079 1.00  29.94 ? 110  LYS B N   1 
ATOM   3136 C CA  . LYS B 1 110 ? -10.848 -12.200 -22.048 1.00  29.46 ? 110  LYS B CA  1 
ATOM   3137 C C   . LYS B 1 110 ? -11.146 -10.711 -22.229 1.00  29.12 ? 110  LYS B C   1 
ATOM   3138 O O   . LYS B 1 110 ? -10.387 -9.816  -21.744 1.00  29.84 ? 110  LYS B O   1 
ATOM   3139 C CB  . LYS B 1 110 ? -9.866  -12.659 -23.131 1.00  29.29 ? 110  LYS B CB  1 
ATOM   3140 C CG  . LYS B 1 110 ? -8.606  -11.808 -23.243 1.00  29.52 ? 110  LYS B CG  1 
ATOM   3141 C CD  . LYS B 1 110 ? -7.721  -11.966 -21.994 1.00  29.70 ? 110  LYS B CD  1 
ATOM   3142 C CE  . LYS B 1 110 ? -6.601  -10.923 -21.910 1.00  30.22 ? 110  LYS B CE  1 
ATOM   3143 N NZ  . LYS B 1 110 ? -5.509  -11.188 -22.904 1.00  30.13 ? 110  LYS B NZ  1 
ATOM   3144 N N   . LEU B 1 111 ? -12.226 -10.439 -22.970 1.00  28.48 ? 111  LEU B N   1 
ATOM   3145 C CA  . LEU B 1 111 ? -12.715 -9.088  -23.103 1.00  27.48 ? 111  LEU B CA  1 
ATOM   3146 C C   . LEU B 1 111 ? -13.224 -8.638  -21.737 1.00  26.92 ? 111  LEU B C   1 
ATOM   3147 O O   . LEU B 1 111 ? -12.743 -7.657  -21.202 1.00  26.95 ? 111  LEU B O   1 
ATOM   3148 C CB  . LEU B 1 111 ? -13.805 -9.040  -24.175 1.00  27.44 ? 111  LEU B CB  1 
ATOM   3149 C CG  . LEU B 1 111 ? -14.652 -7.780  -24.384 1.00  27.50 ? 111  LEU B CG  1 
ATOM   3150 C CD1 . LEU B 1 111 ? -13.818 -6.562  -24.789 1.00  27.21 ? 111  LEU B CD1 1 
ATOM   3151 C CD2 . LEU B 1 111 ? -15.741 -8.077  -25.439 1.00  28.61 ? 111  LEU B CD2 1 
ATOM   3152 N N   . VAL B 1 112 ? -14.157 -9.379  -21.150 1.00  26.29 ? 112  VAL B N   1 
ATOM   3153 C CA  . VAL B 1 112 ? -14.658 -9.047  -19.822 1.00  25.75 ? 112  VAL B CA  1 
ATOM   3154 C C   . VAL B 1 112 ? -13.495 -8.918  -18.836 1.00  25.84 ? 112  VAL B C   1 
ATOM   3155 O O   . VAL B 1 112 ? -13.439 -7.956  -18.034 1.00  25.99 ? 112  VAL B O   1 
ATOM   3156 C CB  . VAL B 1 112 ? -15.693 -10.068 -19.281 1.00  25.75 ? 112  VAL B CB  1 
ATOM   3157 C CG1 . VAL B 1 112 ? -16.315 -9.542  -17.986 1.00  24.78 ? 112  VAL B CG1 1 
ATOM   3158 C CG2 . VAL B 1 112 ? -16.798 -10.358 -20.317 1.00  25.62 ? 112  VAL B CG2 1 
ATOM   3159 N N   . ALA B 1 113 ? -12.559 -9.869  -18.910 1.00  25.18 ? 113  ALA B N   1 
ATOM   3160 C CA  . ALA B 1 113 ? -11.344 -9.791  -18.114 1.00  24.88 ? 113  ALA B CA  1 
ATOM   3161 C C   . ALA B 1 113 ? -10.731 -8.404  -18.277 1.00  25.00 ? 113  ALA B C   1 
ATOM   3162 O O   . ALA B 1 113 ? -10.412 -7.701  -17.287 1.00  25.80 ? 113  ALA B O   1 
ATOM   3163 C CB  . ALA B 1 113 ? -10.345 -10.873 -18.551 1.00  24.47 ? 113  ALA B CB  1 
ATOM   3164 N N   . ASN B 1 114 ? -10.594 -7.997  -19.534 1.00  24.81 ? 114  ASN B N   1 
ATOM   3165 C CA  . ASN B 1 114 ? -9.975  -6.728  -19.865 1.00  24.68 ? 114  ASN B CA  1 
ATOM   3166 C C   . ASN B 1 114 ? -10.773 -5.547  -19.352 1.00  24.67 ? 114  ASN B C   1 
ATOM   3167 O O   . ASN B 1 114 ? -10.202 -4.591  -18.813 1.00  25.66 ? 114  ASN B O   1 
ATOM   3168 C CB  . ASN B 1 114 ? -9.809  -6.580  -21.366 1.00  25.00 ? 114  ASN B CB  1 
ATOM   3169 C CG  . ASN B 1 114 ? -8.523  -7.189  -21.890 1.00  25.19 ? 114  ASN B CG  1 
ATOM   3170 O OD1 . ASN B 1 114 ? -7.627  -7.544  -21.125 1.00  24.60 ? 114  ASN B OD1 1 
ATOM   3171 N ND2 . ASN B 1 114 ? -8.425  -7.285  -23.231 1.00  25.78 ? 114  ASN B ND2 1 
ATOM   3172 N N   . MET B 1 115 ? -12.088 -5.591  -19.512 0.90  24.21 ? 115  MET B N   1 
ATOM   3173 C CA  . MET B 1 115 ? -12.923 -4.486  -19.043 0.90  23.96 ? 115  MET B CA  1 
ATOM   3174 C C   . MET B 1 115 ? -12.875 -4.334  -17.524 0.90  23.27 ? 115  MET B C   1 
ATOM   3175 O O   . MET B 1 115 ? -12.928 -3.227  -17.007 0.90  22.37 ? 115  MET B O   1 
ATOM   3176 C CB  . MET B 1 115 ? -14.363 -4.635  -19.547 0.90  24.44 ? 115  MET B CB  1 
ATOM   3177 C CG  . MET B 1 115 ? -14.451 -4.732  -21.088 0.90  25.32 ? 115  MET B CG  1 
ATOM   3178 S SD  . MET B 1 115 ? -16.145 -4.854  -21.683 0.90  31.33 ? 115  MET B SD  1 
ATOM   3179 C CE  . MET B 1 115 ? -16.643 -6.427  -20.927 0.90  29.91 ? 115  MET B CE  1 
ATOM   3180 N N   . LEU B 1 116 ? -12.733 -5.456  -16.818 1.00  23.09 ? 116  LEU B N   1 
ATOM   3181 C CA  . LEU B 1 116 ? -12.678 -5.428  -15.353 1.00  22.73 ? 116  LEU B CA  1 
ATOM   3182 C C   . LEU B 1 116 ? -11.396 -4.761  -14.896 1.00  22.52 ? 116  LEU B C   1 
ATOM   3183 O O   . LEU B 1 116 ? -11.341 -4.078  -13.861 1.00  21.99 ? 116  LEU B O   1 
ATOM   3184 C CB  . LEU B 1 116 ? -12.812 -6.838  -14.769 1.00  22.41 ? 116  LEU B CB  1 
ATOM   3185 C CG  . LEU B 1 116 ? -14.226 -7.415  -14.825 1.00  22.35 ? 116  LEU B CG  1 
ATOM   3186 C CD1 . LEU B 1 116 ? -14.233 -8.951  -14.786 1.00  23.57 ? 116  LEU B CD1 1 
ATOM   3187 C CD2 . LEU B 1 116 ? -15.047 -6.847  -13.706 1.00  21.62 ? 116  LEU B CD2 1 
ATOM   3188 N N   . SER B 1 117 ? -10.367 -4.952  -15.707 1.00  22.80 ? 117  SER B N   1 
ATOM   3189 C CA  . SER B 1 117 ? -9.042  -4.450  -15.407 1.00  23.24 ? 117  SER B CA  1 
ATOM   3190 C C   . SER B 1 117 ? -8.989  -2.938  -15.597 1.00  23.64 ? 117  SER B C   1 
ATOM   3191 O O   . SER B 1 117 ? -8.719  -2.197  -14.630 1.00  24.04 ? 117  SER B O   1 
ATOM   3192 C CB  . SER B 1 117 ? -8.050  -5.190  -16.308 1.00  23.19 ? 117  SER B CB  1 
ATOM   3193 O OG  . SER B 1 117 ? -8.587  -6.482  -16.623 1.00  22.93 ? 117  SER B OG  1 
ATOM   3194 N N   . VAL B 1 118 ? -9.307  -2.479  -16.813 1.00  23.80 ? 118  VAL B N   1 
ATOM   3195 C CA  . VAL B 1 118 ? -9.297  -1.048  -17.113 1.00  24.15 ? 118  VAL B CA  1 
ATOM   3196 C C   . VAL B 1 118 ? -10.284 -0.247  -16.266 1.00  24.10 ? 118  VAL B C   1 
ATOM   3197 O O   . VAL B 1 118 ? -10.043 0.929   -16.023 1.00  25.50 ? 118  VAL B O   1 
ATOM   3198 C CB  . VAL B 1 118 ? -9.509  -0.699  -18.642 1.00  24.27 ? 118  VAL B CB  1 
ATOM   3199 C CG1 . VAL B 1 118 ? -8.902  -1.763  -19.545 1.00  25.35 ? 118  VAL B CG1 1 
ATOM   3200 C CG2 . VAL B 1 118 ? -11.001 -0.495  -18.996 1.00  24.37 ? 118  VAL B CG2 1 
ATOM   3201 N N   . ALA B 1 119 ? -11.388 -0.843  -15.831 1.00  23.35 ? 119  ALA B N   1 
ATOM   3202 C CA  . ALA B 1 119 ? -12.351 -0.078  -15.048 1.00  22.91 ? 119  ALA B CA  1 
ATOM   3203 C C   . ALA B 1 119 ? -11.772 0.181   -13.680 1.00  23.16 ? 119  ALA B C   1 
ATOM   3204 O O   . ALA B 1 119 ? -12.316 0.989   -12.926 1.00  23.49 ? 119  ALA B O   1 
ATOM   3205 C CB  . ALA B 1 119 ? -13.690 -0.788  -14.943 1.00  22.83 ? 119  ALA B CB  1 
ATOM   3206 N N   . GLY B 1 120 ? -10.656 -0.497  -13.383 1.00  23.26 ? 120  GLY B N   1 
ATOM   3207 C CA  . GLY B 1 120 ? -9.936  -0.334  -12.129 1.00  22.91 ? 120  GLY B CA  1 
ATOM   3208 C C   . GLY B 1 120 ? -10.019 -1.421  -11.061 1.00  23.20 ? 120  GLY B C   1 
ATOM   3209 O O   . GLY B 1 120 ? -9.838  -1.109  -9.890  1.00  23.61 ? 120  GLY B O   1 
ATOM   3210 N N   . ALA B 1 121 ? -10.266 -2.690  -11.415 1.00  23.04 ? 121  ALA B N   1 
ATOM   3211 C CA  . ALA B 1 121 ? -10.230 -3.769  -10.400 1.00  22.38 ? 121  ALA B CA  1 
ATOM   3212 C C   . ALA B 1 121 ? -8.784  -4.131  -10.034 1.00  22.17 ? 121  ALA B C   1 
ATOM   3213 O O   . ALA B 1 121 ? -7.910  -4.115  -10.884 1.00  21.60 ? 121  ALA B O   1 
ATOM   3214 C CB  . ALA B 1 121 ? -10.999 -4.992  -10.876 1.00  21.89 ? 121  ALA B CB  1 
ATOM   3215 N N   . ASP B 1 122 ? -8.528  -4.418  -8.759  1.00  22.89 ? 122  ASP B N   1 
ATOM   3216 C CA  . ASP B 1 122 ? -7.192  -4.836  -8.311  1.00  23.19 ? 122  ASP B CA  1 
ATOM   3217 C C   . ASP B 1 122 ? -7.158  -6.315  -8.037  1.00  23.61 ? 122  ASP B C   1 
ATOM   3218 O O   . ASP B 1 122 ? -6.112  -6.944  -8.085  1.00  24.15 ? 122  ASP B O   1 
ATOM   3219 C CB  . ASP B 1 122 ? -6.758  -4.103  -7.048  1.00  22.95 ? 122  ASP B CB  1 
ATOM   3220 C CG  . ASP B 1 122 ? -6.846  -2.600  -7.185  1.00  23.77 ? 122  ASP B CG  1 
ATOM   3221 O OD1 . ASP B 1 122 ? -6.112  -2.006  -7.994  1.00  25.43 ? 122  ASP B OD1 1 
ATOM   3222 O OD2 . ASP B 1 122 ? -7.667  -1.992  -6.475  1.00  27.08 ? 122  ASP B OD2 1 
ATOM   3223 N N   . HIS B 1 123 ? -8.313  -6.883  -7.754  1.00  24.40 ? 123  HIS B N   1 
ATOM   3224 C CA  . HIS B 1 123 ? -8.372  -8.264  -7.343  1.00  24.98 ? 123  HIS B CA  1 
ATOM   3225 C C   . HIS B 1 123 ? -9.703  -8.800  -7.879  1.00  25.22 ? 123  HIS B C   1 
ATOM   3226 O O   . HIS B 1 123 ? -10.658 -8.013  -8.179  1.00  26.10 ? 123  HIS B O   1 
ATOM   3227 C CB  . HIS B 1 123 ? -8.293  -8.271  -5.806  1.00  25.54 ? 123  HIS B CB  1 
ATOM   3228 C CG  . HIS B 1 123 ? -8.170  -9.627  -5.193  1.00  26.65 ? 123  HIS B CG  1 
ATOM   3229 N ND1 . HIS B 1 123 ? -7.554  -10.689 -5.819  1.00  27.24 ? 123  HIS B ND1 1 
ATOM   3230 C CD2 . HIS B 1 123 ? -8.546  -10.076 -3.972  1.00  29.02 ? 123  HIS B CD2 1 
ATOM   3231 C CE1 . HIS B 1 123 ? -7.586  -11.745 -5.025  1.00  28.80 ? 123  HIS B CE1 1 
ATOM   3232 N NE2 . HIS B 1 123 ? -8.179  -11.399 -3.893  1.00  30.33 ? 123  HIS B NE2 1 
ATOM   3233 N N   . ILE B 1 124 ? -9.762  -10.112 -8.077  1.00  24.77 ? 124  ILE B N   1 
ATOM   3234 C CA  . ILE B 1 124 ? -11.027 -10.765 -8.378  1.00  24.61 ? 124  ILE B CA  1 
ATOM   3235 C C   . ILE B 1 124 ? -11.143 -11.914 -7.386  1.00  24.84 ? 124  ILE B C   1 
ATOM   3236 O O   . ILE B 1 124 ? -10.105 -12.502 -6.997  1.00  25.10 ? 124  ILE B O   1 
ATOM   3237 C CB  . ILE B 1 124 ? -11.082 -11.310 -9.851  1.00  25.01 ? 124  ILE B CB  1 
ATOM   3238 C CG1 . ILE B 1 124 ? -10.754 -10.225 -10.909 1.00  24.79 ? 124  ILE B CG1 1 
ATOM   3239 C CG2 . ILE B 1 124 ? -12.432 -12.012 -10.170 1.00  23.87 ? 124  ILE B CG2 1 
ATOM   3240 C CD1 . ILE B 1 124 ? -11.763 -9.103  -11.030 1.00  27.61 ? 124  ILE B CD1 1 
ATOM   3241 N N   . ILE B 1 125 ? -12.379 -12.198 -6.955  1.00  24.60 ? 125  ILE B N   1 
ATOM   3242 C CA  . ILE B 1 125 ? -12.704 -13.381 -6.166  1.00  24.71 ? 125  ILE B CA  1 
ATOM   3243 C C   . ILE B 1 125 ? -13.888 -13.997 -6.885  1.00  25.72 ? 125  ILE B C   1 
ATOM   3244 O O   . ILE B 1 125 ? -14.983 -13.419 -6.917  1.00  26.15 ? 125  ILE B O   1 
ATOM   3245 C CB  . ILE B 1 125 ? -13.074 -13.022 -4.691  1.00  24.41 ? 125  ILE B CB  1 
ATOM   3246 C CG1 . ILE B 1 125 ? -11.873 -12.382 -3.967  1.00  23.97 ? 125  ILE B CG1 1 
ATOM   3247 C CG2 . ILE B 1 125 ? -13.547 -14.237 -3.929  1.00  22.99 ? 125  ILE B CG2 1 
ATOM   3248 C CD1 . ILE B 1 125 ? -12.186 -11.855 -2.571  1.00  24.53 ? 125  ILE B CD1 1 
ATOM   3249 N N   . THR B 1 126 ? -13.665 -15.145 -7.510  1.00  26.81 ? 126  THR B N   1 
ATOM   3250 C CA  . THR B 1 126 ? -14.715 -15.795 -8.284  1.00  27.89 ? 126  THR B CA  1 
ATOM   3251 C C   . THR B 1 126 ? -14.896 -17.253 -7.798  1.00  29.42 ? 126  THR B C   1 
ATOM   3252 O O   . THR B 1 126 ? -14.176 -17.707 -6.895  1.00  29.68 ? 126  THR B O   1 
ATOM   3253 C CB  . THR B 1 126 ? -14.434 -15.623 -9.803  1.00  27.47 ? 126  THR B CB  1 
ATOM   3254 O OG1 . THR B 1 126 ? -15.595 -15.932 -10.578 1.00  27.12 ? 126  THR B OG1 1 
ATOM   3255 C CG2 . THR B 1 126 ? -13.244 -16.469 -10.257 1.00  27.76 ? 126  THR B CG2 1 
ATOM   3256 N N   . MET B 1 127 ? -15.873 -17.969 -8.342  1.00  31.17 ? 127  MET B N   1 
ATOM   3257 C CA  . MET B 1 127 ? -16.122 -19.336 -7.904  1.00  33.24 ? 127  MET B CA  1 
ATOM   3258 C C   . MET B 1 127 ? -16.340 -20.300 -9.065  1.00  34.07 ? 127  MET B C   1 
ATOM   3259 O O   . MET B 1 127 ? -17.222 -20.094 -9.894  1.00  33.85 ? 127  MET B O   1 
ATOM   3260 C CB  . MET B 1 127 ? -17.305 -19.371 -6.924  1.00  33.88 ? 127  MET B CB  1 
ATOM   3261 C CG  . MET B 1 127 ? -17.709 -20.773 -6.418  1.00  36.27 ? 127  MET B CG  1 
ATOM   3262 S SD  . MET B 1 127 ? -18.578 -20.695 -4.824  1.00  41.07 ? 127  MET B SD  1 
ATOM   3263 C CE  . MET B 1 127 ? -17.252 -20.176 -3.740  1.00  36.97 ? 127  MET B CE  1 
ATOM   3264 N N   . ASP B 1 128 ? -15.522 -21.353 -9.091  1.00  35.62 ? 128  ASP B N   1 
ATOM   3265 C CA  . ASP B 1 128 ? -15.569 -22.426 -10.089 1.00  37.24 ? 128  ASP B CA  1 
ATOM   3266 C C   . ASP B 1 128 ? -15.575 -21.957 -11.549 1.00  38.07 ? 128  ASP B C   1 
ATOM   3267 O O   . ASP B 1 128 ? -16.491 -22.274 -12.303 1.00  38.43 ? 128  ASP B O   1 
ATOM   3268 C CB  . ASP B 1 128 ? -16.744 -23.371 -9.813  1.00  37.32 ? 128  ASP B CB  1 
ATOM   3269 C CG  . ASP B 1 128 ? -16.472 -24.323 -8.659  1.00  38.55 ? 128  ASP B CG  1 
ATOM   3270 O OD1 . ASP B 1 128 ? -15.352 -24.878 -8.582  1.00  38.81 ? 128  ASP B OD1 1 
ATOM   3271 O OD2 . ASP B 1 128 ? -17.392 -24.537 -7.833  1.00  41.05 ? 128  ASP B OD2 1 
ATOM   3272 N N   . LEU B 1 129 ? -14.548 -21.213 -11.943 1.00  39.37 ? 129  LEU B N   1 
ATOM   3273 C CA  . LEU B 1 129 ? -14.429 -20.724 -13.323 1.00  41.09 ? 129  LEU B CA  1 
ATOM   3274 C C   . LEU B 1 129 ? -14.633 -21.829 -14.346 1.00  42.36 ? 129  LEU B C   1 
ATOM   3275 O O   . LEU B 1 129 ? -14.058 -22.920 -14.202 1.00  42.66 ? 129  LEU B O   1 
ATOM   3276 C CB  . LEU B 1 129 ? -13.067 -20.072 -13.561 1.00  40.75 ? 129  LEU B CB  1 
ATOM   3277 C CG  . LEU B 1 129 ? -13.011 -18.569 -13.354 1.00  40.41 ? 129  LEU B CG  1 
ATOM   3278 C CD1 . LEU B 1 129 ? -11.568 -18.084 -13.439 1.00  41.86 ? 129  LEU B CD1 1 
ATOM   3279 C CD2 . LEU B 1 129 ? -13.879 -17.867 -14.370 1.00  39.84 ? 129  LEU B CD2 1 
ATOM   3280 N N   . HIS B 1 130 ? -15.438 -21.543 -15.375 1.00  43.78 ? 130  HIS B N   1 
ATOM   3281 C CA  . HIS B 1 130 ? -15.821 -22.563 -16.364 1.00  45.32 ? 130  HIS B CA  1 
ATOM   3282 C C   . HIS B 1 130 ? -14.590 -23.264 -16.915 1.00  45.88 ? 130  HIS B C   1 
ATOM   3283 O O   . HIS B 1 130 ? -14.616 -24.471 -17.186 1.00  46.31 ? 130  HIS B O   1 
ATOM   3284 C CB  . HIS B 1 130 ? -16.654 -21.956 -17.495 1.00  45.60 ? 130  HIS B CB  1 
ATOM   3285 C CG  . HIS B 1 130 ? -16.972 -22.920 -18.599 1.00  47.61 ? 130  HIS B CG  1 
ATOM   3286 N ND1 . HIS B 1 130 ? -17.943 -23.896 -18.487 1.00  49.69 ? 130  HIS B ND1 1 
ATOM   3287 C CD2 . HIS B 1 130 ? -16.442 -23.056 -19.838 1.00  48.42 ? 130  HIS B CD2 1 
ATOM   3288 C CE1 . HIS B 1 130 ? -18.003 -24.585 -19.614 1.00  50.06 ? 130  HIS B CE1 1 
ATOM   3289 N NE2 . HIS B 1 130 ? -17.101 -24.096 -20.449 1.00  49.62 ? 130  HIS B NE2 1 
ATOM   3290 N N   . ALA B 1 131 ? -13.521 -22.484 -17.080 1.00  46.38 ? 131  ALA B N   1 
ATOM   3291 C CA  . ALA B 1 131 ? -12.190 -23.004 -17.351 1.00  46.47 ? 131  ALA B CA  1 
ATOM   3292 C C   . ALA B 1 131 ? -11.242 -22.304 -16.389 1.00  46.53 ? 131  ALA B C   1 
ATOM   3293 O O   . ALA B 1 131 ? -11.311 -21.076 -16.246 1.00  46.96 ? 131  ALA B O   1 
ATOM   3294 C CB  . ALA B 1 131 ? -11.796 -22.713 -18.791 1.00  46.31 ? 131  ALA B CB  1 
ATOM   3295 N N   . SER B 1 132 ? -10.371 -23.074 -15.732 1.00  46.18 ? 132  SER B N   1 
ATOM   3296 C CA  . SER B 1 132 ? -9.331  -22.514 -14.847 1.00  45.80 ? 132  SER B CA  1 
ATOM   3297 C C   . SER B 1 132 ? -8.487  -21.472 -15.577 1.00  45.28 ? 132  SER B C   1 
ATOM   3298 O O   . SER B 1 132 ? -8.031  -20.497 -14.971 1.00  45.35 ? 132  SER B O   1 
ATOM   3299 C CB  . SER B 1 132 ? -8.396  -23.617 -14.343 1.00  45.83 ? 132  SER B CB  1 
ATOM   3300 O OG  . SER B 1 132 ? -9.114  -24.699 -13.776 1.00  47.31 ? 132  SER B OG  1 
ATOM   3301 N N   . GLN B 1 133 ? -8.299  -21.697 -16.881 1.00  44.53 ? 133  GLN B N   1 
ATOM   3302 C CA  . GLN B 1 133 ? -7.474  -20.853 -17.752 1.00  43.81 ? 133  GLN B CA  1 
ATOM   3303 C C   . GLN B 1 133 ? -7.919  -19.384 -17.788 1.00  42.72 ? 133  GLN B C   1 
ATOM   3304 O O   . GLN B 1 133 ? -7.182  -18.516 -18.240 1.00  42.70 ? 133  GLN B O   1 
ATOM   3305 C CB  . GLN B 1 133 ? -7.463  -21.413 -19.186 1.00  44.07 ? 133  GLN B CB  1 
ATOM   3306 C CG  . GLN B 1 133 ? -6.681  -22.722 -19.390 1.00  45.46 ? 133  GLN B CG  1 
ATOM   3307 C CD  . GLN B 1 133 ? -7.465  -24.000 -18.966 1.00  47.10 ? 133  GLN B CD  1 
ATOM   3308 O OE1 . GLN B 1 133 ? -8.702  -24.019 -18.915 1.00  46.69 ? 133  GLN B OE1 1 
ATOM   3309 N NE2 . GLN B 1 133 ? -6.731  -25.068 -18.656 1.00  47.30 ? 133  GLN B NE2 1 
ATOM   3310 N N   . ILE B 1 134 ? -9.125  -19.104 -17.317 1.00  41.40 ? 134  ILE B N   1 
ATOM   3311 C CA  . ILE B 1 134 ? -9.617  -17.735 -17.325 1.00  40.23 ? 134  ILE B CA  1 
ATOM   3312 C C   . ILE B 1 134 ? -8.792  -16.880 -16.350 1.00  39.14 ? 134  ILE B C   1 
ATOM   3313 O O   . ILE B 1 134 ? -8.632  -15.676 -16.558 1.00  39.43 ? 134  ILE B O   1 
ATOM   3314 C CB  . ILE B 1 134 ? -11.147 -17.681 -17.044 1.00  40.40 ? 134  ILE B CB  1 
ATOM   3315 C CG1 . ILE B 1 134 ? -11.916 -18.266 -18.232 1.00  40.54 ? 134  ILE B CG1 1 
ATOM   3316 C CG2 . ILE B 1 134 ? -11.627 -16.254 -16.743 1.00  40.66 ? 134  ILE B CG2 1 
ATOM   3317 C CD1 . ILE B 1 134 ? -13.287 -18.847 -17.862 1.00  41.60 ? 134  ILE B CD1 1 
ATOM   3318 N N   . GLN B 1 135 ? -8.247  -17.505 -15.305 1.00  37.20 ? 135  GLN B N   1 
ATOM   3319 C CA  . GLN B 1 135 ? -7.295  -16.822 -14.422 1.00  34.98 ? 135  GLN B CA  1 
ATOM   3320 C C   . GLN B 1 135 ? -6.130  -16.222 -15.191 1.00  32.80 ? 135  GLN B C   1 
ATOM   3321 O O   . GLN B 1 135 ? -5.539  -15.251 -14.744 1.00  32.40 ? 135  GLN B O   1 
ATOM   3322 C CB  . GLN B 1 135 ? -6.743  -17.776 -13.380 1.00  35.40 ? 135  GLN B CB  1 
ATOM   3323 C CG  . GLN B 1 135 ? -7.697  -18.085 -12.269 1.00  37.66 ? 135  GLN B CG  1 
ATOM   3324 C CD  . GLN B 1 135 ? -6.982  -18.540 -11.009 1.00  40.78 ? 135  GLN B CD  1 
ATOM   3325 O OE1 . GLN B 1 135 ? -6.035  -17.899 -10.539 1.00  42.14 ? 135  GLN B OE1 1 
ATOM   3326 N NE2 . GLN B 1 135 ? -7.441  -19.644 -10.447 1.00  41.34 ? 135  GLN B NE2 1 
ATOM   3327 N N   . GLY B 1 136 ? -5.799  -16.815 -16.339 1.00  30.61 ? 136  GLY B N   1 
ATOM   3328 C CA  . GLY B 1 136 ? -4.788  -16.269 -17.247 1.00  28.11 ? 136  GLY B CA  1 
ATOM   3329 C C   . GLY B 1 136 ? -5.298  -15.152 -18.154 1.00  26.47 ? 136  GLY B C   1 
ATOM   3330 O O   . GLY B 1 136 ? -4.579  -14.604 -18.975 1.00  26.22 ? 136  GLY B O   1 
ATOM   3331 N N   . PHE B 1 137 ? -6.553  -14.783 -18.012 1.00  25.20 ? 137  PHE B N   1 
ATOM   3332 C CA  . PHE B 1 137 ? -7.041  -13.656 -18.767 1.00  23.82 ? 137  PHE B CA  1 
ATOM   3333 C C   . PHE B 1 137 ? -6.789  -12.339 -18.043 1.00  23.26 ? 137  PHE B C   1 
ATOM   3334 O O   . PHE B 1 137 ? -7.007  -11.268 -18.598 1.00  23.97 ? 137  PHE B O   1 
ATOM   3335 C CB  . PHE B 1 137 ? -8.514  -13.836 -19.111 1.00  23.78 ? 137  PHE B CB  1 
ATOM   3336 C CG  . PHE B 1 137 ? -8.790  -14.995 -20.032 1.00  23.26 ? 137  PHE B CG  1 
ATOM   3337 C CD1 . PHE B 1 137 ? -10.081 -15.444 -20.214 1.00  23.97 ? 137  PHE B CD1 1 
ATOM   3338 C CD2 . PHE B 1 137 ? -7.760  -15.636 -20.712 1.00  23.04 ? 137  PHE B CD2 1 
ATOM   3339 C CE1 . PHE B 1 137 ? -10.342 -16.499 -21.070 1.00  25.20 ? 137  PHE B CE1 1 
ATOM   3340 C CE2 . PHE B 1 137 ? -8.004  -16.692 -21.553 1.00  22.17 ? 137  PHE B CE2 1 
ATOM   3341 C CZ  . PHE B 1 137 ? -9.295  -17.127 -21.742 1.00  24.16 ? 137  PHE B CZ  1 
ATOM   3342 N N   . PHE B 1 138 ? -6.308  -12.418 -16.806 1.00  22.26 ? 138  PHE B N   1 
ATOM   3343 C CA  . PHE B 1 138 ? -5.993  -11.232 -15.999 1.00  21.65 ? 138  PHE B CA  1 
ATOM   3344 C C   . PHE B 1 138 ? -4.504  -11.151 -15.765 1.00  21.06 ? 138  PHE B C   1 
ATOM   3345 O O   . PHE B 1 138 ? -3.798  -12.193 -15.929 1.00  21.55 ? 138  PHE B O   1 
ATOM   3346 C CB  . PHE B 1 138 ? -6.695  -11.304 -14.627 1.00  21.30 ? 138  PHE B CB  1 
ATOM   3347 C CG  . PHE B 1 138 ? -8.176  -11.283 -14.722 1.00  20.56 ? 138  PHE B CG  1 
ATOM   3348 C CD1 . PHE B 1 138 ? -8.894  -12.479 -14.793 1.00  21.14 ? 138  PHE B CD1 1 
ATOM   3349 C CD2 . PHE B 1 138 ? -8.874  -10.060 -14.809 1.00  19.41 ? 138  PHE B CD2 1 
ATOM   3350 C CE1 . PHE B 1 138 ? -10.270 -12.456 -14.909 1.00  19.68 ? 138  PHE B CE1 1 
ATOM   3351 C CE2 . PHE B 1 138 ? -10.251 -10.034 -14.928 1.00  19.08 ? 138  PHE B CE2 1 
ATOM   3352 C CZ  . PHE B 1 138 ? -10.945 -11.231 -14.976 1.00  19.23 ? 138  PHE B CZ  1 
ATOM   3353 N N   . ASP B 1 139 ? -4.022  -9.955  -15.367 0.50  20.64 ? 139  ASP B N   1 
ATOM   3354 C CA  . ASP B 1 139 ? -2.656  -9.883  -14.865 0.50  20.65 ? 139  ASP B CA  1 
ATOM   3355 C C   . ASP B 1 139 ? -2.642  -9.584  -13.381 0.50  20.40 ? 139  ASP B C   1 
ATOM   3356 O O   . ASP B 1 139 ? -1.604  -9.703  -12.740 0.50  20.47 ? 139  ASP B O   1 
ATOM   3357 C CB  . ASP B 1 139 ? -1.826  -8.849  -15.631 0.50  20.87 ? 139  ASP B CB  1 
ATOM   3358 C CG  . ASP B 1 139 ? -1.289  -9.397  -16.943 0.50  20.33 ? 139  ASP B CG  1 
ATOM   3359 O OD1 . ASP B 1 139 ? -0.612  -10.451 -16.955 0.50  19.06 ? 139  ASP B OD1 1 
ATOM   3360 O OD2 . ASP B 1 139 ? -1.553  -8.763  -17.980 0.50  21.88 ? 139  ASP B OD2 1 
ATOM   3361 N N   . ILE B 1 140 ? -3.803  -9.171  -12.870 1.00  20.26 ? 140  ILE B N   1 
ATOM   3362 C CA  . ILE B 1 140 ? -4.059  -9.007  -11.433 1.00  19.46 ? 140  ILE B CA  1 
ATOM   3363 C C   . ILE B 1 140 ? -4.242  -10.404 -10.862 1.00  20.09 ? 140  ILE B C   1 
ATOM   3364 O O   . ILE B 1 140 ? -4.400  -11.390 -11.653 1.00  20.45 ? 140  ILE B O   1 
ATOM   3365 C CB  . ILE B 1 140 ? -5.355  -8.136  -11.132 1.00  18.76 ? 140  ILE B CB  1 
ATOM   3366 C CG1 . ILE B 1 140 ? -6.644  -8.846  -11.637 1.00  18.15 ? 140  ILE B CG1 1 
ATOM   3367 C CG2 . ILE B 1 140 ? -5.174  -6.679  -11.611 1.00  16.94 ? 140  ILE B CG2 1 
ATOM   3368 C CD1 . ILE B 1 140 ? -7.966  -8.082  -11.437 1.00  16.87 ? 140  ILE B CD1 1 
ATOM   3369 N N   . PRO B 1 141 ? -4.181  -10.518 -9.509  1.00  20.49 ? 141  PRO B N   1 
ATOM   3370 C CA  . PRO B 1 141 ? -4.514  -11.762 -8.841  1.00  20.77 ? 141  PRO B CA  1 
ATOM   3371 C C   . PRO B 1 141 ? -6.000  -12.080 -9.015  1.00  21.29 ? 141  PRO B C   1 
ATOM   3372 O O   . PRO B 1 141 ? -6.880  -11.151 -8.884  1.00  22.03 ? 141  PRO B O   1 
