MUTAFY

Mutafy is a webserver to identify experimentally solved mutant and wild-type human protein structures from the Protein Data Bank (PDB). In brief, Mutafy takes a list of HGNC gene symbols as input and will

1. identify all associated protein structures available in the PDB
2. identify mutations and and wild-type structures with respect to the canonical sequence from Uniprot
3. retrieve the AlphaFold predicted structure is an experimentally solved structure of the wild-type could not be found in the PDB
4. use ClinVar to annotate the variants with clinical relevant information about the identified mutant proteins
5. rank the structures by quality and % of solved amino acids
6. make the results available via on line interactive tables and the structures downloadable with a click
7. email summary results to the user

Please visit the tutorial section for detailed instructions about how to use Mutify and a description of the outputs

Info

Data loaded for

Length

Two pieces of information are presented here to help you choose: the first is the length of the protein and the second is the partners if any in the structure.

Binding partners

Proteins can be crystallised with ligands or binding partners and it is often beneficial to choose a specific one.