ATOM   3373 C CB  . PRO B 1 141 ? -4.179  -11.479 -7.364  1.00  20.63 ? 141  PRO B CB  1 
ATOM   3374 C CG  . PRO B 1 141 ? -3.957  -10.022 -7.284  1.00  20.77 ? 141  PRO B CG  1 
ATOM   3375 C CD  . PRO B 1 141 ? -3.450  -9.616  -8.611  1.00  20.60 ? 141  PRO B CD  1 
ATOM   3376 N N   . VAL B 1 142 ? -6.234  -13.421 -8.951  1.00  22.31 ? 142  VAL B N   1 
ATOM   3377 C CA  . VAL B 1 142 ? -7.582  -13.991 -8.943  1.00  22.72 ? 142  VAL B CA  1 
ATOM   3378 C C   . VAL B 1 142 ? -7.602  -15.086 -7.876  1.00  22.64 ? 142  VAL B C   1 
ATOM   3379 O O   . VAL B 1 142 ? -6.760  -15.954 -7.859  1.00  22.11 ? 142  VAL B O   1 
ATOM   3380 C CB  . VAL B 1 142 ? -7.977  -14.593 -10.339 1.00  22.25 ? 142  VAL B CB  1 
ATOM   3381 C CG1 . VAL B 1 142 ? -9.288  -15.355 -10.246 1.00  22.44 ? 142  VAL B CG1 1 
ATOM   3382 C CG2 . VAL B 1 142 ? -8.080  -13.519 -11.368 1.00  21.17 ? 142  VAL B CG2 1 
ATOM   3383 N N   . ASP B 1 143 ? -8.540  -15.010 -6.953  1.00  23.85 ? 143  ASP B N   1 
ATOM   3384 C CA  . ASP B 1 143 ? -8.802  -16.145 -6.085  1.00  24.63 ? 143  ASP B CA  1 
ATOM   3385 C C   . ASP B 1 143 ? -10.016 -16.852 -6.672  1.00  25.68 ? 143  ASP B C   1 
ATOM   3386 O O   . ASP B 1 143 ? -11.138 -16.312 -6.664  1.00  25.94 ? 143  ASP B O   1 
ATOM   3387 C CB  . ASP B 1 143 ? -9.023  -15.686 -4.652  1.00  23.87 ? 143  ASP B CB  1 
ATOM   3388 C CG  . ASP B 1 143 ? -7.720  -15.201 -3.975  1.00  24.17 ? 143  ASP B CG  1 
ATOM   3389 O OD1 . ASP B 1 143 ? -6.613  -15.726 -4.265  1.00  24.57 ? 143  ASP B OD1 1 
ATOM   3390 O OD2 . ASP B 1 143 ? -7.794  -14.301 -3.113  1.00  23.47 ? 143  ASP B OD2 1 
ATOM   3391 N N   . ASN B 1 144 ? -9.765  -18.016 -7.274  1.00  26.56 ? 144  ASN B N   1 
ATOM   3392 C CA  . ASN B 1 144 ? -10.840 -18.833 -7.807  1.00  27.30 ? 144  ASN B CA  1 
ATOM   3393 C C   . ASN B 1 144 ? -11.175 -19.920 -6.822  1.00  28.12 ? 144  ASN B C   1 
ATOM   3394 O O   . ASN B 1 144 ? -10.380 -20.827 -6.579  1.00  28.33 ? 144  ASN B O   1 
ATOM   3395 C CB  . ASN B 1 144 ? -10.493 -19.442 -9.158  1.00  27.10 ? 144  ASN B CB  1 
ATOM   3396 C CG  . ASN B 1 144 ? -11.636 -20.254 -9.731  1.00  26.37 ? 144  ASN B CG  1 
ATOM   3397 O OD1 . ASN B 1 144 ? -12.736 -19.727 -9.973  1.00  24.86 ? 144  ASN B OD1 1 
ATOM   3398 N ND2 . ASN B 1 144 ? -11.386 -21.535 -9.951  1.00  26.61 ? 144  ASN B ND2 1 
ATOM   3399 N N   . LEU B 1 145 ? -12.367 -19.795 -6.259  1.00  29.28 ? 145  LEU B N   1 
ATOM   3400 C CA  . LEU B 1 145 ? -12.839 -20.667 -5.209  1.00  30.24 ? 145  LEU B CA  1 
ATOM   3401 C C   . LEU B 1 145 ? -13.527 -21.892 -5.802  1.00  30.87 ? 145  LEU B C   1 
ATOM   3402 O O   . LEU B 1 145 ? -13.984 -21.863 -6.953  1.00  31.03 ? 145  LEU B O   1 
ATOM   3403 C CB  . LEU B 1 145 ? -13.796 -19.889 -4.310  1.00  30.09 ? 145  LEU B CB  1 
ATOM   3404 C CG  . LEU B 1 145 ? -13.240 -18.615 -3.673  1.00  29.60 ? 145  LEU B CG  1 
ATOM   3405 C CD1 . LEU B 1 145 ? -14.240 -18.071 -2.660  1.00  29.10 ? 145  LEU B CD1 1 
ATOM   3406 C CD2 . LEU B 1 145 ? -11.914 -18.904 -2.996  1.00  30.08 ? 145  LEU B CD2 1 
ATOM   3407 N N   . TYR B 1 146 ? -13.577 -22.963 -5.018  0.60  31.22 ? 146  TYR B N   1 
ATOM   3408 C CA  . TYR B 1 146 ? -14.252 -24.168 -5.436  0.60  31.71 ? 146  TYR B CA  1 
ATOM   3409 C C   . TYR B 1 146 ? -15.420 -24.449 -4.531  0.60  32.21 ? 146  TYR B C   1 
ATOM   3410 O O   . TYR B 1 146 ? -15.358 -24.201 -3.316  0.60  32.17 ? 146  TYR B O   1 
ATOM   3411 C CB  . TYR B 1 146 ? -13.293 -25.343 -5.395  0.60  31.75 ? 146  TYR B CB  1 
ATOM   3412 C CG  . TYR B 1 146 ? -12.061 -25.121 -6.211  0.60  32.15 ? 146  TYR B CG  1 
ATOM   3413 C CD1 . TYR B 1 146 ? -10.916 -24.593 -5.629  0.60  33.39 ? 146  TYR B CD1 1 
ATOM   3414 C CD2 . TYR B 1 146 ? -12.034 -25.436 -7.569  0.60  32.80 ? 146  TYR B CD2 1 
ATOM   3415 C CE1 . TYR B 1 146 ? -9.772  -24.383 -6.369  0.60  33.95 ? 146  TYR B CE1 1 
ATOM   3416 C CE2 . TYR B 1 146 ? -10.894 -25.231 -8.324  0.60  33.43 ? 146  TYR B CE2 1 
ATOM   3417 C CZ  . TYR B 1 146 ? -9.767  -24.705 -7.711  0.60  34.34 ? 146  TYR B CZ  1 
ATOM   3418 O OH  . TYR B 1 146 ? -8.620  -24.492 -8.429  0.60  36.41 ? 146  TYR B OH  1 
ATOM   3419 N N   . ALA B 1 147 ? -16.486 -24.969 -5.126  1.00  32.93 ? 147  ALA B N   1 
ATOM   3420 C CA  . ALA B 1 147 ? -17.600 -25.480 -4.337  1.00  33.83 ? 147  ALA B CA  1 
ATOM   3421 C C   . ALA B 1 147 ? -17.424 -26.969 -4.093  1.00  34.47 ? 147  ALA B C   1 
ATOM   3422 O O   . ALA B 1 147 ? -18.167 -27.558 -3.302  1.00  34.60 ? 147  ALA B O   1 
ATOM   3423 C CB  . ALA B 1 147 ? -18.933 -25.185 -4.993  1.00  33.90 ? 147  ALA B CB  1 
ATOM   3424 N N   . GLU B 1 148 ? -16.422 -27.567 -4.744  1.00  35.28 ? 148  GLU B N   1 
ATOM   3425 C CA  . GLU B 1 148 ? -16.071 -28.969 -4.500  1.00  36.42 ? 148  GLU B CA  1 
ATOM   3426 C C   . GLU B 1 148 ? -16.228 -29.331 -3.016  1.00  36.91 ? 148  GLU B C   1 
ATOM   3427 O O   . GLU B 1 148 ? -17.047 -30.197 -2.684  1.00  37.06 ? 148  GLU B O   1 
ATOM   3428 C CB  . GLU B 1 148 ? -14.666 -29.303 -5.022  1.00  36.45 ? 148  GLU B CB  1 
ATOM   3429 C CG  . GLU B 1 148 ? -14.168 -30.729 -4.704  1.00  38.38 ? 148  GLU B CG  1 
ATOM   3430 C CD  . GLU B 1 148 ? -13.121 -31.255 -5.715  1.00  41.05 ? 148  GLU B CD  1 
ATOM   3431 O OE1 . GLU B 1 148 ? -12.774 -30.520 -6.663  1.00  41.72 ? 148  GLU B OE1 1 
ATOM   3432 O OE2 . GLU B 1 148 ? -12.651 -32.412 -5.578  1.00  41.71 ? 148  GLU B OE2 1 
ATOM   3433 N N   . PRO B 1 149 ? -15.489 -28.644 -2.115  1.00  37.43 ? 149  PRO B N   1 
ATOM   3434 C CA  . PRO B 1 149 ? -15.625 -29.046 -0.715  1.00  37.68 ? 149  PRO B CA  1 
ATOM   3435 C C   . PRO B 1 149 ? -17.091 -29.130 -0.288  1.00  37.95 ? 149  PRO B C   1 
ATOM   3436 O O   . PRO B 1 149 ? -17.523 -30.187 0.183   1.00  38.39 ? 149  PRO B O   1 
ATOM   3437 C CB  . PRO B 1 149 ? -14.881 -27.940 0.050   1.00  37.81 ? 149  PRO B CB  1 
ATOM   3438 C CG  . PRO B 1 149 ? -13.870 -27.428 -0.923  1.00  37.77 ? 149  PRO B CG  1 
ATOM   3439 C CD  . PRO B 1 149 ? -14.545 -27.514 -2.275  1.00  37.44 ? 149  PRO B CD  1 
ATOM   3440 N N   . ALA B 1 150 ? -17.849 -28.048 -0.483  1.00  37.87 ? 150  ALA B N   1 
ATOM   3441 C CA  . ALA B 1 150 ? -19.287 -28.036 -0.164  1.00  37.89 ? 150  ALA B CA  1 
ATOM   3442 C C   . ALA B 1 150 ? -20.063 -29.177 -0.853  1.00  38.02 ? 150  ALA B C   1 
ATOM   3443 O O   . ALA B 1 150 ? -20.911 -29.821 -0.236  1.00  37.99 ? 150  ALA B O   1 
ATOM   3444 C CB  . ALA B 1 150 ? -19.903 -26.688 -0.521  1.00  37.66 ? 150  ALA B CB  1 
ATOM   3445 N N   . VAL B 1 151 ? -19.763 -29.422 -2.128  1.00  38.03 ? 151  VAL B N   1 
ATOM   3446 C CA  . VAL B 1 151 ? -20.427 -30.480 -2.873  1.00  38.40 ? 151  VAL B CA  1 
ATOM   3447 C C   . VAL B 1 151 ? -20.153 -31.841 -2.240  1.00  38.63 ? 151  VAL B C   1 
ATOM   3448 O O   . VAL B 1 151 ? -21.092 -32.601 -1.964  1.00  38.93 ? 151  VAL B O   1 
ATOM   3449 C CB  . VAL B 1 151 ? -20.038 -30.475 -4.361  1.00  38.34 ? 151  VAL B CB  1 
ATOM   3450 C CG1 . VAL B 1 151 ? -20.568 -31.716 -5.044  1.00  38.02 ? 151  VAL B CG1 1 
ATOM   3451 C CG2 . VAL B 1 151 ? -20.611 -29.237 -5.042  1.00  38.78 ? 151  VAL B CG2 1 
ATOM   3452 N N   . LEU B 1 152 ? -18.877 -32.130 -1.996  1.00  38.52 ? 152  LEU B N   1 
ATOM   3453 C CA  . LEU B 1 152 ? -18.484 -33.326 -1.264  1.00  38.46 ? 152  LEU B CA  1 
ATOM   3454 C C   . LEU B 1 152 ? -19.295 -33.459 0.048   1.00  38.48 ? 152  LEU B C   1 
ATOM   3455 O O   . LEU B 1 152 ? -19.891 -34.498 0.321   1.00  38.54 ? 152  LEU B O   1 
ATOM   3456 C CB  . LEU B 1 152 ? -16.969 -33.304 -0.994  1.00  38.45 ? 152  LEU B CB  1 
ATOM   3457 C CG  . LEU B 1 152 ? -16.044 -33.353 -2.216  1.00  38.76 ? 152  LEU B CG  1 
ATOM   3458 C CD1 . LEU B 1 152 ? -14.633 -32.928 -1.891  1.00  39.52 ? 152  LEU B CD1 1 
ATOM   3459 C CD2 . LEU B 1 152 ? -16.026 -34.729 -2.805  1.00  39.73 ? 152  LEU B CD2 1 
ATOM   3460 N N   . LYS B 1 153 ? -19.333 -32.390 0.834   1.00  38.28 ? 153  LYS B N   1 
ATOM   3461 C CA  . LYS B 1 153 ? -20.056 -32.366 2.093   1.00  38.58 ? 153  LYS B CA  1 
ATOM   3462 C C   . LYS B 1 153 ? -21.555 -32.587 1.904   1.00  38.83 ? 153  LYS B C   1 
ATOM   3463 O O   . LYS B 1 153 ? -22.209 -33.232 2.732   1.00  39.29 ? 153  LYS B O   1 
ATOM   3464 C CB  . LYS B 1 153 ? -19.827 -31.017 2.785   1.00  38.75 ? 153  LYS B CB  1 
ATOM   3465 C CG  . LYS B 1 153 ? -20.732 -30.738 3.983   1.00  38.73 ? 153  LYS B CG  1 
ATOM   3466 C CD  . LYS B 1 153 ? -20.154 -29.633 4.845   1.00  39.58 ? 153  LYS B CD  1 
ATOM   3467 C CE  . LYS B 1 153 ? -20.552 -29.815 6.308   1.00  40.70 ? 153  LYS B CE  1 
ATOM   3468 N NZ  . LYS B 1 153 ? -21.926 -29.299 6.573   1.00  41.43 ? 153  LYS B NZ  1 
ATOM   3469 N N   . TRP B 1 154 ? -22.102 -32.033 0.831   1.00  38.77 ? 154  TRP B N   1 
ATOM   3470 C CA  . TRP B 1 154 ? -23.504 -32.234 0.532   1.00  38.62 ? 154  TRP B CA  1 
ATOM   3471 C C   . TRP B 1 154 ? -23.739 -33.703 0.176   1.00  38.72 ? 154  TRP B C   1 
ATOM   3472 O O   . TRP B 1 154 ? -24.660 -34.326 0.704   1.00  38.50 ? 154  TRP B O   1 
ATOM   3473 C CB  . TRP B 1 154 ? -24.000 -31.285 -0.580  1.00  38.50 ? 154  TRP B CB  1 
ATOM   3474 C CG  . TRP B 1 154 ? -25.480 -31.388 -0.755  1.00  38.12 ? 154  TRP B CG  1 
ATOM   3475 C CD1 . TRP B 1 154 ? -26.434 -30.616 -0.159  1.00  37.90 ? 154  TRP B CD1 1 
ATOM   3476 C CD2 . TRP B 1 154 ? -26.183 -32.365 -1.534  1.00  38.29 ? 154  TRP B CD2 1 
ATOM   3477 N NE1 . TRP B 1 154 ? -27.690 -31.034 -0.539  1.00  38.08 ? 154  TRP B NE1 1 
ATOM   3478 C CE2 . TRP B 1 154 ? -27.562 -32.110 -1.378  1.00  38.59 ? 154  TRP B CE2 1 
ATOM   3479 C CE3 . TRP B 1 154 ? -25.779 -33.426 -2.355  1.00  38.36 ? 154  TRP B CE3 1 
ATOM   3480 C CZ2 . TRP B 1 154 ? -28.542 -32.884 -2.007  1.00  39.68 ? 154  TRP B CZ2 1 
ATOM   3481 C CZ3 . TRP B 1 154 ? -26.752 -34.184 -2.987  1.00  39.33 ? 154  TRP B CZ3 1 
ATOM   3482 C CH2 . TRP B 1 154 ? -28.118 -33.913 -2.807  1.00  39.01 ? 154  TRP B CH2 1 
ATOM   3483 N N   . ILE B 1 155 ? -22.907 -34.247 -0.711  1.00  39.01 ? 155  ILE B N   1 
ATOM   3484 C CA  . ILE B 1 155 ? -23.034 -35.651 -1.103  1.00  39.54 ? 155  ILE B CA  1 
ATOM   3485 C C   . ILE B 1 155 ? -22.969 -36.529 0.145   1.00  39.85 ? 155  ILE B C   1 
ATOM   3486 O O   . ILE B 1 155 ? -23.981 -37.135 0.525   1.00  40.38 ? 155  ILE B O   1 
ATOM   3487 C CB  . ILE B 1 155 ? -21.981 -36.093 -2.156  1.00  39.39 ? 155  ILE B CB  1 
ATOM   3488 C CG1 . ILE B 1 155 ? -22.117 -35.264 -3.429  1.00  39.68 ? 155  ILE B CG1 1 
ATOM   3489 C CG2 . ILE B 1 155 ? -22.165 -37.553 -2.504  1.00  39.24 ? 155  ILE B CG2 1 
ATOM   3490 C CD1 . ILE B 1 155 ? -20.952 -35.416 -4.395  1.00  39.34 ? 155  ILE B CD1 1 
ATOM   3491 N N   . ARG B 1 156 ? -21.807 -36.562 0.798   1.00  39.84 ? 156  ARG B N   1 
ATOM   3492 C CA  . ARG B 1 156 ? -21.618 -37.396 1.986   1.00  40.38 ? 156  ARG B CA  1 
ATOM   3493 C C   . ARG B 1 156 ? -22.859 -37.442 2.895   1.00  40.47 ? 156  ARG B C   1 
ATOM   3494 O O   . ARG B 1 156 ? -23.291 -38.528 3.303   1.00  40.74 ? 156  ARG B O   1 
ATOM   3495 C CB  . ARG B 1 156 ? -20.358 -37.000 2.785   1.00  40.49 ? 156  ARG B CB  1 
ATOM   3496 C CG  . ARG B 1 156 ? -19.041 -37.444 2.153   1.00  41.47 ? 156  ARG B CG  1 
ATOM   3497 C CD  . ARG B 1 156 ? -17.867 -37.364 3.119   1.00  43.18 ? 156  ARG B CD  1 
ATOM   3498 N NE  . ARG B 1 156 ? -16.653 -37.905 2.507   1.00  47.14 ? 156  ARG B NE  1 
ATOM   3499 C CZ  . ARG B 1 156 ? -15.758 -37.187 1.819   1.00  48.59 ? 156  ARG B CZ  1 
ATOM   3500 N NH1 . ARG B 1 156 ? -15.934 -35.874 1.665   1.00  48.53 ? 156  ARG B NH1 1 
ATOM   3501 N NH2 . ARG B 1 156 ? -14.690 -37.785 1.279   1.00  47.08 ? 156  ARG B NH2 1 
ATOM   3502 N N   . GLU B 1 157 ? -23.456 -36.283 3.168   0.40  40.41 ? 157  GLU B N   1 
ATOM   3503 C CA  . GLU B 1 157 ? -24.518 -36.190 4.169   0.40  40.45 ? 157  GLU B CA  1 
ATOM   3504 C C   . GLU B 1 157 ? -25.955 -36.318 3.657   0.40  40.65 ? 157  GLU B C   1 
ATOM   3505 O O   . GLU B 1 157 ? -26.886 -36.270 4.454   0.40  40.64 ? 157  GLU B O   1 
ATOM   3506 C CB  . GLU B 1 157 ? -24.377 -34.897 4.971   0.40  40.41 ? 157  GLU B CB  1 
ATOM   3507 C CG  . GLU B 1 157 ? -25.037 -33.686 4.333   0.40  40.23 ? 157  GLU B CG  1 
ATOM   3508 C CD  . GLU B 1 157 ? -24.621 -32.378 4.994   0.40  39.71 ? 157  GLU B CD  1 
ATOM   3509 O OE1 . GLU B 1 157 ? -25.305 -31.347 4.793   0.40  38.62 ? 157  GLU B OE1 1 
ATOM   3510 O OE2 . GLU B 1 157 ? -23.606 -32.384 5.724   0.40  39.55 ? 157  GLU B OE2 1 
ATOM   3511 N N   . ASN B 1 158 ? -26.145 -36.481 2.349   1.00  41.03 ? 158  ASN B N   1 
ATOM   3512 C CA  . ASN B 1 158 ? -27.502 -36.637 1.787   1.00  41.46 ? 158  ASN B CA  1 
ATOM   3513 C C   . ASN B 1 158 ? -27.707 -37.847 0.873   1.00  41.61 ? 158  ASN B C   1 
ATOM   3514 O O   . ASN B 1 158 ? -28.855 -38.222 0.580   1.00  41.68 ? 158  ASN B O   1 
ATOM   3515 C CB  . ASN B 1 158 ? -27.938 -35.385 1.019   1.00  41.69 ? 158  ASN B CB  1 
ATOM   3516 C CG  . ASN B 1 158 ? -27.938 -34.144 1.873   1.00  42.21 ? 158  ASN B CG  1 
ATOM   3517 O OD1 . ASN B 1 158 ? -28.857 -33.907 2.642   1.00  43.08 ? 158  ASN B OD1 1 
ATOM   3518 N ND2 . ASN B 1 158 ? -26.903 -33.332 1.732   1.00  43.38 ? 158  ASN B ND2 1 
ATOM   3519 N N   . ILE B 1 159 ? -26.612 -38.427 0.386   1.00  41.53 ? 159  ILE B N   1 
ATOM   3520 C CA  . ILE B 1 159 ? -26.730 -39.545 -0.548  1.00  41.63 ? 159  ILE B CA  1 
ATOM   3521 C C   . ILE B 1 159 ? -26.154 -40.790 0.101   1.00  41.86 ? 159  ILE B C   1 
ATOM   3522 O O   . ILE B 1 159 ? -24.925 -40.962 0.181   1.00  42.39 ? 159  ILE B O   1 
ATOM   3523 C CB  . ILE B 1 159 ? -26.131 -39.208 -1.950  1.00  41.59 ? 159  ILE B CB  1 
ATOM   3524 C CG1 . ILE B 1 159 ? -26.953 -38.090 -2.597  1.00  40.88 ? 159  ILE B CG1 1 
ATOM   3525 C CG2 . ILE B 1 159 ? -26.110 -40.431 -2.879  1.00  41.06 ? 159  ILE B CG2 1 
ATOM   3526 C CD1 . ILE B 1 159 ? -26.250 -37.375 -3.718  1.00  41.70 ? 159  ILE B CD1 1 
ATOM   3527 N N   . SER B 1 160 ? -27.066 -41.645 0.566   1.00  41.85 ? 160  SER B N   1 
ATOM   3528 C CA  . SER B 1 160 ? -26.744 -42.769 1.447   1.00  41.63 ? 160  SER B CA  1 
ATOM   3529 C C   . SER B 1 160 ? -25.710 -43.666 0.808   1.00  41.26 ? 160  SER B C   1 
ATOM   3530 O O   . SER B 1 160 ? -24.813 -44.178 1.484   1.00  41.06 ? 160  SER B O   1 
ATOM   3531 C CB  . SER B 1 160 ? -28.022 -43.552 1.762   1.00  41.83 ? 160  SER B CB  1 
ATOM   3532 O OG  . SER B 1 160 ? -29.104 -42.664 2.057   1.00  42.20 ? 160  SER B OG  1 
ATOM   3533 N N   . GLU B 1 161 ? -25.827 -43.796 -0.514  1.00  41.13 ? 161  GLU B N   1 
ATOM   3534 C CA  . GLU B 1 161 ? -25.012 -44.704 -1.308  1.00  40.92 ? 161  GLU B CA  1 
ATOM   3535 C C   . GLU B 1 161 ? -23.736 -44.059 -1.827  1.00  40.35 ? 161  GLU B C   1 
ATOM   3536 O O   . GLU B 1 161 ? -23.080 -44.619 -2.708  1.00  40.66 ? 161  GLU B O   1 
ATOM   3537 C CB  . GLU B 1 161 ? -25.813 -45.246 -2.498  1.00  41.10 ? 161  GLU B CB  1 
ATOM   3538 C CG  . GLU B 1 161 ? -27.010 -46.129 -2.154  1.00  42.64 ? 161  GLU B CG  1 
ATOM   3539 C CD  . GLU B 1 161 ? -28.308 -45.336 -2.025  1.00  45.26 ? 161  GLU B CD  1 
ATOM   3540 O OE1 . GLU B 1 161 ? -28.243 -44.078 -1.925  1.00  45.59 ? 161  GLU B OE1 1 
ATOM   3541 O OE2 . GLU B 1 161 ? -29.392 -45.979 -2.023  1.00  45.85 ? 161  GLU B OE2 1 
ATOM   3542 N N   . TRP B 1 162 ? -23.371 -42.899 -1.288  1.00  39.69 ? 162  TRP B N   1 
ATOM   3543 C CA  . TRP B 1 162 ? -22.239 -42.135 -1.841  1.00  39.31 ? 162  TRP B CA  1 
ATOM   3544 C C   . TRP B 1 162 ? -20.928 -42.904 -1.916  1.00  39.53 ? 162  TRP B C   1 
ATOM   3545 O O   . TRP B 1 162 ? -20.043 -42.538 -2.679  1.00  39.64 ? 162  TRP B O   1 
ATOM   3546 C CB  . TRP B 1 162 ? -22.029 -40.789 -1.125  1.00  39.05 ? 162  TRP B CB  1 
ATOM   3547 C CG  . TRP B 1 162 ? -21.393 -40.804 0.251   1.00  36.92 ? 162  TRP B CG  1 
ATOM   3548 C CD1 . TRP B 1 162 ? -22.032 -40.605 1.428   1.00  34.80 ? 162  TRP B CD1 1 
ATOM   3549 C CD2 . TRP B 1 162 ? -20.000 -40.965 0.573   1.00  36.17 ? 162  TRP B CD2 1 
ATOM   3550 N NE1 . TRP B 1 162 ? -21.145 -40.647 2.467   1.00  35.33 ? 162  TRP B NE1 1 
ATOM   3551 C CE2 . TRP B 1 162 ? -19.887 -40.871 1.976   1.00  36.45 ? 162  TRP B CE2 1 
ATOM   3552 C CE3 . TRP B 1 162 ? -18.840 -41.187 -0.184  1.00  36.52 ? 162  TRP B CE3 1 
ATOM   3553 C CZ2 . TRP B 1 162 ? -18.656 -40.999 2.647   1.00  36.45 ? 162  TRP B CZ2 1 
ATOM   3554 C CZ3 . TRP B 1 162 ? -17.612 -41.308 0.484   1.00  36.09 ? 162  TRP B CZ3 1 
ATOM   3555 C CH2 . TRP B 1 162 ? -17.535 -41.209 1.883   1.00  36.10 ? 162  TRP B CH2 1 
ATOM   3556 N N   . ARG B 1 163 ? -20.812 -43.958 -1.116  1.00  39.67 ? 163  ARG B N   1 
ATOM   3557 C CA  . ARG B 1 163 ? -19.642 -44.808 -1.132  1.00  39.67 ? 163  ARG B CA  1 
ATOM   3558 C C   . ARG B 1 163 ? -19.616 -45.687 -2.381  1.00  39.56 ? 163  ARG B C   1 
ATOM   3559 O O   . ARG B 1 163 ? -18.552 -46.071 -2.865  1.00  39.45 ? 163  ARG B O   1 
ATOM   3560 C CB  . ARG B 1 163 ? -19.583 -45.622 0.157   1.00  39.73 ? 163  ARG B CB  1 
ATOM   3561 C CG  . ARG B 1 163 ? -19.326 -44.733 1.366   1.00  40.30 ? 163  ARG B CG  1 
ATOM   3562 C CD  . ARG B 1 163 ? -18.945 -45.538 2.584   1.00  41.69 ? 163  ARG B CD  1 
ATOM   3563 N NE  . ARG B 1 163 ? -18.558 -44.696 3.712   1.00  41.99 ? 163  ARG B NE  1 
ATOM   3564 C CZ  . ARG B 1 163 ? -19.406 -44.039 4.511   1.00  43.49 ? 163  ARG B CZ  1 
ATOM   3565 N NH1 . ARG B 1 163 ? -20.726 -44.087 4.311   1.00  42.42 ? 163  ARG B NH1 1 
ATOM   3566 N NH2 . ARG B 1 163 ? -18.924 -43.318 5.526   1.00  43.79 ? 163  ARG B NH2 1 
ATOM   3567 N N   . ASN B 1 164 ? -20.792 -45.963 -2.923  1.00  39.66 ? 164  ASN B N   1 
ATOM   3568 C CA  . ASN B 1 164 ? -20.884 -46.791 -4.116  1.00  39.95 ? 164  ASN B CA  1 
ATOM   3569 C C   . ASN B 1 164 ? -21.337 -46.110 -5.402  1.00  39.43 ? 164  ASN B C   1 
ATOM   3570 O O   . ASN B 1 164 ? -21.574 -46.783 -6.408  1.00  39.81 ? 164  ASN B O   1 
ATOM   3571 C CB  . ASN B 1 164 ? -21.708 -48.034 -3.824  1.00  40.10 ? 164  ASN B CB  1 
ATOM   3572 C CG  . ASN B 1 164 ? -20.928 -49.032 -3.034  1.00  40.87 ? 164  ASN B CG  1 
ATOM   3573 O OD1 . ASN B 1 164 ? -20.492 -50.056 -3.576  1.00  42.48 ? 164  ASN B OD1 1 
ATOM   3574 N ND2 . ASN B 1 164 ? -20.679 -48.716 -1.759  1.00  40.04 ? 164  ASN B ND2 1 
ATOM   3575 N N   . CYS B 1 165 ? -21.397 -44.783 -5.381  1.00  38.60 ? 165  CYS B N   1 
ATOM   3576 C CA  . CYS B 1 165 ? -21.954 -44.032 -6.502  1.00  38.06 ? 165  CYS B CA  1 
ATOM   3577 C C   . CYS B 1 165 ? -21.025 -43.845 -7.714  1.00  37.41 ? 165  CYS B C   1 
ATOM   3578 O O   . CYS B 1 165 ? -19.915 -44.378 -7.762  1.00  37.51 ? 165  CYS B O   1 
ATOM   3579 C CB  . CYS B 1 165 ? -22.533 -42.697 -6.021  1.00  38.06 ? 165  CYS B CB  1 
ATOM   3580 S SG  . CYS B 1 165 ? -21.324 -41.403 -5.672  1.00  38.36 ? 165  CYS B SG  1 
ATOM   3581 N N   . THR B 1 166 ? -21.513 -43.091 -8.694  1.00  36.69 ? 166  THR B N   1 
ATOM   3582 C CA  . THR B 1 166 ? -20.797 -42.830 -9.936  1.00  35.91 ? 166  THR B CA  1 
ATOM   3583 C C   . THR B 1 166 ? -20.957 -41.358 -10.282 1.00  35.41 ? 166  THR B C   1 
ATOM   3584 O O   . THR B 1 166 ? -22.071 -40.874 -10.499 1.00  34.85 ? 166  THR B O   1 
ATOM   3585 C CB  . THR B 1 166 ? -21.312 -43.712 -11.106 1.00  35.79 ? 166  THR B CB  1 
ATOM   3586 O OG1 . THR B 1 166 ? -20.952 -45.073 -10.862 1.00  36.12 ? 166  THR B OG1 1 
ATOM   3587 C CG2 . THR B 1 166 ? -20.678 -43.295 -12.419 1.00  35.61 ? 166  THR B CG2 1 
ATOM   3588 N N   . ILE B 1 167 ? -19.829 -40.650 -10.311 1.00  35.03 ? 167  ILE B N   1 
ATOM   3589 C CA  . ILE B 1 167 ? -19.811 -39.216 -10.578 1.00  34.20 ? 167  ILE B CA  1 
ATOM   3590 C C   . ILE B 1 167 ? -19.660 -39.003 -12.071 1.00  34.10 ? 167  ILE B C   1 
ATOM   3591 O O   . ILE B 1 167 ? -18.720 -39.505 -12.689 1.00  34.56 ? 167  ILE B O   1 
ATOM   3592 C CB  . ILE B 1 167 ? -18.706 -38.495 -9.767  1.00  34.04 ? 167  ILE B CB  1 
ATOM   3593 C CG1 . ILE B 1 167 ? -18.825 -38.825 -8.262  1.00  32.37 ? 167  ILE B CG1 1 
ATOM   3594 C CG2 . ILE B 1 167 ? -18.740 -36.975 -10.012 1.00  34.31 ? 167  ILE B CG2 1 
ATOM   3595 C CD1 . ILE B 1 167 ? -20.062 -38.282 -7.580  1.00  30.28 ? 167  ILE B CD1 1 
ATOM   3596 N N   . VAL B 1 168 ? -20.611 -38.283 -12.651 1.00  33.76 ? 168  VAL B N   1 
ATOM   3597 C CA  . VAL B 1 168 ? -20.747 -38.267 -14.097 1.00  33.78 ? 168  VAL B CA  1 
ATOM   3598 C C   . VAL B 1 168 ? -20.528 -36.879 -14.694 1.00  34.08 ? 168  VAL B C   1 
ATOM   3599 O O   . VAL B 1 168 ? -20.896 -35.849 -14.102 1.00  34.15 ? 168  VAL B O   1 
ATOM   3600 C CB  . VAL B 1 168 ? -22.108 -38.837 -14.546 1.00  33.52 ? 168  VAL B CB  1 
ATOM   3601 C CG1 . VAL B 1 168 ? -22.079 -39.160 -16.015 1.00  33.66 ? 168  VAL B CG1 1 
ATOM   3602 C CG2 . VAL B 1 168 ? -22.448 -40.088 -13.762 1.00  33.16 ? 168  VAL B CG2 1 
ATOM   3603 N N   . SER B 1 169 ? -19.903 -36.851 -15.864 1.00  34.13 ? 169  SER B N   1 
ATOM   3604 C CA  . SER B 1 169 ? -19.800 -35.612 -16.594 1.00  34.12 ? 169  SER B CA  1 
ATOM   3605 C C   . SER B 1 169 ? -20.821 -35.651 -17.689 1.00  34.28 ? 169  SER B C   1 
ATOM   3606 O O   . SER B 1 169 ? -20.904 -36.639 -18.419 1.00  34.25 ? 169  SER B O   1 
ATOM   3607 C CB  . SER B 1 169 ? -18.410 -35.402 -17.181 1.00  34.32 ? 169  SER B CB  1 
ATOM   3608 O OG  . SER B 1 169 ? -18.333 -34.108 -17.761 1.00  33.52 ? 169  SER B OG  1 
ATOM   3609 N N   . PRO B 1 170 ? -21.625 -34.584 -17.786 1.00  34.57 ? 170  PRO B N   1 
ATOM   3610 C CA  . PRO B 1 170 ? -22.600 -34.376 -18.850 1.00  34.90 ? 170  PRO B CA  1 
ATOM   3611 C C   . PRO B 1 170 ? -21.957 -33.985 -20.186 1.00  35.27 ? 170  PRO B C   1 
ATOM   3612 O O   . PRO B 1 170 ? -22.651 -33.925 -21.200 1.00  35.39 ? 170  PRO B O   1 
ATOM   3613 C CB  . PRO B 1 170 ? -23.468 -33.233 -18.312 1.00  34.82 ? 170  PRO B CB  1 
ATOM   3614 C CG  . PRO B 1 170 ? -22.620 -32.520 -17.357 1.00  34.56 ? 170  PRO B CG  1 
ATOM   3615 C CD  . PRO B 1 170 ? -21.743 -33.562 -16.733 1.00  34.59 ? 170  PRO B CD  1 
ATOM   3616 N N   . ASP B 1 171 ? -20.653 -33.703 -20.179 1.00  35.76 ? 171  ASP B N   1 
ATOM   3617 C CA  . ASP B 1 171 ? -19.897 -33.456 -21.413 1.00  36.37 ? 171  ASP B CA  1 
ATOM   3618 C C   . ASP B 1 171 ? -18.436 -33.878 -21.316 1.00  36.35 ? 171  ASP B C   1 
ATOM   3619 O O   . ASP B 1 171 ? -17.967 -34.277 -20.256 1.00  36.47 ? 171  ASP B O   1 
ATOM   3620 C CB  . ASP B 1 171 ? -20.044 -32.009 -21.909 1.00  36.84 ? 171  ASP B CB  1 
ATOM   3621 C CG  . ASP B 1 171 ? -19.378 -30.967 -20.987 1.00  38.79 ? 171  ASP B CG  1 
ATOM   3622 O OD1 . ASP B 1 171 ? -18.697 -31.318 -19.995 1.00  41.11 ? 171  ASP B OD1 1 
ATOM   3623 O OD2 . ASP B 1 171 ? -19.557 -29.751 -21.258 1.00  40.56 ? 171  ASP B OD2 1 
ATOM   3624 N N   . ALA B 1 172 ? -17.724 -33.793 -22.433 1.00  36.84 ? 172  ALA B N   1 
ATOM   3625 C CA  . ALA B 1 172 ? -16.323 -34.226 -22.501 1.00  37.20 ? 172  ALA B CA  1 
ATOM   3626 C C   . ALA B 1 172 ? -15.372 -33.252 -21.792 1.00  37.19 ? 172  ALA B C   1 
ATOM   3627 O O   . ALA B 1 172 ? -14.338 -33.649 -21.250 1.00  36.84 ? 172  ALA B O   1 
ATOM   3628 C CB  . ALA B 1 172 ? -15.902 -34.421 -23.948 1.00  37.38 ? 172  ALA B CB  1 
ATOM   3629 N N   . GLY B 1 173 ? -15.736 -31.974 -21.796 1.00  37.36 ? 173  GLY B N   1 
ATOM   3630 C CA  . GLY B 1 173 ? -14.923 -30.937 -21.160 1.00  37.62 ? 173  GLY B CA  1 
ATOM   3631 C C   . GLY B 1 173 ? -14.827 -31.058 -19.646 1.00  37.86 ? 173  GLY B C   1 
ATOM   3632 O O   . GLY B 1 173 ? -13.826 -30.631 -19.036 1.00  37.38 ? 173  GLY B O   1 
ATOM   3633 N N   . GLY B 1 174 ? -15.859 -31.654 -19.041 1.00  38.09 ? 174  GLY B N   1 
ATOM   3634 C CA  . GLY B 1 174 ? -15.979 -31.726 -17.581 1.00  38.47 ? 174  GLY B CA  1 
ATOM   3635 C C   . GLY B 1 174 ? -15.282 -32.917 -16.937 1.00  38.73 ? 174  GLY B C   1 
ATOM   3636 O O   . GLY B 1 174 ? -15.515 -33.214 -15.748 1.00  39.17 ? 174  GLY B O   1 
ATOM   3637 N N   . ALA B 1 175 ? -14.413 -33.581 -17.699 1.00  38.14 ? 175  ALA B N   1 
ATOM   3638 C CA  . ALA B 1 175 ? -13.800 -34.819 -17.246 1.00  37.98 ? 175  ALA B CA  1 
ATOM   3639 C C   . ALA B 1 175 ? -12.929 -34.658 -15.999 1.00  37.74 ? 175  ALA B C   1 
ATOM   3640 O O   . ALA B 1 175 ? -13.140 -35.364 -15.014 1.00  37.86 ? 175  ALA B O   1 
ATOM   3641 C CB  . ALA B 1 175 ? -13.030 -35.505 -18.381 1.00  38.06 ? 175  ALA B CB  1 
ATOM   3642 N N   . LYS B 1 176 ? -11.969 -33.739 -16.030 0.10  37.54 ? 176  LYS B N   1 
ATOM   3643 C CA  . LYS B 1 176 ? -11.091 -33.529 -14.877 0.10  37.35 ? 176  LYS B CA  1 
ATOM   3644 C C   . LYS B 1 176 ? -11.870 -33.223 -13.598 0.10  37.30 ? 176  LYS B C   1 
ATOM   3645 O O   . LYS B 1 176 ? -11.506 -33.677 -12.517 0.10  37.21 ? 176  LYS B O   1 
ATOM   3646 C CB  . LYS B 1 176 ? -10.071 -32.427 -15.161 0.10  37.27 ? 176  LYS B CB  1 
ATOM   3647 C CG  . LYS B 1 176 ? -8.761  -32.943 -15.725 0.10  37.11 ? 176  LYS B CG  1 
ATOM   3648 C CD  . LYS B 1 176 ? -7.784  -31.810 -15.981 0.10  36.81 ? 176  LYS B CD  1 
ATOM   3649 C CE  . LYS B 1 176 ? -6.354  -32.324 -16.085 0.10  36.60 ? 176  LYS B CE  1 
ATOM   3650 N NZ  . LYS B 1 176 ? -6.206  -33.408 -17.096 0.10  36.29 ? 176  LYS B NZ  1 
ATOM   3651 N N   . ARG B 1 177 ? -12.952 -32.467 -13.741 0.60  37.29 ? 177  ARG B N   1 
ATOM   3652 C CA  . ARG B 1 177 ? -13.780 -32.053 -12.619 0.60  37.45 ? 177  ARG B CA  1 
ATOM   3653 C C   . ARG B 1 177 ? -14.442 -33.229 -11.912 0.60  37.54 ? 177  ARG B C   1 
ATOM   3654 O O   . ARG B 1 177 ? -14.391 -33.319 -10.681 0.60  37.24 ? 177  ARG B O   1 
ATOM   3655 C CB  . ARG B 1 177 ? -14.845 -31.055 -13.085 0.60  37.64 ? 177  ARG B CB  1 
ATOM   3656 C CG  . ARG B 1 177 ? -15.645 -30.414 -11.951 0.60  37.95 ? 177  ARG B CG  1 
ATOM   3657 C CD  . ARG B 1 177 ? -16.757 -29.515 -12.468 0.60  38.56 ? 177  ARG B CD  1 
ATOM   3658 N NE  . ARG B 1 177 ? -16.230 -28.321 -13.123 0.60  40.76 ? 177  ARG B NE  1 
ATOM   3659 C CZ  . ARG B 1 177 ? -15.805 -27.224 -12.494 0.60  42.32 ? 177  ARG B CZ  1 
ATOM   3660 N NH1 . ARG B 1 177 ? -15.838 -27.132 -11.169 0.60  41.81 ? 177  ARG B NH1 1 
ATOM   3661 N NH2 . ARG B 1 177 ? -15.344 -26.198 -13.200 0.60  43.52 ? 177  ARG B NH2 1 
ATOM   3662 N N   . VAL B 1 178 ? -15.078 -34.117 -12.680 1.00  37.81 ? 178  VAL B N   1 
ATOM   3663 C CA  . VAL B 1 178 ? -15.658 -35.325 -12.087 1.00  37.97 ? 178  VAL B CA  1 
ATOM   3664 C C   . VAL B 1 178 ? -14.573 -36.210 -11.488 1.00  38.03 ? 178  VAL B C   1 
ATOM   3665 O O   . VAL B 1 178 ? -14.589 -36.459 -10.295 1.00  38.43 ? 178  VAL B O   1 
ATOM   3666 C CB  . VAL B 1 178 ? -16.595 -36.118 -13.031 1.00  37.90 ? 178  VAL B CB  1 
ATOM   3667 C CG1 . VAL B 1 178 ? -17.717 -35.218 -13.543 1.00  38.20 ? 178  VAL B CG1 1 
ATOM   3668 C CG2 . VAL B 1 178 ? -15.825 -36.775 -14.179 1.00  38.57 ? 178  VAL B CG2 1 
ATOM   3669 N N   . THR B 1 179 ? -13.603 -36.636 -12.289 1.00  38.20 ? 179  THR B N   1 
ATOM   3670 C CA  . THR B 1 179 ? -12.546 -37.519 -11.791 1.00  38.39 ? 179  THR B CA  1 
ATOM   3671 C C   . THR B 1 179 ? -12.004 -37.042 -10.455 1.00  38.45 ? 179  THR B C   1 
ATOM   3672 O O   . THR B 1 179 ? -11.763 -37.841 -9.554  1.00  38.61 ? 179  THR B O   1 
ATOM   3673 C CB  . THR B 1 179 ? -11.369 -37.594 -12.748 1.00  38.38 ? 179  THR B CB  1 
ATOM   3674 O OG1 . THR B 1 179 ? -10.850 -36.271 -12.944 1.00  38.54 ? 179  THR B OG1 1 
ATOM   3675 C CG2 . THR B 1 179 ? -11.799 -38.197 -14.067 1.00  39.08 ? 179  THR B CG2 1 
ATOM   3676 N N   . SER B 1 180 ? -11.814 -35.733 -10.337 1.00  38.56 ? 180  SER B N   1 
ATOM   3677 C CA  . SER B 1 180 ? -11.263 -35.129 -9.135  1.00  38.47 ? 180  SER B CA  1 
ATOM   3678 C C   . SER B 1 180 ? -12.135 -35.394 -7.918  1.00  38.52 ? 180  SER B C   1 
ATOM   3679 O O   . SER B 1 180 ? -11.607 -35.552 -6.813  1.00  38.64 ? 180  SER B O   1 
ATOM   3680 C CB  . SER B 1 180 ? -11.048 -33.627 -9.346  1.00  38.50 ? 180  SER B CB  1 
ATOM   3681 O OG  . SER B 1 180 ? -11.392 -32.881 -8.193  1.00  38.85 ? 180  SER B OG  1 
ATOM   3682 N N   . ILE B 1 181 ? -13.459 -35.425 -8.123  1.00  38.52 ? 181  ILE B N   1 
ATOM   3683 C CA  . ILE B 1 181 ? -14.426 -35.739 -7.055  1.00  38.42 ? 181  ILE B CA  1 
ATOM   3684 C C   . ILE B 1 181 ? -14.489 -37.244 -6.843  1.00  38.52 ? 181  ILE B C   1 
ATOM   3685 O O   . ILE B 1 181 ? -14.566 -37.717 -5.710  1.00  38.60 ? 181  ILE B O   1 
ATOM   3686 C CB  . ILE B 1 181 ? -15.854 -35.227 -7.371  1.00  38.35 ? 181  ILE B CB  1 
ATOM   3687 C CG1 . ILE B 1 181 ? -15.859 -33.700 -7.585  1.00  38.30 ? 181  ILE B CG1 1 
ATOM   3688 C CG2 . ILE B 1 181 ? -16.829 -35.620 -6.245  1.00  38.53 ? 181  ILE B CG2 1 
ATOM   3689 C CD1 . ILE B 1 181 ? -17.269 -33.095 -7.801  1.00  37.86 ? 181  ILE B CD1 1 
ATOM   3690 N N   . ALA B 1 182 ? -14.472 -37.980 -7.954  1.00  38.77 ? 182  ALA B N   1 
ATOM   3691 C CA  . ALA B 1 182 ? -14.476 -39.434 -7.951  1.00  38.76 ? 182  ALA B CA  1 
ATOM   3692 C C   . ALA B 1 182 ? -13.368 -39.951 -7.047  1.00  39.06 ? 182  ALA B C   1 
ATOM   3693 O O   . ALA B 1 182 ? -13.639 -40.660 -6.059  1.00  39.36 ? 182  ALA B O   1 
ATOM   3694 C CB  . ALA B 1 182 ? -14.303 -39.951 -9.352  1.00  38.65 ? 182  ALA B CB  1 
ATOM   3695 N N   . ASP B 1 183 ? -12.134 -39.556 -7.362  0.60  38.91 ? 183  ASP B N   1 
ATOM   3696 C CA  . ASP B 1 183 ? -10.956 -39.977 -6.616  0.60  38.81 ? 183  ASP B CA  1 
ATOM   3697 C C   . ASP B 1 183 ? -11.050 -39.634 -5.129  0.60  38.82 ? 183  ASP B C   1 
ATOM   3698 O O   . ASP B 1 183 ? -10.738 -40.470 -4.282  0.60  38.71 ? 183  ASP B O   1 
ATOM   3699 C CB  . ASP B 1 183 ? -9.683  -39.393 -7.241  0.60  38.76 ? 183  ASP B CB  1 
ATOM   3700 C CG  . ASP B 1 183 ? -9.464  -39.856 -8.679  0.60  38.84 ? 183  ASP B CG  1 
ATOM   3701 O OD1 . ASP B 1 183 ? -10.351 -40.517 -9.259  0.60  38.49 ? 183  ASP B OD1 1 
ATOM   3702 O OD2 . ASP B 1 183 ? -8.397  -39.548 -9.241  0.60  40.11 ? 183  ASP B OD2 1 
ATOM   3703 N N   . ARG B 1 184 ? -11.498 -38.424 -4.811  0.70  39.08 ? 184  ARG B N   1 
ATOM   3704 C CA  . ARG B 1 184 ? -11.601 -37.998 -3.410  0.70  39.64 ? 184  ARG B CA  1 
ATOM   3705 C C   . ARG B 1 184 ? -12.576 -38.833 -2.589  0.70  39.84 ? 184  ARG B C   1 
ATOM   3706 O O   . ARG B 1 184 ? -12.238 -39.282 -1.501  0.70  39.93 ? 184  ARG B O   1 
ATOM   3707 C CB  . ARG B 1 184 ? -11.934 -36.509 -3.300  0.70  39.66 ? 184  ARG B CB  1 
ATOM   3708 C CG  . ARG B 1 184 ? -10.709 -35.604 -3.328  0.70  40.44 ? 184  ARG B CG  1 
ATOM   3709 C CD  . ARG B 1 184 ? -11.097 -34.147 -3.074  0.70  42.74 ? 184  ARG B CD  1 
ATOM   3710 N NE  . ARG B 1 184 ? -10.033 -33.192 -3.404  0.70  44.17 ? 184  ARG B NE  1 
ATOM   3711 C CZ  . ARG B 1 184 ? -9.611  -32.912 -4.638  0.70  45.15 ? 184  ARG B CZ  1 
ATOM   3712 N NH1 . ARG B 1 184 ? -10.139 -33.524 -5.702  0.70  45.27 ? 184  ARG B NH1 1 
ATOM   3713 N NH2 . ARG B 1 184 ? -8.642  -32.019 -4.803  0.70  45.39 ? 184  ARG B NH2 1 
ATOM   3714 N N   . LEU B 1 185 ? -13.775 -39.053 -3.122  1.00  40.41 ? 185  LEU B N   1 
ATOM   3715 C CA  . LEU B 1 185 ? -14.765 -39.927 -2.483  1.00  40.67 ? 185  LEU B CA  1 
ATOM   3716 C C   . LEU B 1 185 ? -14.449 -41.414 -2.658  1.00  41.15 ? 185  LEU B C   1 
ATOM   3717 O O   . LEU B 1 185 ? -15.165 -42.256 -2.102  1.00  41.49 ? 185  LEU B O   1 
ATOM   3718 C CB  . LEU B 1 185 ? -16.171 -39.654 -3.027  1.00  40.47 ? 185  LEU B CB  1 
ATOM   3719 C CG  . LEU B 1 185 ? -16.845 -38.298 -2.832  1.00  39.90 ? 185  LEU B CG  1 
ATOM   3720 C CD1 . LEU B 1 185 ? -18.192 -38.249 -3.583  1.00  38.67 ? 185  LEU B CD1 1 
ATOM   3721 C CD2 . LEU B 1 185 ? -17.050 -37.993 -1.338  1.00  40.30 ? 185  LEU B CD2 1 
ATOM   3722 N N   . ASN B 1 186 ? -13.396 -41.713 -3.429  1.00  41.36 ? 186  ASN B N   1 
ATOM   3723 C CA  . ASN B 1 186 ? -12.970 -43.074 -3.759  1.00  41.53 ? 186  ASN B CA  1 
ATOM   3724 C C   . ASN B 1 186 ? -14.121 -43.876 -4.354  1.00  41.72 ? 186  ASN B C   1 
ATOM   3725 O O   . ASN B 1 186 ? -14.496 -44.949 -3.847  1.00  41.92 ? 186  ASN B O   1 
ATOM   3726 C CB  . ASN B 1 186 ? -12.332 -43.775 -2.551  1.00  41.42 ? 186  ASN B CB  1 
ATOM   3727 C CG  . ASN B 1 186 ? -11.625 -45.073 -2.926  1.00  42.19 ? 186  ASN B CG  1 
ATOM   3728 O OD1 . ASN B 1 186 ? -11.662 -46.050 -2.166  1.00  43.41 ? 186  ASN B OD1 1 
ATOM   3729 N ND2 . ASN B 1 186 ? -10.978 -45.093 -4.099  1.00  41.59 ? 186  ASN B ND2 1 
ATOM   3730 N N   . VAL B 1 187 ? -14.692 -43.305 -5.418  1.00  41.62 ? 187  VAL B N   1 
ATOM   3731 C CA  . VAL B 1 187 ? -15.793 -43.907 -6.183  1.00  41.37 ? 187  VAL B CA  1 
ATOM   3732 C C   . VAL B 1 187 ? -15.495 -43.840 -7.693  1.00  41.43 ? 187  VAL B C   1 
ATOM   3733 O O   . VAL B 1 187 ? -14.516 -43.215 -8.110  1.00  41.54 ? 187  VAL B O   1 
ATOM   3734 C CB  . VAL B 1 187 ? -17.166 -43.246 -5.847  1.00  41.13 ? 187  VAL B CB  1 
ATOM   3735 C CG1 . VAL B 1 187 ? -17.334 -43.093 -4.357  1.00  40.76 ? 187  VAL B CG1 1 
ATOM   3736 C CG2 . VAL B 1 187 ? -17.300 -41.884 -6.496  1.00  41.42 ? 187  VAL B CG2 1 
ATOM   3737 N N   . ASP B 1 188 ? -16.336 -44.487 -8.496  1.00  41.50 ? 188  ASP B N   1 
ATOM   3738 C CA  . ASP B 1 188 ? -16.158 -44.553 -9.952  1.00  41.37 ? 188  ASP B CA  1 
ATOM   3739 C C   . ASP B 1 188 ? -16.667 -43.279 -10.658 1.00  41.03 ? 188  ASP B C   1 
ATOM   3740 O O   . ASP B 1 188 ? -17.413 -42.493 -10.056 1.00  41.11 ? 188  ASP B O   1 
ATOM   3741 C CB  . ASP B 1 188 ? -16.852 -45.814 -10.484 1.00  41.46 ? 188  ASP B CB  1 
ATOM   3742 C CG  . ASP B 1 188 ? -16.308 -47.093 -9.839  1.00  42.62 ? 188  ASP B CG  1 
ATOM   3743 O OD1 . ASP B 1 188 ? -15.231 -47.039 -9.201  1.00  43.93 ? 188  ASP B OD1 1 
ATOM   3744 O OD2 . ASP B 1 188 ? -16.938 -48.163 -9.957  1.00  44.86 ? 188  ASP B OD2 1 
ATOM   3745 N N   . PHE B 1 189 ? -16.241 -43.072 -11.908 1.00  40.41 ? 189  PHE B N   1 
ATOM   3746 C CA  . PHE B 1 189 ? -16.688 -41.945 -12.736 1.00  40.00 ? 189  PHE B CA  1 
ATOM   3747 C C   . PHE B 1 189 ? -17.200 -42.416 -14.111 1.00  39.85 ? 189  PHE B C   1 
ATOM   3748 O O   . PHE B 1 189 ? -16.689 -43.393 -14.678 1.00  39.63 ? 189  PHE B O   1 
ATOM   3749 C CB  . PHE B 1 189 ? -15.554 -40.920 -12.924 1.00  39.91 ? 189  PHE B CB  1 
ATOM   3750 C CG  . PHE B 1 189 ? -14.567 -41.291 -14.014 1.00  40.36 ? 189  PHE B CG  1 
ATOM   3751 C CD1 . PHE B 1 189 ? -14.816 -40.967 -15.342 1.00  40.35 ? 189  PHE B CD1 1 
ATOM   3752 C CD2 . PHE B 1 189 ? -13.395 -41.985 -13.711 1.00  40.96 ? 189  PHE B CD2 1 
ATOM   3753 C CE1 . PHE B 1 189 ? -13.921 -41.332 -16.347 1.00  40.59 ? 189  PHE B CE1 1 
ATOM   3754 C CE2 . PHE B 1 189 ? -12.490 -42.349 -14.713 1.00  39.92 ? 189  PHE B CE2 1 
ATOM   3755 C CZ  . PHE B 1 189 ? -12.752 -42.020 -16.026 1.00  40.25 ? 189  PHE B CZ  1 
ATOM   3756 N N   . ALA B 1 190 ? -18.201 -41.720 -14.646 1.00  39.66 ? 190  ALA B N   1 
ATOM   3757 C CA  . ALA B 1 190 ? -18.639 -41.948 -16.032 1.00  39.43 ? 190  ALA B CA  1 
ATOM   3758 C C   . ALA B 1 190 ? -18.683 -40.639 -16.811 1.00  39.24 ? 190  ALA B C   1 
ATOM   3759 O O   . ALA B 1 190 ? -18.700 -39.559 -16.215 1.00  39.08 ? 190  ALA B O   1 
ATOM   3760 C CB  . ALA B 1 190 ? -19.989 -42.641 -16.076 1.00  39.59 ? 190  ALA B CB  1 
ATOM   3761 N N   . LEU B 1 191 ? -18.711 -40.740 -18.136 1.00  39.00 ? 191  LEU B N   1 
ATOM   3762 C CA  . LEU B 1 191 ? -18.588 -39.572 -18.989 1.00  39.15 ? 191  LEU B CA  1 
ATOM   3763 C C   . LEU B 1 191 ? -19.504 -39.621 -20.218 1.00  39.37 ? 191  LEU B C   1 
ATOM   3764 O O   . LEU B 1 191 ? -19.367 -40.488 -21.082 1.00  39.71 ? 191  LEU B O   1 
ATOM   3765 C CB  . LEU B 1 191 ? -17.112 -39.389 -19.376 1.00  39.31 ? 191  LEU B CB  1 
ATOM   3766 C CG  . LEU B 1 191 ? -16.615 -38.355 -20.404 1.00  39.02 ? 191  LEU B CG  1 
ATOM   3767 C CD1 . LEU B 1 191 ? -15.154 -38.046 -20.144 1.00  38.19 ? 191  LEU B CD1 1 
ATOM   3768 C CD2 . LEU B 1 191 ? -16.789 -38.861 -21.840 1.00  38.34 ? 191  LEU B CD2 1 
ATOM   3769 N N   . ILE B 1 192 ? -20.430 -38.671 -20.287 1.00  39.63 ? 192  ILE B N   1 
ATOM   3770 C CA  . ILE B 1 192 ? -21.376 -38.583 -21.401 1.00  40.08 ? 192  ILE B CA  1 
ATOM   3771 C C   . ILE B 1 192 ? -20.874 -37.645 -22.497 1.00  40.56 ? 192  ILE B C   1 
ATOM   3772 O O   . ILE B 1 192 ? -20.548 -36.497 -22.230 1.00  40.68 ? 192  ILE B O   1 
ATOM   3773 C CB  . ILE B 1 192 ? -22.788 -38.129 -20.929 1.00  39.95 ? 192  ILE B CB  1 
ATOM   3774 C CG1 . ILE B 1 192 ? -23.463 -39.254 -20.125 1.00  39.52 ? 192  ILE B CG1 1 
ATOM   3775 C CG2 . ILE B 1 192 ? -23.660 -37.697 -22.128 1.00  39.02 ? 192  ILE B CG2 1 
ATOM   3776 C CD1 . ILE B 1 192 ? -24.644 -38.811 -19.274 1.00  38.14 ? 192  ILE B CD1 1 
ATOM   3777 N N   . HIS B 1 193 ? -20.836 -38.144 -23.728 1.00  41.07 ? 193  HIS B N   1 
ATOM   3778 C CA  . HIS B 1 193 ? -20.455 -37.345 -24.892 1.00  41.50 ? 193  HIS B CA  1 
ATOM   3779 C C   . HIS B 1 193 ? -21.631 -37.298 -25.850 1.00  41.61 ? 193  HIS B C   1 
ATOM   3780 O O   . HIS B 1 193 ? -22.263 -38.329 -26.092 1.00  42.14 ? 193  HIS B O   1 
ATOM   3781 C CB  . HIS B 1 193 ? -19.223 -37.975 -25.560 1.00  41.61 ? 193  HIS B CB  1 
ATOM   3782 C CG  . HIS B 1 193 ? -18.837 -37.354 -26.865 1.00  41.89 ? 193  HIS B CG  1 
ATOM   3783 N ND1 . HIS B 1 193 ? -18.744 -35.991 -27.052 1.00  41.61 ? 193  HIS B ND1 1 
ATOM   3784 C CD2 . HIS B 1 193 ? -18.483 -37.920 -28.044 1.00  43.96 ? 193  HIS B CD2 1 
ATOM   3785 C CE1 . HIS B 1 193 ? -18.375 -35.742 -28.296 1.00  42.87 ? 193  HIS B CE1 1 
ATOM   3786 N NE2 . HIS B 1 193 ? -18.209 -36.896 -28.921 1.00  44.30 ? 193  HIS B NE2 1 
ATOM   3787 N N   . LYS B 1 194 ? -21.939 -36.107 -26.364 0.20  41.48 ? 194  LYS B N   1 
ATOM   3788 C CA  . LYS B 1 194 ? -23.017 -35.935 -27.336 0.20  41.34 ? 194  LYS B CA  1 
ATOM   3789 C C   . LYS B 1 194 ? -22.440 -35.723 -28.728 0.20  41.35 ? 194  LYS B C   1 
ATOM   3790 O O   . LYS B 1 194 ? -21.667 -34.792 -28.947 0.20  41.34 ? 194  LYS B O   1 
ATOM   3791 C CB  . LYS B 1 194 ? -23.912 -34.753 -26.954 0.20  41.32 ? 194  LYS B CB  1 
ATOM   3792 C CG  . LYS B 1 194 ? -25.070 -34.521 -27.918 0.20  41.11 ? 194  LYS B CG  1 
ATOM   3793 C CD  . LYS B 1 194 ? -26.152 -33.659 -27.295 0.20  40.91 ? 194  LYS B CD  1 
ATOM   3794 C CE  . LYS B 1 194 ? -27.479 -33.843 -28.014 0.20  41.22 ? 194  LYS B CE  1 
ATOM   3795 N NZ  . LYS B 1 194 ? -28.629 -33.301 -27.227 0.20  41.31 ? 194  LYS B NZ  1 
ATOM   3796 N N   . GLU B 1 195 ? -22.819 -36.594 -29.659 1.00  41.41 ? 195  GLU B N   1 
ATOM   3797 C CA  . GLU B 1 195 ? -22.355 -36.531 -31.065 1.00  41.42 ? 195  GLU B CA  1 
ATOM   3798 C C   . GLU B 1 195 ? -23.369 -35.800 -31.972 1.00  40.59 ? 195  GLU B C   1 
ATOM   3799 O O   . GLU B 1 195 ? -24.118 -36.445 -32.731 1.00  41.22 ? 195  GLU B O   1 
ATOM   3800 C CB  . GLU B 1 195 ? -22.122 -37.946 -31.638 1.00  41.70 ? 195  GLU B CB  1 
ATOM   3801 C CG  . GLU B 1 195 ? -21.468 -38.962 -30.704 1.00  43.84 ? 195  GLU B CG  1 
ATOM   3802 C CD  . GLU B 1 195 ? -21.456 -40.379 -31.291 1.00  46.51 ? 195  GLU B CD  1 
ATOM   3803 O OE1 . GLU B 1 195 ? -22.483 -40.810 -31.872 1.00  46.88 ? 195  GLU B OE1 1 
ATOM   3804 O OE2 . GLU B 1 195 ? -20.415 -41.073 -31.155 1.00  47.48 ? 195  GLU B OE2 1 
ATOM   3805 N N   . ARG B 1 196 ? -23.377 -34.467 -31.911 0.10  38.82 ? 196  ARG B N   1 
ATOM   3806 C CA  . ARG B 1 196 ? -24.425 -33.638 -32.546 0.10  37.05 ? 196  ARG B CA  1 
ATOM   3807 C C   . ARG B 1 196 ? -24.897 -33.984 -33.968 0.10  36.21 ? 196  ARG B C   1 
ATOM   3808 O O   . ARG B 1 196 ? -24.170 -34.572 -34.770 0.10  35.99 ? 196  ARG B O   1 
ATOM   3809 C CB  . ARG B 1 196 ? -24.040 -32.164 -32.543 0.10  36.89 ? 196  ARG B CB  1 
ATOM   3810 C CG  . ARG B 1 196 ? -24.590 -31.464 -33.771 0.10  35.88 ? 196  ARG B CG  1 
ATOM   3811 C CD  . ARG B 1 196 ? -23.995 -32.098 -35.018 0.10  34.03 ? 196  ARG B CD  1 
ATOM   3812 N NE  . ARG B 1 196 ? -22.615 -31.660 -35.149 0.10  32.70 ? 196  ARG B NE  1 
ATOM   3813 C CZ  . ARG B 1 196 ? -22.144 -30.588 -34.522 0.10  31.97 ? 196  ARG B CZ  1 
ATOM   3814 N NH1 . ARG B 1 196 ? -22.954 -29.868 -33.749 0.10  31.69 ? 196  ARG B NH1 1 
ATOM   3815 N NH2 . ARG B 1 196 ? -20.876 -30.228 -34.670 0.10  31.42 ? 196  ARG B NH2 1 
ATOM   3816 N N   . LYS B 1 197 ? -26.126 -33.560 -34.260 0.10  35.28 ? 197  LYS B N   1 
ATOM   3817 C CA  . LYS B 1 197 ? -26.737 -33.701 -35.578 0.10  34.56 ? 197  LYS B CA  1 
ATOM   3818 C C   . LYS B 1 197 ? -26.158 -32.678 -36.547 0.10  34.40 ? 197  LYS B C   1 
ATOM   3819 O O   . LYS B 1 197 ? -26.833 -31.719 -36.924 0.10  34.23 ? 197  LYS B O   1 
ATOM   3820 C CB  . LYS B 1 197 ? -28.252 -33.495 -35.490 0.10  34.40 ? 197  LYS B CB  1 
ATOM   3821 C CG  . LYS B 1 197 ? -28.651 -32.076 -35.065 0.10  33.88 ? 197  LYS B CG  1 
ATOM   3822 C CD  . LYS B 1 197 ? -30.135 -31.797 -35.306 0.10  32.94 ? 197  LYS B CD  1 
ATOM   3823 C CE  . LYS B 1 197 ? -30.393 -31.303 -36.726 0.10  32.28 ? 197  LYS B CE  1 
ATOM   3824 N NZ  . LYS B 1 197 ? -31.687 -30.551 -36.826 0.10  31.95 ? 197  LYS B NZ  1 
ATOM   3825 N N   . ASP B 1 203 ? -27.193 -36.679 -33.287 0.010 40.20 ? 203  ASP B N   1 
ATOM   3826 C CA  . ASP B 1 203 ? -28.018 -36.097 -32.234 0.010 40.20 ? 203  ASP B CA  1 
ATOM   3827 C C   . ASP B 1 203 ? -28.252 -37.119 -31.122 0.010 40.23 ? 203  ASP B C   1 
ATOM   3828 O O   . ASP B 1 203 ? -29.381 -37.319 -30.671 0.010 40.23 ? 203  ASP B O   1 
ATOM   3829 C CB  . ASP B 1 203 ? -29.348 -35.606 -32.808 0.010 40.19 ? 203  ASP B CB  1 
ATOM   3830 C CG  . ASP B 1 203 ? -29.886 -34.390 -32.081 0.010 40.15 ? 203  ASP B CG  1 
ATOM   3831 O OD1 . ASP B 1 203 ? -29.841 -34.373 -30.832 0.010 40.13 ? 203  ASP B OD1 1 
ATOM   3832 O OD2 . ASP B 1 203 ? -30.358 -33.452 -32.761 0.010 40.11 ? 203  ASP B OD2 1 
ATOM   3833 N N   . ARG B 1 204 ? -27.170 -37.760 -30.689 0.10  40.28 ? 204  ARG B N   1 
ATOM   3834 C CA  . ARG B 1 204 ? -27.229 -38.802 -29.672 0.10  40.34 ? 204  ARG B CA  1 
ATOM   3835 C C   . ARG B 1 204 ? -26.116 -38.606 -28.643 0.10  40.41 ? 204  ARG B C   1 
ATOM   3836 O O   . ARG B 1 204 ? -25.184 -37.836 -28.870 0.10  40.38 ? 204  ARG B O   1 
ATOM   3837 C CB  . ARG B 1 204 ? -27.105 -40.182 -30.324 0.10  40.35 ? 204  ARG B CB  1 
ATOM   3838 C CG  . ARG B 1 204 ? -28.318 -40.602 -31.137 0.10  40.38 ? 204  ARG B CG  1 
ATOM   3839 C CD  . ARG B 1 204 ? -29.505 -40.884 -30.235 0.10  40.47 ? 204  ARG B CD  1 
ATOM   3840 N NE  . ARG B 1 204 ? -29.262 -42.023 -29.355 0.10  40.51 ? 204  ARG B NE  1 
ATOM   3841 C CZ  . ARG B 1 204 ? -28.283 -42.905 -29.529 0.10  40.72 ? 204  ARG B CZ  1 
ATOM   3842 N NH1 . ARG B 1 204 ? -27.454 -42.786 -30.559 0.10  40.71 ? 204  ARG B NH1 1 
ATOM   3843 N NH2 . ARG B 1 204 ? -28.134 -43.908 -28.674 0.10  40.75 ? 204  ARG B NH2 1 
ATOM   3844 N N   . MET B 1 205 ? -26.224 -39.309 -27.519 1.00  40.52 ? 205  MET B N   1 
ATOM   3845 C CA  . MET B 1 205 ? -25.235 -39.256 -26.446 1.00  40.68 ? 205  MET B CA  1 
ATOM   3846 C C   . MET B 1 205 ? -24.625 -40.636 -26.222 1.00  40.45 ? 205  MET B C   1 
ATOM   3847 O O   . MET B 1 205 ? -25.324 -41.646 -26.305 1.00  40.86 ? 205  MET B O   1 
ATOM   3848 C CB  . MET B 1 205 ? -25.885 -38.797 -25.142 1.00  41.02 ? 205  MET B CB  1 
ATOM   3849 C CG  . MET B 1 205 ? -26.274 -37.347 -25.093 1.00  41.74 ? 205  MET B CG  1 
ATOM   3850 S SD  . MET B 1 205 ? -27.193 -36.991 -23.590 1.00  45.15 ? 205  MET B SD  1 
ATOM   3851 C CE  . MET B 1 205 ? -26.831 -35.230 -23.428 1.00  45.81 ? 205  MET B CE  1 
ATOM   3852 N N   . VAL B 1 206 ? -23.328 -40.679 -25.932 1.00  39.82 ? 206  VAL B N   1 
ATOM   3853 C CA  . VAL B 1 206 ? -22.651 -41.954 -25.669 1.00  39.55 ? 206  VAL B CA  1 
ATOM   3854 C C   . VAL B 1 206 ? -22.011 -41.991 -24.281 1.00  39.35 ? 206  VAL B C   1 
ATOM   3855 O O   . VAL B 1 206 ? -21.363 -41.026 -23.847 1.00  39.22 ? 206  VAL B O   1 
ATOM   3856 C CB  . VAL B 1 206 ? -21.621 -42.357 -26.777 1.00  39.55 ? 206  VAL B CB  1 
ATOM   3857 C CG1 . VAL B 1 206 ? -22.287 -42.413 -28.159 1.00  39.64 ? 206  VAL B CG1 1 
ATOM   3858 C CG2 . VAL B 1 206 ? -20.424 -41.434 -26.800 1.00  39.10 ? 206  VAL B CG2 1 
ATOM   3859 N N   . LEU B 1 207 ? -22.212 -43.105 -23.581 1.00  38.95 ? 207  LEU B N   1 
ATOM   3860 C CA  . LEU B 1 207 ? -21.777 -43.214 -22.198 1.00  38.65 ? 207  LEU B CA  1 
ATOM   3861 C C   . LEU B 1 207 ? -20.576 -44.136 -22.065 1.00  38.82 ? 207  LEU B C   1 
ATOM   3862 O O   . LEU B 1 207 ? -20.517 -45.206 -22.679 1.00  39.07 ? 207  LEU B O   1 
ATOM   3863 C CB  . LEU B 1 207 ? -22.924 -43.683 -21.311 1.00  38.33 ? 207  LEU B CB  1 
ATOM   3864 C CG  . LEU B 1 207 ? -22.787 -43.800 -19.785 1.00  38.14 ? 207  LEU B CG  1 
ATOM   3865 C CD1 . LEU B 1 207 ? -22.213 -42.566 -19.098 1.00  37.98 ? 207  LEU B CD1 1 
ATOM   3866 C CD2 . LEU B 1 207 ? -24.143 -44.124 -19.198 1.00  37.10 ? 207  LEU B CD2 1 
ATOM   3867 N N   . VAL B 1 208 ? -19.604 -43.697 -21.276 1.00  38.55 ? 208  VAL B N   1 
ATOM   3868 C CA  . VAL B 1 208 ? -18.441 -44.516 -20.977 1.00  38.40 ? 208  VAL B CA  1 
ATOM   3869 C C   . VAL B 1 208 ? -18.242 -44.597 -19.455 1.00  38.34 ? 208  VAL B C   1 
ATOM   3870 O O   . VAL B 1 208 ? -18.221 -43.589 -18.757 1.00  38.52 ? 208  VAL B O   1 
ATOM   3871 C CB  . VAL B 1 208 ? -17.174 -44.021 -21.732 1.00  38.53 ? 208  VAL B CB  1 
ATOM   3872 C CG1 . VAL B 1 208 ? -17.395 -44.106 -23.256 1.00  38.05 ? 208  VAL B CG1 1 
ATOM   3873 C CG2 . VAL B 1 208 ? -16.791 -42.604 -21.310 1.00  37.54 ? 208  VAL B CG2 1 
ATOM   3874 N N   . GLY B 1 209 ? -18.132 -45.803 -18.932 1.00  38.14 ? 209  GLY B N   1 
ATOM   3875 C CA  . GLY B 1 209 ? -18.051 -45.966 -17.492 1.00  38.41 ? 209  GLY B CA  1 
ATOM   3876 C C   . GLY B 1 209 ? -19.322 -46.604 -16.979 1.00  38.52 ? 209  GLY B C   1 
ATOM   3877 O O   . GLY B 1 209 ? -20.428 -46.210 -17.360 1.00  38.73 ? 209  GLY B O   1 
ATOM   3878 N N   . ASP B 1 210 ? -19.153 -47.609 -16.130 0.50  38.63 ? 210  ASP B N   1 
ATOM   3879 C CA  . ASP B 1 210 ? -20.255 -48.397 -15.605 0.50  38.86 ? 210  ASP B CA  1 
ATOM   3880 C C   . ASP B 1 210 ? -21.068 -47.571 -14.610 0.50  39.00 ? 210  ASP B C   1 
ATOM   3881 O O   . ASP B 1 210 ? -20.513 -47.008 -13.669 0.50  38.87 ? 210  ASP B O   1 
ATOM   3882 C CB  . ASP B 1 210 ? -19.683 -49.651 -14.933 0.50  38.89 ? 210  ASP B CB  1 
ATOM   3883 C CG  . ASP B 1 210 ? -20.752 -50.600 -14.435 0.50  38.90 ? 210  ASP B CG  1 
ATOM   3884 O OD1 . ASP B 1 210 ? -20.906 -50.706 -13.198 0.50  39.16 ? 210  ASP B OD1 1 
ATOM   3885 O OD2 . ASP B 1 210 ? -21.423 -51.244 -15.272 0.50  38.58 ? 210  ASP B OD2 1 
ATOM   3886 N N   . VAL B 1 211 ? -22.376 -47.477 -14.844 1.00  39.52 ? 211  VAL B N   1 
ATOM   3887 C CA  . VAL B 1 211 ? -23.309 -46.863 -13.874 1.00  39.91 ? 211  VAL B CA  1 
ATOM   3888 C C   . VAL B 1 211 ? -24.385 -47.853 -13.369 1.00  40.21 ? 211  VAL B C   1 
ATOM   3889 O O   . VAL B 1 211 ? -25.290 -47.451 -12.629 1.00  40.44 ? 211  VAL B O   1 
ATOM   3890 C CB  . VAL B 1 211 ? -23.991 -45.539 -14.418 1.00  39.80 ? 211  VAL B CB  1 
ATOM   3891 C CG1 . VAL B 1 211 ? -22.969 -44.573 -15.019 1.00  39.05 ? 211  VAL B CG1 1 
ATOM   3892 C CG2 . VAL B 1 211 ? -25.070 -45.841 -15.448 1.00  39.90 ? 211  VAL B CG2 1 
ATOM   3893 N N   . LYS B 1 212 ? -24.267 -49.129 -13.756 0.40  40.26 ? 212  LYS B N   1 
ATOM   3894 C CA  . LYS B 1 212 ? -25.274 -50.144 -13.452 0.40  40.45 ? 212  LYS B CA  1 
ATOM   3895 C C   . LYS B 1 212 ? -25.434 -50.361 -11.958 0.40  40.87 ? 212  LYS B C   1 
ATOM   3896 O O   . LYS B 1 212 ? -24.448 -50.473 -11.233 0.40  40.92 ? 212  LYS B O   1 
ATOM   3897 C CB  . LYS B 1 212 ? -24.942 -51.469 -14.137 0.40  40.43 ? 212  LYS B CB  1 
ATOM   3898 C CG  . LYS B 1 212 ? -26.088 -52.469 -14.126 0.40  40.23 ? 212  LYS B CG  1 
ATOM   3899 C CD  . LYS B 1 212 ? -25.812 -53.634 -15.048 0.40  40.39 ? 212  LYS B CD  1 
ATOM   3900 C CE  . LYS B 1 212 ? -26.967 -54.616 -15.055 0.40  40.65 ? 212  LYS B CE  1 
ATOM   3901 N NZ  . LYS B 1 212 ? -28.237 -53.958 -15.490 0.40  41.25 ? 212  LYS B NZ  1 
ATOM   3902 N N   . ASP B 1 213 ? -26.690 -50.393 -11.514 0.94  41.45 ? 213  ASP B N   1 
ATOM   3903 C CA  . ASP B 1 213 ? -27.063 -50.626 -10.116 0.94  42.12 ? 213  ASP B CA  1 
ATOM   3904 C C   . ASP B 1 213 ? -26.375 -49.667 -9.129  0.94  41.81 ? 213  ASP B C   1 
ATOM   3905 O O   . ASP B 1 213 ? -26.341 -49.923 -7.919  0.94  41.81 ? 213  ASP B O   1 
ATOM   3906 C CB  . ASP B 1 213 ? -26.839 -52.107 -9.711  0.94  42.85 ? 213  ASP B CB  1 
ATOM   3907 C CG  . ASP B 1 213 ? -27.858 -53.074 -10.353 0.94  44.71 ? 213  ASP B CG  1 
ATOM   3908 O OD1 . ASP B 1 213 ? -27.510 -53.737 -11.367 0.94  45.46 ? 213  ASP B OD1 1 
ATOM   3909 O OD2 . ASP B 1 213 ? -28.998 -53.179 -9.830  0.94  46.55 ? 213  ASP B OD2 1 
ATOM   3910 N N   . ARG B 1 214 ? -25.850 -48.555 -9.642  0.94  41.51 ? 214  ARG B N   1 
ATOM   3911 C CA  . ARG B 1 214 ? -25.277 -47.492 -8.787  0.94  41.45 ? 214  ARG B CA  1 
ATOM   3912 C C   . ARG B 1 214 ? -26.124 -46.211 -8.773  0.94  41.19 ? 214  ARG B C   1 
ATOM   3913 O O   . ARG B 1 214 ? -26.920 -45.977 -9.682  0.94  41.32 ? 214  ARG B O   1 
ATOM   3914 C CB  . ARG B 1 214 ? -23.874 -47.118 -9.259  0.94  41.42 ? 214  ARG B CB  1 
ATOM   3915 C CG  . ARG B 1 214 ? -22.820 -48.178 -9.088  0.94  41.45 ? 214  ARG B CG  1 
ATOM   3916 C CD  . ARG B 1 214 ? -21.580 -47.773 -9.837  0.94  41.57 ? 214  ARG B CD  1 
ATOM   3917 N NE  . ARG B 1 214 ? -20.443 -48.605 -9.478  0.94  44.45 ? 214  ARG B NE  1 
ATOM   3918 C CZ  . ARG B 1 214 ? -19.516 -48.287 -8.574  0.94  45.75 ? 214  ARG B CZ  1 
ATOM   3919 N NH1 . ARG B 1 214 ? -19.554 -47.129 -7.918  0.94  45.84 ? 214  ARG B NH1 1 
ATOM   3920 N NH2 . ARG B 1 214 ? -18.526 -49.136 -8.333  0.94  47.41 ? 214  ARG B NH2 1 
ATOM   3921 N N   . VAL B 1 215 ? -25.958 -45.380 -7.747  1.00  40.83 ? 215  VAL B N   1 
ATOM   3922 C CA  . VAL B 1 215 ? -26.529 -44.030 -7.785  1.00  40.42 ? 215  VAL B CA  1 
ATOM   3923 C C   . VAL B 1 215 ? -25.622 -43.167 -8.652  1.00  40.51 ? 215  VAL B C   1 
ATOM   3924 O O   . VAL B 1 215 ? -24.402 -43.226 -8.540  1.00  40.92 ? 215  VAL B O   1 
ATOM   3925 C CB  . VAL B 1 215 ? -26.651 -43.394 -6.397  1.00  40.07 ? 215  VAL B CB  1 
ATOM   3926 C CG1 . VAL B 1 215 ? -27.047 -41.930 -6.516  1.00  39.66 ? 215  VAL B CG1 1 
ATOM   3927 C CG2 . VAL B 1 215 ? -27.673 -44.127 -5.577  1.00  40.89 ? 215  VAL B CG2 1 
ATOM   3928 N N   . ALA B 1 216 ? -26.207 -42.369 -9.532  1.00  40.17 ? 216  ALA B N   1 
ATOM   3929 C CA  . ALA B 1 216 ? -25.389 -41.570 -10.426 1.00  40.06 ? 216  ALA B CA  1 
ATOM   3930 C C   . ALA B 1 216 ? -25.585 -40.089 -10.148 1.00  39.98 ? 216  ALA B C   1 
ATOM   3931 O O   . ALA B 1 216 ? -26.718 -39.600 -10.083 1.00  39.72 ? 216  ALA B O   1 
ATOM   3932 C CB  . ALA B 1 216 ? -25.681 -41.908 -11.904 1.00  39.95 ? 216  ALA B CB  1 
ATOM   3933 N N   . ILE B 1 217 ? -24.476 -39.378 -9.953  1.00  40.00 ? 217  ILE B N   1 
ATOM   3934 C CA  . ILE B 1 217 ? -24.554 -37.959 -9.670  1.00  39.85 ? 217  ILE B CA  1 
ATOM   3935 C C   . ILE B 1 217 ? -23.955 -37.178 -10.828 1.00  40.26 ? 217  ILE B C   1 
ATOM   3936 O O   . ILE B 1 217 ? -22.776 -37.308 -11.148 1.00  40.35 ? 217  ILE B O   1 
ATOM   3937 C CB  . ILE B 1 217 ? -23.895 -37.568 -8.330  1.00  39.49 ? 217  ILE B CB  1 
ATOM   3938 C CG1 . ILE B 1 217 ? -24.414 -38.452 -7.188  1.00  38.88 ? 217  ILE B CG1 1 
ATOM   3939 C CG2 . ILE B 1 217 ? -24.205 -36.122 -8.020  1.00  39.41 ? 217  ILE B CG2 1 
ATOM   3940 C CD1 . ILE B 1 217 ? -23.540 -38.466 -5.941  1.00  35.99 ? 217  ILE B CD1 1 
ATOM   3941 N N   . LEU B 1 218 ? -24.801 -36.391 -11.476 1.00  40.86 ? 218  LEU B N   1 
ATOM   3942 C CA  . LEU B 1 218 ? -24.361 -35.530 -12.546 1.00  41.65 ? 218  LEU B CA  1 
ATOM   3943 C C   . LEU B 1 218 ? -23.762 -34.312 -11.908 1.00  42.34 ? 218  LEU B C   1 
ATOM   3944 O O   . LEU B 1 218 ? -24.372 -33.662 -11.059 1.00  42.14 ? 218  LEU B O   1 
ATOM   3945 C CB  . LEU B 1 218 ? -25.516 -35.142 -13.485 1.00  41.66 ? 218  LEU B CB  1 
ATOM   3946 C CG  . LEU B 1 218 ? -25.744 -36.052 -14.706 1.00  41.34 ? 218  LEU B CG  1 
ATOM   3947 C CD1 . LEU B 1 218 ? -27.200 -36.039 -15.177 1.00  41.65 ? 218  LEU B CD1 1 
ATOM   3948 C CD2 . LEU B 1 218 ? -24.793 -35.734 -15.850 1.00  40.38 ? 218  LEU B CD2 1 
ATOM   3949 N N   . VAL B 1 219 ? -22.536 -34.028 -12.299 1.00  43.48 ? 219  VAL B N   1 
ATOM   3950 C CA  . VAL B 1 219 ? -21.847 -32.882 -11.777 1.00  44.62 ? 219  VAL B CA  1 
ATOM   3951 C C   . VAL B 1 219 ? -21.449 -32.064 -12.960 1.00  45.96 ? 219  VAL B C   1 
ATOM   3952 O O   . VAL B 1 219 ? -20.770 -32.556 -13.862 1.00  46.67 ? 219  VAL B O   1 
ATOM   3953 C CB  . VAL B 1 219 ? -20.593 -33.264 -10.999 1.00  44.23 ? 219  VAL B CB  1 
ATOM   3954 C CG1 . VAL B 1 219 ? -19.881 -32.007 -10.528 1.00  43.92 ? 219  VAL B CG1 1 
ATOM   3955 C CG2 . VAL B 1 219 ? -20.955 -34.164 -9.822  1.00  44.22 ? 219  VAL B CG2 1 
ATOM   3956 N N   . ASP B 1 220 ? -21.900 -30.821 -12.978 1.00  47.36 ? 220  ASP B N   1 
ATOM   3957 C CA  . ASP B 1 220 ? -21.408 -29.865 -13.946 1.00  48.82 ? 220  ASP B CA  1 
ATOM   3958 C C   . ASP B 1 220 ? -21.150 -28.546 -13.241 1.00  49.81 ? 220  ASP B C   1 
ATOM   3959 O O   . ASP B 1 220 ? -21.558 -28.345 -12.103 1.00  50.27 ? 220  ASP B O   1 
ATOM   3960 C CB  . ASP B 1 220 ? -22.399 -29.702 -15.091 1.00  48.95 ? 220  ASP B CB  1 
ATOM   3961 C CG  . ASP B 1 220 ? -21.780 -29.047 -16.326 1.00  50.30 ? 220  ASP B CG  1 
ATOM   3962 O OD1 . ASP B 1 220 ? -20.571 -29.237 -16.606 1.00  51.76 ? 220  ASP B OD1 1 
ATOM   3963 O OD2 . ASP B 1 220 ? -22.524 -28.343 -17.042 1.00  51.02 ? 220  ASP B OD2 1 
ATOM   3964 N N   . ASP B 1 221 ? -20.440 -27.654 -13.906 0.94  51.25 ? 221  ASP B N   1 
ATOM   3965 C CA  . ASP B 1 221 ? -20.096 -26.378 -13.308 0.94  52.82 ? 221  ASP B CA  1 
ATOM   3966 C C   . ASP B 1 221 ? -21.265 -25.401 -13.398 0.94  53.65 ? 221  ASP B C   1 
ATOM   3967 O O   . ASP B 1 221 ? -21.430 -24.534 -12.525 0.94  53.84 ? 221  ASP B O   1 
ATOM   3968 C CB  . ASP B 1 221 ? -18.882 -25.786 -14.013 0.94  53.08 ? 221  ASP B CB  1 
ATOM   3969 C CG  . ASP B 1 221 ? -19.164 -25.462 -15.453 0.94  53.88 ? 221  ASP B CG  1 
ATOM   3970 O OD1 . ASP B 1 221 ? -19.453 -26.400 -16.243 0.94  54.69 ? 221  ASP B OD1 1 
ATOM   3971 O OD2 . ASP B 1 221 ? -19.115 -24.258 -15.779 0.94  54.80 ? 221  ASP B OD2 1 
ATOM   3972 N N   . MET B 1 222 ? -22.059 -25.530 -14.468 1.00  54.50 ? 222  MET B N   1 
ATOM   3973 C CA  . MET B 1 222 ? -23.261 -24.707 -14.638 1.00  55.17 ? 222  MET B CA  1 
ATOM   3974 C C   . MET B 1 222 ? -24.350 -25.362 -15.493 1.00  55.21 ? 222  MET B C   1 
ATOM   3975 O O   . MET B 1 222 ? -24.067 -26.147 -16.396 1.00  55.25 ? 222  MET B O   1 
ATOM   3976 C CB  . MET B 1 222 ? -22.909 -23.306 -15.161 1.00  55.30 ? 222  MET B CB  1 
ATOM   3977 C CG  . MET B 1 222 ? -22.554 -23.220 -16.640 1.00  57.00 ? 222  MET B CG  1 
ATOM   3978 S SD  . MET B 1 222 ? -22.469 -21.483 -17.173 1.00  60.83 ? 222  MET B SD  1 
ATOM   3979 C CE  . MET B 1 222 ? -20.763 -21.041 -16.744 1.00  58.75 ? 222  MET B CE  1 
ATOM   3980 N N   . ALA B 1 223 ? -25.596 -25.023 -15.189 1.00  55.38 ? 223  ALA B N   1 
ATOM   3981 C CA  . ALA B 1 223 ? -26.731 -25.543 -15.922 1.00  55.87 ? 223  ALA B CA  1 
ATOM   3982 C C   . ALA B 1 223 ? -27.646 -24.410 -16.349 1.00  56.30 ? 223  ALA B C   1 
ATOM   3983 O O   . ALA B 1 223 ? -28.262 -23.736 -15.512 1.00  56.34 ? 223  ALA B O   1 
ATOM   3984 C CB  . ALA B 1 223 ? -27.492 -26.537 -15.076 1.00  55.91 ? 223  ALA B CB  1 
ATOM   3985 N N   . ASP B 1 224 ? -27.736 -24.205 -17.657 1.00  56.82 ? 224  ASP B N   1 
ATOM   3986 C CA  . ASP B 1 224 ? -28.551 -23.122 -18.182 1.00  57.36 ? 224  ASP B CA  1 
ATOM   3987 C C   . ASP B 1 224 ? -30.011 -23.353 -18.541 1.00  57.53 ? 224  ASP B C   1 
ATOM   3988 O O   . ASP B 1 224 ? -30.896 -22.815 -17.871 1.00  58.06 ? 224  ASP B O   1 
ATOM   3989 C CB  . ASP B 1 224 ? -27.952 -22.521 -19.458 1.00  57.41 ? 224  ASP B CB  1 
ATOM   3990 C CG  . ASP B 1 224 ? -28.574 -21.188 -19.807 1.00  58.09 ? 224  ASP B CG  1 
ATOM   3991 O OD1 . ASP B 1 224 ? -29.359 -20.665 -18.977 1.00  58.42 ? 224  ASP B OD1 1 
ATOM   3992 O OD2 . ASP B 1 224 ? -28.281 -20.664 -20.900 1.00  59.17 ? 224  ASP B OD2 1 
ATOM   3993 N N   . THR B 1 225 ? -30.258 -24.152 -19.582 1.00  57.33 ? 225  THR B N   1 
ATOM   3994 C CA  . THR B 1 225 ? -31.617 -24.465 -20.029 1.00  57.17 ? 225  THR B CA  1 
ATOM   3995 C C   . THR B 1 225 ? -31.899 -25.866 -19.453 1.00  57.17 ? 225  THR B C   1 
ATOM   3996 O O   . THR B 1 225 ? -33.064 -26.271 -19.318 1.00  57.56 ? 225  THR B O   1 
ATOM   3997 C CB  . THR B 1 225 ? -31.832 -24.492 -21.573 1.00  57.23 ? 225  THR B CB  1 
ATOM   3998 O OG1 . THR B 1 225 ? -31.335 -25.724 -22.120 1.00  57.03 ? 225  THR B OG1 1 
ATOM   3999 C CG2 . THR B 1 225 ? -31.148 -23.316 -22.258 1.00  57.27 ? 225  THR B CG2 1 
ATOM   4000 N N   . CYS B 1 226 ? -30.832 -26.597 -19.122 1.00  56.66 ? 226  CYS B N   1 
ATOM   4001 C CA  . CYS B 1 226 ? -30.935 -27.969 -18.597 1.00  56.42 ? 226  CYS B CA  1 
ATOM   4002 C C   . CYS B 1 226 ? -31.317 -29.032 -19.633 1.00  55.94 ? 226  CYS B C   1 
ATOM   4003 O O   . CYS B 1 226 ? -31.594 -30.182 -19.274 1.00  56.01 ? 226  CYS B O   1 
ATOM   4004 C CB  . CYS B 1 226 ? -31.867 -28.028 -17.392 1.00  56.44 ? 226  CYS B CB  1 
ATOM   4005 S SG  . CYS B 1 226 ? -31.260 -27.009 -16.073 1.00  57.54 ? 226  CYS B SG  1 
ATOM   4006 N N   . GLY B 1 227 ? -31.304 -28.644 -20.910 1.00  55.39 ? 227  GLY B N   1 
ATOM   4007 C CA  . GLY B 1 227 ? -31.531 -29.575 -22.024 1.00  54.65 ? 227  GLY B CA  1 
ATOM   4008 C C   . GLY B 1 227 ? -30.567 -30.747 -22.015 1.00  54.20 ? 227  GLY B C   1 
ATOM   4009 O O   . GLY B 1 227 ? -30.986 -31.894 -22.182 1.00  54.53 ? 227  GLY B O   1 
ATOM   4010 N N   . THR B 1 228 ? -29.283 -30.458 -21.791 1.00  53.50 ? 228  THR B N   1 
ATOM   4011 C CA  . THR B 1 228 ? -28.240 -31.489 -21.707 1.00  52.64 ? 228  THR B CA  1 
ATOM   4012 C C   . THR B 1 228 ? -28.471 -32.452 -20.535 1.00  52.00 ? 228  THR B C   1 
ATOM   4013 O O   . THR B 1 228 ? -28.651 -33.655 -20.757 1.00  51.76 ? 228  THR B O   1 
ATOM   4014 C CB  . THR B 1 228 ? -26.797 -30.866 -21.658 1.00  52.92 ? 228  THR B CB  1 
ATOM   4015 O OG1 . THR B 1 228 ? -26.644 -29.910 -22.716 1.00  52.62 ? 228  THR B OG1 1 
ATOM   4016 C CG2 . THR B 1 228 ? -25.706 -31.941 -21.818 1.00  52.76 ? 228  THR B CG2 1 
ATOM   4017 N N   . ILE B 1 229 ? -28.483 -31.916 -19.308 0.010 51.49 ? 229  ILE B N   1 
ATOM   4018 C CA  . ILE B 1 229 ? -28.582 -32.737 -18.077 0.010 50.92 ? 229  ILE B CA  1 
ATOM   4019 C C   . ILE B 1 229 ? -29.831 -33.624 -18.017 0.010 50.38 ? 229  ILE B C   1 
ATOM   4020 O O   . ILE B 1 229 ? -29.751 -34.770 -17.562 0.010 50.30 ? 229  ILE B O   1 
ATOM   4021 C CB  . ILE B 1 229 ? -28.458 -31.898 -16.765 0.010 50.86 ? 229  ILE B CB  1 
ATOM   4022 C CG1 . ILE B 1 229 ? -29.417 -30.701 -16.776 0.010 51.11 ? 229  ILE B CG1 1 
ATOM   4023 C CG2 . ILE B 1 229 ? -27.006 -31.463 -16.533 0.010 51.04 ? 229  ILE B CG2 1 
ATOM   4024 C CD1 . ILE B 1 229 ? -29.738 -30.147 -15.387 0.010 52.30 ? 229  ILE B CD1 1 
ATOM   4025 N N   . CYS B 1 230 ? -30.967 -33.102 -18.490 1.00  49.75 ? 230  CYS B N   1 
ATOM   4026 C CA  . CYS B 1 230 ? -32.205 -33.883 -18.545 1.00  49.24 ? 230  CYS B CA  1 
ATOM   4027 C C   . CYS B 1 230 ? -32.018 -35.129 -19.410 1.00  48.57 ? 230  CYS B C   1 
ATOM   4028 O O   . CYS B 1 230 ? -32.422 -36.235 -19.016 1.00  48.98 ? 230  CYS B O   1 
ATOM   4029 C CB  . CYS B 1 230 ? -33.371 -33.044 -19.068 1.00  49.25 ? 230  CYS B CB  1 
ATOM   4030 S SG  . CYS B 1 230 ? -34.020 -31.839 -17.888 1.00  50.87 ? 230  CYS B SG  1 
ATOM   4031 N N   . HIS B 1 231 ? -31.398 -34.935 -20.576 0.60  47.21 ? 231  HIS B N   1 
ATOM   4032 C CA  . HIS B 1 231 ? -31.068 -36.014 -21.503 0.60  46.01 ? 231  HIS B CA  1 
ATOM   4033 C C   . HIS B 1 231 ? -30.000 -36.961 -20.957 0.60  45.44 ? 231  HIS B C   1 
ATOM   4034 O O   . HIS B 1 231 ? -29.852 -38.086 -21.446 0.60  45.48 ? 231  HIS B O   1 
ATOM   4035 C CB  . HIS B 1 231 ? -30.585 -35.434 -22.833 0.60  45.95 ? 231  HIS B CB  1 
ATOM   4036 C CG  . HIS B 1 231 ? -31.685 -34.910 -23.700 0.60  45.36 ? 231  HIS B CG  1 
ATOM   4037 N ND1 . HIS B 1 231 ? -32.384 -33.761 -23.404 0.60  44.49 ? 231  HIS B ND1 1 
ATOM   4038 C CD2 . HIS B 1 231 ? -32.203 -35.377 -24.860 0.60  45.26 ? 231  HIS B CD2 1 
ATOM   4039 C CE1 . HIS B 1 231 ? -33.288 -33.543 -24.342 0.60  44.38 ? 231  HIS B CE1 1 
ATOM   4040 N NE2 . HIS B 1 231 ? -33.201 -34.510 -25.237 0.60  44.96 ? 231  HIS B NE2 1 
ATOM   4041 N N   . ALA B 1 232 ? -29.247 -36.496 -19.964 1.00  44.55 ? 232  ALA B N   1 
ATOM   4042 C CA  . ALA B 1 232 ? -28.207 -37.303 -19.345 1.00  43.84 ? 232  ALA B CA  1 
ATOM   4043 C C   . ALA B 1 232 ? -28.782 -38.129 -18.208 1.00  43.47 ? 232  ALA B C   1 
ATOM   4044 O O   . ALA B 1 232 ? -28.275 -39.196 -17.897 1.00  43.54 ? 232  ALA B O   1 
ATOM   4045 C CB  . ALA B 1 232 ? -27.101 -36.423 -18.847 1.00  44.19 ? 232  ALA B CB  1 
ATOM   4046 N N   . ALA B 1 233 ? -29.853 -37.623 -17.599 1.00  43.21 ? 233  ALA B N   1 
ATOM   4047 C CA  . ALA B 1 233 ? -30.603 -38.324 -16.554 1.00  42.54 ? 233  ALA B CA  1 
ATOM   4048 C C   . ALA B 1 233 ? -31.301 -39.537 -17.138 1.00  42.29 ? 233  ALA B C   1 
ATOM   4049 O O   . ALA B 1 233 ? -31.406 -40.586 -16.494 1.00  42.30 ? 233  ALA B O   1 
ATOM   4050 C CB  . ALA B 1 233 ? -31.620 -37.398 -15.980 1.00  42.51 ? 233  ALA B CB  1 
ATOM   4051 N N   . ASP B 1 234 ? -31.788 -39.363 -18.364 1.00  41.84 ? 234  ASP B N   1 
ATOM   4052 C CA  . ASP B 1 234 ? -32.453 -40.420 -19.116 1.00  41.57 ? 234  ASP B CA  1 
ATOM   4053 C C   . ASP B 1 234 ? -31.500 -41.511 -19.585 1.00  40.88 ? 234  ASP B C   1 
ATOM   4054 O O   . ASP B 1 234 ? -31.824 -42.692 -19.510 1.00  40.69 ? 234  ASP B O   1 
ATOM   4055 C CB  . ASP B 1 234 ? -33.187 -39.817 -20.315 1.00  41.75 ? 234  ASP B CB  1 
ATOM   4056 C CG  . ASP B 1 234 ? -34.404 -39.030 -19.902 1.00  42.62 ? 234  ASP B CG  1 
ATOM   4057 O OD1 . ASP B 1 234 ? -34.774 -39.111 -18.711 1.00  43.81 ? 234  ASP B OD1 1 
ATOM   4058 O OD2 . ASP B 1 234 ? -34.992 -38.332 -20.752 1.00  44.12 ? 234  ASP B OD2 1 
ATOM   4059 N N   . LYS B 1 235 ? -30.342 -41.092 -20.088 1.00  40.16 ? 235  LYS B N   1 
ATOM   4060 C CA  . LYS B 1 235 ? -29.332 -41.998 -20.611 1.00  39.56 ? 235  LYS B CA  1 
ATOM   4061 C C   . LYS B 1 235 ? -28.728 -42.765 -19.444 1.00  38.74 ? 235  LYS B C   1 
ATOM   4062 O O   . LYS B 1 235 ? -28.455 -43.969 -19.535 1.00  38.59 ? 235  LYS B O   1 
ATOM   4063 C CB  . LYS B 1 235 ? -28.253 -41.208 -21.373 1.00  39.67 ? 235  LYS B CB  1 
ATOM   4064 C CG  . LYS B 1 235 ? -27.170 -42.061 -22.026 1.00  41.41 ? 235  LYS B CG  1 
ATOM   4065 C CD  . LYS B 1 235 ? -27.402 -42.252 -23.517 1.00  44.04 ? 235  LYS B CD  1 
ATOM   4066 C CE  . LYS B 1 235 ? -26.626 -43.464 -24.019 1.00  47.70 ? 235  LYS B CE  1 
ATOM   4067 N NZ  . LYS B 1 235 ? -26.837 -43.729 -25.502 1.00  49.76 ? 235  LYS B NZ  1 
ATOM   4068 N N   . LEU B 1 236 ? -28.551 -42.068 -18.332 1.00  37.77 ? 236  LEU B N   1 
ATOM   4069 C CA  . LEU B 1 236 ? -28.012 -42.719 -17.160 1.00  37.43 ? 236  LEU B CA  1 
ATOM   4070 C C   . LEU B 1 236 ? -28.969 -43.803 -16.634 1.00  37.38 ? 236  LEU B C   1 
ATOM   4071 O O   . LEU B 1 236 ? -28.531 -44.939 -16.404 1.00  37.28 ? 236  LEU B O   1 
ATOM   4072 C CB  . LEU B 1 236 ? -27.628 -41.690 -16.093 1.00  37.30 ? 236  LEU B CB  1 
ATOM   4073 C CG  . LEU B 1 236 ? -26.371 -40.862 -16.400 1.00  35.81 ? 236  LEU B CG  1 
ATOM   4074 C CD1 . LEU B 1 236 ? -26.158 -39.808 -15.340 1.00  35.76 ? 236  LEU B CD1 1 
ATOM   4075 C CD2 . LEU B 1 236 ? -25.137 -41.733 -16.529 1.00  35.14 ? 236  LEU B CD2 1 
ATOM   4076 N N   . LEU B 1 237 ? -30.259 -43.463 -16.488 1.00  37.02 ? 237  LEU B N   1 
ATOM   4077 C CA  . LEU B 1 237 ? -31.291 -44.445 -16.109 1.00  36.54 ? 237  LEU B CA  1 
ATOM   4078 C C   . LEU B 1 237 ? -31.375 -45.629 -17.087 1.00  36.35 ? 237  LEU B C   1 
ATOM   4079 O O   . LEU B 1 237 ? -31.256 -46.778 -16.663 1.00  36.60 ? 237  LEU B O   1 
ATOM   4080 C CB  . LEU B 1 237 ? -32.656 -43.781 -15.847 1.00  36.48 ? 237  LEU B CB  1 
ATOM   4081 C CG  . LEU B 1 237 ? -32.807 -42.909 -14.575 1.00  36.49 ? 237  LEU B CG  1 
ATOM   4082 C CD1 . LEU B 1 237 ? -34.243 -42.612 -14.231 1.00  36.17 ? 237  LEU B CD1 1 
ATOM   4083 C CD2 . LEU B 1 237 ? -32.129 -43.484 -13.339 1.00  35.45 ? 237  LEU B CD2 1 
ATOM   4084 N N   . SER B 1 238 ? -31.525 -45.350 -18.381 1.00  36.16 ? 238  SER B N   1 
ATOM   4085 C CA  . SER B 1 238 ? -31.317 -46.350 -19.453 1.00  36.21 ? 238  SER B CA  1 
ATOM   4086 C C   . SER B 1 238 ? -30.130 -47.307 -19.248 1.00  36.23 ? 238  SER B C   1 
ATOM   4087 O O   . SER B 1 238 ? -30.243 -48.500 -19.537 1.00  36.33 ? 238  SER B O   1 
ATOM   4088 C CB  . SER B 1 238 ? -31.131 -45.661 -20.807 1.00  36.18 ? 238  SER B CB  1 
ATOM   4089 O OG  . SER B 1 238 ? -32.366 -45.325 -21.407 1.00  36.87 ? 238  SER B OG  1 
ATOM   4090 N N   . ALA B 1 239 ? -28.994 -46.789 -18.777 1.00  36.23 ? 239  ALA B N   1 
ATOM   4091 C CA  . ALA B 1 239 ? -27.811 -47.635 -18.549 1.00  36.23 ? 239  ALA B CA  1 
ATOM   4092 C C   . ALA B 1 239 ? -27.721 -48.224 -17.139 1.00  36.22 ? 239  ALA B C   1 
ATOM   4093 O O   . ALA B 1 239 ? -26.632 -48.570 -16.683 1.00  36.35 ? 239  ALA B O   1 
ATOM   4094 C CB  . ALA B 1 239 ? -26.521 -46.888 -18.905 1.00  36.03 ? 239  ALA B CB  1 
ATOM   4095 N N   . GLY B 1 240 ? -28.856 -48.329 -16.451 1.00  36.31 ? 240  GLY B N   1 
ATOM   4096 C CA  . GLY B 1 240 ? -28.921 -49.079 -15.189 1.00  36.57 ? 240  GLY B CA  1 
ATOM   4097 C C   . GLY B 1 240 ? -28.673 -48.292 -13.915 1.00  36.78 ? 240  GLY B C   1 
ATOM   4098 O O   . GLY B 1 240 ? -28.355 -48.867 -12.873 1.00  36.86 ? 240  GLY B O   1 
ATOM   4099 N N   . ALA B 1 241 ? -28.828 -46.975 -13.981 1.00  36.93 ? 241  ALA B N   1 
ATOM   4100 C CA  . ALA B 1 241 ? -28.626 -46.161 -12.798 1.00  37.12 ? 241  ALA B CA  1 
ATOM   4101 C C   . ALA B 1 241 ? -29.859 -46.242 -11.907 1.00  37.43 ? 241  ALA B C   1 
ATOM   4102 O O   . ALA B 1 241 ? -30.994 -46.062 -12.366 1.00  37.50 ? 241  ALA B O   1 
ATOM   4103 C CB  . ALA B 1 241 ? -28.284 -44.725 -13.159 1.00  37.04 ? 241  ALA B CB  1 
ATOM   4104 N N   . THR B 1 242 ? -29.605 -46.559 -10.639 1.00  37.44 ? 242  THR B N   1 
ATOM   4105 C CA  . THR B 1 242 ? -30.618 -46.675 -9.609  1.00  37.19 ? 242  THR B CA  1 
ATOM   4106 C C   . THR B 1 242 ? -31.414 -45.381 -9.580  1.00  36.98 ? 242  THR B C   1 
ATOM   4107 O O   . THR B 1 242 ? -32.649 -45.381 -9.646  1.00  36.89 ? 242  THR B O   1 
ATOM   4108 C CB  . THR B 1 242 ? -29.930 -46.948 -8.276  1.00  37.20 ? 242  THR B CB  1 
ATOM   4109 O OG1 . THR B 1 242 ? -29.170 -48.157 -8.391  1.00  37.82 ? 242  THR B OG1 1 
ATOM   4110 C CG2 . THR B 1 242 ? -30.924 -47.057 -7.130  1.00  38.07 ? 242  THR B CG2 1 
ATOM   4111 N N   . ARG B 1 243 ? -30.690 -44.271 -9.518  1.00  37.21 ? 243  ARG B N   1 
ATOM   4112 C CA  . ARG B 1 243 ? -31.301 -42.947 -9.584  1.00  37.63 ? 243  ARG B CA  1 
ATOM   4113 C C   . ARG B 1 243 ? -30.276 -41.862 -9.896  1.00  37.21 ? 243  ARG B C   1 
ATOM   4114 O O   . ARG B 1 243 ? -29.058 -42.088 -9.862  1.00  37.09 ? 243  ARG B O   1 
ATOM   4115 C CB  . ARG B 1 243 ? -32.091 -42.614 -8.321  1.00  37.66 ? 243  ARG B CB  1 
ATOM   4116 C CG  . ARG B 1 243 ? -31.286 -42.699 -7.055  1.00  40.57 ? 243  ARG B CG  1 
ATOM   4117 C CD  . ARG B 1 243 ? -32.072 -43.369 -5.919  1.00  46.08 ? 243  ARG B CD  1 
ATOM   4118 N NE  . ARG B 1 243 ? -31.235 -43.463 -4.723  1.00  50.40 ? 243  ARG B NE  1 
ATOM   4119 C CZ  . ARG B 1 243 ? -31.095 -42.470 -3.844  1.00  53.63 ? 243  ARG B CZ  1 
ATOM   4120 N NH1 . ARG B 1 243 ? -31.763 -41.328 -4.025  1.00  55.32 ? 243  ARG B NH1 1 
ATOM   4121 N NH2 . ARG B 1 243 ? -30.299 -42.606 -2.784  1.00  53.45 ? 243  ARG B NH2 1 
ATOM   4122 N N   . VAL B 1 244 ? -30.785 -40.684 -10.217 1.00  36.81 ? 244  VAL B N   1 
ATOM   4123 C CA  . VAL B 1 244 ? -29.936 -39.643 -10.745 1.00  36.77 ? 244  VAL B CA  1 
ATOM   4124 C C   . VAL B 1 244 ? -29.999 -38.352 -9.922  1.00  36.87 ? 244  VAL B C   1 
ATOM   4125 O O   . VAL B 1 244 ? -31.076 -37.832 -9.608  1.00  36.87 ? 244  VAL B O   1 
ATOM   4126 C CB  . VAL B 1 244 ? -30.250 -39.395 -12.226 1.00  36.66 ? 244  VAL B CB  1 
ATOM   4127 C CG1 . VAL B 1 244 ? -29.671 -38.071 -12.684 1.00  36.31 ? 244  VAL B CG1 1 
ATOM   4128 C CG2 . VAL B 1 244 ? -29.699 -40.549 -13.062 1.00  36.53 ? 244  VAL B CG2 1 
ATOM   4129 N N   . TYR B 1 245 ? -28.821 -37.868 -9.549  1.00  36.88 ? 245  TYR B N   1 
ATOM   4130 C CA  . TYR B 1 245 ? -28.693 -36.552 -8.952  1.00  36.79 ? 245  TYR B CA  1 
ATOM   4131 C C   . TYR B 1 245 ? -27.970 -35.627 -9.924  1.00  36.95 ? 245  TYR B C   1 
ATOM   4132 O O   . TYR B 1 245 ? -27.135 -36.067 -10.720 1.00  36.97 ? 245  TYR B O   1 
ATOM   4133 C CB  . TYR B 1 245 ? -27.925 -36.637 -7.634  1.00  36.72 ? 245  TYR B CB  1 
ATOM   4134 C CG  . TYR B 1 245 ? -28.694 -37.291 -6.519  1.00  34.88 ? 245  TYR B CG  1 
ATOM   4135 C CD1 . TYR B 1 245 ? -28.533 -38.640 -6.232  1.00  33.95 ? 245  TYR B CD1 1 
ATOM   4136 C CD2 . TYR B 1 245 ? -29.580 -36.557 -5.752  1.00  33.04 ? 245  TYR B CD2 1 
ATOM   4137 C CE1 . TYR B 1 245 ? -29.240 -39.231 -5.200  1.00  34.04 ? 245  TYR B CE1 1 
ATOM   4138 C CE2 . TYR B 1 245 ? -30.284 -37.137 -4.733  1.00  32.67 ? 245  TYR B CE2 1 
ATOM   4139 C CZ  . TYR B 1 245 ? -30.113 -38.460 -4.457  1.00  33.18 ? 245  TYR B CZ  1 
ATOM   4140 O OH  . TYR B 1 245 ? -30.844 -38.996 -3.434  1.00  35.91 ? 245  TYR B OH  1 
ATOM   4141 N N   . ALA B 1 246 ? -28.310 -34.347 -9.869  1.00  37.01 ? 246  ALA B N   1 
ATOM   4142 C CA  . ALA B 1 246 ? -27.631 -33.355 -10.675 1.00  37.37 ? 246  ALA B CA  1 
ATOM   4143 C C   . ALA B 1 246 ? -27.124 -32.270 -9.747  1.00  38.00 ? 246  ALA B C   1 
ATOM   4144 O O   . ALA B 1 246 ? -27.914 -31.639 -9.038  1.00  38.35 ? 246  ALA B O   1 
ATOM   4145 C CB  . ALA B 1 246 ? -28.570 -32.782 -11.690 1.00  37.08 ? 246  ALA B CB  1 
ATOM   4146 N N   . ILE B 1 247 ? -25.811 -32.071 -9.717  1.00  38.57 ? 247  ILE B N   1 
ATOM   4147 C CA  . ILE B 1 247 ? -25.247 -30.988 -8.930  1.00  39.36 ? 247  ILE B CA  1 
ATOM   4148 C C   . ILE B 1 247 ? -24.578 -29.955 -9.844  1.00  40.30 ? 247  ILE B C   1 
ATOM   4149 O O   . ILE B 1 247 ? -23.749 -30.292 -10.679 1.00  40.51 ? 247  ILE B O   1 
ATOM   4150 C CB  . ILE B 1 247 ? -24.284 -31.501 -7.849  1.00  39.16 ? 247  ILE B CB  1 
ATOM   4151 C CG1 . ILE B 1 247 ? -24.994 -32.522 -6.944  1.00  38.31 ? 247  ILE B CG1 1 
ATOM   4152 C CG2 . ILE B 1 247 ? -23.745 -30.323 -7.031  1.00  39.59 ? 247  ILE B CG2 1 
ATOM   4153 C CD1 . ILE B 1 247 ? -24.095 -33.199 -5.899  1.00  36.22 ? 247  ILE B CD1 1 
ATOM   4154 N N   . LEU B 1 248 ? -24.982 -28.698 -9.719  1.00  41.47 ? 248  LEU B N   1 
ATOM   4155 C CA  . LEU B 1 248 ? -24.366 -27.617 -10.490 1.00  43.08 ? 248  LEU B CA  1 
ATOM   4156 C C   . LEU B 1 248 ? -23.875 -26.525 -9.556  1.00  44.08 ? 248  LEU B C   1 
ATOM   4157 O O   . LEU B 1 248 ? -24.579 -26.160 -8.613  1.00  44.63 ? 248  LEU B O   1 
ATOM   4158 C CB  . LEU B 1 248 ? -25.357 -26.988 -11.466 1.00  42.94 ? 248  LEU B CB  1 
ATOM   4159 C CG  . LEU B 1 248 ? -26.212 -27.812 -12.444 1.00  44.47 ? 248  LEU B CG  1 
ATOM   4160 C CD1 . LEU B 1 248 ? -25.520 -29.060 -13.039 1.00  44.45 ? 248  LEU B CD1 1 
ATOM   4161 C CD2 . LEU B 1 248 ? -27.569 -28.165 -11.832 1.00  44.80 ? 248  LEU B CD2 1 
ATOM   4162 N N   . THR B 1 249 ? -22.690 -25.981 -9.807  1.00  45.05 ? 249  THR B N   1 
ATOM   4163 C CA  . THR B 1 249 ? -22.252 -24.873 -8.975  1.00  46.45 ? 249  THR B CA  1 
ATOM   4164 C C   . THR B 1 249 ? -22.999 -23.583 -9.311  1.00  47.11 ? 249  THR B C   1 
ATOM   4165 O O   . THR B 1 249 ? -23.364 -22.844 -8.399  1.00  47.53 ? 249  THR B O   1 
ATOM   4166 C CB  . THR B 1 249 ? -20.693 -24.694 -8.881  1.00  46.74 ? 249  THR B CB  1 
ATOM   4167 O OG1 . THR B 1 249 ? -20.369 -23.328 -8.576  1.00  47.76 ? 249  THR B OG1 1 
ATOM   4168 C CG2 . THR B 1 249 ? -19.982 -25.113 -10.163 1.00  47.46 ? 249  THR B CG2 1 
ATOM   4169 N N   . HIS B 1 250 ? -23.260 -23.327 -10.596 1.00  47.68 ? 250  HIS B N   1 
ATOM   4170 C CA  . HIS B 1 250 ? -23.995 -22.119 -10.995 1.00  48.19 ? 250  HIS B CA  1 
ATOM   4171 C C   . HIS B 1 250 ? -25.394 -22.407 -11.562 1.00  48.46 ? 250  HIS B C   1 
ATOM   4172 O O   . HIS B 1 250 ? -25.534 -22.825 -12.726 1.00  48.28 ? 250  HIS B O   1 
ATOM   4173 C CB  . HIS B 1 250 ? -23.172 -21.279 -11.981 1.00  48.41 ? 250  HIS B CB  1 
ATOM   4174 C CG  . HIS B 1 250 ? -21.781 -20.971 -11.509 1.00  50.04 ? 250  HIS B CG  1 
ATOM   4175 N ND1 . HIS B 1 250 ? -21.517 -20.075 -10.490 1.00  51.53 ? 250  HIS B ND1 1 
ATOM   4176 C CD2 . HIS B 1 250 ? -20.574 -21.433 -11.924 1.00  50.27 ? 250  HIS B CD2 1 
ATOM   4177 C CE1 . HIS B 1 250 ? -20.211 -20.005 -10.295 1.00  50.77 ? 250  HIS B CE1 1 
ATOM   4178 N NE2 . HIS B 1 250 ? -19.616 -20.821 -11.149 1.00  50.33 ? 250  HIS B NE2 1 
ATOM   4179 N N   . GLY B 1 251 ? -26.424 -22.163 -10.746 1.00  48.87 ? 251  GLY B N   1 
ATOM   4180 C CA  . GLY B 1 251 ? -27.823 -22.402 -11.160 1.00  49.63 ? 251  GLY B CA  1 
ATOM   4181 C C   . GLY B 1 251 ? -28.453 -21.316 -12.032 1.00  50.19 ? 251  GLY B C   1 
ATOM   4182 O O   . GLY B 1 251 ? -29.124 -20.402 -11.520 1.00  50.00 ? 251  GLY B O   1 
ATOM   4183 N N   . ILE B 1 252 ? -28.254 -21.408 -13.348 1.00  50.62 ? 252  ILE B N   1 
ATOM   4184 C CA  . ILE B 1 252 ? -28.758 -20.355 -14.246 1.00  51.30 ? 252  ILE B CA  1 
ATOM   4185 C C   . ILE B 1 252 ? -30.259 -20.521 -14.529 1.00  51.52 ? 252  ILE B C   1 
ATOM   4186 O O   . ILE B 1 252 ? -31.040 -19.586 -14.323 1.00  51.64 ? 252  ILE B O   1 
ATOM   4187 C CB  . ILE B 1 252 ? -27.910 -20.187 -15.553 1.00  51.40 ? 252  ILE B CB  1 
ATOM   4188 C CG1 . ILE B 1 252 ? -26.411 -20.089 -15.211 1.00  52.39 ? 252  ILE B CG1 1 
ATOM   4189 C CG2 . ILE B 1 252 ? -28.347 -18.931 -16.291 1.00  51.09 ? 252  ILE B CG2 1 
ATOM   4190 C CD1 . ILE B 1 252 ? -25.496 -19.580 -16.357 1.00  53.29 ? 252  ILE B CD1 1 
ATOM   4191 N N   . PHE B 1 253 ? -30.650 -21.709 -14.987 1.00  51.97 ? 253  PHE B N   1 
ATOM   4192 C CA  . PHE B 1 253 ? -32.064 -22.077 -15.149 1.00  52.32 ? 253  PHE B CA  1 
ATOM   4193 C C   . PHE B 1 253 ? -32.895 -21.014 -15.866 1.00  52.87 ? 253  PHE B C   1 
ATOM   4194 O O   . PHE B 1 253 ? -33.861 -20.475 -15.317 1.00  52.99 ? 253  PHE B O   1 
ATOM   4195 C CB  . PHE B 1 253 ? -32.696 -22.457 -13.799 1.00  52.38 ? 253  PHE B CB  1 
ATOM   4196 C CG  . PHE B 1 253 ? -31.916 -23.494 -13.035 1.00  52.40 ? 253  PHE B CG  1 
ATOM   4197 C CD1 . PHE B 1 253 ? -31.605 -23.295 -11.701 1.00  52.42 ? 253  PHE B CD1 1 
ATOM   4198 C CD2 . PHE B 1 253 ? -31.467 -24.652 -13.664 1.00  51.81 ? 253  PHE B CD2 1 
ATOM   4199 C CE1 . PHE B 1 253 ? -30.875 -24.237 -11.005 1.00  52.80 ? 253  PHE B CE1 1 
ATOM   4200 C CE2 . PHE B 1 253 ? -30.735 -25.592 -12.977 1.00  51.82 ? 253  PHE B CE2 1 
ATOM   4201 C CZ  . PHE B 1 253 ? -30.442 -25.391 -11.647 1.00  52.38 ? 253  PHE B CZ  1 
ATOM   4202 N N   . SER B 1 254 ? -32.497 -20.705 -17.096 1.00  53.45 ? 254  SER B N   1 
ATOM   4203 C CA  . SER B 1 254 ? -33.267 -19.802 -17.944 1.00  53.81 ? 254  SER B CA  1 
ATOM   4204 C C   . SER B 1 254 ? -34.164 -20.578 -18.907 1.00  54.00 ? 254  SER B C   1 
ATOM   4205 O O   . SER B 1 254 ? -34.049 -21.804 -19.034 1.00  54.19 ? 254  SER B O   1 
ATOM   4206 C CB  . SER B 1 254 ? -32.333 -18.886 -18.727 1.00  53.95 ? 254  SER B CB  1 
ATOM   4207 O OG  . SER B 1 254 ? -31.393 -19.647 -19.460 1.00  54.63 ? 254  SER B OG  1 
ATOM   4208 N N   . GLY B 1 255 ? -35.051 -19.850 -19.586 1.00  54.34 ? 255  GLY B N   1 
ATOM   4209 C CA  . GLY B 1 255 ? -35.990 -20.440 -20.536 1.00  54.66 ? 255  GLY B CA  1 
ATOM   4210 C C   . GLY B 1 255 ? -36.793 -21.569 -19.916 1.00  55.17 ? 255  GLY B C   1 
ATOM   4211 O O   . GLY B 1 255 ? -37.358 -21.400 -18.830 1.00  55.40 ? 255  GLY B O   1 
ATOM   4212 N N   . PRO B 1 256 ? -36.816 -22.748 -20.575 1.00  55.50 ? 256  PRO B N   1 
ATOM   4213 C CA  . PRO B 1 256 ? -37.675 -23.838 -20.108 1.00  55.60 ? 256  PRO B CA  1 
ATOM   4214 C C   . PRO B 1 256 ? -37.037 -24.690 -19.016 1.00  56.06 ? 256  PRO B C   1 
ATOM   4215 O O   . PRO B 1 256 ? -37.549 -25.785 -18.722 1.00  56.61 ? 256  PRO B O   1 
ATOM   4216 C CB  . PRO B 1 256 ? -37.877 -24.686 -21.372 1.00  55.56 ? 256  PRO B CB  1 
ATOM   4217 C CG  . PRO B 1 256 ? -36.624 -24.487 -22.177 1.00  55.53 ? 256  PRO B CG  1 
ATOM   4218 C CD  . PRO B 1 256 ? -36.019 -23.144 -21.758 1.00  55.60 ? 256  PRO B CD  1 
ATOM   4219 N N   . ALA B 1 257 ? -35.943 -24.211 -18.422 1.00  56.15 ? 257  ALA B N   1 
ATOM   4220 C CA  . ALA B 1 257 ? -35.164 -25.036 -17.493 1.00  56.29 ? 257  ALA B CA  1 
ATOM   4221 C C   . ALA B 1 257 ? -36.028 -25.633 -16.375 1.00  56.30 ? 257  ALA B C   1 
ATOM   4222 O O   . ALA B 1 257 ? -36.012 -26.855 -16.154 1.00  56.14 ? 257  ALA B O   1 
ATOM   4223 C CB  . ALA B 1 257 ? -33.998 -24.245 -16.919 1.00  56.44 ? 257  ALA B CB  1 
ATOM   4224 N N   . ILE B 1 258 ? -36.793 -24.761 -15.710 1.00  56.30 ? 258  ILE B N   1 
ATOM   4225 C CA  . ILE B 1 258 ? -37.654 -25.133 -14.583 1.00  56.35 ? 258  ILE B CA  1 
ATOM   4226 C C   . ILE B 1 258 ? -38.666 -26.192 -14.989 1.00  56.56 ? 258  ILE B C   1 
ATOM   4227 O O   . ILE B 1 258 ? -38.926 -27.128 -14.220 1.00  56.68 ? 258  ILE B O   1 
ATOM   4228 C CB  . ILE B 1 258 ? -38.394 -23.900 -13.991 1.00  56.42 ? 258  ILE B CB  1 
ATOM   4229 C CG1 . ILE B 1 258 ? -37.408 -22.935 -13.299 1.00  56.19 ? 258  ILE B CG1 1 
ATOM   4230 C CG2 . ILE B 1 258 ? -39.531 -24.338 -13.045 1.00  56.79 ? 258  ILE B CG2 1 
ATOM   4231 C CD1 . ILE B 1 258 ? -36.689 -23.518 -12.060 1.00  56.46 ? 258  ILE B CD1 1 
ATOM   4232 N N   . SER B 1 259 ? -39.228 -26.035 -16.192 1.00  56.57 ? 259  SER B N   1 
ATOM   4233 C CA  . SER B 1 259 ? -40.121 -27.034 -16.779 1.00  56.61 ? 259  SER B CA  1 
ATOM   4234 C C   . SER B 1 259 ? -39.380 -28.344 -17.019 1.00  56.36 ? 259  SER B C   1 
ATOM   4235 O O   . SER B 1 259 ? -39.765 -29.372 -16.454 1.00  56.64 ? 259  SER B O   1 
ATOM   4236 C CB  . SER B 1 259 ? -40.758 -26.525 -18.081 1.00  56.97 ? 259  SER B CB  1 
ATOM   4237 O OG  . SER B 1 259 ? -42.012 -25.901 -17.833 1.00  57.94 ? 259  SER B OG  1 
ATOM   4238 N N   . ARG B 1 260 ? -38.316 -28.298 -17.828 1.00  55.99 ? 260  ARG B N   1 
ATOM   4239 C CA  . ARG B 1 260 ? -37.455 -29.469 -18.071 1.00  55.97 ? 260  ARG B CA  1 
ATOM   4240 C C   . ARG B 1 260 ? -37.058 -30.229 -16.794 1.00  55.77 ? 260  ARG B C   1 
ATOM   4241 O O   . ARG B 1 260 ? -36.897 -31.447 -16.829 1.00  55.67 ? 260  ARG B O   1 
ATOM   4242 C CB  . ARG B 1 260 ? -36.184 -29.079 -18.840 1.00  56.22 ? 260  ARG B CB  1 
ATOM   4243 C CG  . ARG B 1 260 ? -36.090 -29.636 -20.262 1.00  56.92 ? 260  ARG B CG  1 
ATOM   4244 C CD  . ARG B 1 260 ? -36.467 -28.588 -21.299 1.00  58.25 ? 260  ARG B CD  1 
ATOM   4245 N NE  . ARG B 1 260 ? -35.376 -27.638 -21.522 1.00  58.32 ? 260  ARG B NE  1 
ATOM   4246 C CZ  . ARG B 1 260 ? -34.805 -27.403 -22.698 1.00  57.93 ? 260  ARG B CZ  1 
ATOM   4247 N NH1 . ARG B 1 260 ? -35.227 -28.020 -23.800 1.00  57.48 ? 260  ARG B NH1 1 
ATOM   4248 N NH2 . ARG B 1 260 ? -33.816 -26.529 -22.770 1.00  57.84 ? 260  ARG B NH2 1 
ATOM   4249 N N   . ILE B 1 261 ? -36.904 -29.506 -15.681 1.00  55.54 ? 261  ILE B N   1 
ATOM   4250 C CA  . ILE B 1 261 ? -36.485 -30.107 -14.407 1.00  55.52 ? 261  ILE B CA  1 
ATOM   4251 C C   . ILE B 1 261 ? -37.617 -30.841 -13.658 1.00  55.56 ? 261  ILE B C   1 
ATOM   4252 O O   . ILE B 1 261 ? -37.437 -31.994 -13.248 1.00  55.77 ? 261  ILE B O   1 
ATOM   4253 C CB  . ILE B 1 261 ? -35.768 -29.075 -13.494 1.00  55.43 ? 261  ILE B CB  1 
ATOM   4254 C CG1 . ILE B 1 261 ? -34.359 -28.796 -14.030 1.00  55.30 ? 261  ILE B CG1 1 
ATOM   4255 C CG2 . ILE B 1 261 ? -35.704 -29.572 -12.053 1.00  55.47 ? 261  ILE B CG2 1 
ATOM   4256 C CD1 . ILE B 1 261 ? -33.540 -27.840 -13.172 1.00  55.04 ? 261  ILE B CD1 1 
ATOM   4257 N N   . ASN B 1 262 ? -38.766 -30.179 -13.486 1.00  55.45 ? 262  ASN B N   1 
ATOM   4258 C CA  . ASN B 1 262 ? -39.954 -30.808 -12.889 1.00  55.29 ? 262  ASN B CA  1 
ATOM   4259 C C   . ASN B 1 262 ? -40.355 -32.079 -13.636 1.00  54.93 ? 262  ASN B C   1 
ATOM   4260 O O   . ASN B 1 262 ? -40.931 -32.999 -13.046 1.00  54.70 ? 262  ASN B O   1 
ATOM   4261 C CB  . ASN B 1 262 ? -41.152 -29.844 -12.857 1.00  55.74 ? 262  ASN B CB  1 
ATOM   4262 C CG  . ASN B 1 262 ? -40.913 -28.619 -11.971 1.00  56.92 ? 262  ASN B CG  1 
ATOM   4263 O OD1 . ASN B 1 262 ? -40.554 -28.734 -10.791 1.00  57.50 ? 262  ASN B OD1 1 
ATOM   4264 N ND2 . ASN B 1 262 ? -41.122 -27.433 -12.543 1.00  58.99 ? 262  ASN B ND2 1 
ATOM   4265 N N   . ASN B 1 263 ? -40.051 -32.123 -14.933 1.00  54.42 ? 263  ASN B N   1 
ATOM   4266 C CA  . ASN B 1 263 ? -40.369 -33.297 -15.737 1.00  54.17 ? 263  ASN B CA  1 
ATOM   4267 C C   . ASN B 1 263 ? -39.316 -34.395 -15.643 1.00  53.62 ? 263  ASN B C   1 
ATOM   4268 O O   . ASN B 1 263 ? -39.641 -35.585 -15.703 1.00  53.68 ? 263  ASN B O   1 
ATOM   4269 C CB  . ASN B 1 263 ? -40.666 -32.908 -17.192 1.00  54.13 ? 263  ASN B CB  1 
ATOM   4270 C CG  . ASN B 1 263 ? -42.067 -32.311 -17.362 1.00  55.44 ? 263  ASN B CG  1 
ATOM   4271 O OD1 . ASN B 1 263 ? -42.291 -31.460 -18.223 1.00  57.48 ? 263  ASN B OD1 1 
ATOM   4272 N ND2 . ASN B 1 263 ? -43.012 -32.755 -16.533 1.00  56.41 ? 263  ASN B ND2 1 
ATOM   4273 N N   . ALA B 1 264 ? -38.063 -33.984 -15.463 1.00  53.12 ? 264  ALA B N   1 
ATOM   4274 C CA  . ALA B 1 264 ? -36.916 -34.893 -15.549 1.00  52.36 ? 264  ALA B CA  1 
ATOM   4275 C C   . ALA B 1 264 ? -36.835 -35.857 -14.357 1.00  51.79 ? 264  ALA B C   1 
ATOM   4276 O O   . ALA B 1 264 ? -37.351 -35.569 -13.266 1.00  51.45 ? 264  ALA B O   1 
ATOM   4277 C CB  . ALA B 1 264 ? -35.637 -34.103 -15.707 1.00  52.26 ? 264  ALA B CB  1 
ATOM   4278 N N   . CYS B 1 265 ? -36.189 -36.998 -14.580 1.00  50.88 ? 265  CYS B N   1 
ATOM   4279 C CA  . CYS B 1 265 ? -36.229 -38.090 -13.621 1.00  50.54 ? 265  CYS B CA  1 
ATOM   4280 C C   . CYS B 1 265 ? -35.201 -37.934 -12.499 1.00  49.64 ? 265  CYS B C   1 
ATOM   4281 O O   . CYS B 1 265 ? -34.838 -38.910 -11.825 1.00  49.32 ? 265  CYS B O   1 
ATOM   4282 C CB  . CYS B 1 265 ? -36.023 -39.408 -14.350 1.00  50.92 ? 265  CYS B CB  1 
ATOM   4283 S SG  . CYS B 1 265 ? -34.558 -39.393 -15.427 1.00  53.35 ? 265  CYS B SG  1 
ATOM   4284 N N   . PHE B 1 266 ? -34.742 -36.696 -12.307 1.00  48.69 ? 266  PHE B N   1 
ATOM   4285 C CA  . PHE B 1 266 ? -33.834 -36.355 -11.212 1.00  47.28 ? 266  PHE B CA  1 
ATOM   4286 C C   . PHE B 1 266 ? -34.477 -36.663 -9.874  1.00  46.72 ? 266  PHE B C   1 
ATOM   4287 O O   . PHE B 1 266 ? -35.655 -36.368 -9.654  1.00  46.55 ? 266  PHE B O   1 
ATOM   4288 C CB  . PHE B 1 266 ? -33.439 -34.872 -11.268 1.00  46.92 ? 266  PHE B CB  1 
ATOM   4289 C CG  . PHE B 1 266 ? -32.706 -34.481 -12.522 1.00  45.57 ? 266  PHE B CG  1 
ATOM   4290 C CD1 . PHE B 1 266 ? -33.220 -33.516 -13.367 1.00  44.73 ? 266  PHE B CD1 1 
ATOM   4291 C CD2 . PHE B 1 266 ? -31.496 -35.074 -12.855 1.00  45.21 ? 266  PHE B CD2 1 
ATOM   4292 C CE1 . PHE B 1 266 ? -32.544 -33.149 -14.529 1.00  43.53 ? 266  PHE B CE1 1 
ATOM   4293 C CE2 . PHE B 1 266 ? -30.811 -34.716 -14.015 1.00  43.66 ? 266  PHE B CE2 1 
ATOM   4294 C CZ  . PHE B 1 266 ? -31.341 -33.760 -14.851 1.00  43.65 ? 266  PHE B CZ  1 
ATOM   4295 N N   . GLU B 1 267 ? -33.709 -37.286 -8.990  1.00  46.32 ? 267  GLU B N   1 
ATOM   4296 C CA  . GLU B 1 267 ? -34.142 -37.446 -7.615  1.00  46.01 ? 267  GLU B CA  1 
ATOM   4297 C C   . GLU B 1 267 ? -34.152 -36.041 -7.032  1.00  45.55 ? 267  GLU B C   1 
ATOM   4298 O O   . GLU B 1 267 ? -35.112 -35.653 -6.384  1.00  46.01 ? 267  GLU B O   1 
ATOM   4299 C CB  . GLU B 1 267 ? -33.199 -38.370 -6.850  1.00  46.07 ? 267  GLU B CB  1 
ATOM   4300 C CG  . GLU B 1 267 ? -33.613 -38.660 -5.407  1.00  47.57 ? 267  GLU B CG  1 
ATOM   4301 C CD  . GLU B 1 267 ? -34.641 -39.785 -5.259  1.00  49.40 ? 267  GLU B CD  1 
ATOM   4302 O OE1 . GLU B 1 267 ? -34.957 -40.497 -6.253  1.00  49.75 ? 267  GLU B OE1 1 
ATOM   4303 O OE2 . GLU B 1 267 ? -35.124 -39.959 -4.118  1.00  49.24 ? 267  GLU B OE2 1 
ATOM   4304 N N   . ALA B 1 268 ? -33.093 -35.279 -7.316  1.00  45.02 ? 268  ALA B N   1 
ATOM   4305 C CA  . ALA B 1 268 ? -32.942 -33.884 -6.888  1.00  44.12 ? 268  ALA B CA  1 
ATOM   4306 C C   . ALA B 1 268 ? -31.970 -33.101 -7.791  1.00  43.39 ? 268  ALA B C   1 
ATOM   4307 O O   . ALA B 1 268 ? -31.056 -33.667 -8.387  1.00  43.56 ? 268  ALA B O   1 
ATOM   4308 C CB  . ALA B 1 268 ? -32.477 -33.826 -5.428  1.00  44.11 ? 268  ALA B CB  1 
ATOM   4309 N N   . VAL B 1 269 ? -32.183 -31.799 -7.903  1.00  42.51 ? 269  VAL B N   1 
ATOM   4310 C CA  . VAL B 1 269 ? -31.212 -30.926 -8.549  1.00  41.58 ? 269  VAL B CA  1 
ATOM   4311 C C   . VAL B 1 269 ? -30.678 -29.995 -7.469  1.00  41.24 ? 269  VAL B C   1 
ATOM   4312 O O   . VAL B 1 269 ? -31.450 -29.318 -6.784  1.00  40.94 ? 269  VAL B O   1 
ATOM   4313 C CB  . VAL B 1 269 ? -31.829 -30.097 -9.698  1.00  41.39 ? 269  VAL B CB  1 
ATOM   4314 C CG1 . VAL B 1 269 ? -30.800 -29.168 -10.296 1.00  40.87 ? 269  VAL B CG1 1 
ATOM   4315 C CG2 . VAL B 1 269 ? -32.373 -31.002 -10.774 1.00  41.67 ? 269  VAL B CG2 1 
ATOM   4316 N N   . VAL B 1 270 ? -29.359 -29.991 -7.303  1.00  40.44 ? 270  VAL B N   1 
ATOM   4317 C CA  . VAL B 1 270 ? -28.711 -29.139 -6.329  1.00  39.45 ? 270  VAL B CA  1 
ATOM   4318 C C   . VAL B 1 270 ? -27.958 -28.040 -7.050  1.00  39.24 ? 270  VAL B C   1 
ATOM   4319 O O   . VAL B 1 270 ? -27.378 -28.267 -8.112  1.00  39.25 ? 270  VAL B O   1 
ATOM   4320 C CB  . VAL B 1 270 ? -27.752 -29.954 -5.443  1.00  39.37 ? 270  VAL B CB  1 
ATOM   4321 C CG1 . VAL B 1 270 ? -26.808 -29.048 -4.671  1.00  38.90 ? 270  VAL B CG1 1 
ATOM   4322 C CG2 . VAL B 1 270 ? -28.536 -30.805 -4.494  1.00  38.86 ? 270  VAL B CG2 1 
ATOM   4323 N N   . VAL B 1 271 ? -27.991 -26.845 -6.472  1.00  39.03 ? 271  VAL B N   1 
ATOM   4324 C CA  . VAL B 1 271 ? -27.212 -25.704 -6.946  1.00  38.96 ? 271  VAL B CA  1 
ATOM   4325 C C   . VAL B 1 271 ? -26.722 -24.824 -5.796  1.00  39.60 ? 271  VAL B C   1 
ATOM   4326 O O   . VAL B 1 271 ? -27.351 -24.765 -4.725  1.00  39.88 ? 271  VAL B O   1 
ATOM   4327 C CB  . VAL B 1 271 ? -28.001 -24.819 -7.925  1.00  38.61 ? 271  VAL B CB  1 
ATOM   4328 C CG1 . VAL B 1 271 ? -28.144 -25.507 -9.244  1.00  39.11 ? 271  VAL B CG1 1 
ATOM   4329 C CG2 . VAL B 1 271 ? -29.349 -24.435 -7.372  1.00  37.65 ? 271  VAL B CG2 1 
ATOM   4330 N N   . THR B 1 272 ? -25.610 -24.126 -6.014  1.00  39.92 ? 272  THR B N   1 
ATOM   4331 C CA  . THR B 1 272 ? -25.150 -23.174 -5.018  1.00  40.48 ? 272  THR B CA  1 
ATOM   4332 C C   . THR B 1 272 ? -26.004 -21.924 -5.186  1.00  41.01 ? 272  THR B C   1 
ATOM   4333 O O   . THR B 1 272 ? -26.747 -21.804 -6.168  1.00  41.02 ? 272  THR B O   1 
ATOM   4334 C CB  . THR B 1 272 ? -23.663 -22.798 -5.182  1.00  40.51 ? 272  THR B CB  1 
ATOM   4335 O OG1 . THR B 1 272 ? -23.523 -21.971 -6.337  1.00  40.46 ? 272  THR B OG1 1 
ATOM   4336 C CG2 . THR B 1 272 ? -22.749 -24.041 -5.308  1.00  39.87 ? 272  THR B CG2 1 
ATOM   4337 N N   . ASN B 1 273 ? -25.912 -20.992 -4.242  1.00  41.56 ? 273  ASN B N   1 
ATOM   4338 C CA  . ASN B 1 273 ? -26.616 -19.723 -4.417  1.00  42.30 ? 273  ASN B CA  1 
ATOM   4339 C C   . ASN B 1 273 ? -25.774 -18.609 -5.082  1.00  42.82 ? 273  ASN B C   1 
ATOM   4340 O O   . ASN B 1 273 ? -26.059 -17.419 -4.893  1.00  42.60 ? 273  ASN B O   1 
ATOM   4341 C CB  . ASN B 1 273 ? -27.275 -19.254 -3.114  1.00  41.96 ? 273  ASN B CB  1 
ATOM   4342 C CG  . ASN B 1 273 ? -26.295 -19.118 -1.975  1.00  42.40 ? 273  ASN B CG  1 
ATOM   4343 O OD1 . ASN B 1 273 ? -25.174 -19.626 -2.033  1.00  42.94 ? 273  ASN B OD1 1 
ATOM   4344 N ND2 . ASN B 1 273 ? -26.721 -18.440 -0.917  1.00  43.40 ? 273  ASN B ND2 1 
ATOM   4345 N N   . THR B 1 274 ? -24.765 -19.002 -5.873  1.00  43.54 ? 274  THR B N   1 
ATOM   4346 C CA  . THR B 1 274 ? -23.970 -18.047 -6.667  1.00  44.35 ? 274  THR B CA  1 
ATOM   4347 C C   . THR B 1 274 ? -24.887 -17.193 -7.528  1.00  45.23 ? 274  THR B C   1 
ATOM   4348 O O   . THR B 1 274 ? -24.525 -16.093 -7.934  1.00  45.36 ? 274  THR B O   1 
ATOM   4349 C CB  . THR B 1 274 ? -22.922 -18.724 -7.601  1.00  44.16 ? 274  THR B CB  1 
ATOM   4350 O OG1 . THR B 1 274 ? -23.569 -19.632 -8.500  1.00  43.17 ? 274  THR B OG1 1 
ATOM   4351 C CG2 . THR B 1 274 ? -21.839 -19.456 -6.806  1.00  44.40 ? 274  THR B CG2 1 
ATOM   4352 N N   . ILE B 1 275 ? -26.074 -17.723 -7.803  1.00  46.50 ? 275  ILE B N   1 
ATOM   4353 C CA  . ILE B 1 275 ? -27.126 -17.032 -8.545  1.00  47.64 ? 275  ILE B CA  1 
ATOM   4354 C C   . ILE B 1 275 ? -28.431 -17.308 -7.796  1.00  48.48 ? 275  ILE B C   1 
ATOM   4355 O O   . ILE B 1 275 ? -28.690 -18.459 -7.417  1.00  48.50 ? 275  ILE B O   1 
ATOM   4356 C CB  . ILE B 1 275 ? -27.193 -17.516 -10.031 1.00  47.70 ? 275  ILE B CB  1 
ATOM   4357 C CG1 . ILE B 1 275 ? -25.923 -17.084 -10.803 1.00  48.16 ? 275  ILE B CG1 1 
ATOM   4358 C CG2 . ILE B 1 275 ? -28.465 -17.008 -10.721 1.00  48.39 ? 275  ILE B CG2 1 
ATOM   4359 C CD1 . ILE B 1 275 ? -25.988 -17.179 -12.354 1.00  47.56 ? 275  ILE B CD1 1 
ATOM   4360 N N   . PRO B 1 276 ? -29.249 -16.258 -7.559  1.00  49.52 ? 276  PRO B N   1 
ATOM   4361 C CA  . PRO B 1 276 ? -30.407 -16.378 -6.642  1.00  50.31 ? 276  PRO B CA  1 
ATOM   4362 C C   . PRO B 1 276 ? -31.431 -17.396 -7.138  1.00  51.15 ? 276  PRO B C   1 
ATOM   4363 O O   . PRO B 1 276 ? -31.826 -17.352 -8.309  1.00  51.36 ? 276  PRO B O   1 
ATOM   4364 C CB  . PRO B 1 276 ? -31.003 -14.960 -6.617  1.00  50.20 ? 276  PRO B CB  1 
ATOM   4365 C CG  . PRO B 1 276 ? -30.466 -14.275 -7.840  1.00  49.72 ? 276  PRO B CG  1 
ATOM   4366 C CD  . PRO B 1 276 ? -29.126 -14.901 -8.123  1.00  49.54 ? 276  PRO B CD  1 
ATOM   4367 N N   . GLN B 1 277 ? -31.830 -18.311 -6.248  1.00  52.04 ? 277  GLN B N   1 
ATOM   4368 C CA  . GLN B 1 277 ? -32.680 -19.455 -6.610  1.00  52.87 ? 277  GLN B CA  1 
ATOM   4369 C C   . GLN B 1 277 ? -34.067 -19.396 -5.980  1.00  53.08 ? 277  GLN B C   1 
ATOM   4370 O O   . GLN B 1 277 ? -35.001 -20.041 -6.461  1.00  52.87 ? 277  GLN B O   1 
ATOM   4371 C CB  . GLN B 1 277 ? -32.016 -20.779 -6.203  1.00  52.92 ? 277  GLN B CB  1 
ATOM   4372 C CG  . GLN B 1 277 ? -30.552 -20.916 -6.575  1.00  54.74 ? 277  GLN B CG  1 
ATOM   4373 C CD  . GLN B 1 277 ? -30.288 -20.994 -8.082  1.00  57.54 ? 277  GLN B CD  1 
ATOM   4374 O OE1 . GLN B 1 277 ? -29.191 -20.652 -8.532  1.00  59.49 ? 277  GLN B OE1 1 
ATOM   4375 N NE2 . GLN B 1 277 ? -31.274 -21.462 -8.859  1.00  57.30 ? 277  GLN B NE2 1 
ATOM   4376 N N   . GLU B 1 278 ? -34.181 -18.626 -4.898  0.20  53.59 ? 278  GLU B N   1 
ATOM   4377 C CA  . GLU B 1 278 ? -35.395 -18.549 -4.076  0.20  54.20 ? 278  GLU B CA  1 
ATOM   4378 C C   . GLU B 1 278 ? -36.697 -18.585 -4.879  0.20  54.79 ? 278  GLU B C   1 
ATOM   4379 O O   . GLU B 1 278 ? -37.623 -19.319 -4.536  0.20  54.86 ? 278  GLU B O   1 
ATOM   4380 C CB  . GLU B 1 278 ? -35.354 -17.300 -3.188  0.20  54.08 ? 278  GLU B CB  1 
ATOM   4381 C CG  . GLU B 1 278 ? -34.087 -17.183 -2.347  0.20  54.01 ? 278  GLU B CG  1 
ATOM   4382 C CD  . GLU B 1 278 ? -32.837 -16.989 -3.189  0.20  53.86 ? 278  GLU B CD  1 
ATOM   4383 O OE1 . GLU B 1 278 ? -32.747 -15.963 -3.897  0.20  53.89 ? 278  GLU B OE1 1 
ATOM   4384 O OE2 . GLU B 1 278 ? -31.939 -17.857 -3.133  0.20  53.66 ? 278  GLU B OE2 1 
ATOM   4385 N N   . ASP B 1 279 ? -36.745 -17.795 -5.948  0.96  55.65 ? 279  ASP B N   1 
ATOM   4386 C CA  . ASP B 1 279 ? -37.903 -17.729 -6.850  0.96  56.89 ? 279  ASP B CA  1 
ATOM   4387 C C   . ASP B 1 279 ? -38.080 -19.017 -7.670  0.96  57.08 ? 279  ASP B C   1 
ATOM   4388 O O   . ASP B 1 279 ? -39.195 -19.539 -7.786  0.96  57.29 ? 279  ASP B O   1 
ATOM   4389 C CB  . ASP B 1 279 ? -37.788 -16.489 -7.775  0.96  57.27 ? 279  ASP B CB  1 
ATOM   4390 C CG  . ASP B 1 279 ? -38.996 -16.314 -8.725  0.96  58.75 ? 279  ASP B CG  1 
ATOM   4391 O OD1 . ASP B 1 279 ? -38.791 -15.788 -9.849  0.96  58.75 ? 279  ASP B OD1 1 
ATOM   4392 O OD2 . ASP B 1 279 ? -40.141 -16.684 -8.354  0.96  60.73 ? 279  ASP B OD2 1 
ATOM   4393 N N   . LYS B 1 280 ? -36.981 -19.513 -8.238  1.00  57.57 ? 280  LYS B N   1 
ATOM   4394 C CA  . LYS B 1 280 ? -36.982 -20.750 -9.039  1.00  58.00 ? 280  LYS B CA  1 
ATOM   4395 C C   . LYS B 1 280 ? -37.412 -21.959 -8.193  1.00  58.29 ? 280  LYS B C   1 
ATOM   4396 O O   . LYS B 1 280 ? -37.967 -22.933 -8.709  1.00  58.51 ? 280  LYS B O   1 
ATOM   4397 C CB  . LYS B 1 280 ? -35.589 -21.007 -9.646  1.00  58.01 ? 280  LYS B CB  1 
ATOM   4398 C CG  . LYS B 1 280 ? -35.034 -19.889 -10.547 1.00  58.08 ? 280  LYS B CG  1 
ATOM   4399 C CD  . LYS B 1 280 ? -35.574 -19.979 -11.973 1.00  58.47 ? 280  LYS B CD  1 
ATOM   4400 C CE  . LYS B 1 280 ? -35.365 -18.682 -12.756 1.00  57.86 ? 280  LYS B CE  1 
ATOM   4401 N NZ  . LYS B 1 280 ? -34.020 -18.623 -13.403 1.00  57.80 ? 280  LYS B NZ  1 
ATOM   4402 N N   . MET B 1 281 ? -37.147 -21.881 -6.892  1.00  58.63 ? 281  MET B N   1 
ATOM   4403 C CA  . MET B 1 281 ? -37.486 -22.949 -5.967  1.00  58.97 ? 281  MET B CA  1 
ATOM   4404 C C   . MET B 1 281 ? -39.004 -23.082 -5.857  1.00  59.11 ? 281  MET B C   1 
ATOM   4405 O O   . MET B 1 281 ? -39.559 -24.166 -6.057  1.00  59.13 ? 281  MET B O   1 
ATOM   4406 C CB  . MET B 1 281 ? -36.825 -22.705 -4.600  1.00  59.12 ? 281  MET B CB  1 
ATOM   4407 C CG  . MET B 1 281 ? -35.291 -22.881 -4.615  1.00  59.44 ? 281  MET B CG  1 
ATOM   4408 S SD  . MET B 1 281 ? -34.407 -22.068 -3.259  1.00  60.21 ? 281  MET B SD  1 
ATOM   4409 C CE  . MET B 1 281 ? -34.803 -23.153 -1.884  1.00  60.76 ? 281  MET B CE  1 
ATOM   4410 N N   . LYS B 1 282 ? -39.672 -21.968 -5.574  0.99  59.45 ? 282  LYS B N   1 
ATOM   4411 C CA  . LYS B 1 282 ? -41.140 -21.919 -5.475  0.99  59.93 ? 282  LYS B CA  1 
ATOM   4412 C C   . LYS B 1 282 ? -41.874 -22.678 -6.600  0.99  59.87 ? 282  LYS B C   1 
ATOM   4413 O O   . LYS B 1 282 ? -42.864 -23.361 -6.334  0.99  60.29 ? 282  LYS B O   1 
ATOM   4414 C CB  . LYS B 1 282 ? -41.623 -20.461 -5.391  0.99  60.24 ? 282  LYS B CB  1 
ATOM   4415 C CG  . LYS B 1 282 ? -40.847 -19.611 -4.368  0.99  61.36 ? 282  LYS B CG  1 
ATOM   4416 C CD  . LYS B 1 282 ? -41.275 -18.141 -4.357  0.99  63.36 ? 282  LYS B CD  1 
ATOM   4417 C CE  . LYS B 1 282 ? -40.557 -17.394 -3.210  0.99  64.13 ? 282  LYS B CE  1 
ATOM   4418 N NZ  . LYS B 1 282 ? -41.042 -15.987 -3.024  0.99  63.51 ? 282  LYS B NZ  1 
ATOM   4419 N N   . HIS B 1 283 ? -41.377 -22.566 -7.836  1.00  59.56 ? 283  HIS B N   1 
ATOM   4420 C CA  . HIS B 1 283 ? -41.879 -23.358 -8.972  1.00  59.35 ? 283  HIS B CA  1 
ATOM   4421 C C   . HIS B 1 283 ? -41.225 -24.756 -9.127  1.00  58.54 ? 283  HIS B C   1 
ATOM   4422 O O   . HIS B 1 283 ? -41.644 -25.553 -9.982  1.00  58.43 ? 283  HIS B O   1 
ATOM   4423 C CB  . HIS B 1 283 ? -41.721 -22.581 -10.291 1.00  59.81 ? 283  HIS B CB  1 
ATOM   4424 C CG  . HIS B 1 283 ? -42.469 -21.282 -10.335 1.00  62.02 ? 283  HIS B CG  1 
ATOM   4425 N ND1 . HIS B 1 283 ? -43.810 -21.175 -10.026 1.00  64.21 ? 283  HIS B ND1 1 
ATOM   4426 C CD2 . HIS B 1 283 ? -42.064 -20.036 -10.682 1.00  64.35 ? 283  HIS B CD2 1 
ATOM   4427 C CE1 . HIS B 1 283 ? -44.194 -19.916 -10.160 1.00  64.65 ? 283  HIS B CE1 1 
ATOM   4428 N NE2 . HIS B 1 283 ? -43.154 -19.205 -10.560 1.00  65.15 ? 283  HIS B NE2 1 
ATOM   4429 N N   . CYS B 1 284 ? -40.203 -25.046 -8.319  1.00  57.39 ? 284  CYS B N   1 
ATOM   4430 C CA  . CYS B 1 284 ? -39.468 -26.312 -8.441  1.00  56.37 ? 284  CYS B CA  1 
ATOM   4431 C C   . CYS B 1 284 ? -39.037 -26.917 -7.087  1.00  55.37 ? 284  CYS B C   1 
ATOM   4432 O O   . CYS B 1 284 ? -38.109 -26.432 -6.418  1.00  55.14 ? 284  CYS B O   1 
ATOM   4433 C CB  . CYS B 1 284 ? -38.271 -26.160 -9.388  1.00  56.34 ? 284  CYS B CB  1 
ATOM   4434 S SG  . CYS B 1 284 ? -37.567 -27.746 -9.908  1.00  57.35 ? 284  CYS B SG  1 
ATOM   4435 N N   . SER B 1 285 ? -39.720 -27.993 -6.703  1.00  53.97 ? 285  SER B N   1 
ATOM   4436 C CA  . SER B 1 285 ? -39.500 -28.645 -5.409  1.00  52.39 ? 285  SER B CA  1 
ATOM   4437 C C   . SER B 1 285 ? -38.315 -29.615 -5.407  1.00  51.15 ? 285  SER B C   1 
ATOM   4438 O O   . SER B 1 285 ? -37.965 -30.174 -4.355  1.00  50.83 ? 285  SER B O   1 
ATOM   4439 C CB  . SER B 1 285 ? -40.779 -29.353 -4.947  1.00  52.49 ? 285  SER B CB  1 
ATOM   4440 O OG  . SER B 1 285 ? -41.493 -29.918 -6.036  1.00  52.90 ? 285  SER B OG  1 
ATOM   4441 N N   . LYS B 1 286 ? -37.714 -29.806 -6.586  1.00  49.50 ? 286  LYS B N   1 
ATOM   4442 C CA  . LYS B 1 286 ? -36.528 -30.643 -6.753  1.00  47.88 ? 286  LYS B CA  1 
ATOM   4443 C C   . LYS B 1 286 ? -35.252 -29.896 -6.379  1.00  46.86 ? 286  LYS B C   1 
ATOM   4444 O O   . LYS B 1 286 ? -34.205 -30.509 -6.089  1.00  46.56 ? 286  LYS B O   1 
ATOM   4445 C CB  . LYS B 1 286 ? -36.425 -31.118 -8.197  1.00  47.86 ? 286  LYS B CB  1 
ATOM   4446 C CG  . LYS B 1 286 ? -37.457 -32.147 -8.565  1.00  48.02 ? 286  LYS B CG  1 
ATOM   4447 C CD  . LYS B 1 286 ? -36.899 -33.114 -9.582  1.00  48.62 ? 286  LYS B CD  1 
ATOM   4448 C CE  . LYS B 1 286 ? -37.971 -34.056 -10.079 1.00  48.88 ? 286  LYS B CE  1 
ATOM   4449 N NZ  . LYS B 1 286 ? -38.666 -33.493 -11.263 1.00  49.67 ? 286  LYS B NZ  1 
ATOM   4450 N N   . ILE B 1 287 ? -35.344 -28.569 -6.388  1.00  45.55 ? 287  ILE B N   1 
ATOM   4451 C CA  . ILE B 1 287 ? -34.173 -27.724 -6.184  1.00  44.37 ? 287  ILE B CA  1 
ATOM   4452 C C   . ILE B 1 287 ? -33.760 -27.548 -4.711  1.00  43.30 ? 287  ILE B C   1 
ATOM   4453 O O   . ILE B 1 287 ? -34.530 -27.070 -3.879  1.00  43.14 ? 287  ILE B O   1 
ATOM   4454 C CB  . ILE B 1 287 ? -34.290 -26.380 -6.945  1.00  44.27 ? 287  ILE B CB  1 
ATOM   4455 C CG1 . ILE B 1 287 ? -34.350 -26.665 -8.454  1.00  44.58 ? 287  ILE B CG1 1 
ATOM   4456 C CG2 . ILE B 1 287 ? -33.098 -25.473 -6.604  1.00  44.40 ? 287  ILE B CG2 1 
ATOM   4457 C CD1 . ILE B 1 287 ? -34.382 -25.436 -9.353  1.00  46.41 ? 287  ILE B CD1 1 
ATOM   4458 N N   . GLN B 1 288 ? -32.540 -27.982 -4.412  1.00  42.31 ? 288  GLN B N   1 
ATOM   4459 C CA  . GLN B 1 288 ? -31.918 -27.757 -3.113  1.00  41.48 ? 288  GLN B CA  1 
ATOM   4460 C C   . GLN B 1 288 ? -30.772 -26.765 -3.274  1.00  40.96 ? 288  GLN B C   1 
ATOM   4461 O O   . GLN B 1 288 ? -30.185 -26.652 -4.357  1.00  40.98 ? 288  GLN B O   1 
ATOM   4462 C CB  . GLN B 1 288 ? -31.466 -29.072 -2.493  1.00  41.24 ? 288  GLN B CB  1 
ATOM   4463 C CG  . GLN B 1 288 ? -32.644 -30.016 -2.237  1.00  41.74 ? 288  GLN B CG  1 
ATOM   4464 C CD  . GLN B 1 288 ? -32.255 -31.272 -1.484  1.00  42.99 ? 288  GLN B CD  1 
ATOM   4465 O OE1 . GLN B 1 288 ? -32.503 -32.389 -1.944  1.00  43.55 ? 288  GLN B OE1 1 
ATOM   4466 N NE2 . GLN B 1 288 ? -31.633 -31.098 -0.321  1.00  43.57 ? 288  GLN B NE2 1 
ATOM   4467 N N   . VAL B 1 289 ? -30.483 -26.017 -2.213  1.00  40.15 ? 289  VAL B N   1 
ATOM   4468 C CA  . VAL B 1 289 ? -29.572 -24.873 -2.326  1.00  39.30 ? 289  VAL B CA  1 
ATOM   4469 C C   . VAL B 1 289 ? -28.456 -24.902 -1.290  1.00  38.83 ? 289  VAL B C   1 
ATOM   4470 O O   . VAL B 1 289 ? -28.716 -24.818 -0.081  1.00  38.77 ? 289  VAL B O   1 
ATOM   4471 C CB  . VAL B 1 289 ? -30.354 -23.533 -2.244  1.00  39.10 ? 289  VAL B CB  1 
ATOM   4472 C CG1 . VAL B 1 289 ? -29.469 -22.393 -1.767  1.00  39.04 ? 289  VAL B CG1 1 
ATOM   4473 C CG2 . VAL B 1 289 ? -30.958 -23.197 -3.580  1.00  38.96 ? 289  VAL B CG2 1 
ATOM   4474 N N   . ILE B 1 290 ? -27.227 -25.037 -1.774  1.00  38.15 ? 290  ILE B N   1 
ATOM   4475 C CA  . ILE B 1 290 ? -26.064 -24.913 -0.922  1.00  37.96 ? 290  ILE B CA  1 
ATOM   4476 C C   . ILE B 1 290 ? -25.771 -23.426 -0.791  1.00  37.67 ? 290  ILE B C   1 
ATOM   4477 O O   . ILE B 1 290 ? -25.783 -22.695 -1.784  1.00  37.74 ? 290  ILE B O   1 
ATOM   4478 C CB  . ILE B 1 290 ? -24.834 -25.631 -1.501  1.00  37.98 ? 290  ILE B CB  1 
ATOM   4479 C CG1 . ILE B 1 290 ? -25.231 -26.978 -2.101  1.00  37.79 ? 290  ILE B CG1 1 
ATOM   4480 C CG2 . ILE B 1 290 ? -23.780 -25.796 -0.422  1.00  38.32 ? 290  ILE B CG2 1 
ATOM   4481 C CD1 . ILE B 1 290 ? -24.107 -27.684 -2.815  1.00  39.05 ? 290  ILE B CD1 1 
ATOM   4482 N N   . ASP B 1 291 ? -25.522 -22.992 0.442   1.00  37.56 ? 291  ASP B N   1 
ATOM   4483 C CA  . ASP B 1 291 ? -25.240 -21.598 0.769   1.00  37.43 ? 291  ASP B CA  1 
ATOM   4484 C C   . ASP B 1 291 ? -23.730 -21.341 0.668   1.00  37.07 ? 291  ASP B C   1 
ATOM   4485 O O   . ASP B 1 291 ? -22.949 -21.891 1.437   1.00  36.89 ? 291  ASP B O   1 
ATOM   4486 C CB  . ASP B 1 291 ? -25.745 -21.327 2.189   1.00  37.66 ? 291  ASP B CB  1 
ATOM   4487 C CG  . ASP B 1 291 ? -25.425 -19.923 2.692   1.00  39.81 ? 291  ASP B CG  1 
ATOM   4488 O OD1 . ASP B 1 291 ? -24.877 -19.090 1.913   1.00  42.31 ? 291  ASP B OD1 1 
ATOM   4489 O OD2 . ASP B 1 291 ? -25.730 -19.653 3.888   1.00  40.14 ? 291  ASP B OD2 1 
ATOM   4490 N N   . ILE B 1 292 ? -23.311 -20.509 -0.276  1.00  36.71 ? 292  ILE B N   1 
ATOM   4491 C CA  . ILE B 1 292 ? -21.881 -20.283 -0.455  1.00  37.01 ? 292  ILE B CA  1 
ATOM   4492 C C   . ILE B 1 292 ? -21.348 -18.953 0.112   1.00  37.10 ? 292  ILE B C   1 
ATOM   4493 O O   . ILE B 1 292 ? -20.189 -18.586 -0.130  1.00  37.28 ? 292  ILE B O   1 
ATOM   4494 C CB  . ILE B 1 292 ? -21.412 -20.507 -1.919  1.00  37.00 ? 292  ILE B CB  1 
ATOM   4495 C CG1 . ILE B 1 292 ? -22.250 -19.686 -2.915  1.00  37.55 ? 292  ILE B CG1 1 
ATOM   4496 C CG2 . ILE B 1 292 ? -21.455 -21.986 -2.262  1.00  37.29 ? 292  ILE B CG2 1 
ATOM   4497 C CD1 . ILE B 1 292 ? -21.866 -18.196 -3.017  1.00  36.46 ? 292  ILE B CD1 1 
ATOM   4498 N N   . SER B 1 293 ? -22.178 -18.265 0.893   1.00  36.76 ? 293  SER B N   1 
ATOM   4499 C CA  . SER B 1 293 ? -21.781 -17.007 1.512   1.00  36.44 ? 293  SER B CA  1 
ATOM   4500 C C   . SER B 1 293 ? -20.747 -17.176 2.626   1.00  36.45 ? 293  SER B C   1 
ATOM   4501 O O   . SER B 1 293 ? -19.974 -16.239 2.908   1.00  36.30 ? 293  SER B O   1 
ATOM   4502 C CB  . SER B 1 293 ? -23.003 -16.245 2.043   1.00  36.77 ? 293  SER B CB  1 
ATOM   4503 O OG  . SER B 1 293 ? -23.790 -17.050 2.907   1.00  35.74 ? 293  SER B OG  1 
ATOM   4504 N N   . MET B 1 294 ? -20.740 -18.334 3.288   0.80  36.23 ? 294  MET B N   1 
ATOM   4505 C CA  . MET B 1 294 ? -19.708 -18.566 4.296   0.80  36.36 ? 294  MET B CA  1 
ATOM   4506 C C   . MET B 1 294 ? -18.348 -18.737 3.606   0.80  35.54 ? 294  MET B C   1 
ATOM   4507 O O   . MET B 1 294 ? -17.320 -18.340 4.154   0.80  35.53 ? 294  MET B O   1 
ATOM   4508 C CB  . MET B 1 294 ? -20.033 -19.769 5.192   0.80  36.58 ? 294  MET B CB  1 
ATOM   4509 C CG  . MET B 1 294 ? -19.623 -21.115 4.603   0.80  39.43 ? 294  MET B CG  1 
ATOM   4510 S SD  . MET B 1 294 ? -20.648 -21.596 3.198   0.80  43.87 ? 294  MET B SD  1 
ATOM   4511 C CE  . MET B 1 294 ? -21.850 -22.646 4.072   0.80  43.94 ? 294  MET B CE  1 
ATOM   4512 N N   . ILE B 1 295 ? -18.354 -19.315 2.403   1.00  34.63 ? 295  ILE B N   1 
ATOM   4513 C CA  . ILE B 1 295 ? -17.116 -19.456 1.629   1.00  33.87 ? 295  ILE B CA  1 
ATOM   4514 C C   . ILE B 1 295 ? -16.617 -18.087 1.169   1.00  33.58 ? 295  ILE B C   1 
ATOM   4515 O O   . ILE B 1 295 ? -15.428 -17.731 1.395   1.00  33.58 ? 295  ILE B O   1 
ATOM   4516 C CB  . ILE B 1 295 ? -17.262 -20.440 0.437   1.00  33.54 ? 295  ILE B CB  1 
ATOM   4517 C CG1 . ILE B 1 295 ? -17.593 -21.843 0.996   1.00  33.63 ? 295  ILE B CG1 1 
ATOM   4518 C CG2 . ILE B 1 295 ? -15.946 -20.513 -0.343  1.00  32.29 ? 295  ILE B CG2 1 
ATOM   4519 C CD1 . ILE B 1 295 ? -18.708 -22.577 0.212   1.00  32.67 ? 295  ILE B CD1 1 
ATOM   4520 N N   . LEU B 1 296 ? -17.534 -17.310 0.577   1.00  32.88 ? 296  LEU B N   1 
ATOM   4521 C CA  . LEU B 1 296 ? -17.201 -15.997 0.056   1.00  32.32 ? 296  LEU B CA  1 
ATOM   4522 C C   . LEU B 1 296 ? -16.727 -15.037 1.143   1.00  32.22 ? 296  LEU B C   1 
ATOM   4523 O O   . LEU B 1 296 ? -15.687 -14.409 1.004   1.00  32.47 ? 296  LEU B O   1 
ATOM   4524 C CB  . LEU B 1 296 ? -18.367 -15.424 -0.756  1.00  32.13 ? 296  LEU B CB  1 
ATOM   4525 C CG  . LEU B 1 296 ? -18.689 -16.152 -2.075  1.00  31.54 ? 296  LEU B CG  1 
ATOM   4526 C CD1 . LEU B 1 296 ? -19.699 -15.396 -2.857  1.00  29.88 ? 296  LEU B CD1 1 
ATOM   4527 C CD2 . LEU B 1 296 ? -17.472 -16.402 -2.934  1.00  32.49 ? 296  LEU B CD2 1 
ATOM   4528 N N   . ALA B 1 297 ? -17.477 -14.948 2.232   1.00  32.45 ? 297  ALA B N   1 
ATOM   4529 C CA  . ALA B 1 297 ? -17.128 -14.073 3.355   1.00  32.09 ? 297  ALA B CA  1 
ATOM   4530 C C   . ALA B 1 297 ? -15.734 -14.371 3.861   1.00  31.96 ? 297  ALA B C   1 
ATOM   4531 O O   . ALA B 1 297 ? -14.925 -13.452 4.015   1.00  32.29 ? 297  ALA B O   1 
ATOM   4532 C CB  . ALA B 1 297 ? -18.135 -14.223 4.485   1.00  32.15 ? 297  ALA B CB  1 
ATOM   4533 N N   . GLU B 1 298 ? -15.464 -15.656 4.111   0.50  31.60 ? 298  GLU B N   1 
ATOM   4534 C CA  . GLU B 1 298 ? -14.167 -16.117 4.587   0.50  31.23 ? 298  GLU B CA  1 
ATOM   4535 C C   . GLU B 1 298 ? -13.058 -15.736 3.624   0.50  31.09 ? 298  GLU B C   1 
ATOM   4536 O O   . GLU B 1 298 ? -11.988 -15.340 4.044   0.50  31.00 ? 298  GLU B O   1 
ATOM   4537 C CB  . GLU B 1 298 ? -14.184 -17.628 4.795   0.50  31.15 ? 298  GLU B CB  1 
ATOM   4538 C CG  . GLU B 1 298 ? -13.008 -18.152 5.594   0.50  32.04 ? 298  GLU B CG  1 
ATOM   4539 C CD  . GLU B 1 298 ? -13.114 -17.826 7.072   0.50  32.06 ? 298  GLU B CD  1 
ATOM   4540 O OE1 . GLU B 1 298 ? -14.252 -17.633 7.551   0.50  31.69 ? 298  GLU B OE1 1 
ATOM   4541 O OE2 . GLU B 1 298 ? -12.062 -17.757 7.748   0.50  31.99 ? 298  GLU B OE2 1 
ATOM   4542 N N   . ALA B 1 299 ? -13.334 -15.846 2.330   1.00  31.55 ? 299  ALA B N   1 
ATOM   4543 C CA  . ALA B 1 299 ? -12.380 -15.472 1.295   1.00  31.51 ? 299  ALA B CA  1 
ATOM   4544 C C   . ALA B 1 299 ? -12.074 -13.972 1.331   1.00  31.86 ? 299  ALA B C   1 
ATOM   4545 O O   . ALA B 1 299 ? -10.921 -13.583 1.170   1.00  32.54 ? 299  ALA B O   1 
ATOM   4546 C CB  . ALA B 1 299 ? -12.882 -15.895 -0.059  1.00  30.95 ? 299  ALA B CB  1 
ATOM   4547 N N   . ILE B 1 300 ? -13.095 -13.147 1.562   1.00  31.93 ? 300  ILE B N   1 
ATOM   4548 C CA  . ILE B 1 300 ? -12.909 -11.708 1.746   1.00  32.15 ? 300  ILE B CA  1 
ATOM   4549 C C   . ILE B 1 300 ? -12.158 -11.414 3.032   1.00  32.84 ? 300  ILE B C   1 
ATOM   4550 O O   . ILE B 1 300 ? -11.217 -10.622 3.051   1.00  32.83 ? 300  ILE B O   1 
ATOM   4551 C CB  . ILE B 1 300 ? -14.248 -10.956 1.768   1.00  31.79 ? 300  ILE B CB  1 
ATOM   4552 C CG1 . ILE B 1 300 ? -14.928 -11.087 0.401   1.00  30.64 ? 300  ILE B CG1 1 
ATOM   4553 C CG2 . ILE B 1 300 ? -14.027 -9.490  2.161   1.00  31.29 ? 300  ILE B CG2 1 
ATOM   4554 C CD1 . ILE B 1 300 ? -16.467 -11.031 0.459   1.00  29.10 ? 300  ILE B CD1 1 
ATOM   4555 N N   . ARG B 1 301 ? -12.594 -12.053 4.105   1.00  34.16 ? 301  ARG B N   1 
ATOM   4556 C CA  . ARG B 1 301 ? -11.960 -11.906 5.410   1.00  35.66 ? 301  ARG B CA  1 
ATOM   4557 C C   . ARG B 1 301 ? -10.459 -12.203 5.332   1.00  36.31 ? 301  ARG B C   1 
ATOM   4558 O O   . ARG B 1 301 ? -9.681  -11.488 5.942   1.00  37.04 ? 301  ARG B O   1 
ATOM   4559 C CB  . ARG B 1 301 ? -12.656 -12.819 6.417   1.00  35.60 ? 301  ARG B CB  1 
ATOM   4560 C CG  . ARG B 1 301 ? -12.208 -12.677 7.857   1.00  38.47 ? 301  ARG B CG  1 
ATOM   4561 C CD  . ARG B 1 301 ? -12.695 -13.896 8.684   1.00  41.67 ? 301  ARG B CD  1 
ATOM   4562 N NE  . ARG B 1 301 ? -11.819 -14.181 9.823   1.00  43.10 ? 301  ARG B NE  1 
ATOM   4563 C CZ  . ARG B 1 301 ? -10.702 -14.909 9.760   1.00  45.72 ? 301  ARG B CZ  1 
ATOM   4564 N NH1 . ARG B 1 301 ? -10.293 -15.459 8.611   1.00  45.70 ? 301  ARG B NH1 1 
ATOM   4565 N NH2 . ARG B 1 301 ? -9.991  -15.102 10.866  1.00  47.08 ? 301  ARG B NH2 1 
ATOM   4566 N N   . ARG B 1 302 ? -10.062 -13.231 4.571   0.70  36.82 ? 302  ARG B N   1 
ATOM   4567 C CA  . ARG B 1 302 ? -8.657  -13.639 4.482   0.70  37.28 ? 302  ARG B CA  1 
ATOM   4568 C C   . ARG B 1 302 ? -7.895  -12.679 3.593   0.70  37.62 ? 302  ARG B C   1 
ATOM   4569 O O   . ARG B 1 302 ? -6.858  -12.156 4.001   0.70  37.69 ? 302  ARG B O   1 
ATOM   4570 C CB  . ARG B 1 302 ? -8.514  -15.061 3.948   0.70  37.51 ? 302  ARG B CB  1 
ATOM   4571 C CG  . ARG B 1 302 ? -9.419  -16.080 4.598   0.70  38.97 ? 302  ARG B CG  1 
ATOM   4572 C CD  . ARG B 1 302 ? -8.671  -17.012 5.509   0.70  41.81 ? 302  ARG B CD  1 
ATOM   4573 N NE  . ARG B 1 302 ? -9.591  -17.945 6.156   0.70  43.54 ? 302  ARG B NE  1 
ATOM   4574 C CZ  . ARG B 1 302 ? -9.211  -19.081 6.756   0.70  44.11 ? 302  ARG B CZ  1 
ATOM   4575 N NH1 . ARG B 1 302 ? -7.918  -19.464 6.793   0.70  44.36 ? 302  ARG B NH1 1 
ATOM   4576 N NH2 . ARG B 1 302 ? -10.136 -19.845 7.319   0.70  45.38 ? 302  ARG B NH2 1 
ATOM   4577 N N   . THR B 1 303 ? -8.413  -12.467 2.376   1.00  38.21 ? 303  THR B N   1 
ATOM   4578 C CA  . THR B 1 303 ? -7.958  -11.407 1.454   1.00  38.55 ? 303  THR B CA  1 
ATOM   4579 C C   . THR B 1 303 ? -7.546  -10.128 2.198   1.00  38.99 ? 303  THR B C   1 
ATOM   4580 O O   . THR B 1 303 ? -6.429  -9.656  2.042   1.00  39.24 ? 303  THR B O   1 
ATOM   4581 C CB  . THR B 1 303 ? -9.066  -11.044 0.436   1.00  38.23 ? 303  THR B CB  1 
ATOM   4582 O OG1 . THR B 1 303 ? -9.289  -12.153 -0.441  1.00  39.55 ? 303  THR B OG1 1 
ATOM   4583 C CG2 . THR B 1 303 ? -8.682  -9.837  -0.404  1.00  38.39 ? 303  THR B CG2 1 
ATOM   4584 N N   . HIS B 1 304 ? -8.451  -9.593  3.017   1.00  39.52 ? 304  HIS B N   1 
ATOM   4585 C CA  . HIS B 1 304 ? -8.210  -8.370  3.775   1.00  40.02 ? 304  HIS B CA  1 
ATOM   4586 C C   . HIS B 1 304 ? -7.137  -8.491  4.866   1.00  40.50 ? 304  HIS B C   1 
ATOM   4587 O O   . HIS B 1 304 ? -6.384  -7.546  5.088   1.00  40.99 ? 304  HIS B O   1 
ATOM   4588 C CB  . HIS B 1 304 ? -9.513  -7.872  4.394   1.00  39.86 ? 304  HIS B CB  1 
ATOM   4589 C CG  . HIS B 1 304 ? -9.362  -6.608  5.179   1.00  39.53 ? 304  HIS B CG  1 
ATOM   4590 N ND1 . HIS B 1 304 ? -9.082  -5.395  4.585   1.00  39.03 ? 304  HIS B ND1 1 
ATOM   4591 C CD2 . HIS B 1 304 ? -9.456  -6.368  6.511   1.00  38.68 ? 304  HIS B CD2 1 
ATOM   4592 C CE1 . HIS B 1 304 ? -9.007  -4.461  5.518   1.00  39.33 ? 304  HIS B CE1 1 
ATOM   4593 N NE2 . HIS B 1 304 ? -9.231  -5.025  6.695   1.00  38.07 ? 304  HIS B NE2 1 
ATOM   4594 N N   . ASN B 1 305 ? -7.083  -9.629  5.554   1.00  40.74 ? 305  ASN B N   1 
ATOM   4595 C CA  . ASN B 1 305 ? -6.113  -9.838  6.640   1.00  41.05 ? 305  ASN B CA  1 
ATOM   4596 C C   . ASN B 1 305 ? -4.719  -10.210 6.177   1.00  41.32 ? 305  ASN B C   1 
ATOM   4597 O O   . ASN B 1 305 ? -3.748  -9.930  6.878   1.00  41.48 ? 305  ASN B O   1 
ATOM   4598 C CB  . ASN B 1 305 ? -6.567  -10.962 7.572   1.00  41.09 ? 305  ASN B CB  1 
ATOM   4599 C CG  . ASN B 1 305 ? -7.786  -10.601 8.379   1.00  41.01 ? 305  ASN B CG  1 
ATOM   4600 O OD1 . ASN B 1 305 ? -7.908  -9.480  8.889   1.00  41.12 ? 305  ASN B OD1 1 
ATOM   4601 N ND2 . ASN B 1 305 ? -8.718  -11.565 8.492   1.00  40.36 ? 305  ASN B ND2 1 
ATOM   4602 N N   . GLY B 1 306 ? -4.626  -10.873 5.028   1.00  41.55 ? 306  GLY B N   1 
ATOM   4603 C CA  . GLY B 1 306 ? -3.366  -11.461 4.595   1.00  41.95 ? 306  GLY B CA  1 
ATOM   4604 C C   . GLY B 1 306 ? -3.236  -12.918 4.995   1.00  42.00 ? 306  GLY B C   1 
ATOM   4605 O O   . GLY B 1 306 ? -2.131  -13.471 5.015   1.00  41.96 ? 306  GLY B O   1 
ATOM   4606 N N   . GLU B 1 307 ? -4.370  -13.539 5.315   1.00  42.26 ? 307  GLU B N   1 
ATOM   4607 C CA  . GLU B 1 307 ? -4.407  -14.961 5.651   1.00  42.50 ? 307  GLU B CA  1 
ATOM   4608 C C   . GLU B 1 307 ? -4.559  -15.789 4.389   1.00  42.62 ? 307  GLU B C   1 
ATOM   4609 O O   . GLU B 1 307 ? -5.106  -15.316 3.374   1.00  42.51 ? 307  GLU B O   1 
ATOM   4610 C CB  . GLU B 1 307 ? -5.566  -15.278 6.593   1.00  42.24 ? 307  GLU B CB  1 
ATOM   4611 C CG  . GLU B 1 307 ? -5.388  -14.737 7.990   1.00  44.52 ? 307  GLU B CG  1 
ATOM   4612 C CD  . GLU B 1 307 ? -6.679  -14.742 8.818   1.00  47.20 ? 307  GLU B CD  1 
ATOM   4613 O OE1 . GLU B 1 307 ? -6.946  -13.708 9.466   1.00  48.97 ? 307  GLU B OE1 1 
ATOM   4614 O OE2 . GLU B 1 307 ? -7.425  -15.757 8.834   1.00  46.86 ? 307  GLU B OE2 1 
ATOM   4615 N N   . SER B 1 308 ? -4.087  -17.030 4.478   1.00  42.66 ? 308  SER B N   1 
ATOM   4616 C CA  . SER B 1 308 ? -4.239  -18.027 3.428   1.00  42.85 ? 308  SER B CA  1 
ATOM   4617 C C   . SER B 1 308 ? -5.714  -18.273 3.062   1.00  43.16 ? 308  SER B C   1 
ATOM   4618 O O   . SER B 1 308 ? -6.524  -18.678 3.921   1.00  42.92 ? 308  SER B O   1 
ATOM   4619 C CB  . SER B 1 308 ? -3.534  -19.331 3.852   1.00  42.79 ? 308  SER B CB  1 
ATOM   4620 O OG  . SER B 1 308 ? -3.745  -20.397 2.931   1.00  42.78 ? 308  SER B OG  1 
ATOM   4621 N N   . VAL B 1 309 ? -6.043  -18.007 1.791   1.00  43.37 ? 309  VAL B N   1 
ATOM   4622 C CA  . VAL B 1 309 ? -7.341  -18.377 1.196   1.00  43.80 ? 309  VAL B CA  1 
ATOM   4623 C C   . VAL B 1 309 ? -7.367  -19.858 0.776   1.00  43.91 ? 309  VAL B C   1 
ATOM   4624 O O   . VAL B 1 309 ? -8.408  -20.508 0.862   1.00  44.27 ? 309  VAL B O   1 
ATOM   4625 C CB  . VAL B 1 309 ? -7.691  -17.487 -0.031  1.00  43.79 ? 309  VAL B CB  1 
ATOM   4626 C CG1 . VAL B 1 309 ? -8.932  -18.003 -0.754  1.00  43.57 ? 309  VAL B CG1 1 
ATOM   4627 C CG2 . VAL B 1 309 ? -7.888  -16.044 0.386   1.00  44.21 ? 309  VAL B CG2 1 
ATOM   4628 N N   . SER B 1 310 ? -6.221  -20.377 0.332   1.00  43.91 ? 310  SER B N   1 
ATOM   4629 C CA  . SER B 1 310 ? -6.072  -21.768 -0.136  1.00  44.22 ? 310  SER B CA  1 
ATOM   4630 C C   . SER B 1 310 ? -6.691  -22.810 0.810   1.00  44.22 ? 310  SER B C   1 
ATOM   4631 O O   . SER B 1 310 ? -7.100  -23.898 0.388   1.00  44.09 ? 310  SER B O   1 
ATOM   4632 C CB  . SER B 1 310 ? -4.585  -22.087 -0.359  1.00  44.26 ? 310  SER B CB  1 
ATOM   4633 O OG  . SER B 1 310 ? -3.956  -21.094 -1.169  1.00  44.64 ? 310  SER B OG  1 
ATOM   4634 N N   . TYR B 1 311 ? -6.750  -22.451 2.089   0.50  44.13 ? 311  TYR B N   1 
ATOM   4635 C CA  . TYR B 1 311 ? -7.431  -23.222 3.127   0.50  44.10 ? 311  TYR B CA  1 
ATOM   4636 C C   . TYR B 1 311 ? -8.864  -23.636 2.757   0.50  44.09 ? 311  TYR B C   1 
ATOM   4637 O O   . TYR B 1 311 ? -9.373  -24.641 3.250   0.50  44.08 ? 311  TYR B O   1 
ATOM   4638 C CB  . TYR B 1 311 ? -7.465  -22.385 4.405   0.50  44.16 ? 311  TYR B CB  1 
ATOM   4639 C CG  . TYR B 1 311 ? -8.309  -22.970 5.505   0.50  44.10 ? 311  TYR B CG  1 
ATOM   4640 C CD1 . TYR B 1 311 ? -7.788  -23.149 6.778   0.50  44.81 ? 311  TYR B CD1 1 
ATOM   4641 C CD2 . TYR B 1 311 ? -9.623  -23.345 5.276   0.50  44.01 ? 311  TYR B CD2 1 
ATOM   4642 C CE1 . TYR B 1 311 ? -8.551  -23.690 7.797   0.50  44.62 ? 311  TYR B CE1 1 
ATOM   4643 C CE2 . TYR B 1 311 ? -10.392 -23.884 6.284   0.50  44.46 ? 311  TYR B CE2 1 
ATOM   4644 C CZ  . TYR B 1 311 ? -9.848  -24.055 7.543   0.50  44.59 ? 311  TYR B CZ  1 
ATOM   4645 O OH  . TYR B 1 311 ? -10.602 -24.589 8.556   0.50  45.23 ? 311  TYR B OH  1 
ATOM   4646 N N   . LEU B 1 312 ? -9.497  -22.850 1.891   1.00  44.12 ? 312  LEU B N   1 
ATOM   4647 C CA  . LEU B 1 312 ? -10.901 -23.017 1.524   1.00  44.36 ? 312  LEU B CA  1 
ATOM   4648 C C   . LEU B 1 312 ? -11.075 -23.856 0.270   1.00  45.23 ? 312  LEU B C   1 
ATOM   4649 O O   . LEU B 1 312 ? -12.212 -24.105 -0.157  1.00  45.38 ? 312  LEU B O   1 
ATOM   4650 C CB  . LEU B 1 312 ? -11.557 -21.648 1.277   1.00  44.07 ? 312  LEU B CB  1 
ATOM   4651 C CG  . LEU B 1 312 ? -11.558 -20.561 2.352   1.00  41.76 ? 312  LEU B CG  1 
ATOM   4652 C CD1 . LEU B 1 312 ? -11.938 -19.239 1.754   1.00  40.14 ? 312  LEU B CD1 1 
ATOM   4653 C CD2 . LEU B 1 312 ? -12.488 -20.934 3.458   1.00  40.11 ? 312  LEU B CD2 1 
ATOM   4654 N N   . PHE B 1 313 ? -9.959  -24.272 -0.328  1.00  46.12 ? 313  PHE B N   1 
ATOM   4655 C CA  . PHE B 1 313 ? -9.995  -25.045 -1.574  1.00  46.78 ? 313  PHE B CA  1 
ATOM   4656 C C   . PHE B 1 313 ? -10.316 -26.511 -1.315  1.00  46.96 ? 313  PHE B C   1 
ATOM   4657 O O   . PHE B 1 313 ? -10.622 -27.255 -2.252  1.00  47.32 ? 313  PHE B O   1 
ATOM   4658 C CB  . PHE B 1 313 ? -8.670  -24.943 -2.350  1.00  47.06 ? 313  PHE B CB  1 
ATOM   4659 C CG  . PHE B 1 313 ? -8.413  -23.587 -2.974  1.00  48.04 ? 313  PHE B CG  1 
ATOM   4660 C CD1 . PHE B 1 313 ? -9.454  -22.679 -3.190  1.00  48.57 ? 313  PHE B CD1 1 
ATOM   4661 C CD2 . PHE B 1 313 ? -7.124  -23.238 -3.375  1.00  49.13 ? 313  PHE B CD2 1 
ATOM   4662 C CE1 . PHE B 1 313 ? -9.212  -21.430 -3.776  1.00  49.47 ? 313  PHE B CE1 1 
ATOM   4663 C CE2 . PHE B 1 313 ? -6.863  -21.990 -3.958  1.00  49.95 ? 313  PHE B CE2 1 
ATOM   4664 C CZ  . PHE B 1 313 ? -7.911  -21.082 -4.161  1.00  49.68 ? 313  PHE B CZ  1 
ATOM   4665 N N   . SER B 1 314 ? -10.247 -26.914 -0.046  0.50  46.99 ? 314  SER B N   1 
ATOM   4666 C CA  . SER B 1 314 ? -10.388 -28.313 0.340   0.50  47.16 ? 314  SER B CA  1 
ATOM   4667 C C   . SER B 1 314 ? -11.095 -28.450 1.680   0.50  47.42 ? 314  SER B C   1 
ATOM   4668 O O   . SER B 1 314 ? -11.297 -29.563 2.171   0.50  47.42 ? 314  SER B O   1 
ATOM   4669 C CB  . SER B 1 314 ? -9.008  -28.974 0.436   0.50  47.18 ? 314  SER B CB  1 
ATOM   4670 O OG  . SER B 1 314 ? -8.275  -28.477 1.551   0.50  46.97 ? 314  SER B OG  1 
ATOM   4671 N N   . HIS B 1 315 ? -11.462 -27.321 2.278   0.50  47.78 ? 315  HIS B N   1 
ATOM   4672 C CA  . HIS B 1 315 ? -11.963 -27.324 3.651   0.50  48.27 ? 315  HIS B CA  1 
ATOM   4673 C C   . HIS B 1 315 ? -13.079 -26.312 3.888   0.50  48.56 ? 315  HIS B C   1 
ATOM   4674 O O   . HIS B 1 315 ? -12.818 -25.115 4.012   0.50  48.51 ? 315  HIS B O   1 
ATOM   4675 C CB  . HIS B 1 315 ? -10.807 -27.074 4.623   0.50  48.33 ? 315  HIS B CB  1 
ATOM   4676 C CG  . HIS B 1 315 ? -11.238 -26.909 6.046   0.50  49.03 ? 315  HIS B CG  1 
ATOM   4677 N ND1 . HIS B 1 315 ? -12.341 -27.552 6.567   0.50  49.63 ? 315  HIS B ND1 1 
ATOM   4678 C CD2 . HIS B 1 315 ? -10.703 -26.194 7.065   0.50  49.66 ? 315  HIS B CD2 1 
ATOM   4679 C CE1 . HIS B 1 315 ? -12.475 -27.229 7.842   0.50  49.93 ? 315  HIS B CE1 1 
ATOM   4680 N NE2 . HIS B 1 315 ? -11.493 -26.407 8.170   0.50  49.78 ? 315  HIS B NE2 1 
ATOM   4681 N N   . VAL B 1 316 ? -14.312 -26.811 3.970   1.00  49.24 ? 316  VAL B N   1 
ATOM   4682 C CA  . VAL B 1 316 ? -15.516 -25.975 4.096   1.00  49.75 ? 316  VAL B CA  1 
ATOM   4683 C C   . VAL B 1 316 ? -15.555 -25.298 5.470   1.00  50.12 ? 316  VAL B C   1 
ATOM   4684 O O   . VAL B 1 316 ? -15.733 -25.977 6.486   1.00  50.69 ? 316  VAL B O   1 
ATOM   4685 C CB  . VAL B 1 316 ? -16.837 -26.788 3.908   1.00  49.91 ? 316  VAL B CB  1 
ATOM   4686 C CG1 . VAL B 1 316 ? -17.869 -25.966 3.129   1.00  49.44 ? 316  VAL B CG1 1 
ATOM   4687 C CG2 . VAL B 1 316 ? -16.588 -28.156 3.223   1.00  50.43 ? 316  VAL B CG2 1 
ATOM   4688 N N   . PRO B 1 317 ? -15.396 -23.958 5.509   0.80  50.31 ? 317  PRO B N   1 
ATOM   4689 C CA  . PRO B 1 317 ? -15.341 -23.235 6.792   0.80  50.37 ? 317  PRO B CA  1 
ATOM   4690 C C   . PRO B 1 317 ? -16.593 -23.459 7.643   0.80  50.58 ? 317  PRO B C   1 
ATOM   4691 O O   . PRO B 1 317 ? -16.666 -24.432 8.403   0.80  50.64 ? 317  PRO B O   1 
ATOM   4692 C CB  . PRO B 1 317 ? -15.240 -21.761 6.374   0.80  50.30 ? 317  PRO B CB  1 
ATOM   4693 C CG  . PRO B 1 317 ? -15.757 -21.726 4.956   0.80  50.52 ? 317  PRO B CG  1 
ATOM   4694 C CD  . PRO B 1 317 ? -15.365 -23.041 4.353   0.80  50.25 ? 317  PRO B CD  1 
HETATM 4695 S S   . SO4 C 2 .   ? -9.181  16.278  -41.884 1.00  29.21 ? 1001 SO4 A S   1 
HETATM 4696 O O1  . SO4 C 2 .   ? -8.587  16.556  -40.576 1.00  31.42 ? 1001 SO4 A O1  1 
HETATM 4697 O O2  . SO4 C 2 .   ? -10.447 15.582  -41.698 1.00  29.07 ? 1001 SO4 A O2  1 
HETATM 4698 O O3  . SO4 C 2 .   ? -9.366  17.537  -42.581 1.00  27.02 ? 1001 SO4 A O3  1 
HETATM 4699 O O4  . SO4 C 2 .   ? -8.335  15.402  -42.690 1.00  29.37 ? 1001 SO4 A O4  1 
HETATM 4700 S S   . SO4 D 2 .   ? -35.199 14.165  -19.466 0.68  87.73 ? 1002 SO4 A S   1 
HETATM 4701 O O1  . SO4 D 2 .   ? -34.566 14.713  -20.668 0.68  87.83 ? 1002 SO4 A O1  1 
HETATM 4702 O O2  . SO4 D 2 .   ? -35.848 15.214  -18.685 0.68  87.75 ? 1002 SO4 A O2  1 
HETATM 4703 O O3  . SO4 D 2 .   ? -36.207 13.244  -19.908 0.68  87.68 ? 1002 SO4 A O3  1 
HETATM 4704 O O4  . SO4 D 2 .   ? -34.233 13.446  -18.639 0.68  87.03 ? 1002 SO4 A O4  1 
HETATM 4705 S S   . SO4 E 2 .   ? -2.944  -18.410 -0.036  1.00  29.40 ? 401  SO4 B S   1 
HETATM 4706 O O1  . SO4 E 2 .   ? -2.577  -17.155 0.627   1.00  27.09 ? 401  SO4 B O1  1 
HETATM 4707 O O2  . SO4 E 2 .   ? -2.684  -19.508 0.890   1.00  30.46 ? 401  SO4 B O2  1 
HETATM 4708 O O3  . SO4 E 2 .   ? -4.343  -18.366 -0.449  1.00  30.93 ? 401  SO4 B O3  1 
HETATM 4709 O O4  . SO4 E 2 .   ? -2.146  -18.728 -1.221  1.00  30.77 ? 401  SO4 B O4  1 
HETATM 4710 S S   . SO4 F 2 .   ? -27.595 -26.275 -21.421 1.00  90.67 ? 402  SO4 B S   1 
HETATM 4711 O O1  . SO4 F 2 .   ? -28.951 -25.993 -21.882 1.00  90.28 ? 402  SO4 B O1  1 
HETATM 4712 O O2  . SO4 F 2 .   ? -27.613 -26.825 -20.063 1.00  90.25 ? 402  SO4 B O2  1 
HETATM 4713 O O3  . SO4 F 2 .   ? -26.971 -27.232 -22.333 1.00  90.76 ? 402  SO4 B O3  1 
HETATM 4714 O O4  . SO4 F 2 .   ? -26.824 -25.033 -21.445 1.00  91.11 ? 402  SO4 B O4  1 
HETATM 4715 S S   . SO4 G 2 .   ? -7.339  -23.215 -10.799 0.53  55.24 ? 403  SO4 B S   1 
HETATM 4716 O O1  . SO4 G 2 .   ? -7.981  -21.931 -10.577 0.53  54.79 ? 403  SO4 B O1  1 
HETATM 4717 O O2  . SO4 G 2 .   ? -6.494  -23.585 -9.661  0.53  54.66 ? 403  SO4 B O2  1 
HETATM 4718 O O3  . SO4 G 2 .   ? -8.387  -24.214 -11.040 0.53  55.25 ? 403  SO4 B O3  1 
HETATM 4719 O O4  . SO4 G 2 .   ? -6.488  -23.102 -11.973 0.53  56.01 ? 403  SO4 B O4  1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   PRO 2   2   ?   ?   ?   A . n 
A 1 3   ASN 3   3   3   ASN ASN A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   ILE 6   6   6   ILE ILE A . n 
A 1 7   PHE 7   7   7   PHE PHE A . n 
A 1 8   SER 8   8   8   SER SER A . n 
A 1 9   GLY 9   9   9   GLY GLY A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  SER 11  11  11  SER SER A . n 
A 1 12  HIS 12  12  12  HIS HIS A . n 
A 1 13  GLN 13  13  13  GLN GLN A . n 
A 1 14  ASP 14  14  14  ASP ASP A . n 
A 1 15  LEU 15  15  15  LEU LEU A . n 
A 1 16  SER 16  16  16  SER SER A . n 
A 1 17  GLN 17  17  17  GLN GLN A . n 
A 1 18  LYS 18  18  18  LYS LYS A . n 
A 1 19  ILE 19  19  19  ILE ILE A . n 
A 1 20  ALA 20  20  20  ALA ALA A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  ARG 22  22  22  ARG ARG A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  GLY 24  24  24  GLY GLY A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  GLU 26  26  26  GLU GLU A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  GLY 28  28  28  GLY GLY A . n 
A 1 29  LYS 29  29  29  LYS LYS A . n 
A 1 30  VAL 30  30  30  VAL VAL A . n 
A 1 31  VAL 31  31  31  VAL VAL A . n 
A 1 32  THR 32  32  32  THR THR A . n 
A 1 33  LYS 33  33  33  LYS LYS A . n 
A 1 34  LYS 34  34  34  LYS LYS A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  SER 36  36  36  SER SER A . n 
A 1 37  ASN 37  37  37  ASN ASN A . n 
A 1 38  GLN 38  38  38  GLN GLN A . n 
A 1 39  GLU 39  39  39  GLU GLU A . n 
A 1 40  THR 40  40  40  THR THR A . n 
A 1 41  CYS 41  41  41  CYS CYS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  THR 43  43  43  THR THR A . n 
A 1 44  ILE 44  44  44  ILE ILE A . n 
A 1 45  GLY 45  45  45  GLY GLY A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  SER 47  47  47  SER SER A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  GLU 51  51  51  GLU GLU A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  VAL 53  53  53  VAL VAL A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  ILE 55  55  55  ILE ILE A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  SER 58  58  58  SER SER A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  CYS 60  60  60  CYS CYS A . n 
A 1 61  GLY 61  61  61  GLY GLY A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  ILE 63  63  63  ILE ILE A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  ASP 65  65  65  ASP ASP A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  MET 73  73  73  MET MET A . n 
A 1 74  ILE 74  74  74  ILE ILE A . n 
A 1 75  ASN 75  75  75  ASN ASN A . n 
A 1 76  ALA 76  76  76  ALA ALA A . n 
A 1 77  CYS 77  77  77  CYS CYS A . n 
A 1 78  LYS 78  78  78  LYS LYS A . n 
A 1 79  ILE 79  79  79  ILE ILE A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  SER 83  83  83  SER SER A . n 
A 1 84  ARG 84  84  84  ARG ARG A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  THR 86  86  86  THR THR A . n 
A 1 87  ALA 87  87  87  ALA ALA A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  CYS 91  91  91  CYS CYS A . n 
A 1 92  PHE 92  92  92  PHE PHE A . n 
A 1 93  PRO 93  93  93  PRO PRO A . n 
A 1 94  TYR 94  94  94  TYR TYR A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  GLN 97  97  97  GLN GLN A . n 
A 1 98  ASP 98  98  98  ASP ASP A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 ASP 101 101 101 ASP ASP A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 SER 103 103 103 SER SER A . n 
A 1 104 ARG 104 104 104 ARG ARG A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 PRO 106 106 106 PRO PRO A . n 
A 1 107 ILE 107 107 107 ILE ILE A . n 
A 1 108 SER 108 108 108 SER SER A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 LYS 110 110 110 LYS LYS A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 ALA 113 113 113 ALA ALA A . n 
A 1 114 ASN 114 114 114 ASN ASN A . n 
A 1 115 MET 115 115 115 MET MET A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 ALA 119 119 119 ALA ALA A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 ALA 121 121 121 ALA ALA A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 HIS 123 123 123 HIS HIS A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 MET 127 127 127 MET MET A . n 
A 1 128 ASP 128 128 128 ASP ASP A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 HIS 130 130 130 HIS HIS A . n 
A 1 131 ALA 131 131 131 ALA ALA A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 GLN 133 133 133 GLN GLN A . n 
A 1 134 ILE 134 134 134 ILE ILE A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 GLY 136 136 136 GLY GLY A . n 
A 1 137 PHE 137 137 137 PHE PHE A . n 
A 1 138 PHE 138 138 138 PHE PHE A . n 
A 1 139 ASP 139 139 139 ASP ASP A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 PRO 141 141 141 PRO PRO A . n 
A 1 142 VAL 142 142 142 VAL VAL A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 ASN 144 144 144 ASN ASN A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 TYR 146 146 146 TYR TYR A . n 
A 1 147 ALA 147 147 147 ALA ALA A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 PRO 149 149 149 PRO PRO A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 LYS 153 153 153 LYS LYS A . n 
A 1 154 TRP 154 154 154 TRP TRP A . n 
A 1 155 ILE 155 155 155 ILE ILE A . n 
A 1 156 ARG 156 156 156 ARG ARG A . n 
A 1 157 GLU 157 157 157 GLU GLU A . n 
A 1 158 ASN 158 158 158 ASN ASN A . n 
A 1 159 ILE 159 159 159 ILE ILE A . n 
A 1 160 SER 160 160 160 SER SER A . n 
A 1 161 GLU 161 161 161 GLU GLU A . n 
A 1 162 TRP 162 162 162 TRP TRP A . n 
A 1 163 ARG 163 163 163 ARG ARG A . n 
A 1 164 ASN 164 164 164 ASN ASN A . n 
A 1 165 CYS 165 165 165 CYS CYS A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 ILE 167 167 167 ILE ILE A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 SER 169 169 169 SER SER A . n 
A 1 170 PRO 170 170 170 PRO PRO A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 LYS 176 176 176 LYS LYS A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 THR 179 179 179 THR THR A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 ILE 181 181 181 ILE ILE A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 ARG 184 184 184 ARG ARG A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 ASN 186 186 186 ASN ASN A . n 
A 1 187 VAL 187 187 187 VAL VAL A . n 
A 1 188 ASP 188 188 188 ASP ASP A . n 
A 1 189 PHE 189 189 189 PHE PHE A . n 
A 1 190 ALA 190 190 190 ALA ALA A . n 
A 1 191 LEU 191 191 191 LEU LEU A . n 
A 1 192 ILE 192 192 192 ILE ILE A . n 
A 1 193 HIS 193 193 193 HIS HIS A . n 
A 1 194 LYS 194 194 194 LYS LYS A . n 
A 1 195 GLU 195 195 195 GLU GLU A . n 
A 1 196 ARG 196 196 ?   ?   ?   A . n 
A 1 197 LYS 197 197 ?   ?   ?   A . n 
A 1 198 LYS 198 198 ?   ?   ?   A . n 
A 1 199 ALA 199 199 ?   ?   ?   A . n 
A 1 200 ASN 200 200 ?   ?   ?   A . n 
A 1 201 GLU 201 201 ?   ?   ?   A . n 
A 1 202 VAL 202 202 ?   ?   ?   A . n 
A 1 203 ASP 203 203 203 ASP ASP A . n 
A 1 204 ARG 204 204 204 ARG ARG A . n 
A 1 205 MET 205 205 205 MET MET A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 VAL 208 208 208 VAL VAL A . n 
A 1 209 GLY 209 209 209 GLY GLY A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 VAL 211 211 211 VAL VAL A . n 
A 1 212 LYS 212 212 212 LYS LYS A . n 
A 1 213 ASP 213 213 213 ASP ASP A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 ALA 216 216 216 ALA ALA A . n 
A 1 217 ILE 217 217 217 ILE ILE A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 VAL 219 219 219 VAL VAL A . n 
A 1 220 ASP 220 220 220 ASP ASP A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 MET 222 222 222 MET MET A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 ASP 224 224 224 ASP ASP A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 CYS 226 226 226 CYS CYS A . n 
A 1 227 GLY 227 227 227 GLY GLY A . n 
A 1 228 THR 228 228 228 THR THR A . n 
A 1 229 ILE 229 229 229 ILE ILE A . n 
A 1 230 CYS 230 230 230 CYS CYS A . n 
A 1 231 HIS 231 231 231 HIS HIS A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 ALA 233 233 233 ALA ALA A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 LYS 235 235 235 LYS LYS A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 SER 238 238 238 SER SER A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 GLY 240 240 240 GLY GLY A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 THR 242 242 242 THR THR A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 TYR 245 245 245 TYR TYR A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 THR 249 249 249 THR THR A . n 
A 1 250 HIS 250 250 250 HIS HIS A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 ILE 252 252 252 ILE ILE A . n 
A 1 253 PHE 253 253 253 PHE PHE A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 GLY 255 255 255 GLY GLY A . n 
A 1 256 PRO 256 256 256 PRO PRO A . n 
A 1 257 ALA 257 257 257 ALA ALA A . n 
A 1 258 ILE 258 258 258 ILE ILE A . n 
A 1 259 SER 259 259 259 SER SER A . n 
A 1 260 ARG 260 260 260 ARG ARG A . n 
A 1 261 ILE 261 261 261 ILE ILE A . n 
A 1 262 ASN 262 262 262 ASN ASN A . n 
A 1 263 ASN 263 263 263 ASN ASN A . n 
A 1 264 ALA 264 264 264 ALA ALA A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 PHE 266 266 266 PHE PHE A . n 
A 1 267 GLU 267 267 267 GLU GLU A . n 
A 1 268 ALA 268 268 268 ALA ALA A . n 
A 1 269 VAL 269 269 269 VAL VAL A . n 
A 1 270 VAL 270 270 270 VAL VAL A . n 
A 1 271 VAL 271 271 271 VAL VAL A . n 
A 1 272 THR 272 272 272 THR THR A . n 
A 1 273 ASN 273 273 273 ASN ASN A . n 
A 1 274 THR 274 274 274 THR THR A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 PRO 276 276 276 PRO PRO A . n 
A 1 277 GLN 277 277 277 GLN GLN A . n 
A 1 278 GLU 278 278 278 GLU GLU A . n 
A 1 279 ASP 279 279 279 ASP ASP A . n 
A 1 280 LYS 280 280 280 LYS LYS A . n 
A 1 281 MET 281 281 281 MET MET A . n 
A 1 282 LYS 282 282 282 LYS LYS A . n 
A 1 283 HIS 283 283 283 HIS HIS A . n 
A 1 284 CYS 284 284 284 CYS CYS A . n 
A 1 285 SER 285 285 285 SER SER A . n 
A 1 286 LYS 286 286 286 LYS LYS A . n 
A 1 287 ILE 287 287 287 ILE ILE A . n 
A 1 288 GLN 288 288 288 GLN GLN A . n 
A 1 289 VAL 289 289 289 VAL VAL A . n 
A 1 290 ILE 290 290 290 ILE ILE A . n 
A 1 291 ASP 291 291 291 ASP ASP A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 SER 293 293 293 SER SER A . n 
A 1 294 MET 294 294 294 MET MET A . n 
A 1 295 ILE 295 295 295 ILE ILE A . n 
A 1 296 LEU 296 296 296 LEU LEU A . n 
A 1 297 ALA 297 297 297 ALA ALA A . n 
A 1 298 GLU 298 298 298 GLU GLU A . n 
A 1 299 ALA 299 299 299 ALA ALA A . n 
A 1 300 ILE 300 300 300 ILE ILE A . n 
A 1 301 ARG 301 301 301 ARG ARG A . n 
A 1 302 ARG 302 302 302 ARG ARG A . n 
A 1 303 THR 303 303 303 THR THR A . n 
A 1 304 HIS 304 304 304 HIS HIS A . n 
A 1 305 ASN 305 305 305 ASN ASN A . n 
A 1 306 GLY 306 306 306 GLY GLY A . n 
A 1 307 GLU 307 307 307 GLU GLU A . n 
A 1 308 SER 308 308 308 SER SER A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 SER 310 310 310 SER SER A . n 
A 1 311 TYR 311 311 311 TYR TYR A . n 
A 1 312 LEU 312 312 312 LEU LEU A . n 
A 1 313 PHE 313 313 313 PHE PHE A . n 
A 1 314 SER 314 314 ?   ?   ?   A . n 
A 1 315 HIS 315 315 ?   ?   ?   A . n 
A 1 316 VAL 316 316 ?   ?   ?   A . n 
A 1 317 PRO 317 317 ?   ?   ?   A . n 
A 1 318 LEU 318 318 ?   ?   ?   A . n 
A 1 319 LEU 319 319 ?   ?   ?   A . n 
A 1 320 GLU 320 320 ?   ?   ?   A . n 
A 1 321 HIS 321 321 ?   ?   ?   A . n 
A 1 322 HIS 322 322 ?   ?   ?   A . n 
A 1 323 HIS 323 323 ?   ?   ?   A . n 
A 1 324 HIS 324 324 ?   ?   ?   A . n 
A 1 325 HIS 325 325 ?   ?   ?   A . n 
A 1 326 HIS 326 326 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   PRO 2   2   ?   ?   ?   B . n 
B 1 3   ASN 3   3   3   ASN ASN B . n 
B 1 4   ILE 4   4   4   ILE ILE B . n 
B 1 5   LYS 5   5   5   LYS LYS B . n 
B 1 6   ILE 6   6   6   ILE ILE B . n 
B 1 7   PHE 7   7   7   PHE PHE B . n 
B 1 8   SER 8   8   8   SER SER B . n 
B 1 9   GLY 9   9   9   GLY GLY B . n 
B 1 10  SER 10  10  10  SER SER B . n 
B 1 11  SER 11  11  11  SER SER B . n 
B 1 12  HIS 12  12  12  HIS HIS B . n 
B 1 13  GLN 13  13  13  GLN GLN B . n 
B 1 14  ASP 14  14  14  ASP ASP B . n 
B 1 15  LEU 15  15  15  LEU LEU B . n 
B 1 16  SER 16  16  16  SER SER B . n 
B 1 17  GLN 17  17  17  GLN GLN B . n 
B 1 18  LYS 18  18  18  LYS LYS B . n 
B 1 19  ILE 19  19  19  ILE ILE B . n 
B 1 20  ALA 20  20  20  ALA ALA B . n 
B 1 21  ASP 21  21  21  ASP ASP B . n 
B 1 22  ARG 22  22  22  ARG ARG B . n 
B 1 23  LEU 23  23  23  LEU LEU B . n 
B 1 24  GLY 24  24  24  GLY GLY B . n 
B 1 25  LEU 25  25  25  LEU LEU B . n 
B 1 26  GLU 26  26  26  GLU GLU B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  GLY 28  28  28  GLY GLY B . n 
B 1 29  LYS 29  29  29  LYS LYS B . n 
B 1 30  VAL 30  30  30  VAL VAL B . n 
B 1 31  VAL 31  31  31  VAL VAL B . n 
B 1 32  THR 32  32  32  THR THR B . n 
B 1 33  LYS 33  33  33  LYS LYS B . n 
B 1 34  LYS 34  34  34  LYS LYS B . n 
B 1 35  PHE 35  35  35  PHE PHE B . n 
B 1 36  SER 36  36  36  SER SER B . n 
B 1 37  ASN 37  37  37  ASN ASN B . n 
B 1 38  GLN 38  38  38  GLN GLN B . n 
B 1 39  GLU 39  39  39  GLU GLU B . n 
B 1 40  THR 40  40  40  THR THR B . n 
B 1 41  CYS 41  41  41  CYS CYS B . n 
B 1 42  VAL 42  42  42  VAL VAL B . n 
B 1 43  THR 43  43  43  THR THR B . n 
B 1 44  ILE 44  44  44  ILE ILE B . n 
B 1 45  GLY 45  45  45  GLY GLY B . n 
B 1 46  GLU 46  46  46  GLU GLU B . n 
B 1 47  SER 47  47  47  SER SER B . n 
B 1 48  VAL 48  48  48  VAL VAL B . n 
B 1 49  ARG 49  49  49  ARG ARG B . n 
B 1 50  GLY 50  50  50  GLY GLY B . n 
B 1 51  GLU 51  51  51  GLU GLU B . n 
B 1 52  ASP 52  52  52  ASP ASP B . n 
B 1 53  VAL 53  53  53  VAL VAL B . n 
B 1 54  TYR 54  54  54  TYR TYR B . n 
B 1 55  ILE 55  55  55  ILE ILE B . n 
B 1 56  VAL 56  56  56  VAL VAL B . n 
B 1 57  GLN 57  57  57  GLN GLN B . n 
B 1 58  SER 58  58  58  SER SER B . n 
B 1 59  GLY 59  59  59  GLY GLY B . n 
B 1 60  CYS 60  60  60  CYS CYS B . n 
B 1 61  GLY 61  61  61  GLY GLY B . n 
B 1 62  GLU 62  62  62  GLU GLU B . n 
B 1 63  ILE 63  63  63  ILE ILE B . n 
B 1 64  ASN 64  64  64  ASN ASN B . n 
B 1 65  ASP 65  65  65  ASP ASP B . n 
B 1 66  ASN 66  66  66  ASN ASN B . n 
B 1 67  LEU 67  67  67  LEU LEU B . n 
B 1 68  MET 68  68  68  MET MET B . n 
B 1 69  GLU 69  69  69  GLU GLU B . n 
B 1 70  LEU 70  70  70  LEU LEU B . n 
B 1 71  LEU 71  71  71  LEU LEU B . n 
B 1 72  ILE 72  72  72  ILE ILE B . n 
B 1 73  MET 73  73  73  MET MET B . n 
B 1 74  ILE 74  74  74  ILE ILE B . n 
B 1 75  ASN 75  75  75  ASN ASN B . n 
B 1 76  ALA 76  76  76  ALA ALA B . n 
B 1 77  CYS 77  77  77  CYS CYS B . n 
B 1 78  LYS 78  78  78  LYS LYS B . n 
B 1 79  ILE 79  79  79  ILE ILE B . n 
B 1 80  ALA 80  80  80  ALA ALA B . n 
B 1 81  SER 81  81  81  SER SER B . n 
B 1 82  ALA 82  82  82  ALA ALA B . n 
B 1 83  SER 83  83  83  SER SER B . n 
B 1 84  ARG 84  84  84  ARG ARG B . n 
B 1 85  VAL 85  85  85  VAL VAL B . n 
B 1 86  THR 86  86  86  THR THR B . n 
B 1 87  ALA 87  87  87  ALA ALA B . n 
B 1 88  VAL 88  88  88  VAL VAL B . n 
B 1 89  ILE 89  89  89  ILE ILE B . n 
B 1 90  PRO 90  90  90  PRO PRO B . n 
B 1 91  CYS 91  91  91  CYS CYS B . n 
B 1 92  PHE 92  92  92  PHE PHE B . n 
B 1 93  PRO 93  93  93  PRO PRO B . n 
B 1 94  TYR 94  94  94  TYR TYR B . n 
B 1 95  ALA 95  95  95  ALA ALA B . n 
B 1 96  ARG 96  96  96  ARG ARG B . n 
B 1 97  GLN 97  97  97  GLN GLN B . n 
B 1 98  ASP 98  98  98  ASP ASP B . n 
B 1 99  LYS 99  99  99  LYS LYS B . n 
B 1 100 LYS 100 100 100 LYS LYS B . n 
B 1 101 ASP 101 101 101 ASP ASP B . n 
B 1 102 LYS 102 102 102 LYS LYS B . n 
B 1 103 SER 103 103 103 SER SER B . n 
B 1 104 ARG 104 104 104 ARG ARG B . n 
B 1 105 ALA 105 105 105 ALA ALA B . n 
B 1 106 PRO 106 106 106 PRO PRO B . n 
B 1 107 ILE 107 107 107 ILE ILE B . n 
B 1 108 SER 108 108 108 SER SER B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 LYS 110 110 110 LYS LYS B . n 
B 1 111 LEU 111 111 111 LEU LEU B . n 
B 1 112 VAL 112 112 112 VAL VAL B . n 
B 1 113 ALA 113 113 113 ALA ALA B . n 
B 1 114 ASN 114 114 114 ASN ASN B . n 
B 1 115 MET 115 115 115 MET MET B . n 
B 1 116 LEU 116 116 116 LEU LEU B . n 
B 1 117 SER 117 117 117 SER SER B . n 
B 1 118 VAL 118 118 118 VAL VAL B . n 
B 1 119 ALA 119 119 119 ALA ALA B . n 
B 1 120 GLY 120 120 120 GLY GLY B . n 
B 1 121 ALA 121 121 121 ALA ALA B . n 
B 1 122 ASP 122 122 122 ASP ASP B . n 
B 1 123 HIS 123 123 123 HIS HIS B . n 
B 1 124 ILE 124 124 124 ILE ILE B . n 
B 1 125 ILE 125 125 125 ILE ILE B . n 
B 1 126 THR 126 126 126 THR THR B . n 
B 1 127 MET 127 127 127 MET MET B . n 
B 1 128 ASP 128 128 128 ASP ASP B . n 
B 1 129 LEU 129 129 129 LEU LEU B . n 
B 1 130 HIS 130 130 130 HIS HIS B . n 
B 1 131 ALA 131 131 131 ALA ALA B . n 
B 1 132 SER 132 132 132 SER SER B . n 
B 1 133 GLN 133 133 133 GLN GLN B . n 
B 1 134 ILE 134 134 134 ILE ILE B . n 
B 1 135 GLN 135 135 135 GLN GLN B . n 
B 1 136 GLY 136 136 136 GLY GLY B . n 
B 1 137 PHE 137 137 137 PHE PHE B . n 
B 1 138 PHE 138 138 138 PHE PHE B . n 
B 1 139 ASP 139 139 139 ASP ASP B . n 
B 1 140 ILE 140 140 140 ILE ILE B . n 
B 1 141 PRO 141 141 141 PRO PRO B . n 
B 1 142 VAL 142 142 142 VAL VAL B . n 
B 1 143 ASP 143 143 143 ASP ASP B . n 
B 1 144 ASN 144 144 144 ASN ASN B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 TYR 146 146 146 TYR TYR B . n 
B 1 147 ALA 147 147 147 ALA ALA B . n 
B 1 148 GLU 148 148 148 GLU GLU B . n 
B 1 149 PRO 149 149 149 PRO PRO B . n 
B 1 150 ALA 150 150 150 ALA ALA B . n 
B 1 151 VAL 151 151 151 VAL VAL B . n 
B 1 152 LEU 152 152 152 LEU LEU B . n 
B 1 153 LYS 153 153 153 LYS LYS B . n 
B 1 154 TRP 154 154 154 TRP TRP B . n 
B 1 155 ILE 155 155 155 ILE ILE B . n 
B 1 156 ARG 156 156 156 ARG ARG B . n 
B 1 157 GLU 157 157 157 GLU GLU B . n 
B 1 158 ASN 158 158 158 ASN ASN B . n 
B 1 159 ILE 159 159 159 ILE ILE B . n 
B 1 160 SER 160 160 160 SER SER B . n 
B 1 161 GLU 161 161 161 GLU GLU B . n 
B 1 162 TRP 162 162 162 TRP TRP B . n 
B 1 163 ARG 163 163 163 ARG ARG B . n 
B 1 164 ASN 164 164 164 ASN ASN B . n 
B 1 165 CYS 165 165 165 CYS CYS B . n 
B 1 166 THR 166 166 166 THR THR B . n 
B 1 167 ILE 167 167 167 ILE ILE B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 SER 169 169 169 SER SER B . n 
B 1 170 PRO 170 170 170 PRO PRO B . n 
B 1 171 ASP 171 171 171 ASP ASP B . n 
B 1 172 ALA 172 172 172 ALA ALA B . n 
B 1 173 GLY 173 173 173 GLY GLY B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 LYS 176 176 176 LYS LYS B . n 
B 1 177 ARG 177 177 177 ARG ARG B . n 
B 1 178 VAL 178 178 178 VAL VAL B . n 
B 1 179 THR 179 179 179 THR THR B . n 
B 1 180 SER 180 180 180 SER SER B . n 
B 1 181 ILE 181 181 181 ILE ILE B . n 
B 1 182 ALA 182 182 182 ALA ALA B . n 
B 1 183 ASP 183 183 183 ASP ASP B . n 
B 1 184 ARG 184 184 184 ARG ARG B . n 
B 1 185 LEU 185 185 185 LEU LEU B . n 
B 1 186 ASN 186 186 186 ASN ASN B . n 
B 1 187 VAL 187 187 187 VAL VAL B . n 
B 1 188 ASP 188 188 188 ASP ASP B . n 
B 1 189 PHE 189 189 189 PHE PHE B . n 
B 1 190 ALA 190 190 190 ALA ALA B . n 
B 1 191 LEU 191 191 191 LEU LEU B . n 
B 1 192 ILE 192 192 192 ILE ILE B . n 
B 1 193 HIS 193 193 193 HIS HIS B . n 
B 1 194 LYS 194 194 194 LYS LYS B . n 
B 1 195 GLU 195 195 195 GLU GLU B . n 
B 1 196 ARG 196 196 196 ARG ARG B . n 
B 1 197 LYS 197 197 197 LYS LYS B . n 
B 1 198 LYS 198 198 ?   ?   ?   B . n 
B 1 199 ALA 199 199 ?   ?   ?   B . n 
B 1 200 ASN 200 200 ?   ?   ?   B . n 
B 1 201 GLU 201 201 ?   ?   ?   B . n 
B 1 202 VAL 202 202 ?   ?   ?   B . n 
B 1 203 ASP 203 203 203 ASP ASP B . n 
B 1 204 ARG 204 204 204 ARG ARG B . n 
B 1 205 MET 205 205 205 MET MET B . n 
B 1 206 VAL 206 206 206 VAL VAL B . n 
B 1 207 LEU 207 207 207 LEU LEU B . n 
B 1 208 VAL 208 208 208 VAL VAL B . n 
B 1 209 GLY 209 209 209 GLY GLY B . n 
B 1 210 ASP 210 210 210 ASP ASP B . n 
B 1 211 VAL 211 211 211 VAL VAL B . n 
B 1 212 LYS 212 212 212 LYS LYS B . n 
B 1 213 ASP 213 213 213 ASP ASP B . n 
B 1 214 ARG 214 214 214 ARG ARG B . n 
B 1 215 VAL 215 215 215 VAL VAL B . n 
B 1 216 ALA 216 216 216 ALA ALA B . n 
B 1 217 ILE 217 217 217 ILE ILE B . n 
B 1 218 LEU 218 218 218 LEU LEU B . n 
B 1 219 VAL 219 219 219 VAL VAL B . n 
B 1 220 ASP 220 220 220 ASP ASP B . n 
B 1 221 ASP 221 221 221 ASP ASP B . n 
B 1 222 MET 222 222 222 MET MET B . n 
B 1 223 ALA 223 223 223 ALA ALA B . n 
B 1 224 ASP 224 224 224 ASP ASP B . n 
B 1 225 THR 225 225 225 THR THR B . n 
B 1 226 CYS 226 226 226 CYS CYS B . n 
B 1 227 GLY 227 227 227 GLY GLY B . n 
B 1 228 THR 228 228 228 THR THR B . n 
B 1 229 ILE 229 229 229 ILE ILE B . n 
B 1 230 CYS 230 230 230 CYS CYS B . n 
B 1 231 HIS 231 231 231 HIS HIS B . n 
B 1 232 ALA 232 232 232 ALA ALA B . n 
B 1 233 ALA 233 233 233 ALA ALA B . n 
B 1 234 ASP 234 234 234 ASP ASP B . n 
B 1 235 LYS 235 235 235 LYS LYS B . n 
B 1 236 LEU 236 236 236 LEU LEU B . n 
B 1 237 LEU 237 237 237 LEU LEU B . n 
B 1 238 SER 238 238 238 SER SER B . n 
B 1 239 ALA 239 239 239 ALA ALA B . n 
B 1 240 GLY 240 240 240 GLY GLY B . n 
B 1 241 ALA 241 241 241 ALA ALA B . n 
B 1 242 THR 242 242 242 THR THR B . n 
B 1 243 ARG 243 243 243 ARG ARG B . n 
B 1 244 VAL 244 244 244 VAL VAL B . n 
B 1 245 TYR 245 245 245 TYR TYR B . n 
B 1 246 ALA 246 246 246 ALA ALA B . n 
B 1 247 ILE 247 247 247 ILE ILE B . n 
B 1 248 LEU 248 248 248 LEU LEU B . n 
B 1 249 THR 249 249 249 THR THR B . n 
B 1 250 HIS 250 250 250 HIS HIS B . n 
B 1 251 GLY 251 251 251 GLY GLY B . n 
B 1 252 ILE 252 252 252 ILE ILE B . n 
B 1 253 PHE 253 253 253 PHE PHE B . n 
B 1 254 SER 254 254 254 SER SER B . n 
B 1 255 GLY 255 255 255 GLY GLY B . n 
B 1 256 PRO 256 256 256 PRO PRO B . n 
B 1 257 ALA 257 257 257 ALA ALA B . n 
B 1 258 ILE 258 258 258 ILE ILE B . n 
B 1 259 SER 259 259 259 SER SER B . n 
B 1 260 ARG 260 260 260 ARG ARG B . n 
B 1 261 ILE 261 261 261 ILE ILE B . n 
B 1 262 ASN 262 262 262 ASN ASN B . n 
B 1 263 ASN 263 263 263 ASN ASN B . n 
B 1 264 ALA 264 264 264 ALA ALA B . n 
B 1 265 CYS 265 265 265 CYS CYS B . n 
B 1 266 PHE 266 266 266 PHE PHE B . n 
B 1 267 GLU 267 267 267 GLU GLU B . n 
B 1 268 ALA 268 268 268 ALA ALA B . n 
B 1 269 VAL 269 269 269 VAL VAL B . n 
B 1 270 VAL 270 270 270 VAL VAL B . n 
B 1 271 VAL 271 271 271 VAL VAL B . n 
B 1 272 THR 272 272 272 THR THR B . n 
B 1 273 ASN 273 273 273 ASN ASN B . n 
B 1 274 THR 274 274 274 THR THR B . n 
B 1 275 ILE 275 275 275 ILE ILE B . n 
B 1 276 PRO 276 276 276 PRO PRO B . n 
B 1 277 GLN 277 277 277 GLN GLN B . n 
B 1 278 GLU 278 278 278 GLU GLU B . n 
B 1 279 ASP 279 279 279 ASP ASP B . n 
B 1 280 LYS 280 280 280 LYS LYS B . n 
B 1 281 MET 281 281 281 MET MET B . n 
B 1 282 LYS 282 282 282 LYS LYS B . n 
B 1 283 HIS 283 283 283 HIS HIS B . n 
B 1 284 CYS 284 284 284 CYS CYS B . n 
B 1 285 SER 285 285 285 SER SER B . n 
B 1 286 LYS 286 286 286 LYS LYS B . n 
B 1 287 ILE 287 287 287 ILE ILE B . n 
B 1 288 GLN 288 288 288 GLN GLN B . n 
B 1 289 VAL 289 289 289 VAL VAL B . n 
B 1 290 ILE 290 290 290 ILE ILE B . n 
B 1 291 ASP 291 291 291 ASP ASP B . n 
B 1 292 ILE 292 292 292 ILE ILE B . n 
B 1 293 SER 293 293 293 SER SER B . n 
B 1 294 MET 294 294 294 MET MET B . n 
B 1 295 ILE 295 295 295 ILE ILE B . n 
B 1 296 LEU 296 296 296 LEU LEU B . n 
B 1 297 ALA 297 297 297 ALA ALA B . n 
B 1 298 GLU 298 298 298 GLU GLU B . n 
B 1 299 ALA 299 299 299 ALA ALA B . n 
B 1 300 ILE 300 300 300 ILE ILE B . n 
B 1 301 ARG 301 301 301 ARG ARG B . n 
B 1 302 ARG 302 302 302 ARG ARG B . n 
B 1 303 THR 303 303 303 THR THR B . n 
B 1 304 HIS 304 304 304 HIS HIS B . n 
B 1 305 ASN 305 305 305 ASN ASN B . n 
B 1 306 GLY 306 306 306 GLY GLY B . n 
B 1 307 GLU 307 307 307 GLU GLU B . n 
B 1 308 SER 308 308 308 SER SER B . n 
B 1 309 VAL 309 309 309 VAL VAL B . n 
B 1 310 SER 310 310 310 SER SER B . n 
B 1 311 TYR 311 311 311 TYR TYR B . n 
B 1 312 LEU 312 312 312 LEU LEU B . n 
B 1 313 PHE 313 313 313 PHE PHE B . n 
B 1 314 SER 314 314 314 SER SER B . n 
B 1 315 HIS 315 315 315 HIS HIS B . n 
B 1 316 VAL 316 316 316 VAL VAL B . n 
B 1 317 PRO 317 317 317 PRO PRO B . n 
B 1 318 LEU 318 318 ?   ?   ?   B . n 
B 1 319 LEU 319 319 ?   ?   ?   B . n 
B 1 320 GLU 320 320 ?   ?   ?   B . n 
B 1 321 HIS 321 321 ?   ?   ?   B . n 
B 1 322 HIS 322 322 ?   ?   ?   B . n 
B 1 323 HIS 323 323 ?   ?   ?   B . n 
B 1 324 HIS 324 324 ?   ?   ?   B . n 
B 1 325 HIS 325 325 ?   ?   ?   B . n 
B 1 326 HIS 326 326 ?   ?   ?   B . n 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   hexameric 
_pdbx_struct_assembly.oligomeric_count     6 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2,3 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 28360 ? 
1 MORE         -367  ? 
1 'SSA (A^2)'  60540 ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_555 -y,x-y,z  -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 0.8660254038  -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 3_555 -x+y,-x,z -0.5000000000 0.8660254038  0.0000000000 0.0000000000 -0.8660254038 -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2015-02-04 
2 'Structure model' 1 1 2015-03-25 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_software.name 
_software.classification 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
HKL-2000 'data collection' .        ? 1 
MOLREP   phasing           .        ? 2 
REFMAC   refinement        5.5.0109 ? 3 
HKL-2000 'data reduction'  .        ? 4 
HKL-2000 'data scaling'    .        ? 5 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   N 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   THR 
_pdbx_validate_close_contact.auth_seq_id_1    225 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O3 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   SO4 
_pdbx_validate_close_contact.auth_seq_id_2    1002 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.08 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB A SER 58  ? ? CA A SER 58  ? ? C  A SER 58  ? ? 92.59  110.10 -17.51 1.90 N 
2 1 N  A GLY 59  ? ? CA A GLY 59  ? ? C  A GLY 59  ? ? 137.61 113.10 24.51  2.50 N 
3 1 C  A SER 169 ? ? N  A PRO 170 ? ? CA A PRO 170 ? ? 128.82 119.30 9.52   1.50 Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 37  ? ? -98.56  35.87   
2  1 GLN A 38  ? ? 73.28   -6.16   
3  1 CYS A 60  ? ? -80.36  40.74   
4  1 GLN A 97  ? ? -97.80  56.13   
5  1 ASP A 101 ? ? 75.65   41.78   
6  1 ARG A 104 ? ? -92.81  43.37   
7  1 ILE A 107 ? ? -100.01 79.20   
8  1 ASP A 224 ? ? -124.80 -60.40  
9  1 PHE A 266 ? ? -36.10  115.14  
10 1 ASN A 273 ? ? -99.63  45.69   
11 1 SER B 10  ? ? 47.89   -128.11 
12 1 GLN B 38  ? ? 85.15   -3.69   
13 1 THR B 43  ? ? -163.94 112.81  
14 1 ARG B 96  ? ? -60.23  3.03    
15 1 LYS B 102 ? ? 52.53   6.69    
16 1 ARG B 104 ? ? -96.84  48.98   
17 1 ARG B 196 ? ? -43.50  155.62  
18 1 ASP B 213 ? ? 53.92   17.88   
19 1 ASP B 224 ? ? -91.12  -67.67  
20 1 SER B 314 ? ? -145.30 -0.14   
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A SER 10 ? OG ? A SER 10 OG 
2 1 Y 1 A SER 58 ? OG ? A SER 58 OG 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A PRO 2   ? A PRO 2   
3  1 Y 1 A ARG 196 ? A ARG 196 
4  1 Y 1 A LYS 197 ? A LYS 197 
5  1 Y 1 A LYS 198 ? A LYS 198 
6  1 Y 1 A ALA 199 ? A ALA 199 
7  1 Y 1 A ASN 200 ? A ASN 200 
8  1 Y 1 A GLU 201 ? A GLU 201 
9  1 Y 1 A VAL 202 ? A VAL 202 
10 1 Y 1 A SER 314 ? A SER 314 
11 1 Y 1 A HIS 315 ? A HIS 315 
12 1 Y 1 A VAL 316 ? A VAL 316 
13 1 Y 1 A PRO 317 ? A PRO 317 
14 1 Y 1 A LEU 318 ? A LEU 318 
15 1 Y 1 A LEU 319 ? A LEU 319 
16 1 Y 1 A GLU 320 ? A GLU 320 
17 1 Y 1 A HIS 321 ? A HIS 321 
18 1 Y 1 A HIS 322 ? A HIS 322 
19 1 Y 1 A HIS 323 ? A HIS 323 
20 1 Y 1 A HIS 324 ? A HIS 324 
21 1 Y 1 A HIS 325 ? A HIS 325 
22 1 Y 1 A HIS 326 ? A HIS 326 
23 1 Y 1 B MET 1   ? B MET 1   
24 1 Y 1 B PRO 2   ? B PRO 2   
25 1 Y 1 B LYS 198 ? B LYS 198 
26 1 Y 1 B ALA 199 ? B ALA 199 
27 1 Y 1 B ASN 200 ? B ASN 200 
28 1 Y 1 B GLU 201 ? B GLU 201 
29 1 Y 1 B VAL 202 ? B VAL 202 
30 1 Y 1 B LEU 318 ? B LEU 318 
31 1 Y 1 B LEU 319 ? B LEU 319 
32 1 Y 1 B GLU 320 ? B GLU 320 
33 1 Y 1 B HIS 321 ? B HIS 321 
34 1 Y 1 B HIS 322 ? B HIS 322 
35 1 Y 1 B HIS 323 ? B HIS 323 
36 1 Y 1 B HIS 324 ? B HIS 324 
37 1 Y 1 B HIS 325 ? B HIS 325 
38 1 Y 1 B HIS 326 ? B HIS 326 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        'SULFATE ION' 
_pdbx_entity_nonpoly.comp_id     SO4 
# 
loop_
_pdbx_reflns_twin.domain_id 
_pdbx_reflns_twin.crystal_id 
_pdbx_reflns_twin.diffrn_id 
_pdbx_reflns_twin.type 
_pdbx_reflns_twin.operator 
_pdbx_reflns_twin.fraction 
1 1 1 ? 'H, K, L'  0.914 
2 1 1 ? 'K, H, -L' 0.086 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 SO4 1 1001 1001 SO4 SO4 A . 
D 2 SO4 1 1002 1004 SO4 SO4 A . 
E 2 SO4 1 401  1002 SO4 SO4 B . 
F 2 SO4 1 402  1003 SO4 SO4 B . 
G 2 SO4 1 403  1005 SO4 SO4 B . 
# 